{"id":109407,"date":"2024-03-27T21:34:00","date_gmt":"2024-03-27T14:34:00","guid":{"rendered":"https:\/\/www.xinwengao.com\/cn\/pr\/20240327213400109407"},"modified":"2024-03-28T11:53:16","modified_gmt":"2024-03-28T03:53:16","slug":"%e4%ba%9a%e7%9b%9b%e5%8c%bb%e8%8d%af2023%e5%b9%b4%e4%b8%9a%e7%bb%a9%ef%bc%9a%e5%95%86%e4%b8%9a%e5%8c%96%e8%83%bd%e5%8a%9b%e6%8c%81%e7%bb%ad%e5%a2%9e%e5%bc%ba%ef%bc%8c%e5%85%a8%e7%90%83%e4%b8%b4","status":"publish","type":"post","link":"https:\/\/www.xinwengao.com\/cn\/pr\/20240327213400109407","title":{"rendered":"\u4e9a\u76db\u533b\u836f2023\u5e74\u4e1a\u7ee9\uff1a\u5546\u4e1a\u5316\u80fd\u529b\u6301\u7eed\u589e\u5f3a\uff0c\u5168\u7403\u4e34\u5e8a\u5f00\u53d1\u8fce\u6536\u83b7\u671f"},"content":{"rendered":"\n\n\n
\"\"<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

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\u79c9\u627f”\u89e3\u51b3\u4e2d\u56fd\u4e43\u81f3\u5168\u7403\u60a3\u8005\u5c1a\u672a\u6ee1\u8db3\u7684\u4e34\u5e8a\u9700\u6c42”\u7684\u4f7f\u547d\uff0c\u4e9a\u76db\u533b\u836f\u6253\u9020\u4e86\u4e00\u6761\u5177\u6709”First-in-class”\u4e0e”Best-in-class”\u6f5c\u529b\u7684\u4e30\u5bcc\u7684\u4ea7\u54c1\u7ba1\u7ebf\uff0c\u6b63\u5728\u4e2d\u56fd\u3001\u7f8e\u56fd\u3001\u6fb3\u5927\u5229\u4e9a\u3001\u6b27\u6d32\u53ca\u52a0\u62ff\u5927\u5f00\u5c5540\u591a\u9879\u4e34\u5e8a\u8bd5\u9a8c\u3002\u591a\u4e2a\u7ba1\u7ebf\u54c1\u79cd\u7684\u6cbb\u7597\u6f5c\u529b\u88ab\u4e0d\u65ad\u6316\u6398\u9a8c\u8bc1\uff0c\u5728\u5404\u5927\u56fd\u9645\u5b66\u672f\u4f1a\u8bae\u6301\u7eed\u62ab\u9732\u4e34\u5e8a\u6570\u636e\uff0c\u5145\u5206\u4f53\u73b0\u4e86\u56fd\u9645\u5b66\u672f\u754c\u5bf9\u516c\u53f8\u521b\u65b0\u4e0e\u4e34\u5e8a\u5f00\u53d1\u80fd\u529b\u7684\u9ad8\u5ea6\u8ba4\u53ef\u3002<\/p>\n

\u7b2c65\u5c4a\u7f8e\u56fd\u8840\u6db2\u5b66\u4f1a\uff082023 ASH\uff09\u5e74\u4f1a\u4e0a\uff0c\u4e9a\u76db\u533b\u836f\u4e24\u5927\u6838\u5fc3\u54c1\u79cd\u8010\u7acb\u514b®<\/sup>\u53caAPG-2575\u7684\u591a\u9879\u6700\u65b0\u7814\u7a76\u8fdb\u5c55\u5165\u9009\u5c55\u793a\uff0c\u5f70\u663e\u7740\u516c\u53f8\u5728\u8840\u6db2\u80bf\u7624\u9886\u57df\u4e0d\u65ad\u63d0\u5347\u7684\u7ade\u4e89\u58c1\u5792\u3002<\/p>\n

