{"id":114865,"date":"2024-07-18T14:51:00","date_gmt":"2024-07-18T07:51:00","guid":{"rendered":"https:\/\/www.xinwengao.com\/cn\/pr\/20240718145100114865"},"modified":"2024-07-19T03:58:20","modified_gmt":"2024-07-18T19:58:20","slug":"%e5%8b%83%e6%9e%97%e6%a0%bc%e6%ae%b7%e6%a0%bc%e7%bf%b02024%e5%b9%b4%e4%b8%8a%e5%8d%8a%e5%b9%b4%e6%88%90%e7%bb%a9%e5%8d%95%e5%87%ba%e7%82%89%ef%bc%9a%e5%8a%a0%e9%80%9f%e6%8e%a8%e8%bf%9b%e4%ba%a7","status":"publish","type":"post","link":"https:\/\/www.xinwengao.com\/cn\/pr\/20240718145100114865","title":{"rendered":"\u52c3\u6797\u683c\u6bb7\u683c\u7ff02024\u5e74\u4e0a\u534a\u5e74\u6210\u7ee9\u5355\u51fa\u7089\uff1a\u52a0\u901f\u63a8\u8fdb\u4ea7\u54c1\u7ba1\u7ebf\uff0c\u8fbe\u6210\u91cd\u8981\u91cc\u7a0b\u7891"},"content":{"rendered":"<ul type=\"disc\">\n<li>\u516c\u53f8\u5728\u5fc3\u80be\u4ee3\u8c22\u5065\u5eb7\u4e0e\u80bf\u7624\u9886\u57df\u8fbe\u6210\u591a\u9879\u91cc\u7a0b\u7891<\/li>\n<li>\u5e74\u5185\u80bf\u7624\u3001\u7cbe\u795e\u5065\u5eb7\u4e0e\u80ba\u7ea4\u7ef4\u5316\u9886\u57df\u7684\u4e34\u5e8a\u7814\u7a76\u5c06\u53d1\u5e03\u6700\u65b0\u6570\u636e<\/li>\n<li>\u4e0a\u534a\u5e74\u51c0\u9500\u552e\u989d\u540c\u6bd4\u5b9e\u73b07.4%*\u7684\u5f3a\u52b2\u589e\u957f<\/li>\n<\/ul>\n<p><p><span class=\"legendSpanClass\">\u4e0a\u6d77<\/span><span class=\"legendSpanClass\">2024\u5e747\u670818\u65e5<\/span> \/\u7f8e\u901a\u793e\/ &#8212; 7\u670818\u65e5\uff0c\u4ee5\u7814\u53d1\u9a71\u52a8\u7684\u5168\u7403\u751f\u7269\u5236\u836f\u9886\u519b\u4f01\u4e1a\u52c3\u6797\u683c\u6bb7\u683c\u7ff0\u53d1\u5e03\u4e862024\u5e74\u4e0a\u534a\u5e74\u4e1a\u7ee9\u3002\u4eca\u5e74\u4e0a\u534a\u5e74\uff0c\u516c\u53f8\u5927\u5e45\u52a0\u901f\u63a8\u8fdb\u5173\u952e\u6cbb\u7597\u9886\u57df\u7684\u4ea7\u54c1\u7ba1\u7ebf\uff0c\u8fbe\u6210\u591a\u9879\u91cd\u8981\u91cc\u7a0b\u7891\u3002<\/p>\n<div class=\"PRN_ImbeddedAssetReference\" id=\"DivAssetPlaceHolder5586\">\n<p><a href=\"https:\/\/mma.prnasia.com\/media2\/2464238\/headquarters_ingelheim2.html\" target=\"_blank\" rel=\"nofollow noopener\"><img decoding=\"async\" src=\"https:\/\/www.xinwengao.com\/cn\/wp-content\/uploads\/headquarters_ingelheim2-2.jpg\" title=\"\" alt=\"\" \/><\/a><br \/><span><\/span><\/p>\n<\/p><\/div>\n<p>\u52c3\u6797\u683c\u6bb7\u683c\u7ff0\u5168\u7403\u6267\u884c\u8463\u4e8b\u4f1a\u4e3b\u5e2d\u51af\u4fdd\u548c\uff08Hubertus von Baumbach\uff09\u5148\u751f\u8868\u793a\uff1a&quot;\u6211\u4eec\u57284\u6708\u516c\u5e03\u7684\u516c\u53f8\u7814\u53d1\u89c4\u5212\u7684\u57fa\u7840\u4e0a\uff0c\u8fdb\u4e00\u6b65\u52a0\u5927\u7814\u53d1\u6295\u5165\u3002\u9488\u5bf9\u4ee3\u8c22\u529f\u80fd\u969c\u788d\u76f8\u5173\u7684\u8102\u80aa\u6027\u809d\u708e\uff0c\u6211\u4eec\u5df2\u516c\u5e03\u4e86\u632f\u594b\u4eba\u5fc3\u7684\u7814\u7a76\u6570\u636e\u3002\u63a5\u4e0b\u6765\uff0c\u6211\u4eec\u8fd8\u5c06\u53d1\u5e03\u80bf\u7624\u3001\u7cbe\u795e\u5065\u5eb7\u4e0e\u80ba\u7ea4\u7ef4\u5316\u9886\u57df\u7684\u6700\u65b0\u7814\u7a76\u7ed3\u679c\u3002\u8fd9\u4e9b\u65b0\u8fdb\u5c55\u7ed9\u4e88\u4e86\u6211\u4eec\u5145\u8db3\u4fe1\u5fc3\uff0c\u52a0\u901f\u63a8\u52a8\u8fd9\u4e9b\u665a\u671f\u5728\u7814\u836f\u7269\u4e0a\u5e02\u524d\u51c6\u5907\u3002\u6211\u4eec\u975e\u5e38\u9ad8\u5174\u770b\u5230\u516c\u53f8\u4ea7\u54c1\u7ba1\u7ebf\u98de\u901f\u53d1\u5c55\u3002&quot;<\/p>\n<p>\u52c3\u6797