{"id":109698,"date":"2024-04-01T15:18:00","date_gmt":"2024-04-01T08:18:00","guid":{"rendered":"https:\/\/www.xinwengao.com\/cn\/pr\/20240401151800109698"},"modified":"2024-04-01T21:22:49","modified_gmt":"2024-04-01T13:22:49","slug":"%e5%a4%a9%e6%bc%94%e8%8d%af%e4%b8%9a%e5%85%ac%e5%b8%832023%e5%b9%b4%e5%85%a8%e5%b9%b4%e8%b4%a2%e5%8a%a1%e4%b8%9a%e7%bb%a9%e5%8f%8a%e5%85%ac%e5%8f%b8%e8%bf%9b%e5%b1%95","status":"publish","type":"post","link":"https:\/\/www.xinwengao.com\/cn\/pr\/20240401151800109698","title":{"rendered":"\u5929\u6f14\u836f\u4e1a\u516c\u5e032023\u5e74\u5168\u5e74\u8d22\u52a1\u4e1a\u7ee9\u53ca\u516c\u53f8\u8fdb\u5c55"},"content":{"rendered":"<p class=\"prntac\">-\u63a9\u853d\u578b\u6297CTLA-4\u5b89\u5168\u6297\u4f53SAFEbody&reg; 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mg\/kg\u7684\u5242\u91cf\u8303\u56f4\u5185\u5bf9\u7ecf\u8fc7\u5927\u91cf\u591a\u7ebf\u6cbb\u7597\u7684\u665a\u671f\/\u8f6c\u79fb\u6027\u60a3\u8005\uff08N=46\uff09\u5177\u6709\u5dee\u5f02\u5316\u7684\u5b89\u5168\u6027\uff1a\n<ul type=\"disc\">\n<li>\u89c2\u5bdf\u5230\u6709\u9650\u7684\u5242\u91cf\u4f9d\u8d56\u6027\u6bd2\u6027\u3002<\/li>\n<li>46\u540d\u60a3\u8005\u4e2d\uff0c5\u540d\uff0810.8%\uff09\u51fa\u73b03\u7ea7\u6cbb\u7597\u76f8\u5173\u4e0d\u826f\u4e8b\u4ef6\uff08TRAE\uff09\uff0c\u672a\u51fa\u73b04\u7ea7\u4e0e5\u7ea7\u6cbb\u7597\u76f8\u5173\u4e0d\u826f\u4e8b\u4ef6\uff0c\u4e2d\u65ad\u7387\u4e3a6.5%\uff083\/46\uff09\u3002<\/li>\n<\/ul>\n<\/li>\n<li>\u5728\u9488\u5bf9\u4e0d\u540c\u80bf\u7624\u7c7b\u578b\u7684\u5242\u91cf\u9012\u589e\u8bd5\u9a8c\u4e2d\uff0c\u4ece3\u540d\u63a5\u53d7\u5242\u91cf\u6c34\u5e73\u4e3a10 mg\/kg\u4e14\u6bcf3\u5468\u7ed9\u836f\u7684ADG126\u6cbb\u7597\u7684\u60a3\u8005\u8eab\u4e0a\u89c2\u5bdf\u5230\u4e24\u4f8b\u786e\u8ba4\u7684\u90e8\u5206\u7f13\u89e3\uff08PR\uff09\uff0c\u5176\u4e2d\u4e00\u540d\u4e3a\u7ecfPD-1\u6cbb\u7597\u8010\u836f\u7684\u5bab\u9888\u764c\u60a3\u8005\uff0c\u53e6\u4e00\u540d\u5b50\u5bab\u5185\u819c\u764c\u60a3\u8005\u3002\u7531\u6b64\u542f\u52a8\u8be5\u7ed9\u836f\u65b9\u6848\u7684\u6269\u5c55\u961f\u5217\u3002\u4e24\u4f8b\u5df2\u786e\u8ba4\u7684\u90e8\u5206\u80bf\u7624\u7f13\u89e3\u5df2\u6301\u7eed\u8d85\u8fc7\u4e00\u5e74\uff0c\u540c\u65f6\u6cbb\u7597\u65b9\u6848\u663e\u793a\u4e86\u4f18\u5f02\u7684\u5b89\u5168\u6027\u3002<\/li>\n<li>\u5728\u9488\u5bf9MSS CRC\u7684\u5242\u91cf\u6269\u5c55\u8bd5\u9a8c\u4e2d\uff0c12\u540d\u65e0\u809d\u8f6c\u79fb\u7684\u53ef\u8bc4\u4f30\u60a3\u8005\u63a5\u53d7\u5242\u91cf\u6c34\u5e73\u4e3a10 mg\/kg\u4e14\u6bcf3\u5468\u7ed9\u836f\u7684\u5f3a\u6548\u6cbb\u7597\uff1b\n<ul type=\"disc\">\n<li>\u4ece\u5176\u4e2d9\u540d\u65e0\u8179\u819c\u548c\u809d\u8f6c\u79fb\u7684\u60a3\u8005\u8eab\u4e0a\u89c2\u5bdf\u5230\u4e24\u4f8b\u786e\u8ba4\u7684\u90e8\u5206\u7f13\u89e3\uff0c\u8be5\u7ec4\u60a3\u8005\u7684\u603b\u7f13\u89e3\u7387\u4e3a22%\u3002<\/li>\n<li>\u8fd99\u540d\u60a3\u8005\u4e2d\u67097\u540d\u51fa\u73b0\u75c5\u60c5\u7a33\u5b9a\uff08SD\uff09\uff0c\u603b\u75be\u75c5\u63a7\u5236\u7387100%\uff082\u4f8b\u90e8\u5206\u7f13\u89e3\uff0c7\u4f8b\u75c5\u60c5\u7a33\u5b9a\uff09\u3002<\/li>\n<li>\u6839\u636eSimon\u7684\u4e24\u9636\u6bb5\u8bbe\u8ba1\uff0c\u57fa\u4e8e\u4e34\u5e8a\u7ed3\u679c\u5c06\u8be5\u5242\u91cf\u6c34\u5e73\u7684\u8bd5\u9a8c\u8ba1\u5212\u63a8\u8fdb\u81f3\u7b2c\u4e8c\u9636\u6bb5\u3002<\/li>\n<\/ul>\n<\/li>\n<li>\u5728\u5bf9\u8fd9\u4e9b\u65e0\u809d\u548c\u8179\u819c\u8f6c\u79fb\u7684MSS CRC\u60a3\u8005\u7684\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff08PFS\uff09\u521d\u6b65\u5206\u6790\u4e2d\uff0c\u63a5\u53d710 mg\/kg\u4e24\u4e2a\u7ed9\u836f\u9891\u7387\uff08\u6bcf3\u5468\u7ed9\u836f\uff08n=9\uff09\u548c\u6bcf6\u5468\u7ed9\u836f\u4e00\u6b21\uff08n=6\uff09\uff09\u7684ADG126\u6cbb\u7597\u7684\u60a3\u8005\u7684PFS\u4e2d\u4f4d\u6570\u4e3a7\u4e2a\u6708\u3002\u968f\u7740\u4e00\u4e2a\u66f4\u5927\u578b\u7684\u60a3\u8005\u961f\u5217\u572810 mg\/kg\u3001\u6bcf3\u5468\u7ed9\u836f\u8bd5\u9a8c\u4e2d\u63a5\u53d7\u8bc4\u4f30\uff0cADG126\u8054\u5408\u5e15\u535a\u5229\u73e0\u5355\u6297\u7684\u6301\u4e45\u4e34\u5e8a\u7597\u6548\u5c06\u5f97\u5230\u8fdb\u4e00\u6b65\u68c0\u9a8c\u3002<\/li>\n<li>\u7f8e\u56fd\u4e34\u5e8a\u80bf\u7624\u5b66\u4f1a\u80c3\u80a0\u9053\u764c\u75c7\u7814\u8ba8\u4f1a\u540e\uff0c\u5929\u6f14\u516c\u5e03\u4e86ADG126\u4e34\u5e8a\u8bd5\u9a8c\u9879\u76ee\u7684\u8fdb\u5c55\u548c\u62d3\u5c55\uff0c\u6b63\u5728\u8fdb\u884c\u76842\u671f\u5242\u91cf\u6269\u5c55\u961f\u5217\u5c06\u6269\u5927\u5230\u8d85\u8fc750\u540dMSS CRC\u60a3\u8005\u3002\u9879\u76ee\u7684\u4e34\u5e8a\u5f00\u53d1\u66f4\u65b0\u5305\u542b\u4ee5\u4e0b\u5185\u5bb9<span id=\"spanHghlt5fad\">\uff1a<\/span>\n<ul type=\"disc\">\n<li>\u516c\u53f8\u5ba3\u5e03\u6b63\u5728\u8fdb\u884c\u7684\u8bc4\u4f30ADG126 10 mg\/kg \u6bcf3\u5468\u4e00\u6b21\u8054\u5408\u5e15\u535a\u5229\u73e0\u5355\u6297\u6cbb\u7597MSS CRC\u76842\u671f\u5242\u91cf\u6269\u5c55\u961f\u5217\u5df2\u57282023\u5e74\u7b2c\u56db\u5b63\u5ea6\u5b8c\u6210\u5904\u4e8eSimon\u4e24\u9636\u6bb5\u8bbe\u8ba1\u7684\u7b2c\u4e8c\u9636\u6bb5\u7684\u989d\u5916\u65b0\u589e\u768412\u540d\u60a3\u8005\u5165\u7ec4\u3002\u4ee5\u4e0a\u7b2c\u4e8c\u9636\u6bb5\u7684\u7ed3\u679c\u6709\u671b\u8fdb\u4e00\u6b65\u9a8c\u8bc1\u8fd1\u671f\u57282024\u5e74\u7f8e\u56fdASCO-GI\u7814\u8ba8\u4f1a\u4e0a\u516c\u5e03\u7684\u8be5\u961f\u5217\u7b2c\u4e00\u9636\u6bb5\u7814\u7a76\u6570\u636e\u3002<\/li>\n<li>\u9274\u4e8eADG126\u7684\u5b89\u5168\u6027\uff0c\u5929\u6f14\u8fd8\u542f\u52a8\u4e86\u9488\u5bf920 mg\/kg\u8d1f\u8377\u5242\u91cf\u4e0bADG126\u8054\u5408\u5e15\u535a\u5229\u73e0\u5355\u6297\u6cbb\u7597\u665a\u671f\/\u8f6c\u79fb\u6027\u764c\u75c7\u60a3\u8005\u7684\u8bc4\u4f30\u3002\u516c\u53f8\u76ee\u524d\u6b63\u5bf9\u8fd9\u4e00\u7ed9\u836f\u65b9\u6848\u8fdb\u884c\u5b89\u5168\u6027\u8bc4\u4f30\uff0c\u5e76\u8ba1\u5212\u5728\u968f\u540e\u5f00\u5c55\u7684\u7f8e\u56fd\u548c\u4e9a\u592a\u5730\u533aMSS CRC\u60a3\u8005\u7684\u6269\u5c55\u961f\u5217\u4e2d\u8bc4\u4f3020 mg\/kg\u8d1f\u8377\u5242\u91cf\u540e10 mg\/kg\u6bcf3\u5468\u4e00\u6b21\u7ef4\u6301\u5242\u91cf\u4e0b\u8054\u5408\u5e15\u535a\u5229\u73e0\u5355\u6297\u6cbb\u7597\u7684\u6709\u6548\u6027\u3002<\/li>\n<li>\u516c\u53f8\u5df2\u83b7\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u836f\u54c1\u5ba1\u8bc4\u4e2d\u5fc3\uff08CDE\uff09\u6279\u51c6\u4e8e\u4e2d\u56fd\u542f\u52a8ADG126\u8054\u5408\u5e15\u535a\u5229\u73e0\u5355\u6297\u7684\u4e34\u5e8a\u8bc4\u4f30\u3002\u8fd9\u5c06\u6709\u5229\u4e8e\u5929\u6f14\u5728\u548c\u9ed8\u6c99\u4e1c\u4e34\u5e8a\u5408\u4f5c\u9879\u76ee\u4e0a\u4e8e\u66f4\u591aMSS CRC\u60a3\u8005\u7fa4\u4f53\u53ca\u6f5c\u5728\u5176\u4ed6\u80bf\u7624\u7c7b\u578b\u4e2d\u8bc4\u4f30\u8be5\u8054\u5408\u7597\u6cd5\u7684\u7597\u6548\u3002<\/li>\n<\/ul>\n<\/li>\n<li>\u6b64\u5916\uff0c\u8fd1\u671f\u516c\u53f8\u5728\u4e2d\u56fd\u5df2\u542f\u52a8\u5f00\u5c55\u9488\u5bf9\u665a\u671f\/\u8f6c\u79fb\u6027\u764c\u75c7\u60a3\u8005\u8fdb\u884c ADG126 30 mg\/kg \u6bcf3\u5468\u4e00\u6b21\u5355\u836f\u6cbb\u7597\u8bc4\u4f30\uff0c\u4ee5\u786e\u5b9a ADG126 \u5355\u836f\u6cbb\u7597\u7684\u6f5c\u5728\u6700\u5927\u8010\u53d7\u5242\u91cf\u3002<\/li>\n<\/ul>\n<\/li>\n<li><b><i>Ib\/2<\/i><\/b>\u671f\u6570\u636e\u8868\u660e\uff0c\u9776\u5411\u72ec\u7279\u8868\u4f4d\u7684\u6297<b><i>CTLA-4<\/i><\/b>\u975e\u63a9\u853d\u578b\u65b0\u8868\u4f4d\u6297\u4f53<b><i>NEObody&#x2122; ADG116<\/i><\/b>\u5728\u5355\u4e00\u7597\u6cd5\u4ee5\u53ca\u4e0e\u6297<b><i>PD-1<\/i><\/b>\u7684\u8054\u5408\u7597\u6cd5\u4e2d\u5747\u663e\u793a\u51fa\u826f\u597d\u7684\u5b89\u5168\u6027\u4e0e\u4e34\u5e8a\u7f13\u89e3\u3002\n<ul type=\"disc\">\n<li>ADG116\u5355\u4e00\u7597\u6cd5\u5728\u6700\u9ad8\u5242\u91cf\u8fbe\u523015mg \/kg\uff08N=59\uff09\u7684\u8bd5\u9a8c\u4e2d\u663e\u793a\u51fa\u826f\u597d\u7684\u5b89\u5168\u6027\uff0c\u5e76\u4e14\u5176\u603b\u7f13\u89e3\u7387\uff08ORR\uff09\u8fbe\u523013%\uff083\/23\u53ef\u8bc4\u4f30\uff09\uff0c\u5305\u62ec\u5728\u591a\u4e2a\u4e0d\u540c\u80bf\u7624\u7c7b\u578b\u7684\u60a3\u8005\u4e2d\u89c2\u5bdf\u5230\u786e\u8ba4\u7684\u6301\u4e45\u80bf\u7624\u7f13\u89e3\u3002<\/li>\n<li>\u4e0e\u6297PD-1\u7597\u6cd5\uff08N=22\uff09\u7684\u8054\u5408\u6cbb\u7597\u8bd5\u9a8c\u7ed3\u679c\u8868\u660e\uff0c\u5728\u5242\u91cf\u6c34\u5e73\u4e3a3 