\u5176\u4e2d\uff0c\u8010\u7acb\u514b®<\/sup>\u4e24\u9879\u7814\u7a76\u5165\u9009\u53e3\u5934\u62a5\u544a\uff0c\u8fd9\u662f\u8be5\u54c1\u79cd\u8fde\u7eed\u7b2c\u516d\u5e74\u83b7ASH\u5e74\u4f1a\u53e3\u5934\u62a5\u544a\u3002\u53e3\u5934\u62a5\u544a\u4e4b\u4e00\u7684\u662f\u4e00\u9879\u65e8\u5728\u8bc4\u4f30\u8010\u7acb\u514b®<\/sup>\u5bf9\u6bd4\u73b0\u6709\u6700\u4f73\u53ef\u7528\u7597\u6cd5\uff08BAT\uff09\u5728\u65e2\u5f80TKIs\u8010\u836f\u548c\/\u6216\u4e0d\u8010\u53d7\u7684CML-CP\u60a3\u8005\u4e2d\u7684\u7597\u6548\u4e0e\u5b89\u5168\u6027\u7684\u6ce8\u518cII\u671f\u7814\u7a76\u3002\u6570\u636e\u663e\u793a\uff0c\u8010\u7acb\u514b®<\/sup>\u5bf9\u6bd4BAT\u5bf9\u7167\u7ec4\uff0c\u663e\u8457\u6539\u5584\u4e86CML\u60a3\u8005\u7684\u4e34\u5e8a\u9884\u540e\uff1b\u53e6\u4e00\u9879\u53e3\u5934\u62a5\u544a\u4e3a\u6cbb\u7597\u521d\u6cbbPh+ ALL\u60a3\u8005\u7684II\u671f\u4e34\u5e8a\u8bd5\u9a8c\u65e9\u671f\u7ed3\u679c\uff0c\u8363\u767b”Highlights of ASH”\uff0c\u6570\u636e\u5448\u73b0\u51fa\u5353\u8d8a\u7597\u6548\u548c\u5b89\u5168\u6027\uff0c\u6709\u671b\u63a8\u52a8Ph+ ALL\u6cbb\u7597\u8fdb\u5165”\u65e0\u5316\u7597”\u65f6\u4ee3\u3002<\/p>\n

\u800c\u7ee72022\u5e74\u5728ASH\u5e74\u4f1a\u4e0a\u53e3\u5934\u62a5\u544a\u8010\u7acb\u514b®<\/sup>\u6d77\u5916\u7814\u7a76\u7684\u521d\u6b65\u6570\u636e\u540e\uff0c\u901a\u8fc7\u66f4\u5927\u6837\u672c\u91cf\u60a3\u8005\u7684\u6570\u636e\uff0c\u4e9a\u76db\u533b\u836f\u57282023 ASH\u5e74\u4f1a\u4e0a\u8fdb\u4e00\u6b65\u9a8c\u8bc1\u4e86\u8be5\u54c1\u79cd\u5355\u836f\u6216\u8054\u5408\u6cbb\u7597\u5728\u524d\u671f\u7ecf\u6df1\u5ea6\u6cbb\u7597\u7684CML\u6216Ph+ ALL\u60a3\u8005\u4e2d\u7597\u6548\u4e0e\u8010\u53d7\u6027\u4ff1\u4f73\uff0c\u5c24\u5176\u662f\u5728\u7ecf\u7b2c\u4e09\u4ee3TKI ponatinib\u6216\u53d8\u6784\u6291\u5236\u5242asciminib\u6cbb\u7597\u5931\u8d25\u7684\u60a3\u8005\u4e2d\u7597\u6548\u663e\u8457\uff0c\u518d\u6b21\u9a8c\u8bc1\u4e86\u8010\u7acb\u514b®<\/sup>\u4e3a\u5168\u7403\u5c42\u9762”Best-in-class”\u836f\u7269\uff0c\u6709\u671b\u4e3a\u5168\u7403CML\u6216Ph+ ALL\u60a3\u8005\u63d0\u4f9b\u65b0\u7684\u6709\u6548\u6cbb\u7597\u65b9\u6848\u3002<\/p>\n

\u57282023 ASH\u5e74\u4f1a\u4e0a\uff0c\u4e9a\u76db\u533b\u836f\u5c55\u793a\u4e86APG-2575\u7684\u4e09\u9879\u4e34\u5e8a\u7814\u7a76\u8fdb\u5c55\uff0c\u6d89\u53caCLL\u3001AML\u548c\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\uff08MM\uff09\u4e09\u4e2a\u9886\u57df\u3002\u5176\u4e2d\u6cbb\u7597\u590d\u53d1\/\u96be\u6cbb\uff08R\/R\uff09CLL\u7684\u7814\u7a76\u6570\u636e\u518d\u4e00\u6b21\u4f53\u73b0\u4e86\u8be5\u54c1\u79cd\u5f3a\u52b2\u7684\u7597\u6548\u548c\u5b89\u5168\u6027\u4f18\u52bf\u3002\u503c\u5f97\u4e00\u63d0\u7684\u662f\uff0cAPG-2575\u5728\u8be5\u4f1a\u8bae\u4e0a\u5c55\u793a\u7684MM\u53caAML\u4e34\u5e8a\u6570\u636e\u5747\u4e3a\u9996\u6b21\u62ab\u9732\uff0c\u4f53\u73b0\u51faAPG-2575\u8fd9\u4e00\u5168\u7403”Best-in-class”\u6f5c\u529b\u54c1\u79cd\u5f3a\u52b2\u7684\u6cbb\u7597\u6f5c\u529b\uff0c\u4e3a\u8be5\u54c1\u79cd\u5728\u9664CLL\u4e4b\u5916\u7684\u591a\u9002\u5e94\u75c7\u9886\u57df\u7684\u8fdb\u4e00\u6b65\u63a2\u7d22\u4e0e\u5f00\u53d1\u5960\u5b9a\u4e86\u575a\u5b9e\u57fa\u7840\u3002<\/p>\n

