{"id":13085,"date":"2020-12-08T07:00:00","date_gmt":"2020-12-08T00:00:00","guid":{"rendered":"https:\/\/www.xinwengao.com\/cn\/pr\/2020120807000013085"},"modified":"2020-12-08T09:15:00","modified_gmt":"2020-12-08T01:15:00","slug":"%e4%bf%a1%e8%be%be%e7%94%9f%e7%89%a9%e5%9c%a8ash2020%e4%b8%8a%e5%85%ac%e5%b8%83parsaclisib%e5%9c%a8%e5%a4%8d%e5%8f%91%e6%88%96%e9%9a%be%e6%b2%bb%e6%80%a7b%e7%bb%86%e8%83%9e%e9%9d%9e%e9%9c%8d%e5%a5%87","status":"publish","type":"post","link":"https:\/\/www.xinwengao.com\/cn\/pr\/2020120807000013085","title":{"rendered":"\u4fe1\u8fbe\u751f\u7269\u5728ASH2020\u4e0a\u516c\u5e03Parsaclisib\u5728\u590d\u53d1\u6216\u96be\u6cbb\u6027B\u7ec6\u80de\u975e\u970d\u5947\u91d1\u6dcb\u5df4\u7624\u60a3\u8005\u4e2d\u4ea7\u751f\u5feb\u901f\u6301\u4e45\u4e14\u8f83\u9ad8\u7684\u7f13\u89e3\u7387"},"content":{"rendered":"

\u7f8e\u56fd\u65e7\u91d1\u5c71\u548c\u4e2d\u56fd\u82cf\u5dde2020\u5e7412\u67088\u65e5 \/\u7f8e\u901a\u793e\/ — \u4fe1\u8fbe\u751f\u7269\u5236\u836f\uff08\u9999\u6e2f\u8054\u4ea4\u6240\u80a1\u7968\u4ee3\u7801\uff1a01801\uff09\uff0c\u4e00\u5bb6\u81f4\u529b\u4e8e\u7814\u53d1\u3001\u751f\u4ea7\u548c\u9500\u552e\u7528\u4e8e\u6cbb\u7597\u80bf\u7624\u3001\u4ee3\u8c22\u75be\u75c5\u3001\u81ea\u8eab\u514d\u75ab\u7b49\u91cd\u5927\u75be\u75c5\u7684\u521b\u65b0\u836f\u7269\u7684\u751f\u7269\u5236\u836f\u516c\u53f8\uff0c\u4eca\u5929\u5728\u7b2c62\u5c4a\u7f8e\u56fd\u8840\u6db2\u5b66\u4f1a\u5e74\u4f1a\u548c\u535a\u89c8\u4f1a\uff08ASH 2020\uff09\u516c\u5e03\u4e86\u4e24\u9879\u5173\u4e8eParsaclisib\u4f5c\u4e3a\u4e00\u79cd\u5f3a\u6548\u3001\u9ad8\u9009\u62e9\u6027\u3001\u65b0\u4e00\u4ee3\u78f7\u8102\u9170\u808c\u91873-\u6fc0\u9176\u03b4<\/span>\uff08PI3K\u03b4<\/span>\uff09\u53e3\u670d\u6291\u5236\u5242\uff0c\u7528\u4e8e\u6cbb\u7597\u590d\u53d1\u6216\u96be\u6cbb\u6027\u6ee4\u6ce1\u6027\u6dcb\u5df4\u7624\uff08CITADEL-203\uff09\u548c\u8fb9\u7f18\u533a\u6dcb\u5df4\u7624\uff08CITADEL-204\uff09\u7684II\u671f\u7814\u7a76\u6570\u636e\u3002\u672c\u6b21ASH\u5e74\u4f1a\u4e8e2020\u5e7412\u67085\u65e5\u81f38\u65e5\u5728\u7ebf\u4e0a\u53ec\u5f00\u3002Parsaclisib\u7531Incyte\u7814\u53d1\uff0c\u4fe1\u8fbe\u751f\u7269\u4e0eIncyte\u5728\u4e2d\u56fd\u8054\u5408\u5f00\u53d1\u3002<\/p>\n

