{"id":112258,"date":"2024-04-25T12:54:00","date_gmt":"2024-04-25T05:54:00","guid":{"rendered":"https:\/\/www.xinwengao.com\/cn\/pr\/20240425125400112258"},"modified":"2024-04-26T00:23:47","modified_gmt":"2024-04-25T16:23:47","slug":"%e6%88%90%e9%83%bd%e5%85%88%e5%af%bc%e6%8a%ab%e9%9c%b2%e4%b8%9a%e7%bb%a9%e6%8a%a5%e5%91%8a%ef%bc%9a%e6%a0%b8%e5%bf%83%e4%b8%9a%e5%8a%a1%e5%9b%9e%e5%8d%87%e5%90%91%e5%a5%bd","status":"publish","type":"post","link":"https:\/\/www.xinwengao.com\/cn\/pr\/20240425125400112258","title":{"rendered":"\u6210\u90fd\u5148\u5bfc\u62ab\u9732\u4e1a\u7ee9\u62a5\u544a\uff1a\u6838\u5fc3\u4e1a\u52a1\u56de\u5347\u5411\u597d"},"content":{"rendered":"\n\n\n
\"\"<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\u521b\u65b0\u80fd\u529b\u77e9\u9635\u6301\u7eed\u91ca\u653e\u589e\u957f\u52bf\u80fd<\/span><\/b><\/p>\n

\u6210\u90fd<\/span>2024\u5e744\u670825\u65e5<\/span> \/\u7f8e\u901a\u793e\/ — 4\u670824\u65e5\u665a\u95f4\uff0c\u4e0a\u6d77\u8bc1\u5238\u4ea4\u6613\u6240\u79d1\u521b\u677f\u4e0a\u5e02\u516c\u53f8\u6210\u90fd\u5148\u5bfc\u836f\u7269\u5f00\u53d1\u80a1\u4efd\u6709\u9650\u516c\u53f8\uff08\u80a1\u7968\u4ee3\u7801\uff1a688222.SH\uff0c\u4ee5\u4e0b\u7b80\u79f0"\u6210\u90fd\u5148\u5bfc"\u6216"\u516c\u53f8"\uff09\u516c\u5e032023\u5e74\u5e74\u5ea6\u62a5\u544a\u53ca2024\u5e74\u7b2c\u4e00\u5b63\u5ea6\u62a5\u544a\uff08\u4ee5\u4e0b\u5206\u522b\u7b80\u79f0"\u5e74\u62a5"\u3001"\u4e00\u5b63\u62a5"\uff09\u3002\u81ea2023\u5e74\u4ee5\u6765\uff0c\u968f\u7740\u56fd\u5185\u5916\u8de8\u5883\u4ea4\u6d41\u9010\u6e10\u6062\u590d\uff0c\u516c\u53f8\u8fdb\u4e00\u6b65\u4f18\u5316\u56fd\u9645\u56fd\u5185\u5e02\u573a\u7b56\u7565\uff0c\u6301\u7eed\u62d3\u5c55\u4e1a\u52a1\u8303\u56f4\u548c\u5408\u4f5c\u4f19\u4f34\uff0c\u4e0d\u65ad\u63a2\u7d22\u65b0\u7684\u5546\u4e1a\u673a\u4f1a\u5e76\u63a8\u8fdb\u843d\u5730\u8f6c\u5316\uff0c\u4e0e\u5168\u7403\u591a\u5bb6\u751f\u7269\u5236\u836f\u516c\u53f8\u548c\u7814\u7a76\u673a\u6784\u8fbe\u6210\u6df1\u5ea6\u5408\u4f5c\uff0c\u5171\u540c\u63a8\u8fdb\u7814\u53d1\u9879\u76ee\u6210\u679c\u5546\u4e1a\u8f6c\u5316\uff0c\u4fdd\u6301\u4e86\u4e3b\u8425\u4e1a\u52a1\u7684\u57fa\u672c\u7a33\u5b9a\u53ca\u53d1\u5c55\u97e7\u6027\u30022023\u5e74\uff0c\u516c\u53f8\u5b9e\u73b0\u8425\u4e1a\u6536\u51653.71\u4ebf\u5143\uff0c\u540c\u6bd4\u589e\u957f12.64%\uff1b\u5b9e\u73b0\u5f52\u6bcd\u51c0\u5229\u6da64,071.85\u4e07\u5143\uff0c\u540c\u6bd4\u589e\u957f61.16%\uff1b\u4e3b\u8425\u4e1a\u52a1\u6574\u4f53\u6bdb\u5229\u738749.28%\uff0c\u540c\u6bd4\u4e0a\u53471.61\u4e2a\u767e\u5206\u70b9\uff1b\u7ecf\u8425\u6027\u73b0\u91d1\u6d41\u51c0\u989d1.25\u4ebf\u5143\uff0c\u540c\u6bd4\u589e\u957f137.42%\uff1b\u516c\u53f8\u62df\u6bcf10\u80a1\u6d3e\u53d1\u73b0\u91d1\u7ea2\u52290.5\u5143\uff08\u542b\u7a0e\uff09\uff0c\u5206\u7ea2\u603b\u989d\u5360\u5e74\u5ea6\u5f52\u6bcd\u51c0\u5229\u6da6\u768449.05%\u3002\u826f\u597d\u7684\u6062\u590d\u589e\u957f\u6001\u52bf\u4ea6\u5ef6\u7eed\u81f32024\u5e74\u521d\uff0c\u4eca\u5e74\u4e00\u5b63\u5ea6\u516c\u53f8\u5b9e\u73b0\u8425\u4e1a\u6536\u51651.07\u4ebf\u5143\uff0c\u540c\u6bd4\u589e\u957f54.35%\uff1b\u5b9e\u73b0\u5f52\u6bcd\u51c0\u5229\u6da61,394.00\u4e07\u5143\uff0c\u6263\u975e\u5f52\u6bcd\u51c0\u5229\u6da6819.42\u4e07\u5143\uff0c\u540c\u6bd4\u5747\u5b9e\u73b0\u7531\u8d1f\u8f6c\u6b63\u3002<\/p>\n

