{"id":24870,"date":"2021-03-30T19:26:00","date_gmt":"2021-03-30T12:26:00","guid":{"rendered":"https:\/\/www.xinwengao.com\/cn\/pr\/2021033019260024870"},"modified":"2021-03-30T21:39:56","modified_gmt":"2021-03-30T13:39:56","slug":"%e4%bf%a1%e8%be%be%e7%94%9f%e7%89%a9%e5%85%ac%e5%b8%832020%e5%b9%b4%e5%85%a8%e5%b9%b4%e4%b8%9a%e7%bb%a9%e5%8f%8a%e5%85%ac%e5%8f%b8%e8%bf%9b%e5%b1%95%ef%bc%9a%e4%b8%89%e4%b8%aa%e6%96%b0%e8%8d%af","status":"publish","type":"post","link":"https:\/\/www.xinwengao.com\/cn\/pr\/2021033019260024870","title":{"rendered":"\u4fe1\u8fbe\u751f\u7269\u516c\u5e032020\u5e74\u5168\u5e74\u4e1a\u7ee9\u53ca\u516c\u53f8\u8fdb\u5c55\uff1a\u4e09\u4e2a\u65b0\u836f\u4e0a\u5e02\uff0c\u56db\u6b3e\u4ea7\u54c1\u5546\u4e1a\u5316\uff0c\u603b\u6536\u516538.4\u4ebf\u5143"},"content":{"rendered":"<p><p>\u7f8e\u56fd\u65e7\u91d1\u5c71\u548c\u4e2d\u56fd\u82cf\u5dde2021\u5e743\u670830\u65e5 \/\u7f8e\u901a\u793e\/ &#8212; 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id=\"spanHghlte96e\">\u3002\u524d<\/span>\u4e5d\u5e74\uff0c\u4fe1\u8fbe\u751f\u7269\u5df2\u7ecf\u6210\u957f\u4e3a\u4e00\u5bb6\u6db5\u76d6\u7814\u53d1\u3001CMC\u3001\u5546\u4e1a\u5316\u7684\u7efc\u5408\u6027\u751f\u7269\u5236\u836f\u4f01\u4e1a\u30022021\u5e74\u662f\u4fe1\u8fbe\u6210\u7acb\u7684\u7b2c\u5341\u5e74\uff0c\u4e0b\u4e00\u4e2a\u5341\u5e74\uff0c\u5168\u7403\u521b\u65b0\u548c\u4e1a\u52a1\u5168\u7403\u5316\u5c06\u662f\u516c\u53f8\u6700\u4e3b\u8981\u7684\u6218\u7565\u65b9\u5411\u3002\u6211\u4eec\u6b63\u52a0\u901f\u56fd\u9645\u5316\u4eba\u624d\u62db\u52df\u3001\u6253\u9020\u5177\u6709\u5168\u7403first-in-class\u521b\u65b0\u80fd\u529b\u7684\u7814\u53d1\u5e73\u53f0\u5e76\u52a0\u901f\u7ba1\u7ebf\u7684\u5168\u7403\u5f00\u53d1\u3002\u6211\u4eec\u5c06\u81f4\u529b\u4e8e\u6210\u957f\u4e3a\u5177\u6709\u9ad8\u5ea6\u7ade\u4e89\u529b\u548c\u66f4\u9ad8\u6f5c\u529b\u7684\u5168\u7403\u4e00\u6d41\u751f\u7269\u5236\u836f\u516c\u53f8\uff0c\u4e3a\u60a3\u8005\u3001\u5458\u5de5\u3001\u80a1\u4e1c\u548c\u793e\u4f1a\u4e0d\u65ad\u521b\u9020\u4ef7\u503c\uff0c\u5e76\u5b9e\u73b0\u516c\u53f8\u7684\u957f\u671f\u53ef\u6301\u7eed\u53d1\u5c55\u3002\u201d<\/p>\n<p><b>\u4e1a\u52a1\u6458\u8981\uff08<\/b><b>2020<\/b><b>\u5e74\u53ca<\/b><b>2021<\/b><b>\u5e74\u81f3\u4eca\uff09<\/b><\/p>\n<p><b>\u4e09\u4e2a\u65b0\u836f\u4e0a\u5e02\uff0c\u56db\u6b3e\u5546\u4e1a\u5316\u4ea7\u54c1\uff0c2020\u5e74\u4ea7\u54c1\u6536\u5165\u8fbe23.7\u4ebf\u5143<\/b><\/p>\n<ul