{"id":13454,"date":"2020-12-09T11:57:00","date_gmt":"2020-12-09T04:57:00","guid":{"rendered":"https:\/\/www.xinwengao.com\/cn\/pr\/2020120911570013454"},"modified":"2020-12-10T09:16:53","modified_gmt":"2020-12-10T01:16:53","slug":"%e6%8b%9c%e8%80%b3%e4%b8%8eatara%e5%85%ac%e5%8f%b8%e5%bb%ba%e7%ab%8b%e6%88%98%e7%95%a5%e5%90%88%e4%bd%9c%ef%bc%8c%e5%bc%80%e5%8f%91%e4%b8%8b%e4%b8%80%e4%bb%a3%e9%97%b4%e7%9a%ae%e7%b4%a0%e9%9d%b6","status":"publish","type":"post","link":"https:\/\/www.xinwengao.com\/cn\/pr\/2020120911570013454","title":{"rendered":"\u62dc\u8033\u4e0eAtara\u516c\u53f8\u5efa\u7acb\u6218\u7565\u5408\u4f5c\uff0c\u5f00\u53d1\u4e0b\u4e00\u4ee3\u95f4\u76ae\u7d20\u9776\u5411CAR-T\u7ec6\u80de\u7597\u6cd5"},"content":{"rendered":"<ul type=\"disc\">\n<li>\u8be5\u534f\u8bae\u662f\u62dc\u8033\u5168\u65b0\u7ec6\u80de\u4e0e\u57fa\u56e0\u6cbb\u7597\u6218\u7565\u7684\u5173\u952e\u7ec4\u6210\u8981\u7d20 <\/li>\n<li>\u62dc\u8033\u5c06\u8fdb\u5165CAR-T\u7ec6\u80de\u6cbb\u7597\u9886\u57df\uff0c\u901a\u8fc7\u5f00\u521b\u6027\u6280\u672f\u6269\u5c55\u80bf\u7624\u7814\u53d1\u4ea7\u54c1\u7ebf <\/li>\n<li>\u8fd9\u662f\u5bf9Atara\u6280\u672f\u5e73\u53f0\u5728\u540c\u79cd\u5f02\u4f53\u7ec6\u80de\u6cbb\u7597\u9886\u57df\u9886\u5148\u5730\u4f4d\u7684\u8ba4\u53ef <\/li>\n<li>\u5408\u4f5c\u5c06\u5173\u6ce8\u4e0b\u4e00\u4ee3\u53ef\u666e\u53ca\u7684T\u7ec6\u80de\u514d\u75ab\u7597\u6cd5ATA3271\uff0c\u7528\u4e8e\u6cbb\u7597\u5b58\u5728\u95f4\u76ae\u7d20\u9ad8\u8868\u8fbe\u7684\u80bf\u7624 <\/li>\n<li>Atara\u516c\u53f8\u5c06\u6536\u52306,000\u4e07\u7f8e\u5143\u7684\u9884\u4ed8\u6b3e\uff0c\u548c\u57fa\u4e8e\u5f00\u53d1\u3001\u6ce8\u518c\u4e0e\u5546\u4e1a\u5316\u8fdb\u5c55\u7684\u6700\u9ad8\u53ef\u8fbe6.1\u4ebf\u7f8e\u5143\u7684\u91cc\u7a0b\u7891\u4ed8\u6b3e\uff0c\u4ee5\u53ca\u6700\u9ad8\u53ef\u8fbe\u51c0\u9500\u552e\u989d\u4f4e\u4e24\u4f4d\u6570\u767e\u5206\u6bd4\u7684\u5206\u5c42\u63d0\u6210 <\/li>\n<\/ul>\n<p><p>\u67cf\u6797\u548c\u52a0\u5229\u798f\u5c3c\u4e9a\u5dde\u5357\u65e7\u91d1\u5c712020\u5e7412\u6708<span id=\"spanHghltfb5f\">9<\/span>\u65e5 \/\u7f8e\u901a\u793e\/ &#8212; \u62dc\u8033\u4e0eAtara\u751f\u7269\u533b\u836f\u516c\u53f8<span id=\"spanHghltffcb\">\u4e8e2020\u5e7412\u67087\u65e5<\/span>\u5ba3\u5e03\u53cc\u65b9\u8fbe\u6210\u4e00\u9879\u72ec\u5bb6\u5168\u7403\u8bb8\u53ef\u534f\u8bae\uff0c\u5171\u540c\u5f00\u53d1\u7528\u4e8e\u6cbb\u7597\u5b9e\u4f53\u7624\u7684\u4e0b\u4e00\u4ee3\u95f4\u76ae\u7d20\u5bfc\u5411CAR-T\u7ec6\u80de\u7597\u6cd5\u3002\u8be5\u534f\u8bae\u5305\u62ec\u5f00\u53d1\u5019\u9009\u836f\u7269ATA3271\uff08\u4e00\u79cd\u589e\u5f3a\u578b\u4e0b\u4e00\u4ee3\u540c\u79cd\u5f02\u4f53T\u7ec6\u80de\u514d\u75ab\u7597\u6cd5\uff09\u4ee5\u53ca\u81ea\u4f53\u7248\u672c\u7684ATA2271\uff0c\u7528\u4e8e\u6cbb\u7597\u5b58\u5728\u95f4\u76ae\u7d20\u9ad8\u8868\u8fbe\u7684\u80bf\u7624\uff0c\u4f8b\u5982\u6076\u6027\u80f8\u819c\u95f4\u76ae\u7624\u4ee5\u53ca\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u3002<\/p>\n<p>Atara\u516c\u53f8\u662f\u540c\u79cd\u5f02\u4f53T\u7ec6\u80de\u514d\u75ab\u7597\u6cd5\u9886\u57df\u7684\u5148\u884c\u8005\uff0c\u62e5\u6709\u884c\u4e1a\u9886\u5148\u7684\u540c\u79cd\u5f02\u4f53\u7ec6\u80de\u5236\u9020\u5de5\u827a\u548c\u4e0b\u4e00\u4ee3CAR-T\u6280\u672f\u3002\u6b64\u6b21\u8bb8\u53ef\u7684\u6280\u672f\u5229\u7528\u4e86Atara\u65b0\u578b\u7684\u4e13\u6709\u7231\u6cfc\u65af\u5766-\u5df4\u5c14\u75c5\u6bd2\uff08EBV\uff09T\u7ec6\u80de\u5e73\u53f0\uff0c\u5e76\u7ed3\u5408\u9488\u5bf9\u95f4\u76ae\u7d20\u7684\u4e0b\u4e00\u4ee3CAR-T\u6280\u672f\uff0c\u4ece\u800c\u63d0\u9ad8\u7597\u6548\uff0c\u6301\u4e45\u6027\uff0c\u5b89\u5168\u6027\u548c\u54cd\u5e94\u8010\u4e45\u6027\u3002<\/p>\n<p>\u62dc\u8033\u7ec6\u80de\u4e0e\u57fa\u56e0\u6cbb\u7597\u5e73\u53f0\u8d1f\u8d23\u4ebaWolfram Carius\u8868\u793a\uff1a\u201c\u8fd9\u9879\u4ea4\u6613\u662f\u62dc\u8033\u5168\u65b0\u7ec6\u80de\u4e0e\u57fa\u56e0\u6cbb\u7597\u6218\u7565\u7684\u5173\u952e\u7ec4\u6210\u8981\u7d20\u3002\u516c\u53f8\u7684\u5f00\u53d1\u4ea7\u54c1\u7ec4\u5408\u901a\u8fc7\u540c\u79cd\u5f02\u4f53\u7ec6\u80de\u7597\u6cd5\u5f97\u5230\u4e86\u52a0\u5f3a\uff0c\u8fd9\u4e5f\u5de9\u56fa\u4e86\u6211\u4eec\u5728\u8be5\u9886\u57df\u5df2\u521d\u6b65\u5efa\u7acb\u7684\u9886\u5bfc\u5730\u4f4d\u3002\u6211\u4eec\u671f\u5f85\u4e0eAtara\u5408\u4f5c\uff0c\u4e3a\u8eab\u60a3\u96be\u4ee5\u6cbb\u7597\u7c7b\u578b\u764c\u75c7\u7684\u60a3\u8005\u5f00\u53d1\u4e0b\u4e00\u4ee3\u53ef\u666e\u53ca\u7684CAR-T\u7ec6\u80de\u7597\u6cd5\u3002\u201d <\/p>\n<p>Atara\u516c\u53f8\u603b\u88c1\u517c\u9996\u5e2d\u6267\u884c\u5b98Pascal Touchon\u8868\u793a\uff1a\u201c\u6b64\u6b21Atara\u4e0e\u62dc\u8033\u8fbe\u6210\u7684\u5408\u4f5c\u4ee4\u4eba\u5174\u594b\uff0c\u8fd9\u5c06\u52a0\u901f\u5f00\u53d1\u7528\u4e8e\u6cbb\u7597\u591a\u79cd\u7c7b\u578b\u5b9e\u4f53\u7624\u7684\u4e0b\u4e00\u4ee3\u95f4\u76ae\u7d20\u9776\u5411CAR-T\u7ec6\u80de\u7597\u6cd5\uff0c\u5e2e\u52a9\u6211\u4eec\u5229\u7528\u540c\u79cd\u5f02\u4f53\u7ec6\u80de\u6cbb\u7597\u5e73\u53f0\u7684\u80fd\u529b\u5c3d\u5feb\u9020\u798f\u60a3\u8005\u3002\u62dc\u8033\u5728\u80bf\u7624\u9886\u57df\u5168\u7403\u5f00\u53d1\u548c\u5546\u4e1a\u5316\u65b9\u9762\u53d6\u5f97\u7684\u4f18\u5f02\u6210\u7ee9\u4ee5\u53ca\u5728\u7ec6\u80de\u548c\u57fa\u56e0\u6cbb\u7597\u9886\u57df\u7684\u53d1\u5c55\u5b9e\u529b\uff0c\u5c06\u63d0\u5347Atara\u7684\u80fd\u529b\uff0c\u5e76\u6709\u529b\u8865\u5145\u6211\u4eec\u9886\u5148\u7684\u540c\u79cd\u5f02\u4f53T\u7ec6\u80de\u5e73\u53f0\u3002\u201d<\/p>\n<p>\u6839\u636e\u534f\u8bae\u6761\u6b3e\uff0cAtara \u5c06\u8d1f\u8d23ATA3271\u7684\u4e34\u5e8a\u7814\u7a76\u7533\u8bf7\uff08IND\uff09\u76f8\u5173\u7814\u7a76\u4ee5\u53ca\u5de5\u827a\u5f00\u53d1\uff0c\u62dc\u8033\u5c06\u8d1f\u8d23\u63d0\u4ea4IND\u4ee5\u53ca\u540e\u7eed\u4e34\u5e8a\u5f00\u53d1\u548c\u5546\u4e1a\u5316\u5de5\u4f5c\u3002\u6b64\u5916\uff0cAtara\u8fd8\u5c06\u7ee7\u7eed\u8d1f\u8d23ATA2711\u6b63\u5728\u8fdb\u884c\u4e2d\u7684I\u671f\u7814\u7a76\uff0c\u5176IND\u63d0\u4ea4\u5df2\u88ab\u63a5\u53d7\u4e14\u4e34\u5e8a\u7814\u7a76\u5df2\u542f\u52a8\u3002Atara\u5c06\u83b7\u5f976,000\u4e07\u7f8e\u5143\u7684\u9884\u4ed8\u6b3e\uff0c\u5e76\u4e14\u6709\u8d44\u683c\u6839\u636e\u5f00\u53d1\u3001\u6ce8\u518c\u53ca\u5546\u4e1a\u5316\u7684\u67d0\u4e9b\u7279\u5b9a\u91cc\u7a0b\u7891\u4e8b\u4ef6\u83b7\u5f97\u603b\u8ba1\u6700\u9ad8\u53ef\u8fbe6.1\u4ebf\u7f8e\u5143\u7684\u4ed8\u6b3e\uff0c\u4ee5\u53ca\u6700\u9ad8\u53ef\u8fbe\u51c0\u9500\u552e\u989d\u4f4e\u4e24\u4f4d\u6570\u767e\u5206\u6bd4\u7684\u5206\u5c42\u63d0\u6210\u3002<\/p>\n<p>\u4f5c\u4e3a\u6b64\u4ea4\u6613\u7684\u4e00\u90e8\u5206\uff0cAtara\u8fd8\u5c06\u63d0\u4f9b\u8f6c\u5316\u53ca\u4e34\u5e8a\u751f\u4ea7\u670d\u52a1\uff0c\u62dc\u8033\u5c06\u652f\u4ed8\u76f8\u5173\u8d39\u7528\u3002\u6b64\u5916\uff0c\u62dc\u8033\u5728\u4e00\u5b9a\u671f\u9650\u5185\u8fd8\u4eab\u6709\u975e\u72ec\u5bb6\u6743\u5229\uff0c\u53ef\u5c31Atara\u5176\u4ed6CAR-T\u5019\u9009\u4ea7\u54c1\u7684\u8bb8\u53ef\u8fdb\u884c\u8c08\u5224\u3002<\/p>\n<p><b>\u5173\u4e8e<\/b><b>CAR-T<\/b><b>\u7ec6\u80de\u7597\u6cd5<\/b><\/p>\n<p>T\u7ec6\u80de\u662f\u767d\u7ec6\u80de\u7684\u4e00\u79cd\uff0c\u5bf9\u4e8e\u6e05\u9664\u5065\u5eb7\u4eba\u4f53\u5185\u7684\u5f02\u5e38\u7ec6\u80de\u548c\u764c\u7ec6\u80de\u81f3\u5173\u91cd\u8981\u3002\u5728\u764c\u75c7\u60a3\u8005\u4e2d\uff0c\u8fd9\u4e9bT\u7ec6\u80de\u7ecf\u5e38\u65e0\u6cd5\u8bc6\u522b\u6216\u6709\u6548\u5730\u4e0e\u764c\u7ec6\u80de\u76f8\u7ed3\u5408\u3002CAR-T\u7ec6\u80de\u7597\u6cd5\u901a\u8fc7\u5de5\u7a0b\u6539\u9020\u4eba\u7c7bT\u7ec6\u80de\u6765\u8868\u8fbe\u5d4c\u5408\u6297\u539f\u53d7\u4f53\uff08CAR\uff09\uff0c\u4ece\u800c\u63d0\u9ad8\u5176\u8bc6\u522b\u764c\u75c7\u7ec6\u80de\u7684\u80fd\u529b\u3002\u8fd9\u4e9b\u7597\u6cd5\u5229\u7528\u514d\u75ab\u7cfb\u7edf\u5bf9\u6297\u764c\u75c7\uff0c\u6709\u6f5c\u529b\u4e3a\u764c\u75c7\u6cbb\u7597\u5e26\u6765\u98a0\u8986\u6027\u7684\u6cbb\u7597\u624b\u6bb5\uff0c\u751a\u81f3\u662f\u6cbb\u6108\u7684\u53ef\u80fd\u3002\u95f4\u76ae\u7d20\u662f\u4e00\u79cd\u80bf\u7624\u7279\u5f02\u6027\u6297\u539f\uff0c\u901a\u5e38\u5728\u8bb8\u591a\u4fb5\u88ad\u6027\u5b9e\u4f53\u7624\u7ec6\u80de\u8868\u9762\u9ad8\u5ea6\u8868\u8fbe\uff0c\u662f\u5728\u5305\u62ecCAR-T\u7597\u6cd5\u5728\u5185\u7684\u514d\u75ab\u6cbb\u7597\u9886\u57df\u4e2d\u5907\u53d7\u5173\u6ce8\u7684\u4e00\u4e2a\u9776\u70b9\u3002<\/p>\n<p><b>\u5173\u4e8e\u62dc\u8033\u65b0\u7684\u7ec6\u80de\u4e0e\u57fa\u56e0\u6cbb\u7597\uff08<\/b><b>C&amp;GT<\/b><b>\uff09\u5e73\u53f0<\/b><\/p>\n<p>\u4e3a\u6269\u5c55\u5728\u7