mg\/kg\u4e14\u6bcf6\u5468\u7ed9\u836f\u4e00\u6b21\u7684\u5242\u91cf\u9012\u589e\u8bd5\u9a8c\u4e2d\uff0cADG116\u5c55\u73b0\u51fa\u53ef\u63a7\u7684\u5b89\u5168\u6027\u4e0e\u4ee4\u4eba\u9f13\u821e\u7684\u6709\u6548\u6027\u3002\u6b63\u5728\u8fdb\u884c\u7684\u8054\u5408\u6cbb\u7597\u961f\u5217\u4e2d\u89c2\u5bdf\u5230\u4e34\u5e8a\u7f13\u89e3\uff0c\u5176\u4e2d\uff0c\u4e00\u4f4d\u5934\u9888\u90e8\u9cde\u72b6\u7ec6\u80de\u764c\uff08HNSCC\uff09\u60a3\u8005\u5728\u5242\u91cf\u6c34\u5e73\u4e3a3mg \/kg\uff08\u6700\u521d\u6bcf3\u5468\u7ed9\u836f\u4e00\u6b21\uff0c\u7136\u540e\u6bcf6\u5468\u7ed9\u836f\u4e00\u6b21\uff09\u7684ADG116\u4e0e\u7279\u745e\u666e\u5229\u5355\u6297\u8054\u5408\u6cbb\u7597\u7684\u91cd\u590d\u7ed9\u836f\u8bd5\u9a8c\u4e2d\u89c2\u5bdf\u5230\u6301\u7eed\u8fd1\u4e24\u5e74\u7684\u6301\u4e45\u5b8c\u5168\u7f13\u89e3\uff08CR\uff09\uff08ORR = 20%\uff1b1\/5\u53ef\u8bc4\u4f30\uff09\u3002\u6b64\u5916\uff0c\u4e00\u4f4dMSS CRC\u60a3\u8005\u5728ADG116\uff08\u5242\u91cf\u6c34\u5e73\u4e3a3mg \/kg\uff0c\u6bcf6\u5468\u7ed9\u836f\u4e00\u6b21\uff09\u4e0e\u7279\u745e\u666e\u5229\u5355\u6297\u8054\u5408\u6cbb\u7597\u7684\u91cd\u590d\u7ed9\u836f\u8bd5\u9a8c\u4e2d\u89c2\u5bdf\u5230\u521d\u6b65\u90e8\u5206\u7f13\u89e3\uff0c\u8fdb\u4e00\u6b65\u9a8c\u8bc1\u4e0e\u9776\u5411\u72ec\u7279\u7684CTLA-4\u8868\u4f4d\u6709\u5173\u7684\u4e34\u5e8a\u6548\u76ca\u548c\u8c03\u8282\u6027T\u7ec6\u80de\u6e05\u9664\u5bf9\u7597\u6548\u7684\u5173\u952e\u610f\u4e49\u3002<\/li>\n<li>ADG116\u5df2\u89c2\u5bdf\u5230\u4e34\u5e8a\u7597\u6548\uff0c\u5e76\u51c6\u5907\u5728\u5408\u7406\u914d\u5907\u8d44\u6e90\u540e\u8fdb\u5165\u66f4\u6df1\u5165\u7684\u4e34\u5e8a\u5f00\u53d1\u3002<\/li>\n<\/ul>\n<\/li>\n<li>\u7ecf\u8fc7&nbsp;Fc \u7aef\u4f18\u5316\u7684\u6297 CD137 IgG1 \u63a9\u853d\u578bPOWERbody<sup>TM<\/sup>\u5f3a\u529b\u6297\u4f53ADG206\u9488\u5bf9\u665a\u671f\/\u8f6c\u79fb\u6027\u80bf\u7624\u60a3\u8005\u7684\u4e34\u5e8aI\u671f\u6b63\u5728\u8fdb\u884c\u4e2d\uff1a\n<ul type=\"disc\">\n<li>\u6b63\u5728\u8fdb\u884c\u7684 1 \u671f\u4e34\u5e8a\u8bd5\u9a8c\u5df2\u62db\u52df 10\u540d\u60a3\u8005\uff0c\u4ee5\u8bc4\u4f30\u65b0\u4e00\u4ee3\u6297 CD137 \u5019\u9009\u836f\u7269\u7684\u5b89\u5168\u6027\u3001\u6709\u6548\u6027\u548c\u8010\u53d7\u6027\u3002\u76ee\u524d\u6b63\u5728\u5f00\u5c55\u5242\u91cf\u6c34\u5e73\u4e3a3 mg\/kg\u4e14\u6bcf3\u5468\u7ed9\u836f\u4e00\u6b21\u7684\u5242\u91cf\u9012\u589e\u8bd5\u9a8c\u3002\u5c1a\u672a\u8fbe\u5230\u6700\u5927\u8010\u53d7\u5242\u91cf\uff08MTD\uff09\u3002<\/li>\n<li>\u4e34\u5e8a\u524d\u6570\u636e\u8868\u660e\uff0cADG206\u5728\u591a\u79cd\u80bf\u7624\u6a21\u578b\u7684\u5355\u836f\u6cbb\u7597\u4e2d\u5177\u6709\u826f\u597d\u7684\u8010\u53d7\u6027\u4e0e\u7a33\u5b9a\u7684\u6297\u80bf\u7624\u6d3b\u6027\uff0c\u5728\u6700\u5927\u8010\u53d7\u5242\u91cf\u4e3a 0.1 mg\/kg\u6bcf\u4e09\u5468\u4e00\u6b21\u7ed9\u836f\u65f6\uff0c\u6fc0\u6d3b\u6297\u4f53\u5bf9CD137\u6fc0\u52a8\u578b\u6d3b\u6027\u548cT\u7ec6\u80de\u5171\u523a\u6fc0\u6bd4\u57fa\u51c6\u6297\u4f53\uff08urelumab\u7c7b\u4f3c\u7269\uff09\u5f3a4\u500d\u3002<\/li>\n<li>\u65b0\u4e00\u4ee3\u6297CD137\u5019\u9009\u6297\u4f53ADG206\u662f\u9996\u4e2a\u8fdb\u5165\u4e34\u5e8a\u5f00\u53d1\u9636\u6bb5\u7684\u7ecf\u8fc7Fc\u7aef\u4f18\u5316\u7684\u63a9\u853dPOWERbody&#x2122;\u5f3a\u529b\u6297\u4f53\u5019\u9009\u836f\u7269\uff0c\u7ed3\u5408\u516c\u53f8\u7cbe\u51c6\u63a9\u853d\u3001Fc\u7aef\u4f18\u5316\u4e0e\u521b\u65b0\u8868\u4f4d\u6280\u672f\uff0c\u4ee5\u5e94\u5bf9\u6297CD137\u7597\u6cd5\u7684\u5b89\u5168\u6027\u4e0e\u6709\u6548\u6027\u6311\u6218\u3002<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>\u5546\u52a1\u5408\u4f5c<\/p>\n<ul type=\"disc\">\n<li><b>Exelixis<\/b><b>\uff1a<\/b>\u6839\u636e\u53cc\u65b9\u4e3a\u5f00\u53d1\u539f\u521b\u63a9\u853d\u578b\u6297\u4f53\u5076\u8054\u836f\u7269\u800c\u8fbe\u6210\u7684\u6280\u672f\u6388\u6743\u534f\u8bae\uff0c2023\u5e746\u6708\uff0c\u5929\u6f14\u5728\u7b2c\u4e8c\u4e2a\u5408\u4f5c\u9879\u76ee\u4e2d\u6210\u529f\u7b5b\u9009\u5230\u76ee\u6807\u5b89\u5168\u6297\u4f53SAFEbody&reg;\u5019\u9009\u836f\u7269\uff0c\u5e76\u83b7\u5f97\u4e00\u7b14\u6765\u81eaExelixis\u7684300\u4e07\u7f8e\u5143\u91cc\u7a0b\u7891\u4ed8\u6b3e\u3002<\/li>\n<li><b>\u8d5b\u8bfa\u83f2<\/b><b>\uff1a<\/b>\u5929\u6f14\u4e0e\u8d5b\u8bfa\u83f2\u5408\u4f5c\u5f00\u53d1\u53cc\u7279\u5f02\u6027\u548c\u5355\u514b\u9686SAFEbody&reg;\u5019\u9009\u6297\u4f53\uff0c\u5229\u7528\u5929\u6f14\u7684\u5b89\u5168\u6297\u4f53SAFEbody\u7cbe\u51c6\u63a9\u853d\u6280\u672f\u7814\u53d1\u4e34\u5e8a\u524d\u5019\u9009\u6297\u4f53\uff0c\u7531\u8d5b\u8bfa\u83f2\u8fdb\u884c\u5f00\u53d1\u548c\u5546\u4e1a\u5316\u3002\u6b64\u9879\u5408\u4f5c\u4e8e2022\u5e743\u6708\u516c\u5e03\uff0c\u5305\u62ec\u4e00\u7b141750\u4e07\u7f8e\u5143\u7684\u9996\u4ed8\u6b3e\uff0c\u7528\u4e8e\u9996\u5148\u542f\u52a8\u4e24\u4e2a\u9879\u76ee\uff0c\u548c\u4e00\u7b14\u63d0\u540d\u989d\u5916\u4e24\u4e2a\u9879\u76ee\u7684\u9644\u52a0\u8d39\u7528\uff0c\u8fd8\u5305\u62ec\u6700\u9ad8\u53ef\u8fbe25\u4ebf\u7f8e\u5143\u7684\u6f5c\u5728\u91cc\u7a0b\u7891\u4ed8\u6b3e\uff0c\u4ee5\u53ca\u5206\u7ea7\u7279\u8bb8\u6743\u4f7f\u7528\u8d39\u3002<\/li>\n<li><b>\u7f57\u6c0f\uff1a<\/b>\u7f57\u6c0f\u8d5e\u52a9\u5e76\u5f00\u5c55\u4e00\u9879\u8de8\u56fd1b\/2\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u8bc4\u4f30ADG126\u8054\u5408\u963f\u66ff\u5229\u73e0\u5355\u6297\u548c\u8d1d\u4f10\u73e0\u5355\u6297\u4e4b\u4e09\u8054\u514d\u75ab\u7597\u6cd5\u5728\u665a\u671f\u809d\u7ec6\u80de\u764c\uff08HCC\uff09\u7684\u4e00\u7ebf\u6cbb\u7597\u4e2d\u7684\u6548\u7528\u3002\u5929\u6f14\u4fdd\u7559\u5bf9ADG126\u7684\u5168\u7403\u5f00\u53d1\u4e0e\u5546\u4e1a\u5316\u6743\u5229\u3002<\/li>\n<\/ul>\n<p>\u8463\u4e8b\u4f1a\u4eba\u5458\u53d8\u66f4<\/p>\n<p>\u9664\u975e\u53e6\u6709\u8bf4\u660e\uff0c\u4ee5\u4e0b\u5929\u6f14\u8463\u4e8b\u4f1a\u53d8\u52a8\u5c06\u4e8e20-F\u5f62\u5f0f\u76842023\u5e74\u516c\u53f8\u5e74\u5ea6\u62a5\u544a\uff08&quot;2023\u5e74\u62a5&quot;\uff09\u63d0\u4ea4\u540e\u6b63\u5f0f\u751f\u6548\uff1a<\/p>\n<ul type=\"disc\">\n<li>Grawunder\u535a\u58eb\u5c06\u4ee5\u72ec\u7acb\u8463\u4e8b\u7684\u8eab\u4efd\u52a0\u5165\u516c\u53f8\u8463\u4e8b\u4f1a\uff0c\u5e76\u6210\u4e3a\u5ba1\u8ba1\u59d4\u5458\u4f1a\u548c\u6218\u7565\u59d4\u5458\u4f1a\u6210\u5458\u3002Grawunder\u535a\u58eb\u662f\u745e\u58eb\/\u5fb7\u56fd\u8d44\u6df1\u751f\u547d\u79d1\u5b66\u4f01\u4e1a\u5bb6,\u5728\u6cbb\u7597\u6027\u6297\u4f53\u5f00\u53d1\u884c\u4e1a\u62e5\u6709\u8d85\u8fc720\u5e74\u7684\u7ecf\u9a8c\u3002<\/li>\n<li>\u73b0\u72ec\u7acb\u8463\u4e8b\u6731\u529b\u535a\u58eb\u5c06\u6210\u4e3a\u8463\u4e8b\u4f1a\u85aa\u916c\u59d4\u5458\u4f1a\u6210\u5458\u3002<\/li>\n<li>\u5f20\u8000\u6881\u5148\u751f\u3001Mervyn Turner\u535a\u58eb\u4e0e\u8c2d\u6587\u5065\u5148\u751f\u7684\u8463\u4e8b\u4efb\u671f\u5c06\u7ee7\u7eed\u5ef6\u957f\u3002<\/li>\n<li>\u73b0\u72ec\u7acb\u8463\u4e8b\uff0c\u5ba1\u8ba1\u59d4\u5458\u4f1a\u3001\u85aa\u916c\u59d4\u5458\u4f1a\u4e0e\u63d0\u540d\u548c\u516c\u53f8\u6cbb\u7406\u59d4\u5458\u4f1a\u6210\u5458\u5229\u6c11\u535a\u58eb\uff0c\u4ee5\u53ca\u751f\u7269\u4fe1\u606f\u79d1\u6280\u9ad8\u7ea7\u526f\u603b\u88c1\uff0c\u73b0\u8463\u4e8b\u4f1a\u6210\u5458\u674e\u8273\u5973\u58eb\u56e0\u4e2a\u4eba\u539f\u56e0\u5c06\u8f9e\u53bb\u8463\u4e8b\u4f1a\u548c\u76f8\u5173\u59d4\u5458\u4f1a\u6210\u5458\u804c\u52a1\u3002\u674e\u8273\u5973\u58eb\u5c06\u4e8e2024\u5e746\u670815\u65e5\u6b63\u5f0f\u9000\u51fa\u8463\u4e8b\u4f1a\uff0c\u672a\u6765\u5c06\u7ee7\u7eed\u62c5\u4efb\u8463\u4e8b\u4f1a\u89c2\u5bdf\u5458\u3002\u5229\u6c11\u535a\u58eb\u4e0e\u674e\u8273\u5973\u58eb\u5747\u786e\u8ba4\u4e0e\u8463\u4e8b\u4f1a\u4e0d\u5b58\u5728\u5206\u6b67\uff0c\u5173\u4e8e\u4e8c\u4eba\u7684\u9000\u51fa\u6ca1\u6709\u5176\u4ed6\u9700\u8981\u516c\u53f8\u80a1\u4e1c\u5173\u6ce8\u7684\u95ee\u9898\u3002<\/li>\n<\/ul>\n<p>\u516c\u53f8\u8463\u4e8b\u4f1a\u60f3\u501f\u6b64\u673a\u4f1a\u5411\u5229\u6c11\u535a\u58eb\u4e0e\u674e\u8273\u5973\u58eb\u8868\u793a\u771f\u8bda\u7684\u8c22\u610f\uff0c\u611f\u8c22\u4ed6\u4eec\u5728\u4efb\u671f\u5185\u4e3a\u8463\u4e8b\u4f1a\u6240\u505a\u7684\u5b9d\u8d35\u8d21\u732e\u30022023\u5e74\u5e74\u62a5\u5bf9\u65b0\u4efb\u547d\u8463\u4e8b\u7684\u80cc\u666f\u53ca\u59d4\u4efb\u6761\u6b3e\u5747\u6709\u8be6\u7ec6\u4ecb\u7ecd\u3002<\/p>\n<p><b>2024<\/b>\u5e74\u91cc\u7a0b\u7891\u4e0e\u53ef\u6301\u7eed\u81f3<b>2026<\/b>\u5e74\u7684\u73b0\u91d1\u50a8\u5907<\/p>\n<p>\u575a\u6301\u73b0\u6709\u89c4\u5212\uff0c\u4e25\u683c\u7ba1\u63a7\u73b0\u91d1\uff0c\u5929\u6f14\u9884\u8ba1\u516c\u53f8\u8d44\u91d1\u53ef\u652f\u6301\u516c\u53f8\u52302026\u5e74\u7684\u8fd0\u8425\u6d3b\u52a8\uff0c\u5e76\u9884\u671f\u5b9e\u73b0\u4ee5\u4e0b\u91cc\u7a0b\u7891\uff1a<\/p>\n<ul