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\n

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\u4e2d\u56fd\u533b\u5b66\u79d1\u5b66\u9662\u8840\u6db2\u5b66\u7814\u7a76\u6240\u8840\u6db2\u75c5\u533b\u9662\u738b\u5efa\u7965\u6559\u6388\u8868\u793a\uff1a"\u8fd1\u5e74\u6765\uff0c\u8840\u6db2\u80bf\u7624\u9886\u57df\u6d8c\u73b0\u51fa\u8bb8\u591a\u9488\u5bf9\u4e0d\u540c\u9776\u70b9\u7684\u65b0\u836f\uff0c\u4e0d\u540c\u836f\u7269\u4e4b\u95f4\u7684\u8054\u5408\u4f7f\u7528\uff0c\u4f7f\u8840\u6db2\u80bf\u7624\u7684\u6cbb\u7597\u624b\u6bb5\u66f4\u52a0\u4e30\u5bcc\uff0c\u673a\u5236\u4e92\u8865\uff0c\u7597\u6548\u6539\u5584\u663e\u8457\u3002\u8fd9\u4e9b\u521b\u65b0\u836f\u7269\u4e0d\u4ec5\u4e3a\u533b\u751f\u63d0\u4f9b\u4e86\u591a\u6837\u5316\u7684\u6cbb\u7597\u9009\u62e9\uff0c\u8ba9\u4e34\u5e8a\u533b\u751f\u62e5\u6709\u4e86\u66f4\u591a\u6709\u529b\u7684\u2018\u6b66\u5668’\uff0c\u4e5f\u4e3a\u60a3\u8005\u5e26\u6765\u4e86\u65b0\u7684\u751f\u5b58\u5e0c\u671b\u3002\u671f\u5f85\u672a\u6765\u6211\u56fd\u5728\u5dee\u5f02\u5316\u521b\u65b0\u836f\u7269\u7814\u53d1\u65b9\u9762\u80fd\u591f\u6301\u7eed\u53d6\u5f97\u7a81\u7834\uff0c\u8ba9\u66f4\u591a\u60a3\u8005\u6709\u673a\u4f1a\u83b7\u5f97\u66f4\u597d\u7684\u4e34\u5e8a\u83b7\u76ca\u3002"<\/p>\n

\u5317\u4eac\u5927\u5b66\u80bf\u7624\u533b\u9662\u6731\u519b\u6559\u6388<\/b>\u8868\u793a\uff1a"\u5728\u6dcb\u5df4\u7624\u7684\u9776\u5411\u6cbb\u7597\u65b9\u9762\uff0cBTK\u6291\u5236\u5242\u5df2\u7ecf\u5e26\u6765\u4e86\u5f88\u597d\u7684\u6cbb\u7597\u6548\u679c\u3002\u4f46\u5728\u957f\u671f\u6cbb\u7597\u4e2d\u4f9d\u7136\u4f1a\u51fa\u73b0\u590d\u53d1\u3001\u96be\u6cbb\u6216\u8005\u4ea7\u751f\u8010\u836f\u7684\u95ee\u9898\u3002\u800cBCL-2\u6291\u5236\u5242\u3001BTK\u86cb\u767d\u964d\u89e3\u6280\u672f\u7684\u51fa\u73b0\uff0c\u6709\u671b\u89e3\u51b3\u73b0\u6709\u6cbb\u7597\u4e2d\u5b58\u5728\u7684\u96be\u9898\uff0c\u4e3a\u60a3\u8005\u5b9e\u73b0\u66f4\u597d\u7684\u6cbb\u7597\u6548\u679c\u3002\u5e0c\u671b\u6709\u66f4\u591a\u521b\u65b0\u836f\u4f01\u4e1a\uff0c\u6301\u7eed\u7814\u53d1\u51fa\u9ad8\u54c1\u8d28\u7684\u521b\u65b0\u836f\u7269\uff0c\u5171\u540c\u89e3\u51b3\u4e34\u5e8a\u8bca\u7597\u7684\u96be\u70b9\uff0c\u8ba9\u66f4\u591a\u8840\u6db2\u80bf\u7624\u60a3\u8005\u4ece\u521b\u65b0\u6cbb\u7597\u65b9\u6848\u4e2d\u83b7\u76ca\u3002"<\/p>\n

