{"id":114284,"date":"2024-07-11T15:38:00","date_gmt":"2024-07-11T08:38:00","guid":{"rendered":"https:\/\/www.xinwengao.com\/cn\/pr\/20240711153800114284"},"modified":"2024-07-12T04:17:03","modified_gmt":"2024-07-11T20:17:03","slug":"%e4%bb%91%e5%8d%a1%e5%a5%88%e5%8d%95%e6%8a%97%e5%9c%a8%e4%b8%ad%e5%9b%bd%e9%a6%99%e6%b8%af%e8%8e%b7%e6%89%b9%e4%b8%8a%e5%b8%82","status":"publish","type":"post","link":"https:\/\/www.xinwengao.com\/cn\/pr\/20240711153800114284","title":{"rendered":"\u4ed1\u5361\u5948\u5355\u6297\u5728\u4e2d\u56fd\u9999\u6e2f\u83b7\u6279\u4e0a\u5e02"},"content":{"rendered":"

\u4e1c\u4eac<\/span>2024\u5e747\u670811\u65e5<\/span> \/\u7f8e\u901a\u793e\/ — \u536b\u6750\u548c\u6e24\u5065\u5ba3\u5e03\uff0c\u4e2d\u56fd\u9999\u6e2f\u7279\u522b\u884c\u653f\u533a\u653f\u5e9c\u536b\u751f\u7f72\u5df2\u6279\u51c6\u4eba\u6e90\u5316\u6297\u53ef\u6eb6\u6027\u805a\u96c6\u6dc0\u7c89\u6837\u86cb\u767d-\u03b2\uff08A\u03b2\uff09\u5355\u514b\u9686\u6297\u4f53\u4ed1\u5361\u5948\u5355\u6297\uff08\u9999\u6e2f\u5546\u54c1\u540d\uff1a\u4e50\u610f\u4fdd®\uff09\u7528\u4e8e\u6cbb\u7597\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u3002\u4ed1\u5361\u5948\u5355\u6297\u7684\u6cbb\u7597\u9002\u7528\u4e8e\u8f7b\u5ea6\u8ba4\u77e5\u969c\u788d\u6216\u8f7b\u5ea6\u75f4\u5446\u9636\u6bb5\u7684\u60a3\u8005\uff0c\u5373\uff1a\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u5f00\u59cb\u6cbb\u7597\u7684\u4eba\u7fa4\u3002<\/p>\n

\u4ed1\u5361\u5948\u5355\u6297\u53ef\u4ee5\u9009\u62e9\u6027\u7ed3\u5408\u53ef\u6eb6\u6027A\u03b2\u805a\u96c6\u4f53\uff08\u539f\u7ea4\u7ef4*\uff09\uff0c\u4ee5\u53caAD\u4e2dA\u03b2\u6591\u5757\u7684\u4e3b\u8981\u6210\u5206\u2014\u2014\u4e0d\u6eb6\u6027A\u03b2\u805a\u96c6\u4f53\uff08\u7ea4\u7ef4\uff09\uff0c\u4ece\u800c\u51cf\u5c11\u5927\u8111\u4e2d\u7684A\u03b2\u539f\u7ea4\u7ef4\u548cA\u03b2\u6591\u5757\u3002\u4ed1\u5361\u5948\u5355\u6297\u662f\u9996\u4e2a\u88ab\u5b8c\u5168\u6279\u51c6\u7684\u901a\u8fc7\u8be5\u673a\u5236\u964d\u4f4e\u75be\u75c5\u8fdb\u5c55\u901f\u5ea6\u5e76\u51cf\u7f13\u8ba4\u77e5\u548c\u5927\u8111\u529f\u80fd\u8870\u9000\u7684\u6cbb\u7597\u65b9\u6cd5\u3002\u4e2d\u56fd\u9999\u6e2f\u662f\u7ee7\u7f8e\u56fd\u3001\u65e5\u672c\u3001\u4e2d\u56fd\u3001\u97e9\u56fd\u4e4b\u540e\uff0c\u7b2c\u4e94\u4e2a\u6279\u51c6\u8be5\u836f\u54c1\u7684\u56fd\u5bb6\u548c\u5730\u533a\u3002<\/p>\n

