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Medicine\u7684\u53d1\u8868\u4f53\u73b0\u4e86\u5b66\u672f\u6743\u5a01\u5bf9\u4e8eCAPability-01\u7814\u7a76\u7684\u8ba4\u53ef\u3002\u8be5\u7814\u7a76\u8868\u660e\uff0c\u5bf9\u4e8e\u5fae\u536b\u661f\u7a33\u5b9a\/\u9519\u914d\u4fee\u590d\u529f\u80fd\u5b8c\u6574\uff08MSS\/pMMR\uff09\u578b\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c\uff08mCRC\uff09\u60a3\u8005\uff0c\u4e09\u836f\u65b9\u6848\u897f\u8fbe\u672c\u80fa+\u4fe1\u8fea\u5229\u5355\u6297+\u8d1d\u4f10\u73e0\u5355\u6297\u8fdb\u884c\u4e09\u7ebf\u53ca\u4ee5\u4e0a\u6cbb\u7597\uff0c18\u5468PFS\u7387\u8fbe64.0%\uff0cORR\u8fbe44.0%\uff0c\u4e2d\u4f4dPFS\u8fbe7.3\u4e2a\u6708\uff0c\u88ab\u8ba4\u4e3a\u662fMSS\/pMMR\u665a\u671fCRC\u60a3\u8005\u6781\u5177\u524d\u666f\u7684\u6cbb\u7597\u9009\u62e9\u3002<\/li>\n<\/ul>\n<p><b>\uff08<\/b><b>2<\/b><b>\uff09\u897f\u683c\u5217\u4ed6\u94a0<\/b><\/p>\n<p>\u897f\u683c\u5217\u4ed6\u94a0\u662f\u516c\u53f8\u81ea\u4e3b\u7814\u53d1\u7684\u5168\u65b0\u673a\u5236\u80f0\u5c9b\u7d20\u589e\u654f\u5242\uff0c\u7528\u4e8e\u4e8c\u578b\u7cd6\u5c3f\u75c5\u53ca\u4ee3\u8c22\u7efc\u5408\u5f81\uff0c\u5c5e\u4e8e\u5168\u65b0\u5316\u5b66\u5206\u5b50\u4f53\u7684\u56fd\u5bb61\u7c7b\u65b0\u836f\u53ca\u56fd\u5bb6&nbsp;&quot;\u91cd\u5927\u65b0\u836f\u521b\u5236&quot;\u4e13\u9879\u6210\u679c\uff0c\u4e5f\u662f\u5168\u7403\u7b2c\u4e00\u4e2a\u83b7\u6279\u6cbb\u75972\u578b\u7cd6\u5c3f\u75c5\u7684PPAR\u5168\u6fc0\u52a8\u5242\u3002<\/p>\n<p>\u897f\u683c\u5217\u4ed6\u94a0\u6240\u9488\u5bf9\u7684\u662f\u80f0\u5c9b\u7d20\u62b5\u6297\u8fd9\u4e00T2DM\u53d1\u751f\u548c\u53d1\u5c55\u7684\u6838\u5fc3\u673a\u5236\uff0c\u901a\u8fc7\u9002\u5ea6\u6fc0\u6d3bPPAR\u4e09\u4e2a\u53d7\u4f53\uff0c\u4f7f\u5f97\u7cd6\u3001\u8102\u3001\u80fd\u91cf\u548c\u86cb\u767d\u4ee3\u8c22\u8fbe\u5230\u52a8\u6001\u5e73\u8861\u3002\u524d\u671f\u4e34\u5e8a\u7efc\u5408\u7814\u7a76\u7ed3\u679c\u663e\u793a\uff0c\u897f\u683c\u5217\u4ed6\u94a0\u5177\u6709\u826f\u597d\u7684\u5b89\u5168\u6027\u548c\u836f\u4ee3\u3001\u836f\u6548\u52a8\u529b\u5b66\u7279\u5f81\uff0c\u5728T2DM\u60a3\u8005\u7684\u8840\u7cd6\u3001\u8840\u8102\u53ca\u80fd\u91cf\u8c03\u63a7\u4e0a\u663e\u793a\u4e86\u660e\u786e\u7684\u7597\u6548\u3002<\/p>\n<p><u>\u5546\u4e1a\u5316\u53ca\u5176\u4ed6\u9002\u5e94\u75c7\u63a2\u7d22\u60c5\u51b5\uff1a<\/u><\/p>\n<ul