{"id":26079,"date":"2021-04-12T07:30:00","date_gmt":"2021-04-12T00:30:00","guid":{"rendered":"https:\/\/www.xinwengao.com\/cn\/pr\/2021041207300026079"},"modified":"2021-04-12T21:38:19","modified_gmt":"2021-04-12T13:38:19","slug":"%e6%ad%8c%e7%a4%bc%e5%ae%a3%e5%b8%83%e9%9d%9e%e9%85%92%e7%b2%be%e6%80%a7%e8%84%82%e8%82%aa%e6%80%a7%e8%82%9d%e7%82%8e%e5%92%8c%e4%b9%99%e8%82%9d%e9%a2%86%e5%9f%9f%e5%9b%9b%e7%af%87%e4%b8%b4%e5%ba%8a","status":"publish","type":"post","link":"https:\/\/www.xinwengao.com\/cn\/pr\/2021041207300026079","title":{"rendered":"\u6b4c\u793c\u5ba3\u5e03\u975e\u9152\u7cbe\u6027\u8102\u80aa\u6027\u809d\u708e\u548c\u4e59\u809d\u9886\u57df\u56db\u7bc7\u4e34\u5e8a\u548c\u4e34\u5e8a\u524d\u7814\u7a76\u6458\u8981\u5165\u90092021\u5e74\u6b27\u6d32\u56fd\u9645\u809d\u75c5\u5927\u4f1a\u58c1\u62a5\u5c55\u793a"},"content":{"rendered":"<p><p>\u4e2d\u56fd\u676d\u5dde\u548c\u7ecd\u51742021\u5e744\u670812\u65e5 \/\u7f8e\u901a\u793e\/ &#8212; \u6b4c\u793c\u5236\u836f\u6709\u9650\u516c\u53f8\uff08\u9999\u6e2f\u8054\u4ea4\u6240\u4ee3\u7801\uff1a1672\uff09\u4eca\u65e5\u5ba3\u5e03\uff0c\u516c\u53f8\u5728\u975e\u9152\u7cbe\u6027\u8102\u80aa\u6027\u809d\u708e\u548c\u4e59\u809d\u9886\u57df\u7684\u56db\u7bc7\u4e34\u5e8a\u548c\u4e34\u5e8a\u524d\u7814\u7a76\u6458\u8981\u5165\u90092021\u5e74\u6b27\u6d32\u809d\u810f\u7814\u7a76\u5b66\u4f1a\uff08EASL\uff09\u5e74\u4f1a\u66a8\u56fd\u9645\u809d\u75c5\u5927\u4f1a\uff08The International Liver Congress&#x2122; 2021, ILC 2021\uff09\u7684\u58c1\u62a5\u5c55\u793a\u3002\u4ee5\u4e0b\u4e3a4\u7bc7\u6458\u8981\u7684\u6982\u8981\u4fe1\u606f\uff1a<\/p>\n<p><b>1<\/b><b>\u3001\u6807\u9898\uff1a\u809d\u810f\u9776\u5411<\/b><b>THR-\u03b2<\/b><b>\u6fc0\u52a8\u5242<\/b><b>ASC41<\/b><b>\u53e3\u670d\u7247\u5177\u6709\u663e\u8457\u964d\u8102\u4f5c\u7528\uff1a\u4e00\u9879<\/b><b>&nbsp;<\/b><b>\u2160 <\/b><b>\u671f\u968f\u673a\u3001\u53cc\u76f2\u3001\u5b89\u6170\u5242\u5bf9\u7167\u5355\u5242\u91cf\u548c\u591a\u5242\u91cf\u9012\u589e\u7814\u7a76<\/b><\/p>\n<p><b>\u6458\u8981<\/b><b>\/<\/b><b>\u6d77\u62a5\u7f16\u53f7<\/b>\uff1a1851<\/p>\n<p><b>\u7c7b\u522b<\/b>\uff1a\u975e\u9152\u7cbe\u6027\u8102\u80aa\u6027\u809d\u75c5\u6cbb\u7597<\/p>\n<p><b>\u7ed3\u679c<\/b>\uff1a\u5728\u5355\u5242\u91cf\u9012\u589e\u7684\u7814\u7a76\u4e2d\uff0c\u968f\u7740\u7ed9\u836f\u5242\u91cf\u4ece1 