{"id":24378,"date":"2021-03-26T07:00:00","date_gmt":"2021-03-26T00:00:00","guid":{"rendered":"https:\/\/www.xinwengao.com\/cn\/pr\/2021032607000024378"},"modified":"2021-03-26T21:38:37","modified_gmt":"2021-03-26T13:38:37","slug":"%e5%be%b7%e7%90%aa%e5%8c%bb%e8%8d%af%e5%85%ac%e5%b8%832020%e5%b9%b4%e5%85%a8%e5%b9%b4%e4%b8%9a%e7%bb%a9%e8%bf%9b%e5%b1%95","status":"publish","type":"post","link":"https:\/\/www.xinwengao.com\/cn\/pr\/2021032607000024378","title":{"rendered":"\u5fb7\u742a\u533b\u836f\u516c\u5e032020\u5e74\u5168\u5e74\u4e1a\u7ee9\u8fdb\u5c55"},"content":{"rendered":"<p><p><span id=\"spanHghlt503c\">\u4e0a\u6d77\u548c\u9999\u6e2f<\/span>2021\u5e743\u670826\u65e5 \/\u7f8e\u901a\u793e\/ &#8212; 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id=\"spanHghltba40\">12\u6b3e\u4e34\u5e8a\u8d44\u4ea7\uff0c\u5305\u62ec\u591a\u6b3e\u81ea\u4e3b\u7814\u53d1\u8d44\u4ea7\u3002<\/span>\u6211\u4eec\u6df1\u5316\u4e86\u4e0e\u884c\u4e1a\u9886\u5148\u7684\u751f\u7269\u5236\u836f\u516c\u53f8\u7684\u5408\u4f5c\uff0c\u83b7\u5f974\u6b3e\u5f15\u8fdb\u8d44\u4ea7\u572817\u4e2a\u4e9a\u592a\u5e02\u573a\u5f00\u53d1\u53ca\u5546\u4e1a\u5316\u7684\u6743\u76ca\u3002\u622a\u81f3\u4eca\u65e5\uff0c\u6211\u4eec\u63a5\u8fde\u57285\u4e2a\u4e9a\u592a\u5e02\u573a\u9012\u4ea4ATG-010\u7684\u65b0\u836f\u4e0a\u5e02\u7533\u8bf7\uff0c\u540c\u65f6\u52a0\u901f\u5b8c\u6210\u751f\u4ea7\u57fa\u5730\u7684\u4e00\u671f\u9879\u76ee\uff0c\u5e76\u5728\u4e2d\u56fd\u5927\u9646\u7b49\u591a\u4e2a\u4e9a\u592a\u5e02\u573a\u62d3\u5c55\u4e86\u5546\u4e1a\u5316\u56e2\u961f\uff1b\u6211\u4eec\u65b0\u589e6\u9879\u4e34\u5e8a\u8bd5\u9a8c\u7533\u8bf7\u83b7\u6279\uff0c<span id=\"spanHghlt11a3\">\u65b0\u589e3\u6b3e\u836f\u7269\u5728\u4e2d\u56fd\u3001\u6fb3\u5927\u5229\u4e9a\u5f00\u59cb\u8fdb\u884c\u4e34\u5e8a\u8bd5\u9a8c\u3002<\/span>\u6211\u4eec\u6210\u529f\u5b8c\u6210C\u8f6e\u878d\u8d44\u5e76\u5728\u9999\u6e2f\u8054\u4ea4\u6240\u6302\u724c\u4e0a\u5e02\uff0c\u4e0a\u5e024\u4e2a\u6708\u540e\u88ab\u7eb3\u5165\u6052\u751f\u7efc\u5408\u6307\u6570\u53ca\u6e2f\u80a1\u901a\uff1b\u6211\u4eec\