\u4e0a\u6d772020\u5e7412\u670810\u65e5 \/\u7f8e\u901a\u793e\/ — 2020\u5e7412\u67089\u65e5\uff0c\u5f00\u62d3\u836f\u4e1a\u6709\u9650\u516c\u53f8\uff08\u80a1\u7968\u4ee3\u7801\uff1a9939.HK\uff0c\u4ee5\u4e0b\u7b80\u79f0\uff1a\u201c\u5f00\u62d3\u836f\u4e1a\u201d\uff09\u5ba3\u5e03\uff0c\u5176\u5c06\u57282021\u5e74\u7f8e\u56fd\u4e34\u5e8a\u80bf\u7624\u5b66\u4f1a\u80c3\u80a0\u9053\u80bf\u7624\u7814\u8ba8\u4f1a(ASCO GI)\u4e0a\u901a\u8fc7\u6d77\u62a5(Poster)\u7684\u65b9\u5f0f\uff0c\u516c\u5e03ALK-1\u6297\u4f53GT90001\u8054\u5408PD-1\u6297\u4f53Nivolumab\u4e8c\u7ebf\u6cbb\u7597\u665a\u671f\u809d\u7ec6\u80de\u764c(HCC)\u60a3\u8005II\u671f\u8bd5\u9a8c\u7684\u79ef\u6781\u6570\u636e\u3002\u7ed3\u679c\u663e\u793a\uff0c\u8054\u5408\u7597\u6cd5\u7684\u7597\u6548\u4ee4\u4eba\u9f13\u821e\u4e14\u5b89\u5168\u6027\u826f\u597d\u30022021\u5e74ASCO GI\u5c06\u4e8e\u5f53\u5730\u65f6\u95f42021\u5e741\u670815\u65e5-17\u65e5\u4e3e\u884c\u3002<\/b><\/p>\n
\u25a0 \u6d77\u62a5\u5c55\u793a<\/b> <\/p>\n
\u6458\u8981\u6807\u9898\uff1a<\/b><\/p>\n
Safety and efficacy of combination of GT90001, an anti-activin receptor-like kinase-1(ALK-1) antibody, and nivolumab in patients with metastatic hepatocellular carcinoma (HCC)<\/p>\n
ALK-1\u6297\u4f53(GT90001)\u8054\u5408PD-1\u6297\u4f53(Nivolumab)\u6cbb\u7597\u665a\u671f\u809d\u7ec6\u80de\u764c\uff08HCC\uff09\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027<\/p>\n
\u6458\u8981\u7f16\u53f7\uff1a<\/b>326<\/p>\n
\u7b2c\u4e00\u4f5c\u8005\uff1a<\/b><\/p>\n
\u8bb8\u9a8f\u6559\u6388\uff0c\u533b\u5b66\u535a\u58eb\uff08\u53f0\u6e7e\u5927\u5b66\u533b\u5b66\u9662\u9644\u8bbe\u533b\u9662\uff09<\/p>\n
GT90001\u662f\u4e00\u79cd\u5168\u4eba\u6e90\u5316\u5355\u514b\u9686\u6297\u4f53\uff0c\u53ef\u6291\u5236ALK-1\/ TGF-\u03b2\u4fe1\u53f7\u8f6c\u5bfc\u548c\u80bf\u7624\u8840\u7ba1\u751f\u6210\uff0c\u662f\u5f00\u62d3\u836f\u4e1a\u4e8e2018\u5e74\u81ea\u8f89\u745e\u53d6\u5f97\u72ec\u5bb6\u5168\u7403\u8bb8\u53ef\u7684\u6f5c\u5728\u540c\u7c7b\u9996\u521b\u6297\u4f53\u3002\u8be5\u4e34\u5e8a\u7814\u7a76\uff08NCT03893695\uff09\u4e8e2019\u5e745\u67087\u65e5\u5728\u53f0\u6e7e\u542f\u52a8\uff0c\u65e8\u5728\u8bc4\u4f30GT90001\u8054\u5408Nivolumab\uff08O\u836f\uff09\u5bf9\u4e00\u7ebf\u7d22\u62c9\u975e\u5c3c\u6216\u4ed1\u4f10\u66ff\u5c3c\u6cbb\u7597\u540e\u8fdb\u5c55\u7684\u665a\u671fHCC\u60a3\u8005\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u3002<\/p>\n