\n<\/p><\/div>\n

\u6210\u90fd\u5148\u5bfc\u8463\u4e8b\u957f\u517c\u9996\u5e2d\u6267\u884c\u5b98\u674e\u8fdb\u535a\u58eb<\/b>\u8868\u793a\uff1a"2023\u5e74\uff0c\u5728\u590d\u6742\u591a\u53d8\u7684\u5916\u90e8\u73af\u5883\u4e0b\uff0c\u6210\u90fd\u5148\u5bfc\u5bf9\u5185\u4e0d\u65ad\u63d0\u9ad8\u521b\u65b0\u80fd\u529b\uff0c\u592f\u5b9e\u6269\u5927\u5dee\u5f02\u5316\u4f18\u52bf\uff0c\u5bf9\u5916\u6df1\u5165\u6d1e\u5bdf\u6301\u7eed\u53d8\u5316\u7684\u5e02\u573a\u9700\u6c42\uff0c\u63d0\u4f9b\u7075\u6d3b\u4e14\u591a\u5143\u5316\u7684\u4ea7\u54c1\u548c\u670d\u52a1\u7ec4\u5408\u3002\u516c\u53f8\u7684\u6062\u590d\u548c\u589e\u957f\u52bf\u80fd\u5f97\u5230\u4e0d\u65ad\u7d2f\u79ef\uff0c\u4e3b\u8425\u4e1a\u52a1\u57282023\u5e74\u56de\u6e29\u660e\u663e\u30022024\u5e74\u4ee5\u6765\uff0c\u9a71\u52a8\u4e1a\u52a1\u53d1\u5c55\u7684\u79ef\u6781\u56e0\u7d20\u4ecd\u5728\u6301\u7eed\u53d1\u6325\u4f5c\u7528\uff0c\u516c\u53f8\u5b9e\u73b0\u826f\u597d\u5f00\u5c40\u3002\u6210\u90fd\u5148\u5bfc\u5c06\u6301\u7eed\u63d0\u9ad8\u7ecf\u8425\u6548\u7387\uff0c\u8fdb\u4e00\u6b65\u5de9\u56fa\u548c\u63d0\u5347\u6838\u5fc3\u7ade\u4e89\u4f18\u52bf\uff0c\u52a0\u5f3a\u5168\u7403\u5546\u52a1\u56e2\u961f\u4e0e\u4e1a\u52a1\u5355\u5143\u7684\u7d27\u5bc6\u534f\u4f5c\uff0c\u63a8\u52a8\u5546\u4e1a\u9879\u76ee\u4f18\u8d28\u9ad8\u6548\u4ea4\u4ed8\uff0c\u5e76\u4e0d\u65ad\u5f00\u62d3\u65b0\u5174\u6280\u672f\u9886\u57df\uff0c\u57f9\u80b2\u66f4\u591a\u9ad8\u8d28\u91cf\u7684\u589e\u957f\u70b9\uff0c\u4e3a\u5ba2\u6237\u3001\u5458\u5de5\u3001\u80a1\u4e1c\u548c\u793e\u4f1a\u521b\u9020\u66f4\u591a\u957f\u671f\u4ef7\u503c\u3002"<\/p>\n

\u6536\u5165\uff1a<\/b>DEL<\/b>\u6838\u5fc3\u4e1a\u52a1\u6062\u590d\u663e\u8457\uff0c\u5176\u4ed6\u6280\u672f\u5e73\u53f0\u548c\u5173\u952e\u65b0\u836f\u7814\u53d1\u80fd\u529b\u663e\u73b0\u589e\u957f\u6f5c\u529b<\/b><\/p>\n