\u6b64\u6b21\u516c\u5e03\u7684\u4e24\u9879\u7814\u7a76CITADEL-203\u548c-204\u7684\u4e3b\u8981\u7ec8\u70b9\u662f\u5ba2\u89c2\u7f13\u89e3\u7387\uff08ORR\uff09\uff1b\u6b21\u8981\u7ec8\u70b9\u5305\u62ec\u7f13\u89e3\u6301\u7eed\u65f6\u95f4\uff08DOR\uff09\u3001\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff08PFS\uff09\u3001\u603b\u751f\u5b58\u671f\uff08OS\uff09\u3001\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\u3002\u6240\u6709\u57fa\u4e8e\u653e\u5c04\u5b66\u7684\u7ec8\u70b9\u7ed3\u679c\u5747\u57fa\u4e8e\u72ec\u7acb\u5ba1\u67e5\u59d4\u5458\u4f1a\uff08IRC\uff09\u8bc4\u4f30\u3002<\/p>\n<\/p>\n

\u7b26\u5408\u6761\u4ef6\u7684\u60a3\u8005\u5728\u516b\u5468\u5185\u6bcf\u5929\u4e00\u6b21\u63a5\u53d720 mg\u7684Parsaclisib\uff0c\u968f\u540e\u63a5\u53d7\u6bcf\u5468\u4e24\u6b21\uff08\u6bcf\u5468\u7528\u836f\u5242\u91cf\u7ec4[WG]\uff0920 mg\u6216\u6bcf\u5929\u4e00\u6b212.5 mg\uff08\u6bcf\u65e5\u7528\u836f\u5242\u91cf\u7ec4[DG]\uff09\u7684\u6cbb\u7597\u65b9\u6848\u3002\u6700\u7ec8\uff0c\u9009\u62e9\u4e86\u6bcf\u65e5\u4e00\u6b21\u5242\u91cf\u4f5c\u4e3a\u9996\u9009\u65b9\u6848\uff0c\u5141\u8bb8\u6700\u521d\u5165\u7ec4WG\u7684\u60a3\u8005\u8f6c\u6362\u4e3aDG\u65b9\u6848\u3002\u4f1a\u8bae\u516c\u5e03\u4e86DG\u7ec4\u548c\u6240\u6709\u60a3\u8005\u7684\u6570\u636e\u3002<\/p>\n

CITADEL\u7814\u7a76\u7684\u5173\u952e\u7ed3\u679c\u5305\u62ec\uff1a<\/p>\n

\n\n\n\n\n\n\n\n\n\n\n
<\/td>\n\n

ORR\uff0895%CI\uff09\uff0c%<\/span><\/p>\n<\/td>\n

\n

mDOR\uff0895%CI\uff09\uff0c\u6708<\/span><\/p>\n<\/td>\n

\n

mPFS\uff0895%CI\uff09\uff0c\u6708<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

CITADEL-203\uff1aR\/R\u6ee4\u6ce1\u6027\u6dcb\u5df4\u7624<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

DG\uff08N=95\uff09<\/span><\/p>\n<\/td>\n

\n

75\uff0865-83\uff09<\/span><\/p>\n<\/td>\n

\n

14.7\uff0812.0-17.5\uff09<\/span><\/p>\n<\/td>\n

\n

15.8\uff0813.8-19.1\uff09<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

\u6240\u6709\uff08N=118\uff09<\/span><\/p>\n<\/td>\n

\n

73\uff0864-81\uff09<\/span><\/p>\n<\/td>\n

\n

15.9\uff0812.0-NE\uff09<\/span><\/p>\n<\/td>\n

\n

15.8\uff0813.2-19.3\uff09<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

CITADEL-204\uff1aR\/R\u8fb9\u7f18\u533a\u6dcb\u5df4\u7624<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

DG\uff08N=72\uff09<\/span><\/p>\n<\/td>\n

\n

56.9\uff0844.7-68.6\uff09<\/span><\/p>\n<\/td>\n

\n

NR\uff088.1-NE\uff09<\/span><\/p>\n<\/td>\n

\n

NR\uff0811.0-NE\uff09<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

\u6240\u6709\uff08N=100\uff09<\/span><\/p>\n<\/td>\n

\n

57.0\uff0846.7-66.9\uff09<\/span><\/p>\n<\/td>\n

\n

12.0\uff089.3-NE\uff09<\/span><\/p>\n<\/td>\n

\n

19.4\uff0813.7-NE\uff09<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

R\/R\uff1a\u590d\u53d1\u6216\u96be\u6cbb\u6027\uff1bORR\uff1a\u5ba2\u89c2\u7f13\u89e3\u7387\uff1bmDOR\uff1a\u4e2d\u4f4d\u7f13\u89e3\u6301\u7eed\u65f6\u95f4\uff08\u7f13\u89e3\u8005\u62a5\u544a\u7ed3\u679c\uff09\uff1bmPFS\uff1a\u4e2d\u4f4d\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff1bDG\uff1a\u6bcf\u65e5\u7ed9\u836f\u5242\u91cf\u7ec4\u3002<\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table><\/div>\n

