{"id":26083,"date":"2021-04-12T03:00:00","date_gmt":"2021-04-11T20:00:00","guid":{"rendered":"https:\/\/www.xinwengao.com\/cn\/pr\/2021041203000026083"},"modified":"2021-04-12T21:38:25","modified_gmt":"2021-04-12T13:38:25","slug":"%e7%99%be%e6%b5%8e%e7%a5%9e%e5%b7%9e%e5%9c%a8%e7%be%8e%e5%9b%bd%e7%99%8c%e7%97%87%e7%a0%94%e7%a9%b6%e5%8d%8f%e4%bc%9a%ef%bc%88aacr%ef%bc%892021%e5%b9%b4%e5%b9%b4%e4%bc%9a%e4%b8%8a%e5%85%ac%e5%b8%83sit","status":"publish","type":"post","link":"https:\/\/www.xinwengao.com\/cn\/pr\/2021041203000026083","title":{"rendered":"\u767e\u6d4e\u795e\u5dde\u5728\u7f8e\u56fd\u764c\u75c7\u7814\u7a76\u534f\u4f1a\uff08AACR\uff092021\u5e74\u5e74\u4f1a\u4e0a\u516c\u5e03Sitravatinib\u8054\u5408\u767e\u6cfd\u5b89\uff08R\uff09\u7684\u4e34\u5e8a\u6570\u636e"},"content":{"rendered":"<ul type=\"disc\">\n<li><i>\u4e00\u9879\u6b63\u5728\u5f00\u5c55\u7684<\/i><i>sitravatinib<\/i><i>\u8054\u5408\u767e\u6cfd\u5b89<\/i><i><sup>&reg;<\/sup><\/i><i>\u7684<\/i><i>&nbsp;1b <\/i><i>\u671f\u4e34\u5e8a\u8bd5\u9a8c\u6570\u636e\u663e\u793a\uff0c\u8be5\u7ec4\u5408\u7528\u836f\u9488\u5bf9<\/i><i>PD-1\/PD-L1 <\/i><i>\u7597\u6cd5\u96be\u6cbb\u6027\u6216\u8010\u836f\u6027\u7684\u4e0d\u53ef\u5207\u9664\u6216\u8f6c\u79fb\u6027\u9ed1\u8272\u7d20\u7624\u60a3\u8005\u548c\u94c2\u7c7b\u8010\u836f\u5375\u5de2\u764c\u60a3\u8005\u5177\u6709\u521d\u6b65\u6297\u80bf\u7624\u6d3b\u6027\u4e14\u603b\u4f53\u8010\u53d7<\/i><\/li>\n<\/ul>\n<p><p>\u7f8e\u56fd\u9ebb\u7701\u5251\u6865\u548c\u4e2d\u56fd\u5317\u4eac2021\u5e744\u670812\u65e5 \/\u7f8e\u901a\u793e\/ &#8212; 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Inc.\u5408\u4f5c\u5f00\u53d1\u7684\u5728\u7814\u9009\u62e9\u6027\u6fc0\u9176\u6291\u5236\u5242&nbsp;sitravatinib\u7684\u4e34\u5e8a\u6570\u636e\u3002\u5728\u5e74\u4f1a\u4e0a\u516c\u5e03\u7684\u6570\u636e\u6765\u81ea\u4e00\u98791b\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff08NCT03666143\uff09\u7684\u4e24\u4e2a\u961f\u5217\uff0c\u5206\u522b\u7528\u4e8e\u6cbb\u7597PD-1\/PD-L1 \u7597\u6cd5\u96be\u6cbb\u6027\u6216\u8010\u836f\u6027\u7684\u4e0d\u53ef\u5207\u9664\u6216\u8f6c\u79fb\u6027\u9ed1\u8272\u7d20\u7624\u60a3\u8005\u4ee5\u53ca\u7528\u4e8e\u6cbb\u7597\u665a\u671f\u94c2\u7c7b\u8010\u836f\u5375\u5de2\u764c\uff08PROC\uff09\u60a3\u8005\u3002<\/p>\n<p>\u767e\u6d4e\u795e\u5dde\u5148\u524d\u4e0eMirati Therapeutics, Inc.