{"id":13383,"date":"2020-12-08T16:34:00","date_gmt":"2020-12-08T09:34:00","guid":{"rendered":"https:\/\/www.xinwengao.com\/cn\/pr\/2020120816340013383"},"modified":"2020-12-09T09:18:29","modified_gmt":"2020-12-09T01:18:29","slug":"ash-2020-%e9%99%86%e9%81%93%e5%9f%b9%e5%8c%bb%e9%99%a216%e9%a1%b9%e7%a0%94%e7%a9%b6%e5%85%a8%e9%9d%a2%e4%ba%ae%e7%9b%b8%ef%bc%8c%e5%ad%a6%e6%9c%af%e6%88%90%e6%9e%9c%e5%a4%a7%e4%b8%b0%e6%94%b6","status":"publish","type":"post","link":"https:\/\/www.xinwengao.com\/cn\/pr\/2020120816340013383","title":{"rendered":"ASH 2020 \u9646\u9053\u57f9\u533b\u966216\u9879\u7814\u7a76\u5168\u9762\u4eae\u76f8\uff0c\u5b66\u672f\u6210\u679c\u5927\u4e30\u6536"},"content":{"rendered":"<p><p>\u5317\u4eac2020\u5e7412\u67088\u65e5 \/\u7f8e\u901a\u793e\/ &#8212; \u7f8e\u56fd\u8840\u6db2\u5b66\u4f1a\uff08ASH\uff09\u5e74\u4f1a\u662f\u5168\u7403\u9996\u5c48\u4e00\u6307\u7684\u8840\u6db2\u5b66\u9886\u57df\u7684\u79d1\u5b66\u4ea4\u6d41\u76db\u4f1a\uff0c\u62e5\u6709\u6765\u81ea\u8fd1100\u4e2a\u56fd\u5bb6\u768418000\u591a\u540d\u4f1a\u5458\uff0c\u6bcf\u5e74\u90fd\u4f1a\u516c\u5e03\u548c\u53d1\u8868\u4e16\u754c\u5404\u56fd\u7684\u6700\u65b0\u8840\u6db2\u5b66\u6570\u636e\uff0c\u6c47\u96c6\u8be5\u9886\u57df\u6700\u65b0\u3001\u6700\u524d\u6cbf\u7684\u7814\u7a76\u8fdb\u5c55\uff0c\u91cd\u70b9\u4ecb\u7ecd\u8840\u6db2\u5b66\u6700\u65b0\u52a8\u6001\u3001\u6700\u70ed\u95e8\u8bdd\u9898\u3002\u53d7\u75ab\u60c5\u5f71\u54cd\uff0c\u7b2c62\u5c4aASH\u5e74\u4f1a\u4e8e2020\u5e7412\u67085-8\u65e5\u5728\u7ebf\u4e0a\u4e3e\u884c\u3002<\/p>\n<p>\u968f\u7740\u533b\u5b66\u6280\u672f\u7684\u8fdb\u6b65\u4e0e\u9769\u65b0\uff0c\u4e2d\u56fd\u5728\u4e16\u754c\u533b\u7597\u9886\u57df\u4e2d\u4e5f\u53d1\u6325\u7740\u65e5\u76ca\u91cd\u8981\u7684\u4f5c\u7528\uff0c\u8d8a\u6765\u8d8a\u591a\u7684\u4e2d\u56fd\u4e13\u5bb6\u5728ASH\u5e74\u4f1a\u4e0a\u5c55\u73b0\u98ce\u91c7\u3002<span id=\"spanHghltd91f\">\u5728<\/span>\u672c\u5c4aASH\u6458\u8981\u4e0a\u7ebf\u540e\uff0c\u7b2c\u4e00\u65f6\u95f4\u68c0\u7d22\u51fa34\u7bc7\u4e2d\u56fd\u4e13\u5bb6\u7684\u53e3\u5934\u53d1\u8a00\uff0c\u5176\u4e2d\u5305\u62ec\u8840\u6db2\u80bf\u7624\u76f8\u5173\u7684\u57fa\u7840\u548c\u4e34\u5e8a\u7814\u7a7627\u7bc7\uff0c\u9646\u9053\u57f9\u533b\u9662\u5165\u9009\u4e865\u7bc7\u53e3\u5934\u62a5\u544a\uff0c\u4e3a\u5168\u56fd\u5355\u4e2d\u5fc3\u4e4b\u9996\uff0c\u540c\u65f6\u66f4\u670911\u7bc7\u5899\u62a