u7684\u65b0\u836f\u7814\u53d1\u4e2d\u5fc3\u6b63\u5f0f\u8fd0\u8425\uff0c\u81ea\u4e3b\u7814\u53d1\u8fc8\u5165\u6b63\u8f68\uff1b\u6211\u4eec\u4e0e\u4e1a\u5185\u4e00\u6d41\u7684CRO\u540c\u6b65\u5f00\u5c55\u5408\u4f5c\uff0c\u52a0\u5feb\u4e86\u7814\u53d1\u8fdb\u7a0b\u3002\u81f3\u6b64\uff0c\u5fb7\u742a\u533b\u836f\u4ece\u7814\u53d1\u5230\u5546\u4e1a\u5316\u7684\u5168\u4ea7\u4e1a\u94fe\u6a21\u5f0f\u6e05\u6670\u53ef\u89c1\uff0c\u5145\u5206\u4f53\u73b0\u4e86\u6211\u4eec\u5177\u6709\u5c06\u7814\u53d1\u80fd\u529b\u8f6c\u5316\u4e3a\u5546\u4e1a\u6f5c\u529b\u7684\u5f3a\u5927\u5b9e\u529b\u3002\u201d<\/p>\n<p>\u201c\u5c55\u671b2021\uff0c\u6211\u4eec\u5c06\u4ee5\u60a3\u8005\u4e3a\u5148\uff0c\u7ee7\u7eed\u9012\u4ea4\u65b0\u836f\u4e0a\u5e02\u7533\u8bf7\uff0c\u8ba9\u5168\u7403\u60a3\u8005\u540c\u6b65\u5206\u4eab\u524d\u6cbf\u7684\u521b\u65b0\u7597\u6cd5\uff1b\u6211\u4eec\u5c06\u56f4\u7ed5\u2018\u8054\u5408\u3001\u4e92\u8865\u2019\u65b9\u9488\uff0c\u542f\u52a8\u591a\u9879\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u5728\u4f18\u5316\u73b0\u6709\u7597\u6cd5\u7684\u540c\u65f6\u586b\u8865\u9ad8\u53d1\u75be\u75c5\u7684\u4e34\u5e8a\u7a7a\u767d\uff1b\u6211\u4eec\u5c06\u5b8c\u5907\u4e2d\u56fd\u53ca\u4e9a\u592a\u5730\u533a\u7684\u5546\u4e1a\u5316\u4f53\u7cfb\uff0c\u63a8\u52a8\u6838\u5fc3\u4ea7\u54c1\u65e9\u65e5\u5e94\u7528\u4e8e\u60a3\u8005\uff1b\u6211\u4eec\u5c06\u8fbe\u6210\u66f4\u591a\u4f18\u8d28\u5408\u4f5c\uff0c\u8fdb\u4e00\u6b65\u63d0\u9ad8\u6838\u5fc3\u7ade\u4e89\u529b\uff1b\u6211\u4eec\u5c06\u5728\u56fd\u9645\u91cd\u8981\u4f1a\u8bae\u4e0a\u62ab\u9732\u4e34\u5e8a\u6570\u636e\uff0c<span id=\"spanHghltc4fd\">\u8fdb\u4e00\u6b65\u592f\u5b9e\u540c\u7c7b\u9996\u6b3e\u4ea7\u54c1\u5728\u591a\u4e2a\u5e02\u573a\u5546\u4e1a\u5316\u7684\u57fa\u7840\uff0c\u5e76\u540c\u6b65\u63a8\u52a8\u591a\u9879\u4e34\u5e8a\u524d\u5019\u9009\u836f\u7269\u8fdb\u5165\u4e34\u5e8a\u7814\u7a76\u3002<\/span>\u6700\u540e\uff0c\u5fb7\u742a\u5c06\u59cb\u7ec8\u6000\u63e3\u5bf9\u60a3\u8005\u7684\u8d64\u8bda\u4e4b\u5fc3\uff0c\u8df5\u884c\u533b\u8005\u4f7f\u547d\uff0c\u4e3a\u75