{"id":114631,"date":"2024-07-16T07:53:00","date_gmt":"2024-07-16T00:53:00","guid":{"rendered":"https:\/\/www.xinwengao.com\/cn\/pr\/20240716075300114631"},"modified":"2024-07-17T11:37:57","modified_gmt":"2024-07-17T03:37:57","slug":"%e5%9b%bd%e9%99%85%e9%a6%96%e6%ac%a1%ef%bc%81%e9%82%a6%e8%80%80%e7%94%9f%e7%89%a9ucar-t%e7%a0%94%e7%a9%b6%e6%88%90%e6%9e%9c%e8%8d%a3%e7%99%bbcell%ef%bc%8c%e8%81%9a%e7%84%a6%e8%87%aa%e5%85%8d%e7%96%be","status":"publish","type":"post","link":"https:\/\/www.xinwengao.com\/cn\/pr\/20240716075300114631","title":{"rendered":"\u56fd\u9645\u9996\u6b21\uff01\u90a6\u8000\u751f\u7269UCAR-T\u7814\u7a76\u6210\u679c\u8363\u767bCell\uff0c\u805a\u7126\u81ea\u514d\u75be\u75c5\u6cbb\u7597\u53d6\u5f97\u91cd\u5927\u7a81\u7834"},"content":{"rendered":"\n\n\n
\"\"<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

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\u4e0a\u6d772024\u5e747\u670816\u65e5 \/\u7f8e\u901a\u793e\/ — \u805a\u7126\u4e8e\u57fa\u56e0\u548c\u7ec6\u80de\u6cbb\u7597\u7684\u4e0a\u6d77\u90a6\u8000\u751f\u7269\u79d1\u6280\u6709\u9650\u516c\u53f8\uff08\u4ee5\u4e0b\u7b80\u79f0"\u90a6\u8000\u751f\u7269"\uff09\u5ba3\u5e03\uff0c\u5176\u4e0e\u534e\u4e1c\u5e08\u8303\u5927\u5b66\u3001\u4e0a\u6d77\u957f\u5f81\u533b\u9662\u5408\u4f5c\u7684\u65b0\u4e00\u4ee3\u5f02\u4f53\u901a\u7528\u578b<\/b>CAR-T\u7597\u6cd5\uff08TyU19\uff09\u6cbb\u7597\u81ea\u8eab\u514d\u75ab\u75be\u75c5\u7814\u7a76\u6210\u679c\u4e8e7\u670815\u65e5\u6b63\u5f0f\u5728\u56fd\u9645\u9876\u7ea7\u5b66\u672f\u671f\u520aCell<\/i>\u4e0a\u53d1\u8868\uff0c<\/b>\u8bba\u6587\u9898\u4e3a"<\/b>Allogeneic CD19-targeted CAR-T therapy in patients with severe myositis and systemic sclerosis"<\/b>\uff0c\u90a6\u8000\u751f\u7269\u751f\u4ea7\u4e0e<\/b>CMC\u526f\u603b\u88c1\u8c2d\u70b3\u5408\u535a\u58eb\u4e3a\u8bba\u6587\u5171\u540c\u7b2c\u4e00\u4f5c\u8005\uff0c\u4ee5\u53ca\u90a6\u8000\u751f\u7269\u521b\u59cb\u4eba&\u8463\u4e8b\u957f\u5218\u660e\u8000\u6559\u6388\u3001\u8054\u5408\u521b\u59cb\u4eba\uff06\u526f\u603b\u88c1\u675c\u51b0\u6559\u6388\u4e3a\u8bba\u6587\u5171\u540c\u901a\u8baf\u4f5c\u8005\u3002<\/b>\u503c\u5f97\u4e00\u63d0\u7684\u662f\uff0c\u8fd9\u662f\u56fd\u9645\u4e0a\u9996\u6b21\u62a5\u9053\u5f02\u4f53\u901a\u7528\u578b<\/b>CAR-T\u5728\u6cbb\u7597\u81ea\u8eab\u514d\u75ab\u75be\u75c5\u4e2d\u83b7\u5f97\u6210\u529f\uff0c\u4e5f\u662f\u9876\u7ea7\u671f\u520aCell\u9996\u6b21\u53d1\u8868CAR-T\u6cbb\u7597\u81ea\u514d\u75be\u75c5\u7684\u7814\u7a76\u6210\u679c\u3002<\/b>\u65e2\u4ee3\u8868\u90a6\u8000\u751f\u7269\u5728CAR-T\u5c24\u5176\u662f\u5f02\u4f53\u901a\u7528\u578bCAR-T\u6cbb\u7597\u81ea\u8eab\u514d\u75ab\u75be\u75c5\u9886\u57df\u83b7\u5f97\u4e86\u5173\u952e\u6027\u7a81\u7834\uff0c\u4e5f\u610f\u5473\u7740\u90a6\u8000\u751f\u7269\u5728\u7ec6\u80de\u548c\u57fa\u56e0\u6cbb\u7597\u9886\u57df\u7684\u6280\u672f\u5dee\u5f02\u5316\u521b\u65b0\u65b9\u9762\u5b9e\u73b0\u4e86\u8d28\u7684\u98de\u8dc3\u3002<\/p>\n