\u683c\u6bb7\u683c\u7ff0\u6301\u7eed\u63a8\u8fdb\u5904\u5728\u4e0d\u540c\u4e34\u5e8a\u8bd5\u9a8c\u9636\u6bb5\u7684\u7814\u53d1\u7ba1\u7ebf\u3002\u4e0a\u534a\u5e74\uff0c\u516c\u53f8\u5728\u5fc3\u8840\u7ba1\u4ee3\u8c22\u75be\u75c5\u3001\u7cbe\u795e\u5065\u5eb7\u4e0e\u80bf\u7624\u9886\u57df\u542f\u52a8\u4e865\u9879\u65b0\u7684I\u671f\u3001II\u671f\u6216III\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff1b\u5728\u708e\u75c7\u6027\u75be\u75c5\u9886\u57df\uff0c\u516c\u53f8\u7684\u5728\u7814\u4ea7\u54c1\u4e5f\u6210\u529f\u83b7\u5f972\u9879\u5feb\u901f\u901a\u9053\u8d44\u683c\u8ba4\u5b9a\u3002\u4e0e\u6b64\u540c\u65f6\uff0c\u516c\u53f8\u5ba3\u5e03\u8fbe\u62109\u9879\u7814\u53d1\u5408\u4f5c\u534f\u8bae\uff0c\u8986\u76d6\u5404\u6cbb\u7597\u9886\u57df\u4e0e\u6280\u672f\u5e73\u53f0\uff0c\u6781\u5927\u589e\u5f3a\u4e86\u516c\u53f8\u7684\u4eba\u7528\u836f\u54c1\u4ea7\u54c1\u7ec4\u5408\u3002<\/p>\n<p>\u52c3\u6797\u683c\u6bb7\u683c\u7ff0\u5168\u7403\u6267\u884c\u8463\u4e8b\u4f1a\u6210\u5458\u3001\u8d22\u52a1\u8d1f\u8d23\u4ebaFrank H&uuml;bler\u8868\u793a\uff1a&quot;\u968f\u7740\u6211\u4eec\u7814\u53d1\u7ba1\u7ebf\u5728\u6df1\u5ea6\u4e0e\u5e7f\u5ea6\u6301\u7eed\u62d3\u5c55\uff0c\u6211\u4eec\u5728\u8d44\u6e90\u914d\u7f6e\u65f6\u4fdd\u6301\u9ad8\u5ea6\u4e13\u6ce8\u3002\u6211\u4eec\u5e0c\u671b\u7aed\u5c3d\u6240\u80fd\u52a0\u901f\u4ea7\u54c1\u7814\u53d1\uff0c\u5c06\u6211\u4eec\u7684\u521b\u65b0\u836f\u54c1\u66f4\u5feb\u60e0\u53ca\u60a3\u8005\u3002&quot;<\/p>\n<p>\u5728\u6301\u7eed\u5f3a\u52b2\u7684\u5e02\u573a\u9700\u6c42\u62c9\u52a8\u4e0b\uff0c2024\u5e74\u4e0a\u534a\u5e74\u516c\u53f8\u51c0\u9500\u552e\u989d\u540c\u6bd4\u589e\u957f7.4%*\u81f3129\u4ebf\u6b27\u5143\uff0c\u5305\u62ec\u4eba\u7528\u836f\u54c1\u4e1a\u52a1\u7684\u6b27\u5510\u9759<sup>&reg;<\/sup>\u5bb6\u65cf\u4e0e\u7ef4\u52a0\u7279<sup>&reg;<\/sup>\uff0c\u4ee5\u53ca\u52a8\u7269\u4fdd\u5065\u4e1a\u52a1\u7684\u5c3c\u53ef\u4fe1<sup>&reg;<\/sup>\u5bb6\u65cf\u4ea7\u54c1\u7b49\u5728\u5185\u7684\u591a\u4e2a\u52c3\u6797\u683c\u4ea7\u54c1\u9a71\u52a8\u589e\u957f\u3002<\/p>\n<p><b>\u4eba\u7528\u836f\u54c1\u4e1a\u52a1<\/b><\/p>\n<p>\u52c3\u6797\u683c\u6bb7\u683c\u7ff0\u79ef\u6781\u4e3a\u672a\u6765\u4ea7\u54c1\u7ec4\u5408\u4ee5\u53ca\u5373\u5c06\u4e0a\u5e02\u7684\u4ea7\u54c1\u505a\u51c6\u5907\u3002\u8fc7\u53bb\u51e0\u4e2a\u6708\uff0c\u516c\u53f8\u5728\u6240\u6709\u91cd\u70b9\u6cbb\u7597\u9886\u57df\u90fd\u53d6\u5f97\u8fdb\u5c55\u3002\u5e74\u5185\uff0c\u516c\u53f8\u8fd8\u5c06\u53d1\u5e03\u80bf\u7624\uff08Zongertinib\uff09\u3001\u7cbe\u795e\u5065\u5eb7\uff08Iclepertin\uff09\u4e0e\u80ba\u7ea4\u7ef4\u5316\uff08Nerandomilast\uff09\u9886\u57df\u4e34\u5e8a\u7814\u7a76\u7684\u66f4\u591a\u6700\u65b0\u7ed3\u679c\u3002<\/p>\n<p>\u516c\u53f8\u5728\u4fc3\u8fdb\u6574\u4f53\u5fc3\u80be\u810f\u4ee3\u8c22 (CRM) \u5065\u5eb7\u65b9\u9762\u7684\u7814\u7a76\u52aa\u529b\u8fbe\u6210\u4e00\u7cfb\u5217\u91cd\u8981\u91cc\u7a0b\u7891\u3002\u5176\u4e2d\uff0csurvodutide\u6cbb\u7597\u4ee3\u8c22\u529f\u80fd\u969c\u788d\u76f8\u5173\u7684\u8102\u80aa\u6027\u809d\u708e\uff08MASH\uff09\u7684II\u671f\u4e34\u5e8a\u8bd5\u9a8c\u53d6\u5f97\u7a81\u7834\u6027\u7684\u79ef\u6781\u7ed3\u679c\uff1a\u4e0e\u5b89\u6170\u5242(18.2%)\u76f8\u6bd4\uff0c\u9ad8\u8fbe83%\u63a5\u53d7survodutide\u6cbb\u7597\u7684MASH\u6210\u4eba\u60a3\u8005\u5b9e\u73b0\u4e86\u5177\u6709\u7edf\u8ba1\u5b66\u610f\u4e49\u7684\u6539\u5584[\u7ec4\u95f4\u5dee\u5f02\uff1a64.8%\uff0c(CI 