{"id":16495,"date":"2021-01-05T07:33:00","date_gmt":"2021-01-05T00:33:00","guid":{"rendered":"https:\/\/www.xinwengao.com\/cn\/pr\/2021010507330016495"},"modified":"2021-01-05T09:12:52","modified_gmt":"2021-01-05T01:12:52","slug":"%e4%ba%9a%e7%9b%9b%e5%8c%bb%e8%8d%af%e6%96%a9%e8%8e%b7%e7%ac%ac9%e9%a1%b9fda%e5%ad%a4%e5%84%bf%e8%8d%af%e8%b5%84%e6%a0%bc%e8%ae%a4%e5%ae%9a%ef%bc%8c%e5%88%9b%e4%b8%ad%e5%9b%bd%e8%8d%af%e4%bc%81","status":"publish","type":"post","link":"https:\/\/www.xinwengao.com\/cn\/pr\/2021010507330016495","title":{"rendered":"\u4e9a\u76db\u533b\u836f\u65a9\u83b7\u7b2c9\u9879FDA\u5b64\u513f\u836f\u8d44\u683c\u8ba4\u5b9a\uff0c\u521b\u4e2d\u56fd\u836f\u4f01\u4e4b\u6700"},"content":{"rendered":"<table border=\"0\" cellspacing=\"10\" cellpadding=\"5\" align=\"right\">\n<tbody>\n<tr>\n<td><img decoding=\"async\" src=\"https:\/\/www.xinwengao.com\/cn\/wp-content\/uploads\/Ascentage_Pharma_Logo-5.jpg\" border=\"0\" alt=\"\" title=\"logo\" hspace=\"0\" vspace=\"0\" width=\"118\" \/><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><p>\u4e2d\u56fd\u82cf\u5dde\u548c\u7f8e\u56fd\u9a6c\u91cc\u5170\u5dde\u7f57\u514b\u7ef4\u5c14\u5e022021\u5e741\u67085\u65e5 \/\u7f8e\u901a\u793e\/ &#8212; \u81f4\u529b\u4e8e\u5728\u80bf\u7624\u3001\u4e59\u809d\u53ca\u4e0e\u8870\u8001\u76f8\u5173\u75be\u75c5\u7b49\u6cbb\u7597\u9886\u57df\u5f00\u53d1\u521b\u65b0\u836f\u7269\u7684\u5904\u4e8e\u4e34\u5e8a\u9636\u6bb5\u7684\u7814\u53d1\u4f01\u4e1a\u2013 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class=\"PRN_ImbeddedAssetReference\" id=\"DivAssetPlaceHolder1\">\n<\/p><\/div>\n<p>AML\u662f\u4e00\u79cd\u5177\u6709\u9ad8\u5ea6\u5f02\u8d28\u6027\u7684\u8840\u6db2\u7cfb\u7edf\u6076\u6027\u80bf\u7624\uff0c\u4e14\u4e3b\u8981\u4e3a\u4e00\u79cd\u8001\u5e74\u60a3\u8005\u75be\u75c5\uff0c\u8bca\u65ad\u65f6\u7684\u4e2d\u4f4d\u5e74\u9f84\u4e3a68\u5c81<sup>[1]<\/sup>\u3002\u7f8e\u56fd\u56fd\u5bb6\u764c\u75c7\u6240\u6700\u65b0\u7684SEER\uff08Surveillance Epidemiology and End Results Program\uff09\u9884\u4f30\u6570\u636e\u663e\u793a\uff0c2020\u5e74\u7f8e\u56fd\u5c06\u670919940\u4f8b\u65b0\u8bcaAML\u75c5\u4f8b\uff0c\u5e76\u5c06\u670911180\u4eba\u6b7b\u4e8e\u8be5\u75be\u75c5\u3002\u5c3d\u7ba1\u8fd1\u5e74\u6765\u5728AML\u7684\u6cbb\u7597\u65b9\u9762\u53d6\u5f97\u4e86\u4e00\u5b9a\u8fdb\u5c55\uff0c\u4f46\u8be5\u75be\u75c5\u76845\u5e74\u751f\u5b58\u7387\u4e3a25%-30%\uff0c\u56e0\u6b64\u4e34\u5e8a\u4e0a\u4ecd\u8feb