{"id":112628,"date":"2024-04-27T17:39:00","date_gmt":"2024-04-27T10:39:00","guid":{"rendered":"https:\/\/www.xinwengao.com\/cn\/pr\/20240427173900112628"},"modified":"2024-04-28T00:25:48","modified_gmt":"2024-04-27T16:25:48","slug":"2024-csco%e6%8c%87%e5%8d%97%e9%87%8d%e7%a3%85%e6%9b%b4%e6%96%b0%ef%bc%81%e8%88%92%e6%b2%83%e5%93%b2%e7%ba%b3%e5%85%a5i%e7%ba%a7%e6%8e%a8%e8%8d%90%e3%80%81%e6%88%88%e5%88%a9%e6%98%94%e6%9b%bf%e5%b0%bc","status":"publish","type":"post","link":"https:\/\/www.xinwengao.com\/cn\/pr\/20240427173900112628","title":{"rendered":"2024 CSCO\u6307\u5357\u91cd\u78c5\u66f4\u65b0\uff01\u8212\u6c83\u54f2\u7eb3\u5165I\u7ea7\u63a8\u8350\u3001\u6208\u5229\u6614\u66ff\u5c3c\u9996\u83b7\u63a8\u8350\uff0c\u7a81\u7834\u80bf\u7624\u96be\u6cbb\u9776\u70b9\u6cbb\u7597\u74f6\u9888"},"content":{"rendered":"<p><p><span class=\"legendSpanClass\">\u4e0a\u6d77<\/span><span class=\"legendSpanClass\">2024\u5e744\u670827\u65e5<\/span> \/\u7f8e\u901a\u793e\/ &#8212; 2024\u5e744\u670826\u65e5-27\u65e5\uff0c\u4e2d\u56fd\u4e34\u5e8a\u80bf\u7624\u5b66\u4f1a\uff08CSCO\uff09\u6307\u5357\u53d1\u5e03\u4f1a\u4e8e\u6d4e\u5357\u9686\u91cd\u53ec\u5f00\u3002\u5728\u672c\u6b21\u5927\u4f1a\u53d1\u5e03\u76842024\u5e74CSCO\u8bca\u7597\u6307\u5357\u4e2d\uff0c\u8fea\u54f2\u533b\u836f\uff08\u80a1\u7968\u4ee3\u7801\uff1a688192.SH\uff09\u81ea\u4e3b\u7814\u53d1\u7684\u4e24\u6b3e\u6e90\u5934\u521b\u65b0\u836f\u2014\u2014\u8212\u6c83\u54f2<sup>&reg;<\/sup>\uff08\u901a\u7528\u540d\uff1a\u8212\u6c83\u66ff\u5c3c\u7247\uff09\u548c\u6208\u5229\u6614\u66ff\u5c3c\u88ab\u53cc\u53cc\u5217\u5165\u6307\u5357\u63a8\u8350\u7528\u836f\u3002&nbsp;<\/p>\n<div class=\"PRN_ImbeddedAssetReference\" id=\"DivAssetPlaceHolder1\">\n<p> <a href=\"https:\/\/mma.prnasia.com\/media2\/2397453\/Photo.html\" target=\"_blank\" rel=\"nofollow noopener\"> <img decoding=\"async\" src=\"https:\/\/www.xinwengao.com\/cn\/wp-content\/uploads\/Photo-39.jpg\" title=\"\" alt=\"\" \/> <\/a> <br \/><span><\/span><\/p>\n<\/p><\/div>\n<ul type=\"disc\">\n<li>\u8212\u6c83\u54f2<sup>&reg;<\/sup>\u83b7<b>\u300a<\/b><b>CSCO<\/b><b>\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u8bca\u7597\u6307\u5357\uff08<\/b><b>2024<\/b><b>\u7248\uff09\u300b<\/b><b>\u2160<\/b><b>\u7ea7\u63a8\u8350<\/b>\uff0c\u662f\u8be5\u6307\u5357\u4e2d\u9488\u5bf9\u7ecf\u6cbb\u8868\u76ae\u751f\u957f\u56e0\u5b50\u53d7\u4f53\uff08EGFR\uff0920\u53f7\u5916\u663e\u5b50\u63d2\u5165\uff08exon20ins\uff09\u7a81\u53d8\u578b\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff08NSCLC\uff09\u7684<b>\u552f\u4e00<\/b><b>I<\/b><b>\u7ea7\u63a8\u8350\u65b9\u6848<\/b>\u3002<\/li>\n<li>\u6208\u5229\u6614\u66ff\u5