ec6\u80de\u4e0e\u57fa\u56e0\u6cbb\u7597\u9886\u57df\u7684\u5b9e\u529b\uff0c\u62dc\u8033\u6b63\u5728\u52a0\u5f3a\u516c\u53f8\u5185\u90e8\u76f8\u5173\u80fd\u529b\uff0c\u540c\u65f6\u4e5f\u5728\u5bfb\u6c42\u5916\u90e8\u6218\u7565\u5408\u4f5c\uff0c\u6280\u672f\u6536\u8d2d\u4ee5\u53ca\u8bb8\u53ef\u4ea4\u6613\uff0c\u5176\u76ee\u6807\u662f\u5efa\u7acb\u5f3a\u5927\u7684\u5e73\u53f0\uff0c\u62e5\u6709\u8de8\u4e0d\u540c\u6cbb\u7597\u9886\u57df\u7684\u5e7f\u6cdb\u5e94\u7528\u3002\u4ece\u6218\u7565\u5c42\u9762\u800c\u8a00\uff0c\u62dc\u8033\u5173\u6ce8\u7ec6\u80de\u4e0e\u57fa\u56e0\u6cbb\u7597\u7684\u7279\u5b9a\u9886\u57df\uff0c\u4f8b\u5982\uff0c\u5e94\u7528\u4e8e\u4e0d\u540c\u9002\u5e94\u75c7\u7684\u5e72\u7ec6\u80de\u7597\u6cd5\uff08\u805a\u7126\u5728\u8bf1\u5bfc\u6027\u591a\u529f\u80fd\u5e72\u7ec6\u80de\u6216\u79f0\u4e3aiPSCs\uff09\uff0c\u57fa\u56e0\u589e\u5f3a\uff0c\u57fa\u56e0\u7f16\u8f91\u4ee5\u53ca\u540c\u79cd\u5f02\u4f53\u7ec6\u80de\u7597\u6cd5\u3002\u5c06\u5916\u90e8\u521b\u65b0\u4e0e\u62dc\u8033\u56e2\u961f\u7684\u81ea\u8eab\u4e13\u957f\u76f8\u7ed3\u5408\u662f\u4e00\u9879\u5173\u952e\u7684\u4ef7\u503c\u9a71\u52a8\u529b\uff0c\u7279\u522b\u662f\u5728\u7ec6\u80de\u4e0e\u57fa\u56e0\u6cbb\u7597\u8fd9\u4e2a\u9ad8\u901f\u53d1\u5c55\u4e14\u7ade\u4e89\u6fc0\u70c8\u7684\u9886\u57df\u3002\u5728\u62dc\u8033\u7ec6\u80de\u4e0e\u57fa\u56e0\u6cbb\u7597\u5e73\u53f0\u7684\u8fd0\u8425\u6a21\u5f0f\u4e0b\uff0c\u5408\u4f5c\u4f19\u4f34\u5c06\u53ef\u4ee5\u81ea\u4e3b\u8fd0\u8425\uff0c\u5168\u9762\u8d1f\u8d23\u5f00\u53d1\u5e76\u63a8\u8fdb\u4ed6\u4eec\u7684\u4ea7\u54c1\u7ec4\u5408\u53ca\u6280\u672f\uff0c\u8fd9\u5bf9\u4e8e\u4fdd\u7559\u5176\u521b\u4e1a\u6587\u5316\u5e76\u5c06\u62dc\u8033\u4f5c\u4e3a\u9996\u9009\u5408\u4f5c\u4f19\u4f34\u7684\u5b9a\u4f4d\u800c\u8a00\u81f3\u5173\u91cd\u8981\u3002\u62dc\u8033\u7ec6\u80de\u4e0e\u57fa\u56e0\u6cbb\u7597\u5e73\u53f0\u7684\u89d2\u8272\u662f\u8fdb\u884c\u6218\u7565\u6307\u5bfc\uff0c\u786e\u4fdd\u4e0b\u5c5e\u5404\u7ec4\u6210\u90e8\u95e8\u80fd\u6709\u6548\u4e92\u8865\uff0c\u5c06\u6700\u597d\u7684\u751f\u7269\u79d1\u6280\u4e0e\u5236\u836f\u4e13\u957f\u6709\u673a\u7ed3\u5408\u3002\u4f5c\u4e3a\u62dc\u8033\u5904\u65b9\u836f\u4e8b\u4e1a\u90e8\u7684\u7ec4\u6210\u90e8\u5206\uff0c\u7ec6\u80de\u4e0e\u57fa\u56e0\u6cbb\u7597\u5e73\u53f0\u5c06\u7ed3\u5408\u591a\u9879\u91cd\u8981\u804c\u80fd\uff0c\u4e3a\u7ec6\u80de\u548c\u57fa\u56e0\u7597\u6cd5\u7814\u7a76\u4e0e\u5f00\u53d1\u5de5\u4f5c\u7684\u6574\u4e2a\u4ef7\u503c\u94fe\u63d0\u4f9b\u652f\u6301\uff0c\u5305\u62ec\u5728\u7814\u7a76\u4e0e\u4e34\u5e8a\u524d\u5f00\u53d1\uff0c\u5316\u5b66\u3001\u5236\u9020\u548c\u63a7\u5236\uff08CMC\uff09\uff0c\u4e34\u5e8a\u5f00\u53d1\uff0c\u5546\u4e1a\u5316\uff0c\u6218\u7565\u5b9e\u65bd\u4ee5\u53ca\u9879\u76ee\u7ba1\u7406\u7b49\u65b9\u9762\u7684\u76f8\u5173\u4e13\u4e1a\u77e5\u8bc6\u3002\u51ed\u501f\u9ad8\u5ea6\u7075\u6d3b\u6027\uff0c\u8be5\u5e73\u53f0\u5c06\u534f\u8c03\u4ece\u79d1\u5b66\u7814\u7a76\u5230\u4ea7\u54c1\u4e0a\u5e02\u7684\u5404\u9879\u8fd0\u8425\u5de5\u4f5c\uff0c\u81f4\u529b\u4e8e\u6253\u9020\u5e76\u4fdd\u6301\u53ef\u6301\u7eed\u7684\u7814\u53d1\u4ea7\u54c1\u7ebf\uff0c\u5c3d\u5feb\u5c06\u7a81\u7834\u6027\u79d1\u5b66\u6210\u679c\u63a8\u5411\u5e02\u573a\u3002<\/p>\n<p><b>\u5173\u4e8e\u62dc\u8033<\/b><\/p>\n<p>\u62dc\u8033\u4f5c\u4e3a\u4e00\u5bb6\u8de8\u56fd\u516c\u53f8\uff0c\u5728\u751f\u547d\u79d1\u5b66\u9886\u57df\u7684\u5065\u5eb7\u4e0e\u8425\u517b\u65b9\u9762\u5177\u6709\u6838\u5fc3\u7ade\u4e89\u529b\u3002\u516c\u53f8\u81f4\u529b\u4e8e\u901a\u8fc7\u4ea7\u54c1\u548c\u670d\u52a1\uff0c\u5e2e\u52a9\u4eba\u4eec\u514b\u670d\u5168\u7403\u4eba\u53e3\u4e0d\u65ad\u589e\u957f\u548c\u8001\u9f84\u5316\u5e26\u6765\u7684\u91cd\u5927\u6311\u6218\uff0c\u9020\u798f\u4eba\u7c7b\u3002\u540c\u65f6\uff0c\u96c6\u56e2\u8fd8\u901a\u8fc7\u79d1\u6280\u521b\u65b0\u548c\u4e1a\u52a1\u589e\u957f\u6765\u63d0\u5347\u76c8\u5229\u80fd\u529b\u5e76\u521b\u9020\u4ef7\u503c\u3002\u62dc\u8033\u81f4\u529b\u4e8e\u53ef\u6301\u7eed\u53d1\u5c55\u3002\u5728\u5168\u7403\uff0c\u62dc\u8033\u54c1\u724c\u4ee3\u8868\u7740\u53ef\u4fe1\u3001\u53ef\u9760\u53ca\u4f18\u8d28\u3002\u57282019\u8d22\u5e74\uff0c\u62dc\u8033\u7684\u5458\u5de5\u4eba\u6570\u7ea6\u4e3a104,000\u540d\uff0c\u9500\u552e\u989d\u4e3a435\u4ebf\u6b27\u5143\uff0c\u8d44\u672c\u652f\u51fa\u4e3a29\u4ebf\u6b27\u5143\uff0c\u7814\u7a76\u5f00\u53d1\u6295\u5165\u4e3a53\u4ebf\u6b27\u5143\u3002\u66f4\u591a\u4fe1\u606f\u8bf7\u89c1<a target=\"_blank\" href=\"http:\/\/www.bayer.com\/\" rel=\"nofollow noopener noreferrer\">www.bayer.com<\/a>\u3002 <\/p>\n<p><b>\u5173\u4e8e<\/b><b>Atara<\/b><\/p>\n<p>Atara \u751f\u7269\u533b\u836f\u516c\u53f8\uff08Atara Biotherapeutics, Inc.