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class=\"prntal\">\u622a\u81f32023\u5e7412\u670831\u65e5\u6b62\u5e74\u5ea6\u53ca\u622a\u81f3\u672c\u516c\u544a\u65e5\u671f\uff0c\u6211\u4eec\u7684\u4ea7\u54c1\u7ba1\u7ebf\u53ca\u4e1a\u52a1\u7ecf\u8425\u5747\u5df2\u53d6\u5f97\u91cd\u5927\u8fdb\u5c55\u3002\u6211\u4eec\u5728\u6b64\u671f\u95f4\u53d6\u5f97\u7684\u6210\u5c31\u5305\u62ec\uff1a<\/p>\n<ul type=\"disc\">\n<li>\u603b\u6536\u5165\u8fbe\u4eba\u6c11\u5e014.638\u4ebf\u5143\uff0c\u5305\u62ec\u5546\u4e1a\u6536\u5165\u4eba\u6c11\u5e013.681\u4ebf\u5143\uff0c\u5176\u4e2d\u7cbe\u51c6\u6cbb\u7597\u836f\u7269\u9500\u552e\u989d\u4e3a\u4eba\u6c11\u5e013.367\u4ebf\u5143\uff0c\u8212\u683c\u5229\u5355\u6297\u7279\u8bb8\u6743\u4f7f\u7528\u8d39\u6536\u5165\u4e3a\u4eba\u6c11\u5e013143\u4e07\u5143\u3002\u5176\u4ed6\u6536\u76ca\u53ca\u4e8f\u635f\u4e3a\u4eba\u6c11\u5e011.995\u4ebf\u5143\uff0c\u4e3b\u8981\u662f\u7531\u4e8e\u5c06\u827e\u4f0f\u5c3c\u5e03\u4e1a\u52a1\u7684\u6388\u6743\u8f6c\u8ba9\u7ed9Les Laboratoires Servier\uff08\u65bd\u7ef4\u96c5\uff09\u7684\u6536\u76ca\u51c0\u989d\u4eba\u6c11\u5e011.795\u4ebf\u5143\u3002<\/li>\n<li>\u666e\u62c9\u66ff\u5c3c\u53ca\u8212\u683c\u5229\u5355\u6297\u83b7\u6388\u4e94\u9879\u65b0\u836f\u7533\u8bf7\uff08NDA\uff09\u6279\u51c6\uff1a\u9488\u5bf9\u666e\u62c9\u66ff\u5c3c\uff0c\u5728\u4e2d\u56fd\u5927\u9646\u83b7\u6279\u7528\u4e8e\u4e00\u7ebf\u6cbb\u7597\u8f6c\u67d3\u91cd\u6392\uff08RET\uff09\u878d\u5408\u9633\u6027\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff08NSCLC\uff09\uff0c\u4ece\u800c\u4f7f\u666e\u62c9\u66ff\u5c3c\u5728\u4e00\u7ebf\u53ca\u4e8c\u7ebfNSCLC\u7684\u5e94\u7528\u8303\u56f4\u6269\u5927\uff1b\u5728\u4e2d\u56fd\u53f0\u6e7e\u7528\u4e8e\u6cbb\u7597RET\u878d\u5408\u9633\u6027NSCLC\u3001RET\u7a81\u53d8\u7684\u7532\u72b6\u817a\u9ad3\u6837\u764c\uff08MTC\uff09\u53ca RET\u878d\u5408\u9633\u6027\u7532\u72b6\u817a\u764c\uff08TC\uff09\u3002\u9488\u5bf9\u8212\u683c\u5229\u5355\u6297\uff0c\u5728\u4e2d\u56fd\u5927\u9646\u83b7\u6279\u5355\u836f\u6cbb\u7597\u590d\u53d1\u6216\u96be\u6cbb\u6027\uff08R\/R\uff09\u7ed3\u5916\u81ea\u7136\u6740\u4f24\u7ec6\u80de\/T\u7ec6\u80de\u6dcb\u5df4\u7624\uff08ENKTL\uff09\uff1b\u5728\u4e2d\u56fd\u5927\u9646\u83b7\u6279\u8054\u5408\u5316\u7597\u7528\u4e8e\u6cbb\u7597\u4e00\u7ebf\u98df\u7ba1\u9cde\u764c\uff08ESCC\uff09\u53ca\u5728\u4e2d\u56fd\u5927\u9646\u83b7\u6279\u8054\u5408\u5316\u7597\u7528\u4e8e\u4e00 \u7ebf\u6cbb\u7597\u80c3\u817a\u764c\/\u80c3\u98df\u7ba1\u7ed3\u5408\u90e8\u817a\u764c\uff08GC\/GEJ\uff09\u3002<\/li>\n<li>\u4e24\u9879NDA\u73b0\u5904\u4e8e\u5ba1\u8bc4\u4e2d\uff1a\u5728\u82f1\u56fd\u8212\u683c\u5229\u5355\u6297\u8054\u5408\u5316\u7597\u7528\u4e8e\u6cbb\u7597\u4e00\u7ebfIV\u671fNSCLC\u53ca\u5728\u6b27\u76df\u8212\u683c\u5229\u5355\u6297\u8054\u5408\u5316\u7597\u7528\u4e8e\u6cbb\u7597\u4e00\u7ebfIV\u671f NSCLC\u3002\u6b27\u6d32\u836f\u54c1\u7ba1\u7406\u5c40\uff08EMA\uff09\u5df2\u5728\u4e24\u4e2a\u7814\u7a76\u4e2d\u5fc3\u53ca\u533b\u836f\u7814\u53d1\u5408\u540c\u5916\u5305\u670d\u52a1\u673a\u6784\uff08CRO\uff09\u5b8c\u6210\u9488\u5bf9\u4e00\u7ebfIV\u671fNSCLC\u7684\u836f\u7269\u4e34\u5e8a\u8bd5\u9a8c\u8d28\u91cf\u7ba1\u7406\u89c4\u8303\uff08GCP\uff09\u68c0\u67e5\u3002<\/li>\n<li>CS5001\u56fd\u9645\u591a\u4e2d\u5fc3\u4e34\u5e8a\u8bd5\u9a8c\u8fdb\u5c55\u8fc5\u901f\uff1aCS5001\uff08\u4e00\u79cd\u53d7\u4f53\u916a\u6c28\u9178\u6fc0\u9176\u6837\u5b64\u513f\u53d7\u4f531\uff08ROR1\uff09\u6297\u4f53\u5076\u8054\u836f\u7269\uff08ADC\uff09\uff09\u9996\u6b21\u4eba\u4f53\uff08FIH\uff09\u5168\u7403\u8bd5\u9a8c\u5728\u7f8e\u56fd\u3001\u6fb3\u5927\u5229\u4e9a\u53ca\u4e2d\u56fd\u8fdb\u884c\u4e2d\uff1bCS5001\u5177\u6709\u826f\u597d\u7684\u8010\u53d7\u6027\u548c\u5b89\u5168\u6027\uff0c\u5e76\u5728\u5b9e\u4f53\u7624\u548c\u6dcb\u5df4\u7624\u4e2d\u663e\u793a\u51fa\u826f\u597d\u7684\u6297\u80bf\u7624\u6d3b\u6027\u3002\u8fc4\u4eca\u4e3a\u6b62\uff0cCS5001 \u662f\u9996\u4e2a\u5728\u5b9e\u4f53\u7624\u4e2d\u663e\u793a\u51fa\u4e34\u5e8a\u6297\u80bf\u7624\u6d3b\u6027\u7684ROR1 ADC\u3002<\/li>\n<li>\u5176\u4ed6\u91cd\u8981\u4e34\u5e8a\u9879\u76ee\u8fdb\u5c55\u987a\u5229\uff1a\u6d1b\u62c9\u66ff\u5c3c\u9488\u5bf9c-ros oncogene1\uff08ROS1\uff09\u9633\u6027\u665a\u671fNSCLC\u5728\u4e2d\u56fd\u5927\u9646\u7684\u5173\u952e\u7814\u7a76\u8fbe\u5230\u4e3b\u8981\u7814\u7a76\u7ec8\u70b9\uff1bnofazinlimab\u8054\u5408 LENVIMA<sup>&reg;<\/sup> (lenvatinib)\u7528\u4e8e\u6cbb\u7597\u4e00\u7ebf\u4e0d\u53ef\u5207\u9664\u6216\u8f6c\u79fb\u6027\u809d\u7ec6\u80de\u764c\uff08HCC\uff09\u7684\u5168\u7403III\u671f\u8bd5\u9a8c\u6b63\u5728\u8fdb\u884c\u6301\u7eed\u968f\u8bbf\u3002<\/li>\n<li>\u4e8e\u5168\u7403\u5b66\u672f\u4f1a\u8bae\uff08\u5982\u7f8e\u56fd\u4e34\u5e8a\u80bf\u7624\u5b66\u4f1a\uff08ASCO\uff09\u5e74\u4f1a\u3001\u6b27\u6d32\u80bf\u7624\u5185\u79d1\u5b66\u4f1a\uff08ESMO\uff09\u5927\u4f1a\u3001ESMO\u4e16\u754c\u80c3\u80a0\u9053\u80bf\u7624\u5927\u4f1a\uff08ESMO GI\u5927\u4f1a\uff09\uff09\u5c55\u793a\u6216\u4e8e\u9876\u5c16\u533b\u5b66\u671f\u520a\uff08\u5982\u300a\u4e34\u5e8a\u80bf\u7624\u5b66\u6742\u5fd7\u300b\u3001\u300aNature Medicine\u300b\u53ca\u300aNature Cancer\u300b\uff09\u53d1\u5e03\u5341\u9879\u76f8\u5173\u6570\u636e\u3002<\/li>\n<li>\u5f00\u5c55\u8d85\u8fc7\u5341\u4e2a\u53d1\u73b0\u9636\u6bb5\u9879\u76ee\uff0c\u5305\u62ec\u591a\u7279\u5f02\u6027\u6297\u4f53\u3001\u6297\u4f53\u5076\u8054\u836f\u7269\u53ca\u7528\u4e8e\u6cbb\u7597\u96be\u6cbb\u6027\u7ec6\u80de\u5185\u9776\u70b9\u7684\u4e13\u6709\u7ec6\u80de\u7a7f\u900f\u6cbb\u7597\uff08CPT\uff09\u5e73\u53f0\uff1b\u4e00\u4e2a\u591a\u7279\u5f02\u6027\u6297\u4f53\u9879\u76ee\u53ca\u4e00\u4e2aADC\u9879\u76ee\u5df2\u8fdb\u5165\u4e34\u5e8a\u524d\u5019\u9009\u836f\u7269\uff08PCC\uff09\u9636\u6bb5\u3002<\/li>\n<li>\u5df2\u5efa\u7acb\u4e09\u9879\u5546\u4e1a\u5408\u4f5c\uff0c\u4ece\u800c\u501f\u52a9\u591a\u5bb6\u516c\u53f8\u7684\u4f18\u52bf\uff0c\u540c\u65f6\u4f7f\u57fa\u77f3\u836f\u4e1a\u80fd\u591f\u6218\u7565\u6027\u5730\u4e13\u6ce8\u4e8e\u672a\u6765\u7814\u53d1\uff1a\u5728\u4e2d\u56fd\u5c31nofazinlimab\u4e0e\u4e09\u751f\u5236\u836f\u5efa\u7acb\u65b0\u7684\u5408\u4f5c\u4f19\u4f34\u5173\u7cfb\uff0c\u4ee5\u52a0\u5febnofazinlimab\u5316\u5b66\u6210\u5206\u751f\u4ea7\u548c\u63a7\u5236\uff08CMC\uff09\u7684\u5f00\u53d1\u53ca\u5546\u4e1a\u5316\uff1b\u5728\u4e2d\u56fd\u5c31\u666e\u5409\u534e<sup>&reg;<\/sup>\uff08\u666e\u62c9\u66ff\u5c3c\uff09\u4e0e\u827e\u529b\u65af\u533b\u836f\uff08\u827e\u529b\u65af\uff09\u5efa\u7acb\u65b0\u7684\u5408\u4f5c\u4f19\u4f34\u5173\u7cfb\uff0c\u4ee5\u663e\u8457\u6269\u5927\u5546\u4e1a\u5316\u652f\u6301\u53ca\u63d0\u9ad8\u8be5\u4e1a\u52a1\u7684\u6574\u4f53\u76c8\u5229\u80fd\u529b\uff1b\u6211\u4eec\u6309\u6700\u591a5\u5343\u4e07\u7f8e\u5143\uff08\u5305\u62ec\u9996\u4ed8\u6b3e4 \u53434\u767e\u4e07\u7f8e\u5143\uff09\u7684\u8f6c\u8ba9\u4ef7\uff0c\u5c06\u62d3\u8212\u6c83<sup>&reg;<\/sup>\uff08\u827e\u4f0f\u5c3c\u5e03\uff09\u5728\u5927\u4e2d\u534e\u533a\u53ca\u65b0\u52a0\u5761\u7684\u6743\u5229\u8f6c\u8ba9\u4e88\u5168\u7403\u8bb8\u53ef\u8bc1\u6301\u6709\u4ebaLes Laboratois Servier\uff08\u65bd\u7ef4\u96c5\uff09\uff0c\u4ee5\u6536\u56de\u5bf9\u8be5\u8d44\u4ea7\u7684\u8fc7\u5f80\u6295\u8d44\u53ca\u53d8\u73b0\u672a\u6765\u6f5c\u5728\u73b0\u91d1\u6d41\u3002<\/li>\n<li>\u963f\u4f10\u66ff\u5c3c\u7684\u6280\u672f\u8f6c\u79fb\u7533\u8bf7\u6b63\u5904\u5728\u4e2d\u56fd\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08\u56fd\u5bb6\u836f\u76d1\u5c40\uff09\u836f\u54c1\u5ba1\u8bc4\u4e2d\u5fc3\uff08CDE\uff09\u7684\u5ba1\u6838\u4e2d\u3002\u666e\u62c9\u66ff\u5c3c\u6280\u672f\u8f6c\u79fb\uff08\u5305\u62ec\u751f\u4ea7\u53ca\u4e34\u5e8a\u751f\u7269\u7b49\u6548\u6027\uff08\u751f\u7269\u7b49\u6548\u6027\uff09\u7814\u7a76\uff09\u5df2\u5b8c\u6210\uff0c\u7533\u8bf7\u8d44\u6599\u5df2\u63d0\u4ea4\u4e88CDE\u3002\u8fd9\u5c06\u6709\u52a9\u4e8e\u964d\u4f4e\u6210\u672c\u5e76\u63d0\u9ad8\u4ea7\u54c1\u7684\u957f\u671f\u76c8\u5229\u80fd\u529b\u3002<\/li>\n<\/ul>\n<p class=\"prntal\">&nbsp;<\/p>\n<p class=\"prntal\"><b>I. \u901a\u8fc7\u5408\u4f5c\u5173\u7cfb\u5b9e\u73b0\u5546\u4e1a\u4ef7\u503c\u6700\u5927\u5316<\/b><\/p>\n<p class=\"prntal\">\u622a\u81f3\u672c\u516c\u544a\u65e5\u671f\uff0c\u6211\u4eec\u7684\u5546\u4e1a\u6d3b\u52a8\u6458\u8981\u53ca\u8be6\u60c5\u5982\u4e0b\uff1a<\/p>\n<ul type=\"disc\">\n<li><b>\u4e0e\u591a\u5bb6\u516c\u53f8\u5728\u4e2d\u56fd\u5927\u9646\u8fdb\u884c\u5546\u4e1a\u5408\u4f5c<\/b><\/li>\n<\/ul>\n<p class=\"prngen2\">\u4e3a\u8fdb\u4e00\u6b65\u63d0\u9ad8\u5546\u4e1a\u5316\u6548\u7387\uff0c\u5e74\u5185\u6211\u4eec\u5df2\u4e0e\u591a\u5bb6\u516c\u53f8\u5efa\u7acb\u5546\u4e1a\u5408\u4f5c\uff0c\u5728\u5145\u5206\u53d1\u6325\u5404\u81ea\u4f18\u52bf\u7684\u540c\u65f6\uff0c\u57fa\u77f3\u836f\u4e1a\u4e5f\u5c06\u81ea\u8eab\u66f4\u591a\u6218\u7565\u91cd\u5fc3\u805a\u7126\u4e8e\u7814\u53d1\u3002<\/p>\n<p class=\"prnml40\">&#8211; 2023\u5e7411\u6708\uff0c\u6211\u4eec\u5411\u827e\u529b\u65af\u6388\u51faRET\u6291\u5236\u5242\u666e\u5409\u534e<sup>&reg;<\/sup>\uff08\u666e\u62c9\u66ff\u5c3c\uff09\u5728\u4e2d\u56fd\u5927\u9646\u7684\u72ec\u5bb6\u5546\u4e1a\u5316\u6743\u5229\u3002\u6b64\u9879\u4ea4\u6613\u5c06\u666e\u5409\u534e<sup>&reg;<\/sup>\uff08\u666e\u62c9\u66ff\u5c3c\uff09\u7eb3\u5165\u827e\u529b\u65af\u7684\u9ad8\u5ea6\u534f\u540c\u80ba\u764c\u4e1a\u52a1\u90e8\uff0c\u5e76\u4f7f\u666e\u5409\u534e<sup>&reg;<\/sup>\uff08\u666e\u62c9\u66ff\u5c3c\uff09\u80fd\u591f\u53d7\u76ca\u4e8e\u827e\u529b\u65af\u66f4\u6210\u719f\u7684\u5546\u4e1a\u56e2\u961f\u53ca\u66f4\u5e7f\u6cdb\u7684\u5e02\u573a\u8986\u76d6\u8303\u56f4\uff0c\u540c\u65f6\u4f7f\u57fa\u77f3\u836f\u4e1a\u80fd\u591f\u964d\u4f4e\u4e0e\u666e\u5409\u534e<sup>&reg;<\/sup>\uff08\u666e\u62c9\u66ff\u5c3c\uff09\u5546\u4e1a\u5316\u76f8\u5173\u7684\u8fd0\u8425\u6210\u672c\uff0c\u4ece\u800c\u63d0\u5347\u6574\u4f53\u76c8\u5229\u80fd\u529b\u3002<\/p>\n<p class=\"prnml40\">&#8211; 2023\u5e7412\u6708\uff0c\u6211\u4eec\u5c06\u5728\u5927\u4e2d\u534e\u533a\uff08\u5305\u62ec\u4e2d\u56fd\u5927\u9646\u3001\u9999\u6e2f\u3001\u6fb3\u95e8\u53ca\u53f0\u6e7e\uff09\u53ca\u65b0\u52a0\u5761\u5f00\u53d1\u3001\u751f\u4ea7\u53ca\u5546\u4e1a\u5316\u62d3\u8212\u6c83<sup>&reg;<\/sup>\uff08\u827e\u4f0f\u5c3c\u5e03\uff09\u7684\u72ec\u5bb6\u6743\u5229\u8f6c\u8ba9\u4e88\u65bd\u7ef4\u96c5\uff0c\u5e76\u5c06\u6700\u591a\u83b7\u5f975\u5343\u4e07\u7f8e\u5143\u7684\u8f6c\u8ba9\u4ef7\u6b3e\u3002\u8be5\u4ea4\u6613\u5c06\u6709\u52a9\u4e8e\u6269\u5927\u62d3\u8212\u6c83<sup>&reg;<\/sup>\uff08\u827e\u4f0f\u5c3c\u5e03\uff09\u7684\u9002\u5e94\u75c7\u5e76\u63d0\u9ad8\u5176\u5bf9\u5927\u4e2d\u534e\u533a\u53ca\u65b0\u52a0\u5761\u60a3\u8005\u7684\u53ef\u53ca\u6027\uff0c\u540c\u65f6\u53d8\u73b0\u57fa\u77f3\u836f\u4e1a\u7684\u672a\u6765\u6f5c\u5728\u73b0\u91d1\u6d41\u53ca\u6536\u56de\u5bf9\u8be5\u8d44\u4ea7\u7684\u8fc7\u5f80\u6295\u8d44\u3002<\/p>\n<ul type=\"disc\">\n<li><b>\u65b0\u9002\u5e94\u75c7\u5b9e\u73b0\u6210\u529f\u4e0a\u5e02<\/b><\/li>\n<\/ul>\n<p class=\"prngen2\">\u6211\u4eec\u6269\u5927\u4e0a\u5e02\u4ea7\u54c1\u7684\u9002\u5e94\u75c7\uff0c\u65e8\u5728\u4e3a\u672a\u6765\u8d21\u732e\u7a33\u5b9a\u7684\u6536\u76ca\u3002<\/p>\n<p class=\"prnml40\">&#8211; \u666e\u5409\u534e<sup>&reg;<\/sup>\uff08\u666e\u62c9\u66ff\u5c3c\uff09\uff1a\u4e00\u7ebf\u6cbb\u7597\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027RET\u878d\u5408\u9633\u6027NSCLC\u60a3\u8005\u7684\u65b0\u9002\u5e94\u75c7\u5728\u4e2d\u56fd\u5927\u9646\u4e0a\u5e02\u3002<\/p>\n<p class=\"prnml40\">&#8211; \u666e\u5409\u534e<sup>&reg;<\/sup>\uff08\u666e\u62c9\u66ff\u5c3c\uff09\uff1a\u6cbb\u7597\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027RET\u878d\u5408\u9633\u6027NSCLC\u3001\u665a\u671f\u6216\u8f6c\u79fb\u6027RET\u7a81\u53d8MTC\u53caRET\u878d\u5408\u9633\u6027TC\u60a3\u8005\u7684\u9002\u5e94\u75c7\u5728\u4e2d\u56fd\u53f0\u6e7e\u4e0a\u5e02\u3002<\/p>\n<p class=\"prnml40\">&#8211; \u62e9\u6377\u7f8e<sup>&reg;<\/sup>\uff08\u8212\u683c\u5229\u5355\u6297\uff09\uff1a\u8054\u5408\u6c1f\u5c3f\u5627\u5576\u53ca\u542b\u94c2\u5316\u7597\u7528\u4e8e\u4e00\u7ebf\u6cbb\u7597\u4e0d\u53ef\u5207\u9664\u5c40\u90e8\u665a\u671f\u3001\u590d\u53d1\u6216\u8f6c\u79fb\u6027ESCC\u60a3\u8005\u7684\u65b0\u9002\u5e94\u75c7\u5728\u4e2d\u56fd\u5927\u9646\u4e0a\u5e02\u3002<\/p>\n<p