\u4ed1\u5361\u5948\u5355\u6297\u5728\u4e2d\u56fd\u9999\u6e2f\u83b7\u6279\uff0c\u662f\u57fa\u4e8e\u5168\u7403\u5927\u578bIII\u671f\u7814\u7a76Clarity AD\u3002\u5728Clarity AD\u7814\u7a76\u4e2d\uff0c\u4ed1\u5361\u5948\u5355\u6297\u8fbe\u5230\u4e86\u4e3b\u8981\u7ec8\u70b9\u548c\u6240\u6709\u5173\u952e\u6b21\u8981\u7ec8\u70b9\uff0c\u4e14\u7ed3\u679c\u5177\u6709\u7edf\u8ba1\u5b66\u610f\u4e491\uff0c2<\/sup>\u3002\u5728\u4e2d\u56fd\u9999\u6e2f\uff0c70\u5c81\u53ca\u4ee5\u4e0a\u4eba\u7fa4\u4e2d\u6709 9.3% \u60a3\u6709\u75f4\u5446\u75c7\uff0c85\u5c81\u53ca\u4ee5\u4e0a\u4eba\u7fa4\u4e2d\u7684\u8fd9\u4e00\u6bd4\u4f8b\u589e\u81f3 32%\uff0c\u5176\u4e2d 73.5% \u636e\u62a5\u544a\u60a3\u6709\u963f\u5c14\u8328\u6d77\u9ed8\u75c53\uff0c4<\/sup>\u3002<\/p>\n

\u4ed1\u5361\u5948\u5355\u6297\u7684\u5168\u7403\u5f00\u53d1\u548c\u6ce8\u518c\u7533\u8bf7\u7531\u536b\u6750\u4e3b\u5bfc\uff0c\u800c\u4ea7\u54c1\u5219\u7531\u536b\u6750\u548c\u6e24\u5065\u5171\u540c\u5546\u4e1a\u5316\u548c\u63a8\u5e7f\u3002\u5176\u4e2d\uff0c\u536b\u6750\u62e5\u6709\u6700\u7ec8\u51b3\u7b56\u6743\u3002\u536b\u6750\u5c06\u8d1f\u8d23\u8be5\u4ea7\u54c1\u5728\u4e2d\u56fd\u9999\u6e2f\u7684\u5546\u4e1a\u63a8\u5e7f\u3002<\/p>\n

*\u539f\u7ea4\u7ef4\u88ab\u8ba4\u662f\u5bfc\u81f4AD\u60a3\u8005\u7684\u8111\u635f\u4f24\u7684\u5143\u51f6\uff0c\u5176\u6240\u542b\u6bd2\u6027\u662fA\u03b2\u4e2d\u6700\u5927\u7684\uff0c\u5728\u4e0e\u8fd9\u79cd\u8fdb\u884c\u6027\u8870\u5f31\u7684\u75be\u75c5\u76f8\u5173\u7684\u8ba4\u77e5\u8870\u9000\u4e2d\u8d77\u4e3b\u8981\u4f5c\u75285<\/sup>\u3002\u539f\u7ea4\u7ef4\u5bf9\u5927\u8111\u795e\u7ecf\u5143\u9020\u6210\u635f\u4f24\uff0c\u8fdb\u800c\u901a\u8fc7\u591a\u79cd\u673a\u5236\u5bf9\u8ba4\u77e5\u529f\u80fd\u4ea7\u751f\u8d1f\u9762\u5f71\u54cd\uff0c\u4e0d\u4ec5\u589e\u52a0\u4e86\u4e0d\u6eb6\u6027\u03b2\u6591\u5757\u7684\u5f62\u6210\uff0c\u800c\u4e14\u589e\u52a0\u4e86\u5bf9\u8111\u7ec6\u80de\u819c\u548c\u795e\u7ecf\u7ec6\u80de\u4e4b\u95f4\u6216\u795e\u7ecf\u7ec6\u80de\u4e0e\u5176\u4ed6\u7ec6\u80de\u4e4b\u95f4\u4f20\u9012\u4fe1\u53f7\u7684\u8fde\u63a5\u7684\u76f4\u63a5\u635f\u4f24\u3002\u51cf\u5c11\u539f\u7ea4\u7ef4\u53ef\u51cf\u5c11\u5bf9\u5927\u8111\u795e\u7ecf\u5143\u7684\u635f\u4f24\u548c\u8ba4\u77e5\u529f\u80fd\u969c\u788d\u6765\u963b\u6b62\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u7684\u8fdb\u5c556<\/sup>\u3002<\/p>\n