mg\u523020 mg\uff0cASC41\u7684\u836f\u4ee3\u52a8\u529b\u5b66\u7279\u5f81\u5448\u7ebf\u6027\u5173\u7cfb\uff0c\u4e14\u5728\u9ad8\u8fbe20 mg\u7684\u5242\u91cf\u7ec4\u4e2d\u4ecd\u8868\u73b0\u51fa\u826f\u597d\u7684\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\u3002\u5728\u591a\u5242\u91cf\u9012\u589e\u7684\u4e34\u5e8a\u7814\u7a76\u4e2d\uff0c\u7ecf\u8fc714\u5929\u6bcf\u65e5\u53e3\u670d\u4e00\u6b21ASC41\u7247\u5242\u6cbb\u7597\u540e\uff0c\u7ed9\u836f\u7ec4\u53d7\u8bd5\u8005\u7684\u4f4e\u5bc6\u5ea6\u8102\u86cb\u767d\u80c6\u56fa\u9187\uff08LDL-C\uff09\u548c\u7518\u6cb9\u4e09\u916f\uff08TG\uff09\u6307\u6807\u76f8\u5bf9\u5b89\u6170\u5242\u7ec4\u8868\u73b0\u51fa\u5177\u6709\u4e34\u5e8a\u610f\u4e49\u548c\u7edf\u8ba1\u5b66\u663e\u8457\u6027\u7684\u964d\u4f4e\uff0c\u5982\u4e0b\u8868\u6240\u793a\uff1a<\/p>\n<div>\n<table cellspacing=\"0\" cellpadding=\"0\" border=\"1\" class=\"prntblns\">\n<tbody>\n<tr>\n<td colspan=\"4\" class=\"prnsbts prnrbrs prnvab prnsbbs prnpl6 prnsbls prnpr6\">\n<p class=\"prnews_p\"><span class=\"prnews_span\">\u53bb\u9664\u5b89\u6170\u5242\u6548\u5e94\u540e\uff0c\u7ecf\u8fc714\u5929\u6bcf\u65e5\u53e3\u670d\u4e00\u6b21ASC41\u7247\u5242\u6cbb\u7597\u540e\u76f8\u5bf9\u57fa\u7ebf\u53d8\u5316\uff08\u5e73\u5747\u503c\uff09<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen3\"><\/td>\n<td class=\"prngen4\">\n<p class=\"prnews_p\"><span class=\"prnews_span\">1 mg<\/span><\/p>\n<p class=\"prnews_p\"><span class=\"prnews_span\">(n=12)<\/span><\/p>\n<\/td>\n<td class=\"prngen4\">\n<p class=\"prnews_p\"><span class=\"prnews_span\">2 mg<\/span><\/p>\n<p class=\"prnews_p\"><span class=\"prnews_span\">(n=12)<\/span><\/p>\n<\/td>\n<td class=\"prngen4\">\n<p class=\"prnews_p\"><span class=\"prnews_span\">5 mg<\/span><\/p>\n<p class=\"prnews_p\"><span class=\"prnews_span\">(n=12)<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen3\">\n<p class=\"prnews_p\"><span class=\"prnews_span\">\u53bb\u9664\u5b89\u6170\u5242\u6548\u5e94\u540e\uff0c\u4f4e\u5bc6\u5ea6\u8102\u86cb\u767d\u80c6\u56fa\u9187\uff08LDL-C\uff09\u964d\u4f4e<\/span><\/p>\n<p