{"id":26615,"date":"2021-04-15T12:18:00","date_gmt":"2021-04-15T05:18:00","guid":{"rendered":"https:\/\/www.xinwengao.com\/cn\/pr\/2021041512180026615"},"modified":"2021-04-15T21:39:33","modified_gmt":"2021-04-15T13:39:33","slug":"%e5%8b%83%e6%9e%97%e6%a0%bc%e6%ae%b7%e6%a0%bc%e7%bf%b0%e5%92%8cmd%e5%ae%89%e5%be%b7%e6%a3%ae%e6%89%a9%e5%a4%a7%e5%90%88%e4%bd%9c%e4%bb%a5%e5%8a%a0%e9%80%9fkras%e5%92%8ctrailr2%e5%8c%96%e5%90%88","status":"publish","type":"post","link":"https:\/\/www.xinwengao.com\/cn\/pr\/2021041512180026615","title":{"rendered":"\u52c3\u6797\u683c\u6bb7\u683c\u7ff0\u548cMD\u5b89\u5fb7\u68ee\u6269\u5927\u5408\u4f5c\u4ee5\u52a0\u901fKRAS\u548cTRAILR2\u5316\u5408\u7269\u5728\u80ba\u764c\u9886\u57df\u7684\u5f00\u53d1"},"content":{"rendered":"<ul type=\"disc\">\n<li>\u8be5\u5408\u4f5c\u534f\u8bae\u5efa\u7acb\u5728\u901a\u8fc7\u8054\u5408\u865a\u62df\u7814\u53d1\u4e2d\u5fc3\uff08VRDC\uff09\u6210\u529f\u8fdb\u884c\u7684\u80c3\u80a0\u9053\u764c\u75c7\u4e34\u5e8a\u524d\u7814\u7a76\u7684\u57fa\u7840\u4e4b\u4e0a <\/li>\n<li>\u5ef6\u7eed\u7684\u5408\u4f5c\u5c06\u63a2\u7d22\u6765\u81ea\u52c3\u6797\u683c\u6bb7\u683c\u7ff0\u4e0d\u65ad\u589e\u957f\u7684\u764c\u75c7\u6cbb\u7597\u7ec4\u5408\u4e2d\u4ee5KRAS\u548cTRAILR2\u5206\u5b50\u4e3a\u9776\u5411\u7684\u6f5c\u5728\u80ba\u764c\u7597\u6cd5\uff0c\u81f4\u529b\u4e3a\u60a3\u8005\u63d0\u4f9b\u540c\u7c7b\u9996\u521b\u7597\u6cd5<\/li>\n<\/ul>\n<p><p>\u5fb7\u56fd\u6bb7\u683c\u7ff0\u548c\u7f8e\u56fd\u4f11\u65af\u987f2021\u5e744\u670815\u65e5 \/\u7f8e\u901a\u793e\/ &#8212; \u52c3\u6797\u683c\u6bb7\u683c\u7ff0\u516c\u53f8\u548c\u5fb7\u514b\u8428\u65af\u5927\u5b66MD\u5b89\u5fb7\u68ee\u764c\u75c7\u4e2d\u5fc3<span id=\"spanHghlteaa2\">\u8fd1\u65e5<\/span>\u5ba3\u5e03\u5ef6\u957f\u548c\u6269\u5927\u5176\u8054\u5408\u865a\u62df\u7814\u53d1\u4e2d\u5fc3\uff08VRDC\uff09\uff0c\u4ee5\u63a2\u7d22\u52c3\u6797\u683c\u6bb7\u683c\u7ff0\u516c\u53f8\u7684KRAS\uff08Kirsten\u5927\u9f20\u8089\u7624\uff09\u548cTRAILR2\uff08TNF\u76f8\u5173\u7684\u51cb\u4ea1\u8bf1\u5bfc\u56e0\u5b50\u914d\u4f53\u53d7\u4f53<span id=\"spanHghlt4217\">2\uff09<\/span>\u7ec4\u5408\u4e2d\u7684\u65b0\u5206\u5b50\uff0c\u7528\u4e8e\u5f00\u53d1\u9488\u5bf9\u80ba\u764c\u5c24\u5176\u662f\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u7684\u6f5c\u5728\u7597\u6cd5\u3002<\/p>\n<p>\u8fd9\u9879\u5408\u4f5c\u4e8e2019\u5e74\u542f\u52a8\uff0c\u6210\u529f\u5730\u5c06MD\u5b89\u5fb7\u68ee\u7684\u521b\u65b0\u6027\u4e34\u5e8a\u