{"id":109916,"date":"2024-04-02T12:00:00","date_gmt":"2024-04-02T05:00:00","guid":{"rendered":"https:\/\/www.xinwengao.com\/cn\/pr\/20240402120000109916"},"modified":"2024-04-03T05:22:59","modified_gmt":"2024-04-02T21:22:59","slug":"%e4%bf%a1%e8%be%be%e7%94%9f%e7%89%a9%e4%b8%8e%e5%92%8c%e9%bb%84%e5%8c%bb%e8%8d%af%e5%ae%a3%e5%b8%83%e4%bf%a1%e8%bf%aa%e5%88%a9%e5%8d%95%e6%8a%97%e8%81%94%e5%90%88%e5%91%8b%e5%96%b9%e6%9b%bf%e5%b0%bc","status":"publish","type":"post","link":"https:\/\/www.xinwengao.com\/cn\/pr\/20240402120000109916","title":{"rendered":"\u4fe1\u8fbe\u751f\u7269\u4e0e\u548c\u9ec4\u533b\u836f\u5ba3\u5e03\u4fe1\u8fea\u5229\u5355\u6297\u8054\u5408\u544b\u55b9\u66ff\u5c3c\u7528\u4e8e\u6cbb\u7597\u665a\u671f\u5b50\u5bab\u5185\u819c\u764c\u7684\u4e2d\u56fd\u65b0\u836f\u4e0a\u5e02\u7533\u8bf7\u83b7\u53d7\u7406\u5e76\u83b7\u7eb3\u5165\u4f18\u5148\u5ba1\u8bc4"},"content":{"rendered":"<p><p><span class=\"legendSpanClass\">\u7f8e\u56fd\u7f57\u514b\u7ef4\u5c14\u548c\u4e2d\u56fd\u82cf\u5dde<\/span><span class=\"legendSpanClass\">2024\u5e744\u67082\u65e5<\/span> \/\u7f8e\u901a\u793e\/ &#8212; 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\u7814\u7a76\u7684\u6570\u636e\u5c06\u63d0\u4ea4\u4e8e\u8fd1\u671f\u7684\u5b66\u672f\u4f1a\u8bae\u4e0a\u53d1\u8868\u3002\u8be5\u9879\u7814\u7a76\u7684\u5176\u4ed6\u8be6\u60c5\u53ef\u767b\u5f55clinicaltrials.gov\uff0c\u68c0\u7d22\u6ce8\u518c\u53f7<a href=\"https:\/\/www.clinicaltrials.gov\/study\/NCT03903705\" target=\"_blank\" rel=\"nofollow noopener\">NCT03903705<\/a>\u67e5\u770b\u3002<\/p>\n<p><b>\u4fe1\u8fbe\u751f\u7269\u5236\u836f\u96c6\u56e2\u9ad8\u7ea7\u526f\u603b\u88c1\u5468\u8f89\u535a\u58eb<\/b>\u8868\u793a\uff1a&quot;\u8fbe\u4f2f\u8212<sup>&reg;<\/sup>\uff08\u4fe1\u8fea\u5229\u5355\u6297\u6ce8\u5c04\u6db2\uff09\u4f5c\u4e3a\u514d\u75ab\u80bf\u7624\u9886\u57df\u7684\u57fa\u77f3\u7597\u6cd5\uff0c\u4e0e\u6297\u8840\u7ba1\u751f\u6210\u836f\u7269\u8054\u5408\u4f7f\u7528\uff0c\u6709\u671b\u6539\u5584\u4e2d\u56fd\u5b50\u5bab\u5185\u819c\u764c\u60a3\u8005\u7684\u9884\u540e\u3002\u6211\u4eec\u5bf9\u65b0\u836f\u4e0a\u5e02\u7533\u8bf7\u83b7\u53d7\u7406\u5e76\u4e88\u4ee5\u4f18\u5148\u5ba1\u8bc4\u611f\u5230\u5174\u594b\uff0c\u8fd9\u589e\u52a0\u4e86\u6211\u4eec\u4e3a\u5b50\u5bab\u5185\u819c\u764c\u60a3\u8005\u5e26\u6765\u65b0\u7684\u6cbb\u7597\u9009\u62e9\u7684\u6f5c\u529b\uff0c\u540c\u65f6\u4e5f\u5c06\u5de9\u56fa\u8fbe\u4f2f\u8212<sup>&reg;<\/sup>\u5728\u4e2d\u56fd\u7684\u9886\u5bfc\u5730\u4f4d\u3002&quot;<\/p>\n<p><b>\u548c\u9ec4\u533b\u836f\u7814\u53d1\u8d1f\u8d23\u4eba\u53ca\u9996\u5e2d\u533b\u5b66\u5b98\u77f3\u660e\u535a\u58eb<\/b>\u8868\u793a\uff1a&quot;\u8fd9\u662f\u544b\u55b9\u66ff\u5c3c\u548c\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\u4fe1\u8fea\u5229\u5355\u6297\u8054\u5408\u7597\u6cd5\u7684\u9996\u4e2a\u76d1\u7ba1\u6ce8\u518c\u7533\u8bf7\u3002 \u8fd9\u4e5f\u6807\u5fd7\u7740\u5728\u4e2d\u56fd\u6211\u4eec\u5728\u6539\u5199\u8fd9\u79cd\u5177\u6709\u6311\u6218\u6027\u7684\u75be\u75c5\u7684\u6cbb\u7597\u683c\u5c40\u7684\u9053\u8def\u4e0a\u53c8\u8fc8\u51fa\u4e86\u91cd\u8981\u7684\u4e00\u6b65\u3002\u5b50\u5bab\u5185\u819c\u764c\u4ecd\u7136\u662f\u6700\u5e38\u89c1\u7684\u5987\u79d1\u6076\u6027\u80bf\u7624\u4e4b\u4e00\u3002 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417,000\u4f8b\u5b50\u5bab\u5185\u819c\u764c\u65b0\u75c7\uff0c\u5e76\u9020\u6210\u7ea6 97,000 \u4eba\u6b7b\u4ea1<sup>[3]<\/sup>\u3002\u5728\u4e2d\u56fd\uff0c2020\u5e74\u4f30\u8ba1\u65b0\u589e 82,000\u4f8b\u5b50\u5bab\u5185\u819c\u764c\u65b0\u75c7\uff0c\u5e76\u9020\u6210\u7ea6 17,000 \u4eba\u6b7b\u4ea1<sup>[4]<\/sup>\u3002\u5c3d\u7ba1\u65e9\u671f\u5b50\u5bab\u5185\u819c\u764c\u53ef\u4ee5\u901a\u8fc7\u624b\u672f\u5207\u9664\uff0c\u4f46\u590d\u53d1\u6027\u548c\/\u6216\u8f6c\u79fb\u6027\u5b50\u5bab\u5185\u819c\u764c\u9886\u57df\u4ecd\u7136\u5b58\u5728\u5de8\u5927\u672a\u6ee1\u8db3\u7684\u9700\u6c42\uff0c\u60a3\u8005\u7684\u6cbb\u7597\u7ed3\u679c\u4e0d\u4f73\u4e14\u6cbb\u7597\u9009\u62e9\u6709\u9650<sup>[5],[6],[7]<\/sup>\u3002<\/p>\n<p><b>\u5173\u4e8e\u4fe1\u8fea\u5229\u5355\u6297<\/b><\/p>\n<p>\u4fe1\u8fea\u5229\u5355\u6297\uff0c\u4e2d\u56fd\u5546\u54c1\u540d\u4e3a\u8fbe\u4f2f\u8212<sup>&reg;<\/sup>\uff08\u4fe1\u8fea\u5229\u5355\u6297\u6ce8\u5c04\u6db2\uff09\uff0c\u662f\u4fe1\u8fbe\u751f\u7269\u5236\u836f\u548c\u793c\u6765\u5236\u836f\u5171\u540c\u5408\u4f5c\u7814\u53d1\u7684\u5177\u6709\u56fd\u9645\u8d28\u91cf\u7684\u521b\u65b0PD-1\u6291\u5236\u5242\u836f\u7269\u3002\u4fe1\u8fea\u5229\u5355\u6297\u662f\u4e00\u79cd\u4eba\u7c7b\u514d\u75ab\u7403\u86cb\u767dG4\uff08IgG4\uff09\u5355\u514b\u9686\u6297\u4f53\uff0c\u80fd\u7279\u5f02\u6027\u7ed3\u5408T\u7ec6\u80de\u8868\u9762\u7684PD-1\u5206\u5b50\uff0c\u4ece\u800c\u963b\u65ad\u5bfc\u81f4\u80bf\u7624\u514d\u75ab\u8010\u53d7\u7684 PD-1\/\u7a0b\u5e8f\u6027\u6b7b\u4ea1\u53d7\u4f53\u914d\u4f531\uff08Programmed