5\u5c55\u793a\uff0c\u53d6\u5f97\u4e1a\u5185\u77a9\u76ee\u7684\u5b66\u672f\u6210\u5c31\u3002<\/p>\n<p>\u6b64\u6b21\u5165\u9009\u76845\u7bc7\u53e3\u5934\u62a5\u544a\uff0c\u5168\u9762\u5c55\u793a\u4e86B\u7ec6\u80de\u6025\u6027\u6dcb\u5df4\u7ec6\u80de\u767d\u8840\u75c5\uff08B-ALL\uff09\u3001\u96be\u6cbb\u590d\u53d1\u7684\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\u7684CAR-T\u6cbb\u7597\u4ee5\u53caCRS\uff08\u7ec6\u80de\u56e0\u5b50\u91ca\u653e\u7efc\u5408\u5f81\uff09\u7684\u76d1\u6d4b\u65b9\u6cd5\u7b49\u51fa\u8272\u7684\u4e34\u5e8a\u7814\u7a76\u6210\u679c\u3002\u76f8\u4fe1\u901a\u8fc7\u672c\u6b21\u5927\u4f1a\u7684\u4ea4\u6d41\u4e0e\u5206\u4eab\uff0c<span id=\"spanHghltb955\">\u5c06<\/span>\u5bf9\u8840\u6db2\u75c5\u4e34\u5e8a\u6cbb\u7597\u624b\u6bb5\u7684\u53d1\u5c55\u4ee5\u53ca\u6cbb\u7597\u6548\u679c\u7684\u6539\u5584\u53d1\u6325\u51fa\u79ef\u6781\u7684\u63a8\u52a8\u4f5c\u7528\u3002<\/p>\n<div class=\"PRN_ImbeddedAssetReference\" id=\"DivAssetPlaceHolder4082\">\n<p><a href=\"https:\/\/mma.prnasia.com\/media2\/1360835\/image1.html\" target=\"_blank\" rel=\"nofollow noopener noreferrer\"><img decoding=\"async\" src=\"https:\/\/www.xinwengao.com\/cn\/wp-content\/uploads\/image1-216.jpg\" title=\"\u9646\u4f69\u534e\u9662\u957f\u5728ASH 2020\u5927\u4f1a\u4e0a\u4f5c\u4e863\u7bc7\u53e3\u5934\u53d1\u8a00\uff08\u6458\u8981\u53f7\uff1a159\u3001182\u3001270\uff09\" alt=\"\u9646\u4f69\u534e\u9662\u957f\u5728ASH 2020\u5927\u4f1a\u4e0a\u4f5c\u4e863\u7bc7\u53e3\u5934\u53d1\u8a00\uff08\u6458\u8981\u53f7\uff1a159\u3001182\u3001270\uff09\" \/><\/a><br \/><span>\u9646\u4f69\u534e\u9662\u957f\u5728ASH 2020\u5927\u4f1a\u4e0a\u4f5c\u4e863\u7bc7\u53e3\u5934\u53d1\u8a00\uff08\u6458\u8981\u53f7\uff1a159\u3001182\u3001270\uff09<\/span><\/p>\n<\/p><\/div>\n<p><b>\u53e3\u5934\u62a5\u544a\uff08<\/b><b>ORAL<\/b><b>\uff09<\/b><b>&nbsp;1<\/b><b>\uff1a<\/b><b>24<\/b><b>\u5c0f\u65f6\u5373\u53ef\u5236\u5907\u7684<\/b><b>CD19 \/ CD22<\/b><b>\u53cc\u9776\u70b9<\/b><b>FasT CAR-T<\/b><b>\uff08<\/b><b>GC022F<\/b><b>\uff09\u6cbb\u7597<\/b><b>B-ALL<\/b><b>\u7684\u7814\u7a76<\/b><\/p>\n<p><b>\u901a\u8baf\u4f5c\u8005\uff1a\u9646\u4f69\u534e\uff0c\u7b2c\u4e00\u4f5c\u8005\uff1a\u6768\u541b\u82b3\uff0c\u9646\u9053\u57f9\u533b\u9662\uff1b\u6458\u8981\u53f7\uff1a<\/b><b>159<\/b>&nbsp; <\/p>\n<p>\u8fd1\u5e74\u6765\u968f\u7740CAR-T\u7ec6\u80de\u7597\u6cd5\u7684\u5e7f\u6cdb\u5e94\u7528\uff0c\u4e5f\u66b4\u9732\u51fa\u4e00\u4e9b\u95ee\u9898\uff0c\u8fd9\u5176\u4e2d\u5c31\u5305\u62ecCAR-T\u7ec6\u80de\u7684\u5236\u5907\u65f6\u95f4\u548c\u6297\u539f\u9003\u9038\u7684\u95ee\u9898\u3002\u672c\u6587\u4e3b\u8981\u62a5\u9053\u4e86\u57fa\u4e8e\u4e00\u79cd\u65b0\u578b\u5236\u5907\u5e73\u53f0\u751f\u4ea7\u7684\u6297CD19 \/ CD22\u53cc\u9776\u70b9CAR-T\uff08GC022F\uff09\u6cbb\u7597\u6025\u6027B\u6dcb\u5df4\u7ec6\u80de\u767d\u8840\u75c5\uff08B-ALL\uff09\u7684I\u671f\u4e34\u5e8a\u7814\u7a76\uff08NCT04129099\uff09\u6570\u636e\u3002\u8be5\u9879\u7814\u7a76\u7684\u4e34\u5e8a\u524d\u7814\u7a76\u4ee5\u53ca\u4e34\u5e8a\u7814\u7a76\u7528CAR-T\u5236\u5242-CD19\/CD22\u53cc\u9776\u70b9FasT CAR-T\u7531\u4e98\u559c\u751f\u7269\u79d1\u6280\uff08\u4e0a\u6d77\uff09\u6709\u9650\u516c\u53f8\u5236\u5907\u63d0\u4f9b\u3002<\/p>\n<p>\u7814\u7a76\u8868\u660e\uff0c<b>\u5e94\u7528<\/b><b>FasT CAR<sup>TM<\/sup><\/b><b>\u6280\u672f\u53ef\u4ee5\u5728<\/b><b>24<\/b><b>\u5c0f\u65f6\u5185\u6210\u529f\u5236\u5907\u6297<\/b><b>CD19 \/ CD22<\/b><b>\u53cc\u9776\u70b9<\/b><b>CAR-T<\/b><b>\u7ec6\u80de\uff0c\u4e14\u8868\u578b\u66f4\u5e74\u8f7b\u3001\u8017\u7aed\u66f4\u5c11<\/b>\u3002\u800c\u4e14\uff0c\u4e0e\u4f20\u7edf\u7684CD19\/CD22\u53cc\u9776\u70b9CAR-T\u7ec6\u80de\u76f8\u6bd4\uff0c<b>GC022F<\/b><b>\u7ec6\u80de\u5728\u5f02\u79cd\u79fb\u690d\u5c0f\u9f20\u6a21\u578b\u4e2d\u7597\u6548\u66f4\u4f73\u3002<\/b>\u53e6\u5916\uff0c\u2160\u671f\u4e34\u5e8a\u6570\u636e\u8868\u660e\uff0c<b>GC022F<\/b><b>\u5728\u6cbb\u7597<\/b><b>CD19 +\/ CD22 +<\/b><b>\u7684<\/b><b>B-ALL<\/b><b>\u65b9\u9762\u662f\u5b89\u5168\u6709\u6548\u7684<\/b>\u3002<\/p>\n<p><b>\u53e3\u5934\u62a5\u544a\uff08<\/b><b>ORAL<\/b><b>\uff09<\/b><b>&nbsp;2<\/b><b>\uff1a\u6297<\/b><b>BCMA CAR-T<\/b><b>\u7ec6\u80de<\/b><b>&nbsp;[C-CAR088]<\/b><b>\u5bf9\u590d\u53d1\u6216\u96be\u6cbb\u6027<\/b><b>MM<\/b><b>\u663e\u793a\u51fa\u826f\u597d\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027<\/b><\/p>\n<p><b>\u901a\u8baf\u4f5c\u8005\uff1a\u9646\u4f69\u534e\uff0c\u9646\u9053\u57f9\u533b\u9662\uff0c\u7b2c\u4e00\u4f5c\u8005\uff1a\u5b89\u521a\uff0c\u4e2d\u56fd\u533b\u5b66\u79d1\u5b66\u9662\u8840\u6db2\u5b66\u7814\u7a76\u6240\u8840\u6db2\u75c5\u533b\u9662\uff1b\u6458\u8981\u53f7\uff1a<\/b><b>182<\/b><\/p>\n<p>C-CAR088\u7814\u7a76\u5728\u56db\u5bb6\u533b\u9662\u5f00\u5c55\uff0c\u5305\u62ec\u9646\u9053\u57f9\