c5\u60a3\u521b\u9020\u66f4\u591a\u4ef7\u503c\uff0c\u4e3a\u6295\u8d44\u8005\u4e89\u53d6\u66f4\u5927\u7684\u56de\u62a5\u3002\u201d<\/p>\n<p><b>\u4e34\u5e8a\u540e\u671f\u836f\u7269<\/b><\/p>\n<p><b>ATG-010<\/b><b>\uff08<\/b><b>selinexor,<\/b><b>\u540c\u7c7b\u9996\u6b3e<\/b><b>XPO1<\/b><b>\u6291\u5236\u5242\uff09<br \/><\/b><i>\u516c\u53f8\u6838\u5fc3\u7684\u6297\u8840\u6db2\u7624\u836f\u7269<\/i><i>ATG-010<\/i><i>\u5728\u4e34\u5e8a\u7814\u7a76\u548c\u6ce8\u518c\u65b9\u9762\u53d6\u5f97\u4e86\u91cd\u8981\u8fdb\u5c55\uff0c\u5df2\u5728\u542b\u4e2d\u56fd\u5927\u9646\u5728\u5185\u7684\u591a\u4e2a\u4e9a\u592a\u5e02\u573a\u63d0\u4ea4\u4e86\u65b0\u836f\u4e0a\u5e02\u7533\u8bf7\uff08<\/i><i>NDA<\/i><i>\uff09\u3002<\/i><\/p>\n<p><b><i>\u62a5\u544a\u671f\u5185\u8fdb\u5c55<\/i><\/b><\/p>\n<ul type=\"disc\">\n<li>2020\u5e7412\u67083\u65e5\uff0c\u516c\u53f8\u516c\u5e03\u5411<span id=\"spanHghlt2724\">\u6fb3\u5927\u5229\u4e9a\u836f\u54c1\u7ba1\u7406\u5c40<\/span>\uff08TGA\uff09\u548c\u65b0\u52a0\u5761\u536b\u751f\u79d1\u5b66\u5c40\uff08<span id=\"spanHghlta2d3\">HSA<\/span>\uff09\u63d0\u4ea4\u4e86ATG-010\u6cbb\u7597\u96be\u6cbb\u590d\u53d1\u6027\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\uff08rrMM\uff09\u6210\u4eba\u60a3\u8005\u548c\u96be\u6cbb\u590d\u53d1\u6027\u5f25\u6f2b\u6027\u5927B\u7ec6\u80de\u6dcb\u5df4\u7624\uff08rrDLBCL\uff09\u6210\u4eba\u60a3\u8005\u7684NDA\u3002\u4e8e\u6b64\u540c\u65f6\uff0c\u516c\u53f8\u5411\u9999\u6e2f\u536b\u751f\u7f72\u9012\u4ea4\u4e86ATG-010\u6cbb\u7597rrMM\u6210\u4eba\u60a3\u8005\u7684NDA\uff0c\u5e76\u4ee5\u5b64\u513f\u836f\u8d44\u683c\uff08ODD\uff09\u5411\u97e9\u56fd\u98df\u54c1\u836f\u54c1\u7ba1\u7406\u5c40\uff08MFDS\uff09\u9012\u4ea4\u4e86ATG-010\u6cbb\u7597rrMM\u548crrDLBCL\u6210\u4eba\u60a3\u8005\u7684NDA\u3002<\/li>\n<\/ul>\n<ul type=\"disc\">\n<li>ATG-010\u5728\u4e2d\u56fd\u5927\u9646\u8fdb\u884c\u4e86\u591a\u9879\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u5305\u62ec\uff1a<\/li>\n<\/ul>\n<p>1\uff09&nbsp;\u4e00\u9879\u8054\u5408\u4f4e\u5242\u91cf\u5730\u585e\u7c73\u677e\u6cbb\u7597rrMM\u7684II\u671f\u6ce8\u518c\u6027\u4e34\u5e8a\u8bd5\u9a8c\u3002<br \/>2\uff09&nbsp;\u4e00\u9879\u5355\u836f\u6cbb\u7597rrDLBCL\u7684II\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u5df2\u57282020\u5e74\u5b8c\u6210\u4e86\u9996\u4f8b\u60a3\u8005\u7ed9\u836f\u3002<br \/>3\uff09&nbsp;\u4e00\u9879\u8054\u5408\u787c\u66ff\u4f50\u7c73\u4e0e\u5730\u585e\u7c73\u677e\u6cbb\u7597rrMM\u7684III\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u8be5\u8bd5\u9a8c\u7684<span id=\"spanHghlt2b0e\">\u65b0\u836f<\/span>\u4e34\u5e8a\u8bd5\u9a8c\uff08IND\uff09<span id=\"spanHghlte942\">\u7533\u8bf7<\/span>\u4e8e2020\u5e74\u5e74\u5e95\u83b7\u5f97\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08NMPA\uff09\u6279\u51c6\u3002<br \/>4\uff09&nbsp;\u4e00\u9879\u5355\u836f\u6cbb\u7597\u5b50\u5bab\u5185\u819c\u764c\u7684III\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u516c\u53f8\u5df2\u4e8e2020\u5e7412\u6708\u5411NMPA\u63d0\u4ea4\u4e86IND\u7533\u8bf7\u3002<br \/>5\uff09&nbsp;\u4e3a\u8fdb\u4e00\u6b65\u53d1\u6398ATG-010\u6cbb\u7597\u80bf\u7624\u7684\u4e34\u5e8a\u6f5c\u529b\uff0c\u516c\u53f8\u542f\u52a8\u4e86\u591a\u9879\u65e9\u671f\u4fe1\u53f7\u68c0\u6d4b\u7814\u7a76\uff0c\u5305\u62ec\u8054\u5408\u5f02\u73af\u78f7\u9170\u80fa\u3001\u5361\u94c2\u548c\u4f9d\u6258\u6cca\u82f7\uff08ICE\uff09\u6216\u5409\u897f\u4ed6\u6ee8\u548c\u5965\u6c99\u5229\u94c2\uff08GemOx\uff09\u6cbb\u7597\u5916\u5468T\u7ec6\u80de\u6dcb\u5df4\u7624\u548cNK\/T\u7ec6\u80de\u6dcb\u5df4\u7624\u7684Ib\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u4ee5\u53ca\u6cbb\u7597KRAS\u7a81\u53d8\u7684\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff08NSCLC\uff09\u7684II\u671f\u4e34\u5e8a\u8bd5\u9a8c\u3002<\/p>\n<p><b><i>\u62a5\u544a\u671f\u540e\u8fdb\u5c55<\/i><\/b><\/p>\n<ul type=\"disc\">\n<li>2021\u5e741\u6708\uff0c\u516c\u53f8\u5411NMPA\u9012\u4ea4\u4e86ATG-010\u6cbb\u7597rrMM\u7684NDA\uff0c\u5e76\u83b7\u5f97\u4e86\u4f18\u5148\u5ba1\u8bc4<span id=\"spanHghltf0bf\">\u8d44\u683c<\/span>\u3002<\/li>\n<\/ul>\n<ul