Death-Ligand 1, PD-L1\uff09\u901a\u8def\uff0c\u91cd\u65b0\u542f\u52a8\u6dcb\u5df4\u7ec6\u80de\u7684\u6297\u80bf\u7624\u6d3b\u6027\uff0c\u4ece\u800c\u8fbe\u5230\u6cbb\u7597\u80bf\u7624\u7684\u76ee\u7684<sup>[8]<\/sup>\u3002<\/p>\n<p>\u4fe1\u8fea\u5229\u5355\u6297\u5df2\u5728\u4e2d\u56fd\u83b7\u6279\u4e03\u9879\u9002\u5e94\u75c7\u5e76\u5168\u90e8\u7eb3\u5165\u56fd\u5bb6\u533b\u4fdd\u76ee\u5f55\uff0c\u534f\u8bae\u671f\u5185\u533b\u4fdd\u76ee\u5f55\u63cf\u8ff0\u7684\u9650\u5b9a\u652f\u4ed8\u8303\u56f4\u5305\u62ec\uff1a<\/p>\n<ul type=\"disc\">\n<li>\u81f3\u5c11\u7ecf\u8fc7\u4e8c\u7ebf\u7cfb\u7edf\u5316\u7597\u7684\u590d\u53d1\u6216\u96be\u6cbb\u6027\u7ecf\u5178\u578b\u970d\u5947\u91d1\u6dcb\u5df4\u7624\u7684\u6cbb\u7597\uff1b<\/li>\n<li>\u8868\u76ae\u751f\u957f\u56e0\u5b50\u53d7\u4f53\uff08EGFR\uff09\u57fa\u56e0\u7a81\u53d8\u9634\u6027\u548c\u95f4\u53d8\u6027\u6dcb\u5df4\u7624\u6fc0\u9176(ALK)\u9634\u6027\u3001 \u4e0d\u53ef\u624b\u672f\u5207\u9664\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u975e\u9cde\u72b6\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff08NSCLC\uff09\u7684\u4e00\u7ebf\u6cbb\u7597\uff1b<\/li>\n<li>\u8868\u76ae\u751f\u957f\u56e0\u5b50\u53d7\u4f53\u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5242\uff08EGFR-TKI\uff09 \u6cbb\u7597\u5931\u8d25\u7684 EGFR \u57fa\u56e0\u7a81\u53d8\u9633\u6027\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u975e\u9cde\u72b6\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff08NSCLC\uff09 \u60a3\u8005\u7684\u6cbb\u7597\uff1b<\/li>\n<li>\u4e0d\u53ef\u624b\u672f\u5207\u9664\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u9cde\u72b6\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff08NSCLC\uff09\u7684\u4e00\u7ebf\u6cbb\u7597\uff1b<\/li>\n<li>\u65e2\u5f80\u672a\u63a5\u53d7\u8fc7\u7cfb\u7edf\u6cbb\u7597\u7684\u4e0d\u53ef\u5207\u9664\u6216\u8f6c\u79fb\u6027\u809d\u7ec6\u80de\u764c\u7684\u4e00\u7ebf\u6cbb\u7597\uff1b<\/li>\n<li>\u4e0d\u53ef\u5207\u9664\u7684\u5c40\u90e8\u665a\u671f\u3001\u590d\u53d1\u6216\u8f6c\u79fb\u6027\u98df\u7ba1\u9cde\u764c\u7684\u4e00\u7ebf\u6cbb\u7597\uff1b<\/li>\n<li>\u4e0d\u53ef\u5207\u9664\u7684\u5c40\u90e8\u665a\u671f\u3001\u590d\u53d1\u6216\u8f6c\u79fb\u6027\u80c3\u53ca\u80c3\u98df\u7ba1\u4ea4\u754c\u5904\u817a\u764c\u7684\u4e00\u7ebf\u6cbb\u7597\u3002<\/li>\n<\/ul>\n<p>\u6b64\u5916\uff0c\u4fe1\u8fea\u5229\u5355\u6297\u8054\u5408\u544b\u55b9\u66ff\u5c3c\u7