51.1% &#8211; 78.6%), p&lt;0.0001]\u3002\u6b64\u5916\uff0c\u8be5\u8bd5\u9a8c\u4e00\u9879\u4e9a\u7ec4\u5206\u6790\u7ed3\u679c\u663e\u793a\uff0c\u4e0e\u5b89\u6170\u5242(25.9%)\u76f8\u6bd4\uff0c\u591a\u8fbe64.5%\u7684F2\u548cF3\u671f\u7ea4\u7ef4\u5316\uff08\u4e2d\u5ea6\u81f3\u665a\u671f\u75a4\u75d5\uff09\u6210\u4eba\u60a3\u8005\u7684\u7ea4\u7ef4\u5316\u7a0b\u5ea6\u5f97\u5230\u6539\u5584\uff0c\u4e14MASH\u65e0\u6076\u5316 [\u7ec4\u95f4\u5dee\u5f02\uff1a38.6%\uff0c(95% CI 18.1% &#8211; 59.1%), p=0.0005]\u3002<sup>[1]<\/sup><\/p>\n<p>\u516c\u53f8\u542f\u52a8\u4e86\u4e00\u9879\u65b0\u578b\u9009\u62e9\u6027\u919b\u56fa\u916e\u5408\u9176\u6291\u5236\u5242\uff08ASi\uff09\u8054\u5408\u6069\u683c\u5217\u51c0\u6cbb\u7597\u6162\u6027\u5fc3\u529b\u8870\u7aed\u60a3\u8005\u7684III\u671f\u4e34\u5e8a\u8bd5\u9a8c\u3002\u52c3\u6797\u683c\u6bb7\u683c\u7ff0\u8fd8\u5c06\u4e0e\u725b\u6d25\u4eba\u53e3\u5065\u5eb7\u4e2d\u5fc3\u5408\u4f5c\uff0c\u5f00\u5c55\u4e00\u9879\u4f7f\u7528Asi\u6cbb\u7597\u6162\u6027\u80be\u75c5\u7684III\u671f\u4e34\u5e8a\u8bd5\u9a8c\u3002<\/p>\n<p>\u6b64\u5916\uff0c\u52c3\u6797\u683c\u6bb7\u683c\u7ff0\u5df2\u4e0e\u7f8e\u56fd\u5fc3\u810f\u534f\u4f1a\u5fc3\u80be\u4ee3\u8c22\u5065\u5eb7\u5021\u8bae\u8fbe\u6210\u591a\u5e74\u8d5e\u52a9\u534f\u8bae\u3002\u8fd9\u4e00\u6700\u65b0\u5ba3\u5e03\u7684\u4e3e\u63aa\u5c06\u5e2e\u52a9\u516c\u53f8\u66f4\u597d\u5730\u4e86\u89e3\u5fc3\u80be\u4ee3\u8c22\u5173\u8054\u6027\u75be\u75c5\u60a3\u8005\u7684\u8d1f\u62c5\uff0c\u4ece\u800c\u63d0\u4f9b\u66f4\u597d\u7684\u6cbb\u7597\u65b9\u6848\u3002<\/p>\n<p>\u52c3\u6797\u683c\u6bb7\u683c\u7ff0\u81f4\u529b\u4e8e\u901a\u8fc7\u5b9a\u5411\u6295\u8d44\u91cd\u8fd4\u80bf\u7624\u6cbb\u7597\u9886\u57df\u3002HER2\u7279\u5f02\u6027\u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5242Zongertinib\u6cbb\u7597HER2 \u53d8\u5f02\u9633\u6027\u5b9e\u4f53\u7624\u60a3\u8005\u7684Ia\/Ib\u671f\u8bd5\u9a8c\u7ed3\u679c\u8868\u660e\uff0cZongertinib\u5c55\u73b0\u51fa\u826f\u597d\u7684\u8010\u53d7\u6027\u4e0e\u663e\u8457\u7684\u6709\u6548\u6027<sup><span id=\"spanHghlt153c\">[2]<\/span><\/sup>\u3002\u6b64\u5916\uff0c\u5c3d\u7ba1Brigimadlin\u6cbb\u7597\u53bb\u5206\u5316\u8102\u80aa\u8089\u7624\u7684Brightline-1\u4e34\u5e8a\u8bd5\u9a8c\u672a\u8fbe\u5230\u4e3b\u8981\u7ec8\u70b9\uff0c\u4f46\u83b7\u76ca-\u98ce\u9669\u8bc4\u4f30\u7ed3\u679c\u4ecd\u4e3a\u9633\u6027\u3002\u5b8c\u6574\u7684\u8bd5\u9a8c\u7ed3\u679c\u5c06\u4e8e\u5e74\u5185\u665a\u4e9b\u7684\u533b\u5b66\u4f1a\u8bae\u4e0a\u516c\u5e03\u3002<span id=\"spanHghlt00de\">\u8fd9\u4e24\u9879\u4e34\u5e8a\u8bd5\u9a8c\u7ed3\u679c\u5c06\u4e8e\u8fd1\u51e0\u4e2a\u6708\u7684\u533b\u5b66\u4f1a\u8bae\u4e0a\u516c\u5e03\u3002<\/span><\/p>\n<p>2024\u5e74\u4e0a\u534a\u5e74\uff0c\u52c3\u6797\u683c\u6bb7\u683c\u7ff0\u4eba\u7528\u836f\u54c1\u4e1a\u52a1\u51c0\u9500\u552e\u989d\u540c\u6bd4\u589e\u957f9.3%*\u8fbe103\u4ebf\u6b27\u5143\uff0c\u4e3b\u8981\u5f97\u76ca\u4e8e\u6b27\u5510\u9759<sup>&reg;<\/sup>\u5bb6\u65cf\u548c\u7ef4\u52a0\u7279<sup>&reg;<\/sup>\u7684\u5f3a\u52b2\u8868\u73b0\u3002\u4e3a\u4e86\u6ee1\u8db3\u4e0d\u65ad\u589e\u957f\u7684\u5e02\u573a\u9700\u6c42\uff0c\u52c3\u6797\u683c\u6bb7\u683c\u7ff0\u5bf9\u751f\u4ea7\u4e0e\u4f9b\u5e94\u7f51\u7edc\u6301\u7eed\u9ad8\u4f4d\u6295\u8d44\u3002\u4eca\u5e741\u6708\uff0c\u52c3\u6797\u683c\u6bb7\u683c\u7ff0\u5ba3\u5e03\u6295\u8d441.2\u4ebf\u6b27\u5143\u5347\u7ea7\u6269\u5efa\u4f4d\u4e8e\u5e0c\u814aKoropi\u7684\u5de5\u5382\uff0c\u65e8\u5728\u63d0\u5347\u65b0\u4e0a\u5e02\u4e0e\u73b0\u6709\u836f\u54c1\u7684\u4ea7\u80fd\uff0c\u5305\u62ec\u5904\u4e8e\u665a\u671f\u5f00\u53d1\u9636\u6bb5\u7684\u4e00\u4e9b\u5728\u7814\u4ea7\u54c1\u3002<\/p>\n<p><b>\u52a8\u7269\u4fdd\u5065\u4e1a\u52a1<\/b><\/p>\n<p>\u5728\u755c\u79bd\u4e1a\u52a1\u9886\u57df\uff0c\u5bb6\u79bd\u75ab\u82d7VAXXITEK\u4ea7\u54c1\u7ec4\u5408\u6301\u7eed\u62d3\u5c55\uff0c\u589e\u957f16%\u3002\u516c\u53f8\u65b0\u63a8\u51fa\u4e86\u4e00\u6b3e\u4fdd\u62a4\u725b\u7f8a\u514d\u53d7\u8840\u6e053\u578b\u84dd\u820c\u75c5\u75c5\u6bd2\uff08BTV-3\uff09\u611f\u67d3\u7684\u65b0\u75ab\u82d7\uff1aBULTAVO 3&#x2122;\u3002\u8fd9\u662f\u9996\u4e2a\u80fd\u591f\u9884\u9632\u4e34\u5e8a\u75c7\u72b6\u4e0e\u6b7b\u4ea1\u7684BTV-3\u75ab\u82d7\u3002\u76ee\u524dBULTAVO 3&#x2122; \u5df2\u5728\u8377\u5170\u3001\u6bd4\u5229\u65f6\u548c\u5fb7\u56fd\u83b7\u5f97\u7d27\u6025\u4f7f\u7528\u8bb8\u53ef\u3002\u8fd1\u671f\u8fd9\u4e09\u4e2a\u56fd\u5bb6\u7206\u53d1\u7684BTV-3\u75ab\u60c5\u7ed9\u5f53\u5730\u519c\u573a\u4e3b\u9020\u6210\u4e25\u91cd\u635f\u5931\uff0c\u5e76\u5bf9\u90bb\u56fd\u6784\u6210\u5a01\u80c1\u3002<\/p>\n<p>\u4eca\u5e74\u4e0a\u534a\u5e74\uff0c\u52a8\u7269\u4fdd\u5065\u4e1a\u52a1\u589e\u957f\u4f4e\u4e8e\u9884\u671f\uff0c\u51c0\u9500\u552e\u989d\u540c\u6bd4\u589e\u957f0.9%*\u81f325\u4ebf\u6b27\u5143\u3002<\/p>\n<p>\u968f\u7740\u72ac\u7528NEXGARD PLUS\u548c\u732b\u7528NEXGARD COMBO\u7684\u6700\u65b0\u4e0a\u5e02\uff0c\u5c3c\u53ef\u4fe1<sup>&reg;<\/sup>\u7cfb\u5217\u6297\u5bc4\u751f\u866b\u4ea7\u54c1\u7684\u51c0\u9500\u552e\u989d\u540c\u6bd4\u589e\u957f16%\u3002\u4f5c\u4e3a\u9996\u4e2a\u83b7\u6279\u7684\u72ac\u7528\u6297\u8731\u866b\u4e0e\u8df3\u86a4\u975e\u5904\u65b9\u5480\u56bc\u7247\uff0cFRONTPRO<sup>&reg;<\/sup>\u73b0\u5df2\u5728\u6b27\u6d32\u5927\u591a\u6570\u56fd\u5bb6\u4e0a\u5e02\uff0c\u5e76\u6301\u7eed\u63a8\u52a8\u8be5\u533a\u57df\u4e1a\u7ee9\u589e\u957f\u3002\u5728\u5ba0\u7269\u6cbb\u7597\u4ea7\u54c1\u9886\u57df\uff0c\u72ac\u7528\u5145\u8840\u6027\u5fc3\u8870\u6cbb\u7597\u836f\u7269\u52c3\u6b23\u5b9a\u7684\u51c0\u9500\u552e\u989d\u540c\u6bd4\u589e\u957f16%\u3002<\/p>\n<p><b>\u7ba1\u7ebf\u5c55\u671b<\/b><\/p>\n<p>\u5c55\u671b\u672a\u6765\uff0c\u4eba\u7528\u836f\u54c1\u4e1a\u52a1\u9884\u8ba1\u52302030\u5e74\u5c06\u6536\u83b7\u591a\u8fbe25\u9879\u83b7\u6279\u4e0a\u5e02\u6210\u679c\u3002\u52a8\u7269\u4fdd\u5065\u4e1a\u52a1\u9884\u8ba1\u52302026\u5e74\u4e5f\u5c06\u4e8e\u5404\u5730\u5e02\u573a\u6536\u83b720\u9879\u65b0\u6ce8\u518c\u4e0a\u5e02\u6210\u679c\uff0c\u5305\u62ec\u4ea7\u54c1\u8fed\u4ee3\u3001\u9002\u5e94\u75c7\u62d3\u5c55\u548c\u65b0\u4ea7\u54c1\u4e0a\u5e02\u3002<\/p>\n<p>* \u7ecf\u6c47\u7387\u8c03\u6574\u540e<\/p>\n<p><b>\u53c2\u8003\u6587\u732e<\/b>\uff1a<\/p>\n<div>\n<table border=\"0\" cellspacing=\"0\" cellpadding=\"1\" class=\"prnbcc\">\n<tbody>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\"><sup>1&nbsp;<\/sup>Sanyal, Arun J. &quot;Glucagon and GLP-1 receptor dual agonist survodutide improved liver histology in people with MASH and fibrosis: Results from a randomized, double-blind, placebo-controlled phase 2 trial&quot;. Oral presentation at European Association for the Study of the Liver Congress, Milan, Italy. 