\u5728\u6240\u6709\u7814\u7a76\u4e2d\uff0cParsaclisib\u666e\u904d\u8010\u53d7\u826f\u597d\uff0c\u5b89\u5168\u6027\u53ef\u63a7\u3002<\/p>\n

\u4fe1\u8fbe\u751f\u7269\u533b\u5b66\u79d1\u5b66\u4e0e\u6218\u7565\u80bf\u7624\u90e8\u526f\u603b\u88c1\u5468\u8f89\u535a\u58eb\u8868\u793a\uff0c\u201c\u6211\u4eec\u5f88\u9ad8\u5174\u770b\u5230\u5728ASH 2020\u4e2d\u5c55\u73b0\u4e86\u4ee4\u4eba\u9f13\u821e\u7684CITADEL\u4e24\u9879\u7814\u7a76\u7ed3\u679c\uff0c\u7a81\u663e\u4e86Parsaclisib\u6709\u6f5c\u529b\u6210\u4e3a\u590d\u53d1\u6216\u96be\u6cbb\u6027B\u7ec6\u80de\u975e\u970d\u5947\u91d1\u6dcb\u5df4\u7624\u60a3\u8005\u7684\u6cbb\u7597\u9009\u62e9\u3002\u4e00\u9879\u5173\u952e\u6027II\u671f\u6ce8\u518c\u8bd5\u9a8c\u6b63\u5728\u4e2d\u56fd\u8fdb\u884c\u4e2d\uff0c\u65e8\u5728\u8bc4\u4f30Parsaclisib\u5bf9\u4e8e\u590d\u53d1\u548c\u96be\u6cbb\u6027\u6ee4\u6ce1\u6027\u6dcb\u5df4\u7624\u6216\u8fb9\u7f18\u533a\u6dcb\u5df4\u7624\u60a3\u8005\u7684\u6709\u6548\u6027\u548c\u5b89\u5168\u6027\uff0c\u6211\u4eec\u5c06\u6839\u636e\u7814\u7a76\u7ed3\u679c\uff0c\u79ef\u6781\u4e0e\u76d1\u7ba1\u90e8\u95e8\u6c9f\u901a\uff0c\u65e9\u65e5\u4e3a\u4e2d\u56fd\u590d\u53d1\u6216\u96be\u6cbb\u6027B\u7ec6\u80de\u975e\u970d\u5947\u91d1\u6dcb\u5df4\u7624\u60a3\u8005\u5e26\u6765\u66f4\u591a\u6cbb\u7597\u9009\u62e9\u3002\u201d<\/p>\n

2018\u5e7412\u6708\uff0c\u4fe1\u8fbe\u751f\u7269\u4e0eIncyte\u5c31Parsaclisib\uff08PI3K\u03b4<\/span>\u6291\u5236\u5242\uff09\u7b49\u4e09\u4e2a\u5904\u4e8e\u4e34\u5e8a\u8bd5\u9a8c\u9636\u6bb5\u7684\u5019\u9009\u836f\u7269\u8fbe\u6210\u6218\u7565\u5408\u4f5c\u3002\u6839\u636e\u534f\u8bae\u6761\u6b3e\uff0c\u4fe1\u8fbe\u751f\u7269\u62e5\u6709Parsaclisib\u53ca\u5176\u4ed6\u4e24\u4e2a\u5019\u9009\u836f\u7269\u5728\u4e2d\u56fd\u5927\u9646\u3001\u4e2d\u56fd\u9999\u6e2f\u3001\u4e2d\u56fd\u6fb3\u95e8\u548c\u4e2d\u56fd\u53f0\u6e7e\u5730\u533a\u7684\u5f00\u53d1\u548c\u5546\u4e1a\u5316\u6743\u5229\u3002\u76ee\u524d\u4fe1\u8fbe\u751f\u7269\u6b63\u5728\u4e2d\u56fd\u8fdb\u884c\u4e00\u9879\u91cd\u8981\u7684II\u671f\u6ce8\u518c\u8bd5\u9a8c\uff0c\u65e8\u5728\u8bc4\u4f30Parsaclisib\u5bf9\u4e8e\u590d\u53d1\u548c\u96be\u6cbb\u6027\u6ee4\u6ce1\u6027\u6dcb\u5df4\u7624\u6216\u8fb9\u7f18\u533a\u6dcb\u5df4\u7624\u60a3\u8005\u7684\u6709\u6548\u6027\u548c\u5b89\u5168\u6027\u3002<\/p>\n