\u8fbe\u6210\u72ec\u5bb6\u5408\u4f5c\u548c\u6388\u6743\u534f\u8bae\uff0c\u5728\u4e9a\u6d32\uff08\u4e0d\u5305\u62ec\u65e5\u672c\uff09\u3001\u6fb3\u5927\u5229\u4e9a\u548c\u65b0\u897f\u5170\u5171\u540c\u5f00\u53d1\u3001\u751f\u4ea7\u548c\u5546\u4e1a\u5316sitravatinib\u3002<\/p>\n<p>\u767e\u6d4e\u795e\u5dde\u80bf\u7624\u514d\u75ab\u5b66\u9996\u5e2d\u533b\u5b66\u5b98\u8d32\u52c7\u533b\u5b66\u535a\u58eb\u8868\u793a\uff1a\u201c\u4ece\u4eca\u5929\u516c\u5e03\u7684\u6570\u636e\u6765\u770b\uff0c\u6211\u4eec\u8ba4\u4e3asitravatinib\u8054\u5408\u767e\u6cfd\u5b89<sup>&reg;<\/sup>\u6709\u671b\u4e3a\u665a\u671f\u5b9e\u4f53\u7624\u60a3\u8005\u63d0\u4f9b\u4e34\u5e8a\u76ca\u5904\uff0c\u5e76\u652f\u6301\u6211\u4eec\u5728\u6b63\u5728\u5f00\u5c55\u7684\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u8fdb\u4e00\u6b65\u8bc4\u4f30\u8fd9\u9879\u7ec4\u5408\u7528\u836f\u3002\u6b64\u5916\uff0c\u6211\u4eec\u5f88\u5174\u594b\u5730\u5728PD-1\/PD-L1 \u7597\u6cd5\u96be\u6cbb\u6027\u6216\u8010\u836f\u6027\u9ed1\u8272\u7d20\u7624\u60a3\u8005\u4e2d\u89c2\u5bdf\u5230\u4e86\u521d\u6b65\u6297\u80bf\u7624\u6d3b\u6027\u3002\u6211\u4eec\u5c06\u7ee7\u7eed\u5bf9\u60a3\u8005\u8fdb\u884c\u968f\u8bbf\u5e76\u5b8c\u6210\u8bd5\u9a8c\u7684\u5168\u90e8\u60a3\u8005\u5165\u7ec4\uff0c\u4e5f\u671f\u5f85\u540c\u65f6\u4e0d\u65ad\u52a0\u6df1\u5bf9\u8be5\u7ec4\u5408\u7528\u836f\u7684\u8ba4\u77e5\uff0c\u4e3a\u4e16\u754c\u5404\u5730\u7684\u60a3\u8005\u63d0\u4f9b\u4e00\u6b3e\u65b0\u578b\u6297\u51fb\u764c\u75c7\u7684\u7597\u6cd5\u3002\u201d<\/p>\n<p>\u8fd9\u9879\u5f00\u653e\u6027\u3001\u591a\u4e2d\u5fc3\u76841b \u671f\u4e34\u5e8a\u8bd5\u9a8c\u65e8\u5728\u8bc4\u4f30sitravatinib \u8054\u5408\u767e\u6cfd\u5b89<sup>&reg;<\/sup>\u9488\u5bf9\u665a\u671f\u5b9e\u4f53\u7624\u60a3\u8005\u7684\u5b89\u5168\u6027\/\u8010\u53d7\u6027\u548c\u521d\u6b65\u6297\u80bf\u7624\u6d3b\u6027\u3002\u8bd5\u9a8c\u7684\u4e3b\u8981\u7ec8\u70b9\u4e3a\u8be5\u9879\u7ec4\u5408\u7528\u836f\u7684\u5b89\u5168\u6027\/\u8010\u53d7\u6027\uff1b\u5173\u952e\u6b21\u8981\u7ec8\u70b9\u5305\u62ec\u7ecf\u7814\u7a76\u8005\u57fa\u4e8e\u5b9e\u4f53\u7624\u7597\u6548\u8bc4\u4ef7\u6807\u51c6\uff08RECIST 