{"id":111966,"date":"2024-04-23T17:05:00","date_gmt":"2024-04-23T10:05:00","guid":{"rendered":"https:\/\/www.xinwengao.com\/cn\/pr\/20240423170500111966"},"modified":"2024-04-24T12:04:46","modified_gmt":"2024-04-24T04:04:46","slug":"%e7%99%be%e6%b5%8e%e7%a5%9e%e5%b7%9e%e6%9b%bf%e9%9b%b7%e5%88%a9%e7%8f%a0%e5%8d%95%e6%8a%97%e8%8e%b7%e6%ac%a7%e7%9b%9f%e5%a7%94%e5%91%98%e4%bc%9a%e6%89%b9%e5%87%86%e7%94%a8%e4%ba%8e%e6%b2%bb%e7%96%97","status":"publish","type":"post","link":"https:\/\/www.xinwengao.com\/cn\/pr\/20240423170500111966","title":{"rendered":"\u767e\u6d4e\u795e\u5dde\u66ff\u96f7\u5229\u73e0\u5355\u6297\u83b7\u6b27\u76df\u59d4\u5458\u4f1a\u6279\u51c6\u7528\u4e8e\u6cbb\u7597\u975e\u5c0f\u7ec6\u80de\u80ba\u764c"},"content":{"rendered":"<p class=\"prntac\"><i>\u5305\u542b\u4e09\u9879<\/i><i>3<\/i><i>\u671f\u4e34\u5e8a\u8bd5\u9a8c\u7684\u7efc\u5408\u5f00\u53d1\u8ba1\u5212\u8bc1\u660e\u66ff\u96f7\u5229\u73e0\u5355\u6297\u4e3a\u521d\u6cbb\u548c\u590d\u53d1\u6027\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u60a3\u8005\u5e26\u6765\u83b7\u76ca<\/i><\/p>\n<p class=\"prntac\"><i>\u6b64\u51b3\u5b9a\u662f\u66ff\u96f7\u5229\u73e0\u5355\u6297\u5728\u8be5\u5730\u533a\u83b7\u5f97\u7684\u7b2c\u4e8c\u9879\u6279\u51c6<\/i><\/p>\n<p><p><span class=\"legendSpanClass\">\u4e2d\u56fd\u5317\u4eac\u3001\u7f8e\u56fd\u9ebb\u7701\u5251\u6865\u548c\u745e\u58eb\u5df4\u585e\u5c14<\/span><span class=\"legendSpanClass\">2024\u5e744\u670823\u65e5<\/span> \/\u7f8e\u901a\u793e\/ &#8212; \u767e\u6d4e\u795e\u5dde\uff08\u7eb3\u65af\u8fbe\u514b\u4ee3\u7801\uff1a BGNE\uff1b\u9999\u6e2f\u8054\u4ea4\u6240\u4ee3\u7801\uff1a06160\uff1b\u4e0a\u4ea4\u6240\u4ee3\u7801\uff1a688235\uff09\u662f\u4e00\u5bb6\u5168\u7403\u80bf\u7624\u521b\u65b0\u516c\u53f8\uff0c\u4eca\u65e5\u5ba3\u5e03\u6b27\u76df\u59d4\u5458\u4f1a\uff08EC\uff09\u5df2\u6279\u51c6\u66ff\u96f7\u5229\u73e0\u5355\u6297\u7528\u4e8e\u4e09\u9879\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff08NSCLC\uff09\u9002\u5e94\u75c7\u7684\u4e00\u7ebf\u53ca\u4e8c\u7ebf\u6cbb\u7597\u3002<\/p>\n<p>\u767e\u6d4e\u795e\u5dde\u5b9e\u4f53\u80bf\u7624\u9996\u5e2d\u533b\u5b66\u5b98Mark Lanasa\u533b\u5b66\u535a\u58eb\u8868\u793a\uff1a&quot;\u66ff\u96f7\u5229\u73e0\u5355\u6297\u662f\u767e\u6d4e\u795e\u5dde\u5b9e\u4f53\u80bf\u7624\u4ea7\u54c1\u7ec4\u5408\u7684\u57fa\u7840\uff0c\u5e76\u5df2\u5728NSCLC\u7b49\u591a\u79cd\u80bf\u7624\u7c7b\u578b\u4e2d\u5c55\u73b0\u51fa\u6f5c\u529b\u3002\u5728NSCLC\u7684\u6240\u6709\u75be\u75c5\u9636\u6bb5\u5747\u6709\u8bb8\u591a\u5c1a\u672a\u88ab\u6ee1\u8db3\u7684\u9700\u6c42\u3002\u6b64\u6b21EC\u7684\u51b3\u5b9a\u6807\u5fd7\u7740\u66ff\u96f7\u5229\u73e0\u5355\u6297\u5728\u8be5\u5730\u533a\u83b7\u5f97\u7b2c\u4e8c\u9879\u6279\u51c6\uff0c\u5728\u6b27\u76df\u5730\u533a\uff0c\u66ff\u96f7\u5229\u73e0\u5355\u6297\u53ef\u7528\u4e8e\u6cbb\u7597NSCLC\u548c\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u98df\u7ba1\u9cde\u72b6\u7ec6\u80de\u764c\uff08ESCC\uff09\u3002\u5728\u51e0\u5468\u524d\uff0c\u7f8e\u56fd\u98df\u54c1\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08FDA\uff09\u6279\u51c6\u4e86\u66ff\u96f7\u5229\u73e0\u5355\u6297\u7528\u4e8eESCC\u7684\u4e8c\u7ebf\u6cbb\u7597\uff0c\u8fd9\u4f7f\u6211\u4eec\u80fd\u591f\u66f4\u597d\u5730\u5c65\u884c\u627f\u8bfa\uff0c\u5c06\u8fd9\u4e00\u521b\u65b0\u7597\u6cd5\u5e26\u7ed9\u5168\u4e16\u754c\u66f4\u591a\u60a3\u8005\u3002&quot;<\/p>\n<p>\u66ff\u96f7\u5229\u73e0\u5355\u6297\u672c\u6b21\u83b7\u6279\u9002\u5e94\u75c7\u4e3a\uff1a<\/p>\n<ul type=\"disc\">\n<li>\u8054\u5408\u7d2b\u6749\u9187\u548c\u5361\u94c2\u6216\u6ce8\u5c04\u7528\u7d2b\u6749\u9187\uff08\u767d\u86cb\u767d\u7ed3\u5408\u578b\uff09\u548c\u5361\u94c2\u7528\u4e8e\u4e0d\u9002\u5408\u624b\u672f\u5207\u9664\u6216\u63a5\u53d7\u542b\u94c2\u653e\u5316\u7597\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u9cde\u72b6\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u6210\u4eba\u60a3\u8005\u7684\u4e00\u7ebf\u6cbb\u7597\uff1b<\/li>\n<li>\u8054\u5408\u57f9\u7f8e\u66f2\u585e\u548c\u94c2\u7c7b\u5316\u7597\u7528\u4e8ePD-L1\u8868\u8fbe\u226550%\u4e14\u65e0\u8868\u76ae\u751f\u957f\u56e0\u5b50