class=\"prnews_p\"><span class=\"prnews_span\"><i>P<\/i>\u503c&nbsp;vs \u5b89\u6170\u5242<\/span><\/p>\n<\/td>\n<td class=\"prngen4\">\n<p class=\"prnews_p\"><span class=\"prnews_span\">-0.42%<\/span><\/p>\n<p class=\"prnews_p\"><span class=\"prnews_span\"><i>P<\/i>=0.947<\/span><\/p>\n<\/td>\n<td class=\"prngen4\">\n<p class=\"prnews_p\"><span class=\"prnews_span\">-11.94%<\/span><\/p>\n<p class=\"prnews_p\"><span class=\"prnews_span\"><i>P<\/i>=0.052<\/span><\/p>\n<\/td>\n<td class=\"prngen4\">\n<p class=\"prnews_p\"><span class=\"prnews_span\">-19.99%<\/span><\/p>\n<p class=\"prnews_p\"><span class=\"prnews_span\"><i>P<\/i>=0.002<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen3\">\n<p class=\"prnews_p\"><span class=\"prnews_span\">\u53bb\u9664\u5b89\u6170\u5242\u6548\u5e94\u540e\uff0c\u7518\u6cb9\u4e09\u916f\uff08TG\uff09\u964d\u4f4e<\/span><\/p>\n<p class=\"prnews_p\"><span class=\"prnews_span\"><i>P<\/i>\u503c&nbsp;vs \u5b89\u6170\u5242<\/span><\/p>\n<\/td>\n<td class=\"prngen4\">\n<p class=\"prnews_p\"><span class=\"prnews_span\">-39.43%<\/span><\/p>\n<p class=\"prnews_p\"><span class=\"prnews_span\"><i>P<\/i>=0.002<\/span><\/p>\n<\/td>\n<td class=\"prngen4\">\n<p class=\"prnews_p\"><span class=\"prnews_span\">-31.06%<\/span><\/p>\n<p class=\"prnews_p\"><span class=\"prnews_span\"><i>P<\/i>=0.029<\/span><\/p>\n<\/td>\n<td class=\"prngen4\">\n<p class=\"prnews_p\"><span class=\"prnews_span\">-34.49%<\/span><\/p>\n<p class=\"prnews_p\"><span class=\"prnews_span\"><i>P<\/i>=0.015<\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table><\/div>\n<p>\u572814\u5929\u6cbb\u7597\u4e2d\uff0cASC41\u5728\u6240\u6709\u5242\u91cf\u7ec4\u4e2d\u65e03\u7ea7\u6216\u4ee5\u4e0a\u4e0d\u826f\u4e8b\u4ef6\u3001\u4e25\u91cd\u4e0d\u826f\u4e8b\u4ef6\u6216\u63d0\u524d\u505c\u836f\u4e8b\u4ef6\u53d1\u751f\u3002\u572814\u5929\u6bcf\u65e5\u53e3\u670d\u4e00\u6b21ASC41\u7247\u5242\u7684\u7814\u7a76\u4e2d\uff0c\u968f\u7740\u7ed9\u836f\u5242\u91cf\u4ece1 mg\u589e\u52a0\u52305 