{"id":111806,"date":"2024-04-23T09:07:00","date_gmt":"2024-04-23T02:07:00","guid":{"rendered":"https:\/\/www.xinwengao.com\/cn\/pr\/20240423090700111806"},"modified":"2024-04-24T11:59:17","modified_gmt":"2024-04-24T03:59:17","slug":"%e5%8b%83%e6%9e%97%e6%a0%bc%e6%ae%b7%e6%a0%bc%e7%bf%b0%e6%90%ba%e6%89%8b%e8%b5%ad%e7%9f%b3%e7%94%9f%e5%8c%bb%ef%bc%8c%e5%bc%80%e5%8f%91%e6%99%9a%e6%9c%9f%e8%82%9d%e7%97%85%e6%96%b0%e5%9e%8b%e5%86%8d","status":"publish","type":"post","link":"https:\/\/www.xinwengao.com\/cn\/pr\/20240423090700111806","title":{"rendered":"\u52c3\u6797\u683c\u6bb7\u683c\u7ff0\u643a\u624b\u8d6d\u77f3\u751f\u533b\uff0c\u5f00\u53d1\u665a\u671f\u809d\u75c5\u65b0\u578b\u518d\u751f\u7597\u6cd5"},"content":{"rendered":"<ul type=\"disc\">\n<li><b>\u6b64\u5408\u4f5c\u51f8\u663e\u4e86\u8d6d\u77f3\u751f\u533b\u72ec\u7279\u4e14\u4ee5\u4eba\u4e3a\u6838\u5fc3\u7684\u836f\u7269\u53d1\u73b0\u6280\u672f\uff0c\u5e76\u7ed3\u5408\u5176\u6df1\u5ea6\u57fa\u56e0\u7ec4\u8868\u73b0\u578b\u5206\u6790\u3001<\/b><b>RNA<\/b><b>\u5408\u6210\u548c\u4eba\u4f53\u5668\u5b98\u704c\u6ce8\u6a21\u578b\uff0c\u9488\u5bf9\u672a\u6709\u5b8c\u5584\u6cbb\u7597\u65b9\u6cd5\u7684\u809d\u75c5\uff0c\u52a0\u901f\u5f00\u53d1\u521b\u65b0\u6cbb\u7597\u9776\u70b9\u3002<\/b><\/li>\n<li><b>\u5728\u8fd9\u9879\u591a\u5e74\u671f\u5408\u4f5c\u9879\u76ee\u4e2d\uff0c\u4e24\u5bb6\u516c\u53f8\u5c06\u8054\u624b\u7814\u7a76\u591a\u4e2a\u6cbb\u7597\u9776\u70b9\u3002<\/b><\/li>\n<\/ul>\n<p><p>\u82f1\u56fd\u725b\u6d252024\u5e744\u670823\u65e5 \/\u7f8e\u901a\u793e\/ &#8212; 4\u670822\u65e5\uff0c\u52c3\u6797\u683c\u6bb7\u683c\u7ff0\u5ba3\u5e03\u4e0e\u8d6d\u77f3\u751f\u533b\uff08Ochre Bio \uff09\u5efa\u7acb\u5408\u4f5c\u4f19\u4f34\u5173\u7cfb\uff0c\u5c06\u5171\u540c\u4e13\u6ce8\u4e8e\u53d1\u73b0\u548c\u5f00\u53d1\u9488\u5bf9\u6162\u6027\u809d\u75c5\uff08CLDs\uff09\uff08\u5982\u4ee3\u8c22\u529f\u80fd\u969c\u788d\u76f8\u5173\u8102\u80aa\u6027\u809d\u708e\uff08MASH\uff09\uff09\u7684\u65b0\u578b\u540c\u7c7b\u9996\u521b\u518d\u751f\u7597\u6cd5\u3002<\/p>\n<p>\u4f5c\u4e3a\u6162\u6027\u809d\u75c5\u836f\u7269\u5f00\u53d1\u9886\u57df\u7684\u5148\u9a71\u8005\uff0c\u8d6d\u77f3\u751f\u533b\u5c06\u5229\u7528\u5176\u4e13\u5229\u836f\u7269\u53d1\u73b0\u5e73\u53f0\uff0c\u5c06\u673a\u5668\u5b66\u4e60\u4e0e\u4eba\u7c7b\u5927\u6570\u636e\u76f8\u7ed3\u5408\uff0c\u52a0\u4e0a\u5148\u8fdb\u7684\u6210\u50cf\u548c\u6df1\u5ea6\u57fa\u56e0\u7ec4\u8868\u73b0\u578b\u5206\u6790\u3