\u6210\u90fd\u5148\u5bfc\u81ea\u6210\u7acb\u4ee5\u6765\u4e00\u76f4\u805a\u7126\u5c0f\u5206\u5b50\u53ca\u6838\u9178\u65b0\u836f\u7814\u53d1\u7684\u53d1\u73b0\u4e0e\u4f18\u5316\uff0c\u7ecf\u8fc7\u5341\u4f59\u5e74\u7684\u53d1\u5c55\uff0c\u5df2\u7ecf\u4ece\u4f9d\u6258\u5355\u4e00\u6838\u5fc3\u6280\u672f\u5e73\u53f0\u9010\u6b65\u6210\u957f\u4e3a\u62e5\u6709\u56db\u4e2a\u6838\u5fc3\u6280\u672f\u5e73\u53f0\u4ee5\u53ca\u5176\u4ed6\u5173\u952e\u65b0\u836f\u7814\u53d1\u80fd\u529b\u7684\u751f\u7269\u6280\u672f\u516c\u53f8\u3002\u8fd1\u51e0\u5e74\uff0c\u6210\u90fd\u5148\u5bfc\u79ef\u6781\u843d\u5b9e\u63a8\u8fdb\u56f4\u7ed5"\u4e00\u4e2a\u613f\u666f\u3001\u4e24\u5927\u521b\u65b0\u836f\u7c7b\u578b\u3001\u4e09\u79cd\u5546\u4e1a\u6a21\u5f0f\u3001\u56db\u4e2a\u6838\u5fc3\u6280\u672f\u5e73\u53f0"\u7684\u65b0\u53d1\u5c55\u6218\u7565\uff0c\u5229\u7528\u56db\u4e2a\u6838\u5fc3\u6280\u672f\u5e73\u53f0\u53ca\u5176\u4ed6\u5173\u952e\u65b0\u836f\u7814\u53d1\u80fd\u529b\u7684\u534f\u540c\uff0c\u63a2\u7d22\u65b0\u7684\u5546\u4e1a\u8f6c\u5316\u3002\u6301\u7eed\u7684\u6295\u5165\u4e0e\u52aa\u529b\u57282023\u5e74\u8fce\u6765\u9636\u6bb5\u6027\u6210\u6548\uff0c\u516c\u53f8\u4e1a\u52a1"\u591a\u70b9\u5f00\u82b1"\u3002<\/p>\n

DEL\u6280\u672f\u5e73\u53f0\u4f5c\u4e3a\u516c\u53f8\u4e1a\u52a1\u53d1\u5c55\u57fa\u77f3\u7684\u4f5c\u7528\u6301\u7eed\u51f8\u663e\uff0cDEL\u677f\u5757\u6838\u5fc3\u4e1a\u52a1\u57282023\u5e74\u6062\u590d\u663e\u8457\uff0c\u5b9e\u73b0\u6536\u51651.84\u4ebf\u5143\uff0c\u540c\u6bd4\u589e\u52a025.45%\uff1b\u5e76\u57282024\u5e74\u4e00\u5b63\u5ea6\u5ef6\u7eed\u4e86\u6062\u590d\u6027\u589e\u957f\u6001\u52bf\uff0c\u6536\u5165\u540c\u6bd4\u589e\u52a049.33%\u3002\u4e00\u65b9\u9762\uff0c\u516c\u53f8\u79ef\u6781\u54cd\u5e94\u6301\u7eed\u589e\u957f\u7684\u5e02\u573a\u548c\u5408\u4f5c\u4f19\u4f34\u5728\u65b0\u9776\u70b9\u3001\u65b0\u673a\u5236\u63a2\u7d22\u4e2d\u5bf9\u5316\u5408\u7269\u7684\u9700\u6c42\uff0c\u4e0d\u65ad\u5347\u7ea7\u548c\u8fed\u4ee3\u4e07\u4ebf\u7ea7DEL\u5e93\u5316\u5408\u7269\u7ed3\u6784\u7684\u591a\u6837\u6027\u548c\u65b0\u9896\u6027\uff0c\u63d0\u4f9b\u591a\u5143\u5316\u7684\u9ad8\u8d28\u91cfDEL\u7b5b\u9009\u670d\u52a1\u4ee5\u53ca\u7b5b\u9009\u5ef6\u4f38\u670d\u52a1\uff1b\u53e6\u4e00\u65b9\u9762\uff0cDEL\u5e93\u5b9a\u5236\u670d\u52a1\u53d8\u5f97\u66f4\u52a0\u7075\u6d3b\u4e14\u591a\u5143\u5316\uff0c\u516c\u53f8\u73b0\u53ef\u63d0\u4f9b\u9762\u5411\u5927\u578b\u836f\u7269\u516c\u53f8\u7684\u4f20\u7edfDEL\u5b9a\u5236\u5e93\u670d\u52a1\u3001\u9488\u5bf9\u751f\u7269\u6280\u672f\u516c\u53f8\u7684\u5c0f\u578b\u4e13\u6709DEL\u5b9a\u5236\u5e93\u670d\u52a1\u4ee5\u53ca\u4fe1\u606f\u5168\u516c\u5f00\u3001\u53ef\u8986\u76d6\u66f4\u5e7f\u6cdb\u5ba2\u6237\u7fa4\u4f53\u7684OpenDEL™\u81ea\u52a9\u7b5b\u9009\u670d\u52a1\u4ea7\u54c1\u3002<\/p>\n