c3c\u9996\u6b21\u83b7<b>\u300a<\/b><b>CSCO<\/b><b>\u6dcb\u5df4\u7624\u8bca\u7597\u6307\u5357\uff08<\/b><b>2024<\/b><b>\u7248\uff09\u300b<\/b><b>\u2161<\/b><b>\u7ea7\u63a8\u8350<\/b>\uff0c\u7528\u4e8e\u6cbb\u7597\u590d\u53d1\/\u96be\u6cbb\uff08r\/r\uff09\u5916\u5468T\u7ec6\u80de\u6dcb\u5df4\u7624\uff08PTCL\uff09\u60a3\u8005\u3002<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<p><b>\u65a9\u83b7\u6700\u9ad8\u7ea7\u522b\u63a8\u8350\uff0c\u586b\u8865\u4e8c\u5341\u5e74\u4e34\u5e8a\u7a7a\u767d<br \/><\/b>\u8212\u6c83\u54f2<sup>&reg;<\/sup>\u4f5c\u4e3a\u76ee\u524d\u5168\u7403\u552f\u4e00\u83b7\u6279\u4e14\u53ef\u53ca\u7684\u9776\u5411EGFR exon20ins\u7a81\u53d8\u578bNSCLC\u7684\u5c0f\u5206\u5b50TKI\uff0c\u4e8e\u53bb\u5e74\u5728\u4e2d\u56fd\u9996\u53d1\u4e0a\u5e02\uff0c\u586b\u8865\u4e86\u8be5\u9886\u57df\u957f\u8fbe20\u5e74\u7684\u4e34\u5e8a\u7a7a\u767d\u3002\u6b64\u6b21\u4f5c\u4e3a\u8be5\u9886\u57df\u4e8c\/\u540e\u7ebf\u6cbb\u7597\u7eb3\u5165CSCO\u6307\u5357\uff0c\u8868\u660e\u56fd\u5185\u80ba\u764c\u9886\u57df\u6743\u5a01\u4e13\u5bb6\u5bf9\u8212\u6c83\u54f2<sup>&reg;<\/sup>&quot;\u9ad8\u6548\u4f4e\u6bd2&quot;\u4e34\u5e8a\u6cbb\u7597\u4ef7\u503c\u7684\u9ad8\u5ea6\u8ba4\u53ef\u3002<\/p>\n<p>\u672c\u6b21\u63a8\u8350\u662f\u57fa\u4e8e\u8212\u6c83\u54f2<sup>&reg;<\/sup>\u4e2d\u56fd\u6ce8\u518c\u4e34\u5e8a\u7814\u7a76&quot;\u609f\u7a7a6&quot;\uff08WU-KONG6\uff09\uff0c\u8be5\u7814\u7a76\u7ed3\u679c\u66fe\u83b72023\u5e74\u7f8e\u56fd\u4e34\u5e8a\u80bf\u7624\u5b66\u4f1a\uff08ASCO\uff09\u5e74\u4f1a\u53e3\u5934\u62a5\u544a\uff0c\u5e76\u53d1\u8868\u4e8e\u56fd\u9645\u9876\u7ea7\u671f\u520a\u300a\u67f3\u53f6\u5200\u2022\u547c\u5438\u533b\u5b66\u300b\uff08<i>The Lancet Respiratory Medicine<\/i>\uff0cIF: 76.2\uff09<sup>[1]<\/sup>\uff0c\u7814\u7a76\u6210\u679c\u83b7\u56fd\u9645\u5b66\u672f\u754c\u9ad8\u5ea6\u8ba4\u53ef\u3002\u57fa\u4e8e\u8fd9\u9879\u7814\u7a76\u6210\u679c\uff0c\u8212\u6c83\u54f2<sup>&reg;<\/sup>\u901a\u8fc7\u4f18\u5148\u5ba1\u8bc4\u5728\u56fd\u5185\u83b7\u6279\u4e0a\u5e02\uff0c\u6210\u4e3aEGFR exon20ins\u7a81\u53d8\u578bNSCLC\u4e8c\/\u540e\u7ebf\u6cbb\u7597\u7684\u6807\u51c6\u6cbb\u7597\u624b\u6bb5\u3002<\/p>\n<p><b>\u4e0a\u6d77\u5e02\u4e1c\u65b9\u533b\u9662\u80bf\u7624\u79d1\u4e3b\u4efb\u5468\u5f69\u5b58\u6559\u6388\u8868<span id=\"spanHghlta99c\">\u793a<\/span>\uff1a<\/b>&quot;\u672c\u6b21CSCO\u8bca\u7597\u6307\u5357\u66f4\u65b0\uff0c\u8212\u6c83\u66ff\u5c3c\u4f5c\u4e3aEGFR