mg\uff0cASC41\u7247\u5242\u7684\u836f\u4ee3\u52a8\u529b\u5b66\u7279\u5f81\u5448\u7ebf\u6027\u5173\u7cfb\u3002<\/p>\n<p><b>\u7ed3\u8bba\uff1a<\/b>\u8fd9\u4e9b\u6570\u636e\u652f\u6301ASC41\u5728\u975e\u9152\u7cbe\u6027\u8102\u80aa\u6027\u809d\u708e\u9002\u5e94\u75c7\u4e0a\u5f00\u5c55\u540e\u671f\u4e34\u5e8a\u8bd5\u9a8c\u3002<\/p>\n<p><b>2<\/b><b>\u3001\u6807\u9898\uff1a\u9009\u62e9\u6027<\/b><b>THR-<\/b><b>\u03b2\u6fc0\u52a8\u5242<\/b><b>ASC41<\/b><b>\u5bf9\u9ad8\u8102\u996e\u98df\u5bfc\u81f4\u60a3\u6709\u975e\u9152\u7cbe\u6027\u8102\u80aa\u6027\u809d\u708e\u7684\u5927\u9f20\u975e\u9152\u7cbe\u6027\u8102\u80aa\u6027\u809d\u6d3b\u52a8\u79ef\u5206\u548c\u809d\u7ea4\u7ef4\u5316\u8bc4\u5206\u7684\u663e\u8457\u6539\u5584<\/b><\/p>\n<p><b>\u6458\u8981<\/b><b>\/<\/b><b>\u6d77\u62a5\u7f16\u53f7<\/b>\uff1a1908<\/p>\n<p><b>\u7c7b\u522b<\/b>\uff1a\u975e\u9152\u7cbe\u6027\u8102\u80aa\u6027\u809d\u75c5\u6cbb\u7597<\/p>\n<p><b>\u7ed3\u679c<\/b>\uff1aASC41\u5bf9\u6539\u5584\u809d\u8102\u80aa\u53d8\u6027\u3001\u708e\u6027\u7ec6\u80de\u6d78\u6da6\u3001\u6c14\u7403\u6837\u53d8\u548c\u975e\u9152\u7cbe\u6027\u8102\u80aa\u809d\u6d3b\u52a8\u79ef\u5206\uff08NAS\uff09\u5448\u5242\u91cf\u4f9d\u8d56\u6027\u30021.5mg\/kg\u548c4.5mg\/kg\u5242\u91cf\u7684ASC41\u76f8\u6bd4\u8f835mg\/kg\u5242\u91cf\u7684MGL3196\u5242\u91cf\u663e\u8457\u6539\u5584NAS\u79ef\u5206\uff0c\u4e24\u8005\u95f4\u5177\u6709\u7edf\u8ba1\u5b66\u5dee\u5f02\u3002ASC41\u57280.5mg\/kg\u65f6\uff0cNAS\u79ef\u5206\u964d\u4f4e23.9%\uff0c\u809d\u7ea4\u7ef4\u5316\u8bc4\u5206\u964d\u4f4e14.4%\uff0c\u4e0e5 mg\/kg\u65f6\u7684MGL196\u76f8\u5f53\u3002ASC41\u57281.5mg\/kg\u548c4.5mg\/kg\u65f6\u5747\u663e\u793a\u51fa\u8840\u6e05\u4f4e\u5bc6\u5ea6\u8102\u86cb\u767d\u7684\u663e\u8457\u964d\u4f4e\u3002<\/p>\n<p><b>\u7ed3\u8bba<\/b>\uff1aASC41\u5bf9\u9ad8\u8102\u996e\u98df\u5bfc\u81f4\u60a3\u6709\u975e\u9152\u7cbe\u6027\u8102\u80aa\u6027\u809d\u708e\u7684\u5927\u9f20\u53ef\u4ee5\u964d\u4f4eNAS\u548c\u809d\u810f\u7ea4\u7ef4\u5316\u8bc4\u5206\u3002\u76ee\u524d\u7684\u7597\u6548\u6570\u636e\u652f\u6301ASC41\u5f00\u5c55\u540e\u671f\u4e34\u5e8a\u8bd5\u9a8c\u3002<\/p>\n<p><b>3<\/b><b>\u3001\u6807\u9898\uff1a\u65b0\u578b\u975e\u753e\u4f53<\/b><b>FXR<\/b><b>\u6fc0\u52a8\u5242<\/b><b>ASC42<\/b><b>\u5bf9\u9ad8\u8102\u996e\u98df\u5bfc\u81f4\u7684\u60a3