{"id":20819,"date":"2021-02-23T08:23:00","date_gmt":"2021-02-23T01:23:00","guid":{"rendered":"https:\/\/www.xinwengao.com\/cn\/pr\/2021022308230020819"},"modified":"2021-02-23T21:39:57","modified_gmt":"2021-02-23T13:39:57","slug":"%e4%bf%a1%e8%be%be%e7%94%9f%e7%89%a9%e4%b8%8e%e9%a9%af%e9%b9%bf%e5%8c%bb%e7%96%97%e5%90%88%e4%bd%9c%e5%bc%80%e5%8f%91%e7%9a%84bcma-car-t%e8%8e%b7%e5%9b%bd%e5%ae%b6%e8%8d%af%e7%9b%91%e5%b1%80%e7%aa%81","status":"publish","type":"post","link":"https:\/\/www.xinwengao.com\/cn\/pr\/2021022308230020819","title":{"rendered":"\u4fe1\u8fbe\u751f\u7269\u4e0e\u9a6f\u9e7f\u533b\u7597\u5408\u4f5c\u5f00\u53d1\u7684BCMA CAR-T\u83b7\u56fd\u5bb6\u836f\u76d1\u5c40\u7a81\u7834\u6027\u6cbb\u7597\u836f\u7269\u8ba4\u5b9a \u7528\u4e8e\u6cbb\u7597\u590d\u53d1\u96be\u6cbb\u6027\u591a\u53d1\u6027\u9aa8\u9ad3\u7624"},"content":{"rendered":"

\u7f8e\u56fd\u65e7\u91d1\u5c71\u548c\u4e2d\u56fd\u82cf\u5dde2021\u5e742\u670823\u65e5 \/\u7f8e\u901a\u793e\/ — \u4fe1\u8fbe\u751f\u7269\u5236\u836f\uff08\u9999\u6e2f\u8054\u4ea4\u6240\u80a1\u7968\u4ee3\u7801\uff1a01801\uff09\uff0c\u4e00\u5bb6\u81f4\u529b\u4e8e\u7814\u53d1\u3001\u751f\u4ea7\u548c\u9500\u552e\u7528\u4e8e\u6cbb\u7597\u80bf\u7624\u3001\u4ee3\u8c22\u75be\u75c5\u3001\u81ea\u8eab\u514d\u75ab\u7b49\u91cd\u5927\u75be\u75c5\u7684\u521b\u65b0\u836f\u7269\u7684\u751f\u7269\u5236\u836f\u516c\u53f8\uff0c\u4eca\u65e5\u548c\u9a6f\u9e7f\u533b\u7597\u5171\u540c\u5ba3\u5e03\uff0c\u7531\u53cc\u65b9\u5408\u4f5c\u5f00\u53d1\u7684\u5168\u4eba\u6e90BCMA\u5d4c\u5408\u6297\u539f\u53d7\u4f53\u81ea\u4f53T\u7ec6\u80de\u6ce8\u5c04\u6db2\uff08\u4fe1\u8fbe\u751f\u7269\u7814\u53d1\u4ee3\u53f7\uff1aIBI326\uff1b\u9a6f\u9e7f\u533b\u7597\u7814\u53d1\u4ee3\u53f7\uff1aCT103A\uff09\u901a\u8fc7\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08NMPA\uff09\u836f\u54c1\u5ba1\u8bc4\u4e2d\u5fc3\uff08CDE\uff09\u516c\u793a\u671f\uff0c\u7eb3\u5165\u201c\u7a81\u7834\u6027\u6cbb\u7597\u836f\u7269\u54c1\u79cd\u201d\uff0c\u62df\u5b9a\u9002\u5e94\u75c7\u4e3a\u590d\u53d1\/\u96be\u6cbb\u6027\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\uff08R\/R MM\uff09\u3002\u83b7\u5f97\u7a81\u7834\u6027\u6cbb\u7597\u836f\u7269\u8ba4\u5b9a\u80fd\u591f\u4f7f\u8be5\u836f\u5728\u7814\u53d1\u8fc7\u7a0b\u4e2d\u4e0eCDE\u5bc6\u5207\u4ea4\u6d41\u3001\u83b7\u5f97\u6307\u5bfc\uff0c\u4ece\u800c\u52a0\u5feb\u65b0\u836f\u4e0a\u5e02\uff0c\u66f4\u65e9\u89e3\u51b3\u4e2d\u56fd\u75c5\u60a3\u672a\u6ee1\u8db3\u7684\u4e34\u5e8a\u9700\u6c42\u3002IBI326\u672c\u6b21\u7a81\u7834\u6027\u6cbb\u7597\u836f\u7269\u7684\u8ba4\u5b9a\u662f\u57fa\u4e8e\u6b63\u5728\u4e2d\u56fd\u8fdb\u884c\u7684\u6cbb\u7597R\/R MM \u76841\/2\u671f\u7814\u7a76\uff08ChiCTR1800018137\uff09\u4e2d\u89c2\u5bdf\u5230\u7684\u7ed3\u679c\u3002<\/p>\n