\n

\"\u90a6\u8000\u751f\u7269cell\u53d1\u6587\uff08\u8bba\u6587\u94fe\u63a5\uff1ahttps:\/\/doi.org\/10.1016\/j.cell.2024.06.027\uff09\"<\/a>
\u90a6\u8000\u751f\u7269cell\u53d1\u6587\uff08\u8bba\u6587\u94fe\u63a5\uff1ahttps:\/\/doi.org\/10.1016\/j.cell.2024.06.027\uff09<\/span><\/p>\n<\/p><\/div>\n

\u5728\u6b64\u9879\u7814\u7a76\u4e2d\uff0cTyU19\u662f\u90a6\u8000\u751f\u7269\u57fa\u4e8e\u5177\u6709\u81ea\u4e3b\u77e5\u8bc6\u4ea7\u6743\u7684\u901a\u7528\u578b\u7ec6\u80de\u5e73\u53f0\uff08TyUCell®<\/sup>\uff09\u5f00\u53d1\u7684\u9776\u5411CD19\u6297\u539f\u7684\u5f02\u4f53\u901a\u7528\u578bCAR-T\u7ec6\u80de\u6cbb\u7597\u4ea7\u54c1\uff0c\u5177\u6709\u53ef\u53ca\u6027\u9ad8\u3001\u6210\u672c\u4f4e\u3001\u8d28\u91cf\u7a33\u5b9a\u7b49\u8bf8\u591a\u7279\u70b9\uff0c\u5728\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u4f53\u73b0\u51fa\u4e86\u663e\u8457\u7684\u7597\u6548\u548c\u9ad8\u5b89\u5168\u6027\u3002\u503c\u5f97\u5e86\u8d3a\u7684\u662f\uff0c\u6b64\u524d\u90a6\u8000\u751f\u7269\u4f9d\u6258\u8be5\u4ea7\u54c1\u7684"\u9776\u5411CD19\u57fa\u56e0\u4fee\u9970\u7684\u5f02\u4f53\u5d4c\u5408\u6297\u539f\u53d7\u4f53T\u7ec6\u80de\u6ce8\u5c04\u6db2"\uff08\u7ba1\u7ebf\u4ee3\u53f7\uff1aBRL-301\uff09\u7684\u4e34\u5e8a\u8bd5\u9a8c\u7533\u8bf7\uff08<\/b>IND\uff09\u5df2\u4e8e2023\u5e747\u6708\u83b7\u5f97\u4e2d\u56fd\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u836f\u54c1\u5ba1\u8bc4\u4e2d\u5fc3\uff08CDE\uff09\u7684\u6279\u51c6\uff0c<\/b>\u7528\u4e8e\u6cbb\u7597"B\u6025\u6027\u6dcb\u5df4\u7ec6\u80de\u767d\u8840\u75c5"\uff1b\u800c\u6b64\u6b21<\/b>Cell<\/i>\u6742\u5fd7\u4ee5Article\u5f62\u5f0f\u53d1\u8868\u7684\u7814\u7a76\u6210\u679c\u5219\u662f\u90a6\u8000\u751f\u7269\u5168\u65b0\u4e00\u4ee3UCAR-T\u4ea7\u54c1TyU19\u5e94\u7528\u7684\u53e6\u4e00\u5927\u91cd\u8981\u573a\u666f\u2014\u2014"\u81ea\u8eab\u514d\u75ab\u75be\u75c5"\u3002<\/b><\/p>\n

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\n

\"\u56fe1<\/a>
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\n

\"\u56fe2<\/a>
\u56fe2 IMNM\u60a3\u8005\u4e34\u5e8a\u8bc4\u4f30<\/span><\/p>\n<\/p><\/div>\n

