{"id":110520,"date":"2024-04-10T17:51:00","date_gmt":"2024-04-10T10:51:00","guid":{"rendered":"https:\/\/www.xinwengao.com\/cn\/pr\/20240410175100110520"},"modified":"2024-04-11T00:44:39","modified_gmt":"2024-04-10T16:44:39","slug":"destiny-lung05-ii%e6%9c%9f%e4%b8%b4%e5%ba%8a%e7%a0%94%e7%a9%b6%e8%af%81%e5%ae%9e%e4%bc%98%e8%b5%ab%e5%be%97%e5%9c%a8%e6%97%a2%e5%be%80%e7%bb%8f%e6%b2%bb%e7%9a%84%e4%b8%ad%e5%9b%bdher2%e7%aa%81","status":"publish","type":"post","link":"https:\/\/www.xinwengao.com\/cn\/pr\/20240410175100110520","title":{"rendered":"DESTINY-Lung05 II\u671f\u4e34\u5e8a\u7814\u7a76\u8bc1\u5b9e\u4f18\u8d6b\u5f97\u00ae\u5728\u65e2\u5f80\u7ecf\u6cbb\u7684\u4e2d\u56fdHER2\u7a81\u53d8\u665a\u671f\u80ba\u764c\u60a3\u8005\u4e2d\u5177\u6709\u663e\u8457\u751f\u5b58\u83b7\u76ca"},"content":{"rendered":"

DESTINY-Lung05 II<\/i>\u671f\u4e34\u5e8a\u7814\u7a76\u7684\u5206\u6790\u7ed3\u679c\u663e\u793a\uff0c\u4f18\u8d6b\u5f97<\/i>®<\/sup><\/i>5.4mg\/kg<\/i>\u5242\u91cf\u65b9\u6848\u7684\u5ba2\u89c2\u7f13\u89e3\u7387\u4e3a<\/i>58.3%<\/i>\uff1b\u7ecf\u7814\u7a76\u8005\u8bc4\u4f30\u7684<\/i>PFS<\/i>\u4e3a<\/i>10.8<\/i>\u4e2a\u6708\u3002\u53ef\u63a7\u7684\u5b89\u5168\u6027\u8bc1\u5b9e\u4e86<\/i>5.4mg\/kg<\/i>\u662f\u6cbb\u7597\u65e2\u5f80\u63a5\u53d7\u8fc7\u6cbb\u7597\u7684<\/i>HER2<\/i>\u7a81\u53d8\u665a\u671f\u80ba\u764c\u60a3\u8005\u7684\u6700\u4f73\u5242\u91cf\u3002<\/i><\/p>\n

\u4e0a\u6d77<\/span>2024\u5e744\u670810\u65e5<\/span> \/\u7f8e\u901a\u793e\/ — \u57284\u67085\u65e5-4\u670810\u65e5\u4e3e\u529e\u7684\u7b2c115\u5c4a\u7f8e\u56fd\u764c\u75c7\u7814\u7a76\u534f\u4f1a\uff08AACR\uff09\u5e74\u4f1a\u671f\u95f4\uff0c\u7531\u963f\u65af\u5229\u5eb7\u548c\u7b2c\u4e00\u4e09\u5171\u5171\u540c\u5f00\u53d1\u7684\u4f18\u8d6b\u5f97®<\/sup>\uff08\u901a\u7528\u540d\uff1a\u5fb7\u66f2\u59a5\u73e0\u5355\u6297T-Dxd,DS-8201\uff09\u6cbb\u7597\u7ecf\u6cbb\u7684\u4e0d\u53ef\u5207\u9664\u548c\/\u6216\u8f6c\u79fb\u6027\u975e\u9cde\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u60a3\u8005\u7684II\u671fDESTINY-Lung05\u4e34\u5e8a\u8bd5\u9a8c\u6570\u636e\uff08\u6458\u8981\u53f7\uff1aCT248\/7\uff09\u9996\u6b21\u516c\u5e03\u3002\u7ed3\u679c\u663e\u793a\uff0c\u7ecf\u72ec\u7acb\u4e2d\u592e\u5ba1\u67e5\uff08ICR\uff09\u8bc4\u4f30\uff0c\u4e3b\u8981\u7814\u7a76\u7ec8\u70b9\u2014\u2014\u5ba2\u89c2\u7f13\u89e3\u7387\uff08ORR\uff09\u8fbe\u523058.3%\uff0895% CI\uff1a46.1- 69.8\uff09\uff1b\u5fb7\u66f2\u59a5\u73e0\u5355\u62975.4mg\/kg\u5728\u4e2d\u56fdHER2m\u8f6c\u79fb\u6027\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u60a3\u8005\u4e2d\u663e\u793a\u51fa\u6709\u4e34\u5e8a\u610f\u4e49\u7684\u3001\u6301\u4e45\u7684\u7597\u6548\u548c\u53ef\u63a7\u7684\u5b89\u5168\u6027\u3002\u7ed3\u679c\u4e0eDESTINY-Lung02\u548c\u5df2\u77e5\u7684\u5b89\u5168\u6027\u4e00\u81f4\uff0c\u652f\u6301\u5176\u5728\u4e2d\u56fd\u4eba\u7fa4\u4e2d\u7684\u5e94\u7528\u3002<\/p>\n