FBDD\/SBDD\u5e73\u53f0\u57282023\u5e74\u5b9e\u73b0\u8425\u4e1a\u6536\u51659,177.83\u4e07\u5143\uff0c\u540c\u6bd4\u4e0b\u964d11.13%\u3002\u8be5\u5e73\u53f0\u6536\u5165\u4e3b\u8981\u6765\u81ea\u82f1\u56fd\u5b50\u516c\u53f8Vernalis (R&D) Limited\u30022023\u5e74\uff0cVernalis\u53d7\u5176\u5ba2\u6237\u7814\u53d1\u6218\u7565\u8c03\u6574\u7684\u5f71\u54cd\uff0c\u6536\u5165\u4e0d\u53ca\u9884\u671f\uff0c\u5e26\u52a8FBDD\/SBDD\u5e73\u53f0\u6574\u4f53\u6536\u5165\u6709\u6240\u4e0b\u964d\u3002\u4f46Vernalis\u4f5c\u4e3aFBDD\/SBDD\u6280\u672f\u9886\u57df\u7684\u56fd\u9645\u9886\u5148\u8005\uff0c\u6709\u7740\u6df1\u539a\u7684\u4e13\u957f\u548c\u6280\u672f\u79ef\u6dc0\uff0c\u662f\u516c\u53f8\u836f\u7269\u53d1\u73b0\u4e0e\u4f18\u5316\u6280\u672f\u7248\u56fe\u7684\u91cd\u8981\u4e00\u5757\uff0c2024\u5e74\u4e00\u5b63\u5ea6\uff0cVernalis\u83b7\u5f97\u9879\u76ee\u91cc\u7a0b\u7891\u6536\u5165\uff0c\u5e26\u52a8FBDD\/SBDD\u5e73\u53f0\u6536\u5165\u540c\u6bd4\u589e\u52a078.83%\u3002<\/p>\n

STO\u6280\u672f\u5e73\u53f0\u57fa\u4e8e\u6838\u9178\u836f\u7684\u4e00\u7ad9\u5f0f\u670d\u52a1\uff08\u5305\u62ec\u9012\u9001\u5206\u5b50\u5408\u6210\u3001\u5be1\u6838\u82f7\u9178\/\u7279\u6b8a\u5355\u4f53\u7684\u8bbe\u8ba1\u3001\u4fee\u9970\u548c\u5408\u6210\u3001\u6838\u9178\u836f\u7269\u76f8\u5173\u7684\u4f53\u5185\u5916\u8bc4\u4ef7\u7b49\uff09\u57282023\u5e74\u5b9e\u73b0\u8425\u4e1a\u6536\u51653,437.78\u4e07\u5143\uff0c\u540c\u6bd4\u4e0b\u964d10.62%\u3002\u9700\u8981\u8bf4\u660e\u7684\u662f\uff0c\u8be5\u5e73\u53f0\u6574\u4f53\u6536\u5165\u8f832022\u5e74\u6709\u6240\u51cf\u5c11\uff0c\u4e3b\u8981\u662f\u7531\u4e8e2022\u5e74\u5e73\u53f0\u4ea7\u751f\u4e86\u6838\u9178\u65b0\u836f\u7ba1\u7ebf\u8f6c\u8ba9\u9879\u76ee\u6536\u5165\uff0c\u82e5\u5254\u9664\u6b64\u90e8\u5206\u6536\u5165\u7684\u56e0\u7d20\uff0cSTO\u5e73\u53f0\u57282023\u5e74\u7684\u670d\u52a1\u6536\u5165\u5219\u540c\u6bd4\u5b9e\u73b0\u4e8660.16%\u7684\u5f3a\u52b2\u589e\u957f\uff0c\u5448\u73b0\u51fa\u826f\u597d\u7684\u589e\u957f\u6001\u52bf\u3002<\/p>\n

TPD\u6280\u672f\u5e73\u53f0\u7684\u589e\u957f\u6f5c\u529b\u9010\u6e10\u663e\u73b0\uff0c\u57282023\u5e74\u5b9e\u73b0\u8425\u4e1a\u6536\u51651,852.50\u4e07\u5143\uff0c\u540c\u6bd4\u589e\u957f111.85%\uff0c\u5305\u62ecE3\u914d\u4f53\u53d1\u73b0\u3001\u5206\u5b50\u80f6\u7b5b\u9009\u3001PROTAC\u5206\u5b50\u5408\u6210\u4e0e\u751f\u7269\u8bc4\u4ef7\u7b49\u76f8\u5173\u670d\u52a1\u5e26\u6765\u7684\u6536\u5165\u3002<\/p>\n

\u5176\u4ed6\u5173\u952e\u65b0\u836f\u7814\u53d1\u80fd\u529b\u4ea6\u9010\u6e10\u5f00\u59cb\u663e\u793a\u5546\u4e1a\u4ef7\u503c\u30022023\u5e74\uff0c\u57fa\u4e8e\u5c0f\u5206\u5b50\u836f\u7269\u76f8\u5173\u751f\u7269\u4f53\u5185\/\u4f53\u5916\u8bc4\u4ef7\u3001ADME\/DMPK\u7b49\u7684\u751f\u7269\u5b66\u670d\u52a1\uff08BioSer\uff09\u5b9e\u73b0\u8425\u4e1a\u6536\u51651,587.59\u4e07\u5143\uff0c\u540c\u6bd4\u4e0a\u5347544.41%\uff1b\u57fa\u4e8e\u5c0f\u5206\u5b50\u5316\u5b66\u5408\u6210\u3001\u5e73\u884c\u5408\u6210\u7b49\u7684\u5316\u5b66\u670d\u52a1\uff08ChemSer\uff09\u5b9e\u73b0\u8425\u4e1a\u6536\u51651,579.19\u4e07\u5143\uff0c\u540c\u6bd4\u4e0a\u5347231.43%\uff1b\u65b0\u836f\u5b9a\u5236\u9879\u76ee\u670d\u52a1\uff08IDD\uff09\u3001\u5176\u4ed6\u670d\u52a1\uff08Others\uff09\u3001\u65b0\u836f\u5728\u7814\u9879\u76ee\u6743\u76ca\u8f6c\u8ba9\uff08POL\uff09\u5206\u522b\u5b9e\u73b0\u6536\u5165687.51\u4e07\u5143\u3001237.40\u4e07\u5143\u3001188.68\u4e07\u5143\u3002<\/p>\n