\uff09\u4f5c\u4e3aT\u7ec6\u80de\u514d\u75ab\u7597\u6cd5\u9886\u57df\u7684\u5148\u884c\u8005\uff0c\u5229\u7528\u5176\u65b0\u578b\u7684\u540c\u79cd\u5f02\u4f53EBV T\u7ec6\u80de\u5e73\u53f0\u4e3a\u8eab\u60a3\u4e25\u91cd\u75be\u75c5\uff08\u5305\u62ec\u5b9e\u4f53\u7624\uff0c\u8840\u6db2\u80bf\u7624\u548c\u81ea\u8eab\u514d\u75ab\u6027\u75be\u75c5\uff09\u7684\u60a3\u8005\u5f00\u53d1\u53d8\u9769\u6027\u7684\u7597\u6cd5\u3002\u51ed\u501f\u6211\u4eec\u5728III\u671f\u4e34\u5e8a\u5f00\u53d1\u4e2d\u7684\u9886\u5148\u9879\u76ee\uff0cAtara<span id=\"spanHghltc87f\">\u662f\u9886\u5148<\/span>\u7684\u540c\u79cd\u5f02\u4f53T\u7ec6\u80de\u514d\u75ab\u7597\u6cd5\u516c\u53f8\uff0c\u65e8\u5728\u4e3a\u5b58\u5728\u9ad8\u5ea6\u672a\u6ee1\u8db3\u533b\u7597\u9700\u6c42\u7684\u60a3\u8005\u5feb\u901f\u63d0\u4f9b\u53ef\u7528\u7684\u6cbb\u7597\u65b9\u6cd5\u3002\u6211\u4eec\u7684\u5e73\u53f0\u5229\u7528\u4e86EBV T\u7ec6\u80de\u7684\u72ec\u7279\u751f\u7269\u5b66\u7279\u6027\uff0c\u901a\u8fc7\u6574\u5408\u5de5\u7a0b\u5316\u7684CAR\uff08\u5d4c\u5408\u6297\u539f\u53d7\u4f53\uff09\u6216TCR\uff08T\u7ec6\u80de\u53d7\u4f53\uff09\uff0c\u62e5\u6709\u6cbb\u7597\u4f17\u591a\u4e0eEBV\u76f8\u5173\u7684\u75be\u75c5\u6216\u5176\u4ed6\u4e25\u91cd\u75be\u75c5\u7684\u80fd\u529b\u3002Atara\u6b63\u5229\u7528\u8fd9\u4e00\u5e73\u53f0\u521b\u9020\u5f3a\u5927\u7684\u7814\u53d1\u4ea7\u54c1\u7ebf\uff0c\u5176\u4e2d\u5305\u62ec\uff1a\u5904\u4e8eIII\u671f\u4e34\u5e8a\u5f00\u53d1\u9636\u6bb5\u7684tab-cel<sup>&reg;<\/sup>\uff08tabelecleucel\uff09\uff0c\u7528\u4e8e\u6cbb\u7597\u7231\u6cfc\u65af\u5766-\u5df4\u5c14\u75c5\u6bd2\u9a71\u52a8\u7684\u79fb\u690d\u540e\u6dcb\u5df4\u589e\u751f\u6027\u75be\u75c5\uff08EBV + PTLD\uff09\uff1bATA188\uff08\u4e00\u79cd\u9488\u5bf9EBV\u6297\u539f\u7684T\u7ec6\u80de\u514d\u75ab\u7597\u6cd5\uff09\uff0c\u53ef\u4f5c\u4e3a\u591a\u53d1\u6027\u786c\u5316\u75c7\u7684\u4e00\u79cd\u6f5c\u5728\u6cbb\u7597\u65b9\u6848\uff1b\u4ee5\u53ca\u591a\u79cd\u9488\u5bf9\u5b9e\u4f53\u7624\u548c\u8840\u6db2\u7cfb\u7edf\u6076\u6027\u80bf\u7624\u7684\u4e0b\u4e00\u4ee3\u5d4c\u5408\u6297\u539f\u53d7\u4f53T\u7ec6\u80de\uff08CAR-T\uff09\u514d\u75ab\u7597\u6cd5\u3002\u6539\u5584\u60a3\u8005\u7684\u751f\u6d3b\u662f\u6211\u4eec\u516c\u53f8\u7684\u4f7f\u547d\uff0c\u6211\u4eec\u5c06\u6301\u7eed\u4e0d\u65ad\u5730\u4e3a\u9700\u8981\u5e2e\u52a9\u7684\u4eba\u4eec\u5e26\u6765\u53d8\u9769\u6027\u5730\u7597\u6cd5\u3002&nbsp;Atara\u516c\u53f8\u7684\u603b\u90e8\u4f4d\u4e8e\u5357\u65e7\u91d1\u5c71\uff0c\u5e76\u5728\u52a0\u5229\u798f\u5c3c\u4e9a\u5dde\u5343\u6a61\u5e02\u8bbe\u7acb\u4e86\u9886\u5148\u7684\u7814\u53d1\u673a\u6784\u53ca\u751f\u4ea7\u5de5\u5382\u3002<\/p>\n<p><b>\u524d\u77bb\u6027\u58f0\u660e<\/b><\/p>\n<p>\u672c\u65b0\u95fb\u7a3f\u5305\u62ec\u62dc\u8033\u96c6\u56e2\u7ba1\u7406\u5c42\u57fa\u4e8e\u5f53\u524d\u8bbe\u60f3\u548c\u9884\u6d4b\u6240\u4f5c\u7684\u524d\u77bb\u6027\u58f0\u660e\u3002\u5404\u79cd\u5df2\u77e5\u548c\u672a\u77e5\u7684\u98ce\u9669\u3001\u4e0d\u786e\u5b9a\u6027\u548c\u5176\u5b83\u56e0\u7d20\u5747\u53ef\u80fd\u5bfc\u81f4\u516c\u53f8\u672a\u6765\u7684\u5b9e\u9645\u8fd0\u8425\u7ed3\u679c\u3001\u8d22\u52a1\u72b6\u51b5\u3001\u53d1\u5c55\u6216\u4e1a\u7ee9\u4e0e\u4e0a\u8ff0\u524d\u77bb\u6027\u8868\u8ff0\u4e2d\u6240\u4f5c\u51fa\u7684\u4f30\u8ba1\u4ea7\u751f\u91cd\u5927\u5dee\u5f02\u3002\u8fd9\u4e9b\u56e0\u7d20\u5305\u62ec\u5728\u62dc\u8033\u5b98\u65b9\u7f51\u7ad9<a target=\"_blank\" href=\"http:\/\/www.bayer.com\/\" rel=\"nofollow noopener noreferrer\">http:\/\/www.bayer.com\/<\/a> \u4e0a\u516c\u5f00\u7684\u62dc\u8033\u5404\u9879\u62a5\u544a\u3002\u672c\u516c\u53f8\u6ca1\u6709\u8d23\u4efb\u66f4\u65b0\u8fd9\u4e9b\u524d\u77bb\u6027\u58f0\u660e\u6216\u4f7f\u5176\u7b26\u5408\u672a\u6765\u53d1\u751f\u7684\u4e8b\u4ef6\u6216\u53d1\u5c55\u3002<\/p>\n<p>\u76f8\u5173\u94fe\u63a5 :<\/p>\n<p>http:\/\/www.bayer.com<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u8be5\u534f\u8bae\u662f\u62dc\u8033\u5168\u65b0\u7ec6\u80de\u4e0e\u57fa\u56e0\u6cbb\u7597\u6218\u7565\u7684\u5173\u952e\u7ec4\u6210\u8981\u7d20 \u62dc\u8033\u5c06\u8fdb\u5165CAR-T\u7ec6\u80de\u6cbb\u7597\u9886\u57df\uff0c\u901a\u8fc7\u5f00\u521b\u6027\u6280\u672f\u6269\u5c55\u80bf\u7624\u7814\u53d1\u4ea7\u54c1\u7ebf \u8fd9\u662f\u5bf9Atara\u6280\u672f\u5e73\u53f0\u5728\u540c\u79cd\u5f02\u4f53\u7ec6\u80de\u6cbb\u7597\u9886\u57df\u9886\u5148\u5730\u4f4d\u7684\u8ba4\u53ef \u5408\u4f5c\u5c06\u5173\u6ce8\u4e0b\u4e00\u4ee3\u53ef\u666e\u53ca\u7684T\u7ec6\u80de\u514d\u75ab\u7597\u6cd5ATA3271\uff0c\u7528\u4e8e\u6cbb\u7597\u5b58\u5728\u95f4\u76ae\u7d20\u9ad8\u8868\u8fbe\u7684\u80bf\u7624 Atara\u516c\u53f8\u5c06\u6536\u52306,000\u4e07\u7f8e\u5143\u7684\u9884\u4ed8\u6b3e\uff0c\u548c\u57fa\u4e8e\u5f00\u53d1\u3001\u6ce8\u518c\u4e0e\u5546\u4e1a\u5316\u8fdb\u5c55\u7684\u6700\u9ad8\u53ef\u8fbe6.1\u4ebf\u7f8e\u5143\u7684\u91cc\u7a0b\u7891\u4ed8\u6b3e\uff0c\u4ee5\u53ca\u6700\u9ad8\u53ef\u8fbe\u51c0\u9500\u552e\u989d\u4f4e\u4e24\u4f4d\u6570\u767e\u5206\u6bd4\u7684\u5206\u5c42\u63d0\u6210 \u67cf\u6797\u548c\u52a0\u5229\u798f\u5c3c\u4e9a\u5dde\u5357\u65e7\u91d1\u5c712020\u5e7412\u67089\u65e5 \/\u7f8e\u901a\u793e\/ &#8212; \u62dc\u8033\u4e0eAtara\u751f\u7269\u533b\u836f\u516c\u53f8\u4e8e2020\u5e7412\u67087\u65e5\u5ba3\u5e03\u53cc\u65b9\u8fbe\u6210\u4e00\u9879\u72ec\u5bb6\u5168\u7403\u8bb8\u53ef\u534f\u8bae\uff0c\u5171\u540c\u5f00\u53d1\u7528\u4e8e\u6cbb\u7597\u5b9e\u4f53\u7624\u7684\u4e0b\u4e00\u4ee3\u95f4\u76ae\u7d20\u5bfc\u5411CAR-T\u7ec6\u80de\u7597\u6cd5\u3002\u8be5\u534f\u8bae\u5305\u62ec\u5f00\u53d1\u5019\u9009\u836f\u7269ATA3271\uff08\u4e00\u79cd\u589e\u5f3a\u578b\u4e0b\u4e00\u4ee3\u540c\u79cd\u5f02\u4f53T\u7ec6\u80de\u514d\u75ab\u7597\u6cd5\uff09\u4ee5\u53ca\u81ea\u4f53\u7248\u672c\u7684ATA2271\uff0c\u7528\u4e8e\u6cbb\u7597\u5b58\u5728\u95f4\u76ae\u7d20\u9ad8\u8868\u8fbe\u7684\u80bf\u7624\uff0c\u4f8b\u5982\u6076\u6027\u80f8\u819c\u95f4\u76ae\u7624\u4ee5\u53ca\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u3002 Atara\u516c\u53f8\u662f\u540c\u79cd\u5f02\u4f53T\u7ec6\u80de\u514d\u75ab\u7597\u6cd5\u9886\u57df\u7684\u5148\u884c\u8005\uff0c\u62e5\u6709\u884c\u4e1a\u9886\u5148\u7684\u540c\u79cd\u5f02\u4f53\u7ec6\u80de\u5236\u9020\u5de5\u827a\u548c\u4e0b\u4e00\u4ee3CAR-T\u6280\u672f\u3002\u6b64\u6b21\u8bb8\u53ef\u7684\u6280\u672f\u5229\u7528\u4e86Atara\u65b0\u578b\u7684\u4e13\u6709\u7231\u6cfc\u65af\u5766-\u5df4\u5c14\u75c5\u6bd2\uff08EBV\uff09T\u7ec6\u80de\u5e73\u53f0\uff0c\u5e76\u7ed3\u5408\u9488\u5bf9\u95f4\u76ae\u7d20\u7684\u4e0b\u4e00\u4ee3CAR-T\u6280\u672f\uff0c\u4ece\u800c\u63d0\u9ad8\u7597\u6548\uff0c\u6301\u4e45\u6027\uff0c\u5b89\u5168\u6027\u548c\u54cd\u5e94\u8010\u4e45\u6027\u3002 \u62dc\u8033\u7ec6\u80de\u4e0e\u57fa\u56e0\u6cbb\u7597\u5e73\u53f0\u8d1f\u8d23\u4ebaWolfram Carius\u8868\u793a\uff1a\u201c\u8fd9\u9879\u4ea4\u6613\u662f\u62dc\u8033\u5168\u65b0\u7ec6\u80de\u4e0e\u57fa\u56e0\u6cbb\u7597\u6218\u7565\u7684\u5173\u952e\u7ec4\u6210\u8981\u7d20\u3002\u516c\u53f8\u7684\u5f00\u53d1\u4ea7\u54c1\u7ec4\u5408\u901a\u8fc7\u540c\u79cd\u5f02\u4f53\u7ec6\u80de\u7597\u6cd5\u5f97\u5230\u4e86\u52a0\u5f3a\uff0c\u8fd9\u4e5f\u5de9\u56fa\u4e86\u6211\u4eec\u5728\u8be5\u9886\u57df\u5df2\u521d\u6b65\u5efa\u7acb\u7684\u9886\u5bfc\u5730\u4f4d\u3002\u6211\u4eec\u671f\u5f85\u4e0eAtara\u5408\u4f5c\uff0c\u4e3a\u8eab\u60a3\u96be\u4ee5\u6cbb\u7597\u7c7b\u578b\u764c\u75c7\u7684\u60a3\u8005\u5f00\u53d1\u4e0b\u4e00\u4ee3\u53ef\u666e\u53ca\u7684CAR-T\u7ec6\u80de\u7597\u6cd5\u3002\u201d Atara\u516c\u53f8\u603b\u88c1\u517c\u9996\u5e2d\u6267\u884c\u5b98Pascal Touchon\u8868\u793a\uff1a\u201c\u6b64\u6b21Atara\u4e0e\u62dc\u8033\u8fbe\u6210\u7684\u5408\u4f5c\u4ee4\u4eba\u5174\u594b\uff0c\u8fd9\u5c06\u52a0\u901f\u5f00\u53d1\u7528\u4e8e\u6cbb\u7597\u591a\u79cd\u7c7b\u578b\u5b9e\u4f53\u7624\u7684\u4e0b\u4e00\u4ee3\u95f4\u76ae\u7d20\u9776\u5411CAR-T\u7ec6\u80de\u7597\u6cd5\uff0c\u5e2e\u52a9\u6211\u4eec\u5229\u7528\u540c\u79cd\u5f02\u4f53\u7ec6\u80de\u6cbb\u7597\u5e73\u53f0\u7684\u80fd\u529b\u5c3d\u5feb\u9020\u798f\u60a3\u8005\u3002\u62dc\u8033\u5728\u80bf\u7624\u9886\u57df\u5168\u7403\u5f00\u53d1\u548c\u5546\u4e1a\u5316\u65b9\u9762\u53d6\u5f97\u7684\u4f18\u5f02\u6210\u7ee9\u4ee5\u53ca\u5728\u7ec6\u80de\u548c\u57fa\u56e0\u6cbb\u7597\u9886\u57df\u7684\u53d1\u5c55\u5b9e\u529b\uff0c\u5c06\u63d0\u5347Atara\u7684\u80fd\u529b\uff0c\u5e76\u6709\u529b\u8865\u5145\u6211\u4eec\u9886\u5148\u7684\u540c\u79cd\u5f02\u4f53T\u7ec6\u80de\u5e73\u53f0\u3002\u201d \u6839\u636e\u534f\u8bae\u6761\u6b3e\uff0cAtara \u5c06\u8d1f\u8d23ATA3271\u7684\u4e34\u5e8a\u7814\u7a76\u7533\u8bf7\uff08IND\uff09\u76f8\u5173\u7814\u7a76\u4ee5\u53ca\u5de5\u827a\u5f00\u53d1\uff0c\u62dc\u8033\u5c06\u8d1f\u8d23\u63d0\u4ea4IND\u4ee5\u53ca\u540e\u7eed\u4e34\u5e8a\u5f00\u53d1\u548c\u5546\u4e1a\u5316\u5de5\u4f5c\u3002\u6b64\u5916\uff0cAtara\u8fd8\u5c06\u7ee7\u7eed\u8d1f\u8d23ATA2711\u6b63\u5728\u8fdb\u884c\u4e2d\u7684I\u671f\u7814\u7a76\uff0c\u5176IND\u63d0\u4ea4\u5df2\u88ab\u63a5\u53d7\u4e14\u4e34\u5e8a\u7814\u7a76\u5df2\u542f\u52a8\u3002Atara\u5c06\u83b7\u5f976,000\u4e07\u7f8e\u5143\u7684\u9884\u4ed8\u6b3e\uff0c\u5e76\u4e14\u6709\u8d44\u683c\u6839\u636e\u5f00\u53d1\u3001\u6ce8\u518c\u53ca\u5546\u4e1a\u5316\u7684\u67d0\u4e9b\u7279\u5b9a\u91cc\u7a0b\u7891\u4e8b\u4ef6\u83b7\u5f97\u603b\u8ba1\u6700\u9ad8\u53ef\u8fbe6.1\u4ebf\u7f8e\u5143\u7684\u4ed8\u6b3e\uff0c\u4ee5\u53ca\u6700\u9ad8\u53ef\u8fbe\u51c0\u9500\u552e\u989d\u4f4e\u4e24\u4f4d\u6570\u767e\u5206\u6bd4\u7684\u5206\u5c42\u63d0\u6210\u3002 \u4f5c\u4e3a\u6b64\u4ea4\u6613\u7684\u4e00\u90e8\u5206\uff0cAtara\u8fd8\u5c06\u63d0\u4f9b\u8f6c\u5316\u53ca\u4e34\u5e8a\u751f\u4ea7\u670d\u52a1\uff0c\u62dc\u8033\u5c06\u652f\u4ed8\u76f8\u5173\u8d39\u7528\u3002\u6b64\u5916\uff0c\u62dc\u8033\u5728\u4e00\u5b9a\u671f\u9650\u5185\u8fd8\u4eab\u6709\u975e\u72ec\u5bb6\u6743\u5229\uff0c\u53ef\u5c31Atara\u5176\u4ed6CAR-T\u5019\u9009\u4ea7\u54c1\u7684\u8bb8\u53ef\u8fdb\u884c\u8c08\u5224\u3002 \u5173\u4e8eCAR-T\u7ec6\u80de\u7597\u6cd5 T\u7ec6\u80de\u662f\u767d\u7ec6\u80de\u7684\u4e00\u79cd\uff0c\u5bf9\u4e8e\u6e05\u9664\u5065\u5eb7\u4eba\u4f53\u5185\u7684\u5f02\u5e38\u7ec6\u80de\u548c\u764c\u7ec6\u80de\u81f3\u5173\u91cd\u8981\u3002\u5728\u764c\u75c7\u60a3\u8005\u4e2d\uff0c\u8fd9\u4e9bT\u7ec6\u80de\u7ecf\u5e38\u65e0\u6cd5\u8bc6\u522b\u6216\u6709\u6548\u5730\u4e0e\u764c\u7ec6\u80de\u76f8\u7ed3\u5408\u3002CAR-T\u7ec6\u80de\u7597\u6cd5\u901a\u8fc7\u5de5\u7a0b\u6539\u9020\u4eba\u7c7bT\u7ec6\u80de\u6765\u8868\u8fbe\u5d4c\u5408\u6297\u539f\u53d7\u4f53\uff08CAR\uff09\uff0c\u4ece\u800c\u63d0\u9ad8\u5176\u8bc6\u522b\u764c\u75c7\u7ec6\u80de\u7684\u80fd\u529b\u3002\u8fd9\u4e9b\u7597\u6cd5\u5229\u7528\u514d\u75ab\u7cfb\u7edf\u5bf9\u6297\u764c\u75c7\uff0c\u6709\u6f5c\u529b\u4e3a\u764c\u75c7\u6cbb\u7597\u5e26\u6765\u98a0\u8986\u6027\u7684\u6cbb\u7597\u624b\u6bb5\uff0c\u751a\u81f3\u662f\u6cbb\u6108\u7684\u53ef\u80fd\u3002\u95f4\u76ae\u7d20\u662f\u4e00\u79cd\u80bf\u7624\u7279\u5f02\u6027\u6297\u539f\uff0c\u901a\u5e38\u5728\u8bb8\u591a\u4fb5\u88ad\u6027\u5b9e\u4f53\u7624\u7ec6\u80de\u8868\u9762\u9ad8\u5ea6\u8868\u8fbe\uff0c\u662f\u5728\u5305\u62ecCAR-T\u7597\u6cd5\u5728\u5185\u7684\u514d\u75ab\u6cbb\u7597\u9886\u57df\u4e2d\u5907\u53d7\u5173\u6ce8\u7684\u4e00\u4e2a\u9776\u70b9\u3002 \u5173\u4e8e\u62dc\u8033\u65b0\u7684\u7ec6\u80de\u4e0e\u57fa\u56e0\u6cbb\u7597\uff08C&amp;GT\uff09\u5e73\u53f0 \u4e3a\u6269\u5c55\u5728\u7ec6\u80de\u4e0e\u57fa\u56e0\u6cbb\u7597\u9886\u57df\u7684\u5b9e\u529b\uff0c\u62dc\u8033\u6b63\u5728\u52a0\u5f3a\u516c\u53f8\u5185\u90e8\u76f8\u5173\u80fd\u529b\uff0c\u540c\u65f6\u4e5f\u5728\u5bfb\u6c42\u5916\u90e8\u6218\u7565\u5408\u4f5c\uff0c\u6280\u672f\u6536\u8d2d\u4ee5\u53ca\u8bb8\u53ef\u4ea4\u6613\uff0c\u5176\u76ee\u6807\u662f\u5efa\u7acb\u5f3a\u5927\u7684\u5e73\u53f0\uff0c\u62e5\u6709\u8de8\u4e0d\u540c\u6cbb\u7597\u9886\u57df\u7684\u5e7f\u6cdb\u5e94\u7528\u3002\u4ece\u6218\u7565\u5c42\u9762\u800c\u8a00\uff0c\u62dc\u8033\u5173\u6ce8\u7ec6\u80de\u4e0e\u57fa\u56e0\u6cbb\u7597\u7684\u7279\u5b9a\u9886\u57df\uff0c\u4f8b\u5982\uff0c\u5e94\u7528\u4e8e\u4e0d\u540c\u9002\u5e94\u75c7\u7684\u5e72\u7ec6\u80de\u7597\u6cd5\uff08\u805a\u7126\u5728\u8bf1\u5bfc\u6027\u591a\u529f\u80fd\u5e72\u7ec6\u80de\u6216\u79f0\u4e3aiPSCs\uff09\uff0c\u57fa\u56e0\u589e\u5f3a\uff0c\u57fa\u56e0\u7f16\u8f91\u4ee5\u53ca\u540c\u79cd\u5f02\u4f53\u7ec