u533b\u9662\uff0c\u6c5f\u82cf\u7701\u4eba\u6c11\u533b\u9662\uff0c\u4e2d\u56fd\u533b\u5b66\u79d1\u5b66\u9662\u8840\u6db2\u75c5\u533b\u9662\uff0c\u5317\u4eac\u534f\u548c\u533b\u9662\uff0c\u6b64\u9879\u4e34\u5e8a\u524d\u548c\u4e34\u5e8a\u7814\u7a76\u6240\u7528\u7684C-CAR088\u4ea7\u54c1\u6765\u81ea\u4e8e\u897f\u6bd4\u66fc\u751f\u7269\u79d1\u6280\uff08\u4e0a\u6d77\uff09\u6709\u9650\u516c\u53f8\u3002<\/p>\n<p>C-<b>CAR088<\/b><b>\u662f\u4e00\u79cd\u9776\u5411<\/b><b>BCMA<\/b><b>\u7684\u65b0\u578b\u4e8c\u4ee3\u4ee5<\/b><b>4-1BB<\/b><b>\u4e3a\u5171\u523a\u6fc0\u5206\u5b50\u7684<\/b><b>&nbsp;CAR-T<\/b><b>\u7ec6\u80de\uff0c<\/b><b>BCMA<\/b><b>\u5728\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\uff08<\/b><b>MM<\/b><b>\uff09\u7ec6\u80de\u4e0a\u7279\u5f02\u6027\u9ad8\u8868\u8fbe<\/b>\u3002C-CAR088\u91c7\u7528\u65e0\u8840\u6e05\u3001\u81ea\u52a8\u5316\u548c\u6570\u5b57\u5c01\u95ed\u7cfb\u7edf\u5236\u9020\u3002\u5173\u4e8eR\/R MM\u60a3\u8005\u7684\u521d\u6b65\u4e34\u5e8a\u8bd5\u9a8c\u7ed3\u679c\u652f\u6301\u4e86\u6211\u4eec\u4e34\u5e8a\u524d\u7684\u7814\u7a76\u7ed3\u679c\uff0c\u5e76\u663e\u793a\u51fa\u4ee4\u4eba\u6b23\u559c\u7684\u7597\u6548\u548c\u53ef\u63a7\u7684\u5b89\u5168\u6027\u3002<\/p>\n<p><b>\u7814\u7a76\u663e\u793a\uff0c<\/b><b>C-CAR088<\/b><b>\u6cbb\u7597<\/b><b>R \/ R MM<\/b><b>\u60a3\u8005\u7684\u4e34\u5e8a\u8bd5\u9a8c\u7ed3\u679c\u663e\u793a\u826f\u597d\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027<\/b>\u3002\u5c06\u7ee7\u7eed\u8bc4\u4f30\u8fd9\u4e9b\u60a3\u8005\uff0c\u4ee5\u63a2\u7d22C-CAR088\u5bf9\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\u60a3\u8005\u7684\u957f\u671f\u7597\u6548\u3002<\/p>\n<p><b>\u53e3\u5934\u62a5\u544a\uff08<\/b><b>ORAL<\/b><b>\uff09<\/b><b>&nbsp;3<\/b><b>\uff1a\u65b0\u578b<\/b><b>CD19<\/b><b>\u9776\u5411\u5408\u6210<\/b><b>T<\/b><b>\u7ec6\u80de\u53d7\u4f53\u548c\u6297\u539f\u53d7\u4f53\uff08<\/b><b>STAR<\/b><b>\uff09<\/b><b>-T<\/b><b>\u7ec6\u80de\u6cbb\u7597<\/b><b>R\/R B-ALL<\/b><b>\u7684\u53ef\u884c\u6027\u548c\u5b89\u5168\u6027\u7814\u7a76<\/b><\/p>\n<p><b>\u901a\u8baf\u4f5c\u8005\uff1a\u9646\u4f69\u534e\uff0c\u7b2c\u4e00\u4f5c\u8005\uff1a\u5f20\u5f26\uff0c\u9646\u9053\u57f9\u533b\u9662\uff1b\u6458\u8981\u53f7\uff1a<\/b><b>270 <\/b>&nbsp;&nbsp;<\/p>\n<p>CAR-T\u7ec6\u80de\u7597\u6cd5\u5728B\u7ec6\u80de\u6076\u6027\u80bf\u7624\u60a3\u8005\u4e2d\u5df2\u663e\u793a\u51fa\u9ad8\u5e94\u7b54\u7387\uff0c\u4f46\u7f13\u89e3\u6301\u7eed\u65f6\u95f4\u548c\u5b89\u5168\u6027\u4ecd\u5f85\u63d0\u9ad8\u3002\u7814\u7a76\u8005\u5f00\u53d1\u4e86\u4e00\u79cd\u65b0\u578b\u7684\u53cc\u94fe\u5d4c\u5408\u53d7\u4f53-STAR\uff0c\u75312\u4e2a\u86cb\u767d\u8d28\u6a21\u5757\u7ec4\u6210\u3002\u672c\u6587\u62a5\u544a\u4e86STAR-T\u7ec6\u80de\u7597\u6cd5\u7684\u4e34\u5e8a\u524d\u7814\u7a76\u548cCD19 STAR-T\u7ec6\u80de\u6cbb\u7597B-ALL\u7684I\u671f\u4e34\u5e8a\u7814\u7a76\u7ed3\u679c\u3002\u8be5\u9879\u7814\u7a76\u7684\u4e34\u5e8a\u524d\u7814\u7a76\u4ee5\u53ca\u4e34\u5e8a\u7814\u7a76\u7528STAR-T\u7ec6\u80de\u5747\u7531\u6e05\u534e\u5927\u5b66\uff08\u533b\u5b66\u9662\uff09\u548c\u534e\u590f\u82f1\u6cf0\u751f\u7269\u79d1\u6280\u516c\u53f8\u7814\u53d1\u548c\u5236\u5907\u3002I\u671f\u4e34\u5e8a\u7814\u7a76\u5728\u9646\u9053\u57f9\u533b\u9662\u8fdb\u884c\u3002<\/p>\n<p>\u6b64\u4e34\u5e8a\u524d\u7814\u7a76\u8bc1\u660e\u4e86STAR-T\u7ec6\u80de\u5728\u4e34\u5e8a\u524d\u7814\u7a76\u53ca\u52a8\u7269\u6a21\u578b\u4e2d\u5728T\u7ec6\u80de\u6d3b\u5316\u80fd\u529b\u3001\u7ec6\u80de\u56e0\u5b50\u4ea7\u751f\u80fd\u529b\u548c\u6297\u80bf\u7624\u7597\u6548\u65b9\u9762\u6bd4\u5e38\u89c4CAR-T\u7ec6\u80de\u4f18\u8d8a\u3002<b>\u9996\u6b21\u7528\u5728\u4eba\u8eab\u4e0a\u7684<\/b><b>I<\/b><b>\u671f\u4e34\u5e8a\u7814\u7a76\u8bc1\u660e\u4e86<\/b><b>STAR-T<\/b><b>\u5728\u6cbb\u7597<\/b><b>CD19 + R \/ R B-ALL<\/b><b>\u4e2d\u7684\u6280\u672f\u53ef\u884c\u6027\u3001\u4e34\u5e8a\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u3002<\/b>\u8f93\u6ce8\u7b2c14\u5929\u5373\u53ef\u8fbe\u5230\u8f83\u9ad8\u7684CR\u7387\uff0c\u4e14\u6bd2\u6027\u8f83\u4f4e\u3002\u4f46\u4ecd\u9700\u5bf9\u8fd9\u4e9b\u60a3\u8005\u8fdb\u884c\u957f\u671f\u89c2\u5bdf\uff0c\u5e76\u8fdb\u884c\u66f4\u5927\u8303\u56f4\u7684\u60a3\u8005\u7814\u7a76\u3002<\/p>\n<div class=\"PRN_ImbeddedAssetReference\" id=\"DivAssetPlaceHolder9017\">\n<p><a href=\"https:\/\/mma.prnasia.com\/media2\/1360834\/image2.html\" target=\"_blank\" rel=\"nofollow noopener noreferrer\"><img decoding=\"async\" src=\"https:\/\/www.xinwengao.com\/cn\/wp-content\/uploads\/image2-189.jpg\" title=\"\u5f20\u5f26\u4e3b\u4efb\u5728ASH 2020\u5927\u4f1a\u4e0a\u4f5c\u53e3\u5934\u53d1\u8a00\uff08\u6458\u8981\u53f7\uff1a161\uff09\" alt=\"\u5f20\u5f26\u4e3b\u4efb\u5728ASH 2020\u5927\u4f1a\u4e0a\u4f5c\u53e3\u5934\u53d1\u8a00\uff08\u6458\u8981\u53f7\uff1a161\uff09\" \/><\/a><br \/><span>\u5f20\u5f26\u4e3b\u4efb\u5728ASH 2020\u5927\u4f1a\u4e0a\u4f5c\u53e3\u5934\u53d1\u8a00\uff08\u6458\u8981\u53f7\uff1a161\uff09<\/span><\/p>\n<\/p><\/div>\n<p><b>\u53e3\u5934\u62a5\u544a\uff08<\/b><b>ORAL<\/b><b>\uff09<\/b><b>&nbsp;4<\/b><b>\uff1a\u4f9b\u8005\u6765\u6e90<\/b><b>CD19 &#8211; CAR-T<\/b><b>\u7ec6\u80de\u6cbb\u7597\u96be\u6cbb<\/b><b>\/<\/b><b>\u590d\u53d1\u6025\u6027<\/b><b>B<\/b><b>\u6dcb\u5df4\u7ec6\u80de\u767d\u8840\u75c5\u7684\u53ef\u884c\u6027\u4e0e\u6709\u6548\u6027\u5206\u6790<\/b><\/p>\n<p><b>\u901a\u8baf\u4f5c\u8005\uff1a\u9646\u4f69\u534e\uff0c\u7b2c\u4e00\u4f5c\u8005\uff1a\u5f20\u5f26\uff0c\u9646\u9053\u57f9\u533b\u9662\uff1b\u6458\u8981\u53f7\uff1a<\/b><b>161&nbsp; <\/b><\/p>\n<p>CAR-T\u7ec6\u80de\u6cbb\u7597\u96be\u6cbb\u590d\u53d1\u6025\u6027B\u6dcb\u5df4\u7ec6\u80de\u767d\u8840\u75c5\uff08R\/R&nbsp;B-ALL\uff09\u7597\u6548\u663e\u8457\uff0c\u4f46\u662f\u56e0\u4e3a\u5176\u9700\u8981\u4ece\u60a3\u8005\u4f53\u5185\u91c7\u96c6\u6709\u6548\u7684T\u6dcb\u5df4\u7ec6\u80de\u8fdb\u884c\u81ea\u4f53CAR-T\u7ec6\u80de\u7684\u5236\u5907\uff0c\u5bf9\u4e8e<b>\u63a5\u53d7\u8fc7\u9ad8\u5f3a\u5ea6\u6cbb\u7597\u548c\u9ad8\u767d\u8840\u75c5\u7ec6\u80de\u8d1f\u8377\u7684\u60a3\u8005\uff0c\u5f80\u5f80\u65e0\u6cd5\u5236\u5907\u6709\u6548<\/b><b>CAR<\/b><b>&#8211;<\/b><b>T<\/b><b>\u7ec6\u80de\u3002<\/b>\u53e6\u5916\uff0c<b>\u5bf9\u4e8e\u5f02\u57fa\u56e0\u9020\u8840\u5e72\u7ec6\u80de\u79fb\u690d\u540e\u590d\u53d1\u7684\u60a3\u8005\uff0c\u662f\u5426\u53ef\u4ee5\u91c7\u96c6\u5176\u539f\u4f9b\u8005\u7684\u6dcb\u5df4\u7ec6\u80de\u57f9\u517b<\/b><b>CAR<\/b><b>&#8211;<\/b><b>T<\/b><b>\u7ec6\u80de\uff0c\u76ee\u524d\u6ca1\u6709\u7ed3\u8bba\u3002<\/b>\u8be5\u7814\u7a76\u5206\u6790\u4e8637\u4f8b\u6765\u81ea\u4eb2\u7f18\u4f9b\u8005\u7684CAR-T\u7ec6\u80de\u6cbb\u7597R\/R B-ALL\u60a3\u8005\u7684\u53ef\u884c\u6027\u548c\u6709\u6548\u6027\u3002<\/p>\n<p><b>\u7814\u7a76\u63d0\u793a\uff0c\u91c7\u96c6\u4eb2\u7f18\u4f9b\u8005\u6dcb\u5df4\u7ec6\u80de\u5236\u5907\u7684<\/b><b>CD19 