1.1) \u8bc4\u4f30\u7684\u5ba2\u89c2\u7f13\u89e3\u7387\uff08ORR\uff09\u3001\u75be\u75c5\u63a7\u5236\u7387\uff08DCR\uff09\u548c\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff08PFS\uff09\u3002\u6b64\u5916\uff0c\u8be5\u8bd5\u9a8c\u4e5f\u5bf9\u603b\u751f\u5b58\u671f\uff08OS\uff09\u8fdb\u884c\u8bc4\u4f30\u3002<\/p>\n<p><b>\u9488\u5bf9<\/b><b>PD-1\/PD-L1 <\/b><b>\u6291\u5236\u5242\u7597\u6cd5\u96be\u6cbb\u6027\u6216\u8010\u836f\u6027\u7684\u4e0d\u53ef\u5207\u9664\u6216\u8f6c\u79fb\u6027\u9ed1\u8272\u7d20\u7624\u60a3\u8005\u7684\u8bd5\u9a8c\u7ed3\u679c<\/b><\/p>\n<p>\u5317\u4eac\u80bf\u7624\u533b\u9662\u5d14\u4f20\u4eae\u6559\u6388\u8868\u793a\uff1a\u201c\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\u7684\u51fa\u73b0\u6539\u53d8\u4e86\u9488\u5bf9\u665a\u671f\u9ed1\u8272\u7d20\u7624\u7684\u6cbb\u7597\u65b9\u6cd5\uff0c\u4f46\u7531\u4e8e\u539f\u53d1\u6027\u6216\u5148\u5929\u6027\u8010\u836f\uff0c\u5f88\u5927\u4e00\u90e8\u5206\u60a3\u8005\u65e0\u6cd5\u4ece\u4e2d\u83b7\u76ca\u3002\u5728\u8fd9\u98791b\u671f\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\uff0c\u6211\u4eec\u5f88\u9ad8\u5174\u5730\u770b\u5230sitravatinib \u8054\u5408\u767e\u6cfd\u5b89<sup>&reg;<\/sup>\u9488\u5bf9PD-1\/L1\u8010\u836f\u6027\u9ed1\u8272\u7d20\u7624\u60a3\u8005\u603b\u4f53\u8010\u53d7\u826f\u597d\uff0c\u5e76\u4e14\u5c55\u73b0\u4e86\u521d\u6b65\u6297\u80bf\u7624\u6d3b\u6027\uff0c\u8fd9\u4e00\u70b9\u5341\u5206\u4ee4\u4eba\u9f13\u821e\u3002\u201d<\/p>\n<p>\u622a\u81f3\u6570\u636e\u622a\u70b92020\u5e7410\u670813\u65e5\uff0c\u5171\u670925\u4f8b\u5148\u524dPD-1\/PD-L1 \u7597\u6cd5\u96be\u6cbb\u6027\u6216\u8010\u836f\u6027\u4e14\u672a\u63a5\u53d7\u8fc7\u5176\u4ed6\u514d\u75ab\u7597\u6cd5\u7684\u7684\u4e0d\u53ef\u5207\u9664\u6216\u8f6c\u79fb\u6027\u9ed1\u8272\u7d20\u7624\u60a3\u8005\u5165\u7ec41b\u671f\u8bd5\u9a8cG\u961f\u5217\uff0c\u5176\u4e2d\u5305\u62ec12\u4f8b\u76ae\u80a4\u578b\u30017\u4f8b\u80a2\u7aef\u578b\u548c4\u4f8b\u9ecf\u819c\u578b\u60a3\u8005\u3002\u622a\u81f3\u6570\u636e\u622a\u70b9\uff0c16\u4f8b\u60a3\u8005\uff0864%\uff09\u4ecd\u5728\u63a5\u53d7\u7814\u7a76\u6cbb\u7597\u3002\u5728\u4e2d\u4f4d\u968f\u8bbf\u65f6\u95f4\u4e3a5.5\u6708\u65f6\uff0c\u7ed3\u679c\u5305\u62ec\uff1a<\/p>\n<ul