type=\"disc\">\n<li>\u6b63\u5728\u8fdb\u884c\u7684ADG126\u8054\u5408\u5e15\u535a\u5229\u73e0\u5355\u6297\u76841b\/2\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u5305\u62ecMSS CRC\u5242\u91cf\u6269\u5c55\u961f\u5217\u6570\u636e\u9884\u8ba1\u5c06\u57282024\u5e74\u9010\u6b65\u516c\u5e03\uff1a\n<ul type=\"disc\">\n<li>\u7b2c\u4e00\u90e8\u520610 mg\/kg\u3001\u6bcf3\u5468\u7ed9\u836f \uff08n=12\uff09\u548c10mg \/kg\u3001\u6bcf6\u5468\u7ed9\u836f\uff08n=10\uff09\u53ef\u8bc4\u4f30\u60a3\u8005\u7684\u968f\u8bbf\u7814\u7a76\u6570\u636e<\/li>\n<li>\u7b2c\u4e8c\u90e8\u520610 mg\/kg\u3001\u6bcf3\u5468\u7ed9\u836f\uff08n=12\uff09\u7684\u60a3\u8005\u6570\u636e<\/li>\n<li>\u5e94\u7f8e\u56fdFDA Optimus\u8ba1\u5212\u7684\u8981\u6c42\u8bc4\u4f30\u4e0d\u540c\u5242\u91cf\u5305\u62ec20 mg\/kg\u8d1f\u8377\u5242\u91cf\n<ul type=\"disc\">\n<li>\u91cd\u590d\u7ed9\u836f\u7684\u5b89\u5168\u6027\u6570\u636e<\/li>\n<li>MSS CRC\u60a3\u8005\uff08n~10\uff09\u7684\u5242\u91cf\u6269\u5c55\u6570\u636e<\/li>\n<\/ul>\n<\/li>\n<li>\u4e2d\u56fd\u5730\u533a\u7684\u66f4\u591a\u60a3\u8005\u6570\u636e\uff08n\u226510\uff09<\/li>\n<\/ul>\n<\/li>\n<li>\u8fbe\u6210\u66f4\u591a\u6280\u672f\u6388\u6743\u5408\u4f5c\u548c\/\u6216\u91cc\u7a0b\u7891\u3002<\/li>\n<\/ul>\n<p><b>\u8d22\u52a1<\/b><b>\u4eae\u70b9<\/b><\/p>\n<p><u>\u73b0\u91d1\u548c\u73b0\u91d1\u7b49\u4ef7\u7269<\/u><br \/>\u73b0\u91d1\u548c\u73b0\u91d1\u7b49\u4ef7\u72692022\u5e7412\u670831\u65e5\u7ea61.438\u4ebf\u7f8e\u5143\uff0c2023\u5e7412\u670831\u65e5\u7ea61.099\u4ebf\u7f8e\u5143\u3002\u622a\u81f32023\u5e7412\u670831\u65e5\uff0c\u516c\u53f8\u4ece\u4e2d\u56fd\u5883\u5185\u5404\u5546\u4e1a\u94f6\u884c\u83b7\u5f97\u7684\u4eba\u6c11\u5e01\u8d37\u6b3e\u75312022\u5e7412\u670831\u65e5\u76842,780\u4e07\u7f8e\u5143\u51cf\u5c11\u81f32023\u5e7412\u670831\u65e5\u76842,190\u4e07\u7f8e\u5143\u3002\u4ece\u8d37\u6b3e\u4e2d\u6240\u83b7\u5f97\u8d44\u91d1\u4e3b\u8981\u7528\u6765\u652f\u4ed8\u516c\u53f8\u5728\u4e2d\u56fd\u5883\u5185\u4ea7\u751f\u7684\u7814\u53d1\u8d39\u7528\u3002<\/p>\n<p><u>\u51c0\u6536\u5165<\/u><br \/>\u51c0\u6536\u5165\u76f8\u8f83\u4e8e2022\u5e74\u540c\u671f\u7684930\u4e07\u7f8e\u5143\u589e\u52a0\u52302023\u5e7412\u670831\u65e5\u76841,810\u4e07\u7f8e\u5143\u3002\u51c0\u6536\u5165\u540c\u6bd4\u589e\u957f\u7ea695%\u3002\u8be5\u589e\u957f\u5305\u542b\u4e86\u56e0\u516c\u53f8\u5c65\u884c\u4e86\u4e0eExelixis\u548c\u8d5b\u8bfa\u83f2\u5206\u522b\u7b7e\u8ba2\u7684\u6280\u672f\u5408\u4f5c\u548c\u6388\u6743\u534f\u8bae\u4e2d\u7684\u5c65\u7ea6\u4e49\u52a1\u800c\u786e\u8ba4\u7684\u51c0\u6536\u5165\u3002\u51c0\u6536\u5165\u4e5f\u5305\u542b\u4e86\u4e8e2023\u5e746\u6708\u4eceExelixis\u6536\u5230\u7684300\u4e07\u7f8e\u5143\u91cc\u7a0b\u7891\u4ed8\u6b3e\u3002<\/p>\n<p><u>\u7814\u53d1\u8d39\u7528<\/u><br \/>\u7814\u53d1\u8d39\u7528\u76f8\u8f83\u4e8e2022\u5e74\u540c\u671f\u76848,130\u4e07\u7f8e\u5143\u4e0b\u964d\u52302023\u5e7412\u670831\u65e5\u76843,660\u4e07\u7f8e\u5143\u3002\u7814\u53d1\u8d39\u7528\u540c\u6bd4\u4e0b\u964d\u4e86\u7ea655%\u3002\u8be5\u4e0b\u964d\u6e90\u4e8e\u516c\u53f8\u91cd\u70b9\u4f18\u5148\u53d1\u5c55\u9488\u5bf9\u6297CTLA-4\u7684\u5b89\u5168\u6297\u4f53\u7597\u6cd5\u7684ADG126\u4e34\u5e8a\u9879\u76ee\u3002<\/p>\n<p><u>\u7ba1\u7406\u8d39\u7528<\/u><br \/>\u7ba1\u7406\u8d39\u7528\u76f8\u8f83\u4e8e2022\u5e74\u540c\u671f\u76841,190\u4e07\u7f8e\u5143\u4e0b\u964d\u52302023\u5e7412\u670831\u65e5\u7684870\u4e07\u7f8e\u5143\u3002\u7ba1\u7406\u8d39\u7528\u7684\u4e0b\u964d\u4e3b\u8981\u662f\u7531\u4e8e\u6210\u672c\u63a7\u5236\u63aa\u65bd\u6240\u5e26\u6765\u7684\u4eba\u5de5\u53ca\u529e\u516c\u6210\u672c\u7684\u51cf\u5c11\u3002<\/p>\n<p><u>\u5176\u4ed6\u51c0\u8425\u4e1a\u6536\u5165<\/u><br \/>\u622a\u81f32023\u5e7412\u670831\u65e5\u7684\u5176\u4ed6\u51c0\u8425\u4e1a\u6536\u5165\u7ea6350\u4e07\u7f8e\u5143\u3002\u5176\u4ed6\u51c0\u8425\u4e1a\u6536\u5165\u5305\u542b\u4e86\u4ece\u4e00\u5bb6\u5408\u540c\u5236\u9020\u5546\u5904\u83b7\u5f97\u7684\uff0c\u4e0e\u4e00\u4efd\u4e34\u5e8a\u524d\u9879\u76ee\u5916\u5305\u534f\u8bae\u76f8\u5173\u7684\u4e00\u6b21\u6027\u8865\u507f\u6b3e\u3002<\/p>\n<p><u>\u51c0\u4e8f\u635f<\/u><br \/>\u51c0\u4e8f\u635f\u76f8\u8f83\u4e8e2022\u5e74\u540c\u671f\u76848,000\u4e07\u7f8e\u5143\u4e0b\u964d\u52302023\u5e7412\u670831\u65e5\u76841,890\u4e07\u7f8e\u5143\u3002<\/p>\n<p><u>\u6d41\u901a\u5728\u5916\u666e\u901a\u80a1<\/u><br \/>\u622a\u81f32023\u5e7412\u670831\u65e5\uff0c\u516c\u53f8\u6d41\u901a\u5728\u5916\u7684\u666e\u901a\u80a1\u4e3a55,145,839\u80a1\u3002\u6bcf\u4e00\u80a1\u7f8e\u56fd\u5b58\u6258\u80a1\u7968(ADS)\u53ef\u6362\u7b97\u4e3a1.25\u80a1\u666e\u901a\u80a1\u3002<\/p>\n<p><u>\u975e\u7f8e\u56fd\u901a\u7528\u4f1a\u8ba1\u51c6\u5219\uff08<\/u><u>Non-GAAP<\/u><u>\uff09\u4e0b\u7684<\/u><u>\u4e8f\u635f<\/u><br \/>\u975e\u7f8e\u56fd\u901a\u7528\u4f1a\u8ba1\u51c6\u5219\u4e0b\u7684\u51c0\u4e8f\u635f\u5b9a\u4e49\u4e3a\u8be5\u671f\u95f4\u7684\u7f8e\u56fd\u901a\u7528\u4f1a\u8ba1\u51c6\u5219\u4e0b\u7684\u51c0\u4e8f\u635f\u5254\u9664\u80a1\u6743\u6fc0\u52b1\u8d39\u7528\u3002\u8be5\u91d1\u989d\u4ece2022\u5e74\u540c\u671f\u7684\u51c0\u4e8f\u635f6,950\u4e07\u7f8e\u5143\uff0c\u4e0b\u964d\u81f32023\u5e7412\u670831\u65e5\u76841,170\u4e07\u7f8e\u5143\u3002\u8bf7\u53c2\u9605\u672c\u65b0\u95fb\u7a3f\u4e2d\u9898\u4e3a&quot;\u7f8e\u56fd\u901a\u7528\u4f1a\u8ba1\u51c6\u5219\uff08GAAP\uff09\u548c\u975e\u7f8e\u56fd\u901a\u7528\u4f1a\u8ba1\u51c6\u5219\uff08Non-GAAP\uff09\u4e0b\u7684\u4e1a\u7ee9\u8c03\u8282\u8868&quot;\u90e8\u5206\u4e86\u89e3\u8be6\u60c5\u3002<\/p>\n<p>\u5929\u6f14\u836f\u4e1a\u4f7f\u7528Non-GAAP\u51c0\u4e8f\u635f\u548cNon-GAAP\u7684\u6bcf\u80a1\u666e\u901a\u80a1\u51c0\u4e8f\u635f\uff0c\u7528\u4e8e\u8bc4\u4f30\u672c\u516c\u53f8\u7684\u7ecf\u8425\u6210\u679c\uff0c\u4ee5\u53ca\u8d22\u52a1\u548c\u7ecf\u8425\u51b3\u7b56\u3002\u672c\u516c\u53f8\u8ba4\u4e3a\uff0cNon-GAAP\u51c0\u4e8f\u635f\u548cNon-GAAP\u7684\u6bcf\u80a1\u666e\u901a\u80a1\u51c0\u4e8f\u635f\u6709\u52a9\u4e8e\u8bc6\u522b\u672c\u516c\u53f8\u4e1a\u52a1\u7684\u57fa\u672c\u8d8b\u52bf\uff0c\u800c\u8fd9\u4e9b\u8d8b\u52bf\u53ef\u80fd\u56e0\u672c\u516c\u53f8\u8ba1\u5165\u672c\u671f\u95f4\u4e8f\u635f\u7684\u67d0\u4e9b\u8d39\u7528\u7684\u5f71\u54cd\u800c\u626d\u66f2\u3002\u672c\u516c\u53f8\u8ba4\u4e3a\uff0cNon-GAAP\u51c0\u4e8f\u635f\u548cNon-GAAP\u7684\u6bcf\u80a1\u666e\u901a\u80a1\u51c0\u4e8f\u635f\u63d0\u4f9b\u4e86\u6709\u5173\u5176\u7ecf\u8425\u6210\u679c\u7684\u6709\u7528\u4fe1\u606f\uff0c\u6574\u4f53\u63d0\u5347\u4e86\u5bf9\u5176\u8fc7\u53bb\u4e1a\u7ee9\u548c\u672a\u6765\u524d\u666f\u7684\u5168\u9762\u4e86\u89e3\uff0c\u5e76\u4f7f\u7ba1\u7406\u5c42\u5728\u8d22\u52a1\u548c\u8fd0\u8425\u51b3\u7b56\u4e2d\u4f7f\u7528\u7684\u5173\u952e\u6307\u6807\u66f4\u5177\u53ef\u89c1\u6027\u3002<\/p>\n<p>\u5bf9\u4e8e\u672c\u5e74\u5ea6\u7684Non-GAAP\u8d22\u52a1\u6307\u6807\u7684\u8861\u91cf\uff0c\u5929\u6f14\u836f\u4e1a\u4f7f\u7528\u7684Non-GAAP\u51c0\u4e8f\u635f\u548cNon-GAAP\u7684\u6bcf\u80a1\u666e\u901a\u80a1\u51c0\u4e8f\u635f\u4e0d\u5e94\u5355\u72ec\u88ab\u8003\u8651\uff0c\u4e5f\u4e0d\u5e94\u88ab\u89c6\u4e3a\u8be5\u5e74\u5ea6\u8425\u4e1a\u5229\u6da6\u3001\u51c0\u4e8f\u635f\u6216\u4efb\u4f55\u5176\u4ed6\u4e1a\u7ee9\u8861\u91cf\u6307\u6807\u7684\u66ff\u4ee3\u54c1\uff0c\u6216\u4f5c\u4e3a\u5176\u7ecf\u8425\u4e1a\u7ee9\u7684\u8861\u91cf\u6307\u6807\u3002\u516c\u53f8\u9f13\u52b1\u6295\u8d44\u8005\u5ba1\u9605\u8be5\u5e74\u5ea6\u7684Non-GAAP\u51c0\u4e8f\u635f\u548cNon-GAAP\u7684\u6bcf\u80a1\u666e\u901a\u80a1\u51c0\u4e8f\u635f\uff0c\u5e76\u5ba1\u9605\u6700\u76f4\u63a5\u53ef\u6bd4\u7684\u7f8e\u56fd\u901a\u7528\u4f1a\u8ba1\u51c6\u5219\u4e0b\u8d22\u52a1\u6307\u6807\u7684\u8c03\u6574\u8fc7\u7a0b\u3002\u6b64\u5904\u6240\u5217\u671f\u95f4\u7684Non-GAAP\u51c0\u4e8f\u635f\u548cNon-GAAP\u7684\u6bcf\u80a1\u666e\u901a\u80a1\u51c0\u4e8f\u635f\u53ef\u80fd\u65e0\u6cd5\u4e0e\u5176\u4ed6\u516c\u53f8\u63d0\u4f9b\u7684\u7c7b\u4f3c\u540d\u79f0\u7684\u8d22\u52a1\u6307\u6807\u76f8\u6bd4\u8f83\u3002\u5176\u4ed6\u516c\u53f8\u53ef\u80fd\u4f1a\u4ee5\u4e0d\u540c\u7684\u65b9\u5f0f\u8ba