IBI326\u662f\u4e00\u79cd\u9488\u5bf9B\u7ec6\u80de\u6210\u719f\u6297\u539f\uff08BCMA\uff09\u7684CAR-T\u7ec6\u80de\u7597\u6cd5\uff0c\u4ee5\u6162\u75c5\u6bd2\u4e3a\u57fa\u56e0\u8f7d\u4f53\u8f6c\u67d3\u81ea\u4f53T\u7ec6\u80de\uff0cCAR\u5305\u542b\u5168\u4eba\u6e90scFv\u3001CD8a \u94f0\u94fe\u548c\u8de8\u819c\u30014-1BB\u5171\u523a\u6fc0\u548cCD3\u03b6<\/span>\u6fc0\u6d3b\u7ed3\u6784\u57df\u3002\u57fa\u4e8e\u4e25\u683c\u7684\u7b5b\u9009\uff0c\u901a\u8fc7\u5168\u9762\u7684\u4f53\u5185\u5916\u529f\u80fd\u8bc4\u4ef7\uff0cIBI326\u5177\u6709\u5f3a\u529b\u3001\u5feb\u901f\u548c\u6301\u4e45\u7684\u7597\u6548\u3002<\/p>\n

\u57282019\u5e74\u4e3e\u884c\u7684\u7b2c61\u5c4a\u7f8e\u56fd\u8840\u6db2\u5b66\u5e74\u4f1a\uff08ASH\uff09\u4e0a\uff0c\u9a6f\u9e7f\u533b\u7597\u4e0e\u4fe1\u8fbe\u751f\u7269\u4e00\u8d77\u53e3\u5934\u62a5\u544a\u4e86\u53cc\u65b9\u5171\u540c\u7814\u53d1\u7684\u5168\u4eba\u6e90BCMA CAR-T\u6cbb\u7597\u590d\u53d1\/\u96be\u6cbb\u6027\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\u7684\u4e00\u9879\u4e34\u5e8a\u7814\u7a76\u6570\u636e\u3002\uff08\u6458\u8981#582\uff09\u6570\u636e\u8868\u660eIBI326\u83b7\u5f97\u4e86\u826f\u597d\u7684\u5b89\u5168\u6027\u3001\u6709\u6548\u6027\u548c\u5e94\u7b54\u6301\u4e45\u6027\u3002\u503c\u5f97\u4e00\u63d0\u7684\u662f\uff0c\u8be5\u7814\u7a76\u8fd8\u5305\u62ec4\u540d\u5148\u524d\u5df2\u63a5\u53d7\u8fc7\u9f20\u6e90\u6297BCMA CAR-T\u6cbb\u7597\u540e\u590d\u53d1\u7684\u60a3\u8005\uff0c\u4ed6\u4eec\u7684\u6574\u4f53\u8868\u73b0\u8868\u660eIBI326\u8fd8\u53ef\u4e3a\u9f20\u6e90\u6027CAR-T\u6cbb\u7597\u540e\u590d\u53d1\u7684\u60a3\u8005\u63d0\u4f9b\u6709\u6548\u6cbb\u7597\u7684\u9009\u62e9\u3002<\/p>\n