type=\"disc\">\n<li>2021\u5e741\u6708\uff0cNMPA\u6279\u51c6\u4e86\u4e00\u9879ATG-010\u8054\u5408R-GDP\u6cbb\u7597rrDLBCL\u7684II\/III\u671f\u4e34\u5e8a\u8bd5\u9a8c\u3002<\/li>\n<\/ul>\n<p><b><i>\u5408\u4f5c\u4f19\u4f34\u4e34\u5e8a\u8fdb\u5c55<\/i><\/b><\/p>\n<ul type=\"disc\">\n<li>2020\u5e746\u670822\u65e5\uff0cXPOVIO&reg;\uff08selinexor\uff09\u83b7\u5f97\u7f8e\u56fd\u98df\u54c1\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08U.S. FDA\uff09\u6279\u51c6\u6cbb\u7597\u4e8c\u7ebf\u4ee5\u4e0a\u5f25\u6f2b\u6027\u5927B\u7ec6\u80de\u6dcb\u5df4\u7624\u6210\u4eba\u60a3\u8005\u3002<\/li>\n<\/ul>\n<ul type=\"disc\">\n<li>2020\u5e7412\u670818\u65e5\uff0cXPOVIO&reg;&nbsp;(selinexor)\u83b7\u5f97\u7f8e\u56fdFDA\u6279\u51c6\u6cbb\u7597\u4e00\u7ebf\u4ee5\u4e0a\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\u6210\u4eba\u60a3\u8005\u3002<\/li>\n<\/ul>\n<p><b>ATG-008 (onatasertib, mTORC1\/2<\/b><b>\u6291\u5236\u5242<\/b><b>)<\/b><\/p>\n<p><b><i>\u62a5\u544a\u671f\u5185\u8fdb\u5c55<\/i><\/b><\/p>\n<ul type=\"disc\">\n<li>ATG-008\u7684\u4e00\u9879II\u671f\u4e34\u5e8a\u8bd5\u9a8c\u5b8c\u6210\u7b2c\u4e09\u4e2a\u5242\u91cf\u7ec4\u7684\u9996\u4f8b\u809d\u7ec6\u80de\u764c\uff08HCC\uff09\u60a3\u8005\u7ed9\u836f\u3002<\/li>\n<\/ul>\n<ul type=\"disc\">\n<li>\u516c\u53f8\u5728\u4e2d\u56fd\u5927\u9646\u542f\u52a8\u4e86\u4e00\u9879ATG-008\u8054\u5408PD-1\u6297\u4f53\u6cbb\u7597HCC\u548c\u665a\u671f\u5b9e\u4f53\u7624\u7684I\/II\u671f\u4e34\u5e8a\u8bd5\u9a8c\u4ee5\u53ca\u4e00\u9879ATG-008\u6cbb\u7597NFE2L2\u57fa\u56e0\u53d8\u5f02\u7684NSCLC\u7684II\u671f\u4e34\u5e8a\u8bd5\u9a8c\u3002<\/li>\n<\/ul>\n<ul type=\"disc\">\n<li>NMPA\u6279\u51c6ATG-008\u7528\u4e8e\u751f\u7269\u6807\u8bb0\u7269\u9a71\u52a8\u7684\u5b9e\u4f53\u7624\u7bee\u5b50\u8bd5\u9a8c\u7684IND\u7533\u8bf7\u3002<\/li>\n<\/ul>\n<p><b>\u5176\u4ed6\u4e34\u5e8a\u836f\u7269<\/b><\/p>\n<p><b>ATG-019<\/b><b>\uff08<\/b><b>PAK4\/NAMPT<\/b><b>\u53cc\u9776\u70b9\u6291\u5236\u5242\uff09<\/b><\/p>\n<p><b><i>\u62a5\u544a\u671f\u5185\u8fdb\u5c55<\/i><\/b><\/p>\n<p>ATG-019\u6cbb\u7597\u5b9e\u4f53\u7624\u548c\u6dcb\u5df4\u7624\u7684\u4e00\u