1\u7b97\u7c7b\u4f3c\u7684\u8d22\u52a1\u6307\u6807\uff0c\u4ece\u800c\u9650\u5236\u4e86\u5b83\u4eec\u4f5c\u4e3a\u516c\u53f8\u53ef\u6bd4\u6570\u636e\u7684\u6709\u7528\u6027\u3002\u5929\u6f14\u836f\u4e1a\u9f13\u52b1\u6295\u8d44\u8005\u548c\u5176\u4ed6\u4eba\u5168\u9762\u5ba1\u9605\u672c\u516c\u53f8\u7684\u8d22\u52a1\u4fe1\u606f\uff0c\u800c\u4e0d\u662f\u4ec5\u4ec5\u5173\u6ce8\u4e8e\u5355\u4e00\u7684\u8d22\u52a1\u6307\u6807\u3002<\/p>\n<p>\u672c\u5e74\u5ea6\u8ba1\u7b97\u7684\u51c0\u5229\u6da6\u6307\u6807\u4e0bNon-GAAP\u51c0\u4e8f\u635f\u548cNon-GAAP\u7684\u6bcf\u80a1\u666e\u901a\u80a1\u51c0\u4e8f\u635f\uff0c\u4e0d\u5305\u62ec\u80a1\u6743\u6fc0\u52b1\u8d39\u7528\u3002\u80a1\u6743\u6fc0\u52b1\u8d39\u7528\u662f\u5411\u5458\u5de5\u6388\u4e88\u80a1\u7968\u6fc0\u52b1\u6240\u4ea7\u751f\u7684\u975e\u73b0\u91d1\u8d39\u7528\u3002\u6211\u4eec\u8ba4\u4e3a\u7f8e\u56fd\u901a\u7528\u4f1a\u8ba1\u51c6\u5219\u548c\u975e\u7f8e\u56fd\u901a\u7528\u4f1a\u8ba1\u51c6\u5219\u7684\u8c03\u6574\u4fe1\u606f\u80fd\u5bf9\u7ba1\u7406\u5c42\u548c\u6295\u8d44\u4eba\u5728\u8fdb\u884c\u516c\u53f8\u8fd0\u8425\u8868\u73b0\u7684\u540c\u671f\u6bd4\u8f83\u4ee5\u53ca\u540c\u4e1a\u6bd4\u8f83\u65f6\u6709\u6240\u52a9\u76ca\u3002\u5176\u539f\u56e0\u6709\uff1a\uff08i\uff09\u5728\u67d0\u7279\u5b9a\u671f\u95f4\u5185\u7684\u80a1\u6743\u6fc0\u52b1\u8d39\u7528\u4e0e\u516c\u53f8\u7684\u8fd0\u8425\u8868\u73b0\u672a\u5fc5\u76f4\u63a5\u76f8\u5173\uff1b\uff08ii\uff09\u56e0\u516c\u53f8\u6388\u4e88\u65b0\u7684\u80a1\u6743\u6fc0\u52b1\u8ba1\u5212\u7684\u65f6\u95f4\u5b89\u6392\uff0c\u80a1\u6743\u6fc0\u52b1\u8d39\u7528\u5728\u4e0d\u540c\u671f\u95f4\u5185\u53ef\u80fd\u4f1a\u53d1\u751f\u8f83\u5927\u53d8\u5316\uff1b\u4ee5\u53ca\uff0c\uff08iii\uff09\u5176\u4ed6\u516c\u53f8\u53ef\u80fd\u91c7\u53d6\u4e0d\u540c\u7684\u80a1\u6743\u6fc0\u52b1\u5f62\u5f0f\u6216\u8005\u4f7f\u7528\u4e0d\u540c\u7684\u4f30\u503c\u65b9\u6cd5\u3002<\/p>\n<p>\u8bf7\u53c2\u9605\u672c\u516c\u544a\u7ed3\u5c3e\u7684&nbsp;&quot;\u7f8e\u56fd\u901a\u7528\u4f1a\u8ba1\u51c6\u5219\uff08GAAP\uff09\u548c\u975e\u7f8e\u56fd\u901a\u7528\u4f1a\u8ba1\u51c6\u5219\uff08Non-GAAP\uff09\u4e0b\u7684\u4e1a\u7ee9\u8c03\u8282\u8868&quot;\uff0c\u83b7\u53d6\u672c\u5e74\u5ea6\/\u671f\u95f4Non-GAAP\u51c0\u4e8f\u635f\u548cNon-GAAP\u7684\u6bcf\u80a1\u666e\u901a\u80a1\u51c0\u4e8f\u635f\u7684\u5b8c\u6574\u7684\u8c03\u6574\u8fc7\u7a0b\u3002<\/p>\n<p><b>\u5173\u4e8e\u5929\u6f14\u836f\u4e1a<\/b><\/p>\n<p>\u5929\u6f14\u836f\u4e1a\uff08\u7eb3\u65af\u8fbe\u514b\u80a1\u7968\u4ee3\u7801\uff1aADAG\uff09\u662f\u5e73\u53f0\u9a71\u52a8\u5e76\u62e5\u6709\u81ea\u4e3b\u5e73\u53f0\u4ea7\u51fa\u7684\u4e34\u5e8a\u4ea7\u54c1\u5f00\u53d1\u9636\u6bb5\u7684\u751f\u7269\u5236\u836f\u516c\u53f8\uff0c\u516c\u53f8\u81f4\u529b\u4e8e\u53d1\u73b0\u5e76\u5f00\u53d1\u4ee5\u539f\u521b\u6297\u4f53\u4e3a\u57fa\u77f3\u7684\u65b0\u578b\u764c\u75c7\u514d\u75ab\u7597\u6cd5\u3002\u501f\u529b\u4e8e\u8ba1\u7b97\u751f\u7269\u5b66\u4e0e\u4eba\u5de5\u667a\u80fd\uff0c\u51ed\u501f\u5176\u5168\u7403\u9996\u521b\u7684\u4e09\u4f53\u5e73\u53f0\u6280\u672f\uff08\u65b0\u8868\u4f4d\u6297\u4f53NEObody&#x2122;\uff0c\u5b89\u5168\u6297\u4f53SAFEbody<sup>&reg;<\/sup>&nbsp;\u53ca\u5f3a\u529b\u6297\u4f53POWERbody&#x2122;\uff09\uff0c\u5929\u6f14\u836f\u4e1a\u5df2\u5efa\u7acb\u8d77\u805a\u7126\u4e8e\u65b0\u578b\u80bf\u7624\u514d\u75ab\u7597\u6cd5\u7684\u72ec\u7279\u539f\u521b\u7684\u6297\u4f53\u4ea7\u54c1\u7ebf\uff0c\u4ee5\u89e3\u51b3\u5c1a\u672a\u6ee1\u8db3\u7684\u4e34\u5e8a\u9700\u6c42\u3002\u5929\u6f14\u5df2\u548c\u591a\u4e2a\u5168\u7403\u77e5\u540d\u5408\u4f5c\u4f19\u4f34\u8fbe\u6210\u4e86\u6218\u7565\u5408\u4f5c\u5173\u7cfb\uff0c\u5e76\u4ee5\u5176\u591a\u79cd\u539f\u521b\u524d\u6cbf\u79d1\u6280\u4e3a\u5408\u4f5c\u4f19\u4f34\u7684\u65b0\u836f\u7814\u53d1\u8d4b\u80fd\u3002<\/p>\n<p>\u5982\u9700\u4e86\u89e3\u66f4\u591a\u4fe1\u606f\uff0c\u8bf7\u8bbf\u95ee\uff1a&nbsp;<u><a href=\"https:\/\/investor.adagene.com\/\" target=\"_blank\" rel=\"nofollow noopener\">https:\/\/investor.adagene.com&nbsp;<\/a><\/u>\u5e76\u5173\u6ce8\u5929\u6f14\u836f\u4e1a<u><a href=\"https:\/\/t.prnasia.com\/t\/qgUNymgw\" target=\"_blank\" rel=\"nofollow noopener\">\u5fae\u4fe1<\/a><\/u>\u3001<u><a href=\"https:\/\/t.prnasia.com\/t\/QuTV1aBS\" target=\"_blank\" rel=\"nofollow noopener\">\u9886\u82f1<\/a><\/u>\u53ca<u><a href=\"https:\/\/t.prnasia.com\/t\/9qfrA1Nr\" target=\"_blank\" rel=\"nofollow noopener\">\u63a8\u7279<\/a><\/u>\u5b98\u65b9\u5e10\u53f7\u3002<\/p>\n<p>SAFEbody<sup>&reg;<\/sup>&nbsp;\u4e3a\u5929\u6f14\u5728\u7f8e\u56fd\u3001\u4e2d\u56fd\u3001\u6fb3\u5927\u5229\u4e9a\u3001\u65e5\u672c\u3001\u65b0\u52a0\u5761\u548c\u6b27\u76df\u7684\u6ce8\u518c\u5546\u6807\u3002<\/p>\n<p><b>\u5b89\u5168\u6e2f\u58f0\u660e<\/b><\/p>\n<p>\u672c\u65b0\u95fb\u7a3f\u5305\u542b\u524d\u77bb\u6027\u9648\u8ff0\uff0c\u5305\u62ec\u5173\u4e8e\u4e34\u5e8a\u6570\u636e\u5bf9\u60a3\u8005\u7684\u6f5c\u5728\u5f71\u54cd\u7684\u9648\u8ff0\uff0c\u4ee5\u53ca\u5929\u6f14\u836f\u4e1a\u7684\u63a8\u8fdb\u548c\u9884\u671f\u7684\u4e34\u5e8a\u524d\u6d3b\u52a8\u3001\u4e34\u5e8a\u5f00\u53d1\u3001\u76d1\u7ba1\u91cc\u7a0b\u7891\u4ee5\u53ca\u5176\u5019\u9009\u4ea7\u54c1\u7684\u5546\u4e1a\u5316\u3002\u7531\u4e8e\u5404\u79cd\u91cd\u8981\u56e0\u7d20\uff0c\u5305\u62ec\u4f46\u4e0d\u9650\u4e8e\u5929\u6f14\u836f\u4e1a\u8bc1\u660e\u5176\u5019\u9009\u836f\u7269\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u7684\u80fd\u529b\uff0c\u5b9e\u9645\u7ed3\u679c\u53ef\u80fd\u4e0e\u524d\u77bb\u6027\u9648\u8ff0\u4e2d\u6240\u793a\u7684\u7ed3\u679c\u5b58\u5728\u91cd\u5927\u5dee\u5f02\uff1b\u5176\u5019\u9009\u836f\u7269\u7684\u4e34\u5e8a\u7ed3\u679c\uff0c\u53ef\u80fd\u4e0d\u652f\u6301\u8fdb\u4e00\u6b65\u5f00\u53d1\u6216\u76d1\u7ba1\u6279\u51c6\uff1b\u76f8\u5173\u76d1\u7ba1\u673a\u6784\u5c31\u5929\u6f14\u836f\u4e1a\u5019\u9009\u836f\u7269\u7684\u76d1\u7ba1\u6279\u51c6\u505a\u51fa\u51b3\u5b9a\u7684\u5185\u5bb9\u548c\u65f6\u95f4\uff1b\u5982\u679c\u83b7\u5f97\u6279\u51c6\uff0c\u5929\u6f14\u836f\u4e1a\u4e3a\u5176\u5019\u9009\u836f\u7269\u53d6\u5f97\u5546\u4e1a\u6210\u529f\u7684\u80fd\u529b\uff1b\u5929\u6f14\u836f\u4e1a\u4e3a\u5176\u6280\u672f\u548c\u836f\u7269\u83b7\u5f97\u548c\u7ef4\u6301\u77e5\u8bc6\u4ea7\u6743\u4fdd\u62a4\u7684\u80fd\u529b\uff1b\u5929\u6f14\u836f\u4e1a\u4f9d\u8d56\u7b2c\u4e09\u65b9\u8fdb\u884c\u836f\u7269\u5f00\u53d1\u3001\u5236\u9020\u548c\u5176\u4ed6\u670d\u52a1\uff1b\u5929\u6f14\u836f\u4e1a\u6709\u9650\u7684\u7ecf\u8425\u5386\u53f2\u4ee5\u53ca\u5929\u6f14\u836f\u4e1a\u83b7\u5f97\u989d\u5916\u8fd0\u8425\u8d44\u91d1\u4ee5\u53ca\u5b8c\u6210\u5176\u5019\u9009\u836f\u7269\u7684\u5f00\u53d1\u548c\u5546\u4e1a\u5316\u7684\u80fd\u529b\uff1b\u5929\u6f14\u836f\u4e1a\u5728\u5176\u73b0\u6709\u6218\u7565\u4f19\u4f34\u5173\u7cfb\u6216\u5408\u4f5c\u4e4b\u5916\u7b7e\u8ba2\u989d\u5916\u5408\u4f5c\u534f\u8bae\u7684\u80fd\u529b\uff0c\u4ee5\u53caCOVID-19 \u6d41\u884c\u5bf9\u5929\u6f14\u836f\u4e1a\u4e34\u5e8a\u5f00\u53d1\u3001\u5546\u4e1a\u548c\u5176\u4ed6\u8fd0\u8425\u7684\u5f71\u54cd\uff0c\u4ee5\u53ca\u5728\u5929\u6f14\u63d0\u4ea4\u7ed9\u7f8e\u56fd\u8bc1\u5238\u4ea4\u6613\u59d4\u5458\u4f1a\u768420-F\u5f62\u5f0f\u76842022\u5e74\u7684\u5e74\u5ea6\u62a5\u544a\u4e2d&quot;\u98ce\u9669\u56e0\u7d20&quot;\u90e8\u5206\u66f4\u5145\u5206\u8ba8\u8bba\u7684\u90a3\u4e9b\u98ce\u9669\u3002\u6240\u6709\u524d\u77bb\u6027\u9648\u8ff0\u5747\u57fa\u4e8e\u5929\u6f14\u836f\u4e1a\u5f53\u524d\u53ef\u83b7\u5f97\u7684\u4fe1\u606f\uff0c\u9664\u975e\u4f9d\u7167\u6cd5\u5f8b\u4e4b\u53ef\u80fd\u8981\u6c42\uff0c\u5929\u6f14\u836f\u4e1a\u4e0d\u627f\u62c5\u56e0\u65b0\u4fe1\u606f\u3001\u672a\u6765\u4e8b\u4ef6\u6216\u5176\u4ed6\u539f\u56e0\u800c\u516c\u5f00\u66f4\u65b0\u6216\u4fee\u6539\u4efb\u4f55\u524d\u77bb\u6027\u9648\u8ff0\u7684\u4e49\u52a1\u3002<\/p>\n<p>&nbsp;<\/p>\n<div>\n<table border=\"0\" cellspacing=\"0\" cellpadding=\"1\" class=\"prnbcc\">\n<tbody>\n<tr>\n<td class=\"prngen2\" colspan=\"4\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\"><b>\u672a\u7ecf\u5ba1\u8ba1\u7684\u5408\u5e76\u8d44\u4ea7\u8d1f\u503a\u8868\uff08\u7f8e\u56fd\u901a\u7528\u4f1a\u8ba1\u51c6\u5219\uff09<\/b><\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen3\" colspan=\"4\" rowspan=\"1\" nowrap><\/td>\n<\/tr>\n<tr>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap><\/td>\n<td