type=\"disc\">\n<li>\u7ee7\u8fbe\u4f2f\u8212<sup>&reg;<\/sup>\u4e8e2018\u5e7412\u6708\u6b63\u5f0f\u83b7\u6279\u540e\uff0c2020\u5e74\u516c\u53f8\u8fce\u6765\u4e09\u6b3e\u65b0\u836f\u4ea7\u54c1\u7684\u83b7\u6279\u4e0a\u5e02\u3002\u8fbe\u6538\u540c<sup>&reg;<\/sup>\u3001\u82cf\u7acb\u4fe1<sup>&reg;<\/sup>\u548c\u8fbe\u4f2f\u534e<sup>&reg;<\/sup>\u4e8e2020\u5e74\u6b63\u5f0f\u83b7\u5f97NMPA\u6279\u51c6\u4e0a\u5e02\uff0c\u4f7f\u5f97\u4fe1\u8fbe\u751f\u7269\u6210\u4e3a\u552f\u4e00\u4e00\u4e2a\u5728\u6210\u7acb\u4e5d\u5e74\u5185\u5c31\u6709\u56db\u6b3e\u6297\u4f53\u751f\u7269\u836f\u5728\u4e2d\u56fd\u4e0a\u5e02\u7684\u751f\u7269\u5236\u836f\u516c\u53f8\u3002 <\/li>\n<li>2020\u5e74\u4f5c\u4e3a\u516c\u53f8\u6b63\u5f0f\u5b9e\u73b0\u5546\u4e1a\u5316\u7684\u7b2c\u4e8c\u5e74\uff0c\u5b9e\u73b0\u4ea7\u54c1\u6536\u5165\u4eba\u6c11\u5e0123.7\u4ebf\u5143\u3002 <\/li>\n<li>2020\u5e74\uff0c\u8fbe\u4f2f\u8212<sup>&reg;<\/sup>\u4f5c\u4e3a\u552f\u4e00\u4e00\u6b3e\u8fdb\u5165\u56fd\u5bb6\u533b\u4fdd\u76ee\u5f55\u7684\u9ad8\u8d28\u91cfPD-1\u6291\u5236\u5242\uff0c\u5b9e\u73b0\u4eba\u6c11\u5e0122.9\u4ebf\u5143\u7684\u4ea7\u54c1\u6536\u5165\uff0c\u8f832019\u5e74\u589e\u957f125.4%\u3002\u6b64\u5916\uff0c2021\u5e742\u6708\uff0c\u8fbe\u4f2f\u8212<sup>&reg;<\/sup>\u83b7\u6279\u8054\u5408\u5316\u7597\u6cbb\u7597\u4e00\u7ebf\u975e\u9cde\u72b6\u975e\u5c0f\u7ec6\u80de\u80ba\u764c&nbsp;(NSCLC)\uff0c\u53d6\u5f97\u7ee7\u970d\u5947\u91d1\u6dcb\u5df4\u7624\u540e\u7684\u7b2c\u4e8c\u9879\u9002\u5e94\u75c7\u3002\u8fbe\u4f2f\u8212<sup>&reg;<\/sup>\u53e6\u6709\u4e09\u9879NDA\u7533\u8bf7\u5df2\u83b7\u53d7\u7406\u5e76\u5728NMPA\u5ba1\u8bc4\u4e2d\uff0c\u9884\u8ba1\u5c06\u4e8e2021\u5e74\u81f32022\u5e74\u521d\u9646\u7eed\u83b7\u6279\uff0c\u5305\u62ec1\uff09\u8054\u5408\u5316\u7597\u6cbb\u7597\u4e00\u7ebf\u9cde\u72b6NSCLC<span id=\"spanHghlt3f7f\">\uff1b<\/span>2) \u8054\u5408\u8fbe\u6538\u540c\u6cbb\u7597\u4e00\u7ebf\u809d\u7ec6\u80de\u764c\uff08HCC\uff09\uff1b3\uff09\u6cbb\u7597\u4e8c\u7ebf\u9cde\u72b6NSCLC \u3002<\/li>\n<\/ul>\n<p><b>\u5df2\u5efa\u7acb\u4e00\u6761\u62e5\u670923\u4e2a\u9ad8\u4ef7\u503c\u4e34\u5e8a\u4ea7\u54c1\u7684\u7ba1\u7ebf<\/b><\/p>\n<p>\u516c\u53f8\u6b63\u5728\u5168\u7403\u5f00\u53d123\u4e2a\u9ad8\u4ef7\u503c\u7684\u4e34\u5e8a\u7ba1\u7ebf\uff0c\u5176\u4e2d4\u6b3e\u83b7\u6279\u4e0a\u5e02\u30015\u6b3e\u5904\u4e8e\u6ce8\u518c\u6216\u5173\u952e\u4e34\u5e8a\u9636\u6bb5\u300114\u6b3e\u5904\u4e8e\u4e34\u5e8a\u4e00\u671f\u6216\u4e8c\u671f\u4e0d\u540c\u9636\u6bb5\u300223\u6b3e\u4ea7\u54c1\u6db5\u76d6\u5355\u514b\u9686\u6297\u4f53\u3001\u53cc\u6297\u3001\u5c0f\u5206\u5b50\u3001\u7ec6\u80de\u6cbb\u7597\u7b49\u9886\u57df\u3002\u5176\u4e2d\uff0c\u516c\u53f8IO\u7ba1\u7ebf\u5e03\u5c40\u5168\u9762\u4e14\u9ad8\u5ea6\u5