class=\"prnml40\">&#8211; \u62e9\u6377\u7f8e<sup>&reg;<\/sup>\uff08\u8212\u683c\u5229\u5355\u6297\uff09\uff1a\u5355\u836f\u6cbb\u7597R\/R ENKTL\u60a3\u8005\u7684\u65b0\u9002\u5e94\u75c7\u5728\u4e2d\u56fd\u5927\u9646\u4e0a\u5e02\u3002<\/p>\n<p class=\"prnml40\">&#8211; \u62e9\u6377\u7f8e<sup>&reg;<\/sup>\uff08\u8212\u683c\u5229\u5355\u6297\uff09\uff1a\u8054\u5408\u5316\u7597\u7528\u4e8e\u4e00\u7ebf\u6cbb\u7597\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027GC\/GEJC\u60a3\u8005\u7684\u65b0\u9002\u5e94\u75c7\u5728\u4e2d\u56fd\u5927\u9646\u4e0a\u5e02\u3002<\/p>\n<ul type=\"disc\">\n<li><b>\u5236\u5b9a\u4e00\u7cfb\u5217\u65b9\u6cd5\uff0c\u63d0\u9ad8\u6211\u4eec\u836f\u54c1\u7684\u53ef\u53ca\u6027\u53ca\u53ef\u8d1f\u62c5\u6027<\/b><\/li>\n<\/ul>\n<p class=\"prnml40\">&#8211; \u6211\u4eec\u5df2\u66f4\u65b0\u4e0a\u5e02\u4ea7\u54c1\u7684\u5b9a\u4ef7\u7b56\u7565\u3002\u5177\u4f53\u800c\u8a00\uff0c\u6cf0\u5409\u534e<sup>&reg;<\/sup>\uff08\u963f\u4f10\u66ff\u5c3c\uff09\u5df2\u88ab\u7eb3\u5165\u4e2d\u56fd\u56fd\u5bb6\u57fa\u672c\u533b\u7597\u4fdd\u9669\u3001\u5de5\u4f24\u4fdd\u9669\u548c\u751f\u80b2\u4fdd\u9669\u836f\u54c1\u76ee\u5f55\uff082023\u5e74\uff09\uff08\u56fd\u5bb6\u533b\u4fdd\u76ee\u5f55\uff09\uff0c\u7528\u4e8e\u6cbb\u7597\u643a\u5e26PDGFRA\u5916\u663e\u5b5018\u7a81\u53d8\uff08\u5305\u62ecPDGFRA D842V\u7a81\u53d8\uff09\u7684\u4e0d\u53ef\u5207\u9664\u6216\u8f6c\u79fb\u6027\u80c3\u80a0\u9053\u95f4\u8d28\u7624\uff08GIST\uff09\u6210\u4eba\u60a3\u8005\u3002<\/p>\n<p class=\"prnml40\">&#8211; \u66f4\u65b0\u666e\u5409\u534e<sup>&reg;<\/sup>\uff08\u666e\u62c9\u66ff\u5c3c\uff09\u53ca\u62d3\u8212\u6c83<sup>&reg;<\/sup>\uff08\u827e\u4f0f\u5c3c\u5e03\uff09\u60a3\u8005\u63f4\u52a9\u9879\u76ee\uff08PAP\uff09\u8ba1\u5212\u4ee5\u4e3a\u4e00\u4e9b\u652f\u4ed8\u80fd\u529b\u4f4e\u7684\u60a3\u8005\u964d\u4f4e\u95e8\u69db\u5e76\u63d0\u5347\u4ef7\u683c\u7ade\u4e89\u529b\u3002<\/p>\n<ul type=\"disc\">\n<li><b>\u5efa\u7acb\u5e7f\u6cdb\u7684\u884c\u4e1a\u548c\u5b66\u672f\u8ba4\u77e5\u5ea6\uff0c\u6811\u7acb\u54c1\u724c\u548c\u79d1\u5b66\u9886\u5bfc\u529b<\/b><\/li>\n<\/ul>\n<p class=\"prnml40\">&#8211; \u666e\u5409\u534e<sup>&reg;<\/sup>\uff08\u666e\u62c9\u66ff\u5c3c\uff09\u3001\u6cf0\u5409\u534e<sup>&reg;<\/sup>\uff08\u963f\u4f10\u66ff\u5c3c\uff09\u53ca\u62d3\u8212\u6c83<sup>&reg;<\/sup>\uff08\u827e\u4f0f\u5c3c\u5e03\uff09\u5df2\u7eb3\u516521\u9879\u4e2d\u56fd\u56fd\u5bb6\u6307\u5357\uff0c\u7528\u4e8e\u591a\u4e2a\u6cbb\u7597\u9886\u57df\u7684\u68c0\u6d4b\u53ca\u6cbb\u7597\uff0c\u6bd4\u5982NSCLC\u3001TC\u3001GIST\u3001\u7cfb\u7edf\u6027\u80a5\u5927\u7ec6\u80de\u589e\u751f\u75c7\uff08SM\uff09\u53ca\u6025\u6027\u9ad3\u7cfb\u767d\u8840\u75c5\uff08AML\uff09\u7b49\u3002\u7279\u522b\u662f\uff0c\u4e2d\u56fd\u4e34\u5e8a\u80bf\u7624\u5b66\u4f1a\uff08CSCO\uff09\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u8bca\u7597\u6307\u5357\uff082023\u5e74\u7248\uff09\u3001CSCO\u80c3\u80a0\u9053\u95f4\u8d28\u7624\u8bca\u7597\u6307\u5357\uff082022\u5e74\u7248\uff09\u3001\u4e2d\u56fd\u6210\u4eba\u7cfb\u7edf\u6027\u80a5\u5927\u7ec6\u80de\u589e\u591a\u75c7\u8bca\u7597\u6307\u5357\uff082022\u5e74\u7248\uff09\u53ca\u4e2d\u56fd\u6297\u764c\u534f\u4f1a\uff08CACA\uff09\u8840\u6db2\u80bf\u7624\u6307\u5357\uff082022\u5e74\u7248\uff09\u7b49\u3002<\/p>\n<p class=\"prnml40\">&#8211; \u6211\u4eec\u7ee7\u7eed\u4e0e\u7814\u7a76\u8005\u5408\u4f5c\u8fdb\u884c\u4e0a\u5e02\u540e\u4e34\u5e8a\u9879\u76ee\uff0c\u5982\u7814\u7a76\u8005\u53d1\u8d77\u7684\u8bd5\u9a8c\uff08IIT\uff09\u548c\u771f\u5b9e\u4e16\u754c\u7684\u7814\u7a76\uff08RWS\uff09\uff0c\u4ee5\u4e8e\u591a\u4e2a\u764c\u75c7\u9002\u5e94\u75c7\u4e2d\u751f\u6210\u66f4\u591a\u6570\u636e\u3002\u4f8b\u5982\uff0c\u4e00\u9879\u591a\u4e2d\u5fc3RWS\u8bc4\u4f30\u4e86\u6cf0\u5409\u534e<sup>&reg;<\/sup>\uff08\u963f\u4f10\u66ff\u5c3c\uff09\u5728\u4e2d\u56fdGIST\u60a3\u8005\u4e2d\u7684\u5b89\u5168\u6027\u53ca\u7597\u6548\uff1b\u53e6\u4e00\u9879IIT\u65e8\u5728\u7814\u7a76\u6cf0\u5409\u534e<sup>&reg;<\/sup>\uff08\u963f\u4f10\u66ff\u5c3c\uff09\u5bf9\u4e8e\u6cbb\u7597\u643a\u5e26\u6709KIT D816\u6216N822\u7a81\u53d8\u7684R\/R \u6838\u5fc3\u7ed3\u5408\u56e0\u5b50\uff08CBF\uff09-AML\u60a3\u8005\u7684\u7597\u6548\u53ca\u5b89\u5168\u6027\u3002<\/p>\n<ul type=\"disc\">\n<li><b>\u4e0e\u8f89\u745e\u5c31\u8212\u683c\u5229\u5355\u6297\u5728\u4e2d\u56fd\u7684\u5546\u4e1a\u5316\u8fdb\u884c\u5408\u4f5c<\/b><\/li>\n<\/ul>\n<p class=\"prnml40\">&#8211; \u6211\u4eec\u6b63\u4e0e\u5408\u4f5c\u4f19\u4f34\u8f89\u745e\u5c55\u5f00\u5bc6\u5207\u5408\u4f5c\uff0c\u4ee5\u63a8\u8fdb\u62e9\u6377\u7f8e<sup>&reg;<\/sup>\uff08\u8212\u683c\u5229\u5355\u6297\uff09\u5728\u4e2d\u56fd\u5927\u9646\u7684\u5546\u4e1a\u5316\u3002<\/p>\n<p class=\"prnml40\">&#8211; 2023\u5e74\uff0c\u62e9\u6377\u7f8e<sup>&reg;<\/sup>\uff08\u8212\u683c\u5229\u5355\u6297\uff09\u4f5c\u4e3aIII\u671fNSCLC\u7684\u6cbb\u7597\u65b9\u6848\u5728CSCO\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u6cbb\u7597\u6307\u5357\uff082023\u5e74\u7248\uff09\u53caCSCO\u514d\u75ab\u6cbb\u7597\u6307\u5357\uff082023\u5e74\u7248\uff09\u4e2d\u5df2\u5347\u7ea7\u81f3\u4e00\u7ea7\u63a8\u8350\u3002\u6b64\u5916\uff0c\u62e9\u6377\u7f8e<sup>&reg;<\/sup>\uff08\u8212\u683c\u5229\u5355\u6297\uff09\u7528\u4e8e\u6cbb\u7597III\u671fNSCLC\u4ea6\u5df2\u83b7\u7eb3\u5165\u4e2d\u534e\u533b\u5b66\u4f1a\u4e34\u5e8a\u5b9e\u8df5\u6307\u5357\uff082023\u5e74\u7248\uff09\u3002<\/p>\n<p class=\"prntal\">&nbsp;<\/p>\n<p class=\"prntal\"><b>II. \u4e0d\u65ad\u53d1\u5c55\u7684\u7ba1\u7ebf\u7684\u4e34\u5e8a\u8fdb\u5c55<\/b><\/p>\n<p class=\"prntal\">\u8be6\u60c5\u5982\u4e0b\uff1a<\/p>\n<ul type=\"disc\">\n<li><b>CS5001 (LCB71\uff0cROR1 ADC)<\/b><\/li>\n<\/ul>\n<p class=\"prnml40\">&#8211; \u672c\u6f5c\u5728\u540c\u7c7b\u6700\u4f18\uff08BIC\uff09ROR1 ADC\u7684FIH\u5168\u7403\u8bd5\u9a8c\u5df2\u8fc5\u901f\u63a8\u8fdb\u5230\u7f8e\u56fd\u3001\u6fb3\u5927\u5229\u4e9a\u53ca\u4e2d\u56fd\u5242\u91cf\u9012\u589e\u90e8\u5206\u7684\u60a3\u8005\u62db\u52df\u9636\u6bb5\u3002<\/p>\n<p