6\u80de\u7597\u6cd5\u3002\u5c06\u5916\u90e8\u521b\u65b0\u4e0e\u62dc\u8033\u56e2\u961f\u7684\u81ea\u8eab\u4e13\u957f\u76f8\u7ed3\u5408\u662f\u4e00\u9879\u5173\u952e\u7684\u4ef7\u503c\u9a71\u52a8\u529b\uff0c\u7279\u522b\u662f\u5728\u7ec6\u80de\u4e0e\u57fa\u56e0\u6cbb\u7597\u8fd9\u4e2a\u9ad8\u901f\u53d1\u5c55\u4e14\u7ade\u4e89\u6fc0\u70c8\u7684\u9886\u57df\u3002\u5728\u62dc\u8033\u7ec6\u80de\u4e0e\u57fa\u56e0\u6cbb\u7597\u5e73\u53f0\u7684\u8fd0\u8425\u6a21\u5f0f\u4e0b\uff0c\u5408\u4f5c\u4f19\u4f34\u5c06\u53ef\u4ee5\u81ea\u4e3b\u8fd0\u8425\uff0c\u5168\u9762\u8d1f\u8d23\u5f00\u53d1\u5e76\u63a8\u8fdb\u4ed6\u4eec\u7684\u4ea7\u54c1\u7ec4\u5408\u53ca\u6280\u672f\uff0c\u8fd9\u5bf9\u4e8e\u4fdd\u7559\u5176\u521b\u4e1a\u6587\u5316\u5e76\u5c06\u62dc\u8033\u4f5c\u4e3a\u9996\u9009\u5408\u4f5c\u4f19\u4f34\u7684\u5b9a\u4f4d\u800c\u8a00\u81f3\u5173\u91cd\u8981\u3002\u62dc\u8033\u7ec6\u80de\u4e0e\u57fa\u56e0\u6cbb\u7597\u5e73\u53f0\u7684\u89d2\u8272\u662f\u8fdb\u884c\u6218\u7565\u6307\u5bfc\uff0c\u786e\u4fdd\u4e0b\u5c5e\u5404\u7ec4\u6210\u90e8\u95e8\u80fd\u6709\u6548\u4e92\u8865\uff0c\u5c06\u6700\u597d\u7684\u751f\u7269\u79d1\u6280\u4e0e\u5236\u836f\u4e13\u957f\u6709\u673a\u7ed3\u5408\u3002\u4f5c\u4e3a\u62dc\u8033\u5904\u65b9\u836f\u4e8b\u4e1a\u90e8\u7684\u7ec4\u6210\u90e8\u5206\uff0c\u7ec6\u80de\u4e0e\u57fa\u56e0\u6cbb\u7597\u5e73\u53f0\u5c06\u7ed3\u5408\u591a\u9879\u91cd\u8981\u804c\u80fd\uff0c\u4e3a\u7ec6\u80de\u548c\u57fa\u56e0\u7597\u6cd5\u7814\u7a76\u4e0e\u5f00\u53d1\u5de5\u4f5c\u7684\u6574\u4e2a\u4ef7\u503c\u94fe\u63d0\u4f9b\u652f\u6301\uff0c\u5305\u62ec\u5728\u7814\u7a76\u4e0e\u4e34\u5e8a\u524d\u5f00\u53d1\uff0c\u5316\u5b66\u3001\u5236\u9020\u548c\u63a7\u5236\uff08CMC\uff09\uff0c\u4e34\u5e8a\u5f00\u53d1\uff0c\u5546\u4e1a\u5316\uff0c\u6218\u7565\u5b9e\u65bd\u4ee5\u53ca\u9879\u76ee\u7ba1\u7406\u7b49\u65b9\u9762\u7684\u76f8\u5173\u4e13\u4e1a\u77e5\u8bc6\u3002\u51ed\u501f\u9ad8\u5ea6\u7075\u6d3b\u6027\uff0c\u8be5\u5e73\u53f0\u5c06\u534f\u8c03\u4ece\u79d1\u5b66\u7814\u7a76\u5230\u4ea7\u54c1\u4e0a\u5e02\u7684\u5404\u9879\u8fd0\u8425\u5de5\u4f5c\uff0c\u81f4\u529b\u4e8e\u6253\u9020\u5e76\u4fdd\u6301\u53ef\u6301\u7eed\u7684\u7814\u53d1\u4ea7\u54c1\u7ebf\uff0c\u5c3d\u5feb\u5c06\u7a81\u7834\u6027\u79d1\u5b66\u6210\u679c\u63a8\u5411\u5e02\u573a\u3002 \u5173\u4e8e\u62dc\u8033 \u62dc\u8033\u4f5c\u4e3a\u4e00\u5bb6\u8de8\u56fd\u516c\u53f8\uff0c\u5728\u751f\u547d\u79d1\u5b66\u9886\u57df\u7684\u5065\u5eb7\u4e0e\u8425\u517b\u65b9\u9762\u5177\u6709\u6838\u5fc3\u7ade\u4e89\u529b\u3002\u516c\u53f8\u81f4\u529b\u4e8e\u901a\u8fc7\u4ea7\u54c1\u548c\u670d\u52a1\uff0c\u5e2e\u52a9\u4eba\u4eec\u514b\u670d\u5168\u7403\u4eba\u53e3\u4e0d\u65ad\u589e\u957f\u548c\u8001\u9f84\u5316\u5e26\u6765\u7684\u91cd\u5927\u6311\u6218\uff0c\u9020\u798f\u4eba\u7c7b\u3002\u540c\u65f6\uff0c\u96c6\u56e2\u8fd8\u901a\u8fc7\u79d1\u6280\u521b\u65b0\u548c\u4e1a\u52a1\u589e\u957f\u6765\u63d0\u5347\u76c8\u5229\u80fd\u529b\u5e76\u521b\u9020\u4ef7\u503c\u3002\u62dc\u8033\u81f4\u529b\u4e8e\u53ef\u6301\u7eed\u53d1\u5c55\u3002\u5728\u5168\u7403\uff0c\u62dc\u8033\u54c1\u724c\u4ee3\u8868\u7740\u53ef\u4fe1\u3001\u53ef\u9760\u53ca\u4f18\u8d28\u3002\u57282019\u8d22\u5e74\uff0c\u62dc\u8033\u7684\u5458\u5de5\u4eba\u6570\u7ea6\u4e3a104,000\u540d\uff0c\u9500\u552e\u989d\u4e3a435\u4ebf\u6b27\u5143\uff0c\u8d44\u672c\u652f\u51fa\u4e3a29\u4ebf\u6b27\u5143\uff0c\u7814\u7a76\u5f00\u53d1\u6295\u5165\u4e3a53\u4ebf\u6b27\u5143\u3002\u66f4\u591a\u4fe1\u606f\u8bf7\u89c1www.bayer.com\u3002 \u5173\u4e8eAtara Atara \u751f\u7269\u533b\u836f\u516c\u53f8\uff08Atara Biotherapeutics, Inc.\uff09\u4f5c\u4e3aT\u7ec6\u80de\u514d\u75ab\u7597\u6cd5\u9886\u57df\u7684\u5148\u884c\u8005\uff0c\u5229\u7528\u5176\u65b0\u578b\u7684\u540c\u79cd\u5f02\u4f53EBV T\u7ec6\u80de\u5e73\u53f0\u4e3a\u8eab\u60a3\u4e25\u91cd\u75be\u75c5\uff08\u5305\u62ec\u5b9e\u4f53\u7624\uff0c\u8840\u6db2\u80bf\u7624\u548c\u81ea\u8eab\u514d\u75ab\u6027\u75be\u75c5\uff09\u7684\u60a3\u8005\u5f00\u53d1\u53d8\u9769\u6027\u7684\u7597\u6cd5\u3002\u51ed\u501f\u6211\u4eec\u5728III\u671f\u4e34\u5e8a\u5f00\u53d1\u4e2d\u7684\u9886\u5148\u9879\u76ee\uff0cAtara\u662f\u9886\u5148\u7684\u540c\u79cd\u5f02\u4f53T\u7ec6\u80de\u514d\u75ab\u7597\u6cd5\u516c\u53f8\uff0c\u65e8\u5728\u4e3a\u5b58\u5728\u9ad8\u5ea6\u672a\u6ee1\u8db3\u533b\u7597\u9700\u6c42\u7684\u60a3\u8005\u5feb\u901f\u63d0\u4f9b\u53ef\u7528\u7684\u6cbb\u7597\u65b9\u6cd5\u3002\u6211\u4eec\u7684\u5e73\u53f0\u5229\u7528\u4e86EBV