\u767e\u6d4e\u795e\u5dde\u9ad8\u7ea7\u526f\u603b\u88c1\u3001\u5927\u4e2d\u534e\u533a\u533b\u5b66\u4e8b\u52a1\u90e8\u8d1f\u8d23\u4eba\u94b1\u6d2a\u5b87\u5973\u58eb<\/b>\u4ecb\u7ecd\u9053\uff1a"\u8840\u6db2\u80bf\u7624\u4e00\u76f4\u4ee5\u6765\u90fd\u662f\u767e\u6d4e\u795e\u5dde\u91cd\u70b9\u53d1\u529b\u7684\u6838\u5fc3\u9886\u57df\uff0c\u2018\u5934\u5bf9\u5934’ALPINE\u7814\u7a76\u7684\u5ef6\u957f\u968f\u8bbf\u6570\u636e\u518d\u6b21\u9a8c\u8bc1\u4e86\u6cfd\u5e03\u66ff\u5c3c\u4e3a\u2018\u540c\u7c7b\u6700\u4f73’\u6f5c\u529b\u7684BTK\u6291\u5236\u5242\uff1b\u4e0d\u4ec5\u5982\u6b64\uff0c\u767e\u6d4e\u795e\u5dde\u81ea\u7814\u7684BCL-2\u6291\u5236\u5242sonrotoclax\u548cBTK CDAC\u4e5f\u5728\u7814\u7a76\u4e2d\u5c55\u73b0\u51fa\u4e86\u79ef\u6781\u7684\u4e34\u5e8a\u6570\u636e\uff0c\u8fd9\u4e9b\u6570\u636e\u7ed3\u679c\u8fdb\u4e00\u6b65\u8868\u660e\u767e\u6d4e\u795e\u5dde\u529b\u6c42\u4e3a\u8840\u6db2\u80bf\u7624\u60a3\u8005\u5e26\u6765\u9ad8\u54c1\u8d28\u521b\u65b0\u65b9\u6848\u7684\u4fe1\u5fc3\u548c\u51b3\u5fc3\u3002\u6211\u4eec\u5e0c\u671b\u4e0e\u4e13\u5bb6\u4eec\u643a\u624b\u5f00\u5c55\u66f4\u591a\u79d1\u7814\u63a2\u7d22\uff0c\u4e3a\u60a3\u8005\u5e26\u6765\u66f4\u591a\u80fd\u591f\u6297\u51fb\u764c\u75c7\u7684\u521b\u65b0\u836f\u7269\uff0c\u89e3\u9501\u8840\u6db2\u80bf\u7624\u8bca\u7597\u4e2d\u66f4\u591a\u7684\u53ef\u80fd\u6027\u3002"<\/p>\n