exon20ins\u7a81\u53d8\u578bNSCLC\u4e8c\/\u540e\u7ebf\u6cbb\u7597\u7684\u552f\u4e00I\u7ea7\u63a8\u8350\u88ab\u7eb3\u5165\u300aCSCO\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u8bca\u7597\u6307\u5357\uff082024\u7248\uff09\u300b\uff0c\u4e00\u65b9\u9762\u5f97\u76ca\u4e8e\u5176\u4e8c\/\u540e\u7ebf\u6cbb\u7597\u4f18\u52bf\u660e\u663e\uff0c\u5ba2\u89c2\u7f13\u89e3\u7387\uff08ORR\uff09\u9ad8\u8fbe61%\uff0c\u8fdc\u8d85\u540c\u7c7b\u836f\u7269\uff0c\u4e14\u6574\u4f53\u5b89\u5168\u6027\u826f\u597d\uff0c\u4e0d\u826f\u53cd\u5e94\u53ef\u63a7\u53ef\u7ba1\u7406<sup>[1]<\/sup>\uff0c\u80fd\u591f\u4e3a\u60a3\u8005\u63d0\u4f9b\u66f4\u52a0\u6709\u6548\u7684\u5168\u65b0\u9009\u62e9\uff1b\u53e6\u4e00\u65b9\u9762\u5219\u6765\u81ea\u4e8e\u5176\u9002\u5e94\u8bc1\u660e\u786e\uff0c\u5df2\u4e8e2023\u5e748\u6708\u5728\u4e2d\u56fd\u83b7\u6279\u4e0a\u5e02\uff0c\u6210\u4e3a\u60a3\u8005\u53ef\u53ca\u7684\u6cbb\u7597\u65b9\u6848\u3002\u76f8\u4fe1\u6b64\u6b21\u66f4\u65b0\uff0c\u80fd\u591f\u4e3a\u4e34\u5e8a\u5b9e\u8df5\u4e2d\u66f4\u591aEGFR exon20ins\u7a81\u53d8\u578bNSCLC\u60a3\u8005\u7684\u6cbb\u7597\u63d0\u4f9b\u53c2\u8003\uff0c\u60e0\u53ca\u66f4\u591a\u7684\u60a3\u8005\u3002&quot;<\/p>\n<p>\u76ee\u524d\uff0c\u8212\u6c83\u54f2<sup>&reg;<\/sup>\u662f<b>\u5168\u7403\u552f\u4e00\u5168\u7ebf\u83b7<\/b><b>FDA<\/b><b>\u7a81\u7834\u6027\u7597\u6cd5\u8ba4\u5b9a<\/b>\u7684\u3001\u9776\u5411EGFR exon20ins\u7a81\u53d8\u578bNSCLC\u7684\u6cbb\u7597\u836f\u7269\u30022023\u5e74\u6b27\u6d32\u80bf\u7624\u5185\u79d1\u5b66\u4f1a\uff08ESMO\uff09\u5927\u4f1a\u62a5\u9053\u4e86\u8212\u6c83\u54f2<sup>&reg;<\/sup>\u5355\u836f\u4e00\u7ebf\u6cbb\u7597EGFR exon20ins\u7a81\u53d8\u578bNSCLC\u7684\u7814\u7a76\u6210\u679c\uff0c\u5c55\u73b0\u51fa&quot;\u540c\u7c7b\u6700\u4f73&quot;\u7684\u7597\u6548\u6f5c\u529b\u3002<\/p>\n<p><b>\u5317\u4eac\u534f\u548c\u533b\u9662\u547c\u5438\u4e0e\u5371\u91cd\u75c7\u533b\u5b66\u79d1\u4e3b\u4efb\u738b\u5b5f\u662d\u6559\u6388\u8868<span id=\"spanHghlt83f4\">\u793a<\/span>\uff1a<\/b>&quot;\u5f88\u9ad8\u5174\u770b\u5230\u8212\u6c83\u66ff\u5c3c\u51ed\u501f&quot;\u609f\u7a7a6&quot;\uff08WU-KONG6\uff09\u7814\u7a76\u7ed3\u679c\uff0c\u88ab\u7eb3\u5165\u300aCSCO\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u8bca\u7597\u6307\u5357\uff082024\u7248\uff09\u300b\uff0c\u5e76\u6210\u4e3aEGFR exon20ins\u7a81\u53d8\u578b\u665a\u671fNSCLC\u4e8c\/\u540e\u7ebf\u6cbb\u7597\u7684\u552f\u4e00I\u7ea7\u63a8\u8350\u6cbb\u7597\u65b9\u6848\u3002\u76ee\u524d\uff0c\u8212\u6c83\u66ff\u5c3c\u5df2\u6210\u4e3aEGFR exon20ins\u7a81\u53d8\u578b\u665a\u671fNSCLC\u4e8c\/\u540e\u7ebf\u6cbb\u7597\u6807\u51c6\u6cbb\u7597\u624b\u6bb5\uff0c\u4e5f\u5728\u79ef\u6781\u63a2\u7d22EGFR exon20ins\u7a81\u53d8\u578b\u665a\u671fNSCLC\u4e00\u7ebf\u6cbb\u7597\u3002\u65e9\u671f\u7814\u7a76\u7ed3\u679c\u63d0\u793a\u8212\u6c83\u66ff\u5c3c\u4e00\u7ebf\u6cbb\u7597EGFR