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\u5fb7\u66f2\u59a5\u73e0\u5355\u6297\u662f\u4e00\u79cd\u9776\u5411HER2\u7684\u65b0\u578b\u6297\u4f53\u5076\u8054\uff08ADC\uff09\u836f\u7269\uff0c\u5728DESTINY-Lung02 II\u671f\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\uff0c\u8d85\u8fc760%\u7684\u60a3\u8005\u4e3a\u4e9a\u6d32\u4eba\u7fa4\uff085.4\u548c6.4 mg\/kg\u7ec4\u5206\u522b\u670961.8%\u548c60.0%\u7684\u4e9a\u6d32\u60a3\u8005\u5165\u7ec4\uff09\uff0c\u7ed3\u679c\u663e\u793a\u4e9a\u6d32\u4eba\u7fa4\u4e0e\u603b\u4eba\u7fa4\u5177\u6709\u4e00\u81f4\u83b7\u76ca\u8d8b\u52bf\uff0c\u8be5\u7814\u7a76\u7ed3\u679c\u8fdb\u4e00\u6b65\u592f\u5b9e\u4e86\u5fb7\u66f2\u59a5\u73e0\u5355\u6297\u5728HER2\u7a81\u53d8\u665a\u671fNSCLC\u4e2d\u7684\u6807\u51c6\u6cbb\u7597\u5730\u4f4d[5]<\/sup>\u3002\u57fa\u4e8eDESTINY-Lung02\u7684\u9633\u6027\u7ed3\u679c\uff0c\u5fb7\u66f2\u59a5\u73e0\u5355\u6297\u5df2\u5148\u540e\u83b7\u5f97\u7f8e\u56fd\u548c\u6b27\u76df\u7684\u6279\u51c6\u4e0a\u5e02\uff0c\u6210\u4e3a\u5168\u7403\u9996\u4e2a\u7528\u4e8e\u6cbb\u7597HER2\u7a81\u53d8\u8f6c\u79fb\u6027\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u60a3\u8005\u7684\u9776\u5411\u836f\u7269\uff0c\u5e76\u83b7\u5f97\u7f8e\u56fd\u56fd\u7acb\u7efc\u5408\u764c\u75c7\u7f51\u7edc\uff08NCCN\uff09\u6307\u5357\u548c\u4e2d\u56fd\u4e34\u5e8a\u80bf\u7624\u5b66\u4f1a\uff08CSCO\uff09\u6307\u5357\u7684\u4e00\u81f4\u63a8\u8350[6],<\/sup>[7],<\/sup>[8]<\/sup>\u3002\u9274\u4e8eHER2\u7a81\u53d8\u5728\u4e9a\u6d32\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u60a3\u8005\u4e2d\u7a81\u53d8\u7684\u53d1\u751f\u7387\u66f4\u9ad8\uff0c\u8bc4\u4f30\u5fb7\u66f2\u59a5\u73e0\u5355\u6297\u5728\u4e9a\u6d32\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u4eba\u7fa4\u4e2d\u7684\u6cbb\u7597\u4ef7\u503c\u975e\u5e38\u91cd\u8981\u3002<\/p>\n