CAR-T<\/b><b>\u7ec6\u80de\u662f\u53ef\u884c\u7684\u3002<\/b>\u5bf9\u4e8e\u5f02\u57fa\u56e0\u9020\u8840\u5e72\u7ec6\u80de\u79fb\u690d\u540e\u590d\u53d1\u7684\u60a3\u8005\uff0c\u6e90\u81ea\u539f\u79fb\u690d\u4f9b\u8005\u7684CAR-T\u7ec6\u80de\u662f\u5b89\u5168\u6709\u6548\u7684\uff0cCR\u7387\u9ad8\u8fbe96.4%\u3002\u5982\u679c\u60a3\u8005\u5728CAR-T\u7ec6\u80de\u6cbb\u7597\u4e4b\u524d\u6ca1\u6709\u51fa\u73b0GVHD\uff0c\u5219CAR-T\u7ec6\u80de\u4e4b\u540eGVHD\u7684\u53d1\u751f\u7387\u8f83\u4f4e\u3002\u8bd5\u9a8c\u8868\u660e\uff0c\u5728\u6ca1\u6709\u79fb\u690d\u53f2\u7684\u60a3\u8005\u4e2d\uff0c<b>\u5bf9\u4e8e\u75c5\u60c5\u5df2\u7ecf\u8fbe\u5230\u5f88\u665a\u671f\uff0c\u65e0\u6cd5\u91c7\u96c6\u81ea\u4f53\u6dcb\u5df4\u7ec6\u80de\u7684\u60a3\u8005\uff0c\u53ef\u4ee5\u91c7\u96c6\u6765\u81ea<\/b><b>HLA<\/b><b>\u540c\u80de\u5168\u5408\u4f9b\u8005\u7684<\/b><b>CAR-T<\/b><b>\u7ec6\u80de\u6cbb\u7597<\/b><b>&nbsp;<\/b><b>\uff0c\u800c\u6765\u81ea\u5355\u500d\u4f53\u76f8\u5408\u4f9b\u8005\u7684<\/b><b>CAR-T<\/b><b>\u7ec6\u80de\u6cbb\u7597\u7684\u7597\u6548\u8f83\u5dee\u3002\u4e24\u79cd\u4f9b\u8005\u6765\u6e90\u7684<\/b><b>CAR-T<\/b><b>\u7ec6\u80de\u6cbb\u7597\u5747\u672a\u5f15\u53d1<\/b><b>GVHD<\/b><b>\u3002<\/b><\/p>\n<div class=\"PRN_ImbeddedAssetReference\" id=\"DivAssetPlaceHolder2918\">\n<p><a href=\"https:\/\/mma.prnasia.com\/media2\/1360836\/image3.html\" target=\"_blank\" rel=\"nofollow noopener noreferrer\"><img decoding=\"async\" src=\"https:\/\/www.xinwengao.com\/cn\/wp-content\/uploads\/image3-148.jpg\" title=\"\u738b\u4e1c\u51fa\u533b\u5e08\u5728ASH 2020\u5927\u4f1a\u4e0a\u4f5c\u53e3\u5934\u53d1\u8a009\uff08\u6458\u8981\u53f7\uff1a200\uff09\" alt=\"\u738b\u4e1c\u51fa\u533b\u5e08\u5728ASH 2020\u5927\u4f1a\u4e0a\u4f5c\u53e3\u5934\u53d1\u8a009\uff08\u6458\u8981\u53f7\uff1a200\uff09\" \/><\/a><br \/><span>\u738b\u4e1c\u51fa\u533b\u5e08\u5728ASH 2020\u5927\u4f1a\u4e0a\u4f5c\u53e3\u5934\u53d1\u8a009\uff08\u6458\u8981\u53f7\uff1a200\uff09<\/span><\/p>\n<\/p><\/div>\n<p><b>\u53e3\u5934\u62a5\u544a\uff08<\/b><b>ORAL<\/b><b>\uff09<\/b><b>&nbsp;5<\/b><b>\uff1a\u6d41\u5f0f\u7ec6\u80de\u672f<\/b><b>Aimplex<\/b><b>\u5fae\u73e0\u6cd5\u68c0\u6d4b<\/b><b>24<\/b><b>\u79cd\u7ec6\u80de\u56e0\u5b50\u53ef\u4ee5\u6709\u6548\u89c2\u5bdf<\/b><b>CAR-T<\/b><b>\u7ec6\u80de\u6cbb\u7597\u540e\u7ec6\u80de\u56e0\u5b50\u91ca\u653e\u7efc\u5408\u5f81<\/b><\/p>\n<p><b>\u901a\u8baf\u4f5c\u8005\uff1a\u738b\u5349\uff0c\u7b2c\u4e00\u4f5c\u8005\uff1a\u738b\u4e1c\u51fa\uff0c\u9646\u9053\u57f9\u533b\u9662\uff1b\u6458\u8981\u53f7\uff1a<\/b><b>200&nbsp;&nbsp; <\/b><\/p>\n<p>\u8fd1\u5e74\u6765\u5d4c\u5408\u6297\u539f\u53d7\u4f53-T\u7ec6\u80de\uff08CAR-T\uff09\u6280\u672f\u7684\u5e94\u7528\u7ed9\u8840\u6db2