class=\"prngen4\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\"><b>\u622a\u6b62\u81f3<\/b><b>2022<\/b><b>\u5e74<br \/><\/b><b>12<\/b><b>\u6708<\/b><b>31<\/b><b>\u65e5<\/b><\/span><\/p>\n<\/td>\n<td class=\"prngen5\" colspan=\"1\" rowspan=\"1\"><\/td>\n<td class=\"prngen4\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\"><b>\u622a\u6b62\u81f3<\/b><b>2023<\/b><b>\u5e74<br \/><\/b><b>12<\/b><b>\u6708<\/b><b>31<\/b><b>\u65e5<\/b><\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap><\/td>\n<td class=\"prngen6\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\"><b>US$<\/b><\/span><\/p>\n<\/td>\n<td class=\"prngen5\" colspan=\"1\" rowspan=\"1\"><\/td>\n<td class=\"prngen6\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\"><b>US$<\/b><\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\"><b>\u8d44\u4ea7<\/b><\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap><\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\"><\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap><\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\"><b>\u6d41\u52a8\u8d44\u4ea7\uff1a<\/b><\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap><\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\"><\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap><\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml10\"><span class=\"prnews_span\">\u73b0\u91d1\u53ca\u73b0\u91d1\u7b49\u4ef7\u7269<\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">143,758,678<\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\"><\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">109,934,257<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml10\"><span class=\"prnews_span\">\u5e94\u6536\u5173\u8054\u65b9\u6b3e\u9879<\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">619,432<\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\"><\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">222,027<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml10\"><span class=\"prnews_span\">\u5176\u4ed6\u6d41\u52a8\u8d44\u4ea7\u548c\u9884\u4ed8\u8d26\u6b3e<\/span><\/p>\n<\/td>\n<td class=\"prngen7\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">4,937,323<\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\"><\/td>\n<td class=\"prngen7\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">3,287,445<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\"><b>\u6d41\u52a8\u8d44\u4ea7\u603b\u989d<\/b><\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\"><b>149,315,433<\/b><\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\"><\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\"><b>113,443,729<\/b><\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml10\"><span class=\"prnews_span\">\u56fa\u5b9a\u8d44\u4ea7<\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">2,782,963<\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\"><\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">1,835,121<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml10\"><span class=\"prnews_span\">\u4f7f\u7528\u6743\u8d44\u4ea7<\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">191,877<\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\"><\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">365,103<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml10\"><span class=\"prnews_span\">\u5176\u4ed6\u975e\u6d41\u52a8\u8d44\u4ea7<\/span><\/p>\n<\/td>\n<td class=\"prngen7\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">109,572<\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\"><\/td>\n<td class=\"prngen7\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">84,885<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\"><b>\u8d44\u4ea7\u603b\u989d<\/b><\/span><\/p>\n<\/td>\n<td class=\"prngen8\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\"><b>152,399,845<\/b><\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\"><\/td>\n<td class=\"prngen8\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\"><b>115,728,838<\/b><\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">&nbsp;<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\"><b>\u8d1f\u503a\u548c\u80a1\u4e1c\u6743\u76ca<\/b><\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap><\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\"><\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap><\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\"><b>\u6d41\u52a8\u8d1f\u503a\uff1a<\/b><\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap><\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\"><\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap><\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml10\"><span class=\"prnews_span\">\u5e94\u4ed8\u8d26\u6b3e<\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">3,666,124<\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\"><\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">3,093,752<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml10\"><span class=\"prnews_span\">\u5408\u540c\u8d1f\u503a<\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">15,107,276<\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\"><\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">\u2014<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml10\"><span class=\"prnews_span\">\u5e94\u4ed8\u5173\u8054\u65b9\u6b3e\u9879<\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">19,323,337<\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\"><\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">16,714,326<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml10\"><span class=\"prnews_span\">\u9884\u63d0\u53ca\u5176\u4ed6\u6d41\u52a8\u8d1f\u503a<\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">3,212,809<\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\"><\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">3,001,508<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml10\"><span class=\"prnews_span\">\u5e94\u4ed8\u6240\u5f97\u7a0e<\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">\u2014<\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\"><\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">52,884<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml10\"><span class=\"prnews_span\">\u77ed\u671f\u501f\u6b3e<\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">10,768,745<\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\"><\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">4,235,673<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml10\"><span class=\"prnews_span\">\u4e00\u5e74\u5185\u5230\u671f\u7684\u957f\u671f\u501f\u6b3e<\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">2,850,128<\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\"><\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">4,161,549<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml10\"><span class=\"prnews_span\">\u4e00\u5e74\u5185\u5230\u671f\u7684\u79df\u8d41\u8d1f\u503a<\/span><\/p>\n<\/td>\n<td class=\"prngen7\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">151,983<\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\"><\/td>\n<td class=\"prngen7\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">195,955<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\"><b>\u6d41\u52a8\u8d1f\u503a\u603b\u989d<\/b><\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\"><b>55,080,402<\/b><\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\"><\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\"><b>31,455,647<\/b><\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml10\"><span class=\"prnews_span\">\u957f\u671f\u501f\u6b3e<\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">14,146,541<\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\"><\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">13,540,034<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml10\"><span class=\"prnews_span\">\u79df\u8d41\u8d1f\u503a<\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">53,834<\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\"><\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">173,660<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml10\"><span