DESTINY-Lung05\u7814\u7a76\u662f\u4e00\u9879\u5728\u4e2d\u56fd\u5f00\u5c55\u7684\u5f00\u653e\u6027\u3001\u5355\u81c2\u3001\u591a\u4e2d\u5fc3\u7684DESTINY-Lung02\u6865\u63a5\u7814\u7a76\uff0c\u5171\u7eb3\u516572\u4f8bHER2\u7a81\u53d8\u7684\u7ecf\u6cbb\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u60a3\u8005\uff0c\u65e8\u5728\u8bc4\u4f30\u5fb7\u66f2\u59a5\u73e0\u5355\u62975.4mg\/kg\u5728\u81f3\u5c11\u63a5\u53d7\u4e00\u7ebf\u836f\u7269\u6cbb\u7597\u671f\u95f4\u6216\u6cbb\u7597\u4e4b\u540e\u75be\u75c5\u8fdb\u5c55\u3001\u643a\u5e26HER2 19\/20\u53f7\u5916\u663e\u5b50\u7a81\u53d8\u7684\u8f6c\u79fb\u6027\u975e\u9cde\u72b6\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u60a3\u8005\u7684\u7597\u6548\u548c\u5b89\u5168\u6027\u3002\u7ecfICR\u8bc4\u4f30\u7684\u4e3b\u8981\u7814\u7a76\u7ec8\u70b9\u5ba2\u89c2\u7f13\u89e3\u7387\uff08ORR\uff09\u4e3a58.3%\uff0895% CI: 46.1,69.8\uff09\uff1b\u75be\u75c5\u63a7\u5236\u7387\uff08 DCR\uff09\u4e3a91.7%\uff0895% CI:82.7,96.9\uff09\uff1b 12\u4e2a\u6708\u7684PFS\u7387\u4e3a55.1%\uff0895% CI:41.4,66.8\uff09\u3002ICR\u8bc4\u4f30\u7684PFS\u672a\u8fbe\u5230\uff0c\u7ecf\u7814\u7a76\u8005\u8bc4\u4f30\u7684\u4e2d\u4f4d\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\u4e3a10.8\u4e2a\u6708\uff0895% CI: 7.2,NE\uff09\u3002\u7814\u7a76\u7ed3\u679c\u8bc1\u5b9e\u4e86\u5fb7\u66f2\u59a5\u73e0\u5355\u6297\u5728\u4e2d\u56fdHER2\u7a81\u53d8\u7684\u665a\u671f\u80ba\u764c\u60a3\u8005\u4e2d\u5177\u6709\u663e\u8457\u7684\u6297\u80bf\u7624\u6d3b\u6027\uff0c\u4e0e\u603b\u4f53\u4eba\u7fa4\u3001\u4e9a\u6d32\u4e9a\u7ec4\u4eba\u7fa4\u7684\u83b7\u76ca\u8d8b\u52bf\u4e00\u81f4\uff0c\u4e14\u5b89\u5168\u6027\u53ef\u63a7\u53ef\u7ba1\u7406\u3002<\/p>\n

DESTINY-Lung05\u7814\u7a76\u7684\u9996\u5e2d\u7814\u7a76\u8005\u3001\u5409\u6797\u7701\u764c\u75c7\u4e2d\u5fc3\u4e3b\u4efb\u3001\u5409\u6797\u7701\u80ba\u764c\u8bca\u7597\u4e2d\u5fc3\u4e3b\u4efb\u3001\u56fd\u9645\u80ba\u764c\u8054\u76df\uff08IASLC\uff09\u7f55\u89c1\u80bf\u7624\u4e13\u59d4\u4f1a\u59d4\u5458\u7a0b\u9896\u6559\u6388\u8868\u793a\uff1a"\u6b64\u6b21\u516c\u5e03\u7684DESTINY-Lung05\u7814\u7a76\u6570\u636e\u8bc1\u5b9e\u4e86\u4e2d\u56fd\u60a3\u8005\u4f7f\u75285.4mg\/kg\u5fb7\u66f2\u59a5\u73e0\u5355\u6297\u8fdb\u884c\u6cbb\u7597\uff0c\u53ef\u5b9e\u73b0\u66f4\u597d\u7684\u98ce\u9669-\u83b7\u76ca\u5e73\u8861\u3002\u8fd9\u4e0d\u4ec5\u5f00\u542f\u4e86\u4e2d\u56fd\u80ba\u764c\u6297HER2\u6cbb\u7597\u65f6\u4ee3\uff0c\u800c\u4e14\u5bf9\u4e2d\u56fdHER2\u7a81\u53d8\u8f6c\u79fb\u6027\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u60a3\u8005\u7684\u6cbb\u7597\u6781\u5177\u6307\u5bfc\u610f\u4e49\uff0c\u589e\u5f3a\u4e86\u6211\u56fd\u4e34\u5e8a\u533b\u751f\u5bf9\u6cbb\u7597\u8fd9\u7c7b\u60a3\u8005\u7684\u4fe1\u5fc3\uff0c\u671f\u5f85\u8be5\u65b9\u6848\u80fd\u591f\u5c3d\u5feb\u5e94\u7528\u4e8e\u4e34\u5e8a\uff0c\u6539\u53d8\u5f53\u524d\u80ba\u764c\u7684\u6cbb\u7597\u683c\u5c40\uff0c\u7ed9\u66f4\u591a\u60a3\u8005\u5e26\u6765\u5e0c\u671b\u3002"<\/p>\n