type=\"disc\">\n<li>\u5168\u90e8 25 \u4f8b\u60a3\u8005\u5747\u7ecf\u5386\u4e86\u81f3\u5c11\u4e00\u8d77\u4efb\u4e00\u7ea7\u522b\u7684\u6cbb\u7597\u671f\u95f4\u51fa\u73b0\u7684\u4e0d\u826f\u4e8b\u4ef6\uff08TEAE\uff09\u3002\u6700\u5e38\u89c1\uff08\u226520%\uff09\u7684\u4e3a\u8c37\u4e19\u8f6c\u6c28\u9176\uff08ALT\uff09\u5347\u9ad8\uff0876%\uff09\u3001\u8c37\u8349\u8f6c\u6c28\u9176\uff08AST\uff09\u5347\u9ad8\uff0868%\uff09\u3001\u80c6\u56fa\u9187\u5347\u9ad8\uff0856%\uff09\u3001\u8840\u9ad8\u7518\u6cb9\u4e09\u916f\u5347\u9ad8\uff0852%\uff09\u3001\u7532\u72b6\u817a\u529f\u80fd\u51cf\u9000\uff0848%\uff09\u3001\u4f53\u91cd\u51cf\u8f7b\uff0848%\uff09\u3001\u8840\u808c\u9178\u6fc0\u9176\u5347\u9ad8\uff08BCK; 40%\uff09\u3001\u8179\u6cfb\uff0840%\uff09\u3001\u03b3-\u8c37\u6c28\u9170\u8f6c\u79fb\u9176\u5347\u9ad8\uff08GGT; 40%\uff09\u3001\u86cb\u767d\u5c3f\uff0840%\uff09\u3001\u8840\u80c6\u7ea2\u7d20\u5347\u9ad8\uff08BB; 36%\uff09\u3001\u5fc3\u7535\u56feT\u6ce2\u5f02\u5e38\uff0836%\uff09\u3001\u9ad8\u8840\u538b\uff0836%\uff09\u3001\u638c\u8dbe\u7ea2\u6591\u611f\u89c9\u5f02\u5e38\u7efc\u5408\u75c7\uff0832%\uff09\u3001\u808c\u9178\u6fc0\u9176-\u5fc3\u808c\u540c\u5de5\u9176\u5347\u9ad8\uff08CK-MB; 28%\uff09\u3001\u9ad8\u5c3f\u9178\u8840\u75c7\uff0828%\uff09\u3001\u4e0a\u8179\u75db\uff0824%\uff09\u3001\u5455\u5410\uff0824%\uff09\u548c\u4f4e\u94be\u8840\u75c7\uff0820%\uff09 <\/li>\n<li>12 \u4f8b\u60a3\u8005\uff0848%\uff09\u7ecf\u5386\u4e86\u81f3\u5c11\u4e00\u8d773\u7ea7\u53ca\u4ee5\u4e0a\u7684 TEAE\uff0c\u6700\u5e38\u89c1\uff08\u22655%\uff09\u4e3a\u9ad8\u8840\u538b\uff0812%\uff09\u3001ALT\u5347\u9ad8\uff088%\uff09\u548cGGT\u5347\u9ad8\uff088%\uff09 <\/li>\n<li>1\u4f8b\u60a3\u8005\uff084%\uff09\u7ecf\u5386\u4e86\u809b\u95e8\u8113\u80bf\u7684\u4e25\u91cdTEAE\uff0c\u7ecf\u8ba4\u5b9a\u4e0esitravatinib\u76f8\u5173 <\/li>\n<li>2\u4f8b\u60a3\u8005\uff088%\uff09\u7531\u4e8e TEAE \u4e2d\u65ad\u8bd5\u9a8c\u6cbb\u7597\uff1b1\u4f8b\u56e0\u9634\u9053\u51fa\u8840\u800c\u7ec8\u6b62\u767e\u6cfd\u5b89<sup>&reg;<\/sup>\u6cbb\u7597\uff08\u4e0e\u767e\u6cfd\u5b89<sup>&reg;<\/sup>\u65e0\u5173\uff09\uff0c\u53e61\u4f8b\u7531\u4e8eBCK\u5347\u9ad8\u800c\u7ec8\u6b62sitravatinib\u6cbb\u7597\uff08\u4e0esitravatinib\u6709\u5173\uff09 <\/li>\n<li>\u5206\u522b\u670918\u4f8b\u60a3\u8005\uff0872%\uff09\u548c13\u4f8b\u60a3\u8005\uff0852%\uff09\u7ecf\u5386\u4e86sitravatinib\u5242\u91cf\u4e2d\u65ad\u6216\u51cf\u5c11 <\/li>\n<li>\u6240\u670925\u4f8b\u60a3\u8005\u5747\u7eb3\u5165\u6709\u6548\u6027\u8bc4\u4f30\uff0c \u7ecf\u786e\u8ba4\u7684ORR\u4e3a24%\uff0895% CI\uff1a9.4\uff0c45.1\uff09\uff0c\u5176\u4e2d6\u4f8b\u60a3\u8005\u8fbe\u5230\u4e86\u90e8\u5206\u7f13\u89e3\uff08PR\uff09\uff0cDCR\u4e3a88%\uff0895% CI\uff1a68.8\uff0c97.5\uff09 <\/li>\n<li>\u4e2d\u4f4d\u6301\u7eed\u7f13\u89e3\u65f6\u95f4\uff08DoR\uff09\u5c1a\u672a\u8fbe\u5230\uff0c\u7ecf\u7814\u7a76\u8005\u8bc4\u4f30\u7684\u4e2d\u4f4dPFS\u4e3a 6.7\u4e2a\u6708\uff0895% CI\uff1a4.07\uff0c\u672a\u80fd\u8bc4\u4f30\uff09<\/li>\n<\/ul>\n<p><b>\u9488\u5bf9\u665a\u671f<\/b><b>PROC<\/b><b>\u60a3\u8005\u7684\u8bd5\u9a8c\u7ed3\u679c<\/b><\/p>\n<p>\u6fb3\u5927\u5229\u4e9a&nbsp;Icon \u764c\u75c7\u4e2d\u5fc3\u5185\u5916\u5168\u79d1\u533b\u5b66\u58ebJeffrey Goh\u8868\u793a\uff1a\u201c\u5375\u5de2\u764c\u60a3\u8005\u5728\u63a5\u53d7\u5f53\u524d\u6807\u51c6\u6cbb\u7597\u540e\u5bf9\u94c2\u7c7b\u7597\u6cd5\u4ea7\u751f\u8010\u836f\u6027\u6216\u96be\u6cbb\u6027\u5341\u5206\u5e38\u89c1\u3002Sitravatinib \u8054\u5408\u767e\u6cfd\u5b89<sup>&reg;<\/sup>\u7528\u4e8e\u6cbb\u7597\u5305\u62ec\u5148\u524d\u63a5\u53d7\u8fc7\u591a\u9879\u7597\u6cd5\u7684\u665a\u671fPROC\u60a3\u8005\u65f6\uff0c\u5747\u4f53\u73b0\u4e86\u521d\u6b65\u6297\u80bf\u7624\u6d3b\u6027\u4e14\u603b\u4f53\u8010\u53d7\u826f\u597d\u3002\u867d\u7136\u76ee\u524d\u60a3\u8005\u6837\u672c\u76f8\u5bf9\u8f83\u5c0f\uff0c\u4f46\u662f\u6211\u4eec\u671f\u5f85\u8fd9\u9879\u5168\u65b0\u7684\u7ec4\u5408\u7528\u836f\u5728PROC\u4e2d\u8fdb\u4e00\u6b65\u8bc4\u4f30\u3002\u201d<\/p>\n<p>\u622a\u81f3\u6570\u636e\u622a\u70b92020\u5e7410\u670813\u65e5\uff0c\u5171\u6709&nbsp;60 \u4f8b\u5148\u524d\u672a\u63a5\u53d7\u8fc7\u6297&nbsp;PD-1\/PD-L1 \u6cbb\u7597\u7684\u590d\u53d1\u6027PROC\u60a3\u8005\u5165\u7ec4\u4e861b\u671f\u8bd5\u9a8c\u7684&nbsp;E 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20%\uff09\u3001\u53d1\u58f0\u56f0\u96be\uff0820%\uff09\u3001\u5934\u75db\uff0820%\uff09\u548c\u638c\u8dbe\u7ea2\u6591\u611f\u89c9\u5f02\u5e38\u7efc\u5408\u75c7\uff0820%\uff09 <\/li>\n<li>41\u4f8b\u60a3\u8005\uff0868%\uff09\u7ecf\u5386\u4e86\u81f3\u5c11\u4e00\u8d773\u7ea7\u53ca\u4ee5\u4e0a\u7684 TEAE\uff0c\u6700\u5e38\u89c1\uff08\u22655%\uff09\u4e3a\u9ad8\u8840\u538b\uff0818%\uff09\u548c\u8179\u75db\uff0812%\uff09 <\/li>\n<li>42\u4f8b\u60a3\u8005\uff0870%\uff09\u7ecf\u5386\u4e86\u81f3\u5c111\u8d77\u4e25\u91cdTEAE <\/li>\n<li>23\u4f8b\u60a3\u8005\uff0838%\uff09\u7531\u4e8e TEAE \u4e2d\u65ad\u8bd5\u9a8c\u6cbb\u7597\uff0c\u5176\u4e2d9\u4f8b\uff0815%\uff09\u4e2d\u65ad\u767e\u6cfd\u5b89<sup>&reg;<\/sup>\u6cbb\u7597\u300114\u4f8b\uff0823%\uff09\u4e2d\u65adsitravatinib\u6cbb\u7597 <\/li>\n<li>\u5206\u522b\u670950\u4f8b\u60a3\u8005\uff0883%\uff09\u548c30\u4f8b\u60a3\u8005\uff0850%\uff09\u7ecf\u5386\u4e86sitravatinib\u5242\u91cf\u4e2d\u65ad\u6216\u51cf\u5c11 <\/li>\n<li>4\u4f8b\u60a3\u8005\u7531\u4e8e TEAE \u6b7b\u4ea1\uff0c\u5747\u8ba4\u5b9a\u4e0e\u8bd5\u9a8c\u6cbb\u7597\u65e0\u5173 <\/li>\n<li>\u5728\u7eb3\u5165\u6709\u6548\u6027\u8bc4\u4f30\u768453\u4f8b\u60a3\u8005\u4e2d\uff0c\u7ecf\u786e\u8ba4\u7684ORR\u4e3a26%\uff0895% CI\uff1a15.3\uff0c40.3\uff09\uff0c\u5176\u4e2d14\u4f8b\u60a3\u8005\u8fbe\u5230\u4e86PR\uff0cDCR\u4e3a77%\uff0895% CI\uff1a63.8, 87.7\uff09 <\/li>\n<li>\u4e2d\u4f4dDoR\u4e3a4.7\u4e2a\u6708\uff0895% CI\uff1a2.8, \u672a\u80fd\u8bc4\u4f30\uff09 <\/li>\n<li>\u4e2d\u4f4dPFS\u548cOS\u5206\u522b\u4e3a 4.1\u4e2a\u6708\uff0895% CI\uff1a4.0, 5.1\uff09\u548c12.9 \u4e2a\u6708\uff0895% CI: 6.3, 17.2\uff09<\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>\u4e00\u9879\u6b63\u5728\u5f00\u5c55\u7684sitravatinib\u8054\u5408\u767e\u6cfd\u5b89&reg;\u7684&nbsp;1b \u671f\u4e34\u5e8a\u8bd5\u9a8c\u6570\u636e\u663e\u793a\uff0c\u8be5\u7ec4\u5408\u7528\u836f\u9488\u5bf9PD-1\/PD-L1 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