\u5207\u9700\u8981\u66f4\u5b89\u5168\u3001\u66f4\u6301\u4e45\u6709\u6548\u7684\u6cbb\u7597\u624b\u6bb5\u3002<\/p>\n<p>\u201c\u5b64\u513f\u836f\u201d\u53c8\u79f0\u4e3a\u7f55\u89c1\u836f\uff0c\u6307\u7528\u4e8e\u9884\u9632\u3001\u6cbb\u7597\u3001\u8bca\u65ad\u7f55\u89c1\u75c5\u7684\u836f\u54c1\u3002\u5728\u7f8e\u56fd\uff0c\u7f55\u89c1\u75be\u75c5\u662f\u6307\u60a3\u75c5\u4eba\u6570\u5c11\u4e8e20\u4e07\u4eba\u7684\u75be\u75c5\u3002\u81ea1983\u5e74\u4ee5\u6765\uff0c\u7f8e\u56fd\u901a\u8fc7\u300a\u5b64\u513f\u836f\u6cd5\u6848\u300b\u7684\u5b9e\u65bd\uff0c\u7ed9\u4e88\u4f01\u4e1a\u76f8\u5173\u653f\u7b56\u6276\u6301\uff0c\u4ee5\u9f13\u52b1\u7f55\u89c1\u75c5\u836f\u54c1\u7684\u7814\u53d1\u3002\u83b7\u5f97\u7f8e\u56fdFDA\u6388\u4e88\u7684\u5b64\u513f\u836f\u8d44\u683c\u8ba4\u5b9a\uff0c\u5c06\u6709\u52a9\u4e8e\u8be5\u836f\u7269\u5728\u7f8e\u56fd\u7684\u540e\u7eed\u7814\u53d1\u53ca\u5546\u4e1a\u5316\u5f00\u5c55\u7b49\u65b9\u9762\u4eab\u53d7\u4e00\u5b9a\u7684\u653f\u7b56\u652f\u6301\uff0c\u5305\u62ec\u4eab\u6709\u4e34\u5e8a\u8bd5\u9a8c\u8d39\u7528\u7a0e\u6536\u51cf\u514d\u3001\u514d\u9664NDA\u7533\u8bf7\u8d39\u7528\u3001\u83b7\u5f97\u7814\u53d1\u8d44\u52a9\u7b49\uff0c\u7279\u522b\u662f\u8be5\u836f\u7269\u8be5\u9002\u5e94\u75c7\u6279\u51c6\u4e0a\u5e02\u540e\u53ef\u83b7\u5f97\u7f8e\u56fd\u5e02\u573a7\u5e74\u72ec\u5360\u6743\u3002<\/p>\n<p>\u968f\u7740\u4e2d\u56fd\u533b\u836f\u521b\u65b0\u529b\u91cf\u7684\u5d1b\u8d77\uff0c\u4e2d\u56fd\u836f\u4f01\u8fd1\u5e74\u6765\u7684\u201c\u51fa\u6d77\u201d\u8d8b\u52bf\u65e5\u76ca\u660e\u663e\uff0c\u83b7\u5f97FDA\u5b64\u513f\u836f\u8ba4\u5b9a\u7b49\u8d44\u683c\u8ba4\u5b9a\u4e5f\u88ab\u89c6\u4e3a\u91cd\u8981\u7684\u5168\u7403\u5316\u521b\u65b0\u5b9e\u529b\u6307\u6807\u4e4b\u4e00\u3002\u4f5c\u4e3a\u4e00\u76f4\u575a\u6301\u5168\u7403\u521b\u65b0\u7684\u9886\u519b\u4f01\u4e1a\uff0c\u4e9a\u76db\u533b\u836f\u65e0\u7591\u662f\u5176\u4e2d\u4f7c\u4f7c\u8005\u3002\u622a\u81f3\u73b0\u5728\uff0c\u4e9a\u76db\u533b\u836f\u5171\u67094\u4e2a\u5728\u7814\u65b0\u836f\u83b7\u5f979\u9879FDA\u5b64\u513f\u836f\u8ba4\u8bc1\uff08\u89c1\u4e0b\u8868\uff09\u3002\u516c\u5f00\u4fe1\u606f\u663e\u793a\uff0c\u8be5\u6570\u91cf\u5728\u4e2d\u56fd\u4f01\u4e1a\u4e2d\u6700\u4e3a\u9886\u5148\u3002<\/p>\n<div>\n<table cellspacing=\"0\" cellpadding=\"0\" border=\"1\" class=\"prntblns\">\n<tbody>\n<tr>\n<td class=\"prnsbts prnrbrs prnvab prnsbbs prnpl6 prnsbls prnpr6\">\n<p class=\"prnews_p\"><span