7814\u7a76\u57fa\u7840\u8bbe\u65bd\u548c\u6cbb\u7597\u53d1\u73b0\u90e8\u95e8\u7684\u4ee5\u60a3\u8005\u4e3a\u9a71\u52a8\u7684\u836f\u7269\u5f00\u53d1\u80fd\u529b\u4e0e\u52c3\u6797\u683c\u6bb7\u683c\u7ff0\u7684\u521b\u65b0\u764c\u75c7\u836f\u7269\u7ba1\u7ebf\u548c\u5f00\u53d1\u7a81\u7834\u6027\u7597\u6cd5\u7684\u4e13\u4e1a\u6280\u672f\u76f8\u7ed3\u5408\u3002\u6839\u636e\u65b0\u534f\u8bae\uff0c\u8054\u5408\u7814\u7a76\u5c06\u7ee7\u7eed\u8fdb\u884c\u4e94\u5e74\u3002<\/p>\n<p>\u201c\u4e0eMD\u5b89\u5fb7\u68ee\u7684\u5408\u4f5c\u52a0\u5f3a\u4e86\u6211\u4eec\u4e3a\u6700\u96be\u6cbb\u7597\u7684\u764c\u75c7\u5bfb\u627e\u89e3\u51b3\u65b9\u6848\u7684\u51b3\u5fc3\uff0c\u8fd9\u4e00\u6700\u65b0\u5408\u4f5c\u6807\u5fd7\u7740\u6211\u4eec\u5411\u524d\u8fc8\u51fa\u4e86\u91cd\u8981\u7684\u4e00\u6b65\uff0c\u5c24\u5176\u5bf9\u6211\u4eec\u7684KRAS\u6574\u4f53\u5f00\u53d1\u8ba1\u5212\u800c\u8a00\uff0c\u201d\u52c3\u6797\u683c\u6bb7\u683c\u7ff0\u5168\u7403\u764c\u75c7\u7814\u7a76\u8d1f\u8d23\u4ebaNorbert Kraut\u535a\u58eb\u8bf4\u3002&nbsp;\u201c\u6211\u4eec\u5f88\u9ad8\u5174\u6269\u5c55\u4e0eMD\u5b89\u5fb7\u68ee\u7684\u5408\u4f5c\u3002\u53cc\u65b9\u90fd\u62e5\u6709\u4e3a\u60a3\u8005\u5171\u540c\u505a\u8d21\u732e\u7684\u51b3\u5fc3\u4ee5\u53ca\u5fd7\u540c\u9053\u5408\u7684\u521b\u65b0\u65b9\u6cd5\uff0c\u76f8\u4fe1\u6211\u4eec\u6709\u6f5c\u529b\u5c06\u836f\u7269\u5e26\u7ed9\u90a3\u4e9b\u4e9f\u9700\u521b\u65b0\u7597\u6cd5\u7684\u80ba\u764c\u548c\u80c3\u80a0\u9053\u764c\u75c7\u60a3\u8005\u3002\u201d<\/p>\n<p>\u865a\u62df\u7814\u53d1\u4e2d\u5fc3\u534f\u8bae\u7684\u7075\u6d3b\u6027\u4f7f\u56e2\u961f\u53ef\u4ee5\u6269\u5c55\u9488\u5bf9KRAS\u548cTRAILR2\u7684\u80ba\u764c\u9002\u5e94\u75c7\u8ba1\u5212\uff0c\u5305\u62ec\u52c3\u6797\u683c\u6bb7\u683c\u7ff0\u7684\u540c\u7c7b\u9996\u521bSOS1&nbsp;:: \u6cdbKRAS\u6291\u5236\u5242\uff08BI 1701963\uff09\uff0cKRAS G12C\u6291\u5236\u5242\uff08BI 1823911\uff09\u548cMEK\uff08BI 3011441\uff09\uff0c\u4ee5\u53ca\u5c1a\u672a\u516c\u5f00\u7684\u65b0\u578b\u53cc\u7279\u5f02\u6027TRAILR2\u6fc0\u52a8\u5242\u3002<\/p>\n<p>\u8be5\u9879\u5408\u4f5c\u5df2\u7ecf\u4ea7\u51fa\u4e86\u8bb8\u591a\u5171\u540c\u53d1\u8868\u7684\u6587\u7ae0<sup>[1]<\/sup>\u3001\u5927\u4f1a\u6f14\u8bb2\uff08\u5305\u62ec\u57282021\u5e74AACR\u5e74\u5ea6\u4f1a\u8bae\u4e0a<sup>[2]<\/sup>\uff09\u548c\u4e34\u5e8a\u8bd5\u9a8c\u6d3b\u52a8\u3002\u52c3\u6797\u683c\u6bb7\u683c\u7ff0\u6b63\u5728\u9488\u5bf9KRAS\u7a81\u53d8\u8fdb\u884c\u5168\u9762\u7