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AR+\u8f6c\u79fb\u6027\u4e73\u817a\u764c\uff08\u4e2d\u56fd\uff09\uff1a\u6b63\u5728\u4e2d\u56fd\u5f00\u5c55\u5f00\u653e\u3001\u591a\u4e2d\u5fc3\u7684Ic\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u4ee5\u8bc4\u4f30\u666e\u514b\u9c81\u80fa\u8054\u5408\u4f9d\u897f\u7f8e\u5766\u3001\u6765\u66f2\u5511\u53ca\u6c1f\u7ef4\u53f8\u7fa4\u5bf9AR+\u8f6c\u79fb\u6027\u4e73\u817a\u764c\uff08mBC\uff09\u60a3\u8005\u7684\u5b89\u5168\u6027\u3001\u836f\u7269\u52a8\u529b\u5b66\u5206\u6790\u53ca\u521d\u6b65\u7597\u6548\u3002<\/p>\n

\u9884\u671f\u91cc\u7a0b\u7891<\/p>\n

\u63a8\u8fdb\u666e\u514b\u9c81\u80fa\u65b0\u51a0\u9002\u5e94\u75c7\u7684\u5546\u4e1a\u5316\u8fdb\u7a0b\u3002<\/p>\n

\u63a8\u8fdb\u666e\u514b\u9c81\u80fa\u6cbb\u7597mCRPC\u7684\u5355\u836f\u53ca\u4e0e\u963f\u6bd4\u7279\u9f99\u8054\u7528\u57282021\u5e74\u5e95\u9012\u4ea4\u4e0a\u5e02\u7533\u8bf7\u3002<\/p>\n

\u798f\u745e\u4ed6\u6069\uff08<\/b>KX-826\uff09\uff0c\u5916\u7528AR\u62ee\u6297\u5242
<\/b><\/p>\n

\u96c4\u6fc0\u7d20\u6027\u8131\u53d1\uff08\u4e2d\u56fd\uff09\uff1a2020\u5e749\u670817\u65e5\uff0c\u516c\u53f8\u798f\u745e\u4ed6\u6069\u51dd\u80f6\u5242\u578b\u9488\u5bf9\u96c4\u6fc0\u7d20\u6027\u8131\u53d1\u9002\u5e94\u75c7\u7684\u65b0\u836f\u7814\u7a76\u7533\u8bf7\u83b7\u5f97\u4e2d\u56fd\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u6279\u51c6\u30022020\u5e7412\u670829\u65e5\uff0c\u5df2\u5b8c\u6210\u5728\u4e2d\u56fd\u5f00\u5c55\u7684\u798f\u745e\u4ed6\u6069II\u671f\u4e34\u5e8a\u8bd5\u9a8c\u7684\u60a3\u8005\u62db\u52df\u3002<\/p>\n

\u96c4\u6fc0\u7d20\u6027\u8131\u53d1\uff08\u7f8e\u56fd\uff09\uff1a2020\u5e748\u6708\uff0c\u516c\u53f8\u5df2\u5728\u7f8e\u56fd\u5b8c\u6210\u798f\u745e\u4ed6\u6069Ib\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u6b63\u5728\u8fdb\u884c\u8bd5\u9a8c\u6570\u636e\u7684\u5206\u6790\u548c\u8bc4\u4f30\u3002<\/p>\n

\u75e4\u75ae\uff08\u4e2d\u56fd\uff09\uff1a2020\u5e749\u670817\u65e5\uff0c\u516c\u53f8\u798f\u745e\u4ed6\u6069\u51dd\u80f6\u5242\u578b\u9488\u5bf9\u75e4\u75ae\u9002\u5e94\u75c7\u7684\u65b0\u836f\u7814\u7a76\u7533\u8bf7\u83b7\u5f97\u4e2d\u56fd\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u6279\u51c6\u3002<\/p>\n

\u9884\u671f\u91cc\u7a0b\u7891<\/p>\n

\u4e8e2021\u5e74\u7b2c\u4e09\u5b63\u5ea6\u5b8c\u6210\u798f\u745e\u4ed6\u6069\u5728\u4e2d\u56fd\u9488\u5bf9\u96c4\u6fc0\u7d20\u6027\u8131\u53d1II\u671f\u4e34\u5e8a\u7814\u7a76\u62a5\u544a\u5e76\u53d1\u5e03\u6570\u636e\u3002<\/p>\n