class=\"prnews_span\"><b>\u836f\u7269<\/b><\/span><\/p>\n<\/td>\n<td class=\"prngen4\">\n<p class=\"prnews_p\"><span class=\"prnews_span\"><b>\u9776\u70b9<\/b><\/span><\/p>\n<\/td>\n<td class=\"prngen4\">\n<p class=\"prnews_p\"><span class=\"prnews_span\"><b>\u9002\u5e94\u75c7<\/b><\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen5\">\n<p class=\"prnews_p\"><span class=\"prnews_span\">HQP1351<\/span><\/p>\n<\/td>\n<td class=\"prngen6\">\n<p class=\"prnews_p\"><span class=\"prnews_span\">BCR-ABL<\/span><\/p>\n<\/td>\n<td class=\"prngen6\">\n<p class=\"prnews_p\"><span class=\"prnews_span\">\u6162\u6027\u9ad3\u7cfb\u767d\u8840\u75c5<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td rowspan=\"4\" class=\"prngen5\">\n<p class=\"prnews_p\"><span class=\"prnews_span\">APG-2575<\/span><\/p>\n<\/td>\n<td rowspan=\"4\" class=\"prngen6\">\n<p class=\"prnews_p\"><span class=\"prnews_span\">Bcl-2<\/span><\/p>\n<\/td>\n<td class=\"prngen6\">\n<p class=\"prnews_p\"><span class=\"prnews_span\">\u534e\u6c0f\u5de8\u7403\u86cb\u767d\u8840\u75c7<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen6\">\n<p class=\"prnews_p\"><span class=\"prnews_span\">\u6162\u6027\u6dcb\u5df4\u7ec6\u80de\u767d\u8840\u75c5<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen6\">\n<p class=\"prnews_p\"><span class=\"prnews_span\">\u591a\u53d1\u6027\u9aa8\u9ad3\u7624<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen6\">\n<p class=\"prnews_p\"><span class=\"prnews_span\">\u6025\u6027\u9ad3\u7cfb\u767d\u8840\u75c5<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td rowspan=\"3\" class=\"prngen5\">\n<p class=\"prnews_p\"><span class=\"prnews_span\">APG-115<\/span><\/p>\n<\/td>\n<td rowspan=\"3\" class=\"prngen6\">\n<p class=\"prnews_p\"><span class=\"prnews_span\">MDM2-p53<\/span><\/p>\n<\/td>\n<td class=\"prngen6\">\n<p class=\"prnews_p\"><span class=\"prnews_span\">\u80c3\u764c<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen6\">\n<p class=\"prnews_p\"><span class=\"prnews_span\">\u6025\u6027\u9ad3\u7cfb\u767d\u8840\u75c5<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen6\">\n<p class=\"prnews_p\"><span class=\"prnews_span\">\u8f6f\u7ec4\u7ec7\u8089\u7624<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen5\">\n<p class=\"prnews_p\"><span class=\"prnews_span\">APG-1252<\/span><\/p>\n<\/td>\n<td class=\"prngen6\">\n<p class=\"prnews_p\"><span class=\"prnews_span\">Bcl-2\/Bcl-xL<\/span><\/p>\n<\/td>\n<td