9879I\u671f\u4e34\u5e8a\u8bd5\u9a8c\u5728\u4e2d\u56fd\u53f0\u6e7e\u5b8c\u6210\u9996\u4f8b\u60a3\u8005\u7ed9\u836f\u3002<\/p>\n<p><b><i>\u62a5\u544a\u671f\u540e\u8fdb\u5c55<\/i><\/b><\/p>\n<p>2021\u5e741\u6708\uff0c\u516c\u53f8\u5411&nbsp;NMPA\u9012\u4ea4ATG-019\u6cbb\u7597\u5b9e\u4f53\u7624\u548c\u6dcb\u5df4\u7624I\u671f\u4e34\u5e8a\u8bd5\u9a8c\u7684IND\u7533\u8bf7\u3002<\/p>\n<p><b>ATG-017 (ERK1\/2<\/b><b>\u6291\u5236\u5242<\/b><b>)<\/b><\/p>\n<p><b><i>\u62a5\u544a\u671f\u5185\u8fdb\u5c55<\/i><\/b><\/p>\n<p>ATG-017\u6cbb\u7597\u665a\u671f\u5b9e\u4f53\u7624\u548c\u8840\u6db2\u7624\u7684\u4e00\u9879I\u671f\u4e34\u5e8a\u8bd5\u9a8c\u5728\u6fb3\u5927\u5229\u4e9a\u5b8c\u6210\u9996\u4f8b\u60a3\u8005\u7ed9\u836f\u3002<\/p>\n<p><b>ATG-016 (eltanexor, <\/b><b>\u7b2c\u4e8c\u4ee3<\/b><b>XPO1<\/b><b>\u6291\u5236\u5242<\/b><b>)<\/b><\/p>\n<p><b><i>\u62a5\u544a\u671f\u5185\u8fdb\u5c55<\/i><\/b><\/p>\n<p>ATG-016\u6cbb\u7597\u9aa8\u9ad3\u589e\u751f\u5f02\u5e38\u7efc\u5408\u5f81\uff08MDS\uff09\u7684\u4e00\u9879I\/II\u671f\u4e34\u5e8a\u5b9e\u9a8c\u83b7NMPA\u6279\u51c6\u3002<\/p>\n<p><b><i>\u62a5\u544a\u671f\u540e\u8fdb\u5c55<\/i><\/b><\/p>\n<p>2021\u5e742\u6708\uff0c\u516c\u53f8\u5411NMPA\u63d0\u4ea4\u4e86ATG-016\u6cbb\u7597\u5b9e\u4f53\u7624\u7684I\/II\u671f\u4e34\u5e8a\u8bd5\u9a8c\u7684IND<span id=\"spanHghltdf1e\">\u7533\u8bf7<\/span>\u3002<\/p>\n<p><b>\u4e34\u5e8a\u524d\u836f\u7269<\/b><\/p>\n<p><i>\u516c\u53f8\u6b63\u5728\u7a33\u6b65\u63a8\u8fdb\u4e34\u5e8a\u524d\u836f\u7269\u7684\u5f00\u53d1\uff0c\u5305\u62ec<\/i><i>ATG-101<\/i><i>\uff08<\/i><i>PD-L1\/4-1BB<\/i><i>\u53cc\u7279\u5f02\u6027\u6297\u4f53\uff09\u3001<\/i><i>ATG-01<span id=\"spanHghltbf06\">8<\/span><\/i><i>\uff08<\/i><i>ATR<\/i><i>\u6291\u5236\u5242\uff09\u3001<\/i><i>ATG-022<\/i><i>\uff08<\/i><i>Claudin 18.2<\/i><i>\u6297\u4f53\u836f\u7269\u5076\u8054\u7269\uff09\u3001<\/i><i>ATG-012<\/i><i>\uff08<\/i><i>KRAS <\/i><i>\u6291\u5236\u5242\uff09\u548c\u5176\u4f59\u4e24\u4e2a\u672a\u62ab\u9732\u9776\u70b9\u7684\u751f\u7269\u836f\u3002<\/i><\/p>\n<p><b><i>\u62a5\u544a\u671f\u5185\u8fdb\u5c55<\/i><\/b><\/p>\n<ul