\u4e8e2021\u5e74\u4e0a\u534a\u5e74\u5b8c\u6210\u798f\u745e\u4ed6\u6069\u5728\u7f8e\u56fd\u9488\u5bf9\u96c4\u6fc0\u7d20\u6027\u8131\u53d1\u7684Ib\u671f\u4e34\u5e8a\u7814\u7a76\u62a5\u544a\u5e76\u53d1\u5e03\u6570\u636e\u3002<\/p>\n

\u4e8e2021\u5e74\u7b2c\u4e8c\u5b63\u5ea6\u521d\u5b8c\u6210\u798f\u745e\u4ed6\u6069\u5728\u4e2d\u56fd\u9488\u5bf9\u75e4\u75ae\u7684I\u671f\u4e34\u5e8a\u8bd5\u9a8c\u9996\u4f8b\u53d7\u8bd5\u8005\u5165\u7ec4\uff0c\u8be5I\u671f\u4e34\u5e8a\u8bd5\u9a8c\u9884\u8ba1\u5c06\u4e8e2021\u5e74\u5b8c\u6210\u3002<\/p>\n

ALK-1(GT90001)\uff0c\u65b0\u578b\u6297\u8840\u7ba1\u751f\u6210\u6291\u5236\u5242
<\/b><\/p>\n

\u8f6c\u79fb\u6027\u809d\u7ec6\u80de\u764c\uff08\u4e2d\u56fd\u53f0\u6e7e\uff09\uff1a\u516c\u53f8\u6b63\u5728\u4e2d\u56fd\u53f0\u6e7e\u5f00\u5c55ALK-1\u5355\u6297\u4e0eNivolumab\u8054\u5408\u7528\u4e8e\u6cbb\u7597\u8f6c\u79fb\u6027\u809d\u7ec6\u80de\u764c\u7684II\u671f\u4e34\u5e8a\u8bd5\u9a8c\u30022021\u5e741\u6708\uff0c\u516c\u53f8\u5728ASCO GI\u4e0a\u516c\u5e03ALK-1\u5355\u6297\u4e0eNivolumab\u8054\u5408\u4e8c\u7ebf\u6cbb\u7597\u8f6c\u79fb\u6027\u809d\u7ec6\u80de\u764c\u7684\u53f0\u6e7e\u4e34\u5e8a\u8bd5\u9a8c\u6570\u636e\uff0c\u7ed3\u679c\u663e\u793a\u5ba2\u89c2\u7f13\u89e3\u7387\u4e3a40%\uff0c\u4e14\u5b89\u5168\u6027\u826f\u597d\u3002<\/p>\n

\u8f6c\u79fb\u6027\u809d\u7ec6\u80de\u764c\uff08\u7f8e\u56fd\uff09\uff1a2021\u5e742\u670811\u65e5\uff0c\u7f8e\u56fdFDA\u6279\u51c6ALK-1\u5355\u6297\u8054\u5408Nivolumab\u7528\u4e8e\u4e8c\u7ebf\u6cbb\u7597\u665a\u671f\u809d\u7ec6\u80de\u764cII\u671f\u4e34\u5e8a\u8bd5\u9a8c\u3002<\/p>\n

\u8fea\u62d3\u8d5b\u66ff\uff08<\/b>GT0486\uff09\uff0cPI3K\/mTOR\u4fe1\u53f7\u9014\u5f84\u6291\u5236\u5242<\/b><\/p>\n

\u8f6c\u79fb\u6027\u5b9e\u4f53\u7624\uff08\u4e2d\u56fd\uff09\uff1a\u5df2\u4e8e2019\u5e748\u6708\u83b7\u5f97\u4e2d\u56fd\u7684IND\u6279\u51c6\uff0c\u8fea\u62d3\u8d5b\u66ff\u662f\u7b2c\u4e8c\u4ee3 mTOR\u6291\u5236\u5242\uff0c\u53ef\u540c\u65f6\u6291\u5236 mTORC1\u548c mTORC2\uff0c\u76ee\u524d\u6b63\u5904\u4e8eI\u671f\u4e34\u5e8a\u8bd5\u9a8c\u5242\u91cf\u722c\u5761\u9636\u6bb5\u3002<\/p>\n