type=\"disc\">\n<li>2021\u5e7410\u6708\uff0c\u897f\u683c\u5217\u4ed6\u94a0\u83b7\u6279\u7528\u4e8e2\u578b\u7cd6\u5c3f\u75c5\u30022023\u5e741\u6708\uff0c\u897f\u683c\u5217\u4ed6\u94a0\u88ab\u7eb3\u5165\u56fd\u5bb6\u533b\u4fdd\u76ee\u5f55\u3002<\/li>\n<li>2023\u5e746\u6708\uff0c\u897f\u683c\u5217\u4ed6\u94a0\u8054\u5408\u4e8c\u7532\u53cc\u80cd\u6cbb\u7597\u7ecf\u4e8c\u7532\u53cc\u80cd\u5355\u836f\u63a7\u5236\u4e0d\u4f73\u76842\u578b\u7cd6\u5c3f\u75c5\u7684\u8865\u5145\u9002\u5e94\u75c7\u5df2\u9012\u4ea4\u4e0a\u5e02\u7533\u8bf7\u3002<\/li>\n<li>2023\u5e748\u6708\uff0c\u897f\u683c\u5217\u4ed6\u94a0\u5355\u836f\u6cbb\u7597\u975e\u9152\u7cbe\u6027\u8102\u80aa\u6027\u809d\u708e\uff08NASH\uff09II\u671f\u4e34\u5e8a\u8bd5\u9a8c\u5b8c\u6210\u5165\u7ec4\u3002<\/li>\n<\/ul>\n<p><b>\u7814\u53d1\u6210\u679c\u663e\u8457\uff0c\u4e34\u5e8a\u8bd5\u9a8c\u53d6\u5f97\u91cd\u5927\u8fdb\u5c55<\/b><\/p>\n<p>\u5728\u7814\u53d1\u65b9\u9762\uff0c\u516c\u53f8\u7ee7\u7eed\u52a0\u5927\u6295\u5165\uff0c\u53d6\u5f97\u4e86\u663e\u8457\u7684\u6210\u7ee9\u3002\u5fae\u82af\u751f\u7269\u575a\u6301\u4ee5\u60a3\u8005\u672a\u6ee1\u8db3\u7684\u4e34\u5e8a\u9700\u6c42\u4e3a\u6838\u5fc3\uff0c\u5e94\u7528\u57fa\u4e8eAI\u8f85\u52a9\u8bbe\u8ba1\u548c\u5316\u5b66\u57fa\u56e0\u7ec4\u5b66\u7684\u6574\u5408\u5f0f\u6280\u672f\u5e73\u53f0\uff0c\u4e0d\u65ad\u53d1\u73b0\u5177\u6709\u5dee\u5f02\u5316\u6cbb\u7597\u83b7\u76ca\u7684\u539f\u521b\u65b0\u836f\u3002\u5728\u62a5\u544a\u671f\u5185\uff0c\u516c\u53f8\u4e0d\u4ec5\u6210\u529f\u63d0\u4ea4\u4e86\u4e24\u4e2a\u65b0\u9002\u5e94\u75c7\u7684\u4e0a\u5e02\u7533\u8bf7\uff0c\u8fd8\u5b8c\u6210\u4e86\u591a\u4e2a\u5173\u952e\u548c\u91cd\u8981\u7684\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u5305\u62ec\u897f\u5965\u7f57\u5c3c\u6cbb\u7597\u5c0f\u7ec6\u80de\u80ba\u764c\u7684\u5173\u952e\u2162\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u4ee5\u53ca\u897f\u8fbe\u672c\u80fa\u548c\u897f\u683c\u5217\u4ed6\u94a0\u4e24\u9879\u65b0\u9002\u5e94\u75c7\u7684\u91cd\u8981\u2161\u671f\u4e34\u5e8a\u8bd5\u9a8c\u7684\u5165\u7ec4\u5de5\u4f5c\u3002\u6b64\u5916\uff0c\u516c\u53f8\u8fd8\u6709\u4e24\u4e2a\u65b0\u5206\u5b50\u5b9e\u4f53\u65b0\u836f\u83b7\u6279\u8fdb\u5165\u4e34\u5e8a\u9636\u6bb5\uff0c\u8fdb\u4e00\u6b65\u4e30\u5bcc\u4e86\u516c\u53f8\u7684\u4ea7\u54c1\u7ebf\u3002<\/p>\n<p><b>\uff08<\/b><b>1<\/b><b>\uff09\u65e9\u671f\u7814\u53d1\u9879\u76ee\uff1a<\/b><\/p>\n<p>\u6df1\u5733\u548c\u6210\u90fd\u5c0f\u5206\u5b50\u65e9\u671f\u7814\u53d1\u4e2d\u5fc3\u5b8c\u6210\u4e862\u4e2a\u5019\u9009\u5206\u5b50CS23546\uff08\u5c0f\u5206\u5b50PD-1\u6291\u5236\u5242\uff09\u548cCS32582\uff08Tyk2\u6291\u5236\u5242\uff09\u7684\u4e34\u5e8a\u8bd5\u9a8c\u7533\u8bf7\u5e76\u83b7\u5f97\u6279\u51c6\uff1b&nbsp;CS231295\uff08\u591a\u9776\u70b9\u6fc0\u9176\u6291\u5236\u5242\uff09\u548cCS12088\uff08HBV\u6838\u8863\u58f3\u86cb\u767d\u6291\u5236\u5242\uff09\u5b8c\u6210\u4e86\u5927\u90e8\u5206\u4e34\u5e8a\u524d\u7814\u7a76\u5de5\u4f5c\uff0c\u5176\u4ed6\u9879\u76ee\u6b63\u5728\u5148\u5bfc\u5206\u5b50\u53d1\u73b0\u6216\u5019\u