\n\n\n\n\n\n\n\n\n\n
\n

References<\/b><\/span><\/p>\n<\/td>\n<\/tr>\n

\n

1.<\/sup><\/span>     Eisai presents full results of lecanemab Phase 3 confirmatory Clarity AD study for early Alzheimer’s disease at Clinical Trials on Alzheimer’s Disease (CTAD) conference. Available at: https:\/\/www.eisai.co.jp\/news\/2022\/news202285.html<\/p>\n<\/td>\n<\/tr>\n

\n

2.<\/sup><\/span>     van Dyck, H., et al. Lecanemab in Early Alzheimer’s Disease. New England Journal of Medicine. 2023;388:9-21. https:\/\/www.nejm.org\/doi\/full\/10.1056\/NEJMoa2212948.<\/p>\n<\/td>\n<\/tr>\n

\n

3.<\/sup><\/span>     Department of Health – Press Release "Dementia Care Seminar cum Kick-off Ceremony for Dementia Care Campaign. Available at: https:\/\/www.dh.gov.hk\/english\/press\/2006\/061013.html<\/p>\n<\/td>\n<\/tr>\n

\n

4.<\/sup><\/span>     Ruby Yu , et al. Trends in Prevalence and Mortality of Dementia inElderly Hong Kong Population: Projections, Disease Burden, andImplications for Long-Term Care. Int J Alzheimer’s Dis. 2012(7593):406852. doi: 10.1155\/2012\/406852<\/p>\n<\/td>\n<\/tr>\n

\n

5.<\/sup><\/span>     Amin L, Harris DA. A\u03b2 receptors specifically recognize molecular features displayed by fibril ends and neurotoxic oligomers. Nat Commun. 2021;12:3451. doi:10.1038\/s41467-021-23507-z<\/p>\n<\/td>\n<\/tr>\n

\n

6.<\/sup><\/span>     Ono K, Tsuji M. Protofibrils of Amyloid-\u03b2 are Important Targets of a Disease-Modifying Approach for Alzheimer’s Disease. Int J Mol Sci. 2020;21(3):952. doi: 10.3390\/ijms21030952. PMID: 32023927; PMCID: PMC7037706.<\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table><\/div>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