class=\"prnml40\">&#8211; 2023\u5e7412\u670820\u65e5\uff0c\u6211\u4eec\u62a5\u544a\u4e86\u6b63\u5728\u8fdb\u884c\u7684FIH\u8bd5\u9a8c\u65e9\u671f\u9636\u6bb5\u7684\u521d\u6b65\u7ed3\u679c\uff0c\u5f53\u65f6\u5df2\u5b8c\u6210\u7b2c7\u7ea7\u5242\u91cf\u6c34\u5e73\u7684\u5b89\u5168\u6027\u8bc4\u4f30\u53ca\u6b63\u5728\u8fdb\u884c\u7597\u6548\u8bc4\u4f30\u3002CS5001\u5c55\u73b0\u4e86\u826f\u597d\u7684\u8010\u53d7\u6027\u548c\u5b89\u5168\u6027\uff0c\u5e76\u5728\u5b9e\u4f53\u7624\u548c\u6dcb\u5df4\u7624\u4e2d\u663e\u793a\u51fa\u826f\u597d\u7684\u6297\u80bf\u7624\u6d3b\u6027\u3002CS5001\u662f\u8fc4\u4eca\u4e3a\u6b62\u6240\u62a5\u544a\u7b2c\u4e00\u4e2a\u5bf9\u5b9e\u4f53\u7624\u5177\u6709\u4e34\u5e8a\u6297\u80bf\u7624\u6d3b\u6027\u7684ROR1 ADC\u3002<\/p>\n<p class=\"prnml40\">&#8211; \u622a\u81f3\u672c\u516c\u544a\u65e5\u671f\uff0c\u6211\u4eec\u5df2\u5c06\u5242\u91cf\u6c34\u5e73\u9012\u589e\u81f3\u7b2c9\u7ea7\u3002\u6211\u4eec\u672a\u89c2\u5bdf\u5230\u5242\u91cf\u9650\u5236\u6027\u6bd2\u6027\uff08DLT\uff09\uff1b\u4e14\u5c1a\u672a\u8fbe\u5230\u6700\u5927\u8010\u53d7\u5242\u91cf\uff08MTD\uff09\u3002\u5728\u672a\u8003\u8651ROR1\u72b6\u51b5\u7684\u60c5\u51b5\u4e0b\u5165\u7ec4\u53ca\u63a5\u53d7\u5927\u91cf\u5148\u524d\u6cbb\u7597\u7684\u6dcb\u5df4\u7624\u6216\u5b9e\u4f53\u7624\u60a3\u8005\u4e2d\uff0c\u968f\u7740\u5242\u91cf\u6c34\u5e73\u589e\u52a0\uff0cCS5001\u4fdd\u6301\u826f\u597d\u7684\u8010\u53d7\u6027\uff1b\u672a\u89c2\u5bdf\u5230\u7b2c4\u81f35\u7ea7\u6cbb\u7597\u76f8\u5173\u4e0d\u826f\u4e8b\u4ef6\u3002CS5001\u7684\u836f\u4ee3\u52a8\u529b\u5b66\uff08PK\uff09\u7279\u5f81\u7b26\u5408\u9884\u671f\uff0c\u5e76\u663e\u793aADC\u5177\u6709\u4f18\u5f02\u7684\u7a33\u5b9a\u6027\u3002\u6211\u4eec\u4ece\u7b2c5\u7ea7\u5242\u91cf\u6c34\u5e73\u5f00\u59cb\u89c2\u5bdf\u5230\u4ee4\u4eba\u9f13\u821e\u7684\u6297\u80bf\u7624\u6d3b\u6027\uff0c\u5305\u62ec\u665a\u671f\u5b9e\u4f53\u7624\uff08\u5982\u80ba\u764c\u53ca\u80f0\u817a\u764c\uff09\u53ca\u6dcb\u5df4\u7624\uff08\u5982\u970d\u5947\u91d1\u6dcb\u5df4\u7624\u53ca\u5f25\u6f2b\u6027\u5927B \u7ec6\u80de\u6dcb\u5df4\u7624\uff08DLBCL\uff09\uff09\u7684\u90e8\u5206\u53ca\u5b8c\u5168\u7f13\u89e3\u3002\u6211\u4eec\u9884\u8ba1\u5c06\u4e8e2024\u5e74\u4e0a\u534a\u5e74\u786e\u5b9aCS5001\u7684\u521d\u6b65\u63a8\u83502\u671f\u5242\u91cf\uff08RP2D\uff09\uff0c\u5e76\u8ba1\u5212\u4e8e2024\u5e74\u5e95\u524d\u542f\u52a8\u6ce8\u518c\u6027Ib\/II\u671f\u8bd5\u9a8c\u3002\u968f\u7740\u5242\u91cf\u589e\u52a0\u8fc7\u7a0b\u4e2d\u6240\u79ef\u7d2f\u7684\u6570\u636e\u8d8a\u6765\u8d8a\u4e30\u5bcc\uff0c\u6211\u4eec\u8ba1\u5212\u4e8e2024\u5e74\u5728\u56fd\u9645\u5b66\u672f\u4f1a\u8bae(\u5305\u62ecASCO\u3001ESMO\u53ca\u7f8e\u56fd\u8840\u6db2\u5b66\u4f1a\u5e74\u4f1a\uff08ASH\uff09\uff09\u4e0a\u8fdb\u884c\u591a\u6b21\u6c47\u62a5\u3002<\/p>\n<p class=\"prnml40\">&#8211; CS5001\u6709\u8bb8\u591a\u5dee\u5f02\u6027\u7279\u5f81\uff0c\u5305\u62ec\u4e13\u6709\u7684\u4f4d\u70b9\u7279\u5f02\u6027\u5076\u8054\u3001\u80bf\u7624\u9009\u62e9\u6027\u53ef\u5207\u5272\u8fde\u63a5\u5b50\u53ca\u524d\u836f\u6280\u672f\u3002\u4e0e\u53c2\u6bd4\u5177\u6709\u5355\u7532\u57fa\u6fb3\u745e\u4ed6\u6c40E\uff08MMAE\uff09\u6bd2\u7d20\u7684ROR1 ADC\u76f8\u6bd4\u8f83\uff0cCS5001\u5df2\u4e8e\u5957\u7ec6\u80de\u6dcb\u5df4\u7624\u53ca\u4e09\u9634\u6027\u4e73\u817a\u764c\u5f02\u79cd\u79fb\u690d\u6a21\u578b\u663e\u793a\u51faBIC\u6f5c\u529b\u3002\u6b64\u5916\uff0cCS5001\u5728\u4f53\u5916\u5171\u57f9\u517b\u7cfb\u7edf\u663e\u793a\u51fa\u65c1\u89c2\u8005\u6548\u5e94\uff0c\u8868\u660eROR1\u5f02\u8d28\u6027\/\u4f4e\u8868\u8fbe\u7684\u5b9e\u4f53\u7624\u4ea6\u53ef\u80fd\u53d7\u76ca\u30022023\u5e743\u6708\uff0c\u6211\u4eec\u4e8e\u7b2c13\u5c4a\u4e16\u754cADC\u4f26\u6566\u5927\u4f1a\uff08\u4e16\u754cADC\u4f26\u6566\uff09\u4e0a\u4ee5\u53e3\u5934\u6c47\u62a5\u5f62\u5f0f\u5c55\u793aCS5001\u7684\u8f6c\u5316\u6570\u636e\u3002<\/p>\n<p class=\"prnml40\">&#8211; \u6b64\u5916\uff0c\u4e3a\u786e\u4fdd\u751f\u7269\u6807\u8bb0\u7269\u9a71\u52a8\u60a3\u8005\u7684\u9009\u62e9\u4e43\u57fa\u4e8e\u80bf\u7624ROR1\u8868\u8fbe\uff0c\u6211\u4eec\u5df2\u8bc6\u522b\u6709\u6f5c\u529b\u7684\u5019\u9009ROR1 \u6297\u4f53\u514b\u9686\u7528\u4e8e\u514d\u75ab\u7ec4\u5316\uff08IHC\uff09\uff0c\u4ee5\u652f\u6301\u672a\u6765\u6709\u5173\u7cbe\u51c6\u6cbb\u7597\u836f\u7269\u7684\u5de5\u4f5c\u3002<\/p>\n<ul type=\"disc\">\n<li><b>\u8212\u683c\u5229\u5355\u6297<\/b>\uff08CS1001\uff0cPD-L1\u6297\u4f53\uff09\uff0c\u65b0\u9002\u5e94\u75c7\u6b63\u5728\u5ba1\u8bc4\u4e2d\u5e76\u6b63\u6269\u5c55\u81f3\u6b27\u6d32\u53ca\u82f1\u56fd\u3002<\/li>\n<\/ul>\n<p class=\"prnml40\"><b>&#8211; IV\u671fNSCLC\uff1a<\/b><\/p>\n<ul type=\"disc\">\n<li style=\"list-style-type: none\">\n<ul type=\"disc\">\n<li>\u5728\u5927\u4e2d\u534e\u533a\u4ee5\u5916\u7684\u5e02\u573a\uff0cIV\u671fNSCLC\u9002\u5e94\u75c7\u7684\u4e0a\u5e02\u8bb8\u53ef\u7533\u8bf7\uff08MAA\uff09\u6b63\u5728\u7531\u591a\u4e2a\u56fd\u5bb6\u53ca\u5730\u533a\u7684\u76d1\u7ba1\u673a\u6784\u5ba1\u8bc4\u30022023\u5e742\u6708\u53ca2022\u5e7412\u6708\uff0c\u8212\u683c\u5229\u5355\u6297\u8054\u5408\u5316\u7597\u4e00\u7ebf\u6cbb\u7597\u8f6c\u79fb\u6027NSCLC\u60a3\u8005\u7684MAA\u83b7\u6b27\u76dfEMA\u53ca\u82f1\u56fd\u836f\u54c1\u548c\u533b\u7597\u4fdd\u5065\u7528\u54c1\u7ba1\u7406\u5c40\uff08MHRA\uff09\u53d7\u7406\u3002\u76ee\u524d\uff0c\u6b64\u9002\u5e94\u75c7\u6b63\u7531\u53cc\u65b9\u5ba1\u8bc4\u30022023\u5e747\u6708\uff0c\u6211\u4eec\u6536\u5230\u6765\u81ea\u6b27\u76dfEMA\u5c31\u6b64\u9002\u5e94\u75c7\u8fdb\u884cGCP\u68c0\u67e5\u7684\u901a\u77e5\u30022023\u5e7410\u6708\uff0c\u6211\u4eec\u6536\u5230MHRA\u53d1\u51fa\u7684\u7b2c80\u5929\u7684\u8fdb\u4e00\u6b65\u8d44\u6599\u8981\u6c42\uff08RFI\uff09\uff0c\u5f53\u4e2d\u5e76\u65e0\u4efb\u4f55\u65e0\u6cd5\u89e3\u51b3\u7684\u95ee\u9898\u30022023\u5e7412\u6708\uff0c\u6211\u4eec\u6536\u5230EMA\u53d1\u51fa\u7684\u7b2c180\u5929\u672a\u51b3\u95ee\u9898\u6e05\u5355\uff08LoOI\uff09\uff0c\u8868\u660e\u6240\u6709\u95ee\u9898\u5df2\u4e8e\u524d\u51e0\u8f6e\u6c9f\u901a\u4e2d\u5f97\u5230\u59a5\u5584\u89e3\u51b3\u30022024\u5e742\u6708\uff0c\u6211\u4eec\u5b8c\u6210\u4e86EMA\u5728\u4e24\u4e2a\u7814\u7a76\u4e2d\u5fc3\u53caCRO\u7684GCP\u68c0\u67e5\u3002<\/li>\n<li>2023\u5e746\u6708\uff0c\u6211\u4eec\u5ba3\u5e03\u5bf9\u4e8eIV\u671fNSCLC\u60a3\u8005\u7684\u6ce8\u518c\u6027 