\u4e9a\u76db\u533b\u836f\u6b64\u524d\u8fd8\u5728\u7b2c59\u5c4a\u7f8e\u56fd\u4e34\u5e8a\u80bf\u7624\u5b66\u4f1a\uff082023 ASCO\uff09\u5e74\u4f1a\u4e0a\u5c55\u793a\u4e86\u8010\u7acb\u514b®<\/sup>\u3001APG-2575\u4ee5\u53caMDM2-p53\u6291\u5236\u5242APG-115\u548cFAK\/ALK\/ROS1\u4e09\u8054\u6291\u5236\u5242APG-2449\u56db\u4e2a\u91cd\u70b9\u54c1\u79cd\u7684\u4e34\u5e8a\u7814\u7a76\u8fdb\u5c55\u3002\u503c\u5f97\u7279\u522b\u5173\u6ce8\u7684\u662f\uff0c\u8010\u7acb\u514b®<\/sup>\u57282023 ASCO\u5e74\u4f1a\u4e0a\u5c55\u73b0\u4e86\u8be5\u54c1\u79cd\u5728TKI\u8010\u836f\u7684\u7425\u73c0\u9178\u8131\u6c22\u9176\uff08SDH\uff09\u7f3a\u9677\u578b\u80c3\u80a0\u95f4\u8d28\u7624\uff08GIST\uff09\u60a3\u8005\u4e2d\u663e\u8457\u7684\u7597\u6548\u53ca\u826f\u597d\u7684\u5b89\u5168\u6027\uff0c\u6709\u671b\u4e3a\u8fd9\u4e00\u65e0\u836f\u53ef\u533b\u7684\u6cbb\u7597\u9886\u57df\u5e26\u6765\u91cd\u5927\u7a81\u7834\u3002\u6b64\u5916\uff0c\u8010\u7acb\u514b®<\/sup>\u8fd8\u5728\u62a5\u544a\u671f\u5185\u83b7CDE\u7eb3\u5165\u7a81\u7834\u6027\u6cbb\u7597\u54c1\u79cd\uff0c\u7528\u4e8e\u6cbb\u7597\u65e2\u5f80\u7ecf\u8fc7\u4e00\u7ebf\u6cbb\u7597\u7684SDH\u7f3a\u9677\u578bGIST\u60a3\u8005\uff0c\u5145\u5206\u4f53\u73b0\u5176\u5728\u8be5\u9886\u57df\u7684\u4e34\u5e8a\u4ef7\u503c\u3002<\/p>\n

\u6253\u9020\u4ea7\u4e1a\u94fe\u575a\u5b9e\u57fa\u7840\uff0c\u8d4b\u80fd\u4f01\u4e1a\u5168\u7403\u5316\u5e03\u5c40<\/strong><\/p>\n

\u4e9a\u76db\u533b\u836f\u59cb\u7ec8\u575a\u5b88”\u5168\u7403\u521b\u65b0”\u6218\u7565\uff0c\u5e76\u575a\u6301\u5168\u7403\u8303\u56f4\u5185\u7684\u77e5\u8bc6\u4ea7\u6743\u5e03\u5c40\u3002\u622a\u81f32023\u5e7412\u670831\u65e5\uff0c\u516c\u53f8\u5728\u5168\u7403\u62e5\u6709498\u9879\u6388\u6743\u4e13\u5229\uff0c\u5176\u4e2d352\u9879\u4e13\u5229\u4e3a\u6d77\u5916\u6388\u6743\u3002<\/p>\n

\u540c\u65f6\uff0c\u4e9a\u76db\u533b\u836f\u5728\u516c\u53f8\u5168\u7403\u751f\u4ea7\u5c42\u9762\u4e5f\u8fce\u6765\u91cc\u7a0b\u7891\u5f0f\u8fdb\u5c55\u3002\u516c\u53f8\u83b7\u5f97\u7531\u6b27\u76df\u8d28\u91cf\u53d7\u6743\u4eba\uff08Qualified Person, QP\uff09\u7b7e\u53d1\u7684\u836f\u54c1\u751f\u4ea7\u8d28\u91cf\u7ba1\u7406\u89c4\u8303\uff08GMP\uff09\u7b26\u5408\u6027\u5ba1\u8ba1\u62a5\u544a\uff0c\u5168\u7403\u4ea7\u4e1a\u57fa\u5730\u96f6\u7f3a\u9677\u901a\u8fc7\u6b27\u76dfQP\u5ba1\u8ba1\u3002\u8fd9\u6807\u5fd7\u7740\u4e9a\u76db\u533b\u836f\u5168\u7403\u4ea7\u4e1a\u57fa\u5730\u53ca\u5176\u8d28\u91cf\u7ba1\u7406\u4f53\u7cfb\u5df2\u7b26\u5408\u6b27\u76dfGMP\u6807\u51c6\uff0c\u5c06\u8fdb\u4e00\u6b65\u52a9\u529b\u516c\u53f8\u8fc8\u5411\u5168\u7403\u521b\u65b0\u751f\u7269\u5236\u836f\u4f01\u4e1a\u3002<\/p>\n