class=\"prnews_span\">\u5176\u4ed6\u975e\u6d41\u52a8\u8d1f\u503a<\/span><\/p>\n<\/td>\n<td class=\"prngen7\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">28,718<\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\"><\/td>\n<td class=\"prngen7\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">\u2014<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\"><b>\u8d1f\u503a\u603b\u989d<\/b><\/span><\/p>\n<\/td>\n<td class=\"prngen7\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\"><b>69,309,495<\/b><\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\"><\/td>\n<td class=\"prngen7\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\"><b>45,169,341<\/b><\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">&nbsp;<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\"><b>\u80a1\u4e1c\u6743\u76ca\uff1a<\/b><\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap><\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\"><\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap><\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml10\"><span class=\"prnews_span\">\u80a1\u672c<\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">5,497<\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\"><\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">5,547<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml10\"><span class=\"prnews_span\">\u5e93\u5b58\u80a1<\/span><\/p>\n<\/td>\n<td class=\"prngen9\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">(4)<\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\"><\/td>\n<td class=\"prngen9\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">(4)<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml10\"><span class=\"prnews_span\">\u8d44\u672c\u516c\u79ef<\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">342,739,268<\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\"><\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">350,105,518<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml10\"><span class=\"prnews_span\">\u5176\u4ed6\u7efc\u5408\u4e8f\u635f<\/span><\/p>\n<\/td>\n<td class=\"prngen9\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">(849,305)<\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\"><\/td>\n<td class=\"prngen9\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">(1,800,088)<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml10\"><span class=\"prnews_span\">\u7d2f\u8ba1\u4e8f\u635f<\/span><\/p>\n<\/td>\n<td class=\"prngen10\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">(258,805,106)<\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\"><\/td>\n<td class=\"prngen10\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">(277,751,476)<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\"><b>\u80a1\u4e1c\u6743\u76ca\u603b\u989d<\/b><\/span><\/p>\n<\/td>\n<td class=\"prngen7\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\"><b>83,090,350<\/b><\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\"><\/td>\n<td class=\"prngen7\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\"><b>70,559,497<\/b><\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\"><b>\u8d1f\u503a\u548c\u80a1\u4e1c\u6743\u76ca\u603b\u989d<\/b><\/span><\/p>\n<\/td>\n<td class=\"prngen8\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\"><b>152,399,845<\/b><\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\"><\/td>\n<td class=\"prngen8\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\"><b>115,728,838<\/b><\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table><\/div>\n<p>&nbsp;<\/p>\n<div>\n<table border=\"0\" cellspacing=\"0\" cellpadding=\"1\" class=\"prnbcc\">\n<tbody>\n<tr>\n<td class=\"prngen2\" colspan=\"4\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\"><b>\u672a\u7ecf\u5ba1\u8ba1\u7684\u5408\u5e76\u5229\u6da6\u8868<\/b><b>\uff08\u7f8e\u56fd\u901a\u7528\u4f1a\u8ba1\u51c6\u5219\uff09<\/b><\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen3\" colspan=\"4\" rowspan=\"1\"><\/td>\n<\/tr>\n<tr>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap><\/td>\n<td class=\"prngen4\" colspan=\"3\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\"><b>\u622a\u81f3<\/b><b>12<\/b><b>\u6708<\/b><b>31<\/b><b>\u65e5\u7684\u5168\u5e74<\/b><\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap><\/td>\n<td class=\"prngen6\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\"><b>2022<\/b><b>\u5e74<\/b><\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\"><\/td>\n<td class=\"prngen6\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\"><b>2023<\/b><b>\u5e74<\/b><\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap><\/td>\n<td class=\"prngen6\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\"><b>US$<\/b><\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\"><\/td>\n<td class=\"prngen6\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\"><b>US$<\/b><\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\"><b>\u6536\u5165<\/b><\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap><\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\"><\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap><\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml10\"><span class=\"prnews_span\">\u6280\u672f\u8bb8\u53ef\u5408\u4f5c\u6536\u5165<\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">9,292,724<\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\"><\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">18,111,491<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\"><b>\u7ecf\u8425<\/b><b>\u8d39\u7528<\/b><b>\u4e0e\u6536\u5165<\/b><\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap><\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\"><\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap><\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml10\"><span class=\"prnews_span\">\u7814\u53d1\u8d39\u7528<\/span><\/p>\n<\/td>\n<td class=\"prngen9\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">(81,339,540)<\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\"><\/td>\n<td class=\"prngen9\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">(36,639,146)<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml10\"><span class=\"prnews_span\">&nbsp; <\/span><span class=\"prnews_span\">\u975e\u5173\u8054\u65b9<\/span><\/p>\n<\/td>\n<td class=\"prngen9\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">(46,212,077)<\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\"><\/td>\n<td class=\"prngen9\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">(33,978,642)<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml10\"><span class=\"prnews_span\">&nbsp; <\/span><span class=\"prnews_span\">\u5173\u8054\u65b9<\/span><\/p>\n<\/td>\n<td class=\"prngen9\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">(35,127,463)<\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\"><\/td>\n<td class=\"prngen9\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">(2,660,504)<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml10\"><span class=\"prnews_span\">\u7ba1\u7406\u8d39\u7528<\/span><\/p>\n<\/td>\n<td class=\"prngen9\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">(11,873,867)<\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\"><\/td>\n<td class=\"prngen9\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">(8,672,843)<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml10\"><span class=\"prnews_span\">\u5176\u4ed6\u51c0\u8425\u4e1a\u6536\u5165<\/span><\/p>\n<\/td>\n<td class=\"prngen7\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">\u2014<\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\"><\/td>\n<td class=\"prngen7\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">3,480,632<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\"><b>\u8425\u4e1a\u4e8f\u635f<\/b><\/span><\/p>\n<\/td>\n<td class=\"prngen9\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\"><b>(83,920,683)<\/b><\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\"><\/td>\n<td class=\"prngen9\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\"><b>(23,719,866)<\/b><\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml10\"><span