684\u8054\u5408\u7597\u6cd5\u7528\u4e8e\u6cbb\u7597\u65e2\u5f80\u7cfb\u7edf\u6027\u6297\u80bf\u7624\u6cbb\u7597\u540e\u75be\u75c5\u8fdb\u5c55\u4e14\u4e0d\u9002\u5408\u8fdb\u884c\u6839\u6cbb\u6027\u624b\u672f\u6cbb\u7597\u6216\u6839\u6cbb\u6027\u653e\u7597\u7684\u665a\u671f\u9519\u914d\u4fee\u590d\u5b8c\u6574\uff08pMMR\uff09\u6216\u975e\u5fae\u536b\u661f\u9ad8\u5ea6\u4e0d\u7a33\u5b9a\uff08\u975eMSI-H\uff09\u7684\u5b50\u5bab\u5185\u819c\u764c\u60a3\u8005\u7684\u65b0\u836f\u4e0a\u5e02\u7533\u8bf7\u5df2\u83b7\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u53d7\u7406\u5e76\u4e88\u4ee5\u4f18\u5148\u5ba1\u8bc4\u3002<\/p>\n<p>\u4fe1\u8fea\u5229\u5355\u6297\u53e6\u6709\u4e24\u9879\u4e34\u5e8a\u8bd5\u9a8c\u8fbe\u5230\u7814\u7a76\u7ec8\u70b9\uff0c\u5305\u62ec\uff1a<\/p>\n<ul type=\"disc\">\n<li>\u5355\u836f\u7528\u4e8e\u665a\u671f\/\u8f6c\u79fb\u6027\u98df\u7ba1\u9cde\u764c\u4e8c\u7ebf\u6cbb\u7597\u7684II\u671f\u4e34\u5e8a\u7814\u7a76\uff1b<\/li>\n<li>\u5355\u836f\u7528\u4e8e\u542b\u94c2\u5316\u7597\u5931\u8d25\u7684\u665a\u671f\u9cde\u72b6\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u4e8c\u7ebf\u6cbb\u7597\u7684III\u671f\u4e34\u5e8a\u7814\u7a76\u3002<\/li>\n<\/ul>\n<p><i>\u58f0\u660e\uff1a\u4fe1\u8fbe\u751f\u7269\u4e0d\u63a8\u8350\u672a\u83b7\u6279\u7684\u836f\u54c1<\/i><i>\/\u9002\u5e94\u75c7\u7684\u4f7f\u7528\u3002<\/i><\/p>\n<p><b>\u5173\u4e8e\u544b\u55b9\u66ff\u5c3c<\/b><\/p>\n<p>\u544b\u55b9\u66ff\u5c3c\u662f\u4e00\u79cd\u9009\u62e9\u6027\u7684\u53e3\u670d\u8840\u7ba1\u5185\u76ae\u751f\u957f\u56e0\u5b50\u53d7\u4f53\uff08VEGFR\uff09-1\u3001-2\u53ca-3\u6291\u5236\u5242\u3002VEGFR\u6291\u5236\u5242\u5728\u6291\u5236\u80bf\u7624\u7684\u8840\u7ba1\u751f\u6210\u4e2d\u8d77\u5230\u81f3\u5173\u91cd\u8981\u7684\u4f5c\u7528\u3002\u544b\u55b9\u66ff\u5c3c\u88ab\u8bbe\u8ba1\u4e3a\u62e5\u6709\u66f4\u9ad8\u7684\u6fc0\u9176\u9009\u62e9\u6027\uff0c\u65e8\u5728\u964d\u4f4e\u8131\u9776\u6fc0\u9176\u6d3b\u6027\uff0c\u4ece\u800c\u5b9e\u73b0\u66f4\u9ad8\u7684\u836f\u7269\u66b4\u9732\u3001\u5bf9\u9776\u70b9\u7684\u6301\u7eed\u8986\u76d6\u4ee5\u53ca\u5f53\u6f5c\u5728\u4f5c\u4e3a\u8054\u5408\u7597\u6cd5\u65f6\u62e5\u6709\u66f4\u9ad8\u7684\u7075\u6d3b\u5ea6\u3002\u8fc4\u4eca\u4e3a\u6b62\uff0c\u544b\u55b9\u66ff\u5c3c\u5c55\u793a\u51fa\u53ef\u63a7\u7684\u5b89\u5168\u6027\u7279\u5f81\uff0c\u5176\u4e0e\u5176\u4ed6\u6297\u80bf\u7624\u7597\u6cd5\u8054\u5408\u4f7f\u7528\u7684\u7814\u7a76\u6b63\u5728