7June 2024. Abstract #LB117, presentation #GS-006.<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\"><sup>2 <\/sup>Heymach, John. &quot;Phase Ia\/Ib trial of zongertinib (BI 1810631), a HER2-specific tyrosine kinase inhibitor in patients with HER2 aberration-positive solid tumors: updated Phase Ia data from Beamion LUNG-1, including progression-free survival data\u201d. Oral presentation at American Society of Clinical Oncology, United States, Chicago. 1 June 2024. Abstract #8514<\/span><\/p>\n<p class=\"prnml4\">&nbsp;<\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table><\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u516c\u53f8\u5728\u5fc3\u80be\u4ee3\u8c22\u5065\u5eb7\u4e0e\u80bf\u7624\u9886\u57df\u8fbe\u6210\u591a\u9879\u91cc\u7a0b\u7891 \u5e74\u5185\u80bf\u7624\u3001\u7cbe\u795e\u5065\u5eb7\u4e0e\u80ba\u7ea4\u7ef4\u5316\u9886\u57df\u7684\u4e34\u5e8a\u7814\u7a76\u5c06\u53d1\u5e03\u6700\u65b0\u6570\u636e \u4e0a\u534a\u5e74\u51c0\u9500\u552e\u989d\u540c\u6bd4\u5b9e\u73b07.4%*\u7684\u5f3a\u52b2\u589e\u957f \u4e0a\u6d772024\u5e747\u670818\u65e5 \/\u7f8e\u901a\u793e\/ &#8212; 7\u670818\u65e5\uff0c\u4ee5\u7814\u53d1\u9a71\u52a8\u7684\u5168\u7403\u751f\u7269\u5236\u836f\u9886\u519b\u4f01\u4e1a\u52c3\u6797\u683c\u6bb7\u683c\u7ff0\u53d1\u5e03\u4e862024\u5e74\u4e0a\u534a\u5e74\u4e1a\u7ee9\u3002\u4eca\u5e74\u4e0a\u534a\u5e74\uff0c\u516c\u53f8\u5927\u5e45\u52a0\u901f\u63a8\u8fdb\u5173\u952e\u6cbb\u7597\u9886\u57df\u7684\u4ea7\u54c1\u7ba1\u7ebf\uff0c\u8fbe\u6210\u591a\u9879\u91cd\u8981\u91cc\u7a0b\u7891\u3002 \u52c3\u6797\u683c\u6bb7\u683c\u7ff0\u5168\u7403\u6267\u884c\u8463\u4e8b\u4f1a\u4e3b\u5e2d\u51af\u4fdd\u548c\uff08Hubertus von Baumbach\uff09\u5148\u751f\u8868\u793a\uff1a&quot;\u6211\u4eec\u57284\u6708\u516c\u5e03\u7684\u516c\u53f8\u7814\u53d1\u89c4\u5212\u7684\u57fa\u7840\u4e0a\uff0c\u8fdb\u4e00\u6b65\u52a0\u5927\u7814\u53d1\u6295\u5165\u3002\u9488\u5bf9\u4ee3\u8c22\u529f\u80fd\u969c\u788d\u76f8\u5173\u7684\u8102\u80aa\u6027\u809d\u708e\uff0c\u6211\u4eec\u5df2\u516c\u5e03\u4e86\u632f\u594b\u4eba\u5fc3\u7684\u7814\u7a76\u6570\u636e\u3002\u63a5\u4e0b\u6765\uff0c\u6211\u4eec\u8fd8\u5c06\u53d1\u5e03\u80bf\u7624\u3001\u7cbe\u795e\u5065\u5eb7\u4e0e\u80ba\u7ea4\u7ef4\u5316\u9886\u57df\u7684\u6700\u65b0\u7814\u7a76\u7ed3\u679c\u3002\u8fd9\u4e9b\u65b0\u8fdb\u5c55\u7ed9\u4e88\u4e86\u6211\u4eec\u5145\u8db3\u4fe1\u5fc3\uff0c\u52a0\u901f\u63a8\u52a8\u8fd9\u4e9b\u665a\u671f\u5728\u7814\u836f\u7269\u4e0a\u5e02\u524d\u51c6\u5907\u3002\u6211\u4eec\u975e\u5e38\u9ad8\u5174\u770b\u5230\u516c\u53f8\u4ea7\u54c1\u7ba1\u7ebf\u98de\u901f\u53d1\u5c55\u3002&quot; \u52c3\u6797\u683c\u6bb7\u683c\u7ff0\u6301\u7eed\u63a8\u8fdb\u5904\u5728\u4e0d\u540c\u4e34\u5e8a\u8bd5\u9a8c\u9636\u6bb5\u7684\u7814\u53d1\u7ba1\u7ebf\u3002\u4e0a\u534a\u5e74\uff0c\u516c\u53f8\u5728\u5fc3\u8840\u7ba1\u4ee3\u8c22\u75be\u75c5\u3001\u7cbe\u795e\u5065\u5eb7\u4e0e\u80bf\u7624\u9886\u57df\u542f\u52a8\u4e865\u9879\u65b0\u7684I\u671f\u3001II\u671f\u6216III\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff1b\u5728\u708e\u75c7\u6027\u75be\u75c5\u9886\u57df\uff0c\u516c\u53f8\u7684\u5728\u7814\u4ea7\u54c1\u4e5f\u6210\u529f\u83b7\u5f972\u9879\u5feb\u901f\u901a\u9053\u8d44\u683c\u8ba4\u5b9a\u3002\u4e0e\u6b64\u540c\u65f6\uff0c\u516c\u53f8\u5ba3\u5e03\u8fbe\u62109\u9879\u7814\u53d1\u5408\u4f5c\u534f\u8bae\uff0c\u8986\u76d6\u5404\u6cbb\u7597\u9886\u57df\u4e0e\u6280\u672f\u5e73\u53f0\uff0c\u6781\u5927\u589e\u5f3a\u4e86\u516c\u53f8\u7684\u4eba\u7528\u836f\u54c1\u4ea7\u54c1\u7ec4\u5408\u3002 \u52c3\u6797\u683c\u6bb7\u683c\u7ff0\u5168\u7403\u6267\u884c\u8463\u4e8b\u4f1a\u6210\u5458\u3001\u8d22\u52a1\u8d1f\u8d23\u4ebaFrank H&uuml;bler\u8868\u793a\uff1a&quot;\u968f\u7740\u6211\u4eec\u7814\u53d1\u7ba1\u7ebf\u5728\u6df1\u5ea6\u4e0e\u5e7f\u5ea6\u6301\u7eed\u62d3\u5c55\uff0c\u6211\u4eec\u5728\u8d44\u6e90\u914d\u7f6e\u65f6\u4fdd\u6301\u9ad8\u5ea6\u4e13\u6ce8\u3002\u6211\u4eec\u5e0c\u671b\u7aed\u5c3d\u6240\u80fd\u52a0\u901f\u4ea7\u54c1\u7814\u53d1\uff0c\u5c06\u6211\u4eec\u7684\u521b\u65b0\u836f\u54c1\u66f4\u5feb\u60e0\u53ca\u60a3\u8005\u3002&quot; \u5728\u6301\u7eed\u5f3a\u52b2\u7684\u5e02\u573a\u9700\u6c42\u62c9\u52a8\u4e0b\uff0c2024\u5e74\u4e0a\u534a\u5e74\u516c\u53f8\u51c0\u9500\u552e\u989d\u540c\u6bd4\u589e\u957f7.4%*\u81f3129\u4ebf\u6b27\u5143\uff0c\u5305\u62ec\u4eba\u7528\u836f\u54c1\u4e1a\u52a1\u7684\u6b27\u5510\u9759&reg;\u5bb6\u65cf\u4e0e\u7ef4\u52a0\u7279&reg;\uff0c\u4ee5\u53ca\u52a8\u7269\u4fdd\u5065\u4e1a\u52a1\u7684\u5c3c\u53ef\u4fe1&reg;\u5bb6\u65cf\u4ea7\u54c1\u7b49\u5728\u5185\u7684\u591a\u4e2a\u52c3\u6797\u683c\u4ea7\u54c1\u9a71\u52a8\u589e\u957f\u3002 \u4eba\u7528\u836f\u54c1\u4e1a\u52a1 \u52c3\u6797\u683c\u6bb7\u683c\u7ff0\u79ef\u6781\u4e3a\u672a\u6765\u4ea7\u54c1\u7ec4\u5408\u4ee5\u53ca\u5373\u5c06\u4e0a\u5e02\u7684\u4ea7\u54c1\u505a\u51c6\u5907\u3002\u8fc7\u53bb\u51e0\u4e2a\u6708\uff0c\u516c\u53f8\u5728\u6240\u6709\u91cd\u70b9\u6cbb\u7597\u9886\u57df\u90fd\u53d6\u5f97\u8fdb\u5c55\u3002\u5e74\u5185\uff0c\u516c\u53f8\u8fd8\u5c06\u53d1\u5e03\u80bf\u7624\uff08Zongertinib\uff09\u3001\u7cbe\u795e\u5065\u5eb7\uff08Iclepertin\uff09\u4e0e\u80ba\u7ea4\u7ef4\u5316\uff08Nerandomilast\uff09\u9886\u57df\u4e34\u5e8a\u7814\u7a76\u7684\u66f4\u591a\u6700\u65b0\u7ed3\u679c\u3002 \u516c\u53f8\u5728\u4fc3\u8fdb\u6574\u4f53\u5fc3\u80be\u810f\u4ee3\u8c22 (CRM) \u5065\u5eb7\u65b9\u9762\u7684\u7814\u7a76\u52aa\u529b\u8fbe\u6210\u4e00\u7cfb\u5217\u91cd\u8981\u91cc\u7a0b\u7891\u3002\u5176\u4e2d\uff0csurvodutide\u6cbb\u7597\u4ee3\u8c22\u529f\u80fd\u969c\u788d\u76f8\u5173\u7684\u8102\u80aa\u6027\u809d\u708e\uff08MASH\uff09\u7684II\u671f\u4e34\u5e8a\u8bd5\u9a8c\u53d6\u5f97\u7a81\u7834\u6027\u7684\u79ef\u6781\u7ed3\u679c\uff1a\u4e0e\u5b89\u6170\u5242(18.2%)\u76f8\u6bd4\uff0c\u9ad8\u8fbe83%\u63a5\u53d7survodutide\u6cbb\u7597\u7684MASH\u6210\u4eba\u60a3\u8005\u5b9e\u73b0\u4e86\u5177\u6709\u7edf\u8ba1\u5b66\u610f\u4e49\u7684\u6539\u5584[\u7ec4\u95f4\u5dee\u5f02\uff1a64.8%\uff0c(CI 51.1% &#8211; 78.6%), p&lt;0.0001]\u3002\u6b64\u5916\uff0c\u8be5\u8bd5\u9a8c\u4e00\u9879\u4e9a\u7ec4\u5206\u6790\u7ed3\u679c\u663e\u793a\uff0c\u4e0e\u5b89\u6170\u5242(25.9%)\u76f8\u6bd4\uff0c\u591a\u8fbe64.5%\u7684F2\u548cF3\u671f\u7ea4\u7ef4\u5316\uff08\u4e2d\u5ea6\u81f3\u665a\u671f\u75a4\u75d5\uff09\u6210\u4eba\u60a3\u8005\u7684\u7ea4\u7ef4\u5316\u7a0b\u5ea6\u5f97\u5230\u6539\u5584\uff0c\u4e14MASH\u65e0\u6076\u5316 [\u7ec4\u95f4\u5dee\u5f02\uff1a38.6%\uff0c(95% CI 18.1% &#8211; 