\u53d7\u4f53\uff08EGFR\uff09\u6216\u95f4\u53d8\u6027\u6dcb\u5df4\u7624\u6fc0\u9176\uff08ALK\uff09\u9633\u6027\u7a81\u53d8\u3001\u4e0d\u9002\u5408\u624b\u672f\u5207\u9664\u6216\u63a5\u53d7\u542b\u94c2\u653e\u5316\u7597\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u975e\u9cde\u72b6\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u6210\u4eba\u60a3\u8005\u7684\u4e00\u7ebf\u6cbb\u7597\uff1b<\/li>\n<li>\u5355\u836f\u7528\u4e8e\u6cbb\u7597\u65e2\u5f80\u63a5\u53d7\u542b\u94c2\u836f\u7269\u6cbb\u7597\u540e\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027NSCLC\u6210\u4eba\u60a3\u8005\u3002EGFR\u7a81\u53d8\u6216ALK\u7a81\u53d8\u9633\u6027\u7684NSCLC\u60a3\u8005\u5728\u63a5\u53d7\u66ff\u96f7\u5229\u73e0\u5355\u6297\u6cbb\u7597\u524d\u5e94\u5f53\u5df2\u63a5\u53d7\u8fc7\u9776\u5411\u6cbb\u7597\u3002<\/li>\n<\/ul>\n<p>\u897f\u73ed\u7259\u9a6c\u5fb7\u91ccHospital Universitario 12 de Octubre\u533b\u9662\u80bf\u7624\u5185\u79d1\u4e3b\u4efbLuis Paz-Ares \u533b\u5b66\u535a\u58eb\u8868\u793a\uff1a&quot;\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u4ecd\u7136\u662f\u6b27\u6d32\u6700\u5e38\u89c1\u548c\u81f4\u547d\u7684\u764c\u75c7\u4e4b\u4e00\uff0c\u6709\u4e00\u534a\u60a3\u8005\u5728\u786e\u8bca\u65f6\u5c31\u5df2\u7ecf\u8fdb\u5c55\u81f3\u665a\u671f\uff0c\u56e0\u6b64\u6cbb\u7597\u96be\u5ea6\u5f88\u5927\u3002\u5728\u8fd9\u4e09\u9879 3 \u671f\u7814\u7a76\u4e2d\uff0c\u66ff\u96f7\u5229\u73e0\u5355\u6297\u5df2\u8bc1\u660e\u53ef\u4ee5\u6539\u5584\u7279\u5b9a\u7c7b\u578bNSCLC\u60a3\u8005\u7684\u6cbb\u7597\u7ed3\u679c\uff0c\u4e3a\u60a3\u8005\u63d0\u4f9b\u4e86\u65b0\u7684\u9009\u62e9\u3002&quot;<\/p>\n<p>\u88ab\u6279\u51c6\u7528\u4e8e\u4e0a\u8ff0NSCLC\u9002\u5e94\u75c7\u7684\u66ff\u96f7\u5229\u73e0\u5355\u6297\u5546\u54c1\u540d\u4e3aTIZVENI<sup>&reg;<\/sup>\u3002\u767e\u6d4e\u795e\u5dde\u8ba1\u5212\u5c06NSCLC\u9002\u5e94\u75c7\u4e0eESCC\u4e8c\u7ebf\u6cbb\u7597\u9002\u5e94\u75c7\u7edf\u4e00\u5408\u5e76\u81f3\u5546\u54c1\u540dTEVIMBRA<sup>&reg;<\/sup>\u4e0b\uff0cTEVIMBRA<sup>&reg;<\/sup>\u5c06\u4e8e2024\u5e74\u665a\u4e9b\u65f6\u5019\u5728\u9996\u6279\u6b27\u76df\u56fd\u5bb6\u4e0a\u5e02\u3002TEVIMBRA<sup>&reg;<\/sup>\u5df2\u5728\u7f8e\u56fd\u548c\u6b27\u76df\u83b7\u6279\u7528\u4e8e\u6cbb\u7597\u65e2\u5f80\u63a5\u53d7\u5316\u7597\u7684\u665a\u671f\u6216\u8f6c\u79fb\u6027ESCC\u60a3\u8005\uff0c\u8be5\u836f\u54c1\u540c\u65f6\u8fd8\u5728\u63a5\u53d7\u6b27\u6d32\u836f\u54c1\u7ba1\u7406\u5c40\uff08EMA\uff09\u548cFDA\u5ba1\u8bc4\uff0c\u7528\u4e8e\u4e0d\u53ef\u5207\u9664\u3001\u590d\u53d1\u3001\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027ESCC\u60a3\u8005\u7684\u4e00\u7ebf\u6cbb\u7597\uff0c\u4ee5\u53ca\u80c3\u6216\u80c3\u98df\u7ba1\u7ed3\u5408\u90e8\u817a\u764c\u60a3\u8005\u7684\u4e00\u7ebf\u6cbb\u7597\u3002<\/p>\n<p>EC\u672c\u6b21\u7684\u6279\u51c6\u57fa\u4e8e\u4e09\u98793 \u671fRATIONALE\u4e34\u5e8a\u7814\u7a76\u7ed3\u679c\uff0c\u8be5\u90e8\u5206\u7814\u7a76\u5171\u5165\u7ec41,499\u540d\u60a3\u8005\uff1a<\/p>\n<ul type=\"disc\">\n<li>RATIONALE 307\uff08<a href=\"https:\/\/clinicaltrials.gov\/study\/NCT03594747?term=NCT03594747&amp;limit=10&amp;rank=1\" target=\"_blank\" rel=\"nofollow noopener\">NCT03594747<\/a>\uff09\u662f\u4e00\u9879\u5f00\u653e\u6027\u3001\u968f\u673a\u30013\u671f\u8bd5\u9a8c\uff0c\u5171\u5165\u7ec4360\u4f8b\u665a\u671f\u9cde\u72b6NSCLC\u60a3\u8005\u3002\u8be5\u7814\u7a76\u8fbe\u5230\u4e3b\u8981\u7ec8\u70b9\uff0c\u5373\u65e0\u8bbaPD-L1\u8868\u8fbe\u6c34\u5e73\u5982\u4f55\uff0c\u66ff\u96f7\u5229\u73e0\u5355\u6297\u8054\u5408\u5316\u7597\u4f5c\u4e3a\u4e00\u7ebf\u6cbb\u7597\u5747\u53ef\u83b7\u5f97\u7edf\u8ba1\u5b66\u663e\u8457\u6539\u5584\u7684\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff08PFS\uff09\u3001\u66f4\u9ad8\u7684\u5ba2\u89c2\u7f13\u89e3\u7387\u548c\u53ef\u63a7\u7684\u5b89\u5168\u6027\/\u8010\u53d7\u6027\u7279\u5f81\u3002\u6700\u5e38\u89c1\u76843\u7ea7\u53ca\u4ee5\u4e0a\u6cbb\u7597\u4e2d\u51fa\u73b0\u7684\u4e0d\u826f\u4e8b\u4ef6\uff08TEAE\uff09\u4e3a\u4e2d\u6027\u7c92\u7ec6\u80de\u8ba1\u6570\u964d\u4f4e\u3001\u4e2d\u6027\u7c92\u7ec6\u80de\u51cf\u5c11\u75c7\u548c\u767d\u7ec6\u80de\u51cf\u5c11\u75c7\u3002\u7814\u7a76\u7ed3\u679c\u5168\u6587\u53d1\u8868\u5728<i><a