\u4e9a\u76db\u533b\u836f\u8463\u4e8b\u957f\u3001CEO\u6768\u5927\u4fca\u535a\u58eb\u8868\u793a\uff1a”\u56de\u987e2023\u5e74\uff0c\u4e9a\u76db\u533b\u836f\u5728\u4ea7\u54c1\u5546\u4e1a\u5316\u3001\u5168\u7403\u4e34\u5e8a\u5f00\u53d1\u53ca\u4f01\u4e1a\u53d1\u5c55\u65b9\u9762\u5747\u53d6\u5f97\u4e86\u8bf8\u591a\u91cc\u7a0b\u7891\u5f0f\u8fdb\u5c55\uff0c\u5c55\u73b0\u4e86\u516c\u53f8\u5728\u5168\u7403\u521b\u65b0\u7814\u53d1\u9886\u57df\u7684\u80fd\u529b\u3002<\/p>\n

\u968f\u7740\u8010\u7acb\u514b®<\/sup>\u88ab\u7eb3\u5165\u56fd\u5bb6\u533b\u4fdd\u76ee\u5f55\u5e76\u83b7\u65b0\u9002\u5e94\u75c7\u4e0a\u5e02\u6279\u51c6\uff0c\u516c\u53f8\u5546\u4e1a\u5316\u80fd\u529b\u83b7\u5f97\u8fdb\u4e00\u6b65\u63d0\u5347\u3002\u540c\u65f6\uff0c\u51ed\u501f\u7740\u4f18\u79c0\u7684\u7597\u6548\u548c\u5b89\u5168\u6027\u6570\u636e\uff0c\u8010\u7acb\u514b®<\/sup>\u518d\u6b21\u592f\u5b9e\u4e86‘Best-in-class’\u7684\u5730\u4f4d\uff0c\u5e76\u5728\u66f4\u591a\u65e0\u836f\u53ef\u533b\u7684\u9886\u57df\u5c55\u73b0\u51fa\u6781\u5927\u7684\u4e34\u5e8a\u4ef7\u503c\u3002<\/p>\n

\u8fc7\u53bb\u4e00\u5e74\uff0c\u6211\u4eec\u52a0\u901f\u63a8\u8fdb\u516c\u53f8\u4e34\u5e8a\u5f00\u53d1\u5168\u7403\u5316\u5e03\u5c40\uff0c\u4e24\u5927\u6838\u5fc3\u54c1\u79cd\u8010\u7acb\u514b®<\/sup>\u548cBcl-2\u6291\u5236\u5242APG-2575\u5171\u65a9\u83b7\u4e865\u9879\u5168\u7403\u6ce8\u518cIII\u671f\u4e34\u5e8a\u6279\u51c6\uff0c\u5176\u4e2d2\u9879\u4e3a\u7f8e\u56fdFDA\u8bb8\u53ef\uff0c\u5145\u5206\u5f70\u663e\u4e86\u516c\u53f8\u5728\u8840\u6db2\u80bf\u7624\u9886\u57df\u7684\u9886\u5148\u6c34\u5e73\u3002\u540c\u65f6\uff0c\u516c\u53f8\u7ba1\u7ebf\u91cd\u70b9\u54c1\u79cd\u7684\u9002\u5e94\u75c7\u83b7\u5f97\u4e0d\u65ad\u62d3\u5c55\uff0c\u8fdb\u4e00\u6b65\u6784\u7b51\u516c\u53f8\u8840\u6db2\u80bf\u7624\u9886\u57df\u7684\u5f3a\u52b2\u62a4\u57ce\u6cb3\u3002<\/p>\n