001\u81ea\u6709\u7684RNA\u5316\u5b66\u7814\u7a76\u4ee5\u53ca\u5e94\u7528\u4e13\u5229\u7684\u4f53\u5916\u4eba\u4f53\u5668\u5b98\u704c\u6ce8\u6a21\u578b\u7684\u72ec\u5bb6\u6280\u672f\uff0c\u53ef\u4fc3\u8fdb\u5bf9\u591a\u4e2a\u6cbb\u7597\u6162\u6027\u809d\u75c5\u7684\u521b\u65b0\u518d\u751f\u9776\u70b9\u7684\u9274\u5b9a\u3001\u8868\u5f81\u5206\u6790\u548c\u9a8c\u8bc1\u3002<\/p>\n<p>\u6b64\u6b21\u5408\u4f5c\u662f\u52c3\u6797\u683c\u6bb7\u683c\u7ff0\u81f4\u529b\u4e8e\u6539\u5584\u60a3\u6709\u76f8\u4e92\u5173\u8054\u7684\u5fc3\u8840\u7ba1\u3001\u80be\u810f\u548c\u4ee3\u8c22\u75be\u75c5\uff08CRM\uff09\uff08\u5305\u62ec&nbsp;MASH \u809d\u786c\u5316\uff09\u60a3\u8005\u751f\u6d3b\u627f\u8bfa\u7684\u4e00\u90e8\u5206\u3002\u5408\u4f5c\u8ba1\u5212\u4e3b\u8981\u5229\u7528\u8d6d\u77f3\u751f\u533b\u7684\u72ec\u7279\u4eba\u7c7b\u6570\u636e\u5e93\u548c\u75be\u75c5\u6a21\u578b\uff0c\u4ee5\u52a0\u901f\u5f00\u53d1\u548c\u9a8c\u8bc1\u65b0\u578b\u809d\u75c5\u9776\u70b9\u3002<\/p>\n<p>\u968f\u7740\u6162\u6027\u809d\u75c5\u75c5\u7a0b\u9010\u6e10\u6076\u5316\uff0c\u809d\u810f\u7684\u81ea\u7136\u518d\u751f\u4e0e\u4fee\u590d\u80fd\u529b\u4f1a\u51cf\u5f31\uff0c\u8fdb\u800c\u5bfc\u81f4\u809d\u8870\u7aed\u6216\u809d\u764c\u7b49\u4e25\u91cd\u5e76\u53d1\u75c7<sup>[1]<\/sup>\u3002\u636e\u7edf\u8ba1\uff0c\u5168\u7403\u6bcf\u5e74\u7ea6\u6709 100 \u4e07\u4eba\u6b7b\u4e8e\u6162\u6027\u809d\u75c5\u548c\u76f8\u5173\u7684\u809d\u786c\u5316<sup>[2]<\/sup>\u3002\u6b64\u5916\uff0c\u6162\u6027\u809d\u75c5\u8fd8\u4f1a\u9020\u6210\u4e25\u91cd\u7684\u5e76\u53d1\u75c7\uff0c\u9020\u6210\u5065\u5eb7\u76f8\u5173\u751f\u6d3b\u8d28\u91cf\uff08HRQL\uff09\u7684\u964d\u4f4e\u548c\u6c89\u91cd\u7684\u7ecf\u6d4e\u8d1f\u62c5<sup>[3]<\/sup>\u3002\u7531\u4e8e\u76ee\u524d\u6ca1\u6709\u83b7\u6279\u7528\u4e8e\u6cbb\u7597\u6162\u6027\u809d\u75c5\u5f15\u8d77\u7684\u809d\u786c\u5316\u7684\u836f\u7269\uff0c\u56e0\u6b64\u8feb\u5207\u9700\u8981\u521b\u65b0\u6709\u6548\u7684\u7597\u6cd5\u3002<\/p>\n<p>\u52c3\u6797\u683c\u6bb7\u683c\u7ff0\u9ad8\u7ea7\u526f\u603b\u88c1\u3001\u5fc3\u8840\u7ba1\u4ee3\u8c22\u75be\u75c5\u7814\u7a76\u5168\u7403\u8d1f\u8d23\u4ebaS&oslash;ren