\u6709\u975e\u9152\u7cbe\u6027\u8102\u80aa\u6027\u809d\u708e\u5c0f\u9f20\u975e\u9152\u7cbe\u6027\u8102\u80aa\u6027\u6d3b\u52a8\u79ef\u5206\u548c\u809d\u7ea4\u7ef4\u5316\u8bc4\u5206\u7684\u663e\u8457\u6539\u5584<\/b><\/p>\n<p><b>\u6458\u8981<\/b><b>\/<\/b><b>\u6d77\u62a5\u7f16\u53f7<\/b>\uff1a1961<\/p>\n<p><b>\u7c7b\u522b<\/b>\uff1a\u975e\u9152\u7cbe\u6027\u8102\u80aa\u6027\u809d\u75c5\u6cbb\u7597<\/p>\n<p><b>\u7ed3\u679c<\/b>\uff1aASC42\u5bf9\u6539\u5584\u809d\u8102\u80aa\u53d8\u6027\u3001\u708e\u6027\u7ec6\u80de\u6d78\u6da6\u3001\u6c14\u7403\u6837\u53d8\u548c\u975e\u9152\u7cbe\u6027\u8102\u80aa\u809d\u6d3b\u52a8\u79ef\u5206\uff08NAS\uff09\u5448\u5242\u91cf\u4f9d\u8d56\u6027\u3002\u4e0e30 mg\/kg\u7684\u5965\u8d1d\u80c6\u9178\u76f8\u6bd4\uff0c30 mg\/kg\u7684ASC42\u663e\u793a\u51fa\u66f4\u9ad8\u7684NAS\u79ef\u5206\u964d\u4f4e\uff08<i>P<\/i>&lt;0.001\uff09\u3002ASC42\u57283mg\/kg\u65f6\u663e\u793aNAS\u79ef\u5206\u964d\u4f4e46.2%\uff0c\u809d\u7ea4\u7ef4\u5316\u964d\u4f4e15.2%\uff0c\u4e0e30mg\/kg\u5965\u8d1d\u80c6\u9178\u76f8\u5f53\u3002\u5728ASC42\u6cbb\u7597\u7684\u5c0f\u9f20\u4e2d\uff0c\u809d\u810f\u4e2d\u7684\u7518\u6cb9\u4e09\u916f\u5448\u5242\u91cf\u6bd4\u4f8b\u4e0b\u964d\u3002<\/p>\n<p><b><span id=\"spanHghltc3e2\">\u7ed3\u8bba\uff1a<\/span><\/b>ASC42\u5bf9\u9ad8\u8102\u996e\u98df\u5bfc\u81f4\u60a3\u6709\u975e\u9152\u7cbe\u6027\u8102\u80aa\u6027\u809d\u708e\u7684\u5c0f\u9f20\u53ef\u4ee5\u964d\u4f4eNAS\u79ef\u5206\u548c\u809d\u810f\u7ea4\u7ef4\u5316\u8bc4\u5206\u3002\u8fd9\u4e9b\u6570\u636e\u652f\u6301ASC42\u5f00\u5c55\u540e\u671f\u4e34\u5e8a\u8bd5\u9a8c\u3002<\/p>\n<p><b>4<\/b><b>\u3001\u6807\u9898\uff1a\u65b0\u578b\u975e\u753e\u4f53<\/b><b>FXR<\/b><b>\u6fc0\u52a8\u5242<\/b><b>ASC42<\/b><b>\u5bf9\u52a8\u7269\u4f53\u5185\u548c\u4f53\u5916<\/b><b>HBsAg<\/b><b>\u548c<\/b><b>HBV pgRNA<\/b><b>\u6709\u663e\u8457\u6291\u5236\u4f5c\u7528<\/b><\/p>\n<p><b>\u6458\u8981<\/b><b>\/<\/b><b>\u6d77\u62a5\u7f16\u53f7<\/b>\uff1a1917<\/p>\n<p><b>\u7c7b\u522b<\/b>\uff1a\u75c5\u6bd2\u6027\u809d\u708e<\/p>\n<p><b>\u7ed3\u679c<\/b>\uff1a\u5728\u539f\u4ee3\u4eba\u809d\u7ec6\u80de\uff08PHH\uff09\u6a21\u578b\u4e2d\uff0c\u5bf9\u7167\u5316\u5408\u7269\u6069\u66ff\u5361\u97e6\uff08ETV\uff09\u5bf9HBV