\u4e9a\u76db\u533b\u836f\u4ee5\u60a3\u8005\u4e3a\u4e2d\u5fc3\u3001\u4ee5‘\u5168\u7403\u521b\u65b0’\u4e3a\u7406\u5ff5\uff0c\u6784\u5efa\u4e86\u4e00\u6761\u4e34\u5e8a\u4ef7\u503c\u4e30\u5bcc\u7684\u7814\u53d1\u7ba1\u7ebf\uff0c\u5728\u8840\u6db2\u80bf\u7624\u9886\u57df\u7684\u6f5c\u529b\u5c24\u4e3a\u663e\u8457\u3002\u672a\u6765\uff0c\u6211\u4eec\u5c06\u4e0d\u65ad\u5f3a\u5316\u516c\u53f8\u7684\u5546\u4e1a\u5316\u53ca\u521b\u65b0\u7814\u53d1\u80fd\u529b\uff0c\u52a0\u901f\u5728\u7814\u54c1\u79cd\u5728\u5168\u7403\u8303\u56f4\u5185\u7684\u4e34\u5e8a\u5f00\u53d1\u3002\u6211\u4eec\u671f\u5f85\u672a\u6765\u80fd\u5c06\u5168\u7403\u521b\u65b0\u836f\u7269\u63a8\u5165\u56fd\u9645\u5e02\u573a\uff0c\u771f\u6b63\u8df5\u884c‘\u89e3\u51b3\u4e2d\u56fd\u4e43\u81f3\u5168\u7403\u60a3\u8005\u5c1a\u672a\u6ee1\u8db3\u7684\u4e34\u5e8a\u9700\u6c42’\u7684\u4f7f\u547d\uff0c\u60e0\u53ca\u5168\u7403\u60a3\u8005\uff0c\u4e3a\u793e\u4f1a\u548c\u80a1\u4e1c\u521b\u9020\u66f4\u591a\u4ef7\u503c\u3002”<\/p>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

\u4e2d\u56fd\u82cf\u5dde\u548c\u7f8e\u56fd\u9a6c\u91cc\u5170\u5dde\u7f57\u514b\u7ef4\u5c14\u5e022024\u5e743\u670827\u65e5 \/\u7f8e\u901a\u793e\/ — \u4e9a\u76db\u533b\u836f\uff086855.HK\uff09\u4eca\u65e5\u516c\u5e032023\u5e74\u5168\u5e74\u4e1a\u7ee9\u3002\u62a5\u544a\u671f\u5185\uff0c\u516c\u53f8\u5728\u5546\u4e1a\u5316\u81ea\u6211\u9020\u8840\u80fd\u529b\u6301\u7eed\u63d0\u5347\u7684\u540c\u65f6\uff0c\u5feb\u901f\u63a8\u8fdb\u4ee5\u60a3\u8005\u4e3a\u4e2d\u5fc3\u7684”\u5168\u7403\u521b\u65b0”\u6218\u7565\uff0c\u5728\u4e34\u5e8a\u5f00\u53d1\u53ca\u56fd\u9645\u5316\u5e03\u5c40\u7b49\u65b9\u9762\u5747\u83b7\u5f97\u91cc\u7a0b\u7891\u5f0f\u8fdb\u5c55\u3002 \u8010\u7acb\u514b®\u65b0\u9002\u5e94\u75c7\u83b7\u6279\uff0c\u8fce\u6765\u66f4\u5e7f\u9614\u5e02\u573a 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\u65a9\u83b75\u9879\u5168\u7403\u6ce8\u518cIII\u671f\u4e34\u5e8a\uff0c\u5168\u7403\u521b\u65b0\u6b65\u5165\u6536\u83b7\u671f \u5728”\u5168\u7403\u521b\u65b0”\u7684\u6218\u7565\u5f15\u5bfc\u4e0b\uff0c\u4e9a\u76db\u533b\u836f2023\u5e74\u5728\u4e34\u5e8a\u5f00\u53d1\u65b9\u9762\u53d6\u5f97\u4e86\u591a\u9879\u91cc\u7a0b\u7891\u8fdb\u5c55\uff0c\u5168\u7403\u4e34\u5e8a\u5e03\u5c40\u6b63\u5728\u9ad8\u6548\u63a8\u8fdb\u4e2d\u3002\u622a\u81f3\u4eca\u65e5\uff0c\u516c\u53f8\u4e24\u5927\u6838\u5fc3\u54c1\u79cd\uff0c\u8010\u7acb\u514b®\u53caBcl-2\u6291\u5236\u5242APG-2575\u5171\u6536\u83b75\u9879\u5168\u7403\u6ce8\u518cIII\u671f\u4e34\u5e8a\u8bd5\u9a8c\u6279\u51c6\uff0c\u5728\u8840\u6db2\u80bf\u7624\u9886\u57df\u5efa\u7acb\u8d77\u6df1\u539a\u7684\u62a4\u57ce\u6cb3\u3002 