Tullin\u535a\u58eb\u8868\u793a\uff1a\u201c\u6211\u4eec\u4e0e\u8d6d\u77f3\u751f\u533b\u7684\u5408\u4f5c\u6e90\u4e8e\u4e00\u4e2a\u5171\u540c\u76ee\u6807\uff0c\u671f\u671b\u52a0\u901f\u5f00\u53d1\u9488\u5bf9\u5305\u62ecMASH\u809d\u786c\u5316\u5728\u5185\u7684\u6162\u6027\u809d\u75c5\u7684\u521b\u65b0\u7597\u6cd5\u3002\u8d6d\u77f3\u751f\u533b\u5728\u809d\u75c5\u7814\u7a76\u9886\u57df\u5177\u5907\u72ec\u7279\u5f3a\u5927\u7684\u5b9e\u529b\uff0c\u51ed\u501f\u4ed6\u4eec\u5728\u57fa\u56e0\u7ec4\u5b66\u548c\u673a\u5668\u5b66\u4e60\u65b9\u9762\u7684\u5148\u8fdb\u6280\u672f\uff0c\u642d\u914d\u5176\u4ee5\u4eba\u4e3a\u6838\u5fc3\u7684\u8f6c\u8bd1\u6a21\u578b\uff0c\u5c06\u6709\u671b\u53d1\u73b0\u65b0\u7684\u518d\u751f\u9014\u5f84\uff0c\u4e3a\u6162\u6027\u809d\u75c5\u60a3\u8005\u7684\u751f\u6d3b\u8d28\u91cf\u5e26\u6765\u5b9e\u9645\u7684\u6539\u53d8\u3002\u201d<\/p>\n<p>\u8d6d\u77f3\u751f\u533b\u8054\u5408\u521b\u59cb\u4eba\u517c\u9996\u5e2d\u79d1\u5b66\u5b98Quin Wills\u8868\u793a\uff1a\u201c\u5728\u5168\u7403\u8303\u56f4\u5185\uff0c\u6162\u6027\u809d\u75c5\u662f\u4e00\u79cd\u5448\u4e0a\u5347\u8d8b\u52bf\u7684\u81f4\u6b7b\u75be\u75c5\uff0c\u6709\u7740\u5de8\u5927\u672a\u6ee1\u8db3\u7684\u60a3\u8005\u9700\u6c42\u3002\u6211\u4eec\u5f88\u9ad8\u5174\u80fd\u4e0e\u52c3\u6797\u683c\u6bb7\u683c\u7ff0\u7684\u6770\u51fa\u79d1\u5b66\u5bb6\u56e2\u961f\u5408\u4f5c\uff0c\u6211\u4eec\u90fd\u76f8\u4fe1\u809d\u810f\u518d\u751f\u5bf9\u4e8e\u809d\u8870\u7aed\u60a3\u8005\u6765\u8bf4\uff0c\u662f\u4e00\u4e2a\u5c1a\u672a\u5145\u5206\u63a2\u7d22\u7684\u6cbb\u7597\u76ee\u6807\u3002\u201d<\/p>\n<p>\u5728\u8fd9\u9879\u591a\u5e74\u671f\u3001\u591a\u9776\u70b9\u7684\u5408\u4f5c\u5f00\u53d1\u9879\u76ee\u4e2d\uff0c\u8d6d\u77f3\u751f\u533b\u5c06\u83b7\u5f97\u9ad8\u8fbe&nbsp;3500 \u4e07\u7f8e\u5143\u7684\u9884\u4ed8\u6b3e\u548c\u8fd1\u671f\u7814\u7a76\u7684\u91cc\u7a0b\u7891\u6b3e\u9879\u3002\u8d6d\u77f3\u751f\u533b\u8fd8\u6709\u6743\u83b7\u5f97\u57fa\u4e8e\u4e34\u5e8a\u7814\u7a76\u3001\u836f\u7269\u6ce8\u518c\u548c\u5546\u4e1a\u5316\u6210\u529f\u7684\u91cc\u7a0b\u7891\u4ed8\u6b3e\u4ee5\u53ca\u4e0a\u5e02\u4ea7\u54c1\u7684\u9636\u68af\u5f0f\u9500\u552e\u63d0\u6210\uff0c\u603b\u4ea4\u6613\u91d1\u989d\u9884\u8ba1\u8d85\u8fc7&nbsp;10 \u4ebf\u7f8e\u5143\u3002<\/p>\n<p>\u53c2\u8003\u6587\u732e<\/p>\n<p>1.&nbsp; Hora S, Wuestefeld T. Liver Injury and Regeneration: Current Understanding, New Approaches, and Future Perspectives. Cells. 2023 Sep; 12(17): 2129. doi: 10.3390\/cells12172129.<br \/>2.&nbsp; Wu, XN., Xue, F., Zhang, N. <i>et al<\/i>. Global burden of liver cirrhosis and other chronic liver diseases caused by specific etiologies from 1990 to 2019. BMC Public Health 24, 363 (2024). <a href=\"https:\/\/doi.org\/10.1186\/s12889-024-17948-6\" target=\"_blank\" rel=\"nofollow noopener\">https:\/\/doi.org\/10.1186\/s12889-024-17948-6<\/a>.