59.1%), p=0.0005]\u3002[1] \u516c\u53f8\u542f\u52a8\u4e86\u4e00\u9879\u65b0\u578b\u9009\u62e9\u6027\u919b\u56fa\u916e\u5408\u9176\u6291\u5236\u5242\uff08ASi\uff09\u8054\u5408\u6069\u683c\u5217\u51c0\u6cbb\u7597\u6162\u6027\u5fc3\u529b\u8870\u7aed\u60a3\u8005\u7684III\u671f\u4e34\u5e8a\u8bd5\u9a8c\u3002\u52c3\u6797\u683c\u6bb7\u683c\u7ff0\u8fd8\u5c06\u4e0e\u725b\u6d25\u4eba\u53e3\u5065\u5eb7\u4e2d\u5fc3\u5408\u4f5c\uff0c\u5f00\u5c55\u4e00\u9879\u4f7f\u7528Asi\u6cbb\u7597\u6162\u6027\u80be\u75c5\u7684III\u671f\u4e34\u5e8a\u8bd5\u9a8c\u3002 \u6b64\u5916\uff0c\u52c3\u6797\u683c\u6bb7\u683c\u7ff0\u5df2\u4e0e\u7f8e\u56fd\u5fc3\u810f\u534f\u4f1a\u5fc3\u80be\u4ee3\u8c22\u5065\u5eb7\u5021\u8bae\u8fbe\u6210\u591a\u5e74\u8d5e\u52a9\u534f\u8bae\u3002\u8fd9\u4e00\u6700\u65b0\u5ba3\u5e03\u7684\u4e3e\u63aa\u5c06\u5e2e\u52a9\u516c\u53f8\u66f4\u597d\u5730\u4e86\u89e3\u5fc3\u80be\u4ee3\u8c22\u5173\u8054\u6027\u75be\u75c5\u60a3\u8005\u7684\u8d1f\u62c5\uff0c\u4ece\u800c\u63d0\u4f9b\u66f4\u597d\u7684\u6cbb\u7597\u65b9\u6848\u3002 \u52c3\u6797\u683c\u6bb7\u683c\u7ff0\u81f4\u529b\u4e8e\u901a\u8fc7\u5b9a\u5411\u6295\u8d44\u91cd\u8fd4\u80bf\u7624\u6cbb\u7597\u9886\u57df\u3002HER2\u7279\u5f02\u6027\u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5242Zongertinib\u6cbb\u7597HER2 \u53d8\u5f02\u9633\u6027\u5b9e\u4f53\u7624\u60a3\u8005\u7684Ia\/Ib\u671f\u8bd5\u9a8c\u7ed3\u679c\u8868\u660e\uff0cZongertinib\u5c55\u73b0\u51fa\u826f\u597d\u7684\u8010\u53d7\u6027\u4e0e\u663e\u8457\u7684\u6709\u6548\u6027[2]\u3002\u6b64\u5916\uff0c\u5c3d\u7ba1Brigimadlin\u6cbb\u7597\u53bb\u5206\u5316\u8102\u80aa\u8089\u7624\u7684Brightline-1\u4e34\u5e8a\u8bd5\u9a8c\u672a\u8fbe\u5230\u4e3b\u8981\u7ec8\u70b9\uff0c\u4f46\u83b7\u76ca-\u98ce\u9669\u8bc4\u4f30\u7ed3\u679c\u4ecd\u4e3a\u9633\u6027\u3002\u5b8c\u6574\u7684\u8bd5\u9a8c\u7ed3\u679c\u5c06\u4e8e\u5e74\u5185\u665a\u4e9b\u7684\u533b\u5b66\u4f1a\u8bae\u4e0a\u516c\u5e03\u3002\u8fd9\u4e24\u9879\u4e34\u5e8a\u8bd5\u9a8c\u7ed3\u679c\u5c06\u4e8e\u8fd1\u51e0\u4e2a\u6708\u7684\u533b\u5b66\u4f1a\u8bae\u4e0a\u516c\u5e03\u3002 2024\u5e74\u4e0a\u534a\u5e74\uff0c\u52c3\u6797\u683c\u6bb7\u683c\u7ff0\u4eba\u7528\u836f\u54c1\u4e1a\u52a1\u51c0\u9500\u552e\u989d\u540c\u6bd4\u589e\u957f9.3%*\u8fbe103\u4ebf\u6b27\u5143\uff0c\u4e3b\u8981\u5f97\u76ca\u4e8e\u6b27\u5510\u9759&reg;\u5bb6\u65cf\u548c\u7ef4\u52a0\u7279&reg;\u7684\u5f3a\u52b2\u8868\u73b0\u3002\u4e3a\u4e86\u6ee1\u8db3\u4e0d\u65ad\u589e\u957f\u7684\u5e02\u573a\u9700\u6c42\uff0c\u52c3\u6797\u683c\u6bb7\u683c\u7ff0\u5bf9\u751f\u4ea7\u4e0e\u4f9b\u5e94\u7f51\u7edc\u6301\u7eed\u9ad8\u4f4d\u6295\u8d44\u3002\u4eca\u5e741\u6708\uff0c\u52c3\u6797\u683c\u6bb7\u683c\u7ff0\u5ba3\u5e03\u6295\u8d441.2\u4ebf\u6b27\u5143\u5347\u7ea7\u6269\u5efa\u4f4d\u4e8e\u5e0c\u814aKoropi\u7684\u5de5\u5382\uff0c\u65e8\u5728\u63d0\u5347\u65b0\u4e0a\u5e02\u4e0e\u73b0\u6709\u836f\u54c1\u7684\u4ea7\u80fd\uff0c\u5305\u62ec\u5904\u4e8e\u665a\u671f\u5f00\u53d1\u9636\u6bb5\u7684\u4e00\u4e9b\u5728\u7814\u4ea7\u54c1\u3002 \u52a8\u7269\u4fdd\u5065\u4e1a\u52a1 \u5728\u755c\u79bd\u4e1a\u52a1\u9886\u57df\uff0c\u5bb6\u79bd\u75ab\u82d7VAXXITEK\u4ea7\u54c1\u7ec4\u5408\u6301\u7eed\u62d3\u5c55\uff0c\u589e\u957f16%\u3002\u516c\u53f8\u65b0\u63a8\u51fa\u4e86\u4e00\u6b3e\u4fdd\u62a4\u725b\u7f8a\u514d\u53d7\u8840\u6e053\u578b\u84dd\u820c\u75c5\u75c5\u6bd2\uff08BTV-3\uff09\u611f\u67d3\u7684\u65b0\u75ab\u82d7\uff1aBULTAVO 