2024\u5e742\u6708\uff0c\u8010\u7acb\u514b®\u83b7\u7f8e\u56fd\u98df\u54c1\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08FDA\uff09\u6279\u51c6\u5f00\u5c55\u4e00\u9879\u5168\u7403\u6ce8\u518cIII\u671f\u4e34\u5e8a\u7814\u7a76\uff0c\u7528\u4e8e\u6cbb\u7597\u65e2\u5f80\u63a5\u53d7\u8fc7\u6cbb\u7597\u7684CML-CP\u6210\u5e74\u60a3\u8005\u3002\u8fd9\u662f\u8010\u7acb\u514b®\u83b7\u7f8e\u56fdFDA\u6279\u51c6\u7684\u9996\u4e2a\u6ce8\u518cIII\u671f\u4e34\u5e8a\u7814\u7a76\uff0c\u4e5f\u662f\u4e9a\u76db\u533b\u836f\u5168\u7403\u8840\u6db2\u80bf\u7624\u5e03\u5c40\u7684\u91cd\u8981\u4e00\u6b65\u3002\u503c\u5f97\u4e00\u63d0\u7684\u662f\uff0c\u8010\u7acb\u514b®\u4f5c\u4e3a\u5177\u6709\u5168\u7403\u5c42\u9762”Best-in-class”\u5b9e\u529b\u7684\u4e2d\u56fd\u539f\u521b\u65b0\u836f\uff0c\u57282024\u5e741\u6708\u83b7\u7eb3\u5165\u6700\u65b0\u7248\u7f8e\u56fd\u56fd\u5bb6\u7efc\u5408\u764c\u75c7\u7f51\u7edc\uff08NCCN\uff09CML\u6cbb\u7597\u6307\u5357\uff0c\u6807\u5fd7\u7740\u8be5\u4ea7\u54c1\u5177\u6709\u663e\u8457\u7684\u4e34\u5e8a\u4ef7\u503c\u53ca\u56fd\u9645\u80bf\u7624\u5b66\u754c\u7684\u9ad8\u5ea6\u8ba4\u53ef\u3002 \u5728CML\u9886\u57df\u4e4b\u5916\uff0c\u8010\u7acb\u514b®\u9488\u5bf9\u8d39\u57ce\u67d3\u8272\u4f53\u9633\u6027\uff08Ph+\uff09\u6025\u6027\u6dcb\u5df4\u7ec6\u80de\u767d\u8840\u75c5\uff08ALL\uff09\u7684\u4e34\u5e8a\u5f00\u53d1\u4e5f\u83b7\u5f97\u91cd\u5927\u8fdb\u5c55\uff0c\u4e8e2023\u5e747\u6708\u83b7\u5f97\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08NMPA\uff09\u836f\u7269\u5ba1\u8bc4\u4e2d\u5fc3\uff08CDE\uff09\u4e34\u5e8a\u8bd5\u9a8c\u8bb8\u53ef\uff0c\u5f00\u5c55\u8054\u5408\u5316\u7597\u5bf9\u6bd4\u4f0a\u9a6c\u66ff\u5c3c\u8054\u5408\u5316\u7597\u6cbb\u7597\u65b0\u8bca\u65ad\u7684Ph+ ALL\u60a3\u8005\u7684\u5168\u7403\u6ce8\u518cIII\u671f\u4e34\u5e8a\u3002\u8fd9\u610f\u5473\u7740\u8010\u7acb\u514b®\u6709\u671b\u6210\u4e3a\u56fd\u5185\u9996\u4e2a\u83b7\u6279\u7528\u4e8e\u4e00\u7ebf\u6cbb\u7597Ph+ ALL\u7684TKI\u836f\u7269\u3002 \u6b64\u5916\uff0c\u4e9a\u76db\u533b\u836f\u4e5f\u5728\u540c\u6b65\u6df1\u8015APG-2575\u5728\u8840\u6db2\u80bf\u7624\u9886\u57df\u7684\u4e34\u5e8a\u5e03\u5c40\uff0c\u5728\u62a5\u544a\u671f\u5185\u65a9\u83b7\u4e863\u9879\u5168\u7403\u6ce8\u518cIII\u671f\u4e34\u5e8a\u7814\u7a76\u30022023\u5e748\u6708\uff0cAPG-2575\u83b7\u7f8e\u56fdFDA\u6279\u51c6\u5f00\u5c55\u4e00\u9879\u5168\u7403\u6ce8\u518cIII\u671f\u4e34\u5e8a\u7814\u7a76\uff0c\u7528\u4e8e\u6cbb\u7597\u65e2\u5f80\u63a5\u53d7\u6cbb\u7597\u7684\u6162\u6027\u6dcb\u5df4\u7ec6\u80de\u767d\u8840\u75c5\uff08CLL\uff09\/\u5c0f\u6dcb\u5df4\u7ec6\u80de\u6dcb\u5df4\u7624\uff08SLL\uff09\u60a3\u8005\uff0c\u662fAPG-2575\u56fd\u9645\u5316\u8fdb\u7a0b\u7684\u4e00\u9879\u91cd\u5927\u91cc\u7a0b\u7891\u3002\u8fd9\u610f\u5473\u