\u8fd9\u662f\u4e00\u9879\u5355\u81c2\u3001\u5f00\u653e\u5f0f\u3001\u4e24\u9636\u6bb5\u7684\u4e34\u5e8a\u8bd5\u9a8c\u3002\u8bd5\u9a8c\u4e3b\u8981\u89c2\u5bdf\u8054\u5408\u7597\u6cd5\u7684\u5b89\u5168\u6027\u3001\u8010\u53d7\u6027\u4ee5\u53ca\u6297\u80bf\u7624\u6d3b\u6027\u3002\u7b2c\u4e00\u9636\u6bb5\uff08\u5b89\u5168\u8bc4\u4f30\u961f\u5217\uff09\u4ee5GT90001 \u6bcf2\u54687mg\/kg+Nivolumab\u6bcf2\u54683mg\/kg\u7684\u5242\u91cf\u5165\u7ec46\u4f8b\u53d7\u8bd5\u8005\u3002\u7b2c\u4e8c\u9636\u6bb5\uff08\u6269\u5c55\u961f\u5217\uff09\u5165\u7ec414\u4f8b\u53d7\u8bd5\u8005\u4f7f\u7528\u76f8\u540c\u5242\u91cf\u8fdb\u884c\u8054\u5408\u6cbb\u7597\u3002\u6839\u636eRECIST v1.1\uff0c\u53d7\u8bd5\u8005\u63a5\u53d7\u6cbb\u7597\u76f4\u5230\u5931\u53bb\u4e34\u5e8a\u7597\u6548\u6216\u51fa\u73b0\u4e0d\u53ef\u8010\u53d7\u7684\u6bd2\u6027\uff0c\u4e3b\u8981\u7597\u6548\u7ec8\u70b9\u4e3a\u7814\u7a76\u8005\u8bc4\u4f30\u7684\u5ba2\u89c2\u7f13\u89e3\u7387\uff08ORR\uff09\u3002<\/p>\n
\u7ed3\u679c\u663e\u793a\uff1a2019\u5e747\u67089\u65e5\u81f32020\u5e749\u670830\u65e5\uff0c\u572820\u4f8b\u53ef\u8bc4\u4f30\u7684\u60a3\u8005\u4e2d\uff0c\u67098\u4f8b\uff0840%\uff09\u60a3\u8005\u89c2\u5bdf\u5230\u90e8\u5206\u7f13\u89e3\uff08PR\uff09\uff0c\u4e14\u5b89\u5168\u6027\u826f\u597d\u3002GT90001\u548cNivolumab\u7684\u836f\u4ee3\u52a8\u529b\u5b66\u53c2\u6570\u4e0e\u5355\u836f\u6cbb\u7597\u76f8\u4f3c\u3002<\/p>\n
\u5f00\u62d3\u836f\u4e1a\u521b\u59cb\u4eba\u3001\u8463\u4e8b\u957f\u517c\u9996\u5e2d\u6267\u884c\u5b98\u7ae5\u53cb\u4e4b\u535a\u58eb\u8868\u793a\uff1a\u201c\u516c\u53f8\u5728\u83b7\u5f97GT90001\u5168\u7403\u6743\u5229\u540e\uff0c\u53ca\u65f6\u8c03\u6574\u4e86\u4e34\u5e8a\u5f00\u53d1\u7b56\u7565\uff0c\u91c7\u7528\u4e0e\u514d\u75ab\u7597\u6cd5\u8054\u5408\u7684\u4e34\u5e8a\u65b9\u6848\uff0c\u6211\u4eec\u6b23\u559c\u5730\u89c2\u5bdf\u5230GT90001\u4e0eNivolumab\u7684\u8054\u5408\u7597\u6cd5\u5177\u6709\u826f\u597d\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\uff0c\u7531\u6b64\u6211\u4eec\u5c06\u5728\u4e2d\u56fd\u548c\u7f8e\u56fd\u79ef\u6781\u5e03\u5c40\u5f00\u5c55\u591a\u4e2a\u6cbb\u7597\u665a\u671fHCC\u7684\u56fd\u9645\u591a\u4e2d\u5fc3\u7684II\/III\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u540c\u65f6\u5bf9\u6cbb\u7597\u5176\u5b83\u5b9e\u4f53\u7624\u8fdb\u884c\u63a2\u7d22\uff0c\u4f7f\u66f4\u591a\u80bf\u7624\u60a3\u8005\u53d7\u76ca\u3002\u201d<\/p>\n