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\u5173\u4e8eHER2\u7a81\u53d8\u975e\u5c0f\u7ec6\u80de\u80ba\u764c<\/b><\/p>\n

\u80ba\u764c\u662f\u5168\u7403\u7b2c\u4e8c\u5927\u5e38\u89c1\u80bf\u7624\uff0c2020\u5e74\u8d85\u8fc7\u4e24\u767e\u4e07\u60a3\u8005\u786e\u8bca\u4e3a\u8fd9\u4e00\u75be\u75c5[9]<\/sup>\u3002\u5bf9\u4e8e\u8f6c\u79fb\u6027\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u60a3\u8005\u800c\u8a00\uff0c\u75be\u75c5\u9884\u540e\u5c24\u5176\u5dee\uff0c\u53ea\u6709\u7ea68%\u7684\u60a3\u8005\u5728\u786e\u8bca\u540e\u53ef\u4ee5\u751f\u5b58\u4e94\u5e74\u4ee5\u4e0a[10]<\/sup>\u3002<\/p>\n

HER2\u662f\u4e00\u79cd\u916a\u6c28\u9178\u6fc0\u9176\u53d7\u4f53\u4fc3\u751f\u957f\u86cb\u767d\uff0c\u8868\u8fbe\u4e8e\u591a\u79cd\u80bf\u7624\u8868\u9762\uff0c\u5305\u62ec\u80ba\u764c\u3001\u4e73\u817a\u764c\u3001\u80c3\u764c\u548c\u7ed3\u76f4\u80a0\u764c\u3002\u67d0\u4e9bHER2\u57fa\u56e0\u6539\u53d8\uff08\u79f0\u4e3aHER2\u7a81\u53d8\uff09\u5df2\u5728\u975e\u9cde\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u60a3\u8005\u4e2d\u786e\u5b9a\u4e3a\u72ec\u7279\u7684\u5206\u5b50\u9776\u70b9\uff0c\u5728\u6b64\u7c7b\u80ba\u764c\u4e2d\u7ea6\u53602-4%[11],<\/sup>[12]<\/sup>\u3002<\/p>\n

\u867d\u7136HER2\u57fa\u56e0\u7a81\u53d8\u53ef\u4ee5\u53d1\u751f\u5728\u4e00\u7cfb\u5217\u60a3\u8005\u4e2d\uff0c\u4f46\u66f4\u5e38\u89c1\u4e8e\u5e74\u8f7b\u3001\u5973\u6027\u548c\u4ece\u672a\u5438\u70df\u7684\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u60a3\u8005[13]<\/sup>\u3002HER2\u57fa\u56e0\u7a81\u53d8\u4e0e\u764c\u7ec6\u80de\u751f\u957f\u548c\u4e0d\u826f\u9884\u540e\u72ec\u7acb\u76f8\u5173\uff0c\u4e14\u8111\u8f6c\u79fb\u7684\u53d1\u751f\u7387\u589e\u52a0[14]<\/sup>\u3002<\/p>\n

\u5c3d\u7ba1\u6297HER2\u6cbb\u7597\u5728\u4e73\u817a\u764c\u548c\u80c3\u764c\u4e2d\u7684\u5730\u4f4d\u5df2\u7ecf\u786e\u7acb\uff0c\u4f46\u5728\u7f8e\u56fd\u52a0\u901f\u6279\u51c6\u5fb7\u66f2\u59a5\u73e0\u5355\u6297\u7528\u4e8e\u4e0d\u53ef\u5207\u9664\u6216\u8f6c\u79fb\u6027HER2\u7a81\u53d8\u7684NSCLC\u4e4b\u524d\uff0c\u8fd8\u6ca1\u6709\u83b7\u6279\u7528\u4e8e\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u7684HER2\u9776\u5411\u7597\u6cd5[15]<\/sup>\u3002\u4e0b\u4e00\u4ee3\u6d4b\u5e8f\uff08NGS\uff09\u5df2\u7528\u4e8e\u9274\u5b9aHER2\uff08ERBB2\uff09\u7a81\u53d8[16]<\/sup>\u3002<\/p>\n