DNA\u5177\u6709\u9884\u671f\u7684\u6291\u5236\u6d3b\u6027\uff0c\u4f46\u5bf9HBV pgRNA\u548cHBsAg\u65e0\u6291\u5236\u4f5c\u7528\uff0c\u800cASC42\u5bf9HBsAg\u3001HBV pgRNA\u548cHBV DNA\u5448\u5242\u91cf\u4f9d\u8d56\u6027\u6291\u5236\uff0cEC50\u5206\u522b\u4e3a0.79\u03bcM\u30010.09\u03bcM\u548c0.62\u03bcM\uff08\u56fe1 A-D\uff09\u3002\u5728AAV\/HBV\u5c0f\u9f20\u6a21\u578b\u4e2d\uff0cETV\uff080.1mg\/kg\uff09\u5355\u836f\u6cbb\u7597\u540e\uff0c\u5c0f\u9f20\u8840\u6d46HBV DNA\u660e\u663e\u4e0b\u964d\uff0cHBV pgRNA\u548cHBsAg\u65e0\u660e\u663e\u4e0b\u964d\uff0cASC42\u5bf9\u5c0f\u9f20\u8840\u6d46\u4e2dHBV pgRNA\u3001HBsAg\u3001HBV DNA\u5177\u6709\u5242\u91cf\u4f9d\u8d56\u6027\u6291\u5236\u4f5c\u7528\u3002\u4e0e\u6eb6\u5a92\u5bf9\u7167\u7ec4\u76f8\u6bd4\uff0cASC42\u9ad8\u5242\u91cf\u7ec4\uff0860 mg\/kg\uff09\u5206\u522b\u964d\u4f4eHBV pgRNA\u3001HBsAg\u548cHBV DNA 0.60 log10\u62f7\u8d1d\/\u03bcl\uff08<i>P<\/i>&nbsp;&lt;0.01\uff09\u30010.38 log10 IU\/\u03bcl\uff08<i>P<\/i>&nbsp;=0.002\uff09<span id=\"spanHghlt3414\">\u548c0.77 log10\u62f7\u8d1d\/\u03bcl\uff08<i>P<\/i>&nbsp;&lt;0.05\uff09\uff08\u56fe1 E-F\uff09\u3002<\/span>&nbsp; <\/p>\n<div class=\"PRN_ImbeddedAssetReference\" id=\"DivAssetPlaceHolder4738\">\n<p><a href=\"https:\/\/mma.prnasia.com\/media2\/1485141\/image1.html\" target=\"_blank\" rel=\"nofollow noopener\"><img decoding=\"async\" src=\"https:\/\/www.xinwengao.com\/cn\/wp-content\/uploads\/image1-520.jpg\" title=\"\" alt=\"\" \/><\/a><br \/><span><\/span><\/p>\n<\/p><\/div>\n<p><b>\u7ed3\u8bba<\/b>\uff1aFXR\u6fc0\u52a8\u5242ASC42\u5bf9HBV DNA\u3001HBV 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\u4e59\u809d\uff1a\u6b4c\u793c\u4e13\u6ce8\u4e8e\u4e59\u809d\u4e34\u5e8a\u6cbb\u6108\u521b\u65b0\u836f\u7269\u7684\u7814\u53d1\u3002\u63a2\u7d22\u4ee5\u76ae\u4e0b\u6ce8\u5c04PD-L1\u6297\u4f53ASC22\u53ca\u6d3e\u7f57\u6b23&reg;\u4e3a\u57fa\u77f3\u836f\u7269\uff0c\u4e0e\u5176\u4ed6\u9776\u70b9\u836f\u7269\u8054\u5408\u7684\u6cbb\u7597\u65b9\u6848\uff0c\u6709\u671b\u4e3a\u4e34\u5e8a\u6cbb\u6108\u4e59\u809d\u5e26\u6765\u91cd\u5927\u7a81\u7834\u3002(ii) \u4e19\u809d\uff1a\u6b4c\u793c\u6210\u529f\u7814\