GEMSTONE-302 \u7814\u7a76\u7684\u603b\u751f\u5b58\u671f\uff08OS\uff09\u671f\u4e2d\u5206\u6790\u7ed3\u679c\u5df2\u5728\u4e16\u754c\u77e5\u540d\u7684\u80bf\u7624\u5b66\u671f\u520a\uff0d\u300aNature Cancer\u300b\u4e0a\u53d1\u8868\u3002<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p class=\"prnml40\"><b>&#8211; GC\/GEJ<\/b><b>C<\/b><b>\uff1a<\/b><\/p>\n<ul type=\"disc\">\n<li style=\"list-style-type: none\">\n<ul type=\"disc\">\n<li>2024\u5e743\u6708\uff0c\u8212\u683c\u5229\u5355\u6297\u7528\u4e8e\u4e00\u7ebf\u6cbb\u7597\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027GC\/GEJC (CPS\u22655)\u60a3\u8005\u7684NDA\u83b7\u56fd\u5bb6\u836f\u76d1\u5c40\u6279\u51c6\u3002<\/li>\n<li>2023\u5e742\u6708\uff0c\u8212\u683c\u5229\u5355\u6297\u7528\u4e8e\u4e00\u7ebf\u6cbb\u7597\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027GC\/GEJC (CPS\u22655)\u60a3\u8005\u7684NDA\u83b7\u56fd\u5bb6\u836f\u76d1\u5c40\u53d7\u7406\u3002<\/li>\n<li>2023\u5e7410\u6708\uff0cGEMSTONE-303\u7814\u7a76\u4e2d\u7684\u9884\u8bbe\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff08PFS\uff09\u548cOS\u6700\u7ec8\u5206\u6790\u4e3b\u8981\u7814\u7a76\u7ed3\u679c\u88ab\u63a5\u6536\u4e3a\u91cd\u78c5\u6458\u8981\uff08LBA\uff09\uff0c\u5e76\u5728ESMO\u5927\u4f1a\uff082023\u5e74\uff09\u4e0a\u4ee5\u53e3\u5934\u6c47\u62a5\u5f62\u5f0f\u5c55\u793a\u3002\u4e0e\u5b89\u6170\u5242\u8054\u5408\u5316\u7597\u76f8\u6bd4\uff0c\u8212\u683c\u5229\u5355\u6297\u8054\u5408\u5316\u7597\u663e\u8457\u6539\u5584 PFS\u548cOS\uff0c\u6b64\u5dee\u5f02\u5177\u6709\u7edf\u8ba1\u5b66\u663e\u8457\u6027\u4e0e\u4e34\u5e8a\u610f\u4e49\u3002<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p class=\"prnml40\"><b>&#8211; ESCC\uff1a<\/b><\/p>\n<ul type=\"disc\">\n<li style=\"list-style-type: none\">\n<ul type=\"disc\">\n<li>2023\u5e7412\u6708\uff0c\u8212\u683c\u5229\u5355\u6297\u7528\u4e8e\u4e00\u7ebf\u6cbb\u7597\u4e0d\u53ef\u5207\u9664\u7684\u5c40\u90e8\u665a\u671f\u3001\u590d\u53d1\u6216\u8f6c\u79fb\u6027ESCC\u60a3\u8005\u7684NDA\u83b7\u56fd\u5bb6\u836f\u76d1\u5c40\u6279\u51c6\u3002<\/li>\n<li>2023\u5e744\u6708\uff0c\u8212\u683c\u5229\u5355\u6297\u7528\u4e8e\u4e00\u7ebf\u6cbb\u7597\u4e0d\u53ef\u5207\u9664\u7684\u5c40\u90e8\u665a\u671f\u3001\u590d\u53d1\u6216\u8f6c\u79fb\u6027ESCC\u60a3\u8005\u7684NDA\u83b7\u56fd\u5bb6\u836f\u76d1\u5c40\u53d7\u7406\u3002<\/li>\n<li>2023\u5e741\u6708\uff0c\u4e00\u7ebf\u6cbb\u7597\u4e0d\u53ef\u5207\u9664\u7684\u5c40\u90e8\u665a\u671f\u3001\u590d\u53d1\u6216\u8f6c\u79fb\u6027ESCC\u7684GEMSTONE-304\u7814\u7a76\u8fbe\u5230\u4e3b\u8981\u7814\u7a76\u7ec8\u70b9\u3002\u4e0e\u5b89\u6170\u5242\u8054\u5408\u5316\u7597\u76f8\u6bd4\uff0c\u8212\u683c\u5229\u5355\u6297\u8054\u5408\u5316\u7597\u660e\u663e\u6539\u5584 PFS\u548cOS\uff0c\u6b64\u5dee\u5f02\u5177\u6709\u7edf\u8ba1\u5b66\u663e\u8457\u6027\u4e0e\u4e34\u5e8a\u610f\u4e49\u3002\u6211\u4eec\u4e8e2023\u5e746\u6708\u5728ESMO GI\u5927\u4f1a\u4e0a\u516c\u5e03\u4e86\u8be5\u7814\u7a76\u7684\u8be6\u7ec6\u7ed3\u679c\u3002<\/li>\n<li>2024\u5e742\u6708\uff0c\u6ce8\u518c\u6027GEMSTONE-304\u7814\u7a76\u7684PFS\u6700\u7ec8\u5206\u6790\u7ed3\u679c\u53caOS\u671f\u4e2d\u5206\u6790\u7ed3\u679c\u520a\u53d1\u4e8e\u9876\u5c16\u533b\u5b66\u671f\u520a\u2014\u300aNature Medicine\u300b\u3002<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p class=\"prnml40\"><b>&#8211; R\/R ENKTL\uff1a<\/b><\/p>\n<ul type=\"disc\">\n<li style=\"list-style-type: none\">\n<ul type=\"disc\">\n<li>2023\u5e7410\u6708\uff0c\u8212\u683c\u5229\u5355\u6297\u7528\u4e8e\u5355\u836f\u6cbb\u7597R\/R ENKTL\u60a3\u8005\u7684NDA\u83b7\u56fd\u5bb6\u836f\u76d1\u5c40\u6279\u51c6\u3002<\/li>\n<li>2023\u5e743\u6708\uff0c R\/R ENKTL\u60a3\u8005\u7684\u6ce8\u518c\u6027GEMSTONE-201\u7814\u7a76\u7684\u7ed3\u679c\u53d1\u8868\u4e8e\u9876\u7ea7\u80bf\u7624\u5b66\u671f\u520a\uff0d\u300a\u4e34\u5e8a\u80bf\u7624\u5b66\u6742\u5fd7\u300b\u3002<\/li>\n<li>2023\u5e7412\u6708\uff0c\u6211\u4eec\u5728\u6709\u5173R\/R ENKTL\u9002\u5e94\u75c7\u6ce8\u518c\u9014\u5f84\u7684B\u7c7b\u54a8\u8be2\u65b9\u9762\u4e0e\u7f8e\u56fd\u98df\u54c1\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u8fbe\u6210\u534f\u8bae\u3002<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<ul type=\"disc\">\n<li><b>Nofazinlimab\uff08CS1003\uff0cPD-1\u6297\u4f53\uff09<\/b><\/li>\n<\/ul>\n<p class=\"prnml40\">&#8211; 2024\u5e743\u6708\uff0c\u5b8c\u6210\u4e86nofazinlimab\u8054\u5408LENVIMA<sup>&reg;<\/sup> (lenvatinib)\u4e00\u7ebf\u6cbb\u7597\u4e0d\u53ef\u5207\u9664\u6216\u8f6c\u79fb\u6027HCC\u60a3\u8005\u7684\u5168\u7403III\u671f\u8bd5\u9a8c\u7684\u9884\u8bbe\u671f\u4e2d\u5206\u6790\uff1b\u6211\u4eec\u5e76\u65e0\u89c2\u5bdf\u5230\u65b0\u589e\u6216\u610f\u5916\u5b89\u5168\u6027\u4fe1\u53f7\uff1b\u72ec\u7acb\u6570\u636e\u76d1\u5bdf\u59d4\u5458\u4f1a\uff08iDMC\uff09\u5efa\u8bae\u5728\u4e0d\u4fee\u6539\u65b9\u6848\u7684\u60c5\u51b5\u4e0b\u8fdb\u884c\u6301\u7eed\u968f\u8bbf\uff0c\u76f4\u81f3OS\u6700\u7ec8\u8bc4\u4f30\u3002<\/p>\n<p class=\"prnml40\">&#8211; 2023\u5e749\u6708\uff0c nofazinlimab\u7528\u4e8e\u6cbb\u7597\u665a\u671f\u5b9e\u4f53\u7624\u60a3\u8005\u7684FIH\u8bd5\u9a8c(CS1003-101)\u7ed3\u679c\u5df2\u53d1\u8868\u4e8e\u9ad8\u5f15\u7528\u7387\u7684\u671f\u520a\u300a\u82f1\u56fd\u764c\u75c7\u6742\u5fd7\u300b(British Journal of Cancer)\u3002<\/p>\n<ul type=\"disc\">\n<li><b>\u666e\u62c9\u66ff\u5c3c\uff08CS3009\uff0cRET\u6291\u5236\u5242\uff09<\/b><\/li>\n<\/ul>\n<p class=\"prnml40\">&#8211; 2023\u5e741\u6708\uff0c\u666e\u62c9\u66ff\u5c3c\u7528\u4e8e\u6cbb\u7597\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027RET\u878d\u5408\u9633\u6027NSCLC\u3001\u665a\u671f\u6216\u8f6c\u79fb\u6027 RET\u7a81\u53d8MTC\u53caRET\u878d\u5408\u9633\u6027TC\u60a3\u8005\u7684NDA\u83b7\u4e2d\u56fd\u53f0\u6e7e\u98df\u54c1\u836f\u7269\u7ba1\u7406\u7f72\uff08TFDA\uff09\u6279\u51c6\u3002<\/p>\n<p