2023\u5e74\uff0c\u6210\u90fd\u5148\u5bfc\u548c\u82f1\u56fd\u5b50\u516c\u53f8Vernalis\u4e0e\u5168\u7403\u591a\u5bb6\u751f\u7269\u5236\u836f\u516c\u53f8\u548c\u7814\u7a76\u673a\u6784\u8fbe\u6210\u6df1\u5ea6\u5408\u4f5c\uff0c\u90e8\u5206\u516c\u5f00\u62ab\u9732\u7684\u65b0\u7b7e\u5408\u4f5c\u4f19\u4f34\u5305\u62ecARase Therapeutics\u3001Nested Therapeutics\u3001Pierre Fabre Laboratories\u3001Structural Genomics Consortium\u3001\u957f\u6625\u91d1\u8d5b\u836f\u4e1a\u3001\u5e7f\u4e1c\u4f17\u751f\u777f\u521b\u3001\u5317\u4eac\u536b\u4fe1\u5eb7\u7b49\u3002<\/p>\n

\u7814\u53d1\uff1a\u57fa\u4e8e<\/b>DEL<\/b>\u6280\u672f\u7684\u521b\u65b0\u80fd\u529b\u77e9\u9635\uff0c\u7531\u70b9\u6269\u9762\u7b51\u7262\u53d1\u5c55\u57fa\u7840<\/b><\/p>\n

\u4f5c\u4e3a\u4e00\u5bb6\u7814\u53d1\u9a71\u52a8\u578b\u751f\u7269\u533b\u836f\u4f01\u4e1a\uff0c\u6210\u90fd\u5148\u5bfc\u6bcf\u5e74\u5728DEL\u3001FBDD\/SBDD\u3001STO\u3001TPD\u56db\u4e2a\u6838\u5fc3\u6280\u672f\u5e73\u53f0\u3001\u5176\u4ed6\u5173\u952e\u65b0\u836f\u7814\u53d1\u80fd\u529b\u4ee5\u53ca\u65b0\u836f\u7ba1\u7ebf\u4e0a\u6301\u7eed\u6295\u5165\uff0c\u4e0d\u65ad\u5b8c\u5584\u65b0\u836f\u53d1\u73b0\u4e0e\u4f18\u5316\u80fd\u529b\uff0c\u5e76\u5728\u6b64\u57fa\u7840\u4e0a\u642d\u5efa\u8d77\u4e86"\u4e00\u7ad9\u5f0f"\u4ece\u9776\u57fa\u56e0\u5230\u65b0\u836f\u4e34\u5e8a\u8bd5\u9a8c\u7533\u8bf7\u9636\u6bb5\u7684\u836f\u7269\u53d1\u73b0\u4e0e\u4f18\u5316\u4f53\u7cfb\u30022023\u5e74\uff0c\u516c\u53f8\u7814\u53d1\u6295\u51657,961.08\u4e07\u5143\uff0c\u5360\u8425\u4e1a\u6536\u5165\u6bd4\u4f8b21.44%\uff0c\u540c\u6bd4\u51cf\u5c115.06\u4e2a\u767e\u5206\u70b9\uff0c\u4e3b\u8981\u7531\u4e8e\u516c\u53f8\u57fa\u4e8e\u8425\u8fd0\u73b0\u91d1\u6d41\u5e73\u8861\u7684\u89d2\u5ea6\u5ba1\u614e\u8003\u8651\uff0c\u5bf9\u81ea\u7814\u7ba1\u7ebf\u9879\u76ee\u8fdb\u884c\u4e86\u805a\u7126\u8c03\u6574\u30022024\u5e74\uff0c\u516c\u53f8\u7ee7\u7eed\u805a\u7126\u8c03\u6574\u81ea\u7814\u7ba1\u7ebf\u9879\u76ee\uff0c\u540c\u65f6\u968f\u7740\u6838\u5fc3\u6280\u672f\u5e73\u53f0\u80fd\u529b\u5efa\u8bbe\u9010\u6b65\u5b8c\u5584\uff0c\u5e73\u53f0\u4e1a\u52a1\u91cd\u5fc3\u5411\u5546\u4e1a\u9879\u76ee\u6709\u6240\u504f\u79fb\uff0c\u4e00\u5b63\u5ea6\u81ea\u7814\u9879\u76ee\u7814\u53d1\u8d39\u7528\u964d\u81f31,298.92\u4e07\u5143\uff0c\u53e0\u52a0\u540c\u671f\u516c\u53f8\u8425\u6536\u5b9e\u73b0\u540c\u6bd4\u8f83\u5927\u5e45\u5ea6\u589e\u957f\u7684\u56e0\u7d20\uff0c\u4e00\u5b63\u5ea6\u7814\u53d1\u6295\u5165\u5360\u8425\u6536\u6bd4\u4f8b\u4e3a12.10%\u3002<\/p>\n