class=\"prngen6\">\n<p class=\"prnews_p\"><span class=\"prnews_span\">\u5c0f\u7ec6\u80de\u80ba\u764c<\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table><\/div>\n<p>FDA\u6279\u51c6\u7684\u521b\u65b0\u836f\u6570\u91cf\u7684\u516c\u5f00\u6570\u636e\u663e\u793a\uff0c\u8fd110\u5e74\u6765\uff0c\u83b7\u5f97FDA\u6279\u51c6\u7684\u5b64\u513f\u836f\u5728\u83b7\u6279\u521b\u65b0\u7597\u6cd5\u4e2d\u7684\u6bd4\u4f8b\u9010\u6b65\u4e0a\u5347\u30022020\u5e74\u5168\u5e74\u83b7\u6279\u65b0\u836f\u4e2d\u83b7\u5b64\u513f\u836f\u8d44\u683c\u7684\u521b\u65b0\u7597\u6cd5\u7684\u6bd4\u4f8b\u8d85\u8fc7\u4e8660%\uff0c\u521b10\u5e74\u6765\u5360\u6bd4\u7684\u65b0\u9ad8\u3002\u8fd9\u4e00\u6570\u636e\u8868\u660e\uff0cFDA\u5b64\u513f\u836f\u8d44\u683c\u8ba4\u5b9a\u7684\u653f\u7b56\u5bf9\u4e8e\u52a0\u5feb\u7f55\u89c1\u75c5\u836f\u7269\u7684\u7814\u53d1\u3001\u4e0a\u5e02\u6709\u7740\u975e\u5e38\u5b9e\u9645\u7684\u6fc0\u52b1\u4e0e\u63a8\u52a8\u610f\u4e49\u3002<\/p>\n<p>\u4e9a\u76db\u533b\u836f\u8463\u4e8b\u957f\u3001CEO\u6768\u5927\u4fca\u535a\u58eb\u8868\u793a\uff1a\u201c\u6211\u4eec\u5728\u77ed\u77ed\u4e00\u5e74\u65f6\u95f4\u5185\uff0c\u83b7\u5f979\u9879FDA\u5b64\u513f\u836f\u8ba4\u8bc1\uff0c\u65e0\u8bba\u5728\u65f6\u95f4\u8fd8\u662f\u6570\u91cf\u4e0a\uff0c\u90fd\u662f\u521b\u4e0b\u4e2d\u56fd\u4f01\u4e1a\u4e4b\u6700\uff0c\u751a\u81f3\u5728\u5168\u7403\u8303\u56f4\u5185\u4e5f\u5e94\u8be5\u662f\u9886\u5148\u7684\u3002\u8fd9\u4e00\u6570\u636e\u7684\u80cc\u540e\uff0c\u6e90\u4e8e\u6211\u4eec\u56e2\u961f\u5bf9\u4e8e\u81ea\u8eab\u4f7f\u547d\u7684\u575a\u5b88\uff0c\u5373\u2018\u89e3\u51b3\u4e2d\u56fd\u4e43\u81f3\u5168\u7403\u60a3\u8005\u5c1a\u672a\u6ee1\u8db3\u7684\u4e34\u5e8a\u9700\u6c42\u2019\u3002\u5e0c\u671b\u5728FDA\u5b64\u513f\u836f\u653f\u7b56\u7684\u63a8\u52a8\u4e0b\uff0c\u6211\u4eec\u7684\u591a\u4e2a\u836f\u7269\u80fd\u52a0\u5feb\u4e34\u5e8a\u5f00\u53d1\u8fdb\u5ea6\uff0c\u65e9\u65e5\u83b7\u6279\uff0c\u4ece\u800c\u66f4\u5feb\u7684\u9020\u798f\u66f4\u591a\u60a3\u8005\u3002\u201d<\/p>\n<p><b>\u53c2\u8003\u6587\u732e<\/b><\/p>\n<div>\n<table id=\"convertedTableb610\" cellspacing=\"0\" cellpadding=\"0\" border=\"0\" class=\"prnsbt0 prnsbr0 prnbcc prnsbb0 prnsbl0\">\n<tbody>\n<tr>\n<td class=\"prnsbtb0 prnrbrb0 prnsbtb0 prnpl6 prnsblb0 prnpr6\">\n<p class=\"prnews_p\"><span class=\"prnews_span\"><i><sup>[1]<\/sup> <\/i><i>DeSantis CE, Lin CC, Mariotto AB, et al. Cancer Treatment and Survivorship Statistics, 2014. CA Cancer J Clin 2014;64:252-271.