684\u7814\u7a76\uff0c\u9884\u8ba1\u5c06\u6709\u591a\u4e2a\u8ba1\u5212\u8fdb\u5165\u4e0eMD\u5b89\u5fb7\u68ee\u5408\u4f5c\u7684\u865a\u62df\u7814\u53d1\u4e2d\u5fc3\u3002<\/p>\n<p>\u201c\u6211\u4eec\u5f88\u81ea\u8c6a\uff0c\u5728\u4e00\u4e2a\u975e\u5e38\u6fc0\u52a8\u4eba\u5fc3\u7684\u836f\u7269\u5f00\u53d1\u9886\u57df\u6269\u5927\u4e0e\u52c3\u6797\u683c\u6bb7\u683c\u7ff0\u516c\u53f8\u7684\u5408\u4f5c\u2013\u63a8\u8fdb\u9488\u5bf9KRAS\u548cTRAILR2\u7684\u65b0\u578b\u9776\u5411\u7597\u6cd5\uff0c\u201dMD\u5b89\u5fb7\u68ee\u6cbb\u7597\u53d1\u73b0\u90e8\u95e8\u80bf\u7624\u7814\u7a76\u8d1f\u8d23\u4ebaTimothy Heffernan\u535a\u58eb\u8bf4\u3002&nbsp;\u201c\u6211\u4eec\u7684\u5408\u4f5c\u5efa\u7acb\u5728\u7262\u56fa\u7684\u5de5\u4f5c\u5173\u7cfb\u548c\u4e92\u8865\u7684\u4e13\u4e1a\u77e5\u8bc6\u7684\u57fa\u7840\u4e0a\uff0c\u5c55\u793a\u4e86\u5b66\u672f\u673a\u6784\u548c\u5236\u836f\u516c\u53f8\u5982\u4f55\u80fd\u591f\u6218\u7565\u6027\u5730\u5408\u4f5c\uff0c\u5171\u540c\u4e3a\u764c\u75c7\u60a3\u8005\u63a8\u8fdb\u521b\u65b0\u7597\u6cd5\u7684\u5f00\u53d1\u3002\u201d<\/p>\n<p>MD\u5b89\u5fb7\u68ee\u7684\u6cbb\u7597\u53d1\u73b0\u90e8\u95e8\u7531\u4e00\u652f\u7ecf\u9a8c\u4e30\u5bcc\u7684\u836f\u7269\u5f00\u53d1\u4e13\u5bb6\u56e2\u961f\u4e3b\u5bfc\uff0c\u81f4\u529b\u4e8e\u63a8\u52a8\u4e0b\u4e00\u4ee3\u764c\u75c7\u6cbb\u7597\u7684\u53d1\u5c55\u3002\u7531\u8d6b\u5f17\u5357\uff08Heffernan\uff09\u7275\u5934\u7684\u201c\u4fc3\u8fdb\u80bf\u7624\u5b66\u6cbb\u7597\u548c\u521b\u65b0\u7684\u8f6c\u5316\u7814\u7a76\u201d\uff08TRACTION\uff09\u5e73\u53f0\u8fdb\u884c\u4e86\u524d\u6cbf\u7684\u8f6c\u5316\u7814\u7a76\uff0c\u4ee5\u5c06\u65b0\u7597\u6cd5\u5feb\u901f\u63a8\u5411\u6700\u6709\u53ef\u80fd\u53d7\u76ca\u7684\u60a3\u8005\u3002<\/p>\n<p>KRAS\u662f\u6700\u5e38\u89c1\u7684\u7a81\u53d8\u81f4\u764c\u57fa\u56e0\u3002\u5728\u6240\u6709\u4eba\u7c7b\u8f6c\u79fb\u6027\u764c\u75c7\u4e2d\uff0c\u6709\u4e03\u5206\u4e4b\u4e00\u4e3aKRAS\u7a81\u53d8\uff0c\u5176\u4e2d\u80ba\u817a\u764c\u7684\u7a81\u53d8\u7387\u8d85\u8fc730%\uff0c\u5927\u80a0\u764c\u7684\u7a81\u53d8\u7387\u8d85\u8fc740%\uff0c\u80f0\u817a\u764c\u7684\u7a81\u53d8\u7387\u8d85\u8fc790%\u3002\u800c\u76ee\u524d\uff0c\u5c1a\u65e0\u9488\u5bf9KRAS\u9a71\u52a8\u7684\u764c\u75c7\u7684\u7597\u6cd5\u83b7\u6279\uff0c\u8fdb\u4e00\u6b65\u8bf4\u660e\u7ee7\u7eed\u5728\u8fd9\u4e00\u9886\u57df\u8fdb\u884c\u7814\u7a76\u548c\u5f00\u53d1\u7684\u91cd\u8981\u6027\u3002TRAILR2\u7684\u80bf\u7624\u7ec6\u80de\u9009