exon20ins\u7a81\u53d8\u578bNSCLC\uff0c\u786e\u8ba4\u7684ORR\u9ad8\u8fbe78.6%\uff0c300mg\u7ec4\u4e2d\u4f4d\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff08mPFS\uff09\u4e3a12.4\u4e2a\u6708\uff0c\u4e14\u5b89\u5168\u6027\u826f\u597d<sup>[2]<\/sup>\uff0c\u518d\u6b21\u9a8c\u8bc1\u4e86\u8212\u6c83\u66ff\u5c3c\u662f\u9488\u5bf9EGFR exon20ins\u7a81\u53d8\u578bNSCLC\u6f5c\u5728\u66f4\u4f18\u7684\u6cbb\u7597\u9009\u62e9\u3002\u975e\u5e38\u671f\u5f85\u5176\u5168\u7403\u591a\u4e2d\u5fc3\u2162\u671f\u7814\u7a76&quot;\u609f\u7a7a28&quot;\uff08WU-KONG28\uff09\u7ed3\u679c\u65e9\u65e5\u516c\u5e03\uff0c\u4e3aEGFR exon20ins\u7a81\u53d8\u578bNSCLC\u4e00\u7ebf\u6cbb\u7597\u63d0\u4f9b\u66f4\u591a\u53c2\u8003\u4f9d\u636e\u3002&quot;<\/p>\n<p><b>\u5168\u65b0\u673a\u5236\u6253\u7834\u50f5\u5c40\uff0c\u7a81\u7834<\/b><b>PTCL<\/b><b>\u6cbb\u7597\u74f6\u9888<br \/><\/b>\u6208\u5229\u6614\u66ff\u5c3c\u662f\u5168\u7403<b>\u9996\u4e2a\u4e14\u552f\u4e00<\/b>\u9488\u5bf9PTCL\u7684\u9ad8\u9009\u62e9\u6027JAK1\u6291\u5236\u5242\uff0c\u5f00\u521b\u4e86\u5168\u7403\u9996\u4e2a\u901a\u8fc7\u9776\u5411JAK\/STAT\u901a\u8def\u6cbb\u7597PTCL\u7684<b>\u5168\u65b0\u4f5c\u7528\u673a\u5236<\/b>\u3002\u6b64\u6b21\u88ab\u7eb3\u5165CSCO\u6307\u5357\u63a8\u8350\u662f\u57fa\u4e8e\u4e00\u9879\u5168\u7403\u591a\u4e2d\u5fc3\u6ce8\u518c\u4e34\u5e8a\u7814\u7a76\uff08JACKPOT8 Part B\uff09\uff0c\u6570\u636e\u663e\u793a\u6208\u5229\u6614\u66ff\u5c3c\u5355\u836f\u6cbb\u7597r\/r PTCL\u7684ORR\u4e3a44.3%\uff0c\u5b8c\u5168\u7f13\u89e3\uff08CR\uff09\u7387\u4e3a23.9%\uff0c\u4e2d\u4f4d\u7f13\u89e3\u6301\u7eed\u65f6\u95f4\uff08DoR\uff09\u957f\u8fbe20.7\u4e2a\u6708\uff0c\u5747\u4f18\u4e8e\u73b0\u6709\u7597\u6cd5\u8fd1\u4e24\u500d\u3002\u7814\u7a76\u6210\u679c\u5165\u90092023\u5e74\u7f8e\u56fd\u8840\u6db2\u5b66\u4f1a\uff08ASH\uff09\u5e74\u4f1a\u53e3\u5934\u62a5\u544a\uff0c\u5e76\u540c\u6b65\u53d1\u8868\u4e8e\u300a\u67f3\u53f6\u5200\u2022\u80bf\u7624\u5b66\u300b\uff08<i>Lancet Oncology<\/i>\uff0cIF\uff1a54.4\uff09<sup>[3]<\/sup>\u3002<\/p>\n<p><b>\u5317\u4eac\u5927\u5b66\u80bf\u7624\u533b\u9662\u6731\u519b\u6559\u6388\u8868<span id=\"spanHghlt35de\">\u793a<\/span>\uff1a<\/b>&quot;\u6208\u5229\u6614\u66ff\u5c3c\u5177\u6709\u65b0\u673a\u5236\u3001\u65b0\u7ed3\u6784\uff0c\u662f\u5168\u7403\u9996\u6b3e\u9488\u5bf9PTCL\u7684\u53e3\u670dJAK1\u9ad8\u9009\u62e9\u6027\u6291\u5236\u5242\uff0c\u5177\u6709\u826f\u597d\u7684\u836f\u4ee3\u52a8\u529b\u5b66\u7279\u6027\uff0c\u662f\u552f\u4e00\u5728\u8840\u6db2\u9886\u57df\u6709\u7a81\u7834\u7684JAK\u6291\u5236\u5242\uff0c\u4ece\u673a\u5236\u53ca\u4e34\u5e8a\u7ed3\u679c\u9a8c\u8bc1\u4e86\u5176\u5177\u6709PTCL\u5168\u4e9a\u578b\u83b7\u76ca\u7684