<\/i><\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table><\/div>\n<p><b>\u5173\u4e8e\u4e9a\u76db\u533b\u836f<\/b><\/p>\n<p>\u4e9a\u76db\u533b\u836f\u662f\u4e00\u5bb6\u7acb\u8db3\u4e2d\u56fd\u3001\u9762\u5411\u5168\u7403\u7684\u5904\u4e8e\u4e34\u5e8a\u5f00\u53d1\u9636\u6bb5\u7684\u539f\u521b\u65b0\u836f\u7814\u53d1\u4f01\u4e1a\uff0c\u81f4\u529b\u4e8e\u5728\u80bf\u7624\u3001\u4e59\u809d\u53ca\u4e0e\u8870\u8001\u76f8\u5173\u7684\u75be\u75c5\u7b49\u6cbb\u7597\u9886\u57df\u5f00\u53d1\u521b\u65b0\u836f\u7269\u30022019\u5e7410\u670828\u65e5\uff0c\u4e9a\u76db\u533b\u836f\u5728\u9999\u6e2f\u8054\u4ea4\u6240\u4e3b\u677f\u6302\u724c\u4e0a\u5e02\uff0c\u80a1\u7968\u4ee3\u7801\uff1a6855.HK\u3002<\/p>\n<p>\u4e9a\u76db\u533b\u836f\u62e5\u6709\u81ea\u4e3b\u6784\u5efa\u7684\u86cb\u767d-\u86cb\u767d\u76f8\u4e92\u4f5c\u7528\u9776\u5411\u836f\u7269\u8bbe\u8ba1\u5e73\u53f0\uff0c\u5904\u4e8e\u7ec6\u80de\u51cb\u4ea1\u901a\u8def\u65b0\u836f\u7814\u53d1\u7684\u5168\u7403\u6700\u524d\u6cbf\u3002\u516c\u53f8\u5df2\u5efa\u7acb\u62e5\u67098\u4e2a\u5df2\u8fdb\u5165\u4e34\u5e8a\u5f00\u53d1\u9636\u6bb5\u76841\u7c7b\u5c0f\u5206\u5b50\u65b0\u836f\u4ea7\u54c1\u7ba1\u7ebf\uff0c\u5305\u62ec\u6291\u5236Bcl-2\u3001IAP \u6216&nbsp;MDM2-p53 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class=\"PRN_ImbeddedAssetReference\" id=\"DivAssetPlaceHolder2\">  <\/div>\n<p>\u76f8\u5173\u94fe\u63a5 :<\/p>\n<blockquote class=\"wp-embedded-content\" data-secret=\"B4CayQPa62\"><p><a href=\"https:\/\/www.ascentagepharma.com\/\">A Leader in the Discovery and Development of Small Molecules that Disrupt Protein-Protein Interactions<\/a><\/p><\/blockquote>\n<p><iframe class=\"wp-embedded-content\" sandbox=\"allow-scripts\" security=\"restricted\" style=\"position: absolute; clip: rect(1px, 1px, 1px, 1px);\" title=\"&#8220;A Leader in the Discovery and Development of Small Molecules that Disrupt Protein-Protein Interactions&#8221; &#8212; Ascentage Pharma\" src=\"https:\/\/www.ascentagepharma.com\/embed\/#?secret=B4CayQPa62\" data-secret=\"B4CayQPa62\" width=\"600\" height=\"338\" frameborder=\"0\" marginwidth=\"0\" marginheight=\"0\" 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\u53c2\u8003\u6587\u732e [1] DeSantis CE, Lin CC, Mariotto AB, et al. Cancer Treatment and Survivorship Statistics, 2014. 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