9009\u5206\u5b50\u8bc4\u4f30\u9636\u6bb5\u3002\u76ee\u524d\u8fd8\u5728\u65e9\u671f\u9636\u6bb5\u7684\u9879\u76ee\u5305\u62ec\u80bf\u7624\u9886\u57df\uff089\u9879\uff09\u3001\u6297\u75c5\u6bd2\uff081\u9879\uff09\u3001\u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf\u75be\u75c5\uff081\u9879\uff09\u548c\u4ee3\u8c22\u6027\u75be\u75c5\uff082\u9879\uff09\uff0c\u5176\u4e2d\u591a\u4e2a\u9879\u76ee\u5df2\u7ecf\u83b7\u5f97\u4e86\u6d3b\u6027\u5148\u5bfc\u5206\u5b50\uff0c\u6b63\u5728\u8fdb\u4e00\u6b65\u7684\u4f18\u5316\u8fc7\u7a0b\u4e2d\uff0c\u4e3a\u6269\u5145\u65e9\u671f\u7814\u53d1\u7ba1\u7ebf\u63d0\u4f9b\u6301\u7eed\u652f\u6491\u3002<\/p>\n<p><b>\uff08<\/b><b>2<\/b><b>\uff09\u91cd\u8981\u4e34\u5e8a\u8bd5\u9a8c\u8fdb\u5c55\uff1a<\/b><\/p>\n<p><u>2<\/u><u>\u9879\u4e0a\u5e02\u7533\u8bf7\u9012\u4ea4\uff1a<\/u><\/p>\n<ul type=\"disc\">\n<li>\u897f\u683c\u5217\u4ed6\u94a0\u8054\u5408\u4e8c\u7532\u53cc\u80cd\u6cbb\u75972\u578b\u7cd6\u5c3f\u75c5\u7684\u4e0a\u5e02\u7533\u8bf7\u83b7\u5f97\u53d7\u7406<\/li>\n<li>\u897f\u8fbe\u672c\u80fa\u8054\u5408R-CHOP\u7528\u4e8e\u5f25\u6f2b\u5927B\u7ec6\u80de\u6dcb\u5df4\u7624\u7684\u4e0a\u5e02\u7533\u8bf7\u83b7\u5f97\u53d7\u7406\u5e76\u7eb3\u5165\u4f18\u5148\u5ba1\u8bc4<\/li>\n<\/ul>\n<p><u>2<\/u><u>\u9879\u4e34\u5e8a\u8bd5\u9a8c\u7533\u8bf7\u83b7\u51c6\uff1a<\/u><\/p>\n<ul type=\"disc\">\n<li>CS23546\uff08\u53e3\u670dPD-L1\u6291\u5236\u5242\uff09\u6cbb\u7597\u665a\u671f\u80bf\u7624\u7684I\u671f\u4e34\u5e8a\u8bd5\u9a8c\u83b7\u6279\uff0c\u5b8c\u6210\u9996\u5bb6\u4e2d\u5fc3\u542f\u52a8<\/li>\n<li>CS32582\uff08TYK2\uff09\u80f6\u56ca\u7528\u4e8e\u6cbb\u7597\u94f6\u5c51\u75c5\u7684\u4e34\u5e8a\u8bd5\u9a8c\u7533\u8bf7\u83b7\u5f97\u6279\u51c6<\/li>\n<\/ul>\n<p><u>3<\/u><u>\u9879\u4e34\u5e8a\u8bd5\u9a8c\u5b8c\u6210\u5165\u7ec4<\/u>\uff1a<\/p>\n<ul type=\"disc\">\n<li>\u897f\u683c\u5217\u4ed6\u94a0NASH\u9002\u5e94\u75c7\u7684II\u671f\u4e34\u5e8a\u8bd5\u9a8c\u5b8c\u6210\u5165\u7ec4<\/li>\n<li>\u897f\u5965\u7f57\u5c3c\u5355\u836f\u6cbb\u7597\u5c0f\u7ec6\u80de\u80ba\u764cIII\u671f\u7814\u7a76\u5b8c\u6210\u5165\u7ec4<\/li>\n<li>\u897f\u8fbe\u672c\u80fa+PD-1 \u4e00\u7ebf\u6cbb\u7597\u975e\u5c0f\u7ec6\u80de\u80ba\u764cII\u671f\u4e34\u5e8a\u8bd5\u9a8c\u5b8c\u6210\u5165\u7ec4<\/li>\n<\/ul>\n<p><b>\uff08<\/b><b>3<\/b><b>\uff09\u56fd\u9645\u4e34\u5e8a\u8fdb\u5c55\uff1a<\/b><\/p>\n<ul 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href=\"https:\/\/www.chipscreen.com\/\" target=\"_blank\" rel=\"nofollow noopener\">https:\/\/www.chipscreen.com\/<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u6df1\u57332024\u5e743\u670829\u65e5 \/\u7f8e\u901a\u793e\/ &#8212; 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