\u62e9\u6027\u6fc0\u6d3b\u53ef\u4ee5\u89e6\u53d1\u591a\u79cd\u9002\u5e94\u75c7\u4e2d\u7684\u764c\u7ec6\u80de\u6b7b\u4ea1\uff0c\u8fd9\u4e9b\u9002\u5e94\u75c7\u62e5\u6709\u9ad8\u5ea6\u672a\u6ee1\u8db3\u7684\u533b\u7597\u9700\u6c42\uff0c\u5305\u62ec\u80ba\u548c\u80c3\u80a0\u9053\u6076\u6027\u80bf\u7624\u3002<\/p>\n<p><b>\u53c2\u8003\u6587\u732e<\/b><\/p>\n[1]&nbsp;Marco H. Hofmann, <span class=\"xn-person\">Michael Gmachl<\/span>, <span class=\"xn-person\">Juergen Ramharter<\/span>, et al. BI-3406, a Potent and Selective SOS1-KRAS Interaction Inhibitor, Is Effective in KRAS-Driven Cancers through Combined MEK Inhibition. Cancer Discovery 2021;11:1-16.<br \/>[2] Joint presentations at the 2021 American Association for Cancer Research (AACR) Annual Meeting, held virtually <span class=\"xn-chron\">April 10-15, 2021<\/span>:<\/p>\n<ul type=\"disc\">\n<li>Presentation Title: Trial in Process: Phase 1 studies of BI 1701963, a SOS1::KRAS Inhibitor, in combination with MEK inhibitors, irreversible KRASG12C inhibitors or irinotecan.<br \/>Abstract Number: CT210 <\/li>\n<li>Presentation Title: <i>In vitro<\/i>&nbsp;and <i>in vivo<\/i>&nbsp;characterization of BI 1823911 &#8211; a novel KRASG12C selective small molecule inhibitor.<br \/>Abstract Number: 1271 <\/li>\n<li>Presentation Title: BI 905711 selectively induces apoptosis and anti-tumor response in TRAILR2\/CDH17- expressing pancreatic cancer models.<br \/>Abstract Number: 985<\/li>\n<\/ul>\n<p>\u76f8\u5173\u94fe\u63a5 :<\/p>\n<p>http:\/\/www.boehringer-ingelheim.cn<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u8be5\u5408\u4f5c\u534f\u8bae\u5efa\u7acb\u5728\u901a\u8fc7\u8054\u5408\u865a\u62df\u7814\u53d1\u4e2d\u5fc3\uff08VRDC\uff09\u6210\u529f\u8fdb\u884c\u7684\u80c3\u80a0\u9053\u764c\u75c7\u4e34\u5e8a\u524d\u7814\u7a76\u7684\u57fa\u7840\u4e4b\u4e0a \u5ef6\u7eed\u7684\u5408\u4f5c\u5c06\u63a2\u7d22\u6765\u81ea\u52c3\u6797\u683c\u6bb7\u683c\u7ff0\u4e0d\u65ad\u589e\u957f\u7684\u764c\u75c7\u6cbb\u7597\u7ec4\u5408\u4e2d\u4ee5KRAS\u548cTRAILR2\u5206\u5b50\u4e3a\u9776\u5411\u7684\u6f5c\u5728\u80ba\u764c\u7597\u6cd5\uff0c\u81f4\u529b\u4e3a\u60a3\u8005\u63d0\u4f9b\u540c\u7c7b\u9996\u521b\u7597\u6cd5 \u5fb7\u56fd\u6bb7\u683c\u7ff0\u548c\u7f8e\u56fd\u4f11\u65af\u987f2021\u5e744\u670815\u65e5 \/\u7f8e\u901a\u793e\/ &#8212; \u52c3\u6797\u683c\u6bb7\u683c\u7ff0\u516c\u53f8\u548c\u5fb7\u514b\u8428\u65af\u5927\u5b66MD\u5b89\u5fb7\u68ee\u764c\u75c7\u4e2d\u5fc3\u8fd1\u65e5\u5ba3\u5e03\u5ef6\u957f\u548c\u6269\u5927\u5176\u8054\u5408\u865a\u62df\u7814\u53d1\u4e2d\u5fc3\uff08VRDC\uff09\uff0c\u4ee5\u63a2\u7d22\u52c3\u6797\u683c\u6bb7\u683c\u7ff0\u516c\u53f8\u7684KRAS\uff08Kirsten\u5927\u9f20\u8089\u7624\uff09\u548cTRAILR2\uff08TNF\u76f8\u5173\u7684\u51cb\u4ea1\u8bf1\u5bfc\u56e0\u5b50\u914d\u4f53\u53d7\u4f532\uff09\u7ec4\u5408\u4e2d\u7684\u65b0\u5206\u5b50\uff0c\u7528\u4e8e\u5f00\u53d1\u9488\u5bf9\u80ba\u764c\u5c24\u5176\u662f\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u7684\u6f5c\u5728\u7597\u6cd5\u3002 \u8fd9\u9879\u5408\u4f5c\u4e8e2019\u5e74\u542f\u52a8\uff0c\u6210\u529f\u5730\u5c06MD\u5b89\u5fb7\u68ee\u7684\u521b\u65b0\u6027\u4e34\u5e8a\u7814\u7a76\u57fa\u7840\u8bbe\u65bd\u548c\u6cbb\u7597\u53d1\u73b0\u90e8\u95e8\u7684\u4ee5\u60a3\u8005\u4e3a\u9a71\u52a8\u7684\u836f\u7269\u5f00\u53d1\u80fd\u529b\u4e0e\u52c3\u6797\u683c\u6bb7\u683c\u7ff0\u7684\u521b\u65b0\u764c\u75c7\u836f\u7269\u7ba1\u7ebf\u548c\u5f00\u53d1\u7a81\u7834\u6027\u7597\u6cd5\u7684\u4e13\u4e1a\u6280\u672f\u76f8\u7ed3\u5408\u3002\u6839\u636e\u65b0\u534f\u8bae\uff0c\u8054\u5408\u7814\u7a76\u5c06\u7ee7\u7eed\u8fdb\u884c\u4e94\u5e74\u3002 \u201c\u4e0eMD\u5b89\u5fb7\u68ee\u7684\u5408\u4f5c\u52a0\u5f3a\u4e86\u6211\u4eec\u4e3a\u6700\u96be\u6cbb\u7597\u7684\u764c\u75c7\u5bfb\u627e\u89e3\u51b3\u65b9\u6848\u7684\u51b3\u5fc3\uff0c\u8fd9\u4e00\u6700\u65b0\u5408\u4f5c\u6807\u5fd7\u7740\u6211\u4eec\u5411\u524d\u8fc8\u51fa\u4e86\u91cd\u8981\u7684\u4e00\u6b65\uff0c\u5c24\u5176\u5bf9\u6211\u4eec\u7684KRAS\u6574\u4f53\u5f00\u53d1\u8ba1\u5212\u800c\u8a00\uff0c\u201d\u52c3\u6797\u683c\u6bb7\u683c\u7ff0\u5168\u7403\u764c\u75c7\u7814\u7a76\u8d1f\u8d23\u4ebaNorbert Kraut\u535a\u58eb\u8bf4\u3002&nbsp;\u201c\u6211\u4eec\u5f88\u9ad8\u5174\u6269\u5c55\u4e0eMD\u5b89\u5fb7\u68ee\u7684\u5408\u4f5c\u3002\u53cc\u65b9\u90fd\u62e5\u6709\u4e3a\u60a3\u8005\u5171\u540c\u505a\u8d21\u732e\u7684\u51b3\u5fc3\u4ee5\u53ca\u5fd7\u540c\u9053\u5408\u7684\u521b\u65b0\u65b9\u6cd5\uff0c\u76f8\u4fe1\u6211\u4eec\u6709\u6f5c\u529b\u5c06\u836f\u7269\u5e26\u7ed9\u90a3\u4e9b\u4e9f\u9700\u521b\u65b0\u7597\u6cd5\u7684\u80ba\u764c\u548c\u80c3\u80a0\u9053\u764c\u75c7\u60a3\u8005\u3002\u201d \u865a\u62df\u7814\u53d1\u4e2d\u5fc3\u534f\u8bae\u7684\u7075\u6d3b\u6027\u4f7f\u56e2\u961f\u53ef\u4ee5\u6269\u5c55\u9488\u5bf9KRAS\u548cTRAILR2\u7684\u80ba\u764c\u9002\u5e94\u75c7\u8ba1\u5212\uff0c\u5305\u62ec\u52c3\u6797\u683c\u6bb7\u683c\u7ff0\u7684\u540c\u7c7b\u9996\u521bSOS1&nbsp;:: \u6cdbKRAS\u6291\u5236\u5242\uff08BI 