u53d1\u4e0a\u5e02\u4e24\u4e2a1\u7c7b\u65b0\u836f\u6208\u8bfa\u536b&reg;\u548c\u65b0\u529b\u83b1&reg;\uff0c\u7ec4\u6210\u5168\u53e3\u670d\u4e19\u809d\u6cbb\u7597\u65b9\u6848\uff1bASC18\u56fa\u5b9a\u5242\u91cf\u590d\u65b9\u5236\u5242\u662f\u5347\u7ea7\u7248\u7684\u4e19\u809d\u6cbb\u7597\u65b9\u6848\uff0c\u5df2\u5b8c\u6210\u6865\u63a5\u8bd5\u9a8c\u30024\u3001\u827e\u6ecb\u75c5\uff1aASC09F\u662f\u4e00\u79cd\u7528\u4e8e\u6cbb\u7597HIV\u7684\u86cb\u767d\u9176\u56fa\u5b9a\u5242\u91cf\u590d\u65b9\u6291\u5236\u5242\uff0cASC09F\u7684\u4e34\u5e8a\u8bd5\u9a8c\u7533\u8bf7\u5df2\u83b7\u5f97\u6279\u51c6\u3002\u6b32\u4e86\u89e3\u66f4\u591a\u4fe1\u606f\uff0c\u8bf7\u767b\u5f55\u7f51\u7ad9\uff1a<a target=\"_blank\" href=\"http:\/\/www.ascletis.com\/\" rel=\"nofollow noopener\">www.ascletis.com<\/a>\u3002<\/p>\n<div class=\"PRN_ImbeddedAssetReference\" id=\"DivAssetPlaceHolder0\">  <\/div>\n<p>\u76f8\u5173\u94fe\u63a5 :<\/p>\n<p>http:\/\/www.ascletis.com<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u4e2d\u56fd\u676d\u5dde\u548c\u7ecd\u51742021\u5e744\u670812\u65e5 \/\u7f8e\u901a\u793e\/ &#8212; \u6b4c\u793c\u5236\u836f\u6709\u9650\u516c\u53f8\uff08\u9999\u6e2f\u8054\u4ea4\u6240\u4ee3\u7801\uff1a1672\uff09\u4eca\u65e5\u5ba3\u5e03\uff0c\u516c\u53f8\u5728\u975e\u9152\u7cbe\u6027\u8102\u80aa\u6027\u809d\u708e\u548c\u4e59\u809d\u9886\u57df\u7684\u56db\u7bc7\u4e34\u5e8a\u548c\u4e34\u5e8a\u524d\u7814\u7a76\u6458\u8981\u5165\u90092021\u5e74\u6b27\u6d32\u809d\u810f\u7814\u7a76\u5b66\u4f1a\uff08EASL\uff09\u5e74\u4f1a\u66a8\u56fd\u9645\u809d\u75c5\u5927\u4f1a\uff08The International Liver Congress&#x2122; 2021, ILC 2021\uff09\u7684\u58c1\u62a5\u5c55\u793a\u3002\u4ee5\u4e0b\u4e3a4\u7bc7\u6458\u8981\u7684\u6982\u8981\u4fe1\u606f\uff1a 1\u3001\u6807\u9898\uff1a\u809d\u810f\u9776\u5411THR-\u03b2\u6fc0\u52a8\u5242ASC41\u53e3\u670d\u7247\u5177\u6709\u663e\u8457\u964d\u8102\u4f5c\u7528\uff1a\u4e00\u9879&nbsp;\u2160 \u671f\u968f\u673a\u3001\u53cc\u76f2\u3001\u5b89\u6170\u5242\u5bf9\u7167\u5355\u5242\u91cf\u548c\u591a\u5242\u91cf\u9012\u589e\u7814\u7a76 \u6458\u8981\/\u6d77\u62a5\u7f16\u53f7\uff1a1851 \u7c7b\u522b\uff1a\u975e\u9152\u7cbe\u6027\u8102\u80aa\u6027\u809d\u75c5\u6cbb\u7597 \u7ed3\u679c\uff1a\u5728\u5355\u5242\u91cf\u9012\u589e\u7684\u7814\u7a76\u4e2d\uff0c\u968f\u7740\u7ed9\u836f\u5242\u91cf\u4ece1 mg\u523020 mg\uff0cASC41\u7684\u836f\u4ee3\u52a8\u529b\u5b66\u7279\u5f81\u5448\u7ebf\u6027\u5173\u7cfb\uff0c\u4e14\u5728\u9ad8\u8fbe20 mg\u7684\u5242\u91cf\u7ec4\u4e2d\u4ecd\u8868\u73b0\u51fa\u826f\u597d\u7684\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\u3002\u5728\u591a\u5242\u91cf\u9012\u589e\u7684\u4e34\u5e8a\u7814\u7a76\u4e2d\uff0c\u7ecf\u8fc714\u5929\u6bcf\u65e5\u53e3\u670d\u4e00\u6b21ASC41\u7247\u5242\u6cbb\u7597\u540e\uff0c\u7ed9\u836f\u7ec4\u53d7\u8bd5\u8005\u7684\u4f4e\u5bc6\u5ea6\u8102\u86cb\u767d\u80c6\u56fa\u9187\uff08LDL-C\uff09\u548c\u7518\u6cb9\u4e09\u916f\uff08TG\uff09\u6307\u6807\u76f8\u5bf9\u5b89\u6170\u5242\u7ec4\u8868\u73b0\u51fa\u5177\u6709\u4e34\u5e8a\u610f\u4e49\u548c\u7edf\u8ba1\u5b66\u663e\u8457\u6027\u7684\u964d\u4f4e\uff0c\u5982\u4e0b\u8868\u6240\u793a\uff1a \u53bb\u9664\u5b89\u6170\u5242\u6548\u5e94\u540e\uff0c\u7ecf\u8fc714\u5929\u6bcf\u65e5\u53e3\u670d\u4e00\u6b21ASC41\u7247\u5242\u6cbb\u7597\u540e\u76f8\u5bf9\u57fa\u7ebf\u53d8\u5316\uff08\u5e73\u5747\u503c\uff09 1 mg (n=12) 2 mg (n=12) 5 mg (n=12) \u53bb\u9664\u5b89\u6170\u5242\u6548\u5e94\u540e\uff0c\u4f4e\u5bc6\u5ea6\u8102\u86cb\u767d\u80c6\u56fa\u9187\uff08LDL-C\uff09\u964d\u4f4e P\u503c&nbsp;vs \u5b89\u6170\u5242 -0.42% P=0.947 -11.94% P=0.052 -19.99% P=0.002 \u53bb\u9664\u5b89\u6170\u5242\u6548\u5e94\u540e\uff0c\u7518\u6cb9\u4e09\u916f\uff08TG\uff09\u964d\u4f4e P\u503c&nbsp;vs \u5b89\u6170\u5242 -39.43% P=0.002 -31.06% P=0.029 -34.49% P=0.015 \u572814\u5929\u6cbb\u7597\u4e2d\uff0cASC41\u5728\u6240\u6709\u5242\u91cf\u7ec4\u4e2d\u65e03\u7ea7\u6216\u4ee5\u4e0a\u4e0d\u826f\u4e8b\u4ef6\u3001\u4e25\u91cd\u4e0d\u826f\u4e8b\u4ef6\u6216\u63d0\u524d\u505c\u836f\u4e8b\u4ef6\u53d1\u751f\u3002\u572814\u5929\u6bcf\u65e5\u53e3\u670d\u4e00\u6b21ASC41\u7247\u5242\u7684\u7814\u7a76\u4e2d\uff0c\u968f\u7740\u7ed9\u836f\u5242\u91cf\u4ece1 mg\u589e\u52a0\u52305 mg\uff0cASC41\u7247\u5242\u7684\u836f\u4ee3\u52a8\u529b\u5b66\u7279\u5f81\u5448\u7ebf\u6027\u5173\u7cfb\u3002 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