\u6210\u90fd\u5148\u5bfc\u4e00\u76f4\u81f4\u529b\u4e8e\u6838\u5fc3\u6280\u672f\u2014\u2014DNA\u7f16\u7801\u5316\u5408\u7269\u5e93\uff08DEL\uff09\u6280\u672f\u7684\u5f00\u53d1\u3001\u5e94\u7528\u548c\u5347\u7ea7\u30022023\u5e74\uff0c\u516c\u53f8\u7684DEL\u6838\u5fc3\u6280\u672f\u5e73\u53f0\u5b9e\u73b0\u4e86\u5feb\u901f\u8fed\u4ee3\uff0c\u4e3a\u6301\u7eed\u8f93\u51fa\u4e0d\u540c\u9636\u6bb5\u7684\u65b0\u5206\u5b50\u5b9e\u4f53\u63d0\u4f9b\u4e86\u53ef\u9760\u7684\u6280\u672f\u4fdd\u969c\uff1a\u4e00\u662fDEL\u5e93\u7ed3\u6784\u5206\u5b50\u66f4\u52a0\u591a\u6837\u5316\uff0c\u6db5\u76d6\u5171\u4ef7\u5316\u5408\u7269\u3001\u86cb\u767d\u964d\u89e3\u5316\u5408\u7269\u3001\u5206\u5b50\u7247\u6bb5\u5316\u5408\u7269\u3001\u5927\u73af\u5316\u5408\u7269\u3001\u591a\u80bd\u5316\u5408\u7269\uff0c\u53ef\u4e3a\u8ffd\u8e2a\u521b\u65b0\u836f\u524d\u6cbf\u7814\u7a76\u7684\u5236\u836f\u4f01\u4e1a\u548c\u751f\u7269\u6280\u672f\u516c\u53f8\u63d0\u4f9b\u72ec\u7279\u7684\u65b0\u5206\u5b50\u5b9e\u4f53\uff1b\u540c\u65f6\uff0c\u5408\u6210\u5206\u5b50\u9aa8\u67b6\u7684\u79cd\u7c7b\u8d85\u8fc76,000\u79cd\uff0c\u57fa\u672c\u6db5\u76d6\u4e86\u6240\u6709\u5f53\u524d\u5df2\u83b7\u6279\u4e0a\u5e02\u7684\u5c0f\u5206\u5b50\u836f\u7269\u7684\u6838\u5fc3\u9aa8\u67b6\u4ee5\u53ca\u4e34\u5e8a\u5728\u7814\u5c0f\u5206\u5b50\u9879\u76ee\u7684\u5927\u591a\u6570\u4f18\u52bf\u9aa8\u67b6\uff1bDNA\u517c\u5bb9\u7684\u5316\u5b66\u53cd\u5e94\u8d85\u8fc7150\u79cd\uff0c\u8986\u76d6\u4e86\u7edd\u5927\u90e8\u5206\u836f\u7269\u5316\u5b66\u5408\u6210\u7684\u5e38\u89c1\u5316\u5b66\u53cd\u5e94\u3002\u4e8c\u662fDEL\u6280\u672f\u7684\u8d28\u91cf\u548c\u6548\u7387\u4e0d\u65ad\u63d0\u5347\uff0c\u901a\u8fc7\u65b0\u63a8\u51fa\u7684"DEL For"\u7cfb\u5217\u8fdb\u4e00\u6b65\u6269\u5c55DEL\u6280\u672f\u7684\u9002\u7528\u8303\u56f4\uff0c\u5e94\u7528\u81f3\u66f4\u591a\u7c7b\u578b\u7684\u9776\u70b9\u548c\u751f\u7269\u673a\u5236\u7684\u7b5b\u9009\uff0c\u4ee5\u53ca\u901a\u8fc7"DEL Plus"\uff08\u5305\u542bDEL+Protein\u3001DEL+Assay\u3001DEL+AI\/ML\u7b49\uff09\u4e3a\u5408\u4f5c\u4f19\u4f34\u5728\u86cb\u767d\u83b7\u53d6\u3001\u5316\u5408\u7269\u8bc4\u4ef7\u3001\u7b5b\u9009\u5206\u5b50\u6269\u5c55\u7b49\u9886\u57df\u63d0\u4f9b\u65e0\u7f1d\u8fde\u63a5\u3002\u622a\u81f32023\u5e74\uff0c\u516c\u53f8\u7d2f\u8ba1\u7b5b\u9009\u9776\u70b9\u8d85\u8fc753\u7c7b\u3001\u6570\u767e\u4e2a\u9776\u70b9\uff0c\u5305\u62ec\u5404\u79cd\u65b0\u9896\u9776\u70b9\u6216\u6311\u6218\u6027\u9776\u70b9\uff0c\u8fd1\u4e09\u5e74\u7684\u9879\u76ee\u5e73\u5747\u7b5b\u9009\u6210\u529f\u7387\uff08\u83b7\u5f97\u529f\u80fd\u6027\u7684\u5206\u5b50\uff09\u8d85\u8fc775%\uff0c\u7b5b\u9009\u9879\u76ee\u5e73\u5747\u5468\u671f\u7f29\u77ed\u81f33\u4e2a\u6708\u4ee5\u5185\uff0c\u7d2f\u8ba1\u5b8c\u621086\u4e2a\u9879\u76ee\uff08\u8d85\u8fc7800\u4e2a\u5316\u5408\u7269\u5b9e\u4f53\u5206\u5b50\uff09\u7684\u5316\u5408\u7269\u77e5\u8bc6\u4ea7\u6743\u8f6c\u8ba9\u3002<\/p>\n