1701963\uff09\uff0cKRAS G12C\u6291\u5236\u5242\uff08BI 1823911\uff09\u548cMEK\uff08BI 3011441\uff09\uff0c\u4ee5\u53ca\u5c1a\u672a\u516c\u5f00\u7684\u65b0\u578b\u53cc\u7279\u5f02\u6027TRAILR2\u6fc0\u52a8\u5242\u3002 \u8be5\u9879\u5408\u4f5c\u5df2\u7ecf\u4ea7\u51fa\u4e86\u8bb8\u591a\u5171\u540c\u53d1\u8868\u7684\u6587\u7ae0[1]\u3001\u5927\u4f1a\u6f14\u8bb2\uff08\u5305\u62ec\u57282021\u5e74AACR\u5e74\u5ea6\u4f1a\u8bae\u4e0a[2]\uff09\u548c\u4e34\u5e8a\u8bd5\u9a8c\u6d3b\u52a8\u3002\u52c3\u6797\u683c\u6bb7\u683c\u7ff0\u6b63\u5728\u9488\u5bf9KRAS\u7a81\u53d8\u8fdb\u884c\u5168\u9762\u7684\u7814\u7a76\uff0c\u9884\u8ba1\u5c06\u6709\u591a\u4e2a\u8ba1\u5212\u8fdb\u5165\u4e0eMD\u5b89\u5fb7\u68ee\u5408\u4f5c\u7684\u865a\u62df\u7814\u53d1\u4e2d\u5fc3\u3002 \u201c\u6211\u4eec\u5f88\u81ea\u8c6a\uff0c\u5728\u4e00\u4e2a\u975e\u5e38\u6fc0\u52a8\u4eba\u5fc3\u7684\u836f\u7269\u5f00\u53d1\u9886\u57df\u6269\u5927\u4e0e\u52c3\u6797\u683c\u6bb7\u683c\u7ff0\u516c\u53f8\u7684\u5408\u4f5c\u2013\u63a8\u8fdb\u9488\u5bf9KRAS\u548cTRAILR2\u7684\u65b0\u578b\u9776\u5411\u7597\u6cd5\uff0c\u201dMD\u5b89\u5fb7\u68ee\u6cbb\u7597\u53d1\u73b0\u90e8\u95e8\u80bf\u7624\u7814\u7a76\u8d1f\u8d23\u4ebaTimothy Heffernan\u535a\u58eb\u8bf4\u3002&nbsp;\u201c\u6211\u4eec\u7684\u5408\u4f5c\u5efa\u7acb\u5728\u7262\u56fa\u7684\u5de5\u4f5c\u5173\u7cfb\u548c\u4e92\u8865\u7684\u4e13\u4e1a\u77e5\u8bc6\u7684\u57fa\u7840\u4e0a\uff0c\u5c55\u793a\u4e86\u5b66\u672f\u673a\u6784\u548c\u5236\u836f\u516c\u53f8\u5982\u4f55\u80fd\u591f\u6218\u7565\u6027\u5730\u5408\u4f5c\uff0c\u5171\u540c\u4e3a\u764c\u75c7\u60a3\u8005\u63a8\u8fdb\u521b\u65b0\u7597\u6cd5\u7684\u5f00\u53d1\u3002\u201d MD\u5b89\u5fb7\u68ee\u7684\u6cbb\u7597\u53d1\u73b0\u90e8\u95e8\u7531\u4e00\u652f\u7ecf\u9a8c\u4e30\u5bcc\u7684\u836f\u7269\u5f00\u53d1\u4e13\u5bb6\u56e2\u961f\u4e3b\u5bfc\uff0c\u81f4\u529b\u4e8e\u63a8\u52a8\u4e0b\u4e00\u4ee3\u764c\u75c7\u6cbb\u7597\u7684\u53d1\u5c55\u3002\u7531\u8d6b\u5f17\u5357\uff08Heffernan\uff09\u7275\u5934\u7684\u201c\u4fc3\u8fdb\u80bf\u7624\u5b66\u6cbb\u7597\u548c\u521b\u65b0\u7684\u8f6c\u5316\u7814\u7a76\u201d\uff08TRACTION\uff09\u5e73\u53f0\u8fdb\u884c\u4e86\u524d\u6cbf\u7684\u8f6c\u5316\u7814\u7a76\uff0c\u4ee5\u5c06\u65b0\u7597\u6cd5\u5feb\u901f\u63a8\u5411\u6700\u6709\u53ef\u80fd\u53d7\u76ca\u7684\u60a3\u8005\u3002 