T\u7ec6\u80de\u7684\u72ec\u7279\u751f\u7269\u5b66\u7279\u6027\uff0c\u901a\u8fc7\u6574\u5408\u5de5\u7a0b\u5316\u7684CAR\uff08\u5d4c\u5408\u6297\u539f\u53d7\u4f53\uff09\u6216TCR\uff08T\u7ec6\u80de\u53d7\u4f53\uff09\uff0c\u62e5\u6709\u6cbb\u7597\u4f17\u591a\u4e0eEBV\u76f8\u5173\u7684\u75be\u75c5\u6216\u5176\u4ed6\u4e25\u91cd\u75be\u75c5\u7684\u80fd\u529b\u3002Atara\u6b63\u5229\u7528\u8fd9\u4e00\u5e73\u53f0\u521b\u9020\u5f3a\u5927\u7684\u7814\u53d1\u4ea7\u54c1\u7ebf\uff0c\u5176\u4e2d\u5305\u62ec\uff1a\u5904\u4e8eIII\u671f\u4e34\u5e8a\u5f00\u53d1\u9636\u6bb5\u7684tab-cel&reg;\uff08tabelecleucel\uff09\uff0c\u7528\u4e8e\u6cbb\u7597\u7231\u6cfc\u65af\u5766-\u5df4\u5c14\u75c5\u6bd2\u9a71\u52a8\u7684\u79fb\u690d\u540e\u6dcb\u5df4\u589e\u751f\u6027\u75be\u75c5\uff08EBV + PTLD\uff09\uff1bATA188\uff08\u4e00\u79cd\u9488\u5bf9EBV\u6297\u539f\u7684T\u7ec6\u80de\u514d\u75ab\u7597\u6cd5\uff09\uff0c\u53ef\u4f5c\u4e3a\u591a\u53d1\u6027\u786c\u5316\u75c7\u7684\u4e00\u79cd\u6f5c\u5728\u6cbb\u7597\u65b9\u6848\uff1b\u4ee5\u53ca\u591a\u79cd\u9488\u5bf9\u5b9e\u4f53\u7624\u548c\u8840\u6db2\u7cfb\u7edf\u6076\u6027\u80bf\u7624\u7684\u4e0b\u4e00\u4ee3\u5d4c\u5408\u6297\u539f\u53d7\u4f53T\u7ec6\u80de\uff08CAR-T\uff09\u514d\u75ab\u7597\u6cd5\u3002\u6539\u5584\u60a3\u8005\u7684\u751f\u6d3b\u662f\u6211\u4eec\u516c\u53f8\u7684\u4f7f\u547d\uff0c\u6211\u4eec\u5c06\u6301\u7eed\u4e0d\u65ad\u5730\u4e3a\u9700\u8981\u5e2e\u52a9\u7684\u4eba\u4eec\u5e26\u6765\u53d8\u9769\u6027\u5730\u7597\u6cd5\u3002&nbsp;Atara\u516c\u53f8\u7684\u603b\u90e8\u4f4d\u4e8e\u5357\u65e7\u91d1\u5c71\uff0c\u5e76\u5728\u52a0\u5229\u798f\u5c3c\u4e9a\u5dde\u5343\u6a61\u5e02\u8bbe\u7acb\u4e86\u9886\u5148\u7684\u7814\u53d1\u673a\u6784\u53ca\u751f\u4ea7\u5de5\u5382\u3002 \u524d\u77bb\u6027\u58f0\u660e \u672c\u65b0\u95fb\u7a3f\u5305\u62ec\u62dc\u8033\u96c6\u56e2\u7ba1\u7406\u5c42\u57fa\u4e8e\u5f53\u524d\u8bbe\u60f3\u548c\u9884\u6d4b\u6240\u4f5c\u7684\u524d\u77bb\u6027\u58f0\u660e\u3002\u5404\u79cd\u5df2\u77e5\u548c\u672a\u77e5\u7684\u98ce\u9669\u3001\u4e0d\u786e\u5b9a\u6027\u548c\u5176\u5b83\u56e0\u7d20\u5747\u53ef\u80fd\u5bfc\u81f4\u516c\u53f8\u672a\u6765\u7684\u5b9e\u9645\u8fd0\u8425\u7ed3\u679c\u3001\u8d22\u52a1\u72b6\u51b5\u3001\u53d1\u5c55\u6216\u4e1a\u7ee9\u4e0e\u4e0a\u8ff0\u524d\u77bb\u6027\u8868\u8ff0\u4e2d\u6240\u4f5c\u51fa\u7684\u4f30\u8ba1\u4ea7\u751f\u91cd\u5927\u5dee\u5f02\u3002\u8fd9\u4e9b\u56e0\u7d20\u5305\u62ec\u5728\u62dc\u8033\u5b98\u65b9\u7f51\u7ad9http:\/\/www.bayer.com\/ \u4e0a\u516c\u5f00\u7684\u62dc\u8033\u5404\u9879\u62a5\u544a\u3002\u672c\u516c\u53f8\u6ca1\u6709\u8d23\u4efb\u66f4\u65b0\u8fd9\u4e9b\u524d\u77bb\u6027\u58f0\u660e\u6216\u4f7f\u5176\u7b26\u5408\u672a\u6765\u53d1\u751f\u7684\u4e8b\u4ef6\u6216\u53d1\u5c55\u3002 \u76f8\u5173\u94fe\u63a5 : http:\/\/www.bayer.com&hellip; <a class=\"read-more\" href=\"https:\/\/www.xinwengao.com\/cn\/pr\/2020120911570013454\">Read More<\/a><\/p>\n","protected":false},"author":556,"featured_media":8278,"comment_status":"close","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1965],"tags":[],"class_list":["post-13454","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-partnerships"],"amp_enabled":true,"_links":{"self":[{"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/posts\/13454","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/users\/556"}],"replies":[{"embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/comments?post=13454"}],"version-history":[{"count":1,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/posts\/13454\/revisions"}],"predecessor-version":[{"id":13455,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/posts\/13454\/revisions\/13455"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/media\/8278"}],"wp:attachment":[{"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/media?parent=13454"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/categories?post=13454"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/tags?post=13454"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}