{"id":13100,"date":"2020-12-07T22:00:00","date_gmt":"2020-12-07T15:00:00","guid":{"rendered":"https:\/\/www.xinwengao.com\/cn\/pr\/2020120722000013100"},"modified":"2020-12-08T09:15:35","modified_gmt":"2020-12-08T01:15:35","slug":"%e7%99%be%e6%b5%8e%e7%a5%9e%e5%b7%9e%e5%9c%a8%e7%ac%ac62%e5%b1%8a%e7%be%8e%e5%9b%bd%e8%a1%80%e6%b6%b2%e5%ad%a6%e4%bc%9a%ef%bc%88ash%ef%bc%89%e5%b9%b4%e4%bc%9a%e4%b8%8a%e5%85%ac%e5%b8%83%e7%99%be-2","status":"publish","type":"post","link":"https:\/\/www.xinwengao.com\/cn\/pr\/2020120722000013100","title":{"rendered":"\u767e\u6d4e\u795e\u5dde\u5728\u7b2c62\u5c4a\u7f8e\u56fd\u8840\u6db2\u5b66\u4f1a\uff08ASH\uff09\u5e74\u4f1a\u4e0a\u516c\u5e03\u767e\u60a6\u6cfd\u00ae\uff08\u6cfd\u5e03\u66ff\u5c3c\uff09\u7528\u4e8e\u6cbb\u7597B\u7ec6\u80de\u6076\u6027\u80bf\u7624\u548c\u534e\u6c0f\u5de8\u7403\u86cb\u767d\u8840\u75c7\u7684\u4e34\u5e8a\u8bd5\u9a8c\u6570\u636e"},"content":{"rendered":"<p><p><span 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type=\"disc\">\n<li>32\u4f8b\u5148\u524d\u63a5\u53d7\u4f0a\u5e03\u66ff\u5c3c\u6cbb\u7597\u5e76\u5bf9\u5176\u4e0d\u8010\u53d7\u7684\u60a3\u8005\u5171\u7ecf\u5386\u4e8666\u8d77\u4e0d\u8010\u53d7\u4e8b\u4ef6\uff0c\u5176\u4e2d58\u8d77\uff0888.0%\uff09\u5728\u60a3\u8005\u63a5\u53d7\u6cfd\u5e03\u66ff\u5c3c\u6cbb\u7597\u540e\u6ca1\u6709\u590d\u53d1\uff1b\u5728\u590d\u53d1\u76848\u8d77\u4e0d\u8010\u53d7\u4e8b\u4ef6\u4e2d\uff0c7\u8d77\u4e25\u91cd\u6027\u964d\u4f4e\uff0c1\u8d77\u7ef4\u6301\u5148\u524d\u4e8b\u4ef6\u7684\u4e25\u91cd\u6027 <\/li>\n<li>2\u4f8b\u5148\u524d\u63a5\u53d7\u963f\u5361\u66ff\u5c3c\u5e76\u5bf9\u5176\u4e0d\u8010\u53d7\u7684\u60a3\u8005\u5171\u7ecf\u5386\u4e864\u8d77\u4e0d\u8010\u53d7\u4e8b\u4ef6\uff0c\u5176\u4e2d2\u8d77\uff08\u5747\u4e3a\u5173\u8282\u75db\uff09\u5728\u60a3\u8005\u63a5\u53d7\u6cfd\u5e03\u66ff\u5c3c\u6cbb\u7597\u540e\u6ca1\u6709\u590d\u53d1\uff1b\u5728\u590d\u53d1\u76842\u8d77\u4e0d\u8010\u53d7\u4e8b\u4ef6\u4e2d\uff0c1\u8d77\u4e25\u91cd\u6027\u964d\u4f4e\uff0c1\u8d77\u7ef4\u6301\u5148\u524d\u4e8b\u4ef6\u7684\u4e25\u91cd\u6027 <\/li>\n<li>\u5171\u670925\u8d773\u7ea7\u4e0d\u8010\u53d7\u4e8b\u4ef6\u5728\u60a3\u8005\u63a5\u53d7\u4f0a\u5e03\u66ff\u5c3c\u53ca\/\u6216\u963f\u5361\u66ff\u5c3c\u6cbb\u7597\u65f6\u53d1\u751f\uff0c\u5176\u4e2d23\u8d77\u5728\u60a3\u8005\u63a5\u53d7\u6cfd\u5e03\u66ff\u5c3c\u6cbb\u7597\u540e\u6ca1\u6709\u590d\u53d1 <\/li>\n<li>4\u7ea7\u4e0d\u8010\u53d7\u4e8b\u4ef6\u5171\u67094\u8d77\uff0c\u5305\u62ec\u4e2d\u6027\u7c92\u7ec6\u80de\u51cf\u5c11\u75c7\uff08n=2\uff09\u3001\u4e19\u6c28\u9178\u6c28\u57fa\u8f6c\u79fb\u9176\uff08ALT\uff09\u5347\u9ad8\uff08n=1\uff09\u3001\u5929\u51ac\u6c28\u9178\u8f6c\u6c28\u9176\uff08AST\uff09\u5347\u9ad8\uff08n=1\uff09\uff0c\u5728\u63a5\u53d7\u6cfd\u5e03\u66ff\u5c3c\u6cbb\u7597\u540e\u5747\u672a\u590d\u53d1 <\/li>\n<li>26\u4f8b\u60a3\u8005\u5728\u63a5\u53d7\u6cfd\u5e03\u66ff\u5c3c\u6cbb\u7597\u4e2d\u7ecf\u5386\u4e86\u81f3\u5c11\u4e00\u8d77\u4efb\u4e00\u7ea7\u522b\u7684AE\uff0c\u6700\u5e38\u89c1\uff08\u226510.0%\uff09\u7684\u4e3a\u808c\u75db\uff0821.9%\uff09\u3001\u632b\u4f24\uff0818.8%\uff09\u3001\u54b3\u55fd\uff0815.6%\uff09\u3001\u6655\u7729\uff0815.6%\uff09\u53ca\u4e4f\u529b\uff0812.5%\uff09 <\/li>\n<li>8\u4f8b\u60a3\u8005\u5728\u63a5\u53d7\u6cfd\u5e03\u66ff\u5c3c\u6cbb\u7597\u4e2d\u7ecf\u5386\u4e86\u51fa\u8840\u4e8b\u4ef6\uff0c\u5747\u4e3a\u8f7b\u5ea6\uff1b <\/li>\n<li>\u57286\u4f8b\u66fe\u7531\u4e8e\u5fc3\u623f\u98a4\u52a8\u5bf9\u4f0a\u5e03\u66ff\u5c3c\u4e0d\u8010\u53d7\u7684\u60a3\u8005\u4e2d\uff0c\u5fc3\u623f\u98a4\u52a8\u672a\u518d\u53d1\u751f\u3002\u5fc3\u623f\u98a4\u52a8\u6216\u6251\u52a8\u57281\u4f8b\uff083.1%\uff09\u60a3\u8005\u4e2d\u590d\u53d1\uff0c\u8be5\u60a3\u8005\u5148\u524d\u63a5\u53d7\u4f0a\u5e03\u66ff\u5c3c\u6cbb\u7597\u5e76\u5bf9\u5176\u4e0d\u8010\u53d7\uff0c\u8be5\u4e8b\u4ef6\u5728\u63a5\u53d7\u6cfd\u5e03\u66ff\u5c3c\u6cbb\u7597\u540e\u4e25\u91cd\u6027\u964d\u4f4e\u3001\u6301\u7eed\u65f6\u95f4\u51cf\u77ed &#8212; \u5bf9\u6bd4\u63a5\u53d7\u4f0a\u5e03\u66ff\u5c3c\u65f6\u76843\u7ea7\u548c14\u5929\uff0c\u63a5\u53d7\u6cfd\u5e03\u66ff\u5c3c\u65f6\u5219\u4e3a2\u7ea7\u548c3\u5929 <\/li>\n<li>3\u4f8b\u60a3\u8005\u7ecf\u5386\u4e86\u81f3\u5c11\u4e00\u8d773\u7ea7\u53ca\u4ee5\u4e0aAE\uff0c\u5305\u62ec\u4e2d\u6027\u7c92\u7ec6\u80de\u51cf\u5c11\u75c7\uff08n=2\uff09\u53ca\u6655\u53a5\uff08n=1\uff09 <\/li>\n<li>\u672a\u51fa\u73b0\u4e25\u91cdAE\u6216\u7531\u4e8eAE\u5bfc\u81f4\u7684\u6cbb\u7597\u4e2d\u65ad<\/li>\n<\/ul>\n<p>\u622a\u81f3\u6570\u636e\u622a\u70b9\uff0c\u572818\u4f8b\u53ef\u8bc4\u4f30\u7597\u6548\u7684\u60a3\u8005\u4e2d\uff0813\u4f8bCLL\u60a3\u8005\uff0c4\u4f8bSLL\u60a3\u8005\u53ca1\u4f8bMCL\u60a3\u8005\uff09\uff0c17\u4f8b\u5728\u63a5\u53d7\u6cfd\u5e03\u66ff\u5c3c\u6cbb\u7597\u540e\u7f13\u89e3\u7ef4\u6301\u5148\u524d\u6c34\u5e73\uff08n=8\uff09\u6216\u5f97\u5230\u63d0\u9ad8\uff08n=9\uff09\u3002\u8fbe\u5230\u7b2c\u4e00\u6b21\u7f13\u89e3\u7684\u4e2d\u4f4d\u65f6\u95f4\u4e3a12.6\u4e2a\u661f\u671f\uff0cORR\u4e3a50.0%\uff0c\u5176\u4e2d\u5305\u62ec6\u4f8b\uff0833.3%\uff09PR\u4ee5\u53ca3\u4f8b\uff0816.7%\uff09\u4f34\u6709\u6dcb\u5df4\u7ec6\u80de\u589e\u591a\u7684PR\u3002<\/p>\n<p><b>\u5728\u4e2d\u56fd\u5f00\u5c55\u7684\u6cfd\u5e03\u66ff\u5c3c\u7528\u4e8e\u6cbb\u7597<\/b><b>R\/R WM<\/b><b>\u60a3\u8005\u7684\u5173\u952e\u6027<\/b><b>2<\/b><b>\u671f\u4e34\u5e8a\u8bd5\u9a8c<\/b><\/p>\n<p><i>\u5c55\u793a\u7f16\u53f7\uff1a<\/i><i>2940<\/i><\/p>\n<p>\u8fd9\u9879\u5355\u81c2\u3001\u5f00\u653e\u6027\u3001\u591a\u4e2d\u5fc3\u7684\u5173\u952e\u60272\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff08NCT03332173\uff09\u6570\u636e\u8868\u660e\u5728\u4e2d\u56fd\u7684R\/R WM\u60a3\u8005\u63a5\u53d7\u6cfd\u5e03\u66ff\u5c3c\u6cbb\u7597\u540e\u5f88\u5feb\u53d6\u5f97\u4e86\u6df1\u5ea6\u4e14\u6301\u4e45\u7684\u7f13\u89e3\u3002\u5171\u670944\u4f8b\u60a3\u8005\u5165\u7ec4\u8be5\u8bd5\u9a8c\uff0c\u6839\u636eWM\u9884\u540e\u8bc4\u5206\u7cfb\u7edf\uff0c\u5176\u4e2d20\u4f8b\u4e3a\u9ad8\u5371\u60a3\u8005\uff0c13\u4f8b\u4e3a\u4e2d\u5371\u60a3\u8005\u3002\u5171\u670943\u4f8b\u60a3\u8005\u7eb3\u5165\u7597\u6548\u8bc4\u4f30\u3002<\/p>\n<p>\u4e2d\u56fd\u533b\u5b66\u79d1\u5b66\u9662\u8840\u6db2\u75c5\u533b\u9662\u6dcb\u5df4\u7624\u8bca\u7597\u4e2d\u5fc3\u4e3b\u4efb\uff0c\u540c\u65f6\u4e5f\u662fBGB-3111-210\u7814\u7a76\u7684\u4e3b\u8981\u7814\u7a76\u8005\u90b1\u5f55\u8d35\u6559\u6388\u8bc4\u8bba\u9053\uff1a\u201c\u4eca\u5929\u516c\u5e03\u7684BGB-3111-210\u8bd5\u9a8c\u7ed3\u679c\u4ee4\u4eba\u6b23\u6170 &#8212; \u4e3b\u8981\u7f13\u89e3\u7387\u5c06\u8fd170%\uff0c\u800c\u8fbe\u5230\u4e3b\u8981\u7f13\u89e3\u7684\u4e2d\u4f4d\u8d77\u6548\u65f6\u95f4\u4e5f\u5728\u4e09\u4e2a\u6708\u4e4b\u5185\uff0c\u8bc1\u660e\u6cfd\u5e03\u66ff\u5c3c\u80fd\u5728\u534e\u6c0f\u5de8\u7403\u86cb\u767d\u8840\u75c7\u60a3\u8005\u4e2d\u5feb\u901f\u5730\u4ea7\u751f\u6df1\u5ea6\u4e14\u6301\u4e45\u7684\u7f13\u89e3\uff0c\u5c3d\u7ba1\u8fd9