\u6f5c\u8d28\u3002\u4e34\u5e8a\u8868\u73b0\u5353\u8d8a\uff1a\u8f83\u9ad8\u4e14\u6301\u7eed\u7684\u5ba2\u89c2\u7f13\u89e3\u7387\uff0c\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\u826f\u597d\uff0c\u6709\u671b\u51b2\u7834PTCL\u6cbb\u7597\u74f6\u9888<sup>[3]<\/sup>\u3002&quot;<\/p>\n<p><b>\u54c8\u5c14\u6ee8\u8840\u6db2\u75c5\u80bf\u7624\u7814\u7a76\u6240\u9a6c\u519b\u6559\u6388\u8868<span id=\"spanHghltfeb3\">\u793a<\/span>\uff1a<\/b>&quot;\u57fa\u4e8e\u6208\u5229\u6614\u66ff\u5c3c\u5728\u4e34\u5e8a\u7814\u7a76\u4e2d\u5c55\u73b0\u51fa\u6765\u7684\u5353\u8d8a\u6570\u636e\uff0c\u4eca\u5e74CSCO\u6dcb\u5df4\u7624\u8bca\u7597\u6307\u5357\u9996\u6b21\u5c06\u6208\u5229\u6614\u66ff\u5c3c\u7eb3\u5165\u6307\u5357\uff0c\u53ef\u5355\u836f\u7528\u4e8e\u6cbb\u7597r\/r PTCL\uff08\u2161\u7ea7\u63a8\u8350\uff09\uff0c\u4e0d\u7ba1\u662f\u5373\u5c06\u83b7\u6279\u7684r\/r PTCL\u5355\u836f\u4f7f\u7528\u8fd8\u662f\u5c06\u6765\u8054\u5408\u5e94\u7528\u7684\u63a2\u7d22\uff0c\u5305\u62ec\u5df2\u7ecf\u516c\u5e03\u7684\u5355\u836f\u7ef4\u6301\u6cbb\u7597\uff0c\u671f\u5f85\u6208\u5229\u6614\u66ff\u5c3c\u5728PTCL\u9886\u57df\u7684\u66f4\u591a\u63a2\u7d22\uff0c\u9020\u798f\u66f4\u591a\u6dcb\u5df4\u7624\u60a3\u8005\u3002&quot;<\/p>\n<p>\u76ee\u524d\uff0c\u6208\u5229\u6614\u66ff\u5c3c\u5df2\u83b7\u7f8e\u56fd\u98df\u54c1\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08FDA\uff09\u6388\u4e88\u7684&quot;\u5feb\u901f\u901a\u9053\u8ba4\u5b9a&quot;\uff08Fast Track Designation\uff09\u3002\u540c\u65f6\uff0c\u5176\u65b0\u836f\u4e0a\u5e02\u7533\u8bf7\u5df2\u88ab\u56fd\u5bb6\u836f\u76d1\u5c40\uff08NMPA\uff09\u53d7\u7406\u5e76\u7eb3\u5165\u4f18\u5148\u5ba1\u8bc4\uff0c\u6709\u671b\u5c3d\u5feb\u4e3a\u56fd\u5185\u60a3\u8005\u5e26\u6765\u6cbb\u7597\u65b0\u9009\u62e9\u3002<\/p>\n<p><b>\u53c2\u8003\u6587\u732e\uff1a<\/b><\/p>\n<div>\n<table border=\"0\" cellspacing=\"0\" cellpadding=\"1\" class=\"prnbcc\">\n<tbody>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\"><sup>[1]<\/sup><\/span>&nbsp;Wang, Mengzhao, et al. The Lancet Respiratory Medicine 12.3 (2024): 217-224.<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\"><sup>[2]<\/sup><\/span> J.C. Yang, M. Wang, Y. Luo, et al. Sunvozertinib as first-line treatment in NSCLC patients with EGFR Exon20 insertion mutations. 2023 ESMO 1325P.<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\"><sup>[3]<\/sup><\/span> Song, Yuqin, et al. The Lancet Oncology (2023).