\u76f8\u5173\u62a5\u544a\u7ed3\u679c\u53ef\u5728<\/i>ASH\u7f51\u7ad9\u83b7\u53d6\uff1ahttps:\/\/www.hematology.org\/meetings\/annual-meeting<\/a>; \uff03338\uff08\u53e3\u5934\u62a5\u544a\uff0cCITADEL-204\uff09\uff0c\uff032935\uff08\u6d77\u62a5\uff0cCITADEL-203\uff09\u3002<\/i><\/p>\n

\u5173\u4e8e\u6ee4\u6ce1\u6027\u6dcb\u5df4\u7624<\/b>\/\u8fb9\u7f18\u533a\u6dcb\u5df4\u7624<\/b><\/p>\n

\u6ee4\u6ce1\u6027\u6dcb\u5df4\u7624\u662f\u4e00\u79cdB\u7ec6\u80de\u6dcb\u5df4\u7624\uff0c\u75c5\u56e0\u4e3a\u4e2d\u5fc3\u7ec6\u80de\u548c\u4e2d\u5fc3\u6bcd\u7ec6\u80de\u7684\u7279\u5b9a\u7c7b\u578bB\u7ec6\u80de\u4e0d\u53d7\u63a7\u5236\u7684\u5206\u88c2\u3002\u867d\u7136\u6ee4\u6ce1\u6027\u6dcb\u5df4\u7624\u88ab\u5f52\u7c7b\u4e3a\u60f0\u6027\u6dcb\u5df4\u7624\uff0c\u4e14\u76ee\u524d\u5316\u5b66\u514d\u75ab\u7597\u6cd5\u5df2\u53d6\u5f97\u826f\u597d\u7597\u6548\uff0c\u4f46\u4ecd\u7ecf\u5e38\u590d\u53d1\u5e76\u4f34\u6709\u4fb5\u88ad\u6027\u75be\u75c5\uff0c\u53ef\u80fd\u5bfc\u81f4\u60a3\u8005\u57281~2 \u5e74\u5185\u6b7b\u4ea1\u3002\u590d\u53d1\/\u96be\u6cbb\u6027\u6ee4\u6ce1\u6027\u6dcb\u5df4\u7624\u7684\u6cbb\u7597\u9009\u62e9\u65b9\u9762\u4ecd\u5b58\u5728\u672a\u88ab\u6ee1\u8db3\u7684\u533b\u7597\u9700\u6c42\u3002<\/p>\n

\u8fb9\u7f18\u533a\u6dcb\u5df4\u7624\u4e5f\u662f\u4e00\u79cd\u60f0\u6027 B \u7ec6\u80de\u6dcb\u5df4\u7624\u3002\u867d\u7136BTK\u6291\u5236\u5242\u5df2\u7ecf\u5728\u7f8e\u56fd\u6279\u51c6\u7528\u4e8e\u6cbb\u7597\u590d\u53d1\/\u96be\u6cbb\u6027\u8fb9\u7f18\u533a\u6dcb\u5df4\u7624\uff0c\u4f46\u4f7f\u7528BTK\u6291\u5236\u5242\u6cbb\u7597\u540e\u62a5\u544a\u7684\u65e0\u75c5\u751f\u5b58\u671f\u8f83\u77ed\uff0c\u56e0\u6b64\u9700\u8981\u5728BTK\u6291\u5236\u5242\u7684\u57fa\u7840\u4e0a\u7ee7\u7eed\u5f00\u53d1\u65b0\u7684\u6cbb\u7597\u65b9\u6848\u3002<\/p>\n