3&#x2122;\u3002\u8fd9\u662f\u9996\u4e2a\u80fd\u591f\u9884\u9632\u4e34\u5e8a\u75c7\u72b6\u4e0e\u6b7b\u4ea1\u7684BTV-3\u75ab\u82d7\u3002\u76ee\u524dBULTAVO 3&#x2122; \u5df2\u5728\u8377\u5170\u3001\u6bd4\u5229\u65f6\u548c\u5fb7\u56fd\u83b7\u5f97\u7d27\u6025\u4f7f\u7528\u8bb8\u53ef\u3002\u8fd1\u671f\u8fd9\u4e09\u4e2a\u56fd\u5bb6\u7206\u53d1\u7684BTV-3\u75ab\u60c5\u7ed9\u5f53\u5730\u519c\u573a\u4e3b\u9020\u6210\u4e25\u91cd\u635f\u5931\uff0c\u5e76\u5bf9\u90bb\u56fd\u6784\u6210\u5a01\u80c1\u3002 \u4eca\u5e74\u4e0a\u534a\u5e74\uff0c\u52a8\u7269\u4fdd\u5065\u4e1a\u52a1\u589e\u957f\u4f4e\u4e8e\u9884\u671f\uff0c\u51c0\u9500\u552e\u989d\u540c\u6bd4\u589e\u957f0.9%*\u81f325\u4ebf\u6b27\u5143\u3002 \u968f\u7740\u72ac\u7528NEXGARD PLUS\u548c\u732b\u7528NEXGARD COMBO\u7684\u6700\u65b0\u4e0a\u5e02\uff0c\u5c3c\u53ef\u4fe1&reg;\u7cfb\u5217\u6297\u5bc4\u751f\u866b\u4ea7\u54c1\u7684\u51c0\u9500\u552e\u989d\u540c\u6bd4\u589e\u957f16%\u3002\u4f5c\u4e3a\u9996\u4e2a\u83b7\u6279\u7684\u72ac\u7528\u6297\u8731\u866b\u4e0e\u8df3\u86a4\u975e\u5904\u65b9\u5480\u56bc\u7247\uff0cFRONTPRO&reg;\u73b0\u5df2\u5728\u6b27\u6d32\u5927\u591a\u6570\u56fd\u5bb6\u4e0a\u5e02\uff0c\u5e76\u6301\u7eed\u63a8\u52a8\u8be5\u533a\u57df\u4e1a\u7ee9\u589e\u957f\u3002\u5728\u5ba0\u7269\u6cbb\u7597\u4ea7\u54c1\u9886\u57df\uff0c\u72ac\u7528\u5145\u8840\u6027\u5fc3\u8870\u6cbb\u7597\u836f\u7269\u52c3\u6b23\u5b9a\u7684\u51c0\u9500\u552e\u989d\u540c\u6bd4\u589e\u957f16%\u3002 \u7ba1\u7ebf\u5c55\u671b \u5c55\u671b\u672a\u6765\uff0c\u4eba\u7528\u836f\u54c1\u4e1a\u52a1\u9884\u8ba1\u52302030\u5e74\u5c06\u6536\u83b7\u591a\u8fbe25\u9879\u83b7\u6279\u4e0a\u5e02\u6210\u679c\u3002\u52a8\u7269\u4fdd\u5065\u4e1a\u52a1\u9884\u8ba1\u52302026\u5e74\u4e5f\u5c06\u4e8e\u5404\u5730\u5e02\u573a\u6536\u83b720\u9879\u65b0\u6ce8\u518c\u4e0a\u5e02\u6210\u679c\uff0c\u5305\u62ec\u4ea7\u54c1\u8fed\u4ee3\u3001\u9002\u5e94\u75c7\u62d3\u5c55\u548c\u65b0\u4ea7\u54c1\u4e0a\u5e02\u3002 * \u7ecf\u6c47\u7387\u8c03\u6574\u540e \u53c2\u8003\u6587\u732e\uff1a 1&nbsp;Sanyal, Arun J. &quot;Glucagon and GLP-1 receptor&hellip; <a class=\"read-more\" href=\"https:\/\/www.xinwengao.com\/cn\/pr\/20240718145100114865\">Read More<\/a><\/p>\n","protected":false},"author":556,"featured_media":114868,"comment_status":"close","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1965],"tags":[],"class_list":["post-114865","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-partnerships"],"amp_enabled":true,"_links":{"self":[{"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/posts\/114865","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/users\/556"}],"replies":[{"embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/comments?post=114865"}],"version-history":[{"count":1,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/posts\/114865\/revisions"}],"predecessor-version":[{"id":114867,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/posts\/114865\/revisions\/114867"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/media\/114868"}],"wp:attachment":[{"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/media?parent=114865"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/categories?post=114865"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/tags?post=114865"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}