class=\"prnews_span\">\u5229\u606f\u6536\u5165<\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">377,501<\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\"><\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">4,283,085<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml10\"><span class=\"prnews_span\">\u5229\u606f\u8d39\u7528<\/span><\/p>\n<\/td>\n<td class=\"prngen9\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">(693,323)<\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\"><\/td>\n<td class=\"prngen9\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">(1,107,820)<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml10\"><span class=\"prnews_span\">\u5176\u4ed6\u51c0\u6536\u5165<\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">2,168,388<\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\"><\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">1,843,437<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml10\"><span class=\"prnews_span\">\u6c47\u5151\u635f\u76ca<\/span><\/p>\n<\/td>\n<td class=\"prngen7\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">2,555,325<\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\"><\/td>\n<td class=\"prngen7\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">1,446,202<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\"><b>\u7a0e\u524d\u4e8f\u635f<\/b><\/span><\/p>\n<\/td>\n<td class=\"prngen9\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\"><b>(79,512,792)<\/b><\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\"><\/td>\n<td class=\"prngen9\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\"><b>(17,254,962)<\/b><\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml10\"><span class=\"prnews_span\">\u6240\u5f97\u7a0e\u8d39\u7528<\/span><\/p>\n<\/td>\n<td class=\"prngen10\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">(459,055)<\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\"><\/td>\n<td class=\"prngen10\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">(1,691,408)<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\"><b>\u51c0\u4e8f\u635f<\/b><\/span><\/p>\n<\/td>\n<td class=\"prngen9\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\"><b>(79,971,847)<\/b><\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\"><\/td>\n<td class=\"prngen9\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\"><b>(18,946,370)<\/b><\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\"><b>\u5176\u4ed6\u7efc\u5408\u4e8f\u635f<\/b><\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap><\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\"><\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap><\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml10\"><span class=\"prnews_span\">\u5916\u5e01\u62a5\u8868\u6298\u7b97\u5dee\u5f02<\/span><\/p>\n<\/td>\n<td class=\"prngen10\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">(755,324)<\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\"><\/td>\n<td class=\"prngen10\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">(950,783)<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\"><b>\u7efc\u5408\u4e8f\u635f\u603b\u989d<\/b><\/span><\/p>\n<\/td>\n<td class=\"prngen11\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\"><b>(80,727,171)<\/b><\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\"><\/td>\n<td class=\"prngen11\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\"><b>(19,897,153)<\/b><\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\"><b>\u51c0\u4e8f\u635f<\/b><\/span><\/p>\n<\/td>\n<td class=\"prngen9\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\"><b>(79,971,847)<\/b><\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\"><\/td>\n<td class=\"prngen9\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\"><b>(18,946,370)<\/b><\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\"><b>\u5f52\u5c5e\u4e8e\u666e\u901a\u80a1\u80a1\u4e1c\u51c0\u4e8f\u635f\u603b\u989d<\/b><\/span><\/p>\n<\/td>\n<td class=\"prngen11\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\"><b>(79,971,847)<\/b><\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\"><\/td>\n<td class=\"prngen11\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\"><b>(18,946,370)<\/b><\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\"><b>\u7528\u4e8e\u8ba1\u7b97\u6bcf\u80a1\u666e\u901a\u80a1\u51c0\u635f\u5931\u7684\u52a0\u6743\u5e73\u5747\u666e\u901a\u80a1\u80a1\u6570\uff1a<\/b><\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap><\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\"><\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap><\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml10\"><span class=\"prnews_span\">\u2014<\/span><span class=\"prnews_span\">\u57fa\u672c<\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">54,135,084<\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\"><\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">54,737,530<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml10\"><span class=\"prnews_span\">\u2014<\/span><span class=\"prnews_span\">\u7a00\u91ca\u540e<\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">54,135,084<\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\"><\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">54,737,530<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\"><b>\u6bcf\u80a1\u666e\u901a\u80a1\u51c0\u4e8f\u635f<\/b><\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap><\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\"><\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap><\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml10\"><span class=\"prnews_span\">\u2014<\/span><span class=\"prnews_span\">\u57fa\u672c<\/span><\/p>\n<\/td>\n<td class=\"prngen9\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">(1.48)<\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\"><\/td>\n<td class=\"prngen9\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">(0.35)<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml10\"><span class=\"prnews_span\">\u2014<\/span><span class=\"prnews_span\">\u7a00\u91ca\u540e<\/span><\/p>\n<\/td>\n<td class=\"prngen9\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">(1.48)<\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\"><\/td>\n<td class=\"prngen9\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">(0.35)<\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table><\/div>\n<p>&nbsp;<\/p>\n<div>\n<table border=\"0\" cellspacing=\"0\" cellpadding=\"1\" class=\"prnbcc\">\n<tbody>\n<tr>\n<td class=\"prngen2\" colspan=\"4\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\"><b>\u7f8e\u56fd\u901a\u7528\u4f1a\u8ba1\u51c6\u5219\uff08<\/b><b>GAAP<\/b><b>\uff09\u548c\u975e\u7f8e\u56fd\u901a\u7528\u4f1a\u8ba1\u51c6\u5219\uff08<\/b><b>Non-GAAP<\/b><b>\uff09\u4e0b\u7684\u4e1a\u7ee9\u8c03\u8282\u8868<\/b><\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen3\" colspan=\"4\" rowspan=\"1\"><\/td>\n<\/tr>\n<tr>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap><\/td>\n<td class=\"prngen4\" colspan=\"3\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\"><b>\u622a\u81f3<\/b><b>12<\/b><b>\u6708<\/b><b>31<\/b><b>\u65e5\u7684\u5168\u5e74<\/b><\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap><\/td>\n<td class=\"prngen4\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\"><b>2022<\/b><b>\u5e74<\/b><\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\"><\/td>\n<td class=\"prngen4\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\"><b>2023<\/b><b>\u5e74<\/b><\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\"><\/td>\n<td class=\"prngen6\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\"><b>US$<\/b><\/span><\/p>\n<\/td>\n<td class=\"prnpr4 prnpl2 prnvab prnsbtb1 prnrbrb1 prnsbbb1 prnsblb1\" colspan=\"1\" rowspan=\"1\"><\/td>\n<td class=\"prngen6\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\"><b>US$<\/b><\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">\u7f8e\u56fd\u901a\u7528\u4f1a\u8ba1\u51c6\u5219\u4e0b\u5f52\u5c5e\u4e8e\u666e\u901a\u80a1\u80a1\u4e1c\u51c0\u4e8f\u635f\u603b\u989d<\/span><\/p>\n<\/td>\n<td class=\"prngen9\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\"><b>(79,971,847)<\/b><\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\"><\/td>\n<td