{"id":26603,"date":"2021-04-15T08:00:00","date_gmt":"2021-04-15T01:00:00","guid":{"rendered":"https:\/\/www.xinwengao.com\/cn\/pr\/2021041508000026603"},"modified":"2021-04-15T21:39:11","modified_gmt":"2021-04-15T13:39:11","slug":"%e9%98%bf%e8%af%ba%e5%8c%bb%e8%8d%af%e5%ae%a3%e5%b8%83buparlisib%ef%bc%88an2025%ef%bc%89%e6%b2%bb%e7%96%97%e5%a4%8d%e5%8f%91%e6%80%a7%e6%88%96%e8%bd%ac%e7%a7%bb%e6%80%a7%e5%a4%b4%e9%a2%88%e7%99%8c","status":"publish","type":"post","link":"https:\/\/www.xinwengao.com\/cn\/pr\/2021041508000026603","title":{"rendered":"\u963f\u8bfa\u533b\u836f\u5ba3\u5e03Buparlisib\uff08AN2025\uff09\u6cbb\u7597\u590d\u53d1\u6027\u6216\u8f6c\u79fb\u6027\u5934\u9888\u764c\u7684\u5168\u7403III\u671f\u4e34\u5e8a\u5b8c\u6210\u9996\u4f8b\u60a3\u8005\u7ed9\u836f"},"content":{"rendered":"<p><p><span class=\"xn-subheadline\">\u5f00\u542f\u4e16\u754c\u8303\u56f4\u5185PI3K\u836f\u7269\u5728\u5934\u9888\u764c\u6cbb\u7597\u9886\u57df\u7684\u9996\u4e2a\u5168\u7403\u591a\u4e2d\u5fc3\u5927\u578bIII\u671f\u4e34\u5e8a\u8bd5\u9a8c<\/span><\/p>\n<p>\u4e2d\u56fd\u676d\u5dde2021\u5e744\u670815\u65e5 \/\u7f8e\u901a\u793e\/ &#8212; \u963f\u8bfa\u533b\u836f\uff0c\u4e00\u5bb6\u4e13\u6ce8\u4e8e\u80bf\u7624\u6cbb\u7597\u9886\u57df\u7684\u521b\u65b0\u578b\u5168\u7403\u751f\u7269\u5236\u836f\u516c\u53f8\uff0c\u4eca\u65e5\u5ba3\u5e03\u5176\u53e3\u670dPI3K\u6291\u5236\u5242Buparlisib\uff08AN2025\uff09\u8054\u5408\u7d2b\u6749\u9187\u7528\u4e8e\u6cbb\u7597\u590d\u53d1\u6027\u6216\u8f6c\u79fb\u6027\u5934\u9888\u90e8\u9cde\u72b6\u7ec6\u80de\u764c\u7684\u5168\u7403\u591a\u4e2d\u5fc3III\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff08\u7814\u7a76\u540d\u79f0BURAN\uff09\u5df2\u4e8e\u4e2d\u56fd\u4e0a\u6d77\u4e1c\u65b9\u533b\u9662\u6210\u529f\u5b8c\u6210\u9996\u4f8b\u60a3\u8005\u7ed9\u836f\uff0c\u5f00\u542f\u4e86\u4e16\u754c\u8303\u56f4\u5185PI3K\u836f\u7269\u5728\u5934\u9888\u764c\u6cbb\u7597\u9886\u57df\u7684\u9996\u4e2a\u5168\u7403\u591a\u4e2d\u5fc3\u5927\u578bIII\u671f\u4e34\u5e8a\u8bd5\u9a8c\u3002<\/p>\n<p>\u8be5\u7814\u7a76\u662f\u4e00\u9879\u5728\u5168\u7403\u5f00\u5c55\u7684\u8bc4\u4f30Buparlisib\u8054\u5408\u7d2b\u6749\u9187\u6216\u7d2b\u6749\u9187\u5355\u72ec\u6cbb\u7597\u590d\u53d1\u6027\u6216\u8f6c\u79fb\u6027\u5934\u9888\u90e8\u9cde\u72b6\u7ec6\u80de\u764c\u7597\u6548\u548c\u5b89\u5168\u6027\u7684\u968f\u673a\u3001\u5f00\u653e\u3001\u591a\u4e2d\u5fc3\u7684III\u671f\u4e34\u5e8a\u7814\u7a76\u3002\u4e3b\u8981\u7814\u7a76\u7ec8\u70b9\u662f\u60a3\u8005\u603b\u751f\u5b58\u671f\u3002\u672c\u7814\u7a76\u8ba1\u5212\u5728\u5317\u7f8e\u3001\u6b27\u6d32\u53ca\u4e9a\u592a\u768415\u4e2a\u4e3b\u8981\u56fd\u5bb6\u548c\u5730\u533a\u4e2d\u7684150\u591a\u5bb6\u7814\u7a76\u4e2d\u5fc3\u62db\u52df\u8fd1500\u4f4d\u5934\u9888\u90e8\u9cde\u72b6\u7ec6\u80de\u764c\u60a3\u8005\uff0c\u5165\u7ec4\u6807\u51c6\u5305\u62ec\u66fe\u63a5\u53d7\u8fc7PD-1\/PD-L1\u5355\u836f\u6cbb\u7597\uff0cPD-1\/PD-L1\u8054\u7528\u94c2\u7c7b\u5316\u7597\u6216\u6309\u5e8f\u5217\u63a5\u53d7PD-1\/PD-L1\u6cbb\u7597\u548c\u542b\u94c2\u7c7b\u5316\u7597\uff08\u65e0\u8bba\u5148\u540e\u987a\u5e8f\uff09\u540e\u51fa\u73b0\u75be\u75c5\u8fdb\u5c55\u7684\u60a3\u8005\u3002<\/p>\n<p>\u5934\u9888\u90e8\u9cde\u72b6\u7ec6\u80de\u764c\u7684\u5168\u7403\u53d1\u75c5\u7387\u5c45\u6076\u6027\u80bf\u7624\u7b2c\u516b\u4f4d\uff0c\u6b7b\u4ea1\u7387\u5c45\u7b2c\u5341\u4e8c\u4f4d\uff0c\u6bcf\u5e74\u65b0\u53d1\u7ea684\u4e07\u4f8b<sup><span id=\"spanHghlt63b7\">[1]<\/span><\/sup>\u3002\u8fd1\u5e74\u6765\uff0c\u5c3d\u7ba1\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\u7684\u51fa\u73b0\u7ed9\u5934\u9888\u90e8\u9cde\u72b6\u7ec6\u80de\u764c\u60a3\u8005\u5e26\u6765\u4e86\u663e\u8457\u7684\u4e34\u5e8a\u83b7\u76ca\uff0c\u4f46\u5176\u5355\u836f\u6216\u8054\u5408\u5316\u7597\u6cbb\u7597\u590d\u53d1\u6027\u6216\u8f6c\u79fb\u6027\u5934\u9888\u90e8\u9cde\u72b6\u7ec6\u80de\u764c\u603b\u4f53\u53cd\u5e94\u7387\u4e0d\u9ad8<sup><span