\u9884\u671f\u91cc\u7a0b\u7891<\/p>\n

\u4e8e2021\u5e74\u5b8c\u6210GT0486\u5728\u4e2d\u56fd\u7684I\u671f\u4e34\u5e8a\u8bd5\u9a8c\u3002<\/p>\n

GT1708F\uff08Hedgehog\/SMO\u6291\u5236\u5242\uff09\uff0chedgehog\u4fe1\u53f7\u8f6c\u5bfc\u9014\u5f84\u6291\u5236\u5242<\/b><\/p>\n

\u767d\u8840\u75c5\u548c\u57fa\u5e95\u7ec6\u80de\u764c\uff08\u4e2d\u56fd\uff09\uff1a\u5df2\u4e8e2020\u5e742\u6708\u83b7\u5f97\u4e2d\u56fd\u7684IND\u6279\u51c6\uff0c\u76ee\u524d\u6b63\u5904\u4e8eI\u671f\u4e34\u5e8a\u8bd5\u9a8c\u5242\u91cf\u722c\u5761\u9636\u6bb5\u3002<\/p>\n

\u57fa\u5e95\u7ec6\u80de\u764c\uff08\u7f8e\u56fd\uff09\uff1a2020\u5e7411\u6708\u83b7\u5f97\u7f8e\u56fdFDA\u7684\u53d7\u7406\uff0c\u7528\u4e8e\u57fa\u5e95\u7ec6\u80de\u764c\u9002\u5e94\u75c7\u3002<\/p>\n

\u9884\u671f\u91cc\u7a0b\u7891<\/p>\n

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GT20029\uff0cPROTAC-AR\u964d\u89e3\u5242<\/b><\/p>\n

\u96c4\u6fc0\u7d20\u6027\u8131\u53d1\u548c\u75e4\u75ae\uff08\u4e2d\u56fd\uff09\uff1a\u5df2\u4e8e2021\u5e742\u6708IND\u83b7CDE\u53d7\u7406\uff0c\u7528\u4e8e\u96c4\u6fc0\u7d20\u6027\u8131\u53d1\u548c\u75e4\u75ae\u7684\u6cbb\u7597\uff0c\u662f\u5168\u7403\u9996\u4e2a\u57fa\u4e8ePROTAC\u6280\u672f\u5f00\u53d1\u7684\u5916\u7528AR\u964d\u89e3\u5242\u3002<\/p>\n

\u9884\u671f\u91cc\u7a0b\u7891<\/p>\n

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\u751f\u4ea7\u57fa\u5730<\/b><\/p>\n

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\u5e73\u6e56\uff1a<\/b>\u4f4d\u4e8e\u6d59\u6c5f\u7701\u5e73\u6e56\u53bf\u7684\u539f\u6599\u836f\u548c\u5236\u5242\u751f\u4ea7\u57fa\u5730\u9879\u76ee\uff0c\u7ea6\u5360\u57304\u4e07\u5e73\u65b9\u7c73\u3002\u9879\u76ee\u8bbe\u8ba1\u5df2\u7ecf\u542f\u52a8\uff0c\u9884\u8ba12021\u5e74\u7b2c\u4e09\u5b63\u5ea6\u5f00\u5de5\uff0c2022\u5e74\u5e74\u5e95\u524d\u5b8c\u6210\u5efa\u8bbe\u3002<\/p>\n