href=\"https:\/\/jamanetwork.com\/journals\/jamaoncology\/fullarticle\/2777901\" target=\"_blank\" rel=\"nofollow noopener\">JAMA Oncology<\/a><\/i>\u3002<\/li>\n<li>RATIONALE 304\uff08<a href=\"https:\/\/clinicaltrials.gov\/study\/NCT03663205?term=NCT03663205&amp;rank=1\" target=\"_blank\" rel=\"nofollow noopener\">NCT03663205<\/a>\uff09\u662f\u4e00\u9879\u5f00\u653e\u6027\u3001\u968f\u673a\u30013\u671f\u8bd5\u9a8c\uff0c\u5171\u5165\u7ec4334\u4f8b\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u975e\u9cde\u72b6NSCLC\u60a3\u8005\u3002\u8be5\u7814\u7a76\u8fbe\u5230\u4e3b\u8981\u7ec8\u70b9\uff0c\u5373\u66ff\u96f7\u5229\u73e0\u5355\u6297\u8054\u5408\u5316\u7597\u4f5c\u4e3a\u4e00\u7ebf\u6cbb\u7597\u7684PFS\u76f8\u6bd4\u5316\u7597\u83b7\u5f97\u4e86\u7edf\u8ba1\u5b66\u4e0a\u7684\u663e\u8457\u6539\u5584\uff08HR 0.65 [95% CI\uff1a0.47-0.91]; P=0.0054\uff09\uff0c\u540c\u65f6\u7f13\u89e3\u7387\u66f4\u9ad8\uff0c\u4e14\u7f13\u89e3\u6301\u7eed\u65f6\u95f4\u66f4\u957f\u3002\u6700\u5e38\u89c1\u76843\u7ea7\u53ca\u4ee5\u4e0aTEAE\u4e0e\u5316\u7597\u76f8\u5173\uff0c\u5305\u62ec\u4e2d\u6027\u7c92\u7ec6\u80de\u51cf\u5c11\u75c7\u548c\u767d\u7ec6\u80de\u51cf\u5c11\u75c7\u3002\u7814\u7a76\u7ed3\u679c\u5168\u6587\u53d1\u8868\u5728<i><a href=\"https:\/\/www.jto.org\/article\/S1556-0864(21)02176-6\/fulltext\" target=\"_blank\" rel=\"nofollow noopener\">Journal of Thoracic Oncology<\/a><\/i>\u3002<\/li>\n<li>RATIONALE 303\uff08<a href=\"https:\/\/clinicaltrials.gov\/study\/NCT03358875?term=NCT03358875&amp;rank=1\" target=\"_blank\" rel=\"nofollow noopener\">NCT03358875<\/a>\uff09\u662f\u4e00\u9879\u6bd4\u8f83\u66ff\u96f7\u5229\u73e0\u5355\u6297\u4e0e\u591a\u897f\u4ed6\u8d5b\u7684\u5f00\u653e\u6027\u3001\u968f\u673a\u30013\u671f\u8bd5\u9a8c\uff0c\u5171\u5165\u7ec4805\u4f8b\u65e2\u5f80\u63a5\u53d7\u542b\u94c2\u5316\u7597\u540e\u51fa\u73b0\u75be\u75c5\u8fdb\u5c55\u7684\u665a\u671fNSCLC\u60a3\u8005\u3002\u672c\u7814\u7a76\u8fbe\u5230\u4e86\u4e3b\u8981\u7ec8\u70b9\uff0c\u5373\u5728\u610f\u5411\u6027\u6cbb\u7597\u4eba\u7fa4\u4e2d\uff0c\u65e0\u8bba\u60a3\u8005PD-L1\u8868\u8fbe\u6c34\u5e73\u5982\u4f55\uff0c\u66ff\u96f7\u5229\u73e0\u5355\u6297\u4f5c\u4e3a\u4e8c\u7ebf\u6216\u4e09\u7ebf\u6cbb\u7597\u7684\u603b\u751f\u5b58\u671f\uff08OS\uff09\u76f8\u6bd4\u591a\u897f\u4ed6\u8d5b\u5177\u6709\u7edf\u8ba1\u5b66\u548c\u4e34\u5e8a\u610f\u4e49\u4e0a\u7684\u6539\u5584\uff08HR\uff1a0.66 [95% CI\uff1a0.56-0.79]\uff1bP&lt;0.0001\uff09\u3002\u6700\u5e38\u89c1\u76843\u7ea7\u53ca\u4ee5\u4e0aTEAE\u4e3a\u611f\u67d3\u6027\u80ba\u708e\u3001\u8d2b\u8840\u548c\u547c\u5438\u56f0\u96be\u3002\u7814\u7a76\u7ed3\u679c\u5168\u6587\u53d1\u8868\u5728<i><a href=\"https:\/\/www.jto.org\/article\/S1556-0864(22)01803-2\/fulltext\" target=\"_blank\" rel=\"nofollow noopener\">Journal of Thoracic Oncology<\/a><\/i>\u3002<\/li>\n<\/ul>\n<p>\u76ee\u524d\uff0c\u767e\u6d4e\u795e\u5dde\u5df2\u542f\u52a8\u8d85\u8fc717\u9879\u66ff\u96f7\u5229\u73e0\u5355\u6297\u7684\u6f5c\u5728\u6ce8\u518c\u6027\u7814\u7a76\uff0c\u5176\u4e2d\uff0c11\u98793\u671f\u968f\u673a\u5bf9\u7167\u7814\u7a76\u548c4\u98792\u671f\u7814\u7a76\u5747\u83b7\u5f97\u79ef\u6781\u6570\u636e\u3002\u901a\u8fc7\u8fd9\u4e9b\u7814\u7a76\uff0c\u66ff\u96f7\u5229\u73e0\u5355\u6297\u5df2\u5c55\u73b0\u51fa\u5176\u6f5c\u529b\uff1a\u5728\u8bf8\u591a\u60c5\u51b5\u4e0b\uff0c\u65e0\u8bba\u60a3\u8005PD-L1\u8868\u8fbe\u6c34\u5e73\u5982\u4f55\uff0c\u5b83\u90fd\u53ef\u4ee5\u5728\u5e7f\u6cdb\u7624\u79cd\u7684\u5355\u836f\u6216\u8054\u5408\u7528\u836f\u6cbb\u7597\u4e2d\uff0c\u4e3a\u6570\u5341\u4e07\u60a3\u8005\u5e26\u6765\u5177\u6709\u4e34\u5e8a\u610f\u4e49\u7684\u751f\u5b58\u83b7\u76ca\u6539\u5584\u548c\u751f\u6d3b\u8d28\u91cf\u63d0\u5347\u3002\u8fc4\u4eca\u4e3a\u6b62\uff0c\u66ff\u96f7\u5229\u73e0\u5355\u6297\u5df2\u60e0\u53ca\u8d85\u8fc790\u4e07\u5168\u7403\u60a3\u8005\u3002<\/p>\n<p><b>\u5173\u4e8e<\/b><b>NSCLC<\/b><\/p>\n<p>\u80ba\u764c\u662f\u7b2c\u4e8c\u5927\u5e38\u89c1\u764c\u75c7\u7c7b\u578b\uff0c\u4e5f\u662f\u5168\u7403\u764c\u75c7\u76f8\u5173\u6b7b\u4ea1\u4e3b\u8