id=\"spanHghlt7c60\">[2]<\/span><\/sup>\u3002\u5bf9\u4e8e\u4f7f\u7528\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\u540e\u6ca1\u6709\u54cd\u5e94\u6216\u51fa\u73b0\u75be\u75c5\u8fdb\u5c55\u7684\u60a3\u8005\uff0c\u76ee\u524d\u5c1a\u65e0\u5176\u4ed6\u6cbb\u7597\u9009\u62e9\u4e14\u8fd9\u7c7b\u60a3\u8005\u6570\u91cf\u6b63\u5728\u9010\u5e74\u589e\u52a0\u3002\u56e0\u6b64\uff0c\u4e34\u5e8a\u4e9f\u9700\u63a2\u7d22\u66f4\u591a\u6709\u6548\u7684\u6cbb\u7597\u65b9\u5f0f\uff0c\u63d0\u9ad8\u60a3\u8005\u6574\u4f53\u751f\u5b58\u83b7\u76ca\u3002<\/p>\n<p><b>\u5168\u7403\u5934\u9888\u764c\u7814\u7a76\u9886\u57df\u77e5\u540d\u4e13\u5bb6\u3001\u8be5\u7814\u7a76\u7275\u5934\u4eba<\/b><b>Denis Souli&egrave;res<\/b><b>\u6559\u6388\u8868\u793a\uff1a<\/b>\u201c\u6b64\u524d\u5df2\u5b8c\u6210\u7684\u5168\u7403II\u671f\u4e34\u5e8a\u8bd5\u9a8c\u7ed3\u679c\u663e\u793aBuparlisib\uff08AN2025\uff09\u5177\u6709\u826f\u597d\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\uff0c\u6b64\u6b21\u5168\u7403III\u671f\u4e34\u5e8a\u8bd5\u9a8c\u7684\u76ee\u6807\u662f\u4e3a\u7ecf\u514d\u75ab\u6cbb\u7597\u6216\u514d\u75ab\u6cbb\u7597\u4e0e\u542b\u94c2\u7c7b\u5316\u7597\u8054\u5408\u4f7f\u7528\u540e\u51fa\u73b0\u8fdb\u5c55\u7684\u60a3\u8005\uff0c\u4e3a\u5176\u63d0\u4f9b\u6bd4\u7d2b\u6749\u9187\u66f4\u6709\u6548\u7684\u6cbb\u7597\u65b9\u5f0f\u3002\u201d<\/p>\n<p>\u201c\u5934\u9888\u90e8\u9cde\u72b6\u7ec6\u80de\u764c\u8fd1\u51e0\u5e74\u53d6\u5f97\u4e86\u5f88\u5927\u7684\u7a81\u7834\uff0c\u4f46\u5bf9\u4e8e\u590d\u53d1\u6216\u8f6c\u79fb\u6027\u7684\u60a3\u8005\u6765\u8bf4\u4ecd\u5b58\u5728\u672a\u88ab\u6ee1\u8db3\u7684\u9700\u6c42\u3002\u8be5\u7814\u7a76\u6709\u671b\u6539\u53d8\u5934\u9888\u90e8\u9cde\u72b6\u7ec6\u80de\u764c\u4e8c\u7ebf\u6cbb\u7597\u683c\u5c40\uff0c\u4e3a\u4e2d\u56fd\u53ca\u5168\u7403\u60a3\u8005\u63d0\u4f9b\u5168\u65b0\u7684\u6cbb\u7597\u9009\u62e9\u3002\u201d<b>\u540c\u6d4e\u5927\u5b66\u9644\u5c5e\u4e1c\u65b9\u533b\u9662\u4e00\u671f\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u5fc3\u4e3b\u4efb\uff0c\u4e2d\u56fd\u4e34\u5e8a\u80bf\u7624\u5b66\u4f1a\u5934\u9888\u80bf\u7624\u4e13\u59d4\u4f1a\u4e3b\u59d4<\/b><b>\uff0c\u90ed\u6654\u6559\u6388\u6307\u51fa<\/b>\uff0c\u201c\u4f5c\u4e3a\u533b\u751f\u5f88\u6b23\u6170\u5730\u770b\u5230\u8d8a\u6765\u8d8a\u591a\u7684\u7814\u7a76\u5728\u4e2d\u56fd\u5f00\u5c55\u5e76\u53c2\u4e0e\u5176\u4e2d\uff0c\u5728\u4e2d\u56fd\u5f00\u5c55\u8bd5\u9a8c\u80fd\u7cbe\u51c6\u7684\u53cd\u6620\u4e2d\u56fd\u4eba\u7fa4\u72b6\u6001\uff0c\u4e3a\u4e34\u5e8a\u7814\u7a76\u79ef\u7d2f\u66f4\u591a\u6570\u636e\u4e0e\u7ecf\u9a8c\uff0c\u63a8\u52a8\u4e2d\u56fd\u5934\u9888\u764c\u8bca\u7597\u8fdb\u5c55\u3002\u201d<\/p>\n<p><b>\u963f\u8bfa\u533b\u836f\u9996\u5e2d\u533b\u5b66\u5b98<\/b><b><span class=\"xn-person\">Lars Birgerson<\/span><\/b><b>\u535a\u58eb\u8868\u793a\uff1a<\/b>\u201c\u4e0e\u4e16\u754c\u9876\u5c16<b>\u7814\u7a76\u4eba\u5458<\/b>\u5408\u4f5c\u5f00\u5c55\u4e34\u5e8a\u8bd5\u9a8c\u662f\u963f\u8bfa\u533b\u836f\u5168\u7403\u5316\u7684\u5f00\u53d1\u7b56\u7565\u4e2d\u975e\u5e38\u91cd\u8981\u7684\u90e8\u5206\u3002\u6211\u4eec\u5e0c\u671b\u963f\u8bfa\u533b\u836f\u7684\u4ea7\u54c1\u80fd\u591f\u5728\u8fd9\u6837\u7684\u5408\u4f5c\u4e0b\u9ad8\u6548\u5730\u8fdb\u5165\u5e02\u573a\uff0c\u4ee5\u60e0\u53ca\u66f4\u591a\u7684\u60a3\u8005\u53ca\u5bb6\u5ead\u3002\u6839\u636e\u6b64\u524d\u5df2\u5b8c\u6210\u7684\u5168\u7403II\u671f\u4e34\u5e8a\u8bd5\u9a8c\u7ed3\u679c\u663e\u793a\u4f7f\u7528Buparlisib\uff08AN2025\uff09\u540e\u60a3\u8005\u7684\u4e2d\u4f4d\u751f\u5b58\u671f\u9ad8\u8fbe10.4\u4e2a\u6708\uff0c\u83b7\u5f97\u4e86\u7f8e\u56fdFDA\u6388\u4e88\u7684\u5feb\u901f\u5ba1\u6279\u901a\u9053\u8d44\u683c\uff0c\u8be5\u836f\u7269\u6709\u671b\u6210\u4e3a\u5934\u9888\u764c\u6cbb\u7597\u9886\u57df\u9996\u4e2a\u4e0a\u5e02\u7684PI3K\u6291\u5236\u5242\uff0c\u4e3a\u5934\u9888\u764c\u6cbb\u7597\u5e26\u6765\u65b0\u7684\u601d\u8def\u3002\u201d<\/p>\n<p><b>\u5173\u4e8e\u5934\u9888\u90e8\u9cde\u72b6\u7ec6\u80de\u764c<br \/><\/b>\u5934\u9888\u90e8\u9cde\u72b6\u7ec6\u80de\u764c\u7684\u5168\u7403\u53d1\u75c5\u7387\u5c45\u6076\u6027\u80bf\u7624\u7b2c\u516b\u4f4d\uff0c\u7ea6\u5360\u6240\u6709\u5934\u9888\u764c\u768490%\u3002&nbsp;2020\u5e74\uff0c\u5934\u9888\u90e8\u9cde\u72b6\u7ec6\u80de\u764c\u7684\u5168\u7403\u53d1\u75c5\u4eba\u6570\u7ea684\u4e07\uff0c\u9884\u8ba1\u52302030\u5e74\u5c06\u4e0a\u5347\u81f3\u7ea6100\u4e07\u3002\u6d41\u884c\u75c5\u5b66\u6570\u636e\u663e\u793a\uff0c50%-60%\u7684\u5934\u9888\u90e8\u9cde\u764c\u60a3\u8005\u5728\u786e\u8bca\u65f6\u5df2\u53d1\u5c55\u4e3a\u5c40\u90e8\u665a\u671f\uff0c\u540c\u65f650%-60%\u7684\u60a3\u8005\u5728\u4e24\u5e74\u5185\u4f1a\u51fa\u73b0\u590d\u53d1\u3002\u590d\u53d1\u6216\u8f6c\u79fb\u6027\u5934\u9888\u90e8\u9cde\u764c\u901a\u5e38\u9884\u540e\u5dee\u3001\u6b7b\u4ea1\u7387\u9ad8\u3002\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\u7684\u51fa\u73b0\u7ed9\u60a3\u8005\u5e26\u6765\u4e86\u751f\u5b58\u83b7\u76ca\uff0c\u4f46\u4e5f\u6709\u90e8\u5206\u60a3\u8005\u7ecfPD-1\/PD-L1\u6216PD-1\/PD-L1\u8054\u7528\u5316\u7597\u540e\u6ca1\u6709\u54cd\u5e94\uff0c\u4e14\u8fd9\u4e00\u90e8\u5206\u7684\u6bd4\u4f8b\u6b63\u9010\u6e10\u4e0a\u5347\u3002\u76ee\u524d\u5168\u7403\u5c1a\u65e0\u80fd\u6ee1\u8db3\u8fd9\u7c7b\u60a3\u8005\u9700\u6c42\u7684\u5019\u9009\u836f\u7269\u8fdb\u5165\u6ce8\u518c\u6027\u4e34\u5e8a\u9636\u6bb5\uff0cAN2025\u6709\u671b\u6210\u4e3a\u5168\u7403\u7b2c\u4e00\u4e2a\u4e0a\u5e02\u7684\u76f8\u5173\u836f\u7269\u3002<\/p>\n<p><b>\u5173\u4e8e<\/b><b>BURAN<\/b><b>\u7814\u7a76<\/b> <br \/>BURAN\u7814\u7a76\u662f\u4e00\u9879\u968f\u673a\u3001\u5f00\u653e\u3001\u591a\u4e2d\u5fc3\u7684III\u671f\u7814\u7a76\uff0c\u65e8\u5728\u8bc4\u4f30Buparlisib\uff08AN2025\uff09\uff08\u4e00\u65e5\u4e00\u6b21\uff09\u8054\u5408\u7d2b\u6749\u9187\uff08\u4e00\u5468\u4e00\u6b21\uff09\u4e0e\u7d2b\u6749\u9187\u5355\u72ec\u6cbb\u7597\uff08\u4e00\u5468\u4e00\u6b21\uff09\u590d\u53d1\u6027\u6216\u8f6c\u79fb\u6027\u5934\u9888\u90e8\u9cde\u72b6\u7ec6\u80de\u764c\uff08HNSCC\uff09\u7684\u7597\u6548\u548c\u5b89\u5168\u6027\u3002\u5165\u7ec4\u60a3\u8005\u6807\u51c6\u5305\u62ec\u66fe\u63a5\u53d7\u8fc7PD-1\/PD-L1\u5355\u836f\u6cbb\u7597\uff0cPD-1\/PD-L1\u8054\u7528\u94c2\u7c7b\u5316\u7597\u6216\u6309\u5e8f\u5217\u63a5\u53d7PD-1\/PD-L1\u6cbb\u7597\u548c\u542b\u94c2\u7c7b\u5316\u7597\uff08\u65e0\u8bba\u5148\u540e\u987a\u5e8f\uff09\u540e\u51fa\u73b0\u75be\u75c5\u8fdb\u5c55\u7684\u60a3\u8005\u3002<\/p>\n<p><b>\u5173\u4e8e<\/b><b>Buparlisib (AN2025)<br \/><\/b>Buparlisib (AN2025)\u662f\u4e00\u79cd\u53e3\u670d\u7684\u6cdbPI3K\u6291\u5236\u5242\uff0c\u9488\u5bf9\u6240\u6709\u7684I\u7c7bPI3K\u4e9a\u578b\uff0c\u5728\u8840\u6db2\u6076\u6027\u80bf\u7624\u548c\u5b9e\u4f53\u7624\u4e2d\u5747\u8868\u73b0\u51fa\u6297\u80bf\u7624\u6d3b\u6027\u3002\u5728\u5176\u6cbb\u7597\u5934\u9888\u90e8\u9cde\u72b6\u7ec6\u80de\u764c\uff08HNSCC\uff09\u7684\u5168\u7403II\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff08BERIL-1\uff09\u4e2d\uff0c\u60a3\u8005\u7684\u4e2d\u4f4d\u751f\u5b58\u671f\u9ad8\u8fbe10.4\u4e2a\u6708\uff0c\u83b7\u7f8e\u56fdFDA\u6388\u4e88\u7684\u5feb\u901f\u5ba1\u6279\u901a\u9053\u8d44\u683c\u5e76\u83b7\u6279\u5f00\u5c55III\u671f\u4e34\u5e8a\u8bd5\u9a8c\u3002\u76ee\u524d\uff0cBuparlisib\u9488\u5bf9HNSCC\u7684\u5168\u7403\u591a\u4e2d\u5fc3III\u671f\u4e34\u5e8a\u8bd5\u9a8c\u5df2\u7ecf\u542f\u52a8\u3002<\/p>\n<p><b>\u5173\u4e8e\u963f\u8bfa\u533b\u836f<br \/><\/b>\u963f\u8bfa\u533b\u836f\u662f\u4e00\u5bb6\u4e34\u5e8a\u9636\u6bb5\u7684\u4e13\u6ce8\u4e8e\u521b\u65b0\u578b\u80bf\u7624\u836f\u7269\u5f00\u53d1\u7684\u5168\u7403\u6027\u751f\u7269\u5236\u836f\u516c\u53f8\uff0c\u5728\u4e2d\u7f8e\u4e24\u5730\u5747\u8bbe\u6709\u7814\u53d1\u53ca\u4e34\u5e8a\u8fd0\u8425\u4e2d\u5fc3\u3002\u963f\u8bfa\u533b\u836f\u901a\u8fc7\u201c\u8054\u5408\u521b\u65b0\u201d\u548c\u201c\u81ea\u4e3b\u7814\u53d1\u201d\u7684\u6a21\u5f0f\u6784\u5efa\u8d77\u4e00\u6761\u5168\u7403\u5316\u7684\u4ea7\u54c1\u7ba1\u7ebf\uff0c\u76ee\u524d\u6db5\u76d610\u4f59\u79cd\u6297\u80bf\u7624\u5019\u9009\u836f\u7269\u3002\u5176\u4e2d\u67093\u6b3e\u836f\u7269\u73b0\u5904\u4e8e\u4e34\u5e8a\u9636\u6bb5\uff0c\u5206\u522b\u662f\u5df2\u83b7\u5f97&nbsp;FDA&nbsp;\u5feb\u901f\u901a\u9053\u8d44\u683c\u7684AN2025\uff08Buparlisib\uff09\u9879\u76ee\uff0c\u6b63\u5728\u5f00\u5c55\u5168\u7403\u591a\u4e2d\u5fc33\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff1b\u540c\u6837\u83b7\u5f97&nbsp;FDA&nbsp;\u5feb\u901f\u901a\u9053\u8d44\u683c\u7684\u53ef\u901a\u8fc7\u9759\u8109\u6ce8\u5c04\u7ed9\u836f\u7684\u6eb6\u7624\u75c5\u6bd2&nbsp;AN1004\uff08Pelareorep\uff09\u9879\u76ee\uff0c\u5df2\u5b8c\u62102\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff1b\u9488\u5bf9\u591a\u79cd\u5b9e\u4f53\u7624\u73b0\u5904\u4e8e\u65e9\u671f\u4e34\u5e8a\u5f00\u53d1\u4e2d\u7684\u53e3\u670dEP4\u62ee\u6297\u5242\uff08AN0025\uff09\u9879\u76ee\uff0c\u76ee\u524d\u6b63\u5728\u5c1d\u8bd5\u4e0e\u5176\u4ed6\u6cbb\u7597\u65b9\u6848\uff08\u5305\u62ec\u5316\u653e\u7597\u548cPD-1 \/PD-L1\u6291\u5236\u5242\u7597\u6cd5\uff09\u8054\u5408\u4f7f\u7528\u3002<\/p>\n<p>\u963f\u8bfa\u533b\u836f\u5df2\u7ec4\u5efa\u4e86\u4e00\u652f\u5177\u6709\u7ade\u4e89\u529b\u7684\u7ba1\u7406\u56e2\u961f\uff0c\u5e76\u642d\u5efa\u4e86\u72ec\u7279\u7684\u836f\u7269\u5f00\u53d1\u6280\u672f\u5e73\u53f0\uff0c\u540c\u65f6\u4e0e\u5168\u7403\u591a\u5bb6\u9876\u5c16\u5236\u836f\u4f01\u4e1a\u5efa\u7acb\u4e86\u6218\u7565\u5408\u4f5c\u5173\u7cfb\u3002\u963f\u8bfa\u533b\u836f\u81f4\u529b\u4e8e\u6210\u4e3a\u6253\u9020\u201c\u5168\u7403\u65b0\u201d\u80bf\u7624\u836f\u7269\u7684\u521b\u65b0\u578b\u7814\u53d1\u4f01\u4e1a\uff0c\u4e3a\u4e2d\u56fd\u4e43\u81f3\u5168\u7403\u60a3\u8005\u5e26\u6765\u66f4\u6709\u6548\u7684\u6cbb\u7597\u65b9\u5f0f\uff0c\u5b9e\u73b0\u5c06\u764c\u75c7\u53d8\u6210\u4e00\u79cd\u975e\u81f4\u547d\u75be\u75c5\u4e43\u81f3\u6cbb\u6108\u7684\u4f7f\u547d\u3002\u6b32\u4e86\u89e3\u66f4\u591a\uff0c\u8bf7\u8bbf\u95ee<a target=\"_blank\" href=\"http:\/\/www.adlainortye.com\/\" rel=\"nofollow noopener\">www.adlainortye.com<\/a>\u3002<\/p>\n<div>\n<table id=\"convertedTable5186\" cellspacing=\"0\" cellpadding=\"0\" border=\"1\" class=\"prntblns\">\n<tbody>\n<tr>\n<td class=\"prngen2\">\n<p class=\"prnews_p\"><span class=\"prnews_span\">\u53c2\u8003\u6587\u732e\uff1a<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\">\n<p class=\"prnews_p\"><span class=\"prnews_span\"><sup>[1]<\/sup>&nbsp;Sung, H. Ferlay, J. Siegel, R. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries, 2021 Feb 4. <\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\">\n<p class=\"prnews_p\"><span class=\"prnews_span\"><sup>[2]<\/sup> \u9648\u66e6, \u4e54\u660e\u54f2. \u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\u5728\u590d\u53d1\u6216\u8f6c\u79fb\u6027\u5934\u9888\u9cde\u764c\u7684\u6cbb\u7597\u8fdb\u5c55. \u5c71\u4e1c\u5927\u5b66\u8033\u9f3b\u5589\u5b66\u62a5. 2019\u5e745\u6708, \u7b2c33\u5377, \u7b2c3\u671f.