FBDD\/SBDD\u5e73\u53f0\u901a\u8fc7DEL\u6280\u672f\u6269\u5c55Vernalis\u81ea\u6709\u53ef\u4f9b\u7b5b\u9009\u7684"\u5206\u5b50\u6a21\u5757\u5e93"\uff0c\u5206\u5b50\u7247\u6bb5\u603b\u6570\u5df2\u8d85\u8fc74\u4e07\u79cd\uff0c\u53ef\u9ad8\u6548\u5feb\u901f\u5730\u9488\u5bf9\u4e0d\u540c\u9776\u70b9\u8fdb\u884c\u7247\u6bb5\u7684\u53d1\u73b0\u3002\u540c\u65f6\uff0c\u5229\u7528\u591a\u6837\u5316\u7684DEL\u4e2d\u95f4\u4f53\u4f18\u5316\u5206\u5b50\u7247\u6bb5\uff0c\u53ef\u57281\u4e2a\u6708\u5185\u5c06\u6beb\u6469\u5c14\uff08mM\uff09\u7ea7\u522b\u7684\u5206\u5b50\u7247\u6bb5\u4f18\u5316\u4e3a\u7eb3\u6469\u5c14\uff08nM\uff09\u7ea7\u522b\u7684\u82d7\u5934\u5316\u5408\u7269\uff0c\u5927\u5927\u7f29\u77ed\u4f20\u7edf\u7684\u5206\u5b50\u7247\u6bb5\u4f18\u5316\u8fc7\u7a0b\u3002<\/p>\n

\u4e0e\u6b64\u540c\u65f6\uff0c\u516c\u53f8\u4ea6\u79ef\u6781\u5efa\u8bbe\u57fa\u4e8eDEL\u6280\u672f\u884d\u751f\u5f00\u62d3\u7684STO\u4ee5\u53caTPD\u6838\u5fc3\u6280\u672f\u5e73\u53f0\u3002STO\u5e73\u53f0\u5efa\u8bbe\u8fdb\u5c55\u8fc5\u901f\uff0c\u53ef\u652f\u6301\u4ece\u9776\u70b9\u5230\u4e34\u5e8a\u7533\u62a5\u9636\u6bb5\u7684\u6838\u9178\u836f\u7269\u53d1\u73b0\u53ca\u5f00\u53d1\u3002\u622a\u81f32023\u5e74\uff0c\u516c\u53f8\u5df2\u5f00\u53d1\u4e86\u591a\u79cd\u81ea\u4e3b\u77e5\u8bc6\u4ea7\u6743\u7684\u6838\u9178\u836f\u7269\u9012\u9001\u7cfb\u7edf\uff0c\u5305\u62ec\u809d\u5185\u9776\u5411\u7684GalNAc\u548c\u57fa\u4e8eC16\u7684\u809d\u5916\u9012\u9001\u5206\u5b50\u7b49\uff1b\u63a7\u80a1\u5b50\u516c\u53f8\u56db\u5ddd\u5148\u4e1c\u5236\u836f\u6709\u9650\u516c\u53f8\u542f\u52a8\u8fd0\u8425, \u53ef\u63d0\u4f9b\u5c0f\u6838\u9178\u7684GMP\u751f\u4ea7\u670d\u52a1\u3002TPD\u5e73\u53f0\u65b9\u9762\uff0c\u622a\u81f32023\u5e74\uff0c\u516c\u53f8\u5df2\u7d2f\u8ba1\u5b8c\u6210\u8d85\u8fc750\u4e2a\u65b0\u9896E3\u6cdb\u7d20\u8fde\u63a5\u9176\uff08\u5927\u4e8e100\u4e2aProtein Constructs\uff08\u86cb\u767d\u8d28\u6784\u5efa\u4f53\uff09\uff09\u7684\u5236\u5907\uff0c\u53ef\u4f9b\u5ba2\u6237\u8fdb\u884c\u76f4\u63a5\u8ba2\u8d2d\u5e76\u8fdb\u884cDEL\u7b5b\u9009\u548c\u5316\u5408\u7269\u5408\u6210\u4e0e\u8bc4\u4ef7\uff1b\u540c\u65f6\u4ee5\u81ea\u4e3b\u5f00\u53d1\u6216\u5408\u4f5c\u65b9\u5f0f\u9488\u5bf9\u8fd9\u4e9b\u65b0\u9896E3\u6cdb\u7d20\u8fde\u63a5\u9176\u53ca\u914d\u4f53\u8fdb\u884c\u86cb\u767d\u964d\u89e3\u5242\u7684\u5f00\u53d1\uff0c\u6bd4\u5982TRIM21\u914d\u4f53\u7684PROTAC\u5f00\u53d1\uff0c\u53e6\u5916\uff0cTRIM21\u914d\u4f53\u5177\u6709\u5f00\u53d1\u6210\u5206\u5b50\u80f6\u7684\u6f5c\u529b\uff0c\u516c\u53f8\u6b63\u8fdb\u884c\u8fdb\u4e00\u6b65\u673a\u5236\u63a2\u7d22\u3002<\/p>\n