\u5173\u4e8eDESTINY-Lung02<\/b><\/p>\n

DESTINY-Lung02\u662f\u4e00\u9879\u5168\u7403\u968f\u673aII\u671f\u8bd5\u9a8c\uff0c\u65e8\u5728\u8bc4\u4f30\u5fb7\u66f2\u59a5\u73e0\u5355\u6297\u6cbb\u7597HER2m\u4e0d\u53ef\u5207\u9664\u548c\/\u6216\u8f6c\u79fb\u6027\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u60a3\u8005\u7684\u5b89\u5168\u6027\u548c\u7597\u6548\uff0c\u8fd9\u4e9b\u60a3\u8005\u5728\u63a5\u53d7\u81f3\u5c11\u4e00\u79cd\u6297\u764c\u6cbb\u7597\u65b9\u6848\uff08\u5fc5\u987b\u5305\u542b\u94c2\u7c7b\u5316\u7597\uff09\u671f\u95f4\u6216\u4e4b\u540e\u53d1\u751f\u75be\u75c5\u590d\u53d1\u6216\u8fdb\u5c55\u3002\u60a3\u8005\u63092:1\u968f\u673a\u63a5\u53d7\u5fb7\u66f2\u59a5\u73e0\u5355\u62975.4mg\/kg(n=102)\u62166.4mg\/kg(n=50)\u3002<\/p>\n

\u8be5\u8bd5\u9a8c\u7684\u4e3b\u8981\u7814\u7a76\u7ec8\u70b9\u662f\u7ecfBICR\u8bc4\u4f30\u7684\u786e\u5b9a\u7684ORR\u3002\u6b21\u8981\u7ec8\u70b9\u5305\u62ec\u7531\u7814\u7a76\u8005\u4ee5\u53caBICR\u8bc4\u4f30\u7684\u786e\u8ba4\u7684\u75be\u75c5\u63a7\u5236\u7387DCR\u3001DoR\u3001PFS\u3001OS\u548c\u5b89\u5168\u6027\u3002DESTINY-Lung02\u8bd5\u9a8c\u5728\u4e9a\u6d32\u3001\u6b27\u6d32\u548c\u5317\u7f8e\u5728\u5185\u7684\u591a\u5730\u62db\u52df\u4e86152\u540d\u60a3\u8005\u3002\u6709\u5173\u8bd5\u9a8c\u7684\u66f4\u591a\u4fe1\u606f\uff0c\u8bf7\u8bbf\u95eeClinicalTrials.gov\uff08NCT05246514\uff09\u3002<\/p>\n

\u5173\u4e8eDESTINY-Lung05<\/b><\/p>\n

II\u671fDESTINY-Lung05\u7814\u7a76\uff08NCT05246514\uff09\u662f\u4e00\u9879\u5728\u4e2d\u56fd\u5f00\u5c55\u7684\u5f00\u653e\u6027\u3001\u5355\u81c2\u3001\u591a\u4e2d\u5fc3\u7684DESTINY-Lung02\u6865\u63a5\u7814\u7a76\u3002\u8be5\u9879\u7814\u7a76\u7531\u5409\u6797\u7701\u80bf\u7624\u533b\u9662\u4f5c\u4e3a\u7275\u5934\u5355\u4f4d\uff0c\u5171\u7eb3\u516572\u4f8bHER2\u7a81\u53d8\u7ecf\u6cbbNSCLC\u60a3\u8005\u3002\u65e8\u5728\u8bc4\u4f30\u5fb7\u66f2\u59a5\u73e0\u5355\u62975.4mg\/kg\u5728\u81f3\u5c11\u63a5\u53d7\u4e00\u7ebf\u836f\u7269\u6cbb\u7597\u671f\u95f4\u6216\u6cbb\u7597\u4e4b\u540e\u75be\u75c5\u8fdb\u5c55\u3001\u643a\u5e26HER2 19\/20\u53f7\u5916\u663e\u5b50\u7a81\u53d8\u7684\u8f6c\u79fb\u6027\u975e\u9cde\u72b6NSCLC\u4e2d\u56fd\u60a3\u8005\u4e2d\u7684\u7597\u6548\u548c\u5b89\u5168\u6027\u3002\u4e3b\u8981\u7ec8\u70b9\u4e3aICR\u8bc4\u4f30\u7684ORR\uff0c\u6b21\u8981\u7ec8\u70b9\u4e3a\u7814\u7a76\u8005\u8bc4\u4f30\u7684ORR\uff0c\u7814\u7a76\u8005\u548cICR\u8bc4\u4f30\u7684DCR\u3001DoR\u3001PFS\u3001OS\u548c\u5b89\u5168\u6027\u7b49\u3002<\/p>\n

\u5173\u4e8e\u5fb7\u66f2\u59a5\u73e0\u5355\u6297<\/b><\/p>\n

\u5fb7\u66f2\u59a5\u73e0\u5355\u6297\u662f\u4e00\u79cd\u9776\u5411HER2\u7684ADC\u3002\u5fb7\u66f2\u59a5\u73e0\u5355\u6297\u91c7\u7528\u7b2c\u4e00\u4e09\u5171\u4e13\u6709\u7684DXd ADC\u6280\u672f\u8bbe\u8ba1\uff0c\u662f\u7b2c\u4e00\u4e09\u5171\u80bf\u7624\u4ea7\u54c1\u7ec4\u5408\u4e2d\u9886\u5148\u7684ADC\uff0c\u4e5f\u662f\u963f\u65af\u5229\u5eb7ADC\u79d1\u5b66\u5e73\u53f0\u4e2d\u6700\u5148\u8fdb\u7684\u9879\u76ee\u3002\u5fb7\u66f2\u59a5\u73e0\u5355\u6297\u7531\u4eba\u6e90\u5316\u6297HER2\u5355\u514b\u9686\u6297\u4f53\u901a\u8fc7\u7a33\u5b9a\u7684\u53ef\u88c2\u89e3\u56db\u80bd\u8fde\u63a5\u5b50\u4e0e\u62d3\u6251\u5f02\u6784\u9176-I\u6291\u5236\u5242\uff08\u559c\u6811\u78b1\u7c7b\u884d\u751f\u7269DXd\uff09\u8fde\u63a5\u7ec4\u6210\u3002<\/p>\n

\u57fa\u4e8eDESTINY-Breast03\u8bd5\u9a8c\u7684\u7ed3\u679c\uff0c\u5fb7\u66f2\u59a5\u73e0\u5355\u6297\uff085.4mg\/kg\uff09\u572850\u591a\u4e2a\u56fd\u5bb6\u88ab\u6279\u51c6\u7528\u4e8e\u65e2\u5f80\u5728\u8f6c\u79fb\u9636\u6bb5\u63a5\u53d7\u8fc7\uff08\u6216\u4e00\u79cd\u6216\u591a\u79cd\uff09\u6297HER2\u6cbb\u7597\u65b9\u6848\uff0c\u6216\u5728\u65b0\u8f85\u52a9\u6cbb\u7597\u671f\u95f4\u6216\u8f85\u52a9\u6cbb\u7597\u4e4b\u540e6\u4e2a\u6708\u5185\u51fa\u73b0\u75be\u75c5\u590d\u53d1\u7684\u4e0d\u53ef\u5207\u9664\u6216\u8f6c\u79fb\u6027HER2\u9633\u6027\u6210\u4eba\u4e73\u817a\u764c\u60a3\u8005\u3002<\/p>\n

\u57fa\u4e8eDESTINY-Breast04\u8bd5\u9a8c\u7684\u7ed3\u679c\uff0c\u5fb7\u66f2\u59a5\u73e0\u5355\u6297\uff085.4mg\/kg\uff09\u572840\u591a\u4e2a\u56fd\u5bb6\u88ab\u6279\u51c6\u7528\u4e8e\u6cbb\u7597\u4e0d\u53ef\u5207\u9664\u6216\u8f6c\u79fb\u6027HER2-low\uff08IHC 1+\u6216IHC 2+\/ISH\u9634\u6027\uff09\u4e73\u817a\u764c\u7684\u6210\u4eba\u60a3\u8005\uff0c\u8fd9\u4e9b\u60a3\u8005\u5728\u8f6c\u79fb\u9636\u6bb5\u4e2d\u63a5\u53d7\u8fc7\u4e00\u6b21\u5168\u8eab\u6cbb\u7597\u6216\u5728\u5b8c\u6210\u8f85\u52a9\u5316\u7597\u671f\u95f4\u6216\u516d\u4e2a\u6708\u5185\u75be\u75c5\u590d\u53d1\u3002<\/p>\n