class=\"prngen9\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\"><b>(18,946,370)<\/b><\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">\u8c03\u6574\uff1a<\/span><span class=\"prnews_span\">&nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp;&nbsp;<\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap><\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\"><\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap><\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml10\"><span class=\"prnews_span\">\u80a1\u6743\u6fc0\u52b1\u8d39\u7528<\/span><\/p>\n<\/td>\n<td class=\"prngen7\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">10,520,282<\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\"><\/td>\n<td class=\"prngen7\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">7,271,700<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\"><b>\u975e\u7f8e\u56fd\u901a\u7528\u4f1a\u8ba1\u51c6\u5219\u4e0b\u7684\u666e\u901a\u80a1\u80a1\u4e1c\u51c0\u4e8f\u635f\u603b\u989d<\/b><\/span><\/p>\n<\/td>\n<td class=\"prngen11\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\"><b>(69,451,565)<\/b><\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\"><\/td>\n<td class=\"prngen11\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\"><b>(11,674,670)<\/b><\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">\u7528\u4e8e\u8ba1\u7b97\u6bcf\u80a1\u666e\u901a\u80a1\u51c0\u635f\u5931\u7684\u52a0\u6743\u5e73\u5747\u666e\u901a\u80a1\u80a1\u6570\uff1a<\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap><\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\"><\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap><\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml10\"><span class=\"prnews_span\">\u2014<\/span><span class=\"prnews_span\">\u57fa\u672c<\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">54,135,084<\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\"><\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">54,737,530<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml10\"><span class=\"prnews_span\">\u2014<\/span><span class=\"prnews_span\">\u7a00\u91ca\u540e<\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">54,135,084<\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\"><\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">54,737,530<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\"><b>\u975e\u7f8e\u56fd\u901a\u7528\u4f1a\u8ba1\u51c6\u5219\u4e0b\u7684\u6bcf\u80a1\u666e\u901a\u80a1\u51c0\u4e8f\u635f<\/b><\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap><\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\"><\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap><\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml10\"><span class=\"prnews_span\">\u2014<\/span><span class=\"prnews_span\">\u57fa\u672c<\/span><\/p>\n<\/td>\n<td class=\"prngen9\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">(1.28)<\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\"><\/td>\n<td class=\"prngen9\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">(0.21)<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml10\"><span class=\"prnews_span\">\u2014<\/span><span class=\"prnews_span\">\u7a00\u91ca\u540e<\/span><\/p>\n<\/td>\n<td class=\"prngen9\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">(1.28)<\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\"><\/td>\n<td class=\"prngen9\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">(0.21)<\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table><\/div>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>-\u63a9\u853d\u578b\u6297CTLA-4\u5b89\u5168\u6297\u4f53SAFEbody&reg; 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\u5929\u6f14\u836f\u4e1a\uff08\u4ee5\u4e0b\u7b80\u79f0&quot;\u516c\u53f8&quot;\u6216&quot;\u5929\u6f14&quot;\uff09\uff08\u7eb3\u65af\u8fbe\u514b\u80a1\u7968\u4ee3\u7801\uff1aADAG\uff09\u662f\u4e00\u5bb6\u5e73\u53f0\u9a71\u52a8\u7684\u4e34\u5e8a\u9636\u6bb5\u751f\u7269\u5236\u836f\u516c\u53f8\uff0c\u81f4\u529b\u4e8e\u53d1\u73b0\u5e76\u5f00\u53d1\u4ee5\u539f\u521b\u6297\u4f53\u4e3a\u57fa\u77f3\u7684\u65b0\u578b\u7597\u6cd5\u3002\u516c\u53f8\u4eca\u65e5\u516c\u5e03\u4e862023\u5e74\u5168\u5e74\u7684\u8d22\u52a1\u4e1a\u7ee9\u53ca\u6700\u65b0\u4e1a\u52a1\u8fdb\u5c55\u3002 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\u4ed6\u6307\u51fa\uff1a&nbsp;&quot;\u5173\u4e8e\u4e34\u5e8a\u4ea7\u54c1\u7ba1\u7ebf\uff0c\u6211\u4eec\u59cb\u7ec8\u575a\u4fe1\uff0c\u901a\u8fc7\u5b9e\u73b0\u66f4\u9ad8\u5242\u91cf\u66f4\u9ad8\u9891\u7387\u7684\u5b89\u5168\u591a\u6b21\u91cd\u590d\u7ed9\u836f\uff0cCTLA-4\u7597\u6cd5\u53ef\u4ee5\u8054\u5408\u6297PD-1\u53ca\u5176\u4ed6\u7597\u6cd5\u6210\u4e3a\u5e7f\u8c31\u6297\u764c\u7597\u6cd5\u7684\u57fa\u77f3\u3002\u501f\u52a9\u5b89\u5168\u6297\u4f53SAFEbody\u5e73\u53f0\u589e\u5f3a\u80bf\u7624\u5fae\u73af\u5883\u4e0bCTLA-4\u4ecb\u5bfc\u7684\u8c03\u8282\u6027T\u7ec6\u80de\uff08Treg\uff09\u6e05\u9664\u6548\u529b\uff0c\u4e0e\u7eb3\u6b66\u5229\u5c24\u5355\u6297(Nivolumab)+\u4f0a\u5339\u6728\u5355\u6297(Ipilimumab)\u8054\u7528\u76f8\u6bd4\uff0cADG126\u4e0ePD-1\u8054\u7528\u7684\u6cbb\u7597\u6307\u6570\u663e\u8457\u63d0\u5347\u9ad8\u8fbe30\u500d\uff0c\u4ece\u800c\u5145\u5206\u91ca\u653e\u6297CTLA-4\u514d\u75ab\u7597\u6cd5\u7684\u6f5c\u80fd\u3002&quot; &quot;\u503c\u5f97\u4e00\u63d0\u7684\u662f\uff0c\u6211\u4eec\u65b0\u542f\u52a8\u7684\u8d1f\u8377\u5242\u91cf\u7ed9\u836f\u65b9\u6848\u80fd\u8ba9\u63a9\u853d\u578b\u6297CTLA-4\u5728\u80bf\u7624\u5185\u5feb\u901f\u8fbe\u5230\u6fc0\u6d3b\u6297\u4f53\u7684\u7a33\u6001\u6d53\u5ea6\uff0c\u8fc5\u901f\u542f\u52a8CTLA-4\u901a\u8def\u4e0ePD-1\u901a\u8def\u7684\u80bf\u7624\u514d\u75ab\u534f\u540c\u6548\u5e94\uff0c\u6291\u5236\u80bf\u7624\u751f\u957f\u3002\u57fa\u4e8e10 mg\/kg\u7684\u91cd\u590d\u7ed9\u836f\u5242\u91cf\u4e0b\u4ec5\u51fa\u73b0\u6709\u9650\u76843\u7ea7\u6cbb\u7597\u76f8\u5173\u4e0d\u826f\u4e8b\u4ef6\u548c\u6781\u4f4e\u7684\u8fdf\u53d1\u578b\u6bd2\u6027\uff0c\u4ece\u800c\u5b9e\u73b0\u5728\u5feb\u901f\u542f\u52a8\u65e9\u671f\u80bf\u7624\u6291\u5236\u4ee5\u53ca\u957f\u671f\u751f\u5b58\u7684\u4e34\u5e8a\u83b7\u76ca\u3002\u4eca\u5e74\u5c06\u9646\u7eed\u516c\u5e03ADG126\u8054\u7528\u7597\u6cd5\u9488\u5bf9MSS CRC\u7684\u5242\u91cf\u6269\u5c55\u961f\u5217\u66f4\u591a\u4e34\u5e8a\u6210\u679c\u3002&quot; \u4ea7\u54c1\u7ba1\u7ebf\u4eae\u70b9 Ib\/2\u671f\u6570\u636e\u8868\u660e\uff0c\u63a9\u853d\u578b\u5b89\u5168\u6297\u4f53SAFEbody ADG126\u7ed3\u5408\u72ec\u7279\u7684CTLA-4\u8868\u4f4d\uff0c\u57fa\u4e8eCTLA-4\u7684\u751f\u7269\u5b66\u57fa\u7840\uff0c\u9776\u5411\u80bf\u7624\u7ec4\u7ec7\u5185\u8c03\u8282\u6027T\u7ec6\u80de\uff08Tregs\uff09\u4e0e\u9ed8\u6c99\u4e1c\u6297PD-1\u836f\u7269\u5e15\u535a\u5229\u73e0\u5355\u6297\uff08KEYTRUDA&reg;\uff09\u8054\u5408\u7597\u6cd5\u5728\u9488\u5bf9MSS CRC\u3001\u7ecfPD-1\u6cbb\u7597\u5931\u8d25\u540e\u51fa\u73b0\u8fdb\u5c55\u4ee5\u53caPD-L1\u4f4e\u8868\u8fbe\u80bf\u7624\u4e2d\u663e\u793a\u51fa\u540c\u7c7b\u6700\u4f73\u6f5c\u529b\u3002 \u57282024\u5e74\u7f8e\u56fd\u4e34\u5e8a\u80bf\u7624\u5b66\u4f1a\u80c3\u80a0\u9053\u764c\u75c7\uff08ASCO-GI\uff09\u7814\u8ba8\u4f1a\u4e0a\u516c\u5e03\u7684ADG126\u8054\u5408\u5e15\u535a\u5229\u73e0\u5355\u6297\uff08200 mg\uff0c\u6bcf\u4e09\u5468\u4e00\u6b21\uff09\u7684\u5242\u91cf\u9012\u589e\u4e0e\u5242\u91cf\u6269\u5c55\u961f\u5217\u8bd5\u9a8c\u7ed3\u679c\u8868\u660e\uff0cADG126\u57286 mg\/kg\u81f310 mg\/kg\u7684\u5242\u91cf\u8303\u56f4\u5185\u5bf9\u7ecf\u8fc7\u5927\u91cf\u591a\u7ebf\u6cbb\u7597\u7684\u665a\u671f\/\u8f6c\u79fb\u6027\u60a3\u8005\uff08N=46\uff09\u5177\u6709\u5dee\u5f02\u5316\u7684\u5b89\u5168\u6027\uff1a \u89c2\u5bdf\u5230\u6709\u9650\u7684\u5242\u91cf\u4f9d\u8d56\u6027\u6bd2\u6027\u3002 46\u540d\u60a3\u8005\u4e2d\uff0c5\u540d\uff0810.8%\uff09\u51fa\u73b03\u7ea7\u6cbb\u7597\u76f8\u5173\u4e0d\u826f\u4e8b\u4ef6\uff08TRAE\uff09\uff0c\u672a\u51fa\u73b04\u7ea7\u4e0e5\u7ea7\u6cbb\u7597\u76f8\u5173\u4e0d\u826f\u4e8b\u4ef6\uff0c\u4e2d\u65ad\u7387\u4e3a6.5%\uff083\/46\uff09\u3002 \u5728\u9488\u5bf9\u4e0d\u540c\u80bf\u7624\u7c7b\u578b\u7684\u5242\u91cf\u9012\u589e\u8bd5\u9a8c\u4e2d\uff0c\u4ece3\u540d\u63a5\u53d7\u5242\u91cf\u6c34\u5e73\u4e3a10 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