\u767e\u6d4e\u795e\u5dde\u81f4\u529b\u4e8e\u52a0\u5f3a\u8840\u6db2\u5b66\u4ea7\u54c1\u7ba1\u7ebf\u5e03\u5c40\uff0c\u6253\u9020\u6ee1\u8db3\u4e34\u5e8a\u9700\u6c42\u7684\u8840\u6db2\u80bf\u7624\u4ea7\u54c1\u7ec4\u5408\u3002\u51ed\u501f\u6cfd\u5e03\u66ff\u5c3c\u4ee4\u4eba\u9f13\u821e\u7684\u7814\u7a76\u6570\u636e\uff0c\u516c\u53f8\u5c55\u73b0\u4e86\u5728\u8840\u6db2\u5b66\u9886\u57df\u7684\u7814\u53d1\u4f18\u52bf\uff0c\u5e76\u57fa\u4e8e\u6cfd\u5e03\u66ff\u5c3c\u7684\u72ec\u7279\u4e34\u5e8a\u7279\u5f81\u4e0d\u65ad\u52a0\u5927\u5bf9\u591a\u79cdB\u7ec6\u80de\u6076\u6027\u80bf\u7624\u7684\u7814\u7a76\u3002\u767e\u6d4e\u795e\u5dde\u7684\u5dee\u5f02\u5316\u5728\u7814BCL-2\u6291\u5236\u5242sonrotoclax\u65e0\u8bba\u4f5c\u4e3a\u5355\u836f\u8fd8\u662f\u4e0e\u5176\u4ed6\u836f\u7269\u8054\u7528\u90fd\u6781\u5177\u524d\u666f\uff0c\u540c\u65f6BTK CDAC\u4e5f\u6709\u671b\u89e3\u51b3\u8840\u6db2\u764c\u75c7\u60a3\u8005\u672a\u88ab\u6ee1\u8db3\u7684\u6cbb\u7597\u9700\u6c42\u3002<\/p>\n

\u5434\u6653\u6ee8\u535a\u58eb\u8868\u793a\uff1a"\u767e\u6d4e\u795e\u5dde\u81f4\u529b\u4e8e\u8ba9\u521b\u65b0\u836f\u7269\u60e0\u53ca\u5168\u7403\u66f4\u591a\u60a3\u8005\uff0c\u5e76\u79ef\u6781\u652f\u6301\u7814\u7a76\u8005\u5f00\u5c55\u533b\u5b66\u7814\u7a76\u63a2\u7d22\uff0c\u52a0\u901f\u6210\u679c\u8f6c\u5316\u4e0e\u4e34\u5e8a\u5e94\u7528\u3002\u6211\u4eec\u5c06\u7ee7\u7eed\u4e0e\u4e34\u5e8a\u4e13\u5bb6\u643a\u624b\uff0c\u805a\u7126\u6539\u5584\u4e34\u5e8a\u6cbb\u7597\u70ed\u70b9\u95ee\u9898\u3001\u63a8\u52a8\u89c4\u8303\u5316\u8bca\u7597\u4e0b\u6c89\uff0c\u4e0d\u65ad\u6539\u5584\u521b\u65b0\u836f\u7269\u7684\u53ef\u53ca\u548c\u53ef\u8d1f\u62c5\u6027\uff0c\u63a8\u52a8\u521b\u65b0\u6210\u679c\u9020\u798f\u66f4\u591a\u60a3\u8005\u53ca\u5bb6\u5ead\u3002"<\/p>\n

\n\n\n\n
\n

[1] CA CANCER J CLIN 2016;66;115-132<\/span><\/p>\n

[2] \u6765\u6e90\uff1aHorner MJ et al., SEER Cancer Statistics Review, Kantar Health Patient Metrics, 2010<\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table><\/div>\n

\u58f0\u660e\uff1a\u672c\u6587\u7ae0\u76ee\u7684\u5728\u4e8e\u4f20\u9012\u533b\u836f\u9886\u57df\u524d\u6cbf\u4fe1\u606f\u548c\u5b66\u672f\u8fdb\u5c55\uff0c\u975e\u5e7f\u544a\u7528\u9014\uff0c\u4e0d\u6784\u6210\u5bf9\u4efb\u4f55\u836f\u7269\u7684\u5546\u4e1a\u63a8\u5e7f\u6216\u5bf9\u8bca\u7597\u65b9\u6848\u7684\u63a8\u8350\u3002\u672c\u6587\u7ae0\u4e2d\u6d89\u53ca\u7684\u4fe1\u606f\u4ec5\u4f9b\u53c2\u8003\uff0c\u4e0e\u75be\u75c5\u6cbb\u7597\u6709\u5173\u4fe1\u606f\u8bf7\u9075\u4ece\u533b\u751f\u6216\u5176\u4ed6\u533b\u7597\u536b\u751f\u4e13\u4e1a\u4eba\u58eb\u7684\u610f\u89c1\u6216\u6307\u5bfc\u3002\u672a\u7ecf\u5141\u8bb8\uff0c\u4e0d\u5f97\u8f6c\u8f7d\u3002<\/i><\/p>\n