\u8fdb\u884c\u4e2d\u3002<\/p>\n<p><b>\u5173\u4e8e\u544b\u55b9\u66ff\u5c3c\u5728\u4e2d\u56fd\u83b7\u6279<\/b><\/p>\n<p>\u544b\u55b9\u66ff\u5c3c\u5df2\u4e8e\u4e2d\u56fd\u83b7\u6279\u4e0a\u5e02\uff0c\u7528\u4e8e\u65e2\u5f80\u63a5\u53d7\u8fc7\u6c1f\u5c3f\u5627\u5576\u7c7b\u3001\u5965\u6c99\u5229\u94c2\u548c\u4f0a\u7acb\u66ff\u5eb7\u4e3a\u57fa\u7840\u7684\u5316\u7597\uff0c\u4ee5\u53ca\u65e2\u5f80\u63a5\u53d7\u8fc7\u6216\u4e0d\u9002\u5408\u63a5\u53d7\u6297\u8840\u7ba1\u5185\u76ae\u751f\u957f\u56e0\u5b50\uff08VEGF\uff09\u6cbb\u7597\u3001\u6297\u8868\u76ae\u751f\u957f\u56e0\u5b50\u53d7\u4f53\uff08EGFR\uff09\u6cbb\u7597\uff08RAS\u91ce\u751f\u578b\uff09\u7684\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c\u60a3\u8005\uff0c\u5e76\u7531\u548c\u9ec4\u533b\u836f\u53ca\u793c\u6765\u5408\u4f5c\u7814\u53d1\u53ca\u4ee5\u5546\u54c1\u540d\u7231\u4f18\u7279<sup>&reg;<\/sup>\u4e0a\u5e02\u9500\u552e\u3002\u5176\u4e8e2020\u5e741\u6708\u83b7\u7eb3\u5165\u4e2d\u56fd\u56fd\u5bb6\u533b\u4fdd\u836f\u54c1\u76ee\u5f55\u3002\u5728\u4e2d\u56fd416\u4f8b\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c\u60a3\u8005\u4e2d\u5f00\u5c55\u7684\u544b\u55b9\u66ff\u5c3cIII\u671f\u5173\u952e\u6027\u6ce8\u518c\u7814\u7a76FRESCO\u7684\u7814\u7a76\u652f\u6301\u4e86\u544b\u55b9\u66ff\u5c3c\u5728\u4e2d\u56fd\u7684\u83b7\u6279\uff0c\u8be5\u7814\u7a76\u7684\u7ed3\u679c\u5df2\u4e8e\u300a\u7f8e\u56fd\u533b\u5b66\u4f1a\u6742\u5fd7\uff08JAMA\uff09\u300b\u4e0a<a href=\"https:\/\/jamanetwork.com\/journals\/jama\/fullarticle\/2685988\" target=\"_blank\" rel=\"nofollow noopener\">\u53d1\u8868<\/a>\u3002\u81ea\u544b\u55b9\u66ff\u5c3c\u5728\u4e2d\u56fd\u4e0a\u5e02\u4ee5\u6765\uff0c\u622a\u81f32023\u5e74\u5e74\u4e2d\u5df2\u7ecf\u60e0\u53ca\u8d85\u8fc78\u4e07\u540d\u7ed3\u76f4\u80a0\u764c\u60a3\u8005\u3002<\/p>\n<p><b>\u5173\u4e8e\u544b\u55b9\u66ff\u5c3c\u5728\u7f8e\u56fd\u83b7\u6279<\/b><\/p>\n<p>\u544b\u55b9\u66ff\u5c3c\u4e8e2023\u5e7411\u6708\u4e8e\u7f8e\u56fd\u83b7\u5f97\u6279\u51c6\uff0c\u7528\u4e8e\u6cbb\u7597\u65e2\u5f80\u66fe\u63a5\u53d7\u8fc7\u6c1f\u5c3f\u5627\u5576\u7c7b\u3001\u5965\u6c99\u5229\u94c2\u548c\u4f0a\u7acb\u66ff\u5eb7\u4e3a\u57fa\u7840\u7684\u5316\u7597\u3001\u6297VEGF\u6cbb\u7597\uff0c\u4ee5\u53ca\u6297EGFR\u6cbb\u7597\uff08\u82e5\u5c5eRAS\u91ce\u751f\u578b\u53ca\u533b\u5b66\u4e0a\u9002\u7528\uff09\u7684\u6210\u4eba\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c\u60a3\u8005\uff0c\u5e76\u7531\u6b66\u7530\u4ee5\u5546\u54c1\u540dFRUZAQLA&#x2122;\u4e0a\u5e02\u9500\u552e\u3002\u544b\u55b9\u66ff\u5c3c\u7684\u7f8e\u56fd\u83b7\u6279\u662f\u57fa\u4e8e\u4e24\u9879\u5927\u578bIII\u671f\u7814\u7a76\u7684\u6570\u636e\uff0c\u5305\u62ec\u5df2\u4e8e\u300a\u67f3\u53f6\u5200 (The Lancet)\u300b<a href=\"https:\/\/www.thelancet.com\/journals\/lancet\/article\/PIIS0140-6736(23)00772-9\/fulltext\" target=\"_blank\" rel=\"nofollow noopener\">\u53d1\u8868<\/a>\u7ed3\u679c\u7684\u56fd\u9645\u591a\u4e2d\u5fc3FRESCO-2\u7814\u7a76\u4ee5\u53ca\u4e2d\u56fd\u7684FRESCO\u7814\u7a76\u3002\u8fd9\u4e24\u9879\u7814\u7a76\u63a2\u7d22\u4e86\u544b\u55b9\u66ff\u5c3c\u8054\u5408\u6700\u4f73\u652f\u6301\u6cbb\u7597\u5bf9\u6bd4\u5b89\u6170\u5242\u8054\u5408\u6700\u4f73\u652f\u6301\u6cbb\u7597\u7528\u4e8e\u6cbb\u7597\u7ecf\u6cbb\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c\u60a3\u8005\u3002FRESCO\u548cFRESCO-2\u7814\u7a76\u5747\u8fbe\u5230\u4e86\u5176\u4e3b\u8981\u7ec8\u70b9\u53ca\u5173\u952e\u6b21\u8981\u7597\u6548\u7ec8\u70b9\uff0c\u5728\u5171734\u540d\u63a5\u53d7\u4e86\u544b\u55b9\u66ff\u5c3c\u6cbb\u7597\u7684\u60a3\u8005\u4e2d\u5c55\u793a\u51fa\u4e86\u4e00\u81f4\u7684\u83b7\u76ca\u3002\u5404\u9879\u7814\u7a76\u5747\u5c55\u793a\u51fa\u4e86\u4e00\u81f4\u7684\u5b89\u5168\u6027\u7279\u5f81\u3002\u6b66\u7530\u62e5\u6709\u5728\u4e2d\u56fd\u5185\u5730\u3001\u9999\u6e2f\u548c\u6fb3\u95e8\u4ee5\u5916\u8fdb\u4e00\u6b65\u5f00\u53d1\u3001\u5546\u4e1a\u5316\u548c\u751f\u4ea7\u544b\u55b9\u66ff\u5c3c\u7684\u5168\u7403\u72ec\u5bb6\u8bb8\u53ef\u3002<\/p>\n<p><b>\u5173\u4e8e\u4fe1\u8fbe\u751f\u7269<\/b><\/p>\n<p>&quot;\u59cb\u4e8e\u4fe1\uff0c\u8fbe\u4e8e\u884c&quot;\uff0c\u5f00\u53d1\u51fa\u8001\u767e\u59d3\u7528\u5f97\u8d77\u7684\u9ad8\u8d28\u91cf\u751f\u7269\u836f\uff0c\u662f\u4fe1\u8fbe\u751f\u7269\u7684\u4f7f\u547d\u548c\u76ee\u6807\u3002\u4fe1\u8fbe\u751f\u7269\u6210\u7acb\u4e8e2011\u5e74\uff0c\u81f4\u529b\u4e8e\u5f00\u53d1\u3001\u751f\u4ea7\u548c\u9500\u552e\u80bf\u7624\u3001\u4ee3\u8c22\u53ca\u5fc3\u8840\u7ba1\u3001\u81ea\u8eab\u514d\u75ab\u3001\u773c\u79d1\u7b49\u91cd\u5927\u75be\u75c5\u9886\u57df\u7684\u521b\u65b0\u836f\u7269\u3002\u516c\u53f8\u5df2\u670910\u6b3e\u4ea7\u54c1\u83b7\u5f97\u6279\u51c6\u4e0a\u5e02\uff0c\u540c\u65f6\u8fd8\u67093\u4e2a\u54c1\u79cd\u5728NMPA\u5ba1\u8bc4\u4e2d\uff0c5\u4e2a\u65b0\u836f\u5206\u5b50\u8fdb\u5165III\u671f\u6216\u5173\u952e\u6027\u4e34\u5e8a\u7814\u7a76\uff0c\u53e6\u5916\u8fd8\u670918\u4e2a\u65b0\u836f\u54c1\u79cd\u5df2\u8fdb\u5165\u4e34\u5e8a\u7814\u7a76\u3002\u516c\u53f8\u4e0e\u6d77\u5185\u5916\u836f\u4f01\u6df1\u5165\u5408\u4f5c\u52a0\u901f\u836f\u7269\u521b\u65b0\uff0c\u4e0e\u793c\u6765\u3001\u7f57\u6c0f\u3001\u8d5b\u8bfa\u83f2\u3001Adimab\u3001Incyte\u548cMD