\u5173\u4e8eGT90001<\/b><\/p>\n
GT90001\u4e3aALK-1\uff08Activin Receptor-Like Kinase-1\uff0c\u6d3b\u5316\u7d20\u53d7\u4f53\u6837\u6fc0\u9176-1\uff09\u5168\u4eba\u6e90\u5355\u514b\u9686\u6297\u4f53\uff0c\u5f00\u62d3\u836f\u4e1a\u4e8e2018\u5e74\u81ea\u8f89\u745e\u83b7\u5f97\u8be5\u836f\u7269\u5168\u7403\u72ec\u5bb6\u5f00\u53d1\u3001\u751f\u4ea7\u548c\u5546\u4e1a\u5316\u7684\u6743\u5229\u3002ALK-1\u6297\u4f53\u53ef\u901a\u8fc7\u963b\u65adALK-1\u53d7\u4f53\u901a\u8def\u6765\u6291\u5236\u80bf\u7624\u8840\u7ba1\u751f\u957f\u3001\u51cf\u5c11\u8840\u6d41\u53ca\u8840\u7ba1\u751f\u6210\uff0c\u4ece\u800c\u51cf\u7f13\u80bf\u7624\u751f\u957f\uff0c\u4ea6\u53ef\u6539\u53d8\u80bf\u7624\u5fae\u73af\u5883\u3002\u4f5c\u4e3a\u5168\u7403\u6f5c\u5728first-in-class\u521b\u65b0\u836f\u7269\uff0c\u6709\u671b\u7528\u4e8e\u591a\u79cd\u5b9e\u4f53\u80bf\u7624\u7684\u6cbb\u7597\u3002\u8f89\u745e\u5728\u7f8e\u56fd\u3001\u610f\u5927\u5229\u3001\u97e9\u56fd\u4ee5\u53ca\u65e5\u672c\u5bf9GT90001\u5206\u522b\u8fdb\u884c\u4e86\u4e24\u9879I\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u5728\u8d85\u8fc7100\u540d\u665a\u671f\u5b9e\u4f53\u7624\u60a3\u8005\u4e2d\u663e\u793a\u51fa\u826f\u597d\u7684\u5b89\u5168\u6027\u548c\u521d\u6b65\u7684\u6709\u6548\u6027\uff0c\u76ee\u524d\u5f00\u62d3\u836f\u4e1a\u6b63\u5728\u53f0\u6e7e\u8fdb\u884cGT90001\u8054\u5408Nivolumab\uff08PD-1\u6297\u4f53\uff09\u7528\u4e8e\u6cbb\u7597\u665a\u671f\u809d\u764c\u7684II\u671f\u4e34\u5e8a\u8bd5\u9a8c\u3002<\/p>\n
\u5173\u4e8e\u5f00\u62d3\u836f\u4e1a<\/b><\/p>\n
\u5f00\u62d3\u836f\u4e1a\u6210\u7acb\u4e8e2009\u5e74\uff0c\u4e13\u6ce8\u53d1\u5c55\u6f5c\u5728\u201cbest-in-class\u201d\u548c\u201cfirst-in-class\u201d\u521b\u65b0\u836f\u7269\u7684\u7814\u53d1\u53ca\u4ea7\u4e1a\u5316\uff0c\u81f4\u529b\u6210\u4e3a\u521b\u65b0\u7597\u6cd5\u7814\u7a76\u3001\u5f00\u53d1\u53ca\u5546\u4e1a\u5316\u7684\u9886\u519b\u4f01\u4e1a\u3002\u516c\u53f8\u7531\u56fd\u5bb6\u7ea7\u4eba\u624d\u9886\u8854\u521b\u7acb\uff0c\u7ecf\u8fc7\u591a\u5e74\u7684\u53d1\u5c55\uff0c\u4ee5\u96c4\u6fc0\u7d20\u53d7\u4f53(AR)\u76f8\u5173\u75be\u75c5\u4e3a\u6838\u5fc3\uff0c\u7814\u53d1\u591a\u901a\u9053\u4ea7\u54c1\u7ec4\u5408\uff0c\u4ea7\u54c1\u8986\u76d6\u5168\u7403\u9ad8\u53d1\u75c5\u7387\u764c\u75c7\u53ca\u5176\u5b83\u672a\u6ee1\u8db3\u4e34\u5e8a\u9700\u6c42\u7684\u75be\u75c5\u9886\u57df\uff0