{"id":109903,"date":"2024-04-02T13:39:00","date_gmt":"2024-04-02T06:39:00","guid":{"rendered":"https:\/\/www.xinwengao.com\/cn\/pr\/20240402133900109903"},"modified":"2024-04-03T05:22:01","modified_gmt":"2024-04-02T21:22:01","slug":"kinnate-%e7%94%9f%e7%89%a9%e5%88%b6%e8%8d%af%e5%85%ac%e5%8f%b8%e5%b0%86%e5%85%b6%e5%9c%a8%e7%a0%94%e7%9a%84%e6%b3%9b-raf-%e6%8a%91%e5%88%b6%e5%89%82exarafenib%e5%87%ba%e5%94%ae%e7%bb%99%e7%9a%ae","status":"publish","type":"post","link":"https:\/\/www.xinwengao.com\/cn\/pr\/20240402133900109903","title":{"rendered":"Kinnate \u751f\u7269\u5236\u836f\u516c\u53f8\u5c06\u5176\u5728\u7814\u7684\u6cdb RAF \u6291\u5236\u5242Exarafenib\u51fa\u552e\u7ed9\u76ae\u5c14\u6cd5\u4f2f"},"content":{"rendered":"<ul type=\"disc\">\n<li><i>Kinnate&nbsp;<\/i><i>\u5df2\u4e0e\u76ae\u5c14\u6cd5\u4f2f\u5c31<\/i><i>Exarafenib <\/i><i>\u548c\u5176\u4ed6\u6cdb<\/i><i>&nbsp;RAF <\/i><i>\u9879\u76ee\u8d44\u4ea7\u7684\u5168\u7403\u6743\u5229\u7b7e\u8ba2\u8d44\u4ea7\u8d2d\u4e70\u534f\u8bae<\/i><i>\uff08&quot;<\/i><i>APA&quot;<\/i><i>\uff09\u3002<\/i><\/li>\n<li><i>\u8be5\u4ea4\u6613\u65e8\u5728\u63a8\u8fdb<\/i><i>&nbsp;Kinnate \u6b64\u524d\u5ba3\u5e03\u7684\u6218\u7565\u5907\u9009\u65b9\u6848\u3002<\/i><\/li>\n<li><i>\u6b64\u6b21\u6536\u8d2d\u610f\u5728\u8fdb\u4e00\u6b65\u5f3a\u5316\u76ae\u5c14\u6cd5\u4f2f\u5728\u7cbe\u51c6\u80bf\u7624\u5b66\u9886\u57df\u7684\u52aa\u529b\uff0c\u5e76\u6709\u673a\u4f1a\u60e0\u53ca\u66f4\u591a\u9700\u8981\u9776\u5411\u6cbb\u7597\u7684<\/i><i>&nbsp;RAF \u548c RAS \u5b9e\u4f53\u7624\u60a3\u8005\u3002<\/i><\/li>\n<\/ul>\n<p><p><span class=\"legendSpanClass\">\u65e7\u91d1\u5c71\u3001\u5723\u5730\u4e9a\u54e5\u548c\u6cd5\u56fd\u5361\u65af\u7279\u5c14<\/span><span class=\"legendSpanClass\">2024\u5e744\u67082\u65e5<\/span> \/\u7f8e\u901a\u793e\/ &#8212;&nbsp;<span id=\"spanHghlt8928\">\u4e34\u5e8a<\/span>\u9636\u6bb5\u7cbe\u51c6\u80bf\u7624\u5b66\u516c\u53f8 Kinnate \u751f\u7269\u5236\u836f\u516c\u53f8\uff08\u7eb3\u65af\u8fbe\u514b\u80a1\u7968\u4ee3\u7801\uff1aKNTE\uff09\uff08\u4ee5\u4e0b\u7b80\u79f0&quot;Kinnate&quot;\u6216&quot;\u8be5\u516c\u53f8&quot;\uff09\u4e0e\u5168\u7403\u9886\u5148\u7684\u80bf\u7624\u5b66\u516c\u53f8\u2014\u2014\u76ae\u5c14\u6cd5\u4f2f\u96c6\u56e2<span id=\"spanHghlt88fc\">\u8fd1\u65e5<\/span>\u5ba3\u5e03\uff0c\u53cc\u65b9\u540c\u610f\u7b7e\u8ba2\u8d44\u4ea7\u8d2d\u4e70\u534f\u8bae\u3002\u6839\u636e\u534f\u8bae\uff0cKinnate\u540c\u610f\u5411\u76ae\u5c14\u6cd5\u4f2f\u51fa\u552e\u8be5\u516c\u53f8\u5728\u7814\u7684\u6cdb RAF \u6291\u5236\u5242 Exarafenib \u548c\u5176\u4ed6\u6cdb RAF \u9879\u76ee\u8d44\u4ea7\u3002\u6b64\u6b21\u5168\u7403\u6743\u5229\u51fa\u552e\u662f\u4e3a\u4e86\u8fdb\u4e00\u6b65\u63a8\u8fdbKinnate\u5148\u524d\u5ba3\u5e03\u7684\u6218\u7565\u5907\u9009\u65b9\u6848\u65b9\u9762\u7684\u63a2\u7d22\u3002<\/p>\n<p>Kinnate \u9996\u5e2d\u6267\u884c\u5b98&nbsp;Nima Farzan \u8868\u793a\uff1a&quot;\u6211\u4eec\u5f88\u9ad8\u5174\u80fd\u4e0e\u76ae\u5c14\u6cd5\u4f2f\u5408\u4f5c\uff0c\u4ed6\u4eec\u5728&nbsp;RAF \u548c&nbsp;RAS \u9a71\u52a8\u5b9e\u4f53\u7624\u9776\u5411\u6cbb\u7597\u7684\u5168\u7403\u5f00\u53d1\u548c\u5546\u4e1a\u5316\u65b9\u9762\u62e5\u6709\u4e30\u5bcc\u7684\u4e13\u4e1a\u77e5\u8bc6\u3002\u5c06&nbsp;Exarafenib \u548c\u6211\u4eec\u7684\u6cdb&nbsp;RAF \u9879\u76ee\u8d44\u4ea7\u51fa\u552e\u7ed9\u76ae\u5c14\u6cd5\u4f2f\u5c06\u6269\u5927\u8fd9\u4e9b\u9879\u76ee\u5728\u5168\u7403\u7684\u5f71\u54cd\u8303\u56f4\uff0c\u4f7f&nbsp;NRAS \u9a71\u52a8\u9ed1\u8272\u7d20\u7624\u548c&nbsp;BRAF \u9a71\u52a8\u5b9e\u4f53\u7624\u9776\u5411\u6cbb\u7597\u6709\u671b\u5f97\u5230\u8fdb\u4e00\u6b65\u53d1\u5c55\uff0c\u6709\u52a9\u5b9e\u73b0\u6211\u4eec\u5bf9\u6b64\u7c7b\u80bf\u7624\u60a3\u8005\u7684\u627f\u8bfa\u3002&quot;<\/p>\n<p>\u76ae\u5c14\u6cd5\u4f2f\u5236\u836f\u7814\u53d1\u8d1f\u8d23\u4eba&nbsp;Francesco Hofmann \u5219\u8868\u793a\uff1a&quot;\u6839\u636e\u8fc4\u4eca\u4e3a\u6b62\u83b7\u5f97\u7684\u4e34\u5e8a\u548c\u4e34\u5e8a\u524d\u6570\u636e\uff0c\u6211\u4eec\u8ba4\u4e3a&nbsp;Exarafenib \u4f5c\u4e3a\u4e00\u79cd\u9776\u5411\u5b9e\u4f53\u7624\uff08\u5982&nbsp;NRAS \u7a81\u53d8\u578b\u9ed1\u8272\u7d20\u7624\uff09\u7684\u6cdb&nbsp;RAF \u6291\u5236\u5242\uff0c\u6709\u671b\u5b9e\u73b0\u540c\u7c7b\u6700\u4f73\u7684\u4ea7\u54c1\u7279\u6027\u3002\u76ee\u524d\u5c1a\u65e0\u9488\u5bf9\u8be5\u7c7b\u578b\u9ed1\u8272\u7d20\u7624\u7684\u6cdb&nbsp;RAF \u6291\u5236\u5242\u83b7\u5f97\u6279\u51c6\u3002\u4ece&nbsp;Kinnate \u516c\u53f8\u6536\u8d2d\u7684&nbsp;Exarafenib \u548c\u5176\u4ed6\u6cdb&nbsp;RAF \u8ba1\u5212\u8d44\u4ea7\u662f\u5bf9\u6211\u4eec\u73b0\u6709\u7684&nbsp;BRAF \u548c&nbsp;MEK \u6291\u5236\u5242\u7ec4\u5408\u4ee5\u53ca&nbsp;Encorafenib\u3001Binimetinib \u7684\u8865\u5145\u3002\u6b64\u6b21\u6536\u8d2d\u5c06\u7ee7\u7eed\u63a8\u8fdb\u6211\u4eec\u5728\u7cbe\u51c6\u80bf\u7624\u5b66\u9886\u57df\u7684\u52aa\u529b\uff0c\u5e76\u4e3a\u6211\u4eec\u63d0\u4f9b\u4e86\u673a\u4f1a\u60e0\u53ca\u66f4\u591a\u6709&nbsp;RAF \u548c&nbsp;RAS \u5b9e\u4f53\u7624\u6cbb\u7597\u9700\u6c42\u7684\u60a3\u8005\u3002&quot;<\/p>\n<p>\u6839\u636e&nbsp;APA \u6761\u6b3e\uff0c\u76ae\u5c14\u6cd5\u4f2f\u5df2\u8d2d\u4e70&nbsp;Exarafenib \u548c\u5176\u4ed6\u6cdb&nbsp;RAF \u8d44\u4ea7\uff0c\u5e76\u5c06\u627f\u62c5\u4e0e\u8fd9\u4e9b\u8d44\u4ea7\u76f8\u5173\u7684\u5168\u90e8\u8fdb\u884c\u4e2d\u9879\u76ee\u548c\u6210\u672c\u3002Kinnate \u5c06\u83b7\u5f97\u9ad8\u8fbe&nbsp;3100 \u4e07\u7f8e\u5143\u7684\u603b\u5bf9\u4ef7\uff0c\u5176\u4e2d\u5305\u62ec\u4ea4\u5272\u65f6\u7684&nbsp;50 \u4e07\u7f8e\u5143\u4ee5\u53ca\u4e00\u7b14&nbsp;3050 \u4e07\u7f8e\u5143\u7684\u4ed8\u6b3e\uff0c\u4ed8\u6b3e\u6761\u4ef6\u4e3a\uff1a&nbsp;Exarafenib \u6216\u4efb\u4f55\u5176\u4ed6\u6536\u8d2d\u8d44\u4ea7\u7684\u9996\u6b21\u5173\u952e\u8bd5\u9a8c\u4e2d\u9996\u4f4d\u60a3\u8005\u7ed9\u836f\uff1b\u6216\u6839\u636eFDA \u52a0\u901f\u5ba1\u6279\u8ba1\u5212\u7533\u8bf7\u52a0\u901f\u5ba1\u6279&nbsp;Exarafenib \u6216\u4efb\u4f55\u5176\u4ed6\u6240\u6536\u8d2d\u8d44\u4ea7\uff1b\u6216\u4e3a&nbsp;Exarafenib \u6216\u4efb\u4f55\u5176\u4ed6\u6536\u8d2d\u8d44\u4ea7\u63d0\u4ea4\u4e0a\u5e02\u7533\u8bf7\u4ee5\u83b7\u5f97\u76d1\u7ba1\u6279\u51c6\uff0c\u4e0a\u8ff0\u6761\u4ef6\u4ee5\u8f83\u65e9\u53d1\u751f\u8005\u4e3a\u51c6\u3002\u6b64\u5916\uff0c\u76ae\u5c14\u6cd5\u4f2f\u5c06\u4e3a\u6240\u8f6c\u8ba9\u7684\u8d44\u4ea7\u627f\u62c5\u9ad8\u8fbe&nbsp;500 \u4e07\u7f8e\u5143\u7684\u5e94\u4ed8\u8d26\u6b3e\u3002\u8be5\u4ea4\u6613\u4e0d\u53d7\u4ea4\u5272\u6761\u4ef6\u7684\u7ea6\u675f\uff0c\u5e76\u5df2\u4e8e\u7b7e\u7f72\u65f6\u4ea4\u5272\u3002<\/p>\n<p>\u6839\u636e\u4e4b\u524d\u5ba3\u5e03\u7684&nbsp;Kinnate \u4e0e&nbsp;XOMA Corporation\uff08&quot;XOMA&quot;\uff09\u4ea4\u6613\u5185\u5bb9\uff0c\u5047\u8bbe&nbsp;XOMA \u7684\u62df\u8bae\u4ea4\u6613\u4f9d\u636eCVR \u534f\u8bae\u5b8c\u6210\u4ea4\u5272\uff0c\u4e14\u81ea\u8be5\u4ea4\u5272\u65e5\u8d77\u4e94\u5e74\u5185\u6536\u5230\u6536\u76ca\uff0c\u5219Kinnate \u80a1\u4e1c\u5c06\u83b7\u5f97\uff08\u6263\u9664\u62df\u8bae&nbsp;XOMA \u4ea4\u6613\uff08&quot;CVR \u534f\u8bae&quot;\uff09\u5c06\u7b7e\u8ba2\u7684\u300a\u6216\u6709\u4ef7\u503c\u6743\u534f\u8bae\u300b\u4e2d\u7ea6\u5b9a\u7684\u9002\u7528\u6210\u672c\u3001\u8d39\u7528\u3001\u7a0e\u6b3e\u6216\u5176\u4ed6\u6263\u6b3e\u540e\u7684\uff09100%\u51c0\u6536\u76ca\uff0c\u8be5\u6536\u76ca\u5e94\u4ece&nbsp;3050 \u4e07\u7f8e\u5143\u7684\u6216\u6709\u4ed8\u6b3e\u4e2d\u652f\u4ed8\u300250 \u4e07\u7f8e\u5143\u7684\u4ea4\u5272\u4ed8\u6b3e\u4e2d\u4ec5\u5305\u542b\u4ea4\u6613\u8d39\u7528\uff0c\u4e0d\u4f1a\u4ea7\u751f\u51c0\u6536\u76ca\u3002<\/p>\n<p>Lazard \u62c5\u4efb Kinnate \u516c\u53f8\u7684\u8d22\u52a1\u987e\u95ee\uff0cWilson Sonsini Goodrich &amp; Rosati \u62c5\u4efb\u6cd5\u5f8b\u987e\u95ee\u3002<\/p>\n<p><b>\u5173\u4e8e<\/b><b>&nbsp;Kinnate <\/b><b>\u751f\u7269\u5236\u836f\u516c\u53f8<\/b><\/p>\n<p>Kinnate \u751f\u7269\u5236\u836f\u516c\u53f8\u662f\u4e00\u5bb6\u4e34\u5e8a\u9636\u6bb5\u7cbe\u51c6\u80bf\u7624\u5b66\u516c\u53f8\uff0c\u5176\u6210\u7acb\u7684\u4f7f\u547d\u662f\u901a\u8fc7\u6269\u5927\u9776\u5411\u6cbb\u7597\u7684\u524d\u666f\uff0c\u4e3a\u90a3\u4e9b\u4e0e\u764c\u75c7\u4f5c\u6597\u4e89\u7684\u4eba\u4eec\u5e26\u6765\u5e0c\u671b\u3002\u8be5\u516c\u53f8\u81f4\u529b\u4e8e\u89e3\u51b3\u76ee\u524d\u5c1a\u65e0\u83b7\u6279\u9776\u5411\u7597\u6cd5\u7684\u5df2\u77e5\u81f4\u764c\u7a81\u53d8\uff0c\u514b\u670d\u73b0\u6709\u764c\u75c7\u6cbb\u7597\u65b9\u6848\u5b58\u5728\u7684\u5c40\u9650\u6027\uff0c\u4f8b\u5982\u65e0\u514d\u75ab\u5e94\u7b54\u3001\u83b7\u5f97\u6027\u8010\u836f\u6027\u548c\u56fa\u6709\u8010\u836f\u6027\u3002<\/p>\n<p>Exarafenib \u662f\u4e00\u79cd\u5728\u7814\u7684\u6cdb&nbsp;RAF \u6291\u5236\u5242\uff0c\u4e3b\u8981\u9488\u5bf9\u643a\u5e26&nbsp;BRAF \u548c&nbsp;NRAS \u57fa\u56e0\u9a71\u52a8\u7684\u764c\u75c7\uff0c\u662f\u8be5\u516c\u53f8\u7684\u4e3b\u8981\u5019\u9009\u836f\u54c1\u4e4b\u4e00\u3002\u8be5\u516c\u53f8\u7684\u53e6\u4e00\u4e2a\u4e3b\u529b\u836f\u54c1\u662f\u4e00\u79cd\u5728\u7814\u4e2d\u7684&nbsp;FGFR \u6291\u5236\u5242&nbsp;KIN-3248\uff0c\u4e13\u95e8\u7528\u4e8e\u6cbb\u7597\u643a\u5e26&nbsp;FGFR2 \u548c&nbsp;FGFR3 \u7a81\u53d8\u7684\u764c\u75c7\u3002\u8be5\u516c\u53f8\u8fd8\u62e5\u6709\u5c1a\u5904\u4e8e\u521d\u671f\u7684\u9879\u76ee\uff0c\u5982\u9488\u5bf9\u8010\u836f\u53d8\u5f02\u7684&nbsp;c-MET \u6291\u5236\u5242\u548c\u4e00\u4e2a\u5177\u5907\u8111\u6e17\u900f\u6027\u53ca&nbsp;CDK4 \u9009\u62e9\u6027\u7684\u836f\u7269\u9879\u76ee\u3002\u6b32\u4e86\u89e3\u66f4\u591a\u4fe1\u606f\uff0c\u8bf7\u8bbf\u95ee&nbsp;Kinnate.com \u5e76\u5173\u6ce8\u5176LinkedIn\u4e3b\u9875\uff0c\u4e86\u89e3\u5176\u6700\u65b0\u4e3e\u63aa\u3002<\/p>\n<p><b>\u5173\u4e8e\u76ae\u5c14\u6cd5\u4f2f<\/b><\/p>\n<p>\u76ae\u5c14\u6cd5\u4f2f\u662f\u6cd5\u56fd\u9886\u5148\u7684\u5236\u836f\u4e0e\u5316\u5986\u54c1\u4f01\u4e1a\uff0c\u5728\u80bf\u7624\u5b66\u9886\u57df\u62e5\u670940\u5e74\u7684\u521b\u65b0\u3001\u5f00\u53d1\u3001\u5236\u9020\u548c\u5546\u4e1a\u5316\u7ecf\u9a8c\u3002\u8be5\u516c\u53f82022\u5e74\u7ea680%\u7684\u7814\u53d1\u652f\u51fa\u7528\u4e8e\u80bf\u7624\u5b66\uff0c\u5e76\u5c06\u9776\u5411\u7597\u6cd5\u786e\u5b9a\u4e3a\u5176\u4e3b\u8981\u7814\u53d1\u91cd\u70b9\u3002\u5176\u76ee\u524d\u7684\u80bf\u7624\u5b66\u5546\u4e1a\u4ea7\u54c1\u7ec4\u5408\u6db5\u76d6\u7ed3\u76f4\u80a0\u764c\u3001\u4e73\u817a\u764c\u3001\u80ba\u764c\u3001\u9ed1\u8272\u7d20\u7624\u3001\u8840\u6db2\u5b66\u75be\u75c5\u548c\u764c\u524d\u76ae\u80a4\u75c5\uff08\u5982\u5149\u5316\u6027\u89d2\u5316\u75c5\uff09\u3002<\/p>\n<p>2022\u5e74\uff0c\u76ae\u5c14\u6cd5\u4f2f\u8425\u4e1a\u989d\u8fbe27\u4ebf\u6b27\u5143\uff0c\u5176\u4e2d69%\u6765\u81ea\u4e8e\u5728120\u4e2a\u56fd\u5bb6\u3001\u5730\u533a\u7684\u56fd\u9645\u9500\u552e\u3002\u81ea1962\u5e74\u521b\u7acb\u4ee5\u6765\uff0c\u8be5\u96c6\u56e2\u603b\u90e8\u4f4d\u4e8e\u6cd5\u56fd\u897f\u5357\u90e8\uff0c\u8d85\u8fc790%\u7684\u4ea7\u54c1\u5728\u6cd5\u56fd\u5883\u5185\u751f\u4ea7\uff0c\u5168\u7403\u8303\u56f4\u5185\u62e5\u6709\u7ea69600\u540d\u5458\u5de5\u3002\u8be5\u516c\u53f886%\u7684\u80a1\u4efd\u7531\u653f\u5e9c\u8ba4\u53ef\u7684\u516c\u76ca\u57fa\u91d1\u4f1a\u76ae\u5c14\u6cd5\u4f2f\u57fa\u91d1\u4f1a\u6301\u6709\uff0c\u5176\u6b21\u901a\u8fc7\u56fd\u9645\u5458\u5de5\u6301\u80a1\u8ba1\u5212\u7531\u5176\u81ea\u6709\u5458\u5de5\u6301\u6709\u3002\u76ae\u5c14\u6cd5\u4f2f\u7684\u53ef\u6301\u7eed\u53d1\u5c55\u653f\u7b56\u7ecf\u72ec\u7acb\u7684AFNOR\u8ba4\u8bc1\u673a\u6784\u8bc4\u4f30\uff0c\u8fbe\u5230\u4e86\u5176\u4f01\u4e1a\u793e\u4f1a\u8d23\u4efb\uff08CSR\uff09\u6807\u7b7e\u7684&quot;\u5178\u8303&quot;\u6c34\u5e73\uff08ISO 26 000\u53ef\u6301\u7eed\u53d1\u5c55\u6807\u51c6\uff09\u3002<\/p>\n<p>\u5982\u9700\u4e86\u89e3\u66f4\u591a\u6709\u5173\u76ae\u5c14\u6cd5\u4f2f\u7684\u4fe1\u606f\uff0c\u8bf7\u8bbf\u95ee<span id=\"spanHghlt5a4a\"><a href=\"https:\/\/www.pierre-fabre.com\/en-us\" target=\"_blank\" rel=\"nofollow noopener\">www.pierre-fabre.com<\/a><a href=\"https:\/\/www.pierre-fabre.com\/en-us\" target=\"_blank\" rel=\"nofollow noopener\">@PierreFabre<\/a><\/span>\u3002<\/p>\n<p><b>\u5176\u4ed6\u91cd\u8981\u4fe1\u606f\u53ca\u4fe1\u606f\u67e5\u627e\u9014\u5f84<\/b><\/p>\n<p>\u4e3a\u914d\u5408\u5bf9&nbsp;Kinnate \u7684\u62df\u8bae\u6536\u8d2d\uff0cXOMA \u6216\u5176\u5173\u8054\u516c\u53f8\u5c06\u6839\u636e\u622a\u81f3&nbsp;2024 \u5e74&nbsp;2 \u6708&nbsp;16 \u65e5&nbsp;\u7684\u300a\u5408\u5e76\u534f\u8bae\u548c\u8ba1\u5212\u300b\uff08&quot;\u5408\u5e76\u534f\u8bae&quot;\uff09\u6761\u6b3e\uff0c\u542f\u52a8\u9488\u5bf9&nbsp;Kinnate 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\u7684\u5f81\u6c42\u610f\u89c1\/\u5efa\u8bae\u58f0\u660e\u3002\u8d2d\u4e70\u516c\u53f8\u6d41\u901a\u80a1\u7684\u8981\u7ea6\u6536\u8d2d\u4ec5\u80fd\u6839\u636e\u4f5c\u4e3a\u6536\u8d2d\u8981\u7ea6\u8868\u4e00\u90e8\u5206\u63d0\u4ea4\u7684\u8d2d\u4e70\u8981\u7ea6\u3001\u8f6c\u6587\u51fd\u53ca\u76f8\u5173\u6587\u4ef6\u8fdb\u884c\u3002<b>\u6295\u8d44\u8005\u548c\u8bc1\u5238\u6301\u6709\u4eba\u52a1\u5fc5\u9605\u8bfb\u8981\u7ea6\u6750\u6599\uff08\u5305\u62ec\u8d2d\u4e70\u8981\u7ea6\u3001\u8f6c\u6587\u51fd\u53ca\u76f8\u5173\u6587\u4ef6\uff09\u548c\u6709\u5173\u8981\u7ea6\u7684\u9644\u8868<\/b><b>&nbsp;14D-9 <\/b><b>\u5f81\u6c42\u610f\u89c1<\/b><b>\/<\/b><b>\u5efa\u8bae\u58f0\u660e\uff0c\u56e0\u4e3a\u8fd9\u4e9b\u6750\u6599\u5305\u542b\u8981\u7ea6\u6761\u6b3e\u548c\u6761\u4ef6\u7b49\u91cd\u8981\u4fe1\u606f\uff0c\u6295\u8d44\u8005\u548c\u8bc1\u5238\u6301\u6709\u4eba\u5728\u5c31\u8981\u7ea6\u505a\u51fa\u4efb\u4f55\u51b3\u5b9a\u4e4b\u524d\u5e94\u4f5c\u8003\u8651\uff0c\u4e14\u8fd9\u4e9b\u6750\u6599\u53ef\u80fd\u4f1a\u968f\u65f6\u8fdb\u884c\u4fee\u8ba2\u6216\u8865\u5145\u3002<\/b>\u6295\u8d44\u8005\u548c\u8bc1\u5238\u6301\u6709\u4eba\u53ef\u4ee5\u5728\u7f8e\u56fd\u8bc1\u5238\u4ea4\u6613\u59d4\u5458\u4f1a\uff08SEC\uff09\u7684\u7f51\u7ad9 <a href=\"https:\/\/www.sec.gov\/\" target=\"_blank\" rel=\"nofollow noopener\">www.sec.gov<\/a> \u4e0a\u83b7\u53d6\u8fd9\u4e9b\u58f0\u660e\uff08\u5982\u6709\uff09\uff0c\u4ee5\u53ca\u5176\u4ed6\u63d0\u4ea4\u7ed9 SEC \u7684\u6587\u4ef6\u7684\u514d\u8d39\u526f\u672c\uff0c\u6216\u5c06\u6b64\u7c7b\u8bf7\u6c42\u63d0\u4ea4\u81f3\u8981\u7ea6\u58f0\u660e\u4e2d\u6307\u5b9a\u7684\u8981\u7ea6\u4fe1\u606f\u4ee3\u7406\u3002\u6295\u8d44\u8005\u548c\u8bc1\u5238\u6301\u6709\u4eba\u8fd8\u53ef\u4ee5\u514d\u8d39\u83b7\u53d6\u516c\u53f8\u63d0\u4ea4\u6216\u63d0\u4f9b\u7ed9 SEC \u7684\u6587\u4ef6\u3002\u6587\u4ef6\u53ef\u5728\u516c\u53f8\u7f51\u7ad9<a href=\"https:\/\/investors.kinnate.com\/\" target=\"_blank\" rel=\"nofollow noopener\">https:\/\/investors.kinnate.com\/ &quot;Financial Information<\/a>\uff08\u8d22\u52a1\u4fe1\u606f\uff09\u680f\u7684 &quot;SEC Filings\uff08SEC \u6587\u4ef6\uff09&quot; \u5b50\u680f\u76ee\u4e2d\u627e\u5230\u3002<\/p>\n<p><b>\u5173\u4e8e\u524d\u77bb\u6027\u9648\u8ff0\u7684\u8b66\u793a\u6027\u8bf4\u660e<\/b><\/p>\n<p>\u672c\u901a\u8baf\u5305\u542b\u524d\u77bb\u6027\u9648\u8ff0\uff0c\u5305\u62ec\u4f46\u4e0d\u9650\u4e8e\u4ee5\u4e0b\u5185\u5bb9\uff1a\u8be5\u4ea4\u6613\u5bf9\u76ae\u5c14\u6cd5\u4f2f\u672a\u6765\u6d3b\u52a8\u7684\u672a\u6765\u5f71\u54cd\uff1b\u516c\u53f8\u9996\u5e2d\u6267\u884c\u5b98\u548c\u76ae\u5c14\u6cd5\u4f2f\u533b\u7597\u4fdd\u5065\u7814\u53d1\u4e3b\u7ba1\u7684\u9648\u8ff0\uff1b\u516c\u53f8\u6839\u636e APA \u6536\u5230\u7684\u5bf9\u4ef7\uff1b\u76ae\u5c14\u6cd5\u4f2f\u6839\u636e APA \u9700\u627f\u62c5\u7684\u8d1f\u503a\uff1b\u516c\u53f8\u5bf9CRV\u534f\u8bae\u7684\u4fe1\u5ff5\u3001\u671f\u671b\u53ca\u58f0\u660e\uff1b\u6839\u636e APA \u548c CVR \u534f\u8bae\uff0c\u53ef\u80fd\u5411\u516c\u53f8\u80a1\u4e1c\u652f\u4ed8\u7684\u6536\u76ca\uff08\u5982\u6709\uff09\uff0c\u5305\u62ec APA \u534f\u8bae\u4e0b <span id=\"spanHghlt294d\">Exarafenib<\/span> \u6216\u4efb\u4f55\u5176\u4ed6\u6cdb RAF \u8d44\u4ea7\u76f8\u5173\u7684\u4efb\u4f55\u51c0\u6536\u76ca\u6216\u6216\u6709\u4ed8\u6b3e\u3002\u8fd9\u4e9b\u9648\u8ff0\u53ef\u4ee5\u901a\u8fc7\u524d\u77bb\u6027\u672f\u8bed\u7684\u4f7f\u7528\u8fdb\u884c\u8bc6\u522b\uff0c\u5305\u62ec\u4f46\u4e0d\u9650\u4e8e&quot;\u9884\u671f&quot;\u3001&quot;\u76f8\u4fe1&quot;\u3001&quot;\u7ee7\u7eed&quot;\u3001&quot;\u53ef\u4ee5&quot;\u3001&quot;\u4f30\u8ba1&quot;\u3001&quot;\u671f\u671b&quot;\u3001&quot;\u76ee\u6807&quot;\u3001&quot;\u6253\u7b97&quot; 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\u548c\u5176\u4ed6\u6cdb&nbsp;RAF \u9879\u76ee\u8d44\u4ea7\u7684\u5168\u7403\u6743\u5229\u7b7e\u8ba2\u8d44\u4ea7\u8d2d\u4e70\u534f\u8bae\uff08&quot;APA&quot;\uff09\u3002 \u8be5\u4ea4\u6613\u65e8\u5728\u63a8\u8fdb&nbsp;Kinnate \u6b64\u524d\u5ba3\u5e03\u7684\u6218\u7565\u5907\u9009\u65b9\u6848\u3002 \u6b64\u6b21\u6536\u8d2d\u610f\u5728\u8fdb\u4e00\u6b65\u5f3a\u5316\u76ae\u5c14\u6cd5\u4f2f\u5728\u7cbe\u51c6\u80bf\u7624\u5b66\u9886\u57df\u7684\u52aa\u529b\uff0c\u5e76\u6709\u673a\u4f1a\u60e0\u53ca\u66f4\u591a\u9700\u8981\u9776\u5411\u6cbb\u7597\u7684&nbsp;RAF \u548c RAS \u5b9e\u4f53\u7624\u60a3\u8005\u3002 \u65e7\u91d1\u5c71\u3001\u5723\u5730\u4e9a\u54e5\u548c\u6cd5\u56fd\u5361\u65af\u7279\u5c142024\u5e744\u67082\u65e5 \/\u7f8e\u901a\u793e\/ &#8212;&nbsp;\u4e34\u5e8a\u9636\u6bb5\u7cbe\u51c6\u80bf\u7624\u5b66\u516c\u53f8 Kinnate \u751f\u7269\u5236\u836f\u516c\u53f8\uff08\u7eb3\u65af\u8fbe\u514b\u80a1\u7968\u4ee3\u7801\uff1aKNTE\uff09\uff08\u4ee5\u4e0b\u7b80\u79f0&quot;Kinnate&quot;\u6216&quot;\u8be5\u516c\u53f8&quot;\uff09\u4e0e\u5168\u7403\u9886\u5148\u7684\u80bf\u7624\u5b66\u516c\u53f8\u2014\u2014\u76ae\u5c14\u6cd5\u4f2f\u96c6\u56e2\u8fd1\u65e5\u5ba3\u5e03\uff0c\u53cc\u65b9\u540c\u610f\u7b7e\u8ba2\u8d44\u4ea7\u8d2d\u4e70\u534f\u8bae\u3002\u6839\u636e\u534f\u8bae\uff0cKinnate\u540c\u610f\u5411\u76ae\u5c14\u6cd5\u4f2f\u51fa\u552e\u8be5\u516c\u53f8\u5728\u7814\u7684\u6cdb RAF \u6291\u5236\u5242 Exarafenib \u548c\u5176\u4ed6\u6cdb RAF \u9879\u76ee\u8d44\u4ea7\u3002\u6b64\u6b21\u5168\u7403\u6743\u5229\u51fa\u552e\u662f\u4e3a\u4e86\u8fdb\u4e00\u6b65\u63a8\u8fdbKinnate\u5148\u524d\u5ba3\u5e03\u7684\u6218\u7565\u5907\u9009\u65b9\u6848\u65b9\u9762\u7684\u63a2\u7d22\u3002 Kinnate \u9996\u5e2d\u6267\u884c\u5b98&nbsp;Nima Farzan \u8868\u793a\uff1a&quot;\u6211\u4eec\u5f88\u9ad8\u5174\u80fd\u4e0e\u76ae\u5c14\u6cd5\u4f2f\u5408\u4f5c\uff0c\u4ed6\u4eec\u5728&nbsp;RAF \u548c&nbsp;RAS \u9a71\u52a8\u5b9e\u4f53\u7624\u9776\u5411\u6cbb\u7597\u7684\u5168\u7403\u5f00\u53d1\u548c\u5546\u4e1a\u5316\u65b9\u9762\u62e5\u6709\u4e30\u5bcc\u7684\u4e13\u4e1a\u77e5\u8bc6\u3002\u5c06&nbsp;Exarafenib \u548c\u6211\u4eec\u7684\u6cdb&nbsp;RAF \u9879\u76ee\u8d44\u4ea7\u51fa\u552e\u7ed9\u76ae\u5c14\u6cd5\u4f2f\u5c06\u6269\u5927\u8fd9\u4e9b\u9879\u76ee\u5728\u5168\u7403\u7684\u5f71\u54cd\u8303\u56f4\uff0c\u4f7f&nbsp;NRAS \u9a71\u52a8\u9ed1\u8272\u7d20\u7624\u548c&nbsp;BRAF \u9a71\u52a8\u5b9e\u4f53\u7624\u9776\u5411\u6cbb\u7597\u6709\u671b\u5f97\u5230\u8fdb\u4e00\u6b65\u53d1\u5c55\uff0c\u6709\u52a9\u5b9e\u73b0\u6211\u4eec\u5bf9\u6b64\u7c7b\u80bf\u7624\u60a3\u8005\u7684\u627f\u8bfa\u3002&quot; \u76ae\u5c14\u6cd5\u4f2f\u5236\u836f\u7814\u53d1\u8d1f\u8d23\u4eba&nbsp;Francesco Hofmann 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\u7684\u8865\u5145\u3002\u6b64\u6b21\u6536\u8d2d\u5c06\u7ee7\u7eed\u63a8\u8fdb\u6211\u4eec\u5728\u7cbe\u51c6\u80bf\u7624\u5b66\u9886\u57df\u7684\u52aa\u529b\uff0c\u5e76\u4e3a\u6211\u4eec\u63d0\u4f9b\u4e86\u673a\u4f1a\u60e0\u53ca\u66f4\u591a\u6709&nbsp;RAF \u548c&nbsp;RAS \u5b9e\u4f53\u7624\u6cbb\u7597\u9700\u6c42\u7684\u60a3\u8005\u3002&quot; \u6839\u636e&nbsp;APA \u6761\u6b3e\uff0c\u76ae\u5c14\u6cd5\u4f2f\u5df2\u8d2d\u4e70&nbsp;Exarafenib \u548c\u5176\u4ed6\u6cdb&nbsp;RAF \u8d44\u4ea7\uff0c\u5e76\u5c06\u627f\u62c5\u4e0e\u8fd9\u4e9b\u8d44\u4ea7\u76f8\u5173\u7684\u5168\u90e8\u8fdb\u884c\u4e2d\u9879\u76ee\u548c\u6210\u672c\u3002Kinnate \u5c06\u83b7\u5f97\u9ad8\u8fbe&nbsp;3100 \u4e07\u7f8e\u5143\u7684\u603b\u5bf9\u4ef7\uff0c\u5176\u4e2d\u5305\u62ec\u4ea4\u5272\u65f6\u7684&nbsp;50 \u4e07\u7f8e\u5143\u4ee5\u53ca\u4e00\u7b14&nbsp;3050 \u4e07\u7f8e\u5143\u7684\u4ed8\u6b3e\uff0c\u4ed8\u6b3e\u6761\u4ef6\u4e3a\uff1a&nbsp;Exarafenib 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More<\/a><\/p>\n","protected":false},"author":556,"featured_media":0,"comment_status":"close","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1965],"tags":[],"class_list":["post-109903","post","type-post","status-publish","format-standard","hentry","category-partnerships"],"amp_enabled":true,"_links":{"self":[{"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/posts\/109903","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/users\/556"}],"replies":[{"embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/comments?post=109903"}],"version-history":[{"count":1,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/posts\/109903\/revisions"}],"predecessor-version":[{"id":109904,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/posts\/109903\/revisions\/109904"}],"wp:attachment":[{"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/media?parent=109903"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/categories?post=109903"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/tags?post=109903"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}