dee\u5f02\u5316\u3001\u53cc\u6297\u7ba1\u7ebf\u4e1a\u5185\u9886\u5148\u3001\u975e\u80bf\u7624\u7ba1\u7ebf\u72ec\u5177\u7279\u8272\uff0c\u8574\u542b\u5de8\u5927\u7684\u6f5c\u5728\u4ef7\u503c\u3002<\/p>\n<p><b>\u4e94\u6b3e\u4ea7\u54c1\u7ba1\u7ebf\u5904\u4e8e\u6ce8\u518c\u6216\u5173\u952e\u4e34\u5e8a\u9636\u6bb5<\/b><\/p>\n<p>\u9664\u56db\u6b3e\u5df2\u4e0a\u5e02\u4ea7\u54c1\u5916\uff0c2020\u5e74\u516c\u53f8\u53e6\u6709\u4e94\u6b3e\u4ea7\u54c1\u5904\u4e8e\u6ce8\u518c\u6216\u5173\u952e\u4e34\u5e8a\u9636\u6bb5\uff0c\u9884\u671f\u5c06\u4e8e\u672a\u6765\u51e0\u5e74\u5185\u9646\u7eed\u4e0a\u5e02\uff0c\u5305\u62ec\uff1a<\/p>\n<ul type=\"disc\">\n<li>IBI-310 \uff08CTLA-4\u5355\u6297\uff09 <\/li>\n<li>IBI-375 (FGFR TKI) <\/li>\n<li>IBI-376 (PI3K<span id=\"spanHghltf2b0\">\u03b4<\/span>&nbsp;TKI) <\/li>\n<li>IBI-306 \uff08PCSK9\u5355\u6297\uff09 <\/li>\n<li>IBI-326 (BCMA CAR-T)<\/li>\n<\/ul>\n<p><b>\u80bf\u7624\u7ba1\u7ebf\u5168\u9762\u5e03\u5c40\uff0c\u591a\u6b3e\u9ad8\u6f5c\u529bIO\u9776\u70b9\u8fdb\u5c55\u9886\u5148<\/b><\/p>\n<p>\u9664\u62f3\u5934\u4ea7\u54c1PD-1\u6291\u5236\u5242\u8fbe\u4f2f\u8212<sup>&reg;<\/sup>\u5916\uff0c2020\u5e74\u591a\u6b3e\u9ad8\u6f5c\u529b\u80bf\u7624\u514d\u75ab\u7ba1\u7ebf\u8fdb\u5c55\u8fc5\u901f\uff1a<\/p>\n<ul type=\"disc\">\n<li>CD47\u9886\u57df\uff1a\u516c\u53f8\u5e03\u5c40\u4e09\u6b3e\u5dee\u5f02\u5316\u54c1\u79cd\uff0c\u5176\u4e2dIBI-188\u4e3a\u6f5c\u5728\u540c\u7c7b\u6700\u4f73&nbsp;(best-in-class)\u7684CD47\u5355\u6297, 2020\u5e74\u5b8c\u6210\u4e2d\u7f8e1a\u671f\u5242\u91cf\u63a2\u7d22\uff0c\u5e76\u5f00\u59cb\u8fdb\u884c1b\u671f\u7684\u4e34\u5e8a\u8bd5\u9a8c\uff0c2021\u5e74\u8ba1\u5212\u8fdb\u5165\u4e09\u671f\u6216\u5173\u952e\u4e34\u5e8a\uff1bIBI-322\u4e3a\u6f5c\u5728\u540c\u7c7b\u9996\u521b&nbsp;(first-in-class) \u7684PD-L1\/CD47\u53cc\u6297\uff0c\u76ee\u524d\u5df2\u5728\u4e2d\u56fd\u548c\u7f8e\u56fd\u5f00\u5c55\u4e34\u5e8a1\u671f\u8bd5\u9a8c\uff0c2021\u5e74\u8ba1\u5212\u53d6\u5f97PoC \uff08\u6982\u5ff5\u9a8c\u8bc1\u6570\u636e\uff09\uff1b\u516c\u53f8\u53e6\u6709\u540c\u901a\u8def\u7684\u6f5c\u5728\u540c\u7c7b\u6700\u4f73&nbsp;&nbsp;(best-in-class) SIRPa\u5355\u6297\u5904\u4e8e\u4e34\u5e8a\u524d\u7814\u7a76\u9636\u6bb5\u3002 <\/li>\n<li>LAG-3\u9886\u57df<span id=\"spanHghlt3147\">\uff1a<\/span>IBI-110\u4e3a\u56fd\u5185\u9996\u4e2a\u83b7\u6279IND\u7684LAG-3\u5355\u6297\uff0c\u5df2\u5b8c\u62101b\u671f\u4e34\u5e8a\u5165\u7ec4\uff0c\u8ba1\u52122021\u5e74\u53d6\u5f97PoC\uff1b\u6f5c\u5728\u540c\u7c7b\u9996\u521b&nbsp;(first-in-class) PD-L1\/LAG-3\u53cc\u6297\u5df2\u83b7\u5f97IND\u6279\u4ef6\uff0c\u8ba1\u52122021\u5f00\u5c551\u671f\u4e34\u5e8a\u3002 <\/li>\n<li>TIGIT\u9886\u57df<span id=\"spanHghlt3147\">\uff1a<\/span>\u516c\u53f8TIGIT\u5355\u6297\u7814\u53d1\u8fdb\u5ea6\u9886\u5148\uff0cIBI-939\u5df2\u8fdb\u5165\u4e34\u5e8a1b\u9636\u6bb5\uff0c\u8ba1\u52122021\u5e74\u53d6\u5f97PoC\u3002\u53e6\u6709PD-1\/TIGIT\u53cc\u6297IBI-321\u5df2\u7533\u62a5\u4e34\u5e8a\uff0c\u8ba1\u52122021\u5e74\u5f00\u5c55\u4e34\u5e8a\u3002 <\/li>\n<li>IBI-318<span id=\"spanHghlt0501\">\uff08<\/span>PD1\/PDL1\u53cc\u6297<span id=\"spanHghltb168\">\uff09\uff1a<\/span>\u5df2\u5b8c\u62101a\u671f\u5242\u91cf\u63a2\u7d22\uff0c\u5e76\u4e8e2020\u5e74\u4e0b\u534a\u5e74\u8fdb\u5165\u591a\u98791b\u671f\u8bd5\u9a8c\u4ee5\u63a2\u7d22IBI-318\u5728\u4e0d\u540c\u764c\u75c7\u9002\u5e94\u75c7\u7684\u6f5c\u529b\u3002<\/li>\n<\/ul>\n<p><b>\u72ec\u5177\u7279\u8272\u7684\u975e\u80bf\u7624\u7ba1\u7ebf<\/b><\/p>\n<p>\u975e\u80bf\u7624\u7ba1\u7ebf\u72ec\u5177\u7279\u8272\uff0c\u6db5\u76d6\u81ea\u514d\u3001\u65b0\u9648\u4ee3\u8c22\u3001\u5fc3\u8840\u7ba1\u548c\u773c\u79d1\u30022020\u5e74\u975e\u80bf\u7624\u7ba1\u7ebf\u6301\u7eed\u53d6\u5f97\u8fdb\u5c55\uff0c\u7279\u522b\u662f\uff1a&nbsp;<\/p>\n<ul type=\"disc\">\n<li>IBI-362 (OXM3)<span id=\"spanHghlt3147\">\uff1a<\/span>\u5df2\u8fdb\u884c\u7528\u4e8e\u6cbb\u7597\u80a5\u80d6\u53d7\u8bd5\u8005\u53ca\u7cd6\u5c3f\u75c5\u60a3\u8005\u76841b\u671f\u7814\u7a76\uff0c\u663e\u793a\u51fa\u4f18\u79c0\u7684\u964d\u7cd6\u51cf\u91cd\u6548\u679c\uff1b\u8ba1\u5212\u4e8e2021\u5e74\u5f00\u5c552\u671f\u4e34\u5e8a\u7814\u7a76\u3002 <\/li>\n<li>IBI-302\uff08VEGF\u2571\u8865\u4f53\u86cb\u767d\uff09<span id=\"spanHghlt3147\">\uff1a<\/span>1\u671f\u7814\u7a76\u7528\u4e8e\u6cbb\u7597\u6e7f\u6027\u5e74\u9f84\u76f8\u5173\u9ec4\u6591\u53d8\u6027\uff08\u300c\u6e7f\u6027AMD\u300d\uff09\u7684\u521d\u6b65\u6570\u636e\u4e50\u89c2\uff1b\u8ba1\u5212\u4e8e2021\u5e74\u5f00\u5c552\u671f\u4e34\u5e8a\u7814\u7a76\u3002<\/li>\n<\/ul>\n<p><b>\u8fbe\u6210\u591a\u9879\u6d77\u5185\u5916\u6218\u7565\u5408\u4f5c<\/b><\/p>\n<p>2020\u5e74\u53ca2021\u5e74\u81f3\u4eca\u516c\u53f8\u4e0e\u56fd\u5185\u5916\u5408\u4f5c\u4f19\u4f34\u8fbe\u6210\u4e00\u7cfb\u5217\u6218\u7565\u5408\u4f5c\uff0c\u5176\u4e2d\uff1a<\/p>\n<ul type=\"disc\">\n<li>2020\u5e748\u6708\u4e0e\u793c\u6765\u5c31\u8fbe\u4f2f\u8212<sup>&reg;<\/sup>\u5728\u4e2d\u56fd\u5883\u5916\u7684\u72ec\u5bb6\u6743\u5229\u8ba2\u7acb\u7684\u6218\u7565\u6269\u5f20\u6388\u6743\u534f\u8bae\uff0c\u662f\u5c06\u516c\u53f8\u521b\u65b0\u4ea7\u54c1\u6218\u7565\u5f15\u5165\u56fd\u9645\u5e02\u573a\u7684\u91cc\u7a0b\u7891\u3002 <\/li>\n<li>\u6b64\u5916\uff0c\u516c\u53f8\u4e0e\u7f57\u6c0f\u5408\u4f5c\u4ee5\u63a2\u7d22\u53ca\u5f00\u53d1\u53cc\u7279\u5f02\u6027\u6297\u4f53\u53ca\u591a\u4e2a\u7ec6\u80de\u6cbb\u7597\u4ea7\u54c1\uff0c\u663e\u793a\u5168\u7403<span id=\"spanHghltb066\">\u9876\u7ea7<\/span>\u5236\u836f\u516c\u53f8\u5bf9\u6211\u4eec\u836f\u7269\u63a2\u7d22\u65b0\u836f\u53d1\u73b0\u548c\u7814\u53d1\u80fd\u529b\u7684\u8ba4\u53ef\uff0c\u5e76\u53ef\u8fdb\u4e00\u6b65\u4e8e\u7814\u53d1\u8fc7\u7a0b\u4e2d\u4e30\u5bcc\u6211\u4eec\u7684\u6f5c\u5728\u540c\u7c7b\u9996\u521b\u5728\u7814\u4ea7\u54c1\u3002<\/li>\n<\/ul>\n<p><b>\u6301\u7eed\u5f15\u5165\u5168\u7403\u4eba\u624d\uff0c\u7814\u53d1\u5347\u7ea7\u52a9\u529b\u5168\u7403\u521b\u65b0<\/b><\/p>\n<ul type=\"disc\">\n<li>\u516c\u53f8\u56e2\u961f\u75312019\u5e74\u5e95\u7684\u7ea62,000\u540d\u96c7\u5458\u6269\u589e\u81f32020\u5e74\u5e95\u76843,200\u540d\u96c7\u5458\u3002 <\/li>\n<li>\u516c\u53f8\u4efb\u547d\u751f\u7269\u5236\u836f\u884c\u4e1a\u7684\u4e16\u754c\u8457\u540d\u79d1\u5b66\u5bb6\u53ca\u4e1a\u5185\u9886\u5bfc\u8005\u5218\u52c7\u519b\u535a\u58eb\u4e3a\u603b\u88c1\uff0c\u8d1f\u8d23\u5168\u7403\u7814\u53d1\u3001\u7ba1\u7ebf\u6218\u7565\u3001\u4e1a\u52a1\u53d1\u5c55\u53ca\u56fd\u9645\u4e1a\u52a1\u3002 <\/li>\n<li>\u4e3a\u5b9e\u73b0\u516c\u53f8\u8d70\u5411\u5168\u7403\u521b\u65b0\u7684\u6218\u7565\u6027\u76ee\u6807\uff0c\u516c\u53f8\u5347\u7ea7\u7814\u53d1\u7ec4\u7ec7\u67b6\u6784\u3001\u660e\u786e\u5168\u7403\u521b\u65b0\u76ee\u6807\u548c\u62db\u52df\u5168\u7403\u7814\u53d1\u4eba\u624d\u3002<\/li>\n<\/ul>\n<p><b>\u4ea7\u80fd\u5927\u5e45\u6269\u5f20&nbsp;<\/b><\/p>\n<ul type=\"disc\">\n<li>2020\u5e74\u516c\u53f8\u603b\u4ea7\u80fd\u75315,000\u5347\u6210\u529f\u6269\u5c55\u81f324,000\u5347\uff0c\u4ee5\u6ee1\u8db3\u5728\u7814\u4ea7\u54c1\u4e2d\u5546\u4e1a\u5316\u4ea7\u54c1\u53ca\u4e34\u5e8a\u9636\u6bb5\u5019\u9009\u836f\u7269\u7684\u751f\u4ea7\u9700\u6c42\u300224,000\u5347\u7684\u4ea7\u80fd\u5305\u62ec\u8bbe\u6709\u516d\u59571,000\u5347\u4e00\u6b21\u6027\u53cd\u5e94\u5668\u7684\u7b2c\u4e00\u751f\u4ea7\u8bbe\u65bd\uff08M1a\uff09\uff0c\u53ca\u8bbe\u6709\u516d\u59573,000\u5347\u4e0d\u9508\u94a2\u751f\u7269\u53cd\u5e94\u5668\u7684\u7b2c\u4e8c\u751f\u4ea7\u8bbe\u65bd\uff08M1b\uff09\u3002 <\/li>\n<li>\u65b0\u7684\u751f\u4ea7\u8bbe\u65bd\uff08M2\u57fa\u5730\uff09\u4e5f\u5728\u5efa\u8bbe\u4e2d\uff0c\u8ba1\u5212\u914d\u5907\u5341\u4e8c\u59573,000\u5347\u7684\u4e0d\u9508\u94a2\u751f\u7269\u53cd\u5e94\u5668\uff0c\u4e8e\u7ae3\u5de5\u540e\uff0c\u516c\u53f8\u603b\u4ea7\u80fd\u5c06\u6269\u589e\u81f360,000\u5347\u3002<\/li>\n<\/ul>\n<p><b>\u8d44\u672c\u5e02\u573a\u6210\u7ee9\u6590\u7136<\/b><\/p>\n<ul