class=\"prnml40\">&#8211; 2023\u5e746\u6708\uff0c\u666e\u62c9\u66ff\u5c3c\u7528\u4e8e\u4e00\u7ebf\u6cbb\u7597\u5148\u524d\u672a\u63a5\u53d7\u7cfb\u7edf\u6cbb\u7597\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027RET\u878d\u5408\u9633\u6027NSCLC\u60a3\u8005\u7684NDA\u83b7\u56fd\u5bb6\u836f\u76d1\u5c40\u6279\u51c6\u3002<\/p>\n<p class=\"prnml40\">&#8211; 2023\u5e746\u6708\uff0cRET\u878d\u5408\u9633\u6027NSCLC\u4e2d\u56fd\u60a3\u8005\u7684I\/II\u671f ARROW\u8bd5\u9a8c\u7684\u6700\u65b0\u7ed3\u679c\u53d1\u8868\u4e8e\u300aCancer\u300b\u3002<\/p>\n<ul type=\"disc\">\n<li><b>\u963f\u4f10\u66ff\u5c3c\uff08CS3007\uff0cKIT\/PDGFRA<\/b><b>\u6291\u5236\u5242<\/b><b>\uff09<\/b><\/li>\n<\/ul>\n<p class=\"prnml40\">&#8211; 2023\u5e745\u6708\uff0c\u6211\u4eec\u7684\u5408\u4f5c\u4f19\u4f34Blueprint Medicines Corporation\uff08Blueprint Medicines\uff09\u5c31\u8be5\u4ea7\u54c1\u5728\u7f8e\u56fd\u83b7\u5f97\u6765\u81ea\u7f8e\u56fd\u98df\u54c1\u548c\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08FDA\uff09\u7684\u6279\u51c6\uff0c\u5c06\u5176\u7528\u4e8e\u6cbb\u7597\u60f0\u6027\u7cfb\u7edf\u6027\u80a5\u5927\u7ec6\u80de\u589e\u591a\u75c7\uff08ISM\uff09\u6210\u4eba\u60a3\u8005\u3002<\/p>\n<p class=\"prnml40\">&#8211; 2023\u5e7412\u6708\uff0c\u6211\u4eec\u7684\u5408\u4f5c\u4f19\u4f34Blueprint Medicines\u83b7\u5f97\u6765\u81ea EMA\u7684\u6279\u51c6\uff0c\u6388\u4e88\u5176\u53ef\u7528\u4e8e\u6cbb\u7597\u5728\u7cfb\u7edf\u6cbb\u7597\u4e2d\u51fa\u73b0\u4e2d\u91cd\u5ea6\u75c7\u72b6\u63a7\u5236\u4e0d\u5145\u5206\u7684\u60f0\u6027\u7cfb\u7edf\u6027\u80a5\u5927\u7ec6\u80de\u589e\u591a\u75c7\u6210\u4eba\u60a3\u8005\u3002\u8fc4\u4eca\u4e3a\u6b62\uff0c\u963f\u4f10\u66ff\u5c3c\u662f\u6b27\u6d32\u9996\u4e2a\u4ea6\u662f\u552f\u4e00\u83b7\u6279\u51c6\u7528\u4e8e\u6cbb\u7597\u60f0\u6027\u7cfb\u7edf\u6027\u80a5\u5927\u7ec6\u80de\u589e\u591a\u75c7\u60a3\u8005\u7684\u7597\u6cd5\u3002<\/p>\n<p class=\"prnml40\">&#8211; 2023\u5e746\u6708\uff0c\u963f\u4f10\u66ff\u5c3c\u7528\u4e8e\u6cbb\u7597\u665a\u671fGIST\u60a3\u8005\u7684\u65b0\u6570\u636e\u5728\u7f8e\u56fd\u4e34\u5e8a\u80bf\u7624\u5b66\u4f1a\u5e74\u4f1a\uff082023\u5e74\uff09\u4e0a\u53d1\u8868\u3002<\/p>\n<p class=\"prnml40\">&#8211; 2023\u5e7411\u6708\uff0c\u963f\u4f10\u66ff\u5c3c\u6cbb\u7597\u665a\u671fGIST\u7684\u5168\u74031\u671fNAVIGATOR\u53ca\u4e2d\u56fd\u6865\u63a51\/2\u671f(CS3007-101)\u7814\u7a76\u7684\u4e8b\u540e\u6570\u636e\u5206\u6790\u5728\u77e5\u540d\u80bf\u7624\u5b66\u671f\u520a\u300aClinical Cancer Research\u300b\u53d1\u8868\u3002<\/p>\n<ul type=\"disc\">\n<li><b>\u827e\u4f0f\u5c3c\u5e03\uff08CS3010\uff0cIDH1\u6291\u5236<\/b><b>\u5242<\/b><b>\uff09<\/b><\/li>\n<\/ul>\n<p class=\"prnml40\">&#8211; 2023\u5e7412\u6708\uff0c\u827e\u4f0f\u5c3c\u5e03\u7528\u4e8e\u6cbb\u7597R\/R AML\u7684\u5e38\u89c4\u6279\u51c6\u800c\u63d0\u4ea4\u7684\u8865\u5145\u8d44\u6599\u83b7\u56fd\u5bb6\u836f\u76d1\u5c40\u53d7\u7406\u3002<\/p>\n<p class=\"prnml40\">&#8211; 2023\u5e745\u6708\uff0c\u827e\u4f0f\u5c3c\u5e03\u7528\u4e8e\u6cbb\u7597R\/R AML\u7684\u5e38\u89c4\u6279\u51c6\u7684\u76d1\u7ba1\u9014\u5f84\u4e0e\u836f\u54c1\u5ba1\u8bc4\u4e2d\u5fc3\u8fbe\u6210\u4e00\u81f4\u3002<\/p>\n<p class=\"prnml40\">&#8211; 2023\u5e741\u6708\uff0c\u5b8c\u6210\u827e\u4f0f\u5c3c\u5e03\u5728R\/R AML\u60a3\u8005\u7684\u4e2d\u56fd\u6865\u63a5\u7814\u7a76\u3002<\/p>\n<ul type=\"disc\">\n<li><b>\u6d1b\u62c9\u66ff\u5c3c\uff08<\/b><b>ALK\/ROS-1\u6291\u5236<\/b><b>\u5242<\/b><b>\uff09<\/b><\/li>\n<\/ul>\n<p class=\"prnml40\">&#8211; \u6211\u4eec\u6b63\u9488\u5bf9\u5148\u524d\u7ecf\u514b\u5511\u66ff\u5c3c\u53ca\u542b\u94c2\u5316\u7597\u540e\u7684ROS1 \u9633\u6027\u665a\u671fNSCLC\u60a3\u8005\u8fdb\u884c\u5173\u952e\u7814\u7a76\u30022023\u5e746\u6708\uff0c\u6211\u4eec\u5c31\u8be5\u9879\u7814\u7a76\u5b8c\u6210\u4e86\u60a3\u8005\u5165\u7ec4\u30022024\u5e742\u6708\uff0c\u8be5\u5173\u952e\u7814\u7a76\u8fbe\u5230\u4e3b\u8981\u7ec8\u70b9\uff0c\u6211\u4eec\u6b63\u5728\u4e0e\u836f\u54c1\u5ba1\u8bc4\u4e2d\u5fc3\u53ca\u8f89\u745e\u5c31\u4e8e2024\u5e74\u5728\u4e2d\u56fd\u5927\u9646\u63d0\u4ea4ROS1\u9633\u6027\u665a\u671fNSCLC\u7684pre-NDA\/NDA\u8fdb\u884c\u8ba8\u8bba\u3002<\/p>\n<p class=\"prntal\">&nbsp;<\/p>\n<p class=\"prntal\"><b>III. \u5229\u7528\u591a\u79cd\u521b\u65b0\u6e20\u9053\u5efa\u7acb\u7814\u7a76\u7ba1\u7ebf<\/b><\/p>\n<p class=\"prntal\">\u7cbe\u51c6\u6cbb\u7597\u836f\u7269\u53ca\u514d\u75ab\u80bf\u7624\u836f\u7269\u8054\u5408\u6cbb\u7597\u4ecd\u7136\u662f\u6211\u4eec\u7684\u6218\u7565\u91cd\u70b9\u3002\u5c06\u7ec6\u80de\u6bd2\u6027\u836f\u7269\u7cbe\u786e\u5730\u8f93\u9001\u5230\u80bf\u7624\u7684ADC\uff0c\u4ee5\u53ca\u53ef\u521b\u9020\u65b0\u751f\u7269\u5b66\u53ca\u7ec4\u5408\u7684\u591a\u7279\u5f02\u6027\u751f\u7269\u5236\u54c1\u4ee3\u8868\u4e24\u79cd\u65e9\u671f\u5f00\u53d1\u7684\u77ed\u671f\u6a21\u5f0f\u3002<\/p>\n<p class=\"prntal\">2023\u5e74\uff0c\u6211\u4eec\u5df2\u901a\u8fc7\u82e5\u5e72\u4e3e\u63aa\u53d6\u5f97\u91cd\u5927\u8fdb\u5c55\uff1a<\/p>\n<ul type=\"disc\">\n<li><b>\u540c\u7c7b\u9996\u521b<\/b><b>\/<\/b><b>\u540c\u7c7b\u6700\u4f18\uff08<\/b><b>FIC\/BIC\uff09ADC\uff1a<\/b>\u4e24\u4e2a\u540c\u7c7b\u9996\u521bADC\u9879\u76ee\u6b63\u5728\u5411\u5b8c\u6210\u4e34\u5e8a\u5019\u9009\u5206\u5b50\u7684\u7b5b\u9009\u9636\u6bb5\u63a8\u8fdb\u3002\u5176\u4e2d\u4e00\u4e2a\u9488\u5bf9\u591a\u79cd\u9ad8\u53d1\u80bf\u7624\u9002\u5e94\u75c7\u5e76\u91c7\u7528\u5185\u90e8\u673a\u5668\u5b66\u4e60\u751f\u7269\u4fe1\u606f\u5b66\u7b97\u6cd5\u8bc6\u522b\u7684\u65b0\u578b\u80bf\u7624\u76f8\u5173\u6297\u539f\u7684ADC\u9879\u76eeCS5006\u9884\u8ba1\u5c06\u4e8e2024\u5e74\u4e0a\u534a\u5e74\u5b8c\u6210\u4e34\u5e8a\u524d\u5019\u9009\u5206\u5b50\u7684\u7b5b\u9009\u3002\u53e6\u5916\uff0c\u53e6\u4e00\u540c\u7c7b\u9996\u521bGPCR-x ADC