\u57fa\u4e8eDESTINY-Lung01\u548cDESTINY-Lung02\u7814\u7a76\u7684\u7a81\u7834\u6027\u6210\u679c\uff0c\u5fb7\u66f2\u59a5\u73e0\u5355\u6297\uff085.4 mg\/kg\uff09\u6cbb\u7597HER2\u7a81\u53d8NCSLC\u7684\u9002\u5e94\u8bc1\u5df2\u5148\u540e\u83b7\u5f97\u7f8e\u56fdFDA\u3001\u65e5\u672c\u548c\u6b27\u76df\u7684\u6279\u51c6\uff0c\u6210\u4e3a\u9996\u4e2a\u83b7\u6279\u7528\u4e8eHER2\u7a81\u53d8\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u7684\u836f\u7269\uff0c\u5e76\u4e14NCCN\u3001ASCO\u3001CSCO\u7b49\u56fd\u5185\u5916\u6743\u5a01\u6307\u5357\u5171\u8bc6\u5747\u63a8\u8350\u5fb7\u66f2\u59a5\u73e0\u5355\u6297\u4f5c\u4e3a\u7ecf\u6cbbHER2\u7a81\u53d8\u665a\u671fNSCLC\u60a3\u8005\u7684\u6807\u51c6\u6cbb\u7597\u3002\u5bf9\u8be5\u9002\u5e94\u75c7\u7684\u6301\u7eed\u6279\u51c6\u53ef\u80fd\u53d6\u51b3\u4e8e\u9a8c\u8bc1\u6027\u8bd5\u9a8c\u4e2d\u5bf9\u4e34\u5e8a\u76ca\u5904\u7684\u9a8c\u8bc1\u548c\u63cf\u8ff0\u3002\u57fa\u4e8eDESTINY-Gastric01\u548c\/\u6216DESTINY-Gastric02\u8bd5\u9a8c\u7684\u7ed3\u679c\uff0c\u5fb7\u66f2\u59a5\u73e0\u5355\u6297\uff086.4mg\/kg\uff09\u572830\u591a\u4e2a\u56fd\u5bb6\u88ab\u6279\u51c6\u7528\u4e8e\u6cbb\u7597\u63a5\u53d7\u8fc7\u4ee5\u66f2\u59a5\u73e0\u5355\u6297\u4e3a\u57fa\u7840\u6cbb\u7597\u540e\u8fdb\u5c55\u7684HER2\u9633\u6027\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u80c3\u764c\u6216\u80c3\u98df\u7ba1\u4ea4\u754c\u5904\u817a\u764c\u6210\u4eba\u60a3\u8005\u3002<\/p>\n

\u5173\u4e8e\u5fb7\u66f2\u59a5\u73e0\u5355\u6297\u4e34\u5e8a\u7814\u53d1\u8ba1\u5212<\/b><\/p>\n

\u8bc4\u4f30\u5fb7\u66f2\u59a5\u73e0\u5355\u6297\u5355\u836f\u5728\u591a\u79cdHER2\u9776\u5411\u764c\u75c7\u4e2d\u7684\u7597\u6548\u548c\u5b89\u5168\u6027\u7684\u5168\u9762\u7814\u53d1\u8ba1\u5212\u6b63\u5728\u5168\u7403\u8303\u56f4\u5185\u8fdb\u884c\uff0c\u8054\u5408\u514d\u75ab\u6cbb\u7597\u7b49\u5176\u4ed6\u6297\u80bf\u7624\u6cbb\u7597\u7684\u8bd5\u9a8c\u4e5f\u5728\u8fdb\u884c\u4e2d\u3002<\/p>\n

\u5173\u4e8e\u4e0e\u7b2c\u4e00\u4e09\u5171\u7684\u5408\u4f5c<\/b><\/p>\n

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\u5173\u4e8e\u963f\u65af\u5229\u5eb7\u5728\u80ba\u764c\u9886\u57df\u7684\u7814\u7a76<\/b><\/p>\n

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\u58f0\u660e\uff1a\u672c\u6587\u53ef\u80fd\u6d89\u53ca\u5c1a\u672a\u5728\u4e2d\u56fd\u83b7\u6279\u7684\u4ea7\u54c1\u6216\u9002\u5e94\u75c7\uff0c\u963f\u65af\u5229\u5eb7\u4e0d\u63a8\u8350\u4efb\u4f55\u672a\u88ab\u6279\u51c6\u7684\u836f\u54c1\u4f7f\u7528\u3002<\/i><\/p>\n

\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
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\u53c2\u8003\u6587\u732e <\/b><\/span><\/p>\n<\/td>\n<\/tr>\n