<\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table><\/div>\n<p>&nbsp;<\/p>\n<p>\u5173\u4e8e\u8212\u6c83\u54f2<sup>&reg;<\/sup>\uff08\u8212\u6c83\u66ff\u5c3c\uff09<br \/>\u8212\u6c83\u54f2<sup>&reg;<\/sup>\u662f\u4e00\u6b3e\u53e3\u670d\u3001\u4e0d\u53ef\u9006\u3001\u9488\u5bf9\u591a\u79cdEGFR\u7a81\u53d8\u4e9a\u578b\u7684\u9ad8\u9009\u62e9\u6027EGFR\u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5242\uff08TKI\uff09\uff0c\u9996\u4e2a\u9002\u5e94\u75c7\u4e8e2023\u5e748\u6708\u83b7\u56fd\u5bb6\u836f\u76d1\u5c40\u901a\u8fc7\u4f18\u5148\u5ba1\u8bc4\u5728\u4e2d\u56fd\u6279\u51c6\u4e0a\u5e02\uff0c\u7528\u4e8e\u65e2\u5f80\u7ecf\u542b\u94c2\u5316\u7597\u51fa\u73b0\u75be\u75c5\u8fdb\u5c55\uff0c\u6216\u4e0d\u8010\u53d7\u542b\u94c2\u5316\u7597\uff0c\u5e76\u4e14\u7ecf\u68c0\u6d4b\u786e\u8ba4\u5b58\u5728\u8868\u76ae\u751f\u957f\u56e0\u5b50\u53d7\u4f53\uff08EGFR\uff0920\u53f7\u5916\u663e\u5b50\u63d2\u5165\uff08exon20ins\uff09\u7a81\u53d8\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff08NSCLC\uff09\u60a3\u8005\u3002<\/p>\n<p>\u5173\u4e8e\u6208\u5229\u6614\u66ff\u5c3c<br \/>\u6208\u5229\u6614\u66ff\u5c3c\u662f\u5168\u7403\u9996\u4e2a\u4e14\u552f\u4e00\u9488\u5bf9\u5916\u5468T\u7ec6\u80de\u6dcb\u5df4\u7624\uff08PTCL\uff09\u7684\u9ad8\u9009\u62e9\u6027JAK1\u6291\u5236\u5242\uff0c\u9996\u4e2a\u9002\u5e94\u75c7\u4e3a\u590d\u53d1\/\u96be\u6cbb\u6027\uff08r\/r\uff09PTCL\uff0c\u6b63\u5728\u4e2d\u56fd\u3001\u7f8e\u56fd\u3001\u97e9\u56fd\u548c\u6fb3\u5927\u5229\u4e9a\u7b49\u56fd\u5bb6\u5f00\u5c55\u5173\u952e\u6027\u4e34\u5e8a\u8bd5\u9a8c\u3002\u6208\u5229\u6614\u66ff\u5c3c\u4e8e2022\u5e742\u6708\u83b7\u7f8e\u56fd\u98df\u54c1\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08FDA\uff09&quot;\u5feb\u901f\u901a\u9053\u8ba4\u5b9a&quot;\uff08Fast Track Designation\uff09\u30022023\u5e749\u6708\uff0c\u6208\u5229\u6614\u66ff\u5c3c\u65b0\u836f\u4e0a\u5e02\u7533\u8bf7\u83b7\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08NMPA\uff09\u65b0\u836f\u5ba1\u8bc4\u4e2d\u5fc3\uff08CDE\uff09\u53d7\u7406\u5e76\u7eb3\u5165\u4f18\u5148\u5ba1\u8bc4\u3002<\/p>\n<p>\u5173\u4e8e\u8fea\u54f2\u533b\u836f<br \/>\u8fea\u54f2\u533b\u836f\uff08\u80a1\u7968\u4ee3\u7801\uff1a688192.SH\uff09\u662f\u4e00\u5bb6\u521b\u65b0\u578b\u751f\u7269\u533b\u836f\u4f01\u4e1a\uff0c\u4e13\u6ce8\u4e8e\u6076\u6027\u80bf\u7624\u3001\u514d\u75ab\u6027\u75be\u75c5\u9886\u57df\u521b\u65b0\u7597\u6cd5\u7684\u7814\u7a76\u3001\u5f00\u53d1\u548c\u5546\u4e1a\u5316\u3002\u516c\u53f8\u575a\u6301\u6e90\u5934\u521b\u65b0\u7684\u7814\u53d1\u7406\u5ff5\uff0c\u4ee5\u63a8\u51fa\u5168\u7403\u9996\u521b\u836f\u7269\uff08First-in-class\uff09\u548c\u5177\u6709\u7a81\u7834\u6027\u6f5c\u529b\u7684\u6cbb\u7597\u65b9\u6cd5\u4e3a\u76ee\u6807\uff0c\u65e8\u5728\u586b\u8865\u5168\u7403\u672a\u88ab\u6ee1\u8db3\u7684\u4e34\u5e8a\u9700\u6c42\u3002\u57fa\u4e8e\u884c\u4e1a\u9886\u5148