CS5005\u7684\u5148\u5bfc\u6297\u4f53\u5df2\u9009\u5b9a\u3002\u5171\u8f6d\u5148\u5bfc\u5206\u5b50\u5728\u4f53\u5916\u53ca\u4f53\u5185\u5747\u8868\u73b0\u51fa\u4ee4\u4eba\u9f13\u821e\u7684\u7597\u6548\uff1b\u9884\u8ba1\u8be5\u4e24\u79cd\u540c\u7c7b\u9996\u521bADC\u5c06\u4e8e\u4e8c\u96f6\u4e8c\u4e94\u5e74\u63d0\u4ea4\u76f8\u5173\u6ce8\u518c\u6027\u65b0\u836f\u4e0a\u5e02\u7533\u8bf7\uff08IND\uff09\u3002\u6b64\u5916\uff0cCS5007\uff08\u9884\u8ba1\u5c06\u6210\u4e3a\u540c\u7c7b\u6700\u4f18\u7279\u5f02\u6027ADC\uff09\u53ca\u5176\u76f8\u5e94\u7684\u7279\u5f02\u6027\u6297\u4f53CS2011\uff0c\u6b63\u5728\u5411\u4e34\u5e8a\u524d\u5019\u9009\u836f\u7269\u9636\u6bb5\u63a8\u8fdb\u3002CS5007\uff08CS2011\uff09\u9776\u5411\u7ecf\u8fc7\u9a8c\u8bc1\u7684\u9776\u70b9\uff0c\u5177\u6709\u7ecf\u8bc1\u5b9e\u7684\u540c\u6e90\u6709\u6548\u6027\u3002\u9884\u8ba1\u5c06\u4e8e2024\u5e74\u4e0a\u534a\u5e74\u5b8c\u6210\u5173\u952e\u7684\u53cc\u7279\u5f02\u6027\u6297\u4f53\u5019\u9009\u5206\u5b50\u7684\u7b5b\u9009\uff0c\u4e14\u9884\u8ba1\u5c06\u4e8e2024\u5e74\u5e95\u5ba3\u5e03\u8be5\u53cc\u7279\u5f02\u6027ADC\u5b8c\u6210\u4e34\u5e8a\u524d\u5019\u9009\u836f\u7269\u7684\u7b5b\u9009\u3002<\/li>\n<li><b>\u514d\u75ab\u80bf\u7624\u591a\u7279\u5f02\u6027\u6297\u4f53\uff1a<\/b>CS2009\u4e3a\u9488\u5bf9PD-1\u3001VEGFa\u53caCTLA-4\u9776\u70b9\u7684\u4e09\u7279\u5f02\u6027\u5206\u5b50\uff0c\u6b63\u5904\u4e8e\u7ec6\u80de\u682a\u5f00\u53d1\u9636\u6bb5\uff0c\u4e14\u76f8\u5173IND\u9884\u8ba1\u4e8e2024\u5e74\u63d0\u4ea4\u3002\u8fd9\u662f\u4e00\u79cd\u6f5c\u5728\u7684\u540c\u7c7b\u9996\u521b\u4e0b\u4e00\u4ee3\u80bf\u7624\u514d\u75ab\u9aa8\u67b6\u4ea7\u54c1\uff0c\u5176\u9776\u5411\u80bf\u7624\u5fae\u73af\u5883\u4e2d\u7684\u4e09\u4e2a\u5173\u952e\u514d\u75ab\u6291\u5236\u9014\u5f84\uff0c\u5e76\u53ef\u52a0\u6df1\u57fa\u4e8ePD-(L)1\u7597\u6cd5\u6cbb\u7597\u9ad8\u53d1\u80bf\u7624\u7c7b\u578b\uff08\u5305\u62ecNSCLC\u53caHCC\uff09\u7684\u7597\u6548\u3002<\/li>\n<li><b>\u7ec6\u80de\u7a7f\u900f\u6cbb\u7597\u5e73\u53f0\uff1a<\/b>\u8bb8\u591a\u4f17\u6240\u5468\u77e5\u7684\u80bf\u7624\u5b66\u9776\u70b9\u662f\u73b0\u6709\u6cbb\u7597\u65b9\u6cd5\u8ba4\u4e3a\u4e0d\u53ef\u6210\u836f\u7684\u7ec6\u80de\u5185\u86cb\u767d\u3002\u6211\u4eec\u6b63\u5728\u9488\u5bf9\u8be5\u7b49\u96be\u6cbb\u6027\u9776\u70b9\u5f00\u53d1\u4e00\u79cd\u4e13\u6709\u7684\u7ec6\u80de\u7a7f\u900f\u6cbb\u7597\u5e73\u53f0\u3002\u8be5\u5e73\u53f0\u7684\u5f00\u53d1\u5df2\u53d6\u5f97\u91cd\u5927\u8fdb\u5c55\uff0c\u5177\u6709\u9488\u5bf9\u80bf\u7624\u53ca\u5176\u4ed6\u75be\u75c5\u7684\u5e7f\u6cdb\u6cbb\u7597\u6f5c\u529b\u3002<\/li>\n<\/ul>\n<p class=\"prntal\">&nbsp;<\/p>\n<p class=\"prntal\"><b>IV. \u6218\u7565\u5173\u7cfb\u4fc3\u8fdb\u5546\u4e1a\u5316\u6d3b\u52a8\u53ca\u7ba1\u7ebf\u5f00\u53d1<\/b><\/p>\n<p class=\"prntal\">\u6211\u4eec\u4e0d\u65ad\u53d1\u5c55\u4e0e\u6df1\u5316\u4e0e\u5168\u7403\u4e3b\u8981\u6218\u7565\u5408\u4f5c\u4f19\u4f34\uff08\u5305\u62ec\u4e2d\u56fd\u7684\u5408\u4f5c\u4f19\u4f34\uff09\u7684\u5173\u7cfb\uff0c\u6269\u5c55\u5df2\u4e0a\u5e02\u53ca\u665a\u671f\u836f\u7269\u7684\u5546\u4e1a\u5316\uff0c\u5de9\u56fa\u6211\u4eec\u6f5c\u5728\u540c\u7c7b\u9996\u521b\/\u540c\u7c7b\u6700\u4f18\u5206\u5b50\u7684\u65e9\u671f\u4ea7\u54c1\u7ba1\u7ebf\uff0c\u83b7\u53d6\u66f4\u591a\u80fd\u591f\u52a0\u5f3a\u6211\u4eec\u7814\u53d1\u5b9e\u529b\u7684\u6280\u672f\u3002<\/p>\n<p class=\"prntal\">2023\u5e7411\u6708\uff0c\u6211\u4eec\u4e0e\u4e09\u751f\u5236\u836f\u5c31nofazinlimab\u8fbe\u6210\u5728\u4e2d\u56fd\u5927\u9646\u7684\u6218\u7565\u5408\u4f5c\uff0c\u5e76\u6388\u4e88\u4e09\u751f\u5236\u836f\u5728\u4e2d\u56fd\u5927\u9646\u5f00\u53d1\u3001\u6ce8\u518c\u3001\u751f\u4ea7\u548c\u5546\u4e1a\u5316nofazinlimab\u7684\u72ec\u5bb6\u6743\u5229\u3002\u8be5\u5408\u4f5c\u4f19\u4f34\u5173\u7cfb\u5c06\u52a0\u5febnofazinlimab\u7684CMC\u5f00\u53d1\u53ca\u5546\u4e1a\u5316\u3002<\/p>\n<p class=\"prntal\">2023\u5e7411\u6708\uff0c\u6211\u4eec\u4e0e\u827e\u529b\u65af\u5728\u4e2d\u56fd\u5c31\u666e\u62c9\u66ff\u5c3c\u7684\u63a8\u5e7f\u53ca\u4e0a\u5e02\u8fbe\u6210\u5546\u4e1a\u5408\u4f5c\u4f19\u4f34\u5173\u7cfb\u3002\u8be5\u4ea4\u6613\u5c06\u666e\u62c9\u66ff\u5c3c\u7eb3\u5165\u827e\u529b\u65af\u7684\u9ad8\u5ea6\u534f\u540c\u80ba\u764c\u4e1a\u52a1\u90e8\uff0c\u5e76\u4f7f\u666e\u62c9\u66ff\u5c3c\u53d7\u76ca\u4e8e\u827e\u529b\u65af\u66f4\u6210\u719f\u7684\u5546\u4e1a\u56e2\u961f\u53ca\u66f4\u5927\u7684\u5e02\u573a\u8986\u76d6\u8303\u56f4\uff0c\u540c\u65f6\u4f7f\u57fa\u77f3\u836f\u4e1a\u80fd\u591f\u51cf\u5c11\u4e0e\u666e\u62c9\u66ff\u5c3c\u5546\u4e1a\u5316\u76f8\u5173\u7684\u7ecf\u8425\u8d39\u7528\u53ca\u8fd0\u8425\u6210\u672c\uff0c\u4ece\u800c\u63d0\u9ad8\u6574\u4f53\u76c8\u5229\u80fd\u529b\u3002<\/p>\n<p class=\"prntal\">2023\u5e7412\u6708\uff0c\u6211\u4eec\u5c06\u827e\u4f0f\u5c3c\u5e03\u5728\u5927\u4e2d\u534e\u533a\u53ca\u65b0\u52a0\u5761\u7684\u6743\u5229\u8f6c\u8ba9\u4e88\u5168\u7403\u8bb8\u53ef\u8bc1\u6301\u6709\u4eba\u65bd\u7ef4\u96c5\uff0c\u8f6c\u8ba9\u4ef7\u6700\u591a\u4e3a5\u5343\u4e07\u7f8e\u5143\uff08\u5305\u62ec\u9996\u4ed8\u6b3e4400\u4e07\u7f8e\u5143\uff08\u8f6c\u8ba9\u827e\u4f0f\u5c3c\u5e03\u4e1a\u52a1\uff09\uff09\u3002\u6b64\u9879\u9ad8\u589e\u503c\u4ea4\u6613\u4f7f\u57fa\u77f3\u836f\u4e1a\u80fd\u591f\u6536\u56de\u5176\u5bf9\u8be5\u8d44\u4ea7\u7684\u521d\u59cb\u6295\u8d44\uff0c\u5e76\u53d8\u73b0\u8be5\u4e1a\u52a1\u7684\u672a\u6765\u6f5c\u5728\u73b0\u91d1\u6d41\u3002<\/p>\n<p class=\"prntal\">\u6839\u636e\u6211\u4eec\u4e0e\u6c5f\u82cf\u6052\u745e\u533b\u836f\u80a1\u4efd\u6709\u9650\u516c\u53f8\uff08\u6052\u745e\uff09\u5c31\u6297CTLA-4 \u5355\u514b\u9686\u6297\u4f53 (CS1002)\u5efa\u7acb\u7684\u5408\u4f5c\u5173\u7cfb\uff0c\u6052\u745e\u6b63\u5728\u8fdb\u884c\u5173\u4e8eCS1002\u8054\u5408\u7597\u6cd5\u7528\u4e8e\u6cbb\u7597\u665a\u671f\u5b9e\u4f53\u7624\uff08\u5305\u62ecHCC\u53caNSCLC\uff09\u7684Ib\/II\u671f\u8bd5\u9a8c\u3002\u76ee\u524d\uff0c\u8be5\u8bd5\u9a8c\u6b63\u5728\u987a\u5229\u62db\u52df\u60a3\u8005\u30022024\u5e741\u6708\uff0c\u6052\u745e\u5c31\u8bc4\u4f30CS1002(SHR-8068)\u8054\u5408adebrelimab\u53ca\u5316\u7597\u7528\u4e8e\u4e00\u7ebf\u6cbb\u7597\u665a\u671f\u6216\u8f6c\u79fb\u6027\u975e\u9cde\u72b6NSCLC\u60a3\u8005\u7684\u7597\u6548\u53d6\u5f97\u56fd\u5bb6\u836f\u76d1\u5c40\u7684 IND\u6279\u51c6\u3002<\/p>\n<p