\u548c\u5176\u4ed6\u80bf\u7624\u6cbb\u7597\u5e26\u6765\u9769\u547d\u6027\u8fdb\u5c55\uff0c\u7ec6\u80de\u56e0\u5b50\u76d1\u6d4b\u5728CAR-T\u548c\u79fb\u690d\u76f8\u5173\u514d\u75ab\u76d1\u6d4b\u4e2d\u8d77\u5230\u91cd\u8981\u4f5c\u7528\uff0c\u4f20\u7edf\u7684ELISA\u65b9\u6cd5\u5b58\u5728\u5f88\u591a\u6280\u672f\u7f3a\u9677\u3002<\/p>\n<p>2020\u5e74\u9646\u9053\u57f9\u533b\u7597\u96c6\u56e2\u738b\u4e1c\u51fa\u3001\u738b\u5349\u7b49\u8bbe\u8ba1\u4e86\u4e00\u9879\u65b0\u768424\u79cd\u7ec6\u80de\u56e0\u5b50\u7ec4\u5408\u65b9\u6848\uff0c\u91c7\u7528\u9769\u547d\u6027\u7684\u6d41\u5f0f\u7ec6\u80de\u672f\u5fae\u73e0\u6cd5\u9ad8\u901a\u91cf\u68c0\u6d4b\u591a\u79cd\u7ec6\u80de\u56e0\u5b50\uff0c\u9002\u7528\u4e8e\u5916\u5468\u8840\u3001\u8111\u810a\u6db2\u7684\u7b49\u591a\u79cd\u6807\u672c\uff0c\u6709\u6548\u68c0\u6d4bCAR-T\u540e\u514d\u75ab\u72b6\u6001\u3001\u8bc4\u4ef7\u7ec6\u80de\u56e0\u5b50\u98ce\u66b4\u4e25\u91cd\u7a0b\u5ea6\uff0c\u5e76\u5728\u8bc4\u4ef7\u79fb\u690d\u540eGVHD\u7b49\u5e76\u53d1\u75c7\u3001\u611f\u67d3\u514d\u75ab\u7b49\u8bc4\u4ef7\u4e2d\u53d6\u5f97\u826f\u597d\u6548\u679c\u3002\u4e0e\u4f20\u7edf\u7684ELISA\u65b9\u6cd5\u76f8\u6bd4\uff0c\u5177\u6709\u7075\u6d3b\u3001\u5feb\u901f\u3001\u9ad8\u6027\u4ef7\u6bd4\u3001\u8282\u7ea6\u6807\u672c\u7b49\u4f18\u70b9\u3002\u540c\u65f6\uff0c<b>\u7ec6\u80de\u56e0\u5b50\u7684\u68c0\u6d4b\u7ed3\u679c\u53ef\u660e\u786e<\/b><b>CRS<\/b><b>\u53cd\u5e94\u662f\u4f55\u79cd\u7ec6\u80de\u6d3b\u5316\u6240\u81f4\uff0c\u6709\u52a9\u4e8e\u6307\u5bfc\u4e34\u5e8a\u4f5c\u51fa\u51c6\u786e\u5e94\u5bf9\uff0c\u8fdb\u4e00\u6b65\u63d0\u9ad8\u60a3\u8005\u751f\u5b58\u7387\u3002<\/b><\/p>\n<p>\u4e00\u5e74\u4e00\u5c4a\u7684ASH\u5927\u4f1a\uff0c\u5bf9\u5168\u7403\u8840\u6db2\u75c5\u9886\u57df\u6765\u8bf4\uff0c\u662f\u65b0\u6280\u672f\u3001\u65b0\u6210\u679c\u7684\u4e00\u6b21\u68c0\u9605\u3002\u8fd1\u5e74\u6765\uff0c\u4e2d\u56fd\u8840\u6db2\u75c5\u754c\u540c\u4ec1\u4e0d\u65ad\u5c55\u73b0\u51fa\u4e0d\u5bb9\u5c0f\u89d1\u7684\u201c\u4e2d\u56fd\u529b\u91cf\u201d\uff0c\u4f5c\u4e3a\u6770\u51fa\u4ee3\u8868\u7684\u201c\u9053\u57f9\u58f0\u97f3\u201d\u4e5f\u8fde\u5e74\u5b9e\u529b\u4eae\u76f8\u56fd\u9645\u5b66\u672f\u821e\u53f0\u4e0a\uff0c\u5438\u5f15\u7740\u5168\u4e16\u754c\u540c\u884c\u7684\u76ee\u5149\u3002<\/p>\n<p>\u7825\u783a\u6df1\u8015\uff0c\u7b03\u884c\u81f4\u8fdc 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