<\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table><\/div>\n<p>\u58f0\u660e\uff1a<\/p>\n<ol type=\"1\">\n<li><i>\u8be5\u9002\u5e94\u75c7\u5c1a\u672a\u5728\u4e2d\u56fd\u83b7\u6279<\/i> <\/li>\n<li><i>\u963f\u8bfa\u533b\u836f\u4e0d\u63a8\u8350\u4efb\u4f55\u672a\u83b7\u6279\u7684\u836f\u54c1<\/i><i>\/\u9002\u5e94\u75c7\u4f7f\u7528<\/i> <\/li>\n<li><i>\u4ec5\u4f9b\u533b\u7597\u536b\u751f\u4e13\u4e1a\u4eba\u58eb\u4ea4\u6d41\u4f7f\u7528<\/i><\/li>\n<\/ol>\n<p>&nbsp;<\/p>\n<p>\u76f8\u5173\u94fe\u63a5 :<\/p>\n<p>http:\/\/www.adlainortye.com<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u5f00\u542f\u4e16\u754c\u8303\u56f4\u5185PI3K\u836f\u7269\u5728\u5934\u9888\u764c\u6cbb\u7597\u9886\u57df\u7684\u9996\u4e2a\u5168\u7403\u591a\u4e2d\u5fc3\u5927\u578bIII\u671f\u4e34\u5e8a\u8bd5\u9a8c \u4e2d\u56fd\u676d\u5dde2021\u5e744\u670815\u65e5 \/\u7f8e\u901a\u793e\/ &#8212; \u963f\u8bfa\u533b\u836f\uff0c\u4e00\u5bb6\u4e13\u6ce8\u4e8e\u80bf\u7624\u6cbb\u7597\u9886\u57df\u7684\u521b\u65b0\u578b\u5168\u7403\u751f\u7269\u5236\u836f\u516c\u53f8\uff0c\u4eca\u65e5\u5ba3\u5e03\u5176\u53e3\u670dPI3K\u6291\u5236\u5242Buparlisib\uff08AN2025\uff09\u8054\u5408\u7d2b\u6749\u9187\u7528\u4e8e\u6cbb\u7597\u590d\u53d1\u6027\u6216\u8f6c\u79fb\u6027\u5934\u9888\u90e8\u9cde\u72b6\u7ec6\u80de\u764c\u7684\u5168\u7403\u591a\u4e2d\u5fc3III\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff08\u7814\u7a76\u540d\u79f0BURAN\uff09\u5df2\u4e8e\u4e2d\u56fd\u4e0a\u6d77\u4e1c\u65b9\u533b\u9662\u6210\u529f\u5b8c\u6210\u9996\u4f8b\u60a3\u8005\u7ed9\u836f\uff0c\u5f00\u542f\u4e86\u4e16\u754c\u8303\u56f4\u5185PI3K\u836f\u7269\u5728\u5934\u9888\u764c\u6cbb\u7597\u9886\u57df\u7684\u9996\u4e2a\u5168\u7403\u591a\u4e2d\u5fc3\u5927\u578bIII\u671f\u4e34\u5e8a\u8bd5\u9a8c\u3002 \u8be5\u7814\u7a76\u662f\u4e00\u9879\u5728\u5168\u7403\u5f00\u5c55\u7684\u8bc4\u4f30Buparlisib\u8054\u5408\u7d2b\u6749\u9187\u6216\u7d2b\u6749\u9187\u5355\u72ec\u6cbb\u7597\u590d\u53d1\u6027\u6216\u8f6c\u79fb\u6027\u5934\u9888\u90e8\u9cde\u72b6\u7ec6\u80de\u764c\u7597\u6548\u548c\u5b89\u5168\u6027\u7684\u968f\u673a\u3001\u5f00\u653e\u3001\u591a\u4e2d\u5fc3\u7684III\u671f\u4e34\u5e8a\u7814\u7a76\u3002\u4e3b\u8981\u7814\u7a76\u7ec8\u70b9\u662f\u60a3\u8005\u603b\u751f\u5b58\u671f\u3002\u672c\u7814\u7a76\u8ba1\u5212\u5728\u5317\u7f8e\u3001\u6b27\u6d32\u53ca\u4e9a\u592a\u768415\u4e2a\u4e3b\u8981\u56fd\u5bb6\u548c\u5730\u533a\u4e2d\u7684150\u591a\u5bb6\u7814\u7a76\u4e2d\u5fc3\u62db\u52df\u8fd1500\u4f4d\u5934\u9888\u90e8\u9cde\u72b6\u7ec6\u80de\u764c\u60a3\u8005\uff0c\u5165\u7ec4\u6807\u51c6\u5305\u62ec\u66fe\u63a5\u53d7\u8fc7PD-1\/PD-L1\u5355\u836f\u6cbb\u7597\uff0cPD-1\/PD-L1\u8054\u7528\u94c2\u7c7b\u5316\u7597\u6216\u6309\u5e8f\u5217\u63a5\u53d7PD-1\/PD-L1\u6cbb\u7597\u548c\u542b\u94c2\u7c7b\u5316\u7597\uff08\u65e0\u8bba\u5148\u540e\u987a\u5e8f\uff09\u540e\u51fa\u73b0\u75be\u75c5\u8fdb\u5c55\u7684\u60a3\u8005\u3002 \u5934\u9888\u90e8\u9cde\u72b6\u7ec6\u80de\u764c\u7684\u5168\u7403\u53d1\u75c5\u7387\u5c45\u6076\u6027\u80bf\u7624\u7b2c\u516b\u4f4d\uff0c\u6b7b\u4ea1\u7387\u5c45\u7b2c\u5341\u4e8c\u4f4d\uff0c\u6bcf\u5e74\u65b0\u53d1\u7ea684\u4e07\u4f8b[1]\u3002\u8fd1\u5e74\u6765\uff0c\u5c3d\u7ba1\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\u7684\u51fa\u73b0\u7ed9\u5934\u9888\u90e8\u9cde\u72b6\u7ec6\u80de\u764c\u60a3\u8005\u5e26\u6765\u4e86\u663e\u8457\u7684\u4e34\u5e8a\u83b7\u76ca\uff0c\u4f46\u5176\u5355\u836f\u6216\u8054\u5408\u5316\u7597\u6cbb\u7597\u590d\u53d1\u6027\u6216\u8f6c\u79fb\u6027\u5934\u9888\u90e8\u9cde\u72b6\u7ec6\u80de\u764c\u603b\u4f53\u53cd\u5e94\u7387\u4e0d\u9ad8[2]\u3002\u5bf9\u4e8e\u4f7f\u7528\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\u540e\u6ca1\u6709\u54cd\u5e94\u6216\u51fa\u73b0\u75be\u75c5\u8fdb\u5c55\u7684\u60a3\u8005\uff0c\u76ee\u524d\u5c1a\u65e0\u5176\u4ed6\u6cbb\u7597\u9009\u62e9\u4e14\u8fd9\u7c7b\u60a3\u8005\u6570\u91cf\u6b63\u5728\u9010\u5e74\u589e\u52a0\u3002\u56e0\u6b64\uff0c\u4e34\u5e8a\u4e9f\u9700\u63a2\u7d22\u66f4\u591a\u6709\u6548\u7684\u6cbb\u7597\u65b9\u5f0f\uff0c\u63d0\u9ad8\u60a3\u8005\u6574\u4f53\u751f\u5b58\u83b7\u76ca\u3002 \u5168\u7403\u5934\u9888\u764c\u7814\u7a76\u9886\u57df\u77e5\u540d\u4e13\u5bb6\u3001\u8be5\u7814\u7a76\u7275\u5934\u4ebaDenis Souli&egrave;res\u6559\u6388\u8868\u793a\uff1a\u201c\u6b64\u524d\u5df2\u5b8c\u6210\u7684\u5168\u7403II\u671f\u4e34\u5e8a\u8bd5\u9a8c\u7ed3\u679c\u663e\u793aBuparlisib\uff08AN2025\uff09\u5177\u6709\u826f\u597d\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\uff0c\u6b64\u6b21\u5168\u7403III\u671f\u4e34\u5e8a\u8bd5\u9a8c\u7684\u76ee\u6807\u662f\u4e3a\u7ecf\u514d\u75ab\u6cbb\u7597\u6216\u514d\u75ab\u6cbb\u7597\u4e0e\u542b\u94c2\u7c7b\u5316\u7597\u8054\u5408\u4f7f\u7528\u540e\u51fa\u73b0\u8fdb\u5c55\u7684\u60a3\u8005\uff0c\u4e3a\u5176\u63d0\u4f9b\u6bd4\u7d2b\u6749\u9187\u66f4\u6709\u6548\u7684\u6cbb\u7597\u65b9\u5f0f\u3002\u201d \u201c\u5934\u9888\u90e8\u9cde\u72b6\u7ec6\u80de\u764c\u8fd1\u51e0\u5e74\u53d6\u5f97\u4e86\u5f88\u5927\u7684\u7a81\u7834\uff0c\u4f46\u5bf9\u4e8e\u590d\u53d1\u6216\u8f6c\u79fb\u6027\u7684\u60a3\u8005\u6765\u8bf4\u4ecd\u5b58\u5728\u672a\u88ab\u6ee1\u8db3\u7684\u9700\u6c42\u3002\u8be5\u7814\u7a76\u6709\u671b\u6539\u53d8\u5934\u9888\u90e8\u9cde\u72b6\u7ec6\u80de\u764c\u4e8c\u7ebf\u6cbb\u7597\u683c\u5c40\uff0c\u4e3a\u4e2d\u56fd\u53ca\u5168\u7403\u60a3\u8005\u63d0\u4f9b\u5168\u65b0\u7684\u6cbb\u7597\u9009\u62e9\u3002\u201d\u540c\u6d4e\u5927\u5b66\u9644\u5c5e\u4e1c\u65b9\u533b\u9662\u4e00\u671f\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u5fc3\u4e3b\u4efb\uff0c\u4e2d\u56fd\u4e34\u5e8a\u80bf\u7624\u5b66\u4f1a\u5934\u9888\u80bf\u7624\u4e13\u59d4\u4f1a\u4e3b\u59d4\uff0c\u90ed\u6654\u6559\u6388\u6307\u51fa\uff0c\u201c\u4f5c\u4e3a\u533b\u751f\u5f88\u6b23\u6170\u5730\u770b\u5230\u8d8a\u6765\u8d8a\u591a\u7684\u7814\u7a76\u5728\u4e2d\u56fd\u5f00\u5c55\u5e76\u53c2\u4e0e\u5176\u4e2d\uff0c\u5728\u4e2d\u56fd\u5f00\u5c55\u8bd5\u9a8c\u80fd\u7cbe\u51c6\u7684\u53cd\u6620\u4e2d\u56fd\u4eba\u7fa4\u72b6\u6001\uff0c\u4e3a\u4e34\u5e8a\u7814\u7a76\u79ef\u7d2f\u66f4\u591a\u6570\u636e\u4e0e\u7ecf\u9a8c\uff0c\u63a8\u52a8\u4e2d\u56fd\u5934\u9888\u764c\u8bca\u7597\u8fdb\u5c55\u3002\u201d \u963f\u8bfa\u533b\u836f\u9996\u5e2d\u533b\u5b66\u5b98Lars Birgerson\u535a\u58eb\u8868\u793a\uff1a\u201c\u4e0e\u4e16\u754c\u9876\u5c16\u7814\u7a76\u4eba\u5458\u5408\u4f5c\u5f00\u5c55\u4e34\u5e8a\u8bd5\u9a8c\u662f\u963f\u8bfa\u533b\u836f\u5168\u7403\u5316\u7684\u5f00\u53d1\u7b56\u7565\u4e2d\u975e\u5e38\u91cd\u8981\u7684\u90e8\u5206\u3002\u6211\u4eec\u5e0c\u671b\u963f\u8bfa\u533b\u836f\u7684\u4ea7\u54c1\u80fd\u591f\u5728\u8fd9\u6837\u7684\u5408\u4f5c\u4e0b\u9ad8\u6548\u5730\u8fdb\u5165\u5e02\u573a\uff0c\u4ee5\u60e0\u53ca\u66f4\u591a\u7684\u60a3\u8005\u53ca\u5bb6\u5ead\u3002\u6839\u636e\u6b64\u524d\u5df2\u5b8c\u6210\u7684\u5168\u7403II\u671f\u4e34\u5e8a\u8bd5\u9a8c\u7ed3\u679c\u663e\u793a\u4f7f\u7528Buparlisib\uff08AN2025\uff09\u540e\u60a3\u8005\u7684\u4e2d\u4f4d\u751f\u5b58\u671f\u9ad8\u8fbe10.4\u4e2a\u6708\uff0c\u83b7\u5f97\u4e86\u7f8e\u56fdFDA\u6388\u4e88\u7684\u5feb\u901f\u5ba1\u6279\u901a\u9053\u8d44\u683c\uff0c\u8be5\u836f\u7269\u6709\u671b\u6210\u4e3a\u5934\u9888\u764c\u6cbb\u7597\u9886\u57df\u9996\u4e2a\u4e0a\u5e02\u7684PI3K\u6291\u5236\u5242\uff0c\u4e3a\u5934\u9888\u764c\u6cbb\u7597\u5e26\u6765\u65b0\u7684\u601d\u8def\u3002\u201d \u5173\u4e8e\u5934\u9888\u90e8\u9cde\u72b6\u7ec6\u80de\u764c\u5934\u9888\u90e8\u9cde\u72b6\u7ec6\u80de\u764c\u7684\u5168\u7403\u53d1\u75c5\u7387\u5c45\u6076\u6027\u80bf\u7624\u7b2c\u516b\u4f4d\uff0c\u7ea6\u5360\u6240\u6709\u5934\u9888\u764c\u768490%\u3002&nbsp;2020\u5e74\uff0c\u5934\u9888\u90e8\u9cde\u72b6\u7ec6\u80de\u764c\u7684\u5168\u7403\u53d1\u75c5\u4eba\u6570\u7ea684\u4e07\uff0c\u9884\u8ba1\u52302030\u5e74\u5c06\u4e0a\u5347\u81f3\u7ea6100\u4e07\u3002\u6d41\u884c\u75c5\u5b66\u6570\u636e\u663e\u793a\uff0c50%-60%\u7684\u5934\u9888\u90e8\u9cde\u764c\u60a3\u8005\u5728\u786e\u8bca\u65f6\u5df2\u53d1\u5c55\u4e3a\u5c40\u90e8\u665a\u671f\uff0c\u540c\u65f650%-60%\u7684\u60a3\u8005\u5728\u4e24\u5e74\u5185\u4f1a\u51fa\u73b0\u590d\u53d1\u3002\u590d\u53d1\u6216\u8f6c\u79fb\u6027\u5934\u9888\u90e8\u9cde\u764c\u901a\u5e38\u9884\u540e\u5dee\u3001\u6b7b\u4ea1\u7387\u9ad8\u3002\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\u7684\u51fa\u73b0\u7ed9\u60a3\u8005\u5e26\u6765\u4e86\u751f\u5b58\u83b7\u76ca\uff0c\u4f46\u4e5f\u6709\u90e8\u5206\u60a3\u8005\u7ecfPD-1\/PD-L1\u6216PD-1\/PD-L1\u8054\u7528\u5316\u7597\u540e\u6ca1\u6709\u54cd\u5e94\uff0c\u4e14\u8fd9\u4e00\u90e8\u5206\u7684\u6bd4\u4f8b\u6b63\u9010\u6e10\u4e0a\u5347\u3002\u76ee\u524d\u5168\u7403\u5c1a\u65e0\u80fd\u6ee1\u8db3\u8fd9\u7c7b\u60a3\u8005\u9700\u6c42\u7684\u5019\u9009\u836f\u7269\u8fdb\u5165\u6ce8\u518c\u6027\u4e34\u5e8a\u9636\u6bb5\uff0cAN2025\u6709\u671b\u6210\u4e3a\u5168\u7403\u7b2c\u4e00\u4e2a\u4e0a\u5e02\u7684\u76f8\u5173\u836f\u7269\u3002 \u5173\u4e8eBURAN\u7814\u7a76 BURAN\u7814\u7a76\u662f\u4e00\u9879\u968f\u673a\u3001\u5f00\u653e\u3001\u591a\u4e2d\u5fc3\u7684III\u671f\u7814\u7a76\uff0c\u65e8\u5728\u8bc4\u4f30Buparlisib\uff08AN2025\uff09\uff08\u4e00\u65e5\u4e00\u6b21\uff09\u8054\u5408\u7d2b\u6749\u9187\uff08\u4e00\u5468\u4e00\u6b21\uff09\u4e0e\u7d2b\u6749\u9187\u5355\u72ec\u6cbb\u7597\uff08\u4e00\u5468\u4e00\u6b21\uff09\u590d\u53d1\u6027\u6216\u8f6c\u79fb\u6027\u5934\u9888\u90e8\u9cde\u72b6\u7ec6\u80de\u764c\uff08HNSCC\uff09\u7684\u7597\u6548\u548c\u5b89\u5168\u6027\u3002\u5165\u7ec4\u60a3\u8005\u6807\u51c6\u5305\u62ec\u66fe\u63a5\u53d7\u8fc7PD-1\/PD-L1\u5355\u836f\u6cbb\u7597\uff0cPD-1\/PD-L1\u8054\u7528\u94c2\u7c7b\u5316\u7597\u6216\u6309\u5e8f\u5217\u63a5\u53d7PD-1\/PD-L1\u6cbb\u7597\u548c\u542b\u94c2\u7c7b\u5316\u7597\uff08\u65e0\u8bba\u5148\u540e\u987a\u5e8f\uff09\u540e\u51fa\u73b0\u75be\u75c5\u8fdb\u5c55\u7684\u60a3\u8005\u3002 \u5173\u4e8eBuparlisib (AN2025)Buparlisib (AN2025)\u662f\u4e00\u79cd\u53e3\u670d\u7684\u6cdbPI3K\u6291\u5236\u5242\uff0c\u9488\u5bf9\u6240\u6709\u7684I\u7c7bPI3K\u4e9a\u578b\uff0c\u5728\u8840\u6db2\u6076\u6027\u80bf\u7624\u548c\u5b9e\u4f53\u7624\u4e2d\u5747\u8868\u73b0\u51fa\u6297\u80bf\u7624\u6d3b\u6027\u3002\u5728\u5176\u6cbb\u7597\u5934\u9888\u90e8\u9cde\u72b6\u7ec6\u80de\u764c\uff08HNSCC\uff09\u7684\u5168\u7403II\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff08BERIL-1\uff09\u4e2d\uff0c\u60a3\u8005\u7684\u4e2d\u4f4d\u751f\u5b58\u671f\u9ad8\u8fbe10.4\u4e2a\u6708\uff0c\u83b7\u7f8e\u56fdFDA\u6388\u4e88\u7684\u5feb\u901f\u5ba1\u6279\u901a\u9053\u8d44\u683c\u5e76\u83b7\u6279\u5f00\u5c55III\u671f\u4e34\u5e8a\u8bd5\u9a8c\u3002\u76ee\u524d\uff0cBuparlisib\u9488\u5bf9HNSCC\u7684\u5168\u7403\u591a\u4e2d\u5fc3III\u671f\u4e34\u5e8a\u8bd5\u9a8c\u5df2\u7ecf\u542f\u52a8\u3002 \u5173\u4e8e\u963f\u8bfa\u533b\u836f\u963f\u8bfa\u533b\u836f\u662f\u4e00\u5bb6\u4e34\u5e8a\u9636\u6bb5\u7684\u4e13\u6ce8\u4e8e\u521b\u65b0\u578b\u80bf\u7624\u836f\u7269\u5f00\u53d1\u7684\u5168\u7403\u6027\u751f\u7269\u5236\u836f\u516c\u53f8\uff0c\u5728\u4e2d\u7f8e\u4e24\u5730\u5747\u8bbe\u6709\u7814\u53d1\u53ca\u4e34\u5e8a\u8fd0\u8425\u4e2d\u5fc3\u3002\u963f\u8bfa\u533b\u836f\u901a\u8fc7\u201c\u8054\u5408\u521b\u65b0\u201d\u548c\u201c\u81ea\u4e3b\u7814\u53d1\u201d\u7684\u6a21\u5f0f\u6784\u5efa\u8d77\u4e00\u6761\u5168\u7403\u5316\u7684\u4ea7\u54c1\u7ba1\u7ebf\uff0c\u76ee\u524d\u6db5\u76d610\u4f59\u79cd\u6297\u80bf\u7624\u5019\u9009\u836f\u7269\u3002\u5176\u4e2d\u67093\u6b3e\u836f\u7269\u73b0\u5904\u4e8e\u4e34\u5e8a\u9636\u6bb5\uff0c\u5206\u522b\u662f\u5df2\u83b7\u5f97&nbsp;FDA&nbsp;\u5feb\u901f\u901a\u9053\u8d44\u683c\u7684AN2025\uff08Buparlisib\uff09\u9879\u76ee\uff0c\u6b63\u5728\u5f00\u5c55\u5168\u7403\u591a\u4e2d\u5fc33\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff1b\u540c\u6837\u83b7\u5f97&nbsp;FDA&nbsp;\u5feb\u901f\u901a\u9053\u8d44\u683c\u7684\u53ef\u901a\u8fc7\u9759\u8109\u6ce8\u5c04\u7ed9\u836f\u7684\u6eb6\u7624\u75c5\u6bd2&nbsp;AN1004\uff08Pelareorep\uff09\u9879\u76ee\uff0c\u5df2\u5b8c\u62102\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff1b\u9488\u5bf9\u591a\u79cd\u5b9e\u4f53\u7624\u73b0\u5904\u4e8e\u65e9\u671f\u4e34\u5e8a\u5f00\u53d1\u4e2d\u7684\u53e3\u670dEP4\u62ee\u6297\u5242\uff08AN0025\uff09\u9879\u76ee\uff0c\u76ee\u524d\u6b63\u5728\u5c1d\u8bd5\u4e0e\u5176\u4ed6\u6cbb\u7597\u65b9\u6848\uff08\u5305\u62ec\u5316\u653e\u7597\u548cPD-1 \/PD-L1\u6291\u5236\u5242\u7597\u6cd5\uff09\u8054\u5408\u4f7f\u7528\u3002 \u963f\u8bfa\u533b\u836f\u5df2\u7ec4\u5efa\u4e86\u4e00\u652f\u5177\u6709\u7ade\u4e89\u529b\u7684\u7ba1\u7406\u56e2\u961f\uff0c\u5e76\u642d\u5efa\u4e86\u72ec\u7279\u7684\u836f\u7269\u5f00\u53d1\u6280\u672f\u5e73\u53f0\uff0c\u540c\u65f6\u4e0e\u5168\u7403\u591a\u5bb6\u9876\u5c16\u5236\u836f\u4f01\u4e1a\u5efa\u7acb\u4e86\u6218\u7565\u5408\u4f5c\u5173\u7cfb\u3002\u963f\u8bfa\u533b\u836f\u81f4\u529b\u4e8e\u6210\u4e3a\u6253\u9020\u201c\u5168\u7403\u65b0\u201d\u80bf\u7624\u836f\u7269\u7684\u521b\u65b0\u578b\u7814\u53d1\u4f01\u4e1a\uff0c\u4e3a\u4e2d\u56fd\u4e43\u81f3\u5168\u7403\u60a3\u8005\u5e26\u6765\u66f4\u6709\u6548\u7684\u6cbb\u7597\u65b9\u5f0f\uff0c\u5b9e\u73b0\u5c06\u764c\u75c7\u53d8\u6210\u4e00\u79cd\u975e\u81f4\u547d\u75be\u75c5\u4e43\u81f3\u6cbb\u6108\u7684\u4f7f\u547d\u3002\u6b32\u4e86\u89e3\u66f4\u591a\uff0c\u8bf7\u8bbf\u95eewww.adlainortye.com\u3002 \u53c2\u8003\u6587\u732e\uff1a [1]&nbsp;Sung, H. Ferlay, J. Siegel, R. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries, 2021 Feb 4. [2] \u9648\u66e6, \u4e54\u660e\u54f2. \u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\u5728\u590d\u53d1\u6216\u8f6c\u79fb\u6027\u5934\u9888\u9cde\u764c\u7684\u6cbb\u7597\u8fdb\u5c55. \u5c71\u4e1c\u5927\u5b66\u8033\u9f3b\u5589\u5b66\u62a5. 2019\u5e745\u6708, \u7b2c33\u5377,&hellip; <a class=\"read-more\" href=\"https:\/\/www.xinwengao.com\/cn\/pr\/2021041508000026603\">Read More<\/a><\/p>\n","protected":false},"author":556,"featured_media":8278,"comment_status":"close","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1965],"tags":[],"class_list":["post-26603","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-partnerships"],"amp_enabled":true,"_links":{"self":[{"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/posts\/26603","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/users\/556"}],"replies":[{"embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/comments?post=26603"}],"version-history":[{"count":1,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/posts\/26603\/revisions"}],"predecessor-version":[{"id":26604,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/posts\/26603\/revisions\/26604"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/media\/8278"}],"wp:attachment":[{"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/media?parent=26603"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/categories?post=26603"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/tags?post=26603"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}