\u4e1c\u4eac2024\u5e747\u670811\u65e5 \/\u7f8e\u901a\u793e\/ — \u536b\u6750\u548c\u6e24\u5065\u5ba3\u5e03\uff0c\u4e2d\u56fd\u9999\u6e2f\u7279\u522b\u884c\u653f\u533a\u653f\u5e9c\u536b\u751f\u7f72\u5df2\u6279\u51c6\u4eba\u6e90\u5316\u6297\u53ef\u6eb6\u6027\u805a\u96c6\u6dc0\u7c89\u6837\u86cb\u767d-\u03b2\uff08A\u03b2\uff09\u5355\u514b\u9686\u6297\u4f53\u4ed1\u5361\u5948\u5355\u6297\uff08\u9999\u6e2f\u5546\u54c1\u540d\uff1a\u4e50\u610f\u4fdd®\uff09\u7528\u4e8e\u6cbb\u7597\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u3002\u4ed1\u5361\u5948\u5355\u6297\u7684\u6cbb\u7597\u9002\u7528\u4e8e\u8f7b\u5ea6\u8ba4\u77e5\u969c\u788d\u6216\u8f7b\u5ea6\u75f4\u5446\u9636\u6bb5\u7684\u60a3\u8005\uff0c\u5373\uff1a\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u5f00\u59cb\u6cbb\u7597\u7684\u4eba\u7fa4\u3002 \u4ed1\u5361\u5948\u5355\u6297\u53ef\u4ee5\u9009\u62e9\u6027\u7ed3\u5408\u53ef\u6eb6\u6027A\u03b2\u805a\u96c6\u4f53\uff08\u539f\u7ea4\u7ef4*\uff09\uff0c\u4ee5\u53caAD\u4e2dA\u03b2\u6591\u5757\u7684\u4e3b\u8981\u6210\u5206\u2014\u2014\u4e0d\u6eb6\u6027A\u03b2\u805a\u96c6\u4f53\uff08\u7ea4\u7ef4\uff09\uff0c\u4ece\u800c\u51cf\u5c11\u5927\u8111\u4e2d\u7684A\u03b2\u539f\u7ea4\u7ef4\u548cA\u03b2\u6591\u5757\u3002\u4ed1\u5361\u5948\u5355\u6297\u662f\u9996\u4e2a\u88ab\u5b8c\u5168\u6279\u51c6\u7684\u901a\u8fc7\u8be5\u673a\u5236\u964d\u4f4e\u75be\u75c5\u8fdb\u5c55\u901f\u5ea6\u5e76\u51cf\u7f13\u8ba4\u77e5\u548c\u5927\u8111\u529f\u80fd\u8870\u9000\u7684\u6cbb\u7597\u65b9\u6cd5\u3002\u4e2d\u56fd\u9999\u6e2f\u662f\u7ee7\u7f8e\u56fd\u3001\u65e5\u672c\u3001\u4e2d\u56fd\u3001\u97e9\u56fd\u4e4b\u540e\uff0c\u7b2c\u4e94\u4e2a\u6279\u51c6\u8be5\u836f\u54c1\u7684\u56fd\u5bb6\u548c\u5730\u533a\u3002 \u4ed1\u5361\u5948\u5355\u6297\u5728\u4e2d\u56fd\u9999\u6e2f\u83b7\u6279\uff0c\u662f\u57fa\u4e8e\u5168\u7403\u5927\u578bIII\u671f\u7814\u7a76Clarity AD\u3002\u5728Clarity AD\u7814\u7a76\u4e2d\uff0c\u4ed1\u5361\u5948\u5355\u6297\u8fbe\u5230\u4e86\u4e3b\u8981\u7ec8\u70b9\u548c\u6240\u6709\u5173\u952e\u6b21\u8981\u7ec8\u70b9\uff0c\u4e14\u7ed3\u679c\u5177\u6709\u7edf\u8ba1\u5b66\u610f\u4e491\uff0c2\u3002\u5728\u4e2d\u56fd\u9999\u6e2f\uff0c70\u5c81\u53ca\u4ee5\u4e0a\u4eba\u7fa4\u4e2d\u6709 9.3% \u60a3\u6709\u75f4\u5446\u75c7\uff0c85\u5c81\u53ca\u4ee5\u4e0a\u4eba\u7fa4\u4e2d\u7684\u8fd9\u4e00\u6bd4\u4f8b\u589e\u81f3 32%\uff0c\u5176\u4e2d 73.5% \u636e\u62a5\u544a\u60a3\u6709\u963f\u5c14\u8328\u6d77\u9ed8\u75c53\uff0c4\u3002 \u4ed1\u5361\u5948\u5355\u6297\u7684\u5168\u7403\u5f00\u53d1\u548c\u6ce8\u518c\u7533\u8bf7\u7531\u536b\u6750\u4e3b\u5bfc\uff0c\u800c\u4ea7\u54c1\u5219\u7531\u536b\u6750\u548c\u6e24\u5065\u5171\u540c\u5546\u4e1a\u5316\u548c\u63a8\u5e7f\u3002\u5176\u4e2d\uff0c\u536b\u6750\u62e5\u6709\u6700\u7ec8\u51b3\u7b56\u6743\u3002\u536b\u6750\u5c06\u8d1f\u8d23\u8be5\u4ea7\u54c1\u5728\u4e2d\u56fd\u9999\u6e2f\u7684\u5546\u4e1a\u63a8\u5e7f\u3002 *\u539f\u7ea4\u7ef4\u88ab\u8ba4\u662f\u5bfc\u81f4AD\u60a3\u8005\u7684\u8111\u635f\u4f24\u7684\u5143\u51f6\uff0c\u5176\u6240\u542b\u6bd2\u6027\u662fA\u03b2\u4e2d\u6700\u5927\u7684\uff0c\u5728\u4e0e\u8fd9\u79cd\u8fdb\u884c\u6027\u8870\u5f31\u7684\u75be\u75c5\u76f8\u5173\u7684\u8ba4\u77e5\u8870\u9000\u4e2d\u8d77\u4e3b\u8981\u4f5c\u75285\u3002\u539f\u7ea4\u7ef4\u5bf9\u5927\u8111\u795e\u7ecf\u5143\u9020\u6210\u635f\u4f24\uff0c\u8fdb\u800c\u901a\u8fc7\u591a\u79cd\u673a\u5236\u5bf9\u8ba4\u77e5\u529f\u80fd\u4ea7\u751f\u8d1f\u9762\u5f71\u54cd\uff0c\u4e0d\u4ec5\u589e\u52a0\u4e86\u4e0d\u6eb6\u6027\u03b2\u6591\u5757\u7684\u5f62\u6210\uff0c\u800c\u4e14\u589e\u52a0\u4e86\u5bf9\u8111\u7ec6\u80de\u819c\u548c\u795e\u7ecf\u7ec6\u80de\u4e4b\u95f4\u6216\u795e\u7ecf\u7ec6\u80de\u4e0e\u5176\u4ed6\u7ec6\u80de\u4e4b\u95f4\u4f20\u9012\u4fe1\u53f7\u7684\u8fde\u63a5\u7684\u76f4\u63a5\u635f\u4f24\u3002\u51cf\u5c11\u539f\u7ea4\u7ef4\u53ef\u51cf\u5c11\u5bf9\u5927\u8111\u795e\u7ecf\u5143\u7684\u635f\u4f24\u548c\u8ba4\u77e5\u529f\u80fd\u969c\u788d\u6765\u963b\u6b62\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u7684\u8fdb\u5c556\u3002 References 1.     Eisai presents full results of lecanemab Phase 3 confirmatory Clarity AD study for early Alzheimer’s disease at Clinical Trials on Alzheimer’s Disease (CTAD) conference. Available at: https:\/\/www.eisai.co.jp\/news\/2022\/news202285.html 2.     van Dyck, H., et al. Lecanemab in Early Alzheimer’s Disease.… Read More<\/a><\/p>\n","protected":false},"author":556,"featured_media":0,"comment_status":"close","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1965],"tags":[],"class_list":["post-114284","post","type-post","status-publish","format-standard","hentry","category-partnerships"],"amp_enabled":true,"_links":{"self":[{"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/posts\/114284","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/users\/556"}],"replies":[{"embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/comments?post=114284"}],"version-history":[{"count":1,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/posts\/114284\/revisions"}],"predecessor-version":[{"id":114285,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/posts\/114284\/revisions\/114285"}],"wp:attachment":[{"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/media?parent=114284"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/categories?post=114284"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/tags?post=114284"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}