type=\"disc\">\n<li><b>ATG-101<\/b><b>\uff08<\/b><b>PD-L1\/4-1BB<\/b><b>\u53cc\u7279\u5f02\u6027\u6297\u4f53\uff09<\/b><\/li>\n<\/ul>\n<p>ATG-101\u6b63\u5728\u8fdb\u884c\u65b0\u836f\u4e34\u5e8a\u7533\u62a5\u7814\u7a76\uff0c\u4ee5\u652f\u6301IND\/CTA\u7533\u8bf7\uff0c\u516c\u53f8\u8ba1\u5212\u4e8e2021\u5e74\u63d0\u4ea4\u7533\u8bf7\u3002<\/p>\n<ul type=\"disc\">\n<li><b>ATG-018 (ATR<\/b><b>\u6291\u5236\u5242<\/b><b>)<\/b><\/li>\n<\/ul>\n<p>ATG-018\u6b63\u5728\u8fdb\u884c\u4e34\u5e8a\u524d\u7814\u7a76\uff0c\u4ee5\u652f\u6301IND\/CTA\u7533\u8bf7\uff0c\u516c\u53f8\u8ba1\u5212\u4e8e2022\u5e74\u521d\u9012\u4ea4\u7533\u8bf7\u3002<\/p>\n<ul type=\"disc\">\n<li><b>ATG-022(Claudin 18.2<\/b><b>\u6297\u4f53\u836f\u7269\u5076\u8054\u7269<\/b><b>)<\/b><\/li>\n<\/ul>\n<p>ATG-022\u6b63\u5728\u8fdb\u884c\u4e34\u5e8a\u524d\u7814\u7a76\uff0c\u4ee5\u652f\u6301IND\/CTA\u7533\u8bf7\uff0c\u516c\u53f8\u8ba1\u5212\u4e8e2022\u5e74\u9012\u4ea4\u7533\u8bf7\u3002<\/p>\n<ul type=\"disc\">\n<li><b>ATG-012 (KRAS<\/b><b>\u6291\u5236\u5242<\/b><b>) <\/b><\/li>\n<\/ul>\n<p>ATG-012\u6b63\u5728\u8fdb\u884c\u4e34\u5e8a\u524d\u7814\u7a76\uff0c\u4ee5\u652f\u6301IND\/CTA\u7533\u8bf7\uff0c\u516c\u53f8\u8ba1\u5212\u4e8e2022\u5e74\u9012\u4ea4\u7533\u8bf7\u3002<\/p>\n<p><b>\u5176\u4ed6\u4e1a\u52a1\u8fdb\u5c55<\/b><\/p>\n<p><b><i>\u62a5\u544a\u671f\u5185\u8fdb\u5c55<\/i><\/b><\/p>\n<ul type=\"disc\">\n<li>\u516c\u53f8\u4efb\u547dJohn F. Chin\u5148\u751f\u4e3a\u9996\u5e2d\u5546\u52a1\u5b98\uff0c\u8d1f\u8d23\u516c\u53f8\u5168\u7403\u7684\u5546\u4e1a\u62d3\u5c55\uff1b\u4efb\u547dThomas Karalis\u5148\u751f\u4e3a\u4e9a\u592a\u5e02\u573a\u8d1f\u8d23\u4eba\uff0c\u8d1f\u8d23\u516c\u53f8\u4ea7\u54c1\u5728\u4e2d\u56fd\u53f0\u6e7e\u3001\u4e2d\u56fd\u9999\u6e2f\u3001\u6fb3\u5927\u5229\u4e9a\u3001\u65b0\u897f\u5170\u3001\u97e9\u56fd\u7b49\u4e9a\u592a\u5e02\u573a\u7684\u5546\u4e1a\u5316\uff1b\u4efb\u547d\u4fde\u5fd7\u6696\u535a\u58eb\u4e3a\u751f\u7269\u7edf\u8ba1\u53ca\u6cd5\u89c4\u53d1\u5c55\u96c6\u56e2\u526f\u603b\u88c1\uff0c\u8d1f\u8d23\u7ba1\u7ebf\u9879\u76ee\u7684\u6570\u636e\u7edf\u8ba1\u548c\u6cd5\u89c4\u6ce8\u518c\u6218\u7565\uff1b\u4efb\u547dDirk