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\n

\"\"<\/a>
<\/span><\/p>\n<\/p><\/div>\n

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\u768468\u5c81\u5973\u6027\u773c\u90e8\u9ed1\u8272\u7d20\u7624\u809d\u8f6c\u79fb\u53d7\u8bd5\u8005\uff0c\u5728\u65e2\u5f80\u63a5\u53d7Nivolumab\u4e00\u4e2a\u5468\u671f\u8fdb\u5c55\uff0cNivolumab\u4e0eIpilimumab\u8054\u7528\u6cbb\u7597\u4e00\u4e2a\u5468\u671f\u53c8\u8fdb\u5c55\u540e\uff0c\u4e8e2020\u5e7410\u670819\u65e5\u5165\u7ec4\u672c\u7814\u7a76YH003 \u76840.1mg\/kg\u5242\u91cf\u7ec4\u3002\u5728YH003\u5355\u836f\u6cbb\u7597\u4e00\u4e2a\u5468\u671f\uff0821\u5929\/\u5468\u671f\uff09\u540e\uff0c\u4e0e\u7279\u745e\u666e\u5229\u5355\u6297\u6ce8\u5c04\u6db2\uff08Toripalimab\uff09 240mg\u8054\u5408\u6cbb\u7597\uff0c\u622a\u6b622021\u5e741\u67087\u65e5\uff0c\u8be5\u53d7\u8bd5\u8005\u5df2\u7ecf\u63a5\u53d74\u4e2a\u5468\u671f\u517112\u5468\u7684\u7814\u7a76\u836f\u7269\u6cbb\u7597\uff0c\u6cbb\u7597\u540e\u7b2c10\u5468\u5f71\u50cf\u5b66\u8bc4\u4f30\u603b\u4f53\u5e94\u7b54\u4e3a\u90e8\u5206\u7f13\u89e3\uff08Partial Response\uff09\uff0c\u5176\u9776\u75c5\u7076\u76f4\u5f84\u603b\u548c\u8f83\u57fa\u7ebf\u7f29\u5c0f38.5%\uff0c\u672a\u89c2\u5bdf\u5230\u5242\u91cf\u9650\u5236\u6027\u6bd2\u6027(DLT)\u4e8b\u4ef6\uff0c\u672a\u53d1\u751f\u4e0e\u7814\u7a76\u836f\u7269\u76f8\u5173\u7684\u4e0d\u826f\u4e8b\u4ef6\u3002\u6b64\u9879\u540d\u4e3aYH003002\u7684\u4e34\u5e8a\u7814\u7a76\u65e8\u5728\u8bc4\u4f30CD40 (YH003) \u8054\u5408\u7279\u745e\u666e\u5229\u5355\u6297\u5728\u6fb3\u6d32\u5b9e\u4f53\u7624\u60a3\u8005\u7684\u5b89\u5168\u6027\u3001\u8010\u53d7\u6027\u3001\u836f\u4ee3\u52a8\u529b\u5b66\u548c\u521d\u6b65\u7597\u6548\u3002 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