type=\"disc\">\n<li>2020\u5e74\uff0c\u6807\u8bb0&nbsp;\u201cB<span id=\"spanHghlt2315\">\u201d<\/span>\u6210\u529f\u81ea\u516c\u53f8\u80a1\u4efd\u540d\u79f0\u6458\u9664\u3002 <\/li>\n<li>\u516c\u53f8\u80a1\u7968\u6210\u529f\u83b7\u7eb3\u5165\u6052\u751f\u7efc\u5408\u6307\u6570\u4ee5\u53ca\u6e2f\u80a1\u901a&nbsp;\u3002 <\/li>\n<li>\u4e8e2020\u5e74\u81f3\u4eca\uff0c\u516c\u53f8\u901a\u8fc7\u4e09\u8f6e\u65b0\u80a1\u516c\u5f00\u914d\u552e\u6210\u529f\u52df\u96c6\u5408\u5171\u7ea6&nbsp;98\u4ebf\u6e2f\u5143\uff08\u621613\u4ebf\u7f8e\u5143\uff09\u8d44\u91d1\uff0c\u83b7\u5f97\u56fd\u9645\u53ca\u5730\u533a\u7684\u77e5\u540d\u6295\u8d44\u8005\u5f3a\u52b2\u7684\u8ba4\u8d2d\u652f\u6301\u3002 <\/li>\n<li>\u622a\u81f3\u6700\u65b0\uff0c\u516c\u53f8\u62e5\u6709\u73b0\u91d1\u7ea618\u4ebf\u7f8e\u5143\uff0c\u4e3a\u6211\u4eec\u7684\u836f\u7269\u7814\u53d1\u3001\u6f5c\u5728\u4e1a\u52a1\u5408\u4f5c\u3001\u751f\u4ea7\u8bbe\u65bd\u6269\u5c55\u4ee5\u53ca\u4e0d\u65ad\u589e\u52a0\u7684\u56fd\u9645\u8425\u8fd0\u9700\u6c42\u63d0\u4f9b\u4e86\u5f3a\u5927\u7684\u652f\u6301\u3002<\/li>\n<\/ul>\n<p><b>\u8d22\u52a1\u6458\u8981\uff08<\/b><b>2020<\/b><b>\u8d22\u5e74\uff09<\/b><\/p>\n<ul type=\"disc\">\n<li>\u5b9e\u73b0\u603b\u6536\u5165\u4eba\u6c11\u5e0138.4\u4ebf\u5143\uff0c\u540c\u6bd4\u589e\u957f266.9%\u3002\u4e3b\u8981\u662f\u4ea7\u54c1\u6536\u5165\u8f83\u540c\u671f\u5f3a\u52b2\u589e\u957f\u548c\u62a5\u544a\u671f\u5185\u83b7\u5f97\u6388\u6743\u8d39\u53ca\u670d\u52a1\u6536\u5165\u589e\u52a0\u6240\u5f97\u3002 <\/li>\n<li>\u5b9e\u73b0\u4ea7\u54c1\u6536\u5165\u4eba\u6c11\u5e0123.7\u4ebf\u5143\uff0c\u540c\u6bd4\u589e\u957f133.0%\u3002\u4e3b\u8981\u662f\u62f3\u5934\u4ea7\u54c1\u8fbe\u4f2f\u8212\u540c\u6bd4\u5f3a\u52b2\u589e\u957f\u53ca\u4e09\u9879\u65b0\u83b7\u6279\u7684\u6297\u4f53\u836f\u7269\u4e8e2020\u5e74\u4e0b\u534a\u5e74\u6240\u8d21\u732e\u7684\u6536\u5165\u6240\u5f97\u3002 <\/li>\n<li>\u7814\u53d1\u6295\u5165\u4eba\u6c11\u5e0118.5\u4ebf\u5143\uff0c\u540c\u6bd4\u589e\u957f43.0%\u3002\u516c\u53f8\u7684\u7814\u53d1\u6295\u5165\u4e3b\u8981\u7528\u4e8e\u540e\u671f\u5f00\u53d1\u9636\u6bb5\u7ba1\u7ebf\u4ea7\u54c1\u7684\u5f00\u53d1\u548c\u4f18\u5148\u5728\u7814\u4ea7\u54c1\u7684\u5168\u7403\u5f00\u53d1\u3002 