\u5546\u4e1a\u5316\u5408\u4f5c<\/b><\/p>\n

\u798f\u745e\u4ed6\u6069\u5546\u4e1a\u5316\u5408\u4f5c<\/b><\/p>\n

2020\u5e746\u6708\uff0c\u516c\u53f8\u4e0e\u4eac\u4e1c\u5065\u5eb7\u7b7e\u7f72\u6218\u7565\u5408\u4f5c\u6846\u67b6\u534f\u8bae\uff0c\u53cc\u65b9\u5c31\u798f\u745e\u4ed6\u6069\u5728\u4eac\u4e1c\u5065\u5eb7\u8fd0\u8425\u7684\u7ebf\u4e0a\u836f\u54c1\u96f6\u552e\u5e73\u53f0\u4eac\u4e1c\u5927\u836f\u623f\u7684\u8425\u9500\u5c55\u5f00\u6df1\u5165\u5408\u4f5c\u3002<\/p>\n

2020\u5e743\u6708\uff0c\u516c\u53f8\u4e0e\u56fd\u836f\u63a7\u80a1\u80a1\u4efd\u6709\u9650\u516c\u53f8\u7b7e\u7f72\u4e86\u5408\u4f5c\u534f\u8bae\uff0c\u5c06\u5728\u4ea7\u54c1\u8bbe\u8ba1\u3001\u5546\u4e1a\u6e20\u9053\u62d3\u5c55\u3001\u7ec8\u7aef\u670d\u52a1\u7b49\u65b9\u9762\u5f00\u5c55\u5168\u65b9\u4f4d\u5408\u4f5c\u3002<\/p>\n

\u4e0e\u5eb7\u5b81\u6770\u745e\u5408\u4f5c<\/b><\/p>\n

2020\u5e747\u6708\uff0c\u516c\u53f8\u4e0e\u5eb7\u5b81\u6770\u745e\u8fbe\u6210\u5408\u4f5c\uff0c\u5171\u540c\u63a8\u8fdbALK-1\u5355\u6297\u8054\u5408\u91cd\u7ec4\u4eba\u6e90\u5316PD-L1\/CTLA-4\u53cc\u7279\u5f02\u6027\u6297\u4f53KN046\u6cbb\u7597\u809d\u7ec6\u80de\u764c\u7b49\u80bf\u7624\u5728\u5168\u7403\u8303\u56f4\u5185\u7684\u4e34\u5e8a\u7814\u7a76\u3002<\/p>\n

\u4e0e\u7f8e\u56fd<\/b>Gensun\u5408\u4f5c<\/b><\/p>\n

2020\u5e748\u6708\uff0c\u516c\u53f8\u4e0e\u7f8e\u56fd Gensun\u516c\u53f8\u5c31PD-L1\/ TGF-\u03b2\u53cc\u9776\u70b9\u6297\u4f53GS19\u7b7e\u7f72\u72ec\u5bb6\u8bb8\u53ef\u534f\u8bae\uff0c\u5f00\u62d3\u836f\u4e1a\u83b7\u5f97GS19\u5728\u5927\u4e2d\u534e\u533a\u8fdb\u884c\u4e34\u5e8a\u5f00\u53d1\u53ca\u5546\u4e1a\u5316\u7684\u72ec\u5bb6\u6743\u5229\u3002<\/p>\n

\u4e0e\u8fc8\u767e\u745e\u5408\u4f5c<\/b><\/p>\n

2020\u5e749\u6708\uff0c\u516c\u53f8\u4e0e\u8fc8\u767e\u745e\u56fd\u9645\u751f\u7269\u533b\u836f\u6709\u9650\u516c\u53f8\u7b7e\u7f72\u6218\u7565\u5408\u4f5c\u534f\u8bae\uff0c\u53cc\u65b9\u5c31\u751f\u7269\u5927\u5206\u5b50\u836f\u7269\u7684\u7814\u53d1\u4e0e\u751f\u4ea7\u5c55\u5f00\u5168\u65b9\u4f4d\u5408\u4f5c\u3002<\/p>\n

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\u5168\u7403\u5316\u5e03\u5c40<\/b><\/p>\n

 <\/p>\n

\n

\"\"<\/a>
<\/span><\/p>\n<\/p><\/div>\n

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2020\u5e74\u5168\u5e74\u8d22\u52a1\u4e1a\u7ee9<\/b><\/p>\n

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<\/div>\n

\u76f8\u5173\u94fe\u63a5 :<\/p>\n

http:\/\/www.kintor.com.cn<\/p>\n","protected":false},"excerpt":{"rendered":"

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