\u7684\u8f6c\u5316\u79d1\u5b66\u548c\u65b0\u836f\u5206\u5b50\u8bbe\u8ba1\u4e0e\u7b5b\u9009\u6280\u672f\u5e73\u53f0\uff0c\u516c\u53f8\u5df2\u5efa\u7acb\u4e86\u5177\u5907\u5168\u7403\u7ade\u4e89\u529b\u7684\u4ea7\u54c1\u7ba1\u7ebf\uff0c\u4e24\u5927\u9886\u5148\u4ea7\u54c1\u5904\u4e8e\u5168\u7403\u5173\u952e\u6027\u4e34\u5e8a\u8bd5\u9a8c\u9636\u6bb5\uff0c\u5176\u4e2d\u4e00\u6b3e\u5df2\u83b7\u6279\u4e0a\u5e02\u3002\u6b32\u4e86\u89e3\u66f4\u591a\u4fe1\u606f\uff0c\u8bf7\u5173\u6ce8\u5fae\u4fe1\u516c\u4f17\u53f7\uff1a\u8fea\u54f2Dizal\uff0c\u6216\u8bbf\u95ee<a href=\"https:\/\/www.dizalpharma.com\/\" target=\"_blank\" rel=\"nofollow noopener\">www.dizalpharma.com<\/a>\u3002<\/p>\n<p>\u524d\u77bb\u6027\u58f0\u660e<br \/>\u672c\u65b0\u95fb\u6240\u53d1\u5e03\u7684\u4fe1\u606f\u4e2d\u53ef\u80fd\u4f1a\u5305\u542b\u67d0\u4e9b\u524d\u77bb\u6027\u8868\u8ff0\u3002\u8fd9\u4e9b\u8868\u8ff0\u672c\u8d28\u4e0a\u5177\u6709\u76f8\u5f53\u98ce\u9669\u548c\u4e0d\u786e\u5b9a\u6027\u3002\u5728\u4f7f\u7528&quot;\u9884\u671f&quot;\u3001&quot;\u76f8\u4fe1&quot;\u3001&quot;\u9884\u6d4b&quot;\u3001&quot;\u671f\u671b&quot;\u3001&quot;\u6253\u7b97&quot;\u3001&quot;\u6709\u671b&quot;\u53ca\u5176\u4ed6\u7c7b\u4f3c\u8bcd\u8bed\u8fdb\u884c\u8868\u8ff0\u65f6\uff0c\u51e1\u4e0e\u672c\u516c\u53f8\u6709\u5173\u7684\uff0c\u76ee\u7684\u5747\u662f\u8981\u6307\u660e\u5176\u5c5e\u524d\u77bb\u6027\u8868\u8ff0\u3002<br \/>\u524d\u77bb\u6027\u8868\u8ff0\u4e43\u57fa\u4e8e\u672c\u516c\u53f8\u7ba1\u7406\u5c42\u5728\u505a\u51fa\u8868\u8ff0\u65f6\u5bf9\u672a\u6765\u4e8b\u52a1\u7684\u73b0\u6709\u770b\u6cd5\u3001\u5047\u8bbe\u3001\u671f\u671b\u3001\u4f30\u8ba1\u3001\u9884\u6d4b\u548c\u7406\u89e3\u3002\u8fd9\u4e9b\u8868\u8ff0\u5e76\u975e\u5bf9\u672a\u6765\u53d1\u5c55\u7684\u4fdd\u8bc1\uff0c\u4f1a\u53d7\u5230\u98ce\u9669\u3001\u4e0d\u786e\u6027\u53ca\u5176\u4ed6\u56e0\u7d20\u7684\u5f71\u54cd\uff0c\u6709\u4e9b\u4e43\u8d85\u51fa\u672c\u516c\u53f8\u7684\u63a7\u5236\u8303\u56f4\uff0c\u96be\u4ee5\u9884\u8ba1\u3002\u56e0\u6b64\uff0c\u53d7\u6211\u4eec\u7684\u4e1a\u52a1\u3001\u7ade\u4e89\u73af\u5883\u3001\u653f\u6cbb\u3001\u7ecf\u6d4e\u3001\u6cd5\u5f8b\u548c\u793e\u4f1a\u60c5\u51b5\u7684\u672a\u6765\u53d8\u5316\u53ca\u53d1\u5c55\u7684\u5f71\u54cd\uff0c\u5b9e\u9645\u7ed3\u679c\u53ef\u80fd\u4f1a\u4e0e\u524d\u77bb\u6027\u8868\u8ff0\u6240\u542b\u8d44\u6599\u6709\u8f83\u5927\u5dee\u522b\u3002<br \/>\u672c\u516c\u53f8\u3001\u672c\u516c\u53f8\u8463\u4e8b\u53ca\u96c7\u5458\u6982\u4e0d\u627f\u62c5\uff08a\uff09\u66f4\u6b63\u6216\u66f4\u65b0\u672c\u7f51\u7ad9\u6240\u8f7d\u524d\u77bb\u6027\u8868\u8ff0\u7684\u4efb\u4f55\u4e49\u52a1\uff1b\u53ca\uff08b\uff09&nbsp;\u82e5\u56e0\u4efb\u4f55\u524d\u77bb\u6027\u8868\u8ff0\u4e0d\u80fd\u5b9e\u73b0\u6216\u53d8\u6210\u4e0d\u6b63\u786e\u800c\u5f15\u81f4\u7684\u4efb\u4f55\u8d23\u4efb\u3002<\/p>\n<p>\u66f4\u591a\u4fe1\u606f\uff0c\u656c\u8bf7\u8054\u7cfb<br \/><a href=\"mailto:\u6295\u8d44\u8005\u5173\u7cfb\uff1air@dizalpharma.com\" rel=\"nofollow\">\u6295\u8d44\u8005\u5173\u7cfb\uff1air@dizalpharma.com<\/a><br \/><a href=\"mailto:\u5546\u52a1\u5408\u4f5c\uff1abd@dizalpharma.com\" rel=\"nofollow\">\u5546\u52a1\u5408\u4f5c\uff1abd@dizalpharma.com<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u4e0a\u6d772024\u5e744\u670827\u65e5 \/\u7f8e\u901a\u793e\/ &#8212; 2024\u5e744\u670826\u65e5-27\u65e5\uff0c\u4e2d\u56fd\u4e34\u5e8a\u80bf\u7624\u5b66\u4f1a\uff08CSCO\uff09\u6307\u5357\u53d1\u5e03\u4f1a\u4e8e\u6d4e\u5357\u9686\u91cd\u53ec\u5f00\u3002\u5728\u672c\u6b21\u5927\u4f1a\u53d1\u5e03\u76842024\u5e74CSCO\u8bca\u7597\u6307\u5357\u4e2d\uff0c\u8fea\u54f2\u533b\u836f\uff08\u80a1\u7968\u4ee3\u7801\uff1a688192.SH\uff09\u81ea\u4e3b\u7814\u53d1\u7684\u4e24\u6b3e\u6e90\u5934\u521b\u65b0\u836f\u2014\u2014\u8212\u6c83\u54f2&reg;\uff08\u901a\u7528\u540d\uff1a\u8212\u6c83\u66ff\u5c3c\u7247\uff09\u548c\u6208\u5229\u6614\u66ff\u5c3c\u88ab\u53cc\u53cc\u5217\u5165\u6307\u5357\u63a8\u8350\u7528\u836f\u3002&nbsp; 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PTCL\u7684ORR\u4e3a44.3%\uff0c\u5b8c\u5168\u7f13\u89e3\uff08CR\uff09\u7387\u4e3a23.9%\uff0c\u4e2d\u4f4d\u7f13\u89e3\u6301\u7eed\u65f6\u95f4\uff08DoR\uff09\u957f\u8fbe20.7\u4e2a\u6708\uff0c\u5747\u4f18\u4e8e\u73b0\u6709\u7597\u6cd5\u8fd1\u4e24\u500d\u3002\u7814\u7a76\u6210\u679c\u5165\u90092023\u5e74\u7f8e\u56fd\u8840\u6db2\u5b66\u4f1a\uff08ASH\uff09\u5e74\u4f1a\u53e3\u5934\u62a5\u544a\uff0c\u5e76\u540c\u6b65\u53d1\u8868\u4e8e\u300a\u67f3\u53f6\u5200\u2022\u80bf\u7624\u5b66\u300b\uff08Lancet Oncology\uff0cIF\uff1a54.4\uff09[3]\u3002 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\u76ee\u524d\uff0c\u6208\u5229\u6614\u66ff\u5c3c\u5df2\u83b7\u7f8e\u56fd\u98df\u54c1\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08FDA\uff09\u6388\u4e88\u7684&quot;\u5feb\u901f\u901a\u9053\u8ba4\u5b9a&quot;\uff08Fast Track Designation\uff09\u3002\u540c\u65f6\uff0c\u5176\u65b0\u836f\u4e0a\u5e02\u7533\u8bf7\u5df2\u88ab\u56fd\u5bb6\u836f\u76d1\u5c40\uff08NMPA\uff09\u53d7\u7406\u5e76\u7eb3\u5165\u4f18\u5148\u5ba1\u8bc4\uff0c\u6709\u671b\u5c3d\u5feb\u4e3a\u56fd\u5185\u60a3\u8005\u5e26\u6765\u6cbb\u7597\u65b0\u9009\u62e9\u3002 \u53c2\u8003\u6587\u732e\uff1a [1]&nbsp;Wang, Mengzhao, et al. The Lancet Respiratory Medicine 12.3 (2024): 217-224. [2] J.C. 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