\u5173\u4e8e<\/b>Parsaclisib<\/b><\/p>\n

Parsaclisib\uff08IBI-376\uff09\u662f\u4e00\u79cd\u5f3a\u6548\u3001\u9ad8\u9009\u62e9\u6027\u3001\u65b0\u4e00\u4ee3\u78f7\u8102\u9170\u808c\u91873-\u6fc0\u9176\u03b4\uff08PI3K\u03b4\uff09\u53e3\u670d\u6291\u5236\u5242\u3002\u76ee\u524d\u6b63\u5728\u8bc4\u4f30Parsaclisib\u4f5c\u4e3a\u5355\u4e00\u7597\u6cd5\u5728\u6570\u9879II\u671f\u8bd5\u9a8c\u4e2d\u5bf9\u975e\u970d\u5947\u91d1\u6dcb\u5df4\u7624\uff08\u6ee4\u6ce1\u6027\u6dcb\u5df4\u7624\u3001\u8fb9\u7f18\u533a\u6dcb\u5df4\u7624\u548c\u5957\u7ec6\u80de\u6dcb\u5df4\u7624\uff09\u548c\u81ea\u8eab\u514d\u75ab\u6027\u6eb6\u8840\u6027\u8d2b\u8840\u7684\u6cbb\u7597\u6548\u679c\u3002\u6b64\u5916\uff0c Incyte\u4e5f\u6b63\u5728\u8fdb\u884cParsaclisib\u548cruxolitinib\u8054\u5408\u6cbb\u7597\u9aa8\u9ad3\u7ea4\u7ef4\u5316\u60a3\u8005\u7684\u6ce8\u518c\u4e34\u5e8a\u8bd5\u9a8c\u3002Incyte\u4e5f\u8ba1\u5212\u5f00\u5c55\u4e00\u9879\u8bd5\u9a8c\u4ee5\u8bc4\u4f30parsaclisib\u8054\u5408tafasitamab\u6cbb\u7597\u5f25\u6f2b\u6027B\u7ec6\u80de\u6dcb\u5df4\u7624\u3002<\/p>\n

2018\u5e7412\u6708\uff0c\u4fe1\u8fbe\u751f\u7269\u4e0eIncyte\u5c31Parsaclisib\uff08PI3K\u03b4<\/span>\u6291\u5236\u5242\uff09\u7b49\u4e09\u4e2a\u5904\u4e8e\u4e34\u5e8a\u8bd5\u9a8c\u9636\u6bb5\u7684\u5019\u9009\u836f\u7269\u8fbe\u6210\u6218\u7565\u5408\u4f5c\u3002\u6839\u636e\u534f\u8bae\u6761\u6b3e\uff0c\u4fe1\u8fbe\u751f\u7269\u62e5\u6709Parsaclisib\u53ca\u5176\u4ed6\u4e24\u4e2a\u5019\u9009\u836f\u7269\u5728\u4e2d\u56fd\u5927\u9646\u3001\u4e2d\u56fd\u9999\u6e2f\u3001\u4e2d\u56fd\u6fb3\u95e8\u548c\u4e2d\u56fd\u53f0\u6e7e\u5730\u533a\u7684\u5f00\u53d1\u548c\u5546\u4e1a\u5316\u6743\u5229\u3002<\/p>\n

\u5173\u4e8e\u4fe1\u8fbe\u751f\u7269<\/b><\/p>\n

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\u4fe1\u8fbe\u751f\u7269\u5df2\u7ec4\u5efa\u4e86\u4e00\u652f\u5177\u6709\u56fd\u9645\u5148\u8fdb\u6c34\u5e73\u7684\u9ad8\u7aef\u751f\u7269\u836f\u5f00\u53d1\u3001\u4ea7\u4e1a\u5316\u4eba\u624d\u56e2\u961f\uff0c\u5305\u62ec\u4f17\u591a\u6d77\u5f52\u4e13\u5bb6\uff0c\u5e76\u4e0e\u7f8e\u56fd\u793c\u6765\u5236\u836f\u3001Adimab\u3001Incyte\u3001MD Anderson \u764c\u75c7\u4e2d\u5fc3\u548c\u97e9\u56fdHanmi\u7b49\u56fd\u9645\u5408\u4f5c\u65b9\u8fbe\u6210\u6218\u7565\u5408\u4f5c\u3002\u4fe1\u8fbe\u751f\u7269\u5e0c\u671b\u548c\u5927\u5bb6\u4e00\u8d77\u52aa\u529b\uff0c\u63d0\u9ad8\u4e2d\u56fd\u751f\u7269\u5236\u836f\u4ea7\u4e1a\u7684\u53d1\u5c55\u6c34\u5e73\uff0c\u4ee5\u6ee1\u8db3\u767e\u59d3\u7528\u836f\u53ef\u53ca\u6027\u548c\u4eba\u6c11\u5bf9\u751f\u547d\u5065\u5eb7\u7f8e\u597d\u613f\u671b\u7684\u8ffd\u6c42\u3002\u8be6\u60c5\u8bf7\u8bbf\u95ee\u516c\u53f8\u7f51\u7ad9\uff1awww.innoventbio.com<\/a>\u3002<\/p>\n

\u76f8\u5173\u94fe\u63a5 :<\/p>\n

http:\/\/www.innoventbio.com<\/p>\n","protected":false},"excerpt":{"rendered":"

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