\n

1.          Zheng R, Zhang S, Zeng H, et al.. Cancer incidence and mortality in China, 2016. J Natl Cancer Cent, 2022, 2(1): 1-9. doi: 10.1016\/j.jncc.2022.02.002<\/span><\/p>\n<\/td>\n<\/tr>\n

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2.          Nützinger J, Bum Lee J, Li Low J, Ling Chia P, Talisa Wijaya S, Chul Cho B, Min Lim S, Soo RA. Management of HER2 alterations in non-small cell lung cancer – The past, present, and future. Lung Cancer. 2023 Sep 28;186:107385.<\/span><\/p>\n<\/td>\n<\/tr>\n

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3.          Wen S, Dai L, Wang L, et al. Genomic Signature of Driver Genes Identified by Target Next-Generation Sequencing in Chinese Non-Small Cell Lung Cancer. Oncologist. 2019 Nov;24(11):e1070-e1081.<\/span><\/p>\n<\/td>\n<\/tr>\n

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4.          \u65af\u9526\u68d0,\u7b49. HER2\u57fa\u56e0\u7a81\u53d8\u665a\u671f\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u6cbb\u7597\u8fdb\u5c55[J]. \u80bf\u7624\u836f\u5b66. 2023; 13(4): 395-406<\/span><\/p>\n<\/td>\n<\/tr>\n

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5.          Goto K, Goto Y, Kubo T, et al. Trastuzumab deruxtecan (T-DXd) in Asian patients (Pts) with human epidermal growth factor receptor 2 (HER2; ERBB2)-mutant (HER2m) metastatic non-small cell lung cancer (mNSCLC): Subgroup analysis of DESTINY\u2013Lung02 (DL-02). 2023 ESMO Asia 510MO.<\/span><\/p>\n<\/td>\n<\/tr>\n

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6.          FDA grants accelerated approval to fam-trastuzumab deruxtecan-nxki for HER2-mutant non-small cell lung cancer. https:\/\/www.fda.gov\/drugs\/resources-information-approved-drugs\/fda-grants-accelerated-approval-fam-trastuzumab-deruxtecan-nxki-her2-mutant-non-small-cell-lung.<\/span><\/p>\n<\/td>\n<\/tr>\n

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7.          NCCN Guideline non-small cell lung cancer V4.2022<\/span><\/p>\n<\/td>\n<\/tr>\n

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8.          CSCO \u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u8bca\u7597\u6307\u5357\uff082023\u7248\uff09<\/span><\/p>\n<\/td>\n<\/tr>\n

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9.          WHO. International Agency of Cancer Research. Cancer Today. 2020. Available at: https:\/\/gco.iarc.fr\/today\/home. Accessed September 2022.<\/span><\/p>\n<\/td>\n<\/tr>\n

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10.      American Cancer Society. Lung Cancer Survival Rates. Available at: https:\/\/www.cancer.org\/cancer\/lung-cancer\/detection-diagnosis-staging\/survival-rates.html. Accessed September 2022.<\/span><\/p>\n<\/td>\n<\/tr>\n

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11.      Liu S, et al. Targeting HER2 Aberrations in Non\u2013Small Cell Lung Cancer with Osimertinib. Clin Cancer Res. 2018;24(11):2594-2604.<\/span><\/p>\n<\/td>\n<\/tr>\n

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12.      Riudavets M, et al. Targeting HER2 in non-small-cell lung cancer (NSCLC): a glimpse of hope? An updated review on therapeutic strategies in NSCLC harbouring HER2 alterations. ESMO Open. 2021;6(5):100260.<\/span><\/p>\n<\/td>\n<\/tr>\n

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13.      Pillai RN, et al. HER2 mutations in lung adenocarcinomas: A report from the Lung Cancer Mutation Consortium. Cancer. 2017;123:4099-105.<\/span><\/p>\n<\/td>\n<\/tr>\n

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14.      Offin M, et al. Frequency and Outcomes of Brain Metastases in Patients With HER2-Mutant Lung Cancers. Cancer. 2019;125:4380-7.<\/span><\/p>\n<\/td>\n<\/tr>\n

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15.      Zhou J, et al. Clinical outcomes of patients with HER2-mutant advanced lung cancer: chemotherapies versus HER2-directed therapies. Ther Adv Med Oncol. 2020;12.<\/span><\/p>\n<\/td>\n<\/tr>\n

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16.      Hechtman J, et al. The Past, Present, and Future of HER2 (ERBB2) in Cancer: Approaches to Molecular Testing and an Evolving Role in Targeted Therapy. Cancer Cyto. 2019;127(7):428-431.<\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table><\/div>\n

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