981\u75c5\u56e0<sup>[1]<\/sup> \u3002\u80ba\u764c\u662f\u6b27\u6d32\u7b2c\u4e09\u5927\u5e38\u89c1\u764c\u75c7\uff1bNSCLC\u5360\u6240\u6709\u80ba\u764c\u768485-90%<sup>[2]<\/sup>\u30022020\u5e74\uff0c\u6b27\u6d32\u65b0\u8bca\u65ad\u80ba\u764c\u75c5\u4f8b\u6570\u4f30\u8ba1\u4e3a477,534\u4f8b<sup>[3]<\/sup>\u3002<\/p>\n<p><b>\u5173\u4e8e\u66ff\u96f7\u5229\u73e0\u5355\u6297<\/b><\/p>\n<p>\u66ff\u96f7\u5229\u73e0\u5355\u6297\uff08\u4e2d\u6587\u5546\u54c1\u540d\uff1a\u767e\u6cfd\u5b89<sup>&reg;<\/sup>\uff0c\u82f1\u6587\u5546\u54c1\u540d\uff1aTEVIMBRA<sup>&reg;<\/sup>\uff09\u662f\u4e00\u6b3e\u7ecf\u7279\u6b8a\u8bbe\u8ba1\u7684\u4eba\u6e90\u5316IgG4\u6297PD-1\u5355\u514b\u9686\u6297\u4f53\uff0c\u5bf9PD-1\u5177\u6709\u9ad8\u4eb2\u548c\u529b\u548c\u7ed3\u5408\u7279\u5f02\u6027\uff0c\u8bbe\u8ba1\u76ee\u7684\u65e8\u5728\u6700\u5927\u9650\u5ea6\u5730\u51cf\u5c11\u4e0e\u5de8\u566c\u7ec6\u80de\u4e2d\u7684Fc\u03b3\u53d7\u4f53\u7ed3\u5408\uff0c\u5e2e\u52a9\u4eba\u4f53\u514d\u75ab\u7ec6\u80de\u8bc6\u522b\u5e76\u6740\u4f24\u80bf\u7624\u7ec6\u80de\u3002<\/p>\n<p><b>\u5173\u4e8e\u767e\u6d4e\u795e\u5dde<\/b><\/p>\n<p>\u767e\u6d4e\u795e\u5dde\u662f\u4e00\u5bb6\u5168\u7403\u80bf\u7624\u521b\u65b0\u516c\u53f8\uff0c\u4e13\u6ce8\u4e8e\u4e3a\u5168\u4e16\u754c\u7684\u764c\u75c7\u60a3\u8005\u7814\u53d1\u521b\u65b0\u6297\u80bf\u7624\u836f\u7269\u3002\u901a\u8fc7\u5f3a\u5927\u7684\u81ea\u4e3b\u7814\u53d1\u80fd\u529b\u548c\u5916\u90e8\u6218\u7565\u5408\u4f5c\uff0c\u6211\u4eec\u4e0d\u65ad\u52a0\u901f\u5f00\u53d1\u591a\u5143\u3001\u521b\u65b0\u7684\u836f\u7269\u7ba1\u7ebf\u548c\u4ea7\u54c1\u7ec4\u5408\uff0c\u81f4\u529b\u4e8e\u4e3a\u5168\u7403\u66f4\u591a\u60a3\u8005\u5168\u9762\u63d0\u5347\u836f\u7269\u53ef\u53ca\u6027\u548c\u53ef\u8d1f\u62c5\u6027\u3002\u5728\u5168\u7403\u4e94\u5927\u6d32\uff0c\u6211\u4eec\u6709\u8d85\u8fc710,000\u4eba\u7684\u56e2\u961f\uff0c\u5e76\u5728\u4e2d\u56fd\u5317\u4eac\u3001\u7f8e\u56fd\u9ebb\u7701\u5251\u6865\u548c\u745e\u58eb\u5df4\u585e\u5c14\u8bbe\u7acb\u4e86\u4e3b\u8981\u529e\u4e8b\u5904\u3002\u5982\u9700\u4e86\u89e3\u66f4\u591a\u4fe1\u606f\uff0c\u8bf7\u8bbf\u95eewww.beigene.com.cn\u6216\u5173\u6ce8&quot;\u767e\u6d4e\u795e\u5dde&quot;\u5fae\u4fe1\u516c\u4f17\u53f7\u3002<\/p>\n<p><b>\u524d\u77bb\u6027\u58f0\u660e<\/b><\/p>\n<p>\u672c\u65b0\u95fb\u7a3f\u5305\u542b\u6839\u636e\u300a1995\u5e74\u79c1\u4eba\u8bc1\u5238\u8bc9\u8bbc\u6539\u9769\u6cd5\u6848\u300b\uff08Private Securities Litigation Reform Act of 1995\uff09\u4ee5\u53ca\u5176\u4ed6\u8054\u90a6\u8bc1\u5238\u6cd5\u5f8b\u4e2d\u5b9a\u4e49\u7684\u524d\u77bb\u6027\u58f0\u660e\uff0c\u5305\u62ec\u767e\u6d4e\u795e\u5dde\u5c65\u884c\u627f\u8bfa\u5c06\u66ff\u96f7\u5229\u73e0\u5355\u6297\u5e26\u7ed9\u5168\u7403\u66f4\u591a\u60a3\u8005\u7684\u80fd\u529b\uff1b\u66ff\u96f7\u5229\u73e0\u5355\u6297\u5728\u5e7f\u6cdb\u7624\u79cd\u7684\u5355\u836f\u6216\u8054\u5408\u7528\u836f\u6cbb\u7597\u4e2d\uff0c\u4e3a\u6570\u5341\u4e07\u60a3\u8005\u5e26\u6765\u5177\u6709\u4e34\u5e8a\u610f\u4e49\u7684\u751f\u5b58\u83b7\u76ca\u6539\u5584\u548c\u751f\u6d3b\u8d28\u91cf\u63d0\u5347\u7684\u6f5c\u529b\uff1b\u4ee5\u53ca\u5728&quot;\u5173\u4e8e\u767e\u6d4e\u795e\u5dde&quot;\u6807\u9898\u4e0b\u63d0\u53ca\u7684\u767e\u6d4e\u795e\u5dde\u8ba1\u5212\u3001\u627f\u8bfa\u3001\u613f\u671b\u548c\u76ee\u6807\u3002\u7531\u4e8e\u5404\u79cd\u91cd\u8981\u56e0\u7d20\u7684\u5f71\u54cd\uff0c\u5b9e\u9645\u7ed3\u679c\u53ef\u80fd\u4e0e\u524d\u77bb\u6027\u58f0\u660e\u4e2d\u7684\u7ed3\u679c\u5b58\u5728\u5b9e\u8d28\u6027\u5dee\u5f02\u3002\u8fd9\u4e9b\u56e0\u7d20\u5305\u62ec\uff1a\u767e\u6d4e\u795e\u5dde\u8bc1\u660e\u5176\u5019\u9009\u836f\u7269\u7684\u529f\u6548\u548c\u5b89\u5168\u6027\u7684\u80fd\u529b\uff1b\u5019\u9009\u836f\u7269\u7684\u4e34\u5e8a\u7ed3\u679c\u53ef\u80fd\u4e0d\u652f\u6301\u8fdb\u4e00\u6b65\u5f00\u53d1\u6216\u4e0a\u5e02\u5ba1\u6279\uff1b\u836f\u653f\u90e8\u95e8\u7684\u884c\u52a8\u53ef\u80fd\u4f1a\u5f71\u54cd\u5230\u4e34\u5e8a\u8bd5\u9a8c\u7684\u542f\u52a8\u3001\u65f6\u95f4\u8868\u548c\u8fdb\u5c55\u4ee5\u53ca\u836f\u7269\u4e0a\u5e02\u5ba1\u6279\uff1b\u767e\u6d4e\u795e\u5dde\u7684\u4e0a\u5e02\u836f\u7269\u53ca\u5019\u9009\u836f\u7269\uff08\u5982\u80fd\u83b7\u6279\uff09\u83b7\u5f97\u5546\u4e1a\u6210\u529f\u7684\u80fd\u529b\uff1b\u767e\u6d4e\u795e\u5dde\u83b7\u5f97\u548c\u7ef4\u62a4\u5bf9\u5176\u836f\u7269\u548c\u6280\u672f\u7684\u77e5\u8bc6\u4ea7\u6743\u4fdd\u62a4\u7684\u80fd\u529b\uff1b\u767e\u6d4e\u795e\u5dde\u4f9d\u8d56\u7b2c\u4e09\u65b9\u8fdb\u884c\u836f\u7269\u5f00\u53d1\u3001\u751f\u4ea7\u3001\u5546\u4e1a\u5316\u548c\u5176\u4ed6\u670d\u52a1\u7684\u60c5\u51b5\uff1b\u767e\u6d4e\u795e\u5dde\u53d6\u5f97\u76d1\u7ba1\u5ba1\u6279\u548c\u5546\u4e1a\u5316\u533b\u836f\u4ea7\u54c1\u7684\u6709\u9650\u7ecf\u9a8c\uff0c\u53ca\u5176\u83b7\u5f97\u8fdb\u4e00\u6b65\u7684\u8425\u8fd0\u8d44\u91d1\u4ee5\u5b8c\u6210\u5019\u9009\u836f\u7269\u5f00\u53d1\u53ca\u5b9e\u73b0\u5e76\u4fdd\u6301\u76c8\u5229\u7684\u80fd\u529b\uff1b\u4ee5\u53ca\u767e\u6d4e\u795e\u5dde\u5728\u6700\u8fd1\u5e74\u5ea6\u62a5\u544a\u7684 10-K \u8868\u683c\u4e2d&quot;\u98ce\u9669\u56e0\u7d20&quot;\u7ae0\u8282\u91cc\u66f4\u5168\u9762\u8ba8\u8bba\u7684\u5404\u7c7b\u98ce\u9669\uff1b\u4ee5\u53ca\u767e\u6d4e\u795e\u5dde\u5411\u7f8e\u56fd\u8bc1\u5238\u4ea4\u6613\u59d4\u5458\u4f1a\u671f\u540e\u5448\u62a5\u4e2d\u5173\u4e8e\u6f5c\u5728\u98ce\u9669\u3001\u4e0d\u786e\u5b9a\u6027\u4ee5\u53ca\u5176\u4ed6\u91cd\u8981\u56e0\u7d20\u7684\u8ba8\u8bba\u3002\u672c\u65b0\u95fb\u7a3f\u4e2d\u7684\u6240\u6709\u4fe1\u606f\u4ec5\u53ca\u4e8e\u65b0\u95fb\u7a3f\u53d1\u5e03\u4e4b\u65e5\uff0c\u9664\u975e\u6cd5\u5f8b\u8981\u6c42\uff0c\u767e\u6d4e\u795e\u5dde\u5e76\u65e0\u8d23\u4efb\u66f4\u65b0\u8be5\u7b49\u4fe1\u606f\u3002<\/p>\n<div>\n<table border=\"0\" cellspacing=\"0\" cellpadding=\"1\" class=\"prnbcc\">\n<tbody>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">[1] Globocan 2020. <a href=\"https:\/\/gco.iarc.fr\/today\/data\/factsheets\/populations\/900-world-fact-sheets.pdf\" target=\"_blank\" class=\"prnews_a\" rel=\"nofollow noopener\">900-world-fact-sheets.pdf (iarc.fr)<\/a>.<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">[2] European Society of Medical Oncology. What is Non-Small-Cell Lung Cancer? <a href=\"https:\/\/www.esmo.org\/content\/download\/7252\/143219\/file\/en-non-small-cell-lung-cancer-guide-for-patients.pdf\" target=\"_blank\" class=\"prnews_a\" rel=\"nofollow noopener\">https:\/\/www.esmo.org\/content\/download\/7252\/143219\/file\/en-non-small-cell-lung-cancer-guide-for-patients.pdf<\/a>.<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">[3] Sung H, et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2021;71(3):209-49.<\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table><\/div>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u5305\u542b\u4e09\u98793\u671f\u4e34\u5e8a\u8bd5\u9a8c\u7684\u7efc\u5408\u5f00\u53d1\u8ba1\u5212\u8bc1\u660e\u66ff\u96f7\u5229\u73e0\u5355\u6297\u4e3a\u521d\u6cbb\u548c\u590d\u53d1\u6027\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u60a3\u8005\u5e26\u6765\u83b7\u76ca \u6b64\u51b3\u5b9a\u662f\u66ff\u96f7\u5229\u73e0\u5355\u6297\u5728\u8be5\u5730\u533a\u83b7\u5f97\u7684\u7b2c\u4e8c\u9879\u6279\u51c6 \u4e2d\u56fd\u5317\u4eac\u3001\u7f8e\u56fd\u9ebb\u7701\u5251\u6865\u548c\u745e\u58eb\u5df4\u585e\u5c142024\u5e744\u670823\u65e5 \/\u7f8e\u901a\u793e\/ &#8212; \u767e\u6d4e\u795e\u5dde\uff08\u7eb3\u65af\u8fbe\u514b\u4ee3\u7801\uff1a BGNE\uff1b\u9999\u6e2f\u8054\u4ea4\u6240\u4ee3\u7801\uff1a06160\uff1b\u4e0a\u4ea4\u6240\u4ee3\u7801\uff1a688235\uff09\u662f\u4e00\u5bb6\u5168\u7403\u80bf\u7624\u521b\u65b0\u516c\u53f8\uff0c\u4eca\u65e5\u5ba3\u5e03\u6b27\u76df\u59d4\u5458\u4f1a\uff08EC\uff09\u5df2\u6279\u51c6\u66ff\u96f7\u5229\u73e0\u5355\u6297\u7528\u4e8e\u4e09\u9879\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff08NSCLC\uff09\u9002\u5e94\u75c7\u7684\u4e00\u7ebf\u53ca\u4e8c\u7ebf\u6cbb\u7597\u3002 \u767e\u6d4e\u795e\u5dde\u5b9e\u4f53\u80bf\u7624\u9996\u5e2d\u533b\u5b66\u5b98Mark