KRAS\u662f\u6700\u5e38\u89c1\u7684\u7a81\u53d8\u81f4\u764c\u57fa\u56e0\u3002\u5728\u6240\u6709\u4eba\u7c7b\u8f6c\u79fb\u6027\u764c\u75c7\u4e2d\uff0c\u6709\u4e03\u5206\u4e4b\u4e00\u4e3aKRAS\u7a81\u53d8\uff0c\u5176\u4e2d\u80ba\u817a\u764c\u7684\u7a81\u53d8\u7387\u8d85\u8fc730%\uff0c\u5927\u80a0\u764c\u7684\u7a81\u53d8\u7387\u8d85\u8fc740%\uff0c\u80f0\u817a\u764c\u7684\u7a81\u53d8\u7387\u8d85\u8fc790%\u3002\u800c\u76ee\u524d\uff0c\u5c1a\u65e0\u9488\u5bf9KRAS\u9a71\u52a8\u7684\u764c\u75c7\u7684\u7597\u6cd5\u83b7\u6279\uff0c\u8fdb\u4e00\u6b65\u8bf4\u660e\u7ee7\u7eed\u5728\u8fd9\u4e00\u9886\u57df\u8fdb\u884c\u7814\u7a76\u548c\u5f00\u53d1\u7684\u91cd\u8981\u6027\u3002TRAILR2\u7684\u80bf\u7624\u7ec6\u80de\u9009\u62e9\u6027\u6fc0\u6d3b\u53ef\u4ee5\u89e6\u53d1\u591a\u79cd\u9002\u5e94\u75c7\u4e2d\u7684\u764c\u7ec6\u80de\u6b7b\u4ea1\uff0c\u8fd9\u4e9b\u9002\u5e94\u75c7\u62e5\u6709\u9ad8\u5ea6\u672a\u6ee1\u8db3\u7684\u533b\u7597\u9700\u6c42\uff0c\u5305\u62ec\u80ba\u548c\u80c3\u80a0\u9053\u6076\u6027\u80bf\u7624\u3002 \u53c2\u8003\u6587\u732e [1]&nbsp;Marco H. Hofmann, Michael Gmachl, Juergen Ramharter, et al. BI-3406, a Potent and Selective SOS1-KRAS Interaction Inhibitor, Is Effective in KRAS-Driven Cancers through Combined MEK Inhibition. Cancer Discovery 2021;11:1-16.[2] Joint presentations at the 2021&hellip; <a class=\"read-more\" href=\"https:\/\/www.xinwengao.com\/cn\/pr\/2021041512180026615\">Read More<\/a><\/p>\n","protected":false},"author":556,"featured_media":8278,"comment_status":"close","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1965],"tags":[],"class_list":["post-26615","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-partnerships"],"amp_enabled":true,"_links":{"self":[{"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/posts\/26615","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/users\/556"}],"replies":[{"embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/comments?post=26615"}],"version-history":[{"count":1,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/posts\/26615\/revisions"}],"predecessor-version":[{"id":26616,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/posts\/26615\/revisions\/26616"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/media\/8278"}],"wp:attachment":[{"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/media?parent=26615"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/categories?post=26615"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/tags?post=26615"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}