<\/div>\n","protected":false},"excerpt":{"rendered":"

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\u767e\u6d4e\u795e\u5dde\u81f4\u529b\u4e8e\u52a0\u5f3a\u8840\u6db2\u5b66\u4ea7\u54c1\u7ba1\u7ebf\u5e03\u5c40\uff0c\u6253\u9020\u6ee1\u8db3\u4e34\u5e8a\u9700\u6c42\u7684\u8840\u6db2\u80bf\u7624\u4ea7\u54c1\u7ec4\u5408\u3002\u51ed\u501f\u6cfd\u5e03\u66ff\u5c3c\u4ee4\u4eba\u9f13\u821e\u7684\u7814\u7a76\u6570\u636e\uff0c\u516c\u53f8\u5c55\u73b0\u4e86\u5728\u8840\u6db2\u5b66\u9886\u57df\u7684\u7814\u53d1\u4f18\u52bf\uff0c\u5e76\u57fa\u4e8e\u6cfd\u5e03\u66ff\u5c3c\u7684\u72ec\u7279\u4e34\u5e8a\u7279\u5f81\u4e0d\u65ad\u52a0\u5927\u5bf9\u591a\u79cdB\u7ec6\u80de\u6076\u6027\u80bf\u7624\u7684\u7814\u7a76\u3002\u767e\u6d4e\u795e\u5dde\u7684\u5dee\u5f02\u5316\u5728\u7814BCL-2\u6291\u5236\u5242sonrotoclax\u65e0\u8bba\u4f5c\u4e3a\u5355\u836f\u8fd8\u662f\u4e0e\u5176\u4ed6\u836f\u7269\u8054\u7528\u90fd\u6781\u5177\u524d\u666f\uff0c\u540c\u65f6BTK CDAC\u4e5f\u6709\u671b\u89e3\u51b3\u8840\u6db2\u764c\u75c7\u60a3\u8005\u672a\u88ab\u6ee1\u8db3\u7684\u6cbb\u7597\u9700\u6c42\u3002 \u5434\u6653\u6ee8\u535a\u58eb\u8868\u793a\uff1a"\u767e\u6d4e\u795e\u5dde\u81f4\u529b\u4e8e\u8ba9\u521b\u65b0\u836f\u7269\u60e0\u53ca\u5168\u7403\u66f4\u591a\u60a3\u8005\uff0c\u5e76\u79ef\u6781\u652f\u6301\u7814\u7a76\u8005\u5f00\u5c55\u533b\u5b66\u7814\u7a76\u63a2\u7d22\uff0c\u52a0\u901f\u6210\u679c\u8f6c\u5316\u4e0e\u4e34\u5e8a\u5e94\u7528\u3002\u6211\u4eec\u5c06\u7ee7\u7eed\u4e0e\u4e34\u5e8a\u4e13\u5bb6\u643a\u624b\uff0c\u805a\u7126\u6539\u5584\u4e34\u5e8a\u6cbb\u7597\u70ed\u70b9\u95ee\u9898\u3001\u63a8\u52a8\u89c4\u8303\u5316\u8bca\u7597\u4e0b\u6c89\uff0c\u4e0d\u65ad\u6539\u5584\u521b\u65b0\u836f\u7269\u7684\u53ef\u53ca\u548c\u53ef\u8d1f\u62c5\u6027\uff0c\u63a8\u52a8\u521b\u65b0\u6210\u679c\u9020\u798f\u66f4\u591a\u60a3\u8005\u53ca\u5bb6\u5ead\u3002" [1] CA CANCER J CLIN 2016;66;115-132 [2] \u6765\u6e90\uff1aHorner MJ et al., SEER Cancer Statistics Review, Kantar Health Patient Metrics, 2010 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