\u4e9b\u60a3\u8005\u4e2d\u5927\u591a\u6570\u4eba\u6839\u636e\u9884\u540e\u8bc4\u5206\u7cfb\u7edf\u5c5e\u4e8e\u4e2d\u5371\u6216\u9ad8\u5371\u3002\u6cfd\u5e03\u66ff\u5c3c\u7684\u5b89\u5168\u6027\u6570\u636e\u4e5f\u4e0e\u5148\u524d\u5728\u534e\u6c0f\u5de8\u7403\u86cb\u767d\u8840\u75c7\u60a3\u8005\u4e2d\u6240\u89c2\u5bdf\u5230\u7684\u6570\u636e\u76f8\u7b26\u3002\u6211\u4eec\u5e0c\u671b\u8fd9\u6b3eBTK\u6291\u5236\u5242\u80fd\u5728\u4e0d\u8fdc\u7684\u5c06\u6765\u6210\u4e3a\u4e2d\u56fd\u534e\u6c0f\u5de8\u7403\u86cb\u767d\u8840\u75c7\u60a3\u8005\u7684\u4e00\u4e2a\u65b0\u7684\u6709\u6548\u6cbb\u7597\u9009\u62e9\u3002\u201d<\/p>\n<p>\u622a\u81f3\u6570\u636e\u622a\u70b9<span id=\"spanHghlt1ff0\">2019\u5e748\u670831\u65e5<\/span>\uff0c27\u4f8b\u60a3\u8005\u4ecd\u5728\u63a5\u53d7\u8bd5\u9a8c\u6cbb\u7597\u3002\u5728\u4e2d\u4f4d\u968f\u8bbf\u65f6\u95f4\u4e3a18.58\u4e2a\u6708\u65f6\uff0c\u7ed3\u679c\u5305\u62ec\uff1a<\/p>\n<ul type=\"disc\">\n<li>\u5b9a\u4e49\u4e3a\u90e8\u5206\u7f13\u89e3\u6216\u66f4\u4f73\u7684\u4e3b\u8981\u7f13\u89e3\u7387\uff08MRR\uff09\u4e3a69.8%\uff0895% CI: 53.9, 82.8\uff09\uff0c\u5176\u4e2d\u975e\u5e38\u597d\u7684\u90e8\u5206\u7f13\u89e3\uff08VGPR\uff09\u7387\u4e3a32.6%\uff0c\u90e8\u5206\u7f13\u89e3\uff08PR\uff09\u7387\u4e3a37.2%\uff1b\u5b9a\u4e49\u4e3a\u8f7b\u5fae\u7f13\u89e3\u6216\u66f4\u4f73\u7684ORR\u4e3a79.1%\uff0895% CI: 64.0, 90.0\uff09 <\/li>\n<li>\u8fbe\u5230VGPR\u548c\u603b\u7f13\u89e3\u7684\u4e2d\u4f4d\u65f6\u95f4\u5206\u522b\u4e3a2.87\u4e2a\u6708\u548c2.76\u4e2a\u6708 <\/li>\n<li>\u4e2d\u4f4dPFS\u548c\u4e3b\u8981\u6301\u7eed\u7f13\u89e3\u65f6\u95f4\uff08DOMR\uff09\u5c1a\u672a\u5230\u8fbe <\/li>\n<li>\u6700\u5e38\u89c1\uff08\u226520.0%\uff09\u7684\u4efb\u4e00\u7ea7\u522b\u6cbb\u7597\u671f\u95f4\u51fa\u73b0\u7684\u4e0d\u826f\u4e8b\u4ef6\uff08TEAE\uff09\u4e3a\u4e2d\u6027\u7c92\u7ec6\u80de\u8ba1\u6570\u51cf\u5c11\uff0856.8%\uff09\u3001\u8840\u5c0f\u677f\u8ba1\u6570\u51cf\u5c11\uff0829.5%\uff09\u3001\u767d\u7ec6\u80de\u8ba1\u6570\u51cf\u5c11\uff0827.3%\uff09\u3001\u4e0a\u547c\u5438\u9053\u611f\u67d3\uff0827.3%\uff09\u3001\u8179\u6cfb\uff0825.0%\uff09\u3001\u4f53\u91cd\u589e\u52a0\uff0820.5%\uff09\u53ca\u5173\u8282\u75db\uff0820.5%\uff09 <\/li>\n<li>72.7%\u7684\u60a3\u8005\u7ecf\u5386\u4e86\u81f3\u5c11\u4e00\u8d773\u7ea7\u53ca\u4ee5\u4e0a\u7684TEAE\uff0c\u5176\u4e2d\u6700\u5e38\u89c1\uff08\u226510.0%\uff09\u7684\u4e3a\u4e2d\u6027\u7c92\u7ec6\u80de\u8ba1\u6570\u51cf\u5c11\uff0831.8%\uff09\u3001\u8840\u5c0f\u677f\u8ba1\u6570\u51cf\u5c11\uff0820.5%\uff09\u3001\u80ba\u90e8\u611f\u67d3\uff0813.6%\uff09\u53ca\u767d\u7ec6\u80de\u8ba1\u6570\u51cf\u5c11\uff0811.4%\uff09 <\/li>\n<li>50.0%\u7684\u60a3\u8005\u7ecf\u5386\u4e86\u81f3\u5c11\u4e00\u8d77\u4e25\u91cdTEAE\uff0c11.4%\u7684\u60a3\u8005\u7531\u4e8eTEAE\u4e2d\u65ad\u8bd5\u9a8c\u6cbb\u7597 <\/li>\n<li>4.5%\u7684\u60a3\u8005\u7531\u4e8eTEAE\u6b7b\u4ea1\uff0c\u5176\u4e2d1\u8d77\u4e3a\u591a\u5668\u5b98\u529f\u80fd\u969c\u788d\u7efc\u5408\u5f81\u548c\u6025\u6027\u4e59\u809d\uff0c\u53e61\u8d77\u4e3a\u4e0d\u660e\u539f\u56e0\u6b7b\u4ea1\uff0c\u7814\u7a76\u8005\u8003\u8651\u662f\u7531\u4e8eWM\u8fdb\u5c55\u548c\u5408\u5e76\u7684\u547c\u5438\u8870\u7aed\u6240\u81f4<\/li>\n<\/ul>\n<p><b>\u5173\u4e8e\u767e\u60a6\u6cfd<\/b><b><sup>&reg;<\/sup><\/b><b>\uff08\u6cfd\u5e03\u66ff\u5c3c\uff09<\/b><\/p>\n<p>\u767e\u60a6\u6cfd&reg;\uff08\u6cfd\u5e03\u66ff\u5c3c\uff09\u662f\u4e00\u6b3e\u7531\u767e\u6d4e\u795e\u5dde\u79d1\u5b66\u5bb6\u81ea\u4e3b\u7814\u53d1\u7684\u5e03\u9c81\u987f\u6c0f\u916a\u6c28\u9178\u6fc0\u9176\uff08BTK\uff09\u5c0f\u5206\u5b50\u6291\u5236\u5242\uff0c\u76ee\u524d\u6b63\u5728\u5168\u7403\u8fdb\u884c\u5e7f\u6cdb\u7684\u5173\u952e\u6027\u4e34\u5e8a\u8bd5\u9a8c\u9879\u76ee\uff0c\u4f5c\u4e3a\u5355\u836f\u548c\u4e0e\u5176\u4ed6\u7597\u6cd5\u8fdb\u884c\u8054\u5408\u7528\u836f\u6cbb\u7597\u591a\u79cdB\u7ec6\u80de\u6076\u6027\u80bf\u7624\u3002 <\/p>\n<p>\u767e\u60a6\u6cfd&reg;\u4e8e2019\u5e7411\u670814\u65e5\u83b7\u5f97\u7f8e\u56fd\u98df\u54c1\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08FDA\uff09\u52a0\u901f\u6279\u51c6\u7528\u4e8e\u6cbb\u7597\u65e2\u5f80\u63a5\u53d7\u8fc7\u81f3\u5c11\u4e00\u9879\u7597\u6cd5\u7684\u5957\u7ec6\u80de\u6dcb\u5df4\u7624\uff08MCL\uff09\u60a3\u8005\u3002\u8be5\u9879\u52a0\u901f\u6279\u51c6\u662f\u57fa\u4e8e\u603b\u7f13\u89e3\u7387\uff08ORR\uff09\u3002\u9488\u5bf9\u8be5\u9002\u5e94\u75c7\u7684\u6301\u7eed\u6279\u51c6\u5c06\u53d6\u51b3\u4e8e\u9a8c\u8bc1\u6027\u8bd5\u9a8c\u4e2d\u4e34\u5e8a\u76ca\u5904\u7684\u9a8c\u8bc1\u548c\u63cf\u8ff0\u3002 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