2021\u5e741\u6708\uff0c\u8fd9\u4e00\u521b\u65b0\u836f\u7269\u7684\u6700\u65b0\u4e34\u5e8a\u7814\u7a76\u6210\u679c\u518d\u83b7\u56fd\u9645\u6743\u5a01\u8ba4\u53ef — \u7531\u9a6f\u9e7f\u533b\u7597\u4e0e\u534e\u4e2d\u79d1\u6280\u5927\u5b66\u9644\u5c5e\u540c\u6d4e\u533b\u9662\u8840\u6db2\u79d1\u5468\u5251\u5cf0\u6559\u6388\u56e2\u961f\u5408\u4f5c\u7684\u201c\u5168\u4eba\u6e90BCMA CAR-T\u6cbb\u7597\u590d\u53d1\u96be\u6cbb\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\u7597\u6548\u53ca\u5b89\u5168\u6027\u201d\u7684\u6700\u65b0\u7814\u7a76\u6210\u679c\u53d1\u8868\u5728\u8840\u6db2\u5b66\u8457\u540d\u5b66\u672f\u671f\u520a\u300aBlood\u300b\u4e2d\u3002\uff08\u201cA Phase 1 Study of a Novel Fully Human BCMA-targeting CAR (IBI326) in Patients with Relapsed\/Refractory Multiple Myeloma.<\/a>\u201d\uff09<\/p>\n

\u4fe1\u8fbe\u751f\u7269\u533b\u5b66\u79d1\u5b66\u4e0e\u6218\u7565\u80bf\u7624\u90e8\u526f\u603b\u88c1\u5468\u8f89\u535a\u58eb\u8868\u793a\uff1a\u201cIBI326\u7eb3\u5165CDE\u7a81\u7834\u6027\u6cbb\u7597\u836f\u7269\u7a0b\u5e8f\uff0c\u8bf4\u660e\u4e86\u8be5\u6b3e\u836f\u7269\u5728\u6cbb\u7597\u590d\u53d1\u96be\u6cbb\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\u6781\u5177\u6f5c\u529b\uff0c\u5e0c\u671b\u8be5\u6b3e\u836f\u7269\u65e9\u65e5\u4e0a\u5e02\u60e0\u53ca\u66f4\u591a\u7684\u60a3\u8005\u3002\u201d<\/p>\n

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\u5173\u4e8e IBI326<\/b><\/p>\n

IBI326\u662f\u7531\u4fe1\u8fbe\u751f\u7269\u548c\u9a6f\u9e7f\u533b\u7597\u5236\u836f\u8054\u5408\u5f00\u53d1\u7684\u4e00\u79cd\u521b\u65b0\u4ea7\u54c1\u3002\u672c\u4ea7\u54c1\u4ee5\u6162\u75c5\u6bd2\u4e3a\u57fa\u56e0\u8f7d\u4f53\u8f6c\u67d3\u81ea\u4f53T\u7ec6\u80de\uff0cCAR\u5305\u542b\u5168\u4eba\u6e90scFv\u3001CD8a \u94f0\u94fe\u548c\u8de8\u819c\u30014-1BB\u5171\u523a\u6fc0\u548cCD3\u03b6<\/span>\u6fc0\u6d3b\u7ed3\u6784\u57df\u3002\u57fa\u4e8e\u4e25\u683c\u7684\u7b5b\u9009\uff0c\u901a\u8fc7\u5168\u9762\u7684\u4f53\u5185\u5916\u529f\u80fd\u8bc4\u4ef7\uff0cIBI326 CAR-T\u4ea7\u54c1\u5177\u6709\u5f3a\u6709\u529b\u548c\u5feb\u901f\u7684\u7597\u6548\uff0c\u5e76\u6709\u7a81\u51fa\u7684\u6301\u4e45\u6027\u3002<\/p>\n

\u5173\u4e8e\u591a\u53d1\u6027\u9aa8\u9ad3\u7624<\/b><\/p>\n

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\u5173\u4e8e\u7a81\u7834\u6027\u6cbb\u7597\u836f\u7269\u7a0b\u5e8f<\/b><\/p>\n

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