Hoenemann\u5148\u751f\u4e3a\u526f\u603b\u88c1\u53ca\u65e9\u671f\u4e34\u5e8a\u7814\u53d1\u548c\u4e9a\u592a\u5730\u533a\u533b\u5b66\u4e8b\u52a1\u8d1f\u8d23\u4eba\u3002<\/li>\n<\/ul>\n<ul type=\"disc\">\n<li>2020\u5e745\u6708\uff0c\u516c\u53f8\u8fdb\u4e00\u6b65\u52a0\u5f3a\u4e0eKaryopharm Therapeutics Inc.\u7684\u5408\u4f5c\uff0c\u83b7\u5f97selinexor, eltanexor, verdinexor \u548c&nbsp;ATG-019\u5728\u591a\u4e2a\u4e9a\u592a\u5e02\u573a\u751f\u4ea7\u53ca\u5546\u4e1a\u5316\u7684\u6743\u76ca\u3002<\/li>\n<\/ul>\n<ul type=\"disc\">\n<li>2020\u5e748\u6708\uff0c\u516c\u53f8\u4e0e\u7ecd\u5174\u6ee8\u6d77\u65b0\u533a\u7ba1\u59d4\u4f1a\u7b7e\u8ba2\u534f\u8bae\uff0c\u83b7\u5f97\u7ea616,300\u5e73\u65b9\u7c73\u7684\u751f\u4ea7\u57fa\u5730\uff0c\u7528\u4e8e\u5c0f\u5206\u5b50\u836f\u7269\u7684\u5546\u4e1a\u5316\u751f\u4ea7\u3002<\/li>\n<\/ul>\n<ul type=\"disc\">\n<li>2020\u5e7410\u6708\uff0c\u5fb7\u742a\u65b0\u836f\u7814\u53d1\u4e2d\u5fc3\u4e8e\u4e0a\u6d77\u5f20\u6c5f\u6b63\u5f0f\u542f\u7528\u3002<\/li>\n<\/ul>\n<ul type=\"disc\">\n<li>2020\u5e7411\u670820\u65e5\uff0c\u5fb7\u742a\u533b\u836f\u987a\u5229\u5728\u9999\u6e2f\u4ea4\u6613\u6240\u6302\u724c\u4e0a\u5e02\u3002<\/li>\n<\/ul>\n<ul type=\"disc\">\n<li>\u622a\u81f32020\u5e7412\u670831\u65e5\uff0c\u516c\u53f8\u5728\u4e2d\u56fd\u63d0\u4ea4\u4e868\u9879\u4e13\u5229\u7533\u8bf7\u3002<\/li>\n<\/ul>\n<p><b><i>\u62a5\u544a\u671f\u540e\u8fdb\u5c55<\/i><\/b><\/p>\n<ul type=\"disc\">\n<li>2021\u5e743\u6708\uff0c\u5fb7\u742a\u533b\u836f\u83b7\u7eb3\u5165\u6052\u751f\u7efc\u5408\u6307\u6570\u7b49\u4e5d\u4e2a\u57fa\u51c6\u53ca\u4e3b\u9898\u6307\u6570\u3002\u57fa\u4e8e\u6b64\u6b21\u8c03\u6574\u7ed3\u679c\uff0c\u516c\u53f8\u88ab\u7eb3\u5165\u6df1\u6e2f\u901a\u4e0b\u6e2f\u80a1\u901a\uff0c\u4e8e2021\u5e743\u670815\u65e5\u5f00\u59cb\u751f\u6548\u3002<\/li>\n<\/ul>\n<ul type=\"disc\">\n<li>2021\u5e743\u6708\uff0c\u516c\u53f8\u4efb\u547dKevin 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