Lanasa\u533b\u5b66\u535a\u58eb\u8868\u793a\uff1a&quot;\u66ff\u96f7\u5229\u73e0\u5355\u6297\u662f\u767e\u6d4e\u795e\u5dde\u5b9e\u4f53\u80bf\u7624\u4ea7\u54c1\u7ec4\u5408\u7684\u57fa\u7840\uff0c\u5e76\u5df2\u5728NSCLC\u7b49\u591a\u79cd\u80bf\u7624\u7c7b\u578b\u4e2d\u5c55\u73b0\u51fa\u6f5c\u529b\u3002\u5728NSCLC\u7684\u6240\u6709\u75be\u75c5\u9636\u6bb5\u5747\u6709\u8bb8\u591a\u5c1a\u672a\u88ab\u6ee1\u8db3\u7684\u9700\u6c42\u3002\u6b64\u6b21EC\u7684\u51b3\u5b9a\u6807\u5fd7\u7740\u66ff\u96f7\u5229\u73e0\u5355\u6297\u5728\u8be5\u5730\u533a\u83b7\u5f97\u7b2c\u4e8c\u9879\u6279\u51c6\uff0c\u5728\u6b27\u76df\u5730\u533a\uff0c\u66ff\u96f7\u5229\u73e0\u5355\u6297\u53ef\u7528\u4e8e\u6cbb\u7597NSCLC\u548c\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u98df\u7ba1\u9cde\u72b6\u7ec6\u80de\u764c\uff08ESCC\uff09\u3002\u5728\u51e0\u5468\u524d\uff0c\u7f8e\u56fd\u98df\u54c1\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08FDA\uff09\u6279\u51c6\u4e86\u66ff\u96f7\u5229\u73e0\u5355\u6297\u7528\u4e8eESCC\u7684\u4e8c\u7ebf\u6cbb\u7597\uff0c\u8fd9\u4f7f\u6211\u4eec\u80fd\u591f\u66f4\u597d\u5730\u5c65\u884c\u627f\u8bfa\uff0c\u5c06\u8fd9\u4e00\u521b\u65b0\u7597\u6cd5\u5e26\u7ed9\u5168\u4e16\u754c\u66f4\u591a\u60a3\u8005\u3002&quot; \u66ff\u96f7\u5229\u73e0\u5355\u6297\u672c\u6b21\u83b7\u6279\u9002\u5e94\u75c7\u4e3a\uff1a \u8054\u5408\u7d2b\u6749\u9187\u548c\u5361\u94c2\u6216\u6ce8\u5c04\u7528\u7d2b\u6749\u9187\uff08\u767d\u86cb\u767d\u7ed3\u5408\u578b\uff09\u548c\u5361\u94c2\u7528\u4e8e\u4e0d\u9002\u5408\u624b\u672f\u5207\u9664\u6216\u63a5\u53d7\u542b\u94c2\u653e\u5316\u7597\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u9cde\u72b6\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u6210\u4eba\u60a3\u8005\u7684\u4e00\u7ebf\u6cbb\u7597\uff1b \u8054\u5408\u57f9\u7f8e\u66f2\u585e\u548c\u94c2\u7c7b\u5316\u7597\u7528\u4e8ePD-L1\u8868\u8fbe\u226550%\u4e14\u65e0\u8868\u76ae\u751f\u957f\u56e0\u5b50\u53d7\u4f53\uff08EGFR\uff09\u6216\u95f4\u53d8\u6027\u6dcb\u5df4\u7624\u6fc0\u9176\uff08ALK\uff09\u9633\u6027\u7a81\u53d8\u3001\u4e0d\u9002\u5408\u624b\u672f\u5207\u9664\u6216\u63a5\u53d7\u542b\u94c2\u653e\u5316\u7597\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u975e\u9cde\u72b6\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u6210\u4eba\u60a3\u8005\u7684\u4e00\u7ebf\u6cbb\u7597\uff1b \u5355\u836f\u7528\u4e8e\u6cbb\u7597\u65e2\u5f80\u63a5\u53d7\u542b\u94c2\u836f\u7269\u6cbb\u7597\u540e\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027NSCLC\u6210\u4eba\u60a3\u8005\u3002EGFR\u7a81\u53d8\u6216ALK\u7a81\u53d8\u9633\u6027\u7684NSCLC\u60a3\u8005\u5728\u63a5\u53d7\u66ff\u96f7\u5229\u73e0\u5355\u6297\u6cbb\u7597\u524d\u5e94\u5f53\u5df2\u63a5\u53d7\u8fc7\u9776\u5411\u6cbb\u7597\u3002 \u897f\u73ed\u7259\u9a6c\u5fb7\u91ccHospital Universitario 12 de Octubre\u533b\u9662\u80bf\u7624\u5185\u79d1\u4e3b\u4efbLuis Paz-Ares \u533b\u5b66\u535a\u58eb\u8868\u793a\uff1a&quot;\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u4ecd\u7136\u662f\u6b27\u6d32\u6700\u5e38\u89c1\u548c\u81f4\u547d\u7684\u764c\u75c7\u4e4b\u4e00\uff0c\u6709\u4e00\u534a\u60a3\u8005\u5728\u786e\u8bca\u65f6\u5c31\u5df2\u7ecf\u8fdb\u5c55\u81f3\u665a\u671f\uff0c\u56e0\u6b64\u6cbb\u7597\u96be\u5ea6\u5f88\u5927\u3002\u5728\u8fd9\u4e09\u9879 3 \u671f\u7814\u7a76\u4e2d\uff0c\u66ff\u96f7\u5229\u73e0\u5355\u6297\u5df2\u8bc1\u660e\u53ef\u4ee5\u6539\u5584\u7279\u5b9a\u7c7b\u578bNSCLC\u60a3\u8005\u7684\u6cbb\u7597\u7ed3\u679c\uff0c\u4e3a\u60a3\u8005\u63d0\u4f9b\u4e86\u65b0\u7684\u9009\u62e9\u3002&quot; \u88ab\u6279\u51c6\u7528\u4e8e\u4e0a\u8ff0NSCLC\u9002\u5e94\u75c7\u7684\u66ff\u96f7\u5229\u73e0\u5355\u6297\u5546\u54c1\u540d\u4e3aTIZVENI&reg;\u3002\u767e\u6d4e\u795e\u5dde\u8ba1\u5212\u5c06NSCLC\u9002\u5e94\u75c7\u4e0eESCC\u4e8c\u7ebf\u6cbb\u7597\u9002\u5e94\u75c7\u7edf\u4e00\u5408\u5e76\u81f3\u5546\u54c1\u540dTEVIMBRA&reg;\u4e0b\uff0cTEVIMBRA&reg;\u5c06\u4e8e2024\u5e74\u665a\u4e9b\u65f6\u5019\u5728\u9996\u6279\u6b27\u76df\u56fd\u5bb6\u4e0a\u5e02\u3002TEVIMBRA&reg;\u5df2\u5728\u7f8e\u56fd\u548c\u6b27\u76df\u83b7\u6279\u7528\u4e8e\u6cbb\u7597\u65e2\u5f80\u63a5\u53d7\u5316\u7597\u7684\u665a\u671f\u6216\u8f6c\u79fb\u6027ESCC\u60a3\u8005\uff0c\u8be5\u836f\u54c1\u540c\u65f6\u8fd8\u5728\u63a5\u53d7\u6b27\u6d32\u836f\u54c1\u7ba1\u7406\u5c40\uff08EMA\uff09\u548cFDA\u5ba1\u8bc4\uff0c\u7528\u4e8e\u4e0d\u53ef\u5207\u9664\u3001\u590d\u53d1\u3001\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027ESCC\u60a3\u8005\u7684\u4e00\u7ebf\u6cbb\u7597\uff0c\u4ee5\u53ca\u80c3\u6216\u80c3\u98df\u7ba1\u7ed3\u5408\u90e8\u817a\u764c\u60a3\u8005\u7684\u4e00\u7ebf\u6cbb\u7597\u3002 