<br \/>3.&nbsp; Younossi ZM et al. The Global Burden of Liver Disease. 2023. 21(8);1978-1991. doi.org\/10.1016\/j.cgh.2023.04.015.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u6b64\u5408\u4f5c\u51f8\u663e\u4e86\u8d6d\u77f3\u751f\u533b\u72ec\u7279\u4e14\u4ee5\u4eba\u4e3a\u6838\u5fc3\u7684\u836f\u7269\u53d1\u73b0\u6280\u672f\uff0c\u5e76\u7ed3\u5408\u5176\u6df1\u5ea6\u57fa\u56e0\u7ec4\u8868\u73b0\u578b\u5206\u6790\u3001RNA\u5408\u6210\u548c\u4eba\u4f53\u5668\u5b98\u704c\u6ce8\u6a21\u578b\uff0c\u9488\u5bf9\u672a\u6709\u5b8c\u5584\u6cbb\u7597\u65b9\u6cd5\u7684\u809d\u75c5\uff0c\u52a0\u901f\u5f00\u53d1\u521b\u65b0\u6cbb\u7597\u9776\u70b9\u3002 \u5728\u8fd9\u9879\u591a\u5e74\u671f\u5408\u4f5c\u9879\u76ee\u4e2d\uff0c\u4e24\u5bb6\u516c\u53f8\u5c06\u8054\u624b\u7814\u7a76\u591a\u4e2a\u6cbb\u7597\u9776\u70b9\u3002 \u82f1\u56fd\u725b\u6d252024\u5e744\u670823\u65e5 \/\u7f8e\u901a\u793e\/ &#8212; 4\u670822\u65e5\uff0c\u52c3\u6797\u683c\u6bb7\u683c\u7ff0\u5ba3\u5e03\u4e0e\u8d6d\u77f3\u751f\u533b\uff08Ochre Bio 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\u6b64\u6b21\u5408\u4f5c\u662f\u52c3\u6797\u683c\u6bb7\u683c\u7ff0\u81f4\u529b\u4e8e\u6539\u5584\u60a3\u6709\u76f8\u4e92\u5173\u8054\u7684\u5fc3\u8840\u7ba1\u3001\u80be\u810f\u548c\u4ee3\u8c22\u75be\u75c5\uff08CRM\uff09\uff08\u5305\u62ec&nbsp;MASH \u809d\u786c\u5316\uff09\u60a3\u8005\u751f\u6d3b\u627f\u8bfa\u7684\u4e00\u90e8\u5206\u3002\u5408\u4f5c\u8ba1\u5212\u4e3b\u8981\u5229\u7528\u8d6d\u77f3\u751f\u533b\u7684\u72ec\u7279\u4eba\u7c7b\u6570\u636e\u5e93\u548c\u75be\u75c5\u6a21\u578b\uff0c\u4ee5\u52a0\u901f\u5f00\u53d1\u548c\u9a8c\u8bc1\u65b0\u578b\u809d\u75c5\u9776\u70b9\u3002 \u968f\u7740\u6162\u6027\u809d\u75c5\u75c5\u7a0b\u9010\u6e10\u6076\u5316\uff0c\u809d\u810f\u7684\u81ea\u7136\u518d\u751f\u4e0e\u4fee\u590d\u80fd\u529b\u4f1a\u51cf\u5f31\uff0c\u8fdb\u800c\u5bfc\u81f4\u809d\u8870\u7aed\u6216\u809d\u764c\u7b49\u4e25\u91cd\u5e76\u53d1\u75c7[1]\u3002\u636e\u7edf\u8ba1\uff0c\u5168\u7403\u6bcf\u5e74\u7ea6\u6709 100 \u4e07\u4eba\u6b7b\u4e8e\u6162\u6027\u809d\u75c5\u548c\u76f8\u5173\u7684\u809d\u786c\u5316[2]\u3002\u6b64\u5916\uff0c\u6162\u6027\u809d\u75c5\u8fd8\u4f1a\u9020\u6210\u4e25\u91cd\u7684\u5e76\u53d1\u75c7\uff0c\u9020\u6210\u5065\u5eb7\u76f8\u5173\u751f\u6d3b\u8d28\u91cf\uff08HRQL\uff09\u7684\u964d\u4f4e\u548c\u6c89\u91cd\u7684\u7ecf\u6d4e\u8d1f\u62c5[3]\u3002\u7531\u4e8e\u76ee\u524d\u6ca1\u6709\u83b7\u6279\u7528\u4e8e\u6cbb\u7597\u6162\u6027\u809d\u75c5\u5f15\u8d77\u7684\u809d\u786c\u5316\u7684\u836f\u7269\uff0c\u56e0\u6b64\u8feb\u5207\u9700\u8981\u521b\u65b0\u6709\u6548\u7684\u7597\u6cd5\u3002 \u52c3\u6797\u683c\u6bb7\u683c\u7ff0\u9ad8\u7ea7\u526f\u603b\u88c1\u3001\u5fc3\u8840\u7ba1\u4ee3\u8c22\u75be\u75c5\u7814\u7a76\u5168\u7403\u8d1f\u8d23\u4ebaS&oslash;ren 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\u4e07\u7f8e\u5143\u7684\u9884\u4ed8\u6b3e\u548c\u8fd1\u671f\u7814\u7a76\u7684\u91cc\u7a0b\u7891\u6b3e\u9879\u3002\u8d6d\u77f3\u751f\u533b\u8fd8\u6709\u6743\u83b7\u5f97\u57fa\u4e8e\u4e34\u5e8a\u7814\u7a76\u3001\u836f\u7269\u6ce8\u518c\u548c\u5546\u4e1a\u5316\u6210\u529f\u7684\u91cc\u7a0b\u7891\u4ed8\u6b3e\u4ee5\u53ca\u4e0a\u5e02\u4ea7\u54c1\u7684\u9636\u68af\u5f0f\u9500\u552e\u63d0\u6210\uff0c\u603b\u4ea4\u6613\u91d1\u989d\u9884\u8ba1\u8d85\u8fc7&nbsp;10 \u4ebf\u7f8e\u5143\u3002 \u53c2\u8003\u6587\u732e 1.&nbsp; Hora S, Wuestefeld T. Liver Injury and Regeneration: Current Understanding, New Approaches, and Future Perspectives. Cells. 2023 Sep; 12(17): 2129. doi: 10.3390\/cells12172129.2.&nbsp; Wu, XN., Xue, F., Zhang, N. et al. Global burden&hellip; <a class=\"read-more\" href=\"https:\/\/www.xinwengao.com\/cn\/pr\/20240423090700111806\">Read More<\/a><\/p>\n","protected":false},"author":556,"featured_media":0,"comment_status":"close","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1965],"tags":[],"class_list":["post-111806","post","type-post","status-publish","format-standard","hentry","category-partnerships"],"amp_enabled":true,"_links":{"self":[{"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/posts\/111806","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/users\/556"}],"replies":[{"embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/comments?post=111806"}],"version-history":[{"count":1,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/posts\/111806\/revisions"}],"predecessor-version":[{"id":111807,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/posts\/111806\/revisions\/111807"}],"wp:attachment":[{"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/media?parent=111806"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/categories?post=111806"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/tags?post=111806"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}