Anderson 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med.com\u6216\u5173\u6ce8\u6211\u4eec\u7684LinkedIn\u4e13\u9875\u3002<\/p>\n<p><b>\u524d\u77bb\u6027\u58f0\u660e<\/b><\/p>\n<p>\u672c\u65b0\u95fb\u7a3f\u6240\u53d1\u5e03\u7684\u4fe1\u606f\u4e2d\u53ef\u80fd\u4f1a\u5305\u542b\u67d0\u4e9b\u524d\u77bb\u6027\u8868\u8ff0\u3002\u8fd9\u4e9b\u8868\u8ff0\u672c\u8d28\u4e0a\u5177\u6709\u76f8\u5f53\u98ce\u9669\u548c\u4e0d\u786e\u5b9a\u6027\u3002\u5728\u4f7f\u7528&quot;\u9884\u671f&quot;\u3001&quot;\u76f8\u4fe1&quot;\u3001&quot;\u9884\u6d4b&quot;\u3001&quot;\u671f\u671b&quot;\u3001&quot;\u6253\u7b97&quot;\u53ca\u5176\u4ed6\u7c7b\u4f3c\u8bcd\u8bed\u8fdb\u884c\u8868\u8ff0\u65f6\uff0c\u51e1\u4e0e\u672c\u516c\u53f8\u6709\u5173\u7684\uff0c\u76ee\u7684\u5747\u662f\u8981\u6307\u660e\u5176\u5c5e\u524d\u77bb\u6027\u8868\u8ff0\u3002\u672c\u516c\u53f8\u5e76\u65e0\u4e49\u52a1\u4e0d\u65ad\u5730\u66f4\u65b0\u8fd9\u4e9b\u9884\u6d4b\u6027\u9648\u8ff0\u3002<\/p>\n<p>\u8fd9\u4e9b\u524d\u77bb\u6027\u8868\u8ff0\u4e43\u57fa\u4e8e\u672c\u516c\u53f8\u7ba1\u7406\u5c42\u5728\u505a\u51fa\u8868\u8ff0\u65f6\u5bf9\u672a\u6765\u4e8b\u52a1\u7684\u73b0\u6709\u770b\u6cd5\u3001\u5047\u8bbe\u3001\u671f\u671b\u3001\u4f30\u8ba1\u3001\u9884\u6d4b\u548c\u7406\u89e3\u3002\u8fd9\u4e9b\u8868\u8ff0\u5e76\u975e\u5bf9\u672a\u6765\u53d1\u5c55\u7684\u4fdd\u8bc1\uff0c\u4f1a\u53d7\u5230\u98ce\u9669\u3001\u4e0d\u786e\u6027\u53ca\u5176\u4ed6\u56e0\u7d20\u7684\u5f71\u54cd\uff0c\u6709\u4e9b\u4e43\u8d85\u51fa\u672c\u516c\u53f8\u7684\u63a7\u5236\u8303\u56f4\uff0c\u96be\u4ee5\u9884\u8ba1\u3002\u56e0\u6b64\uff0c\u53d7\u6211\u4eec\u7684\u4e1a\u52a1\u3001\u7ade\u4e89\u73af\u5883\u3001\u653f\u6cbb\u3001\u7ecf\u6d4e\u3001\u6cd5\u5f8b\u548c\u793e\u4f1a\u60c5\u51b5\u7684\u672a\u6765\u53d8\u5316\u53ca\u53d1\u5c55\u7684\u5f71\u54cd\uff0c\u5b9e\u9645\u7ed3\u679c\u53ef\u80fd\u4f1a\u4e0e\u524d\u77bb\u6027\u8868\u8ff0\u6240\u542b\u8d44\u6599\u6709\u8f83\u5927\u5dee\u522b\u3002<\/p>\n<div>\n<table border=\"0\" cellspacing=\"0\" cellpadding=\"1\" class=\"prnbcc\">\n<tbody>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">\u53c2\u8003\u6587\u732e<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">[1]&nbsp; \u9519\u914d\u4fee\u590d\u5b8c\u6574 (pMMR) =&nbsp; Mismatch Repair proficient.