c\u5305\u62ec\u524d\u5217\u817a\u764c\u3001\u4e73\u817a\u764c\u3001\u809d\u764c\u548c\u8131\u53d1\u7b49\u3002\u5f00\u62d3\u836f\u4e1a\u524d\u77bb\u6027\u5e03\u5c40\u4e86\u5305\u542b\u5c0f\u5206\u5b50\u521b\u65b0\u836f\u3001\u751f\u7269\u521b\u65b0\u836f\u53ca\u8054\u5408\u7597\u6cd5\u7684\u591a\u5143\u5316\u4ea7\u54c1\u7ba1\u7ebf\uff0c\u5305\u62ec5\u6b3e\u6b63\u5728\u5f00\u5c55\u4e34\u5e8a\u7814\u7a76\u7684\u4ea7\u54c1\u96c4\u6fc0\u7d20\u53d7\u4f53(AR)\u62ee\u6297\u5242\u3001ALK-1\u5355\u6297\u3001mTOR\u6fc0\u9176\u9776\u5411\u6291\u5236\u5242\u548cHedgehog\u6291\u5236\u5242\uff0c\u4ee5\u53ca\u6b63\u5728\u8fdb\u884c\u4e34\u5e8a\u524d\u7814\u7a76\u7684PD-L1\/TGF-\u03b2\u53cc\u9776\u70b9\u6297\u4f53\u3001AR-Degrader\u548cc-Myc\u6291\u5236\u5242\u7b49\u3002\u516c\u53f8\u5728\u5168\u7403\u62e5\u6709\u5df2\u83b7\u5f97\u53ca\u7533\u8bf7\u4e2d\u768460\u591a\u9879\u4e13\u5229\uff0c\u591a\u4e2a\u9879\u76ee\u88ab\u5217\u4e3a\u56fd\u5bb6\u5341\u4e8c\u4e94\u3001\u5341\u4e09\u4e94\u201c\u91cd\u5927\u65b0\u836f\u521b\u5236\u201d\u4e13\u9879\u30022020\u5e745\u670822\u65e5\uff0c\u5f00\u62d3\u836f\u4e1a\u6b63\u5f0f\u5728\u9999\u6e2f\u8054\u5408\u4ea4\u6613\u6240\u6709\u9650\u516c\u53f8\u4e3b\u677f\u6302\u724c\u4e0a\u5e02\uff0c\u80a1\u7968\u4ee3\u7801\uff1a9939.HK\u3002\u6b22\u8fce\u8bbf\u95ee\u516c\u53f8\u7f51\u7ad9\uff1awww.kintor.com.cn<\/a>\u3002 <\/p>\n \u76f8\u5173\u94fe\u63a5 :<\/p>\n http:\/\/www.kintor.com.cn<\/p>\n","protected":false},"excerpt":{"rendered":" \u4e0a\u6d772020\u5e7412\u670810\u65e5 \/\u7f8e\u901a\u793e\/ — 2020\u5e7412\u67089\u65e5\uff0c\u5f00\u62d3\u836f\u4e1a\u6709\u9650\u516c\u53f8\uff08\u80a1\u7968\u4ee3\u7801\uff1a9939.HK\uff0c\u4ee5\u4e0b\u7b80\u79f0\uff1a\u201c\u5f00\u62d3\u836f\u4e1a\u201d\uff09\u5ba3\u5e03\uff0c\u5176\u5c06\u57282021\u5e74\u7f8e\u56fd\u4e34\u5e8a\u80bf\u7624\u5b66\u4f1a\u80c3\u80a0\u9053\u80bf\u7624\u7814\u8ba8\u4f1a(ASCO GI)\u4e0a\u901a\u8fc7\u6d77\u62a5(Poster)\u7684\u65b9\u5f0f\uff0c\u516c\u5e03ALK-1\u6297\u4f53GT90001\u8054\u5408PD-1\u6297\u4f53Nivolumab\u4e8c\u7ebf\u6cbb\u7597\u665a\u671f\u809d\u7ec6\u80de\u764c(HCC)\u60a3\u8005II\u671f\u8bd5\u9a8c\u7684\u79ef\u6781\u6570\u636e\u3002\u7ed3\u679c\u663e\u793a\uff0c\u8054\u5408\u7597\u6cd5\u7684\u7597\u6548\u4ee4\u4eba\u9f13\u821e\u4e14\u5b89\u5168\u6027\u826f\u597d\u30022021\u5e74ASCO 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