EC\u672c\u6b21\u7684\u6279\u51c6\u57fa\u4e8e\u4e09\u98793 \u671fRATIONALE\u4e34\u5e8a\u7814\u7a76\u7ed3\u679c\uff0c\u8be5\u90e8\u5206\u7814\u7a76\u5171\u5165\u7ec41,499\u540d\u60a3\u8005\uff1a RATIONALE 307\uff08NCT03594747\uff09\u662f\u4e00\u9879\u5f00\u653e\u6027\u3001\u968f\u673a\u30013\u671f\u8bd5\u9a8c\uff0c\u5171\u5165\u7ec4360\u4f8b\u665a\u671f\u9cde\u72b6NSCLC\u60a3\u8005\u3002\u8be5\u7814\u7a76\u8fbe\u5230\u4e3b\u8981\u7ec8\u70b9\uff0c\u5373\u65e0\u8bbaPD-L1\u8868\u8fbe\u6c34\u5e73\u5982\u4f55\uff0c\u66ff\u96f7\u5229\u73e0\u5355\u6297\u8054\u5408\u5316\u7597\u4f5c\u4e3a\u4e00\u7ebf\u6cbb\u7597\u5747\u53ef\u83b7\u5f97\u7edf\u8ba1\u5b66\u663e\u8457\u6539\u5584\u7684\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff08PFS\uff09\u3001\u66f4\u9ad8\u7684\u5ba2\u89c2\u7f13\u89e3\u7387\u548c\u53ef\u63a7\u7684\u5b89\u5168\u6027\/\u8010\u53d7\u6027\u7279\u5f81\u3002\u6700\u5e38\u89c1\u76843\u7ea7\u53ca\u4ee5\u4e0a\u6cbb\u7597\u4e2d\u51fa\u73b0\u7684\u4e0d\u826f\u4e8b\u4ef6\uff08TEAE\uff09\u4e3a\u4e2d\u6027\u7c92\u7ec6\u80de\u8ba1\u6570\u964d\u4f4e\u3001\u4e2d\u6027\u7c92\u7ec6\u80de\u51cf\u5c11\u75c7\u548c\u767d\u7ec6\u80de\u51cf\u5c11\u75c7\u3002\u7814\u7a76\u7ed3\u679c\u5168\u6587\u53d1\u8868\u5728JAMA Oncology\u3002 RATIONALE 304\uff08NCT03663205\uff09\u662f\u4e00\u9879\u5f00\u653e\u6027\u3001\u968f\u673a\u30013\u671f\u8bd5\u9a8c\uff0c\u5171\u5165\u7ec4334\u4f8b\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u975e\u9cde\u72b6NSCLC\u60a3\u8005\u3002\u8be5\u7814\u7a76\u8fbe\u5230\u4e3b\u8981\u7ec8\u70b9\uff0c\u5373\u66ff\u96f7\u5229\u73e0\u5355\u6297\u8054\u5408\u5316\u7597\u4f5c\u4e3a\u4e00\u7ebf\u6cbb\u7597\u7684PFS\u76f8\u6bd4\u5316\u7597\u83b7\u5f97\u4e86\u7edf\u8ba1\u5b66\u4e0a\u7684\u663e\u8457\u6539\u5584\uff08HR 0.65 [95% CI\uff1a0.47-0.91]; P=0.0054\uff09\uff0c\u540c\u65f6\u7f13\u89e3\u7387\u66f4\u9ad8\uff0c\u4e14\u7f13\u89e3\u6301\u7eed\u65f6\u95f4\u66f4\u957f\u3002\u6700\u5e38\u89c1\u76843\u7ea7\u53ca\u4ee5\u4e0aTEAE\u4e0e\u5316\u7597\u76f8\u5173\uff0c\u5305\u62ec\u4e2d\u6027\u7c92\u7ec6\u80de\u51cf\u5c11\u75c7\u548c\u767d\u7ec6\u80de\u51cf\u5c11\u75c7\u3002\u7814\u7a76\u7ed3\u679c\u5168\u6587\u53d1\u8868\u5728Journal of Thoracic Oncology\u3002 RATIONALE 303\uff08NCT03358875\uff09\u662f\u4e00\u9879\u6bd4\u8f83\u66ff\u96f7\u5229\u73e0\u5355\u6297\u4e0e\u591a\u897f\u4ed6\u8d5b\u7684\u5f00\u653e\u6027\u3001\u968f\u673a\u30013\u671f\u8bd5\u9a8c\uff0c\u5171\u5165\u7ec4805\u4f8b\u65e2\u5f80\u63a5\u53d7\u542b\u94c2\u5316\u7597\u540e\u51fa\u73b0\u75be\u75c5\u8fdb\u5c55\u7684\u665a\u671fNSCLC\u60a3\u8005\u3002\u672c\u7814\u7a76\u8fbe\u5230\u4e86\u4e3b\u8981\u7ec8\u70b9\uff0c\u5373\u5728\u610f\u5411\u6027\u6cbb\u7597\u4eba\u7fa4\u4e2d\uff0c\u65e0\u8bba\u60a3\u8005PD-L1\u8868\u8fbe\u6c34\u5e73\u5982\u4f55\uff0c\u66ff\u96f7\u5229\u73e0\u5355\u6297\u4f5c\u4e3a\u4e8c\u7ebf\u6216\u4e09\u7ebf\u6cbb\u7597\u7684\u603b\u751f\u5b58\u671f\uff08OS\uff09\u76f8\u6bd4\u591a\u897f\u4ed6\u8d5b\u5177\u6709\u7edf\u8ba1\u5b66\u548c\u4e34\u5e8a\u610f\u4e49\u4e0a\u7684\u6539\u5584\uff08HR\uff1a0.66 [95% CI\uff1a0.56-0.79]\uff1bP&lt;0.0001\uff09\u3002\u6700\u5e38\u89c1\u76843\u7ea7\u53ca\u4ee5\u4e0aTEAE\u4e3a\u611f\u67d3\u6027\u80ba\u708e\u3001\u8d2b\u8840\u548c\u547c\u5438\u56f0\u96be\u3002\u7814\u7a76\u7ed3\u679c\u5168\u6587\u53d1\u8868\u5728Journal of Thoracic Oncology\u3002 \u76ee\u524d\uff0c\u767e\u6d4e\u795e\u5dde\u5df2\u542f\u52a8\u8d85\u8fc717\u9879\u66ff\u96f7\u5229\u73e0\u5355\u6297\u7684\u6f5c\u5728\u6ce8\u518c\u6027\u7814\u7a76\uff0c\u5176\u4e2d\uff0c11\u98793\u671f\u968f\u673a\u5bf9\u7167\u7814\u7a76\u548c4\u98792\u671f\u7814\u7a76\u5747\u83b7\u5f97\u79ef\u6781\u6570\u636e\u3002\u901a\u8fc7\u8fd9\u4e9b\u7814\u7a76\uff0c\u66ff\u96f7\u5229\u73e0\u5355\u6297\u5df2\u5c55\u73b0\u51fa\u5176\u6f5c\u529b\uff1a\u5728\u8bf8\u591a\u60c5\u51b5\u4e0b\uff0c\u65e0\u8bba\u60a3\u8005PD-L1\u8868\u8fbe\u6c34\u5e73\u5982\u4f55\uff0c\u5b83\u90fd\u53ef\u4ee5\u5728\u5e7f\u6cdb\u7624\u79cd\u7684\u5355\u836f\u6216\u8054\u5408\u7528\u836f\u6cbb\u7597\u4e2d\uff0c\u4e3a\u6570\u5341\u4e07\u60a3\u8005\u5e26\u6765\u5177\u6709\u4e34\u5e8a\u610f\u4e49\u7684\u751f\u5b58\u83b7\u76ca\u6539\u5584\u548c\u751f\u6d3b\u8d28\u91cf\u63d0\u5347\u3002\u8fc4\u4eca\u4e3a\u6b62\uff0c\u66ff\u96f7\u5229\u73e0\u5355\u6297\u5df2\u60e0\u53ca\u8d85\u8fc790\u4e07\u5168\u7403\u60a3\u8005\u3002 \u5173\u4e8eNSCLC \u80ba\u764c\u662f\u7b2c\u4e8c\u5927\u5e38\u89c1\u764c\u75c7\u7c7b\u578b\uff0c\u4e5f\u662f\u5168\u7403\u764c\u75c7\u76f8\u5173\u6b7b\u4ea1\u4e3b\u8981\u75c5\u56e0[1] \u3002\u80ba\u764c\u662f\u6b27\u6d32\u7b2c\u4e09\u5927\u5e38\u89c1\u764c\u75c7\uff1bNSCLC\u5360\u6240\u6709\u80ba\u764c\u768485-90%[2]\u30022020\u5e74\uff0c\u6b27\u6d32\u65b0\u8bca\u65ad\u80ba\u764c\u75c5\u4f8b\u6570\u4f30\u8ba1\u4e3a477,534\u4f8b[3]\u3002 \u5173\u4e8e\u66ff\u96f7\u5229\u73e0\u5355\u6297 \u66ff\u96f7\u5229\u73e0\u5355\u6297\uff08\u4e2d\u6587\u5546\u54c1\u540d\uff1a\u767e\u6cfd\u5b89&reg;\uff0c\u82f1\u6587\u5546\u54c1\u540d\uff1aTEVIMBRA&reg;\uff09\u662f\u4e00\u6b3e\u7ecf\u7279\u6b8a\u8bbe\u8ba1\u7684\u4eba\u6e90\u5316IgG4\u6297PD-1\u5355\u514b\u9686\u6297\u4f53\uff0c\u5bf9PD-1\u5177\u6709\u9ad8\u4eb2\u548c\u529b\u548c\u7ed3\u5408\u7279\u5f02\u6027\uff0c\u8bbe\u8ba1\u76ee\u7684\u65e8\u5728\u6700\u5927\u9650\u5ea6\u5730\u51cf\u5c11\u4e0e\u5de8\u566c\u7ec6\u80de\u4e2d\u7684Fc\u03b3\u53d7\u4f53\u7ed3\u5408\uff0c\u5e2e\u52a9\u4eba\u4f53\u514d\u75ab\u7ec6\u80de\u8bc6\u522b\u5e76\u6740\u4f24\u80bf\u7624\u7ec6\u80de\u3002 \u5173\u4e8e\u767e\u6d4e\u795e\u5dde \u767e\u6d4e\u795e\u5dde\u662f\u4e00\u5bb6\u5168\u7403\u80bf\u7624\u521b\u65b0\u516c\u53f8\uff0c\u4e13\u6ce8\u4e8e\u4e3a\u5168\u4e16\u754c\u7684\u764c\u75c7\u60a3\u8005\u7814\u53d1\u521b\u65b0\u6297\u80bf\u7624\u836f\u7269\u3002\u901a\u8fc7\u5f3a\u5927\u7684\u81ea\u4e3b\u7814\u53d1\u80fd\u529b\u548c\u5916\u90e8\u6218\u7565\u5408\u4f5c\uff0c\u6211\u4eec\u4e0d\u65ad\u52a0\u901f\u5f00\u53d1\u591a\u5143\u3001\u521b\u65b0\u7684\u836f\u7269\u7ba1\u7ebf\u548c\u4ea7\u54c1\u7ec4\u5408\uff0c\u81f4\u529b\u4e8e\u4e3a\u5168\u7403\u66f4\u591a\u60a3\u8005\u5168\u9762\u63d0\u5347\u836f\u7269\u53ef\u53ca\u6027\u548c\u53ef\u8d1f\u62c5\u6027\u3002\u5728\u5168\u7403\u4e94\u5927\u6d32\uff0c\u6211\u4eec\u6709\u8d85\u8fc710,000\u4eba\u7684\u56e2\u961f\uff0c\u5e76\u5728\u4e2d\u56fd\u5317\u4eac\u3001\u7f8e\u56fd\u9ebb\u7701\u5251\u6865\u548c\u745e\u58eb\u5df4\u585e\u5c14\u8bbe\u7acb\u4e86\u4e3b\u8981\u529e\u4e8b\u5904\u3002\u5982\u9700\u4e86\u89e3\u66f4\u591a\u4fe1\u606f\uff0c\u8bf7\u8bbf\u95eewww.beigene.com.cn\u6216\u5173\u6ce8&quot;\u767e\u6d4e\u795e\u5dde&quot;\u5fae\u4fe1\u516c\u4f17\u53f7\u3002 \u524d\u77bb\u6027\u58f0\u660e \u672c\u65b0\u95fb\u7a3f\u5305\u542b\u6839\u636e\u300a1995\u5e74\u79c1\u4eba\u8bc1\u5238\u8bc9\u8bbc\u6539\u9769\u6cd5\u6848\u300b\uff08Private Securities&hellip; <a class=\"read-more\" href=\"https:\/\/www.xinwengao.com\/cn\/pr\/20240423170500111966\">Read More<\/a><\/p>\n","protected":false},"author":556,"featured_media":0,"comment_status":"close","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1965],"tags":[],"class_list":["post-111966","post","type-post","status-publish","format-standard","hentry","category-partnerships"],"amp_enabled":true,"_links":{"self":[{"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/posts\/111966","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/users\/556"}],"replies":[{"embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/comments?post=111966"}],"version-history":[{"count":1,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/posts\/111966\/revisions"}],"predecessor-version":[{"id":111967,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/posts\/111966\/revisions\/111967"}],"wp:attachment":[{"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/media?parent=111966"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/categories?post=111966"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/tags?post=111966"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}