<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">[2]&nbsp; \u5fae\u536b\u661f\u9ad8\u5ea6\u4e0d\u7a33\u5b9a&nbsp;(MSI-H) =&nbsp; Microsatellite instability-high.<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">[3]&nbsp; <a href=\"https:\/\/gco.iarc.fr\/\" target=\"_blank\" class=\"prnews_a\" rel=\"nofollow noopener\">The Global Cancer Observatory<\/a>, <a href=\"https:\/\/gco.iarc.fr\/today\/data\/factsheets\/populations\/900-world-fact-sheets.pdf\" target=\"_blank\" class=\"prnews_a\" rel=\"nofollow noopener\">World Fact Sheet<\/a>. Accessed June 12, 2023.<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">[4]&nbsp; <a href=\"https:\/\/gco.iarc.fr\/\" target=\"_blank\" class=\"prnews_a\" rel=\"nofollow noopener\">The Global Cancer Observatory<\/a>, <a href=\"https:\/\/gco.iarc.fr\/today\/data\/factsheets\/populations\/160-china-fact-sheets.pdf\" target=\"_blank\" class=\"prnews_a\" rel=\"nofollow noopener\">China Fact Sheet<\/a>. Accessed June 12, 2023.<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">[5]&nbsp; Yi A, et al. Real-world characteristics and treatment pattern of patients with newly diagnosed endometrial cancer in China.&nbsp; <i>J Clin Oncol.<\/i> 2023;41, no. 16_suppl (June 01, 2023) e17613-e17613. DOI: 10.1200\/JCO.2023.41.16_suppl.e17613.<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">[6]&nbsp; Koppikar S, et al. Pan-Asian adapted ESMO Clinical Practice Guidelines for the diagnosis, treatment and follow-up of patients with endometrial cancer. <i>ESMO Open<\/i>. 2023;8(1):100774. DOI: 10.1016\/j.esmoop.2022.100774.<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">[7]&nbsp; Siegel RL, et al. Cancer statistics, 2023. <i>CA Cancer J Clin<\/i>. 2023;73(1):17-48. DOI:10.3322\/caac.21763.<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">[8] Wang J, Fei K, Jing H, et al. Durable blockade of PD-1 signaling links preclinical efficacy of sintilimab to its clinical benefit. mAbs 2019;11(8): 1443-1451.<\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table><\/div>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u7f8e\u56fd\u7f57\u514b\u7ef4\u5c14\u548c\u4e2d\u56fd\u82cf\u5dde2024\u5e744\u67082\u65e5 \/\u7f8e\u901a\u793e\/ &#8212; 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