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2020\u5e74\uff0c\u8fbe\u4f2f\u8212&reg;\u4f5c\u4e3a\u552f\u4e00\u4e00\u6b3e\u8fdb\u5165\u56fd\u5bb6\u533b\u4fdd\u76ee\u5f55\u7684\u9ad8\u8d28\u91cfPD-1\u6291\u5236\u5242\uff0c\u5b9e\u73b0\u4eba\u6c11\u5e0122.9\u4ebf\u5143\u7684\u4ea7\u54c1\u6536\u5165\uff0c\u8f832019\u5e74\u589e\u957f125.4%\u3002\u6b64\u5916\uff0c2021\u5e742\u6708\uff0c\u8fbe\u4f2f\u8212&reg;\u83b7\u6279\u8054\u5408\u5316\u7597\u6cbb\u7597\u4e00\u7ebf\u975e\u9cde\u72b6\u975e\u5c0f\u7ec6\u80de\u80ba\u764c&nbsp;(NSCLC)\uff0c\u53d6\u5f97\u7ee7\u970d\u5947\u91d1\u6dcb\u5df4\u7624\u540e\u7684\u7b2c\u4e8c\u9879\u9002\u5e94\u75c7\u3002\u8fbe\u4f2f\u8212&reg;\u53e6\u6709\u4e09\u9879NDA\u7533\u8bf7\u5df2\u83b7\u53d7\u7406\u5e76\u5728NMPA\u5ba1\u8bc4\u4e2d\uff0c\u9884\u8ba1\u5c06\u4e8e2021\u5e74\u81f32022\u5e74\u521d\u9646\u7eed\u83b7\u6279\uff0c\u5305\u62ec1\uff09\u8054\u5408\u5316\u7597\u6cbb\u7597\u4e00\u7ebf\u9cde\u72b6NSCLC\uff1b2) \u8054\u5408\u8fbe\u6538\u540c\u6cbb\u7597\u4e00\u7ebf\u809d\u7ec6\u80de\u764c\uff08HCC\uff09\uff1b3\uff09\u6cbb\u7597\u4e8c\u7ebf\u9cde\u72b6NSCLC \u3002 \u5df2\u5efa\u7acb\u4e00\u6761\u62e5\u670923\u4e2a\u9ad8\u4ef7\u503c\u4e34\u5e8a\u4ea7\u54c1\u7684\u7ba1\u7ebf \u516c\u53f8\u6b63\u5728\u5168\u7403\u5f00\u53d123\u4e2a\u9ad8\u4ef7\u503c\u7684\u4e34\u5e8a\u7ba1\u7ebf\uff0c\u5176\u4e2d4\u6b3e\u83b7\u6279\u4e0a\u5e02\u30015\u6b3e\u5904\u4e8e\u6ce8\u518c\u6216\u5173\u952e\u4e34\u5e8a\u9636\u6bb5\u300114\u6b3e\u5904\u4e8e\u4e34\u5e8a\u4e00\u671f\u6216\u4e8c\u671f\u4e0d\u540c\u9636\u6bb5\u300223\u6b3e\u4ea7\u54c1\u6db5\u76d6\u5355\u514b\u9686\u6297\u4f53\u3001\u53cc\u6297\u3001\u5c0f\u5206\u5b50\u3001\u7ec6\u80de\u6cbb\u7597\u7b49\u9886\u57df\u3002\u5176\u4e2d\uff0c\u516c\u53f8IO\u7ba1\u7ebf\u5e03\u5c40\u5168\u9762\u4e14\u9ad8\u5ea6\u5dee\u5f02\u5316\u3001\u53cc\u6297\u7ba1\u7ebf\u4e1a\u5185\u9886\u5148\u3001\u975e\u80bf\u7624\u7ba1\u7ebf\u72ec\u5177\u7279\u8272\uff0c\u8574\u542b\u5de8\u5927\u7684\u6f5c\u5728\u4ef7\u503c\u3002 \u4e94\u6b3e\u4ea7\u54c1\u7ba1\u7ebf\u5904\u4e8e\u6ce8\u518c\u6216\u5173\u952e\u4e34\u5e8a\u9636\u6bb5 \u9664\u56db\u6b3e\u5df2\u4e0a\u5e02\u4ea7\u54c1\u5916\uff0c2020\u5e74\u516c\u53f8\u53e6\u6709\u4e94\u6b3e\u4ea7\u54c1\u5904\u4e8e\u6ce8\u518c\u6216\u5173\u952e\u4e34\u5e8a\u9636\u6bb5\uff0c\u9884\u671f\u5c06\u4e8e\u672a\u6765\u51e0\u5e74\u5185\u9646\u7eed\u4e0a\u5e02\uff0c\u5305\u62ec\uff1a IBI-310 \uff08CTLA-4\u5355\u6297\uff09 IBI-375 (FGFR TKI) IBI-376 (PI3K\u03b4&nbsp;TKI) IBI-306 \uff08PCSK9\u5355\u6297\uff09 IBI-326 (BCMA CAR-T) \u80bf\u7624\u7ba1\u7ebf\u5168\u9762\u5e03\u5c40\uff0c\u591a\u6b3e\u9ad8\u6f5c\u529bIO\u9776\u70b9\u8fdb\u5c55\u9886\u5148 \u9664\u62f3\u5934\u4ea7\u54c1PD-1\u6291\u5236\u5242\u8fbe\u4f2f\u8212&reg;\u5916\uff0c2020\u5e74\u591a\u6b3e\u9ad8\u6f5c\u529b\u80bf\u7624\u514d\u75ab\u7ba1\u7ebf\u8fdb\u5c55\u8fc5\u901f\uff1a