class=\"prntal\">\u968f\u7740\u57fa\u77f3\u836f\u4e1a\u4e0eEQRx\u5c31\u8212\u683c\u5229\u5355\u6297\u53canofazinlimab\u8ba2\u7acb\u7684\u6388\u6743\u534f\u8bae\u4e8e2023\u5e745\u67089\u65e5\u7ec8\u6b62\uff0c\u6211\u4eec\u91cd\u65b0\u83b7\u5f97\u8212\u683c\u5229\u5355\u6297\u53canofazinlimab\u4e8e\u5927\u4e2d\u534e\u533a\u4ee5\u5916\u5730\u533a\u7684\u5f00\u53d1\u53ca\u5546\u4e1a\u5316\u6743\u5229\u3002\u6709\u5173\u6743\u5229\u8fc7\u6e21\u5df2\u4e8e2023\u5e748\u6708\u5b8c\u6210\u3002\u6211\u4eec\u76ee\u524d\u6b63\u4e3b\u5bfc\u914d\u5408EMA\u53ca\u82f1\u56fdMHRA\u5bf9\u8212\u683c\u5229\u5355\u6297\u8fdb\u884cMAA\u5ba1\u67e5\u7684\u76d1\u7ba1\u6d41\u7a0b\u3002\u7ec8\u6b62\u8be5\u6388\u6743\u534f\u8bae\u5c06\u4e0d\u4f1a\u5f71\u54cd\u5148\u524d\u81eaEQRx\u6536\u53d6\u7684\u9996\u4ed8\u6b3e\u53ca\u91cc\u7a0b\u7891\u4ed8\u6b3e\u3002\u6211\u4eec\u76ee\u524d\u6b63\u5728\u5bfb\u6c42\u8212\u683c\u5229\u5355\u6297\u53canofazinlimab\u4e8e\u5927\u4e2d\u534e\u533a\u4ee5\u5916\u5730\u533a\u7684\u6f5c\u5728\u5408\u4f5c\u673a\u4f1a\u3002<\/p>\n<p class=\"prntal\">&nbsp;<\/p>\n<p class=\"prntal\"><b>V. \u5176\u4ed6\u4e1a\u52a1\u8fdb\u5c55<\/b><\/p>\n<p class=\"prntal\"><b>\u751f\u4ea7\uff1a<\/b>\u6211\u4eec\u4e5f\u6b63\u5728\u8fdb\u884c\u591a\u6b3e\u8fdb\u53e3\u4ea7\u54c1\u7684\u6280\u672f\u8f6c\u79fb\uff0c\u8fd9\u5c06\u6709\u52a9\u4e8e\u964d\u4f4e\u6210\u672c\uff0c\u63d0\u9ad8\u6211\u4eec\u4ea7\u54c1\u7684\u957f\u671f\u76c8\u5229\u80fd\u529b\u3002\u5177\u4f53\u800c\u8a00\uff0c\u6709\u5173\u963f\u4f10\u66ff\u5c3c\u7684\u6280\u672f\u8f6c\u79fb\u7533\u8bf7\u6b63\u5728\u836f\u54c1\u5ba1\u8bc4\u4e2d\u5fc3\u5ba1\u6838\u4e2d\u3002\u540c\u65f6\uff0c\u666e\u62c9\u66ff\u5c3c\u7684\u6280\u672f\u8f6c\u79fb\uff08\u5305\u62ec\u751f\u4ea7\u53ca\u4e34\u5e8a\u751f\u7269\u7b49\u6548\u6027\u7814\u7a76\uff09\u5df2\u6210\u529f\u5b8c\u6210\uff0c\u7533\u8bf7\u8d44\u6599\u5df2\u63d0\u4ea4\u4e88CDE\u3002<\/p>\n<p class=\"prntal\">&nbsp;<\/p>\n<p class=\"prntal\"><b>\u672a\u6765\u53ca\u613f\u666f<\/b><\/p>\n<p class=\"prntal\">\u5c55\u671b\u672a\u6765\uff0c\u6211\u4eec\u5c06\u7ee7\u7eed\u63a8\u8fdb\u521b\u65b0\u7ba1\u7ebf\u836f\u7269\uff0c\u5e76\u6700\u5927\u9650\u5ea6\u5730\u53d1\u6325\u6210\u719f\u836f\u7269\u7684\u5546\u4e1a\u4ef7\u503c\u3002<\/p>\n<p class=\"prntal\">\u9884\u671f\u7684\u8fd1\u671f\u50ac\u5316\u5242\u7ec6\u8282\u8f7d\u5217\u5982\u4e0b\uff1a<\/p>\n<ul type=\"disc\">\n<li>\u8212\u683c\u5229\u5355\u6297\uff1a2024\u5e74\u4e0a\u534a\u5e74\u4eba\u7528\u533b\u836f\u4ea7\u54c1\u59d4\u5458\u4f1a\uff08CHMP\uff09\u5c31\u5728\u6b27\u76df\u7528\u4e8e\u4e00\u7ebf\u6cbb\u7597IV\u671fNSCLC\u5411MAA\u63d0\u4f9b\u610f\u89c1\uff0c\u5e76\u4e8e2024\u5e74\u4e0b\u534a\u5e74\u83b7\u5f97MAA\u6279\u51c6\uff1b2024\u5e74\u4e0b\u534a\u5e74\u5728\u82f1\u56fd\u83b7\u5f97\u7528\u4e8e\u4e00\u7ebf\u6cbb\u7597IV\u671fNSCLC\u7684 MAA\u6279\u51c6\uff1b\u4e2d\u56fd\u4ee5\u5916\u5730\u533a\u5408\u4f5c\u5173\u7cfb\u7684\u63a2\u7d22\u3002<\/li>\n<li>\u6d1b\u62c9\u66ff\u5c3c\uff1a2024\u5e74\u5728\u4e2d\u56fd\u5927\u9646\u7528\u4e8e\u6cbb\u7597ROS 1\u9633\u6027\u665a\u671fNSCLC\u7684pre-NDA\/NDA<\/li>\n<li>\u963f\u4f10\u66ff\u5c3c\uff1a\u9884\u671f2024\u5e74\u4e0b\u534a\u5e74\u672c\u5730\u5316\u751f\u4ea7\u7684\u539f\u7814\u8f6c\u5730\u4ea7\u7533\u62a5\uff08ANDA\uff09\u83b7\u6279\u51c6<\/li>\n<li>\u666e\u62c9\u66ff\u5c3c\uff1a\u9884\u671f2024\u5e74\u4e0a\u534a\u5e74\u672c\u5730\u5316\u751f\u4ea7\u7684ANDA\u83b7\u53d7\u7406<\/li>\n<li>Nofazinlimab\uff1a2025\u5e74OS\u7684\u6700\u7ec8\u5206\u6790\u7ed3\u679c\u53ca\u4e2d\u56fd\u4ee5\u5916\u5730\u533a\u5408\u4f5c\u5173\u7cfb\u7684\u63a2\u7d22<\/li>\n<li>CS5001\uff1a\u5728\u56fd\u9645\u5b66\u672f\u4f1a\u8bae\uff08\u59822024\u5e74\u4e0a\u534a\u5e74\u7684ASCO\u53ca2024\u5e74\u4e0b\u534a\u5e74\u7684ESMO\/ASH\uff09\u4e0a\u62ab\u9732\u6700\u65b0\u7684\u4e34\u5e8a\u5b89\u5168\u6027\u53ca\u7597\u6548\u6570\u636e\uff1b\u4e8e2024\u5e74\u542f\u52a8\u6ce8\u518c\u6027\u7814\u7a76\uff1b\u9884\u8ba1\u5c06\u4e8e2024\u5e74\u62162025\u5e74\u8fbe\u6210\u5168\u7403BD\u5408\u4f5c\u5173\u7cfb<\/li>\n<li>CS2009\uff1a2024\u5e74\u5e95\u524d\u5411\u6fb3\u5927\u5229\u4e9a\u4eba\u7c7b\u7814\u7a76\u4f26\u7406\u59d4\u5458\u4f1a\uff08HREC\uff09\u63d0\u4ea4\u7533\u8bf7\u4e34\u5e8a\u8bd5\u9a8c\u901a\u77e5\uff08CTN\uff09\uff0c\u5e76\u4e8e2025\u5e74\u7b2c\u4e00\u5b63\u5ea6\u63d0\u4ea4\u4e2d\u56fdIND\u7533\u8bf7<\/li>\n<li>CS5006\uff1a2024\u5e74\u4e0a\u534a\u5e74\u5b8c\u6210\u4e34\u5e8a\u524d\u5019\u9009\u5206\u5b50\u7684\u7b5b\u9009\uff0c\u5e76\u9884\u8ba1\u4e8e2025\u5e74\u63d0\u4ea4IND\u7533\u8bf7<\/li>\n<li>CS5005\uff1a2024\u5e74\u5b8c\u6210\u4e34\u5e8a\u524d\u5019\u9009\u5206\u5b50\u7684\u7b5b\u9009\uff0c\u5e76\u9884\u671f\u4e8e2025\u5e74\u63d0\u4ea4IND\u7533\u8bf7<\/li>\n<\/ul>\n<p class=\"prntal\">&nbsp;<\/p>\n<p class=\"prntal\"><b>\u8d22\u52a1\u6458\u8981<\/b><\/p>\n<p class=\"prntal\"><b>\u56fd\u9645\u8d22\u52a1\u62a5\u544a\u51c6\u5219\u8ba1\u91cf\uff1a<\/b><\/p>\n<ul 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More<\/a><\/p>\n","protected":false},"author":556,"featured_media":0,"comment_status":"close","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1965],"tags":[],"class_list":["post-109417","post","type-post","status-publish","format-standard","hentry","category-partnerships"],"amp_enabled":true,"_links":{"self":[{"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/posts\/109417","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/users\/556"}],"replies":[{"embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/comments?post=109417"}],"version-history":[{"count":1,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/posts\/109417\/revisions"}],"predecessor-version":[{"id":109418,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/posts\/109417\/revisions\/109418"}],"wp:attachment":[{"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/media?parent=109417"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/categories?post=109417"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/tags?post=109417"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}