\u516c\u53f8\u56f4\u7ed5\u56db\u4e2a\u6838\u5fc3\u6280\u672f\u5e73\u53f0\u642d\u5efa\u4e86"\u4e00\u7ad9\u5f0f"\u4ece\u9776\u57fa\u56e0\u5230\u65b0\u836f\u4e34\u5e8a\u8bd5\u9a8c\u7533\u8bf7\u9636\u6bb5\u7684\u836f\u7269\u53d1\u73b0\u4e0e\u4f18\u5316\u4f53\u7cfb\uff0c\u8986\u76d6\u8303\u56f4\u5305\u62ec\u91cd\u7ec4\u86cb\u767d\u8868\u8fbe\u7eaf\u5316\u3001\u7ed3\u6784\u751f\u7269\u5b66\u3001\u8ba1\u7b97\u5316\u5b66\u4e0e\u836f\u7269\u5316\u5b66\u3001\u751f\u7269\u5316\u5b66\u548c\u751f\u7269\u7269\u7406\u5b66\u3001\u7ec6\u80de\u751f\u7269\u5b66\u3001\u4f53\u5185\u836f\u7406\u5b66\u3001\u836f\u4ee3\u52a8\u529b\u5b66\u3001\u836f\u5b66\u7814\u7a76\u7b49\u591a\u4e2a\u6280\u672f\u73af\u8282\uff0c\u80fd\u591f\u9488\u5bf9\u591a\u79cd\u751f\u7269\u673a\u5236\u548c\u9776\u70b9\u7c7b\u522b\u8fdb\u884c\u65b0\u5206\u5b50\u7684\u53d1\u73b0\u548c\u540e\u7eed\u5f00\u53d1\uff0c\u76f4\u81f3\u63a8\u8fdb\u5230\u4e34\u5e8a\u524d\u5019\u9009\u7269\u9636\u6bb5\u751a\u81f3\u4e34\u5e8a\u8bd5\u9a8c\u9636\u6bb5\u3002<\/p>\n

\u65b0\u836f\u7ba1\u7ebf\u65b9\u9762\uff0c\u516c\u53f8\u57fa\u4e8e\u8425\u8fd0\u73b0\u91d1\u6d41\u5e73\u8861\u7684\u89d2\u5ea6\u5ba1\u614e\u8003\u8651\uff0c\u5bf9\u81ea\u7814\u7ba1\u7ebf\u9879\u76ee\u8fdb\u884c\u4e86\u805a\u7126\u8c03\u6574\uff0c\u622a\u81f32023\u5e74\u672b\u67093\u4e2a\u9879\u76ee\u5904\u4e8eI\u671f\u4e34\u5e8a\u9636\u6bb5\uff0c2\u4e2a\u9879\u76ee\u5904\u4e8eIND\u7533\u62a5\u51c6\u5907\u9636\u6bb5\uff0c2\u4e2a\u5904\u4e8e\u4e34\u5e8a\u524d\u5019\u9009\u5316\u5408\u7269\uff08PCC\uff09\u7b5b\u9009\u9636\u6bb5\u3002\u53e6\u6709\u82e5\u5e72\u4e2a\u65e9\u671f\u9879\u76ee\u5206\u522b\u5904\u4e8e\u9776\u70b9\u9a8c\u8bc1\u3001\u82d7\u5934\u5316\u5408\u7269\u7684\u7b5b\u9009\u4ee5\u53ca\u7ed3\u6784\u4f18\u5316\u9636\u6bb5\u3002<\/p>\n

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\u53e6\u4e00\u65b9\u9762\uff0c\u516c\u53f8\u5c06\u7ee7\u7eed\u63a8\u8fdb"DEL+AI"\u7684\u9879\u76ee\u7814\u53d1\u53ca\u80fd\u529b\u5efa\u8bbe\uff0c\u7ed3\u5408DEL\u6570\u636e\u79ef\u7d2f\u548cAI\u6280\u672f\u5f00\u53d1\u4e0b\u4e00\u4ee3\u63a2\u7d22\u5316\u5408\u7269\u7a7a\u95f4\u7684\u65b9\u6cd5\uff0c\u5e76\u5229\u7528\u5185\u90e8\u7684\u9ad8\u901a\u91cf\u5316\u5b66\u5408\u6210\u548c\u9ad8\u901a\u91cf\u5316\u5408\u7269\u68c0\u6d4b\u5e73\u53f0\uff0c\u901a\u8fc7\u8fed\u4ee3\u5f0f\u7684"\u8bbe\u8ba1-\u5408\u6210-\u6d4b\u8bd5-\u5206\u6790"\uff08DMTA\uff09\u5faa\u73af\u6a21\u5f0f\u52a0\u901f\u4e34\u5e8a\u524d\u5019\u9009\u836f\u7269\u53d1\u73b0\u53ca\u4f18\u5316\u3002<\/p>\n

*\u4e13\u6709\u540d\u8bcd\u6ce8\u91ca\uff1a<\/p>\n