CD47\u9886\u57df\uff1a\u516c\u53f8\u5e03\u5c40\u4e09\u6b3e\u5dee\u5f02\u5316\u54c1\u79cd\uff0c\u5176\u4e2dIBI-188\u4e3a\u6f5c\u5728\u540c\u7c7b\u6700\u4f73&nbsp;(best-in-class)\u7684CD47\u5355\u6297, 2020\u5e74\u5b8c\u6210\u4e2d\u7f8e1a\u671f\u5242\u91cf\u63a2\u7d22\uff0c\u5e76\u5f00\u59cb\u8fdb\u884c1b\u671f\u7684\u4e34\u5e8a\u8bd5\u9a8c\uff0c2021\u5e74\u8ba1\u5212\u8fdb\u5165\u4e09\u671f\u6216\u5173\u952e\u4e34\u5e8a\uff1bIBI-322\u4e3a\u6f5c\u5728\u540c\u7c7b\u9996\u521b&nbsp;(first-in-class) \u7684PD-L1\/CD47\u53cc\u6297\uff0c\u76ee\u524d\u5df2\u5728\u4e2d\u56fd\u548c\u7f8e\u56fd\u5f00\u5c55\u4e34\u5e8a1\u671f\u8bd5\u9a8c\uff0c2021\u5e74\u8ba1\u5212\u53d6\u5f97PoC \uff08\u6982\u5ff5\u9a8c\u8bc1\u6570\u636e\uff09\uff1b\u516c\u53f8\u53e6\u6709\u540c\u901a\u8def\u7684\u6f5c\u5728\u540c\u7c7b\u6700\u4f73&nbsp;&nbsp;(best-in-class) SIRPa\u5355\u6297\u5904\u4e8e\u4e34\u5e8a\u524d\u7814\u7a76\u9636\u6bb5\u3002 LAG-3\u9886\u57df\uff1aIBI-110\u4e3a\u56fd\u5185\u9996\u4e2a\u83b7\u6279IND\u7684LAG-3\u5355\u6297\uff0c\u5df2\u5b8c\u62101b\u671f\u4e34\u5e8a\u5165\u7ec4\uff0c\u8ba1\u52122021\u5e74\u53d6\u5f97PoC\uff1b\u6f5c\u5728\u540c\u7c7b\u9996\u521b&nbsp;(first-in-class) PD-L1\/LAG-3\u53cc\u6297\u5df2\u83b7\u5f97IND\u6279\u4ef6\uff0c\u8ba1\u52122021\u5f00\u5c551\u671f\u4e34\u5e8a\u3002 TIGIT\u9886\u57df\uff1a\u516c\u53f8TIGIT\u5355\u6297\u7814\u53d1\u8fdb\u5ea6\u9886\u5148\uff0cIBI-939\u5df2\u8fdb\u5165\u4e34\u5e8a1b\u9636\u6bb5\uff0c\u8ba1\u52122021\u5e74\u53d6\u5f97PoC\u3002\u53e6\u6709PD-1\/TIGIT\u53cc\u6297IBI-321\u5df2\u7533\u62a5\u4e34\u5e8a\uff0c\u8ba1\u52122021\u5e74\u5f00\u5c55\u4e34\u5e8a\u3002 IBI-318\uff08PD1\/PDL1\u53cc\u6297\uff09\uff1a\u5df2\u5b8c\u62101a\u671f\u5242\u91cf\u63a2\u7d22\uff0c\u5e76\u4e8e2020\u5e74\u4e0b\u534a\u5e74\u8fdb\u5165\u591a\u98791b\u671f\u8bd5\u9a8c\u4ee5\u63a2\u7d22IBI-318\u5728\u4e0d\u540c\u764c\u75c7\u9002\u5e94\u75c7\u7684\u6f5c\u529b\u3002 \u72ec\u5177\u7279\u8272\u7684\u975e\u80bf\u7624\u7ba1\u7ebf 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2020\u5e74\u53ca2021\u5e74\u81f3\u4eca\u516c\u53f8\u4e0e\u56fd\u5185\u5916\u5408\u4f5c\u4f19\u4f34\u8fbe\u6210\u4e00\u7cfb\u5217\u6218\u7565\u5408\u4f5c\uff0c\u5176\u4e2d\uff1a 2020\u5e748\u6708\u4e0e\u793c\u6765\u5c31\u8fbe\u4f2f\u8212&reg;\u5728\u4e2d\u56fd\u5883\u5916\u7684\u72ec\u5bb6\u6743\u5229\u8ba2\u7acb\u7684\u6218\u7565\u6269\u5f20\u6388\u6743\u534f\u8bae\uff0c\u662f\u5c06\u516c\u53f8\u521b\u65b0\u4ea7\u54c1\u6218\u7565\u5f15\u5165\u56fd\u9645\u5e02\u573a\u7684\u91cc\u7a0b\u7891\u3002 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