 <\/p>\n

\n

\"\u56fe3<\/a>
\u56fe3 SSc\u60a3\u8005\u4e34\u5e8a\u8bc4\u4f30<\/span><\/p>\n<\/p><\/div>\n

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"\u5f02\u4f53\u901a\u7528\u578bCAR-T\u7684\u5f00\u53d1\u4e00\u76f4\u662f\u4e1a\u5185\u9762\u4e34\u7684\u6700\u5927\u6280\u672f\u6311\u6218\uff0c\u73b0\u6709\u7684\u57fa\u56e0\u7f16\u8f91\u7b56\u7565\u53ef\u4ee5\u6709\u6548\u5730\u7834\u574fTCR\u7ed3\u6784\u4ece\u800c\u907f\u514d\u60a3\u8005\u51fa\u73b0\u79fb\u690d\u7269\u6297\u5bbf\u4e3b\u75c5\uff08GvHD\uff09\uff0c\u4f46\u662f\u5bf9\u4e8e\u5f02\u4f53CAR-T\u7ec6\u80de\u5728\u60a3\u8005\u4f53\u5185\u6240\u9762\u4e34\u7684\u6392\u5f02\u95ee\u9898\u5374\u59cb\u7ec8\u5f97\u4e0d\u5230\u6709\u6548\u89e3\u51b3\u3002\u4f20\u7edf\u7684\u5f02\u4f53\u901a\u7528\u578bCAR-T\u5728\u4e34\u5e8a\u4e2d\u59cb\u7ec8\u5b58\u5728\u8fc7\u5ea6\u514d\u75ab\u6291\u5236\u7ed9\u60a3\u8005\u5e26\u6765\u7684\u5de8\u5927\u611f\u67d3\u98ce\u9669\u4ee5\u53ca\u4f53\u5185\u5b58\u7559\u65f6\u95f4\u77ed\u3001\u6709\u6548\u6027\u4e0d\u4f73\u7b49\u95ee\u9898\uff0c\u6781\u5927\u9650\u5236\u4e86\u5176\u4e34\u5e8a\u53ef\u53ca\u6027\u3002\u672c\u9879\u76ee\u7814\u7a76\u56e2\u961f\u5386\u7ecf8\u5e74\u7684\u6f5c\u5fc3\u7814\u7a76\u548c\u523b\u82e6\u653b\u5173\uff0c\u7528\u57fa\u56e0\u7f16\u8f91\u6280\u672f\u6709\u6548\u89e3\u51b3\u4e86\u4e0a\u8ff0\u95ee\u9898\uff0c\u5f00\u53d1\u7684TyU19\u5728\u4f7f\u7528\u6bd4\u81ea\u4f53CAR-T\u66f4\u4f4e\u7684FC\u9884\u5904\u7406\u6761\u4ef6\u4e0b\uff0c\u5728\u60a3\u8005\u4f53\u5185\u5b9e\u73b0\u4e86\u957f\u671f\u5b58\u7559\u548c\u6709\u6548\u6740\u4f24\uff0c\u5b89\u5168\u6027\u3001\u6709\u6548\u6027\u7b49\u5404\u65b9\u9762\u6307\u6807\u8fbe\u5230\u751a\u81f3\u8d85\u8fc7\u4e86\u4f20\u7edf\u81ea\u4f53CAR-T\uff0c\u8fd9\u4e5f\u662fTyU19\u80fd\u591f\u6210\u4e3a\u56fd\u9645\u4e0a\u9996\u4e2a\u6210\u529f\u6cbb\u7597\u81ea\u8eab\u514d\u75ab\u6027\u75be\u75c5\u7684\u5f02\u4f53\u901a\u7528\u578bCAR-T\u7684\u6700\u91cd\u8981\u539f\u56e0\u3002"\u8bba\u6587\u5171\u540c\u901a\u8baf\u4f5c\u8005\u3001\u90a6\u8000\u751f\u7269<\/b>CAR-T\u7814\u53d1\u8d1f\u8d23\u4eba\u675c\u51b0\u6559\u6388\u89e3\u91ca\u9053\u3002<\/b><\/p>\n

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1\u3001\u6781\u5927\u7684\u60a3\u8005\u53ef\u53ca\u6027<\/b><\/p>\n

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2\u3001\u66f4\u9ad8\u7684\u4e34\u5e8a\u5b89\u5168\u6027<\/b><\/p>\n

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3\u3001\u66f4\u4f18\u7684\u4e34\u5e8a\u6cbb\u7597\u6548\u679c<\/b><\/p>\n

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