7740APG-2575\u6709\u671b\u52a0\u901f\u6210\u4e3a\u5168\u7403\u7b2c\u4e8c\u4e2a\u83b7\u6279\u4e0a\u5e02\u7684Bcl-2\u6291\u5236\u5242\uff0c\u5e76\u771f\u6b63\u8dfb\u8eab\u56fd\u9645\u7ade\u4e89\u9635\u8425\u3002\u968f\u540e\uff0cAPG-2575\u83b7CDE\u4e34\u5e8a\u8bd5\u9a8c\u8bb8\u53ef\uff0c\u5f00\u5c55\u5176\u8054\u5408\u5e03\u9c81\u987f\u916a\u6c28\u9178\u6fc0\u9176\uff08BTK\uff09\u6291\u5236\u5242\u963f\u53ef\u66ff\u5c3c\u5bf9\u6bd4\u514d\u75ab\u5316\u7597\u7684\u5168\u7403\u6ce8\u518cIII\u671f\u4e34\u5e8a\u7814\u7a76, \u7528\u4e8e\u4e00\u7ebf\u6cbb\u7597\u521d\u6cbbCLL\/SLL\u60a3\u8005\u3002\u540c\u5e7412\u6708\uff0cAPG-2575\u518d\u83b7\u4e00\u9879CDE\u6279\u51c6\u7684\u5168\u7403\u6ce8\u518cIII\u671f\u4e34\u5e8a\u7814\u7a76\uff0c\u7528\u4e8e\u4e00\u7ebf\u6cbb\u7597\u65b0\u8bca\u65ad\u8001\u5e74\u6216\u4f53\u5f31\u6025\u6027\u9ad3\u7cfb\u767d\u8840\u75c5\uff08AML\uff09\u60a3\u8005\u3002 \u4e34\u5e8a\u6570\u636e\u5f3a\u52b2\uff0c\u5f70\u663e\u8840\u6db2\u80bf\u7624\u9886\u57df\u7ade\u4e89\u5b9e\u529b \u79c9\u627f”\u89e3\u51b3\u4e2d\u56fd\u4e43\u81f3\u5168\u7403\u60a3\u8005\u5c1a\u672a\u6ee1\u8db3\u7684\u4e34\u5e8a\u9700\u6c42”\u7684\u4f7f\u547d\uff0c\u4e9a\u76db\u533b\u836f\u6253\u9020\u4e86\u4e00\u6761\u5177\u6709”First-in-class”\u4e0e”Best-in-class”\u6f5c\u529b\u7684\u4e30\u5bcc\u7684\u4ea7\u54c1\u7ba1\u7ebf\uff0c\u6b63\u5728\u4e2d\u56fd\u3001\u7f8e\u56fd\u3001\u6fb3\u5927\u5229\u4e9a\u3001\u6b27\u6d32\u53ca\u52a0\u62ff\u5927\u5f00\u5c5540\u591a\u9879\u4e34\u5e8a\u8bd5\u9a8c\u3002\u591a\u4e2a\u7ba1\u7ebf\u54c1\u79cd\u7684\u6cbb\u7597\u6f5c\u529b\u88ab\u4e0d\u65ad\u6316\u6398\u9a8c\u8bc1\uff0c\u5728\u5404\u5927\u56fd\u9645\u5b66\u672f\u4f1a\u8bae\u6301\u7eed\u62ab\u9732\u4e34\u5e8a\u6570\u636e\uff0c\u5145\u5206\u4f53\u73b0\u4e86\u56fd\u9645\u5b66\u672f\u754c\u5bf9\u516c\u53f8\u521b\u65b0\u4e0e\u4e34\u5e8a\u5f00\u53d1\u80fd\u529b\u7684\u9ad8\u5ea6\u8ba4\u53ef\u3002 \u7b2c65\u5c4a\u7f8e\u56fd\u8840\u6db2\u5b66\u4f1a\uff082023 ASH\uff09\u5e74\u4f1a\u4e0a\uff0c\u4e9a\u76db\u533b\u836f\u4e24\u5927\u6838\u5fc3\u54c1\u79cd\u8010\u7acb\u514b®\u53caAPG-2575\u7684\u591a\u9879\u6700\u65b0\u7814\u7a76\u8fdb\u5c55\u5165\u9009\u5c55\u793a\uff0c\u5f70\u663e\u7740\u516c\u53f8\u5728\u8840\u6db2\u80bf\u7624\u9886\u57df\u4e0d\u65ad\u63d0\u5347\u7684\u7ade\u4e89\u58c1\u5792\u3002 \u5176\u4e2d\uff0c\u8010\u7acb\u514b®\u4e24\u9879\u7814\u7a76\u5165\u9009\u53e3\u5934\u62a5\u544a\uff0c\u8fd9\u662f\u8be5\u54c1\u79cd\u8fde\u7eed\u7b2c\u516d\u5e74\u83b7ASH\u5e74\u4f1a\u53e3\u5934\u62a5\u544a\u3002\u53e3\u5934\u62a5\u544a\u4e4b\u4e00\u7684\u662f\u4e00\u9879\u65e8\u5728\u8bc4\u4f30\u8010\u7acb\u514b®\u5bf9\u6bd4\u73b0\u6709\u6700\u4f73\u53ef\u7528\u7597\u6cd5\uff08BAT\uff09\u5728\u65e2\u5f80TKIs\u8010\u836f\u548c\/\u6216\u4e0d\u8010\u53d7\u7684CML-CP\u60a3\u8005\u4e2d\u7684\u7597\u6548\u4e0e\u5b89\u5168\u6027\u7684\u6ce8\u518cII\u671f\u7814\u7a76\u3002\u6570\u636e\u663e\u793a\uff0c\u8010\u7acb\u514b®\u5bf9\u6bd4BAT\u5bf9\u7167\u7ec4\uff0c\u663e\u8457\u6539\u5584\u4e86CML\u60a3\u8005\u7684\u4e34\u5e8a\u9884\u540e\uff1b\u53e6\u4e00\u9879\u53e3\u5934\u62a5\u544a\u4e3a\u6cbb\u7597\u521d\u6cbbPh+ ALL\u60a3\u8005\u7684II\u671f\u4e34\u5e8a\u8bd5\u9a8c\u65e9\u671f\u7ed3\u679c\uff0c\u8363\u767b”Highlights of ASH”\uff0c\u6570\u636e\u5448\u73b0\u51fa\u5353\u8d8a\u7597\u6548\u548c\u5b89\u5168\u6027\uff0c\u6709\u671b\u63a8\u52a8Ph+ ALL\u6cbb\u7597\u8fdb\u5165”\u65e0\u5316\u7597”\u65f6\u4ee3\u3002 \u800c\u7ee72022\u5e74\u5728ASH\u5e74\u4f1a\u4e0a\u53e3\u5934\u62a5\u544a\u8010\u7acb\u514b®\u6d77\u5916\u7814\u7a76\u7684\u521d\u6b65\u6570\u636e\u540e\uff0c\u901a\u8fc7\u66f4\u5927\u6837\u672c\u91cf\u60a3\u8005\u7684\u6570\u636e\uff0c\u4e9a\u76db\u533b\u836f\u57282023 ASH\u5e74\u4f1a\u4e0a\u8fdb\u4e00\u6b65\u9a8c\u8bc1\u4e86\u8be5\u54c1\u79cd\u5355\u836f\u6216\u8054\u5408\u6cbb\u7597\u5728\u524d\u671f\u7ecf\u6df1\u5ea6\u6cbb\u7597\u7684CML\u6216Ph+ ALL\u60a3\u8005\u4e2d\u7597\u6548\u4e0e\u8010\u53d7\u6027\u4ff1\u4f73\uff0c\u5c24\u5176\u662f\u5728\u7ecf\u7b2c\u4e09\u4ee3TKI ponatinib\u6216\u53d8\u6784\u6291\u5236\u5242asciminib\u6cbb\u7597\u5931\u8d25\u7684\u60a3\u8005\u4e2d\u7597\u6548\u663e\u8457\uff0c\u518d\u6b21\u9a8c\u8bc1\u4e86\u8010\u7acb\u514b®\u4e3a\u5168\u7403\u5c42\u9762”Best-in-class”\u836f\u7269\uff0c\u6709\u671b\u4e3a\u5168\u7403CML\u6216Ph+ ALL\u60a3\u8005\u63d0\u4f9b\u65b0\u7684\u6709\u6548\u6cbb\u7597\u65b9\u6848\u3002 \u57282023 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\u4e9a\u76db\u533b\u836f\u59cb\u7ec8\u575a\u5b88”\u5168\u7403\u521b\u65b0”\u6218\u7565\uff0c\u5e76\u575a\u6301\u5168\u7403\u8303\u56f4\u5185\u7684\u77e5\u8bc6\u4ea7\u6743\u5e03\u5c40\u3002\u622a\u81f32023\u5e7412\u670831\u65e5\uff0c\u516c\u53f8\u5728\u5168\u7403\u62e5\u6709498\u9879\u6388\u6743\u4e13\u5229\uff0c\u5176\u4e2d352\u9879\u4e13\u5229\u4e3a\u6d77\u5916\u6388\u6743\u3002 \u540c\u65f6\uff0c\u4e9a\u76db\u533b\u836f\u5728\u516c\u53f8\u5168\u7403\u751f\u4ea7\u5c42\u9762\u4e5f\u8fce\u6765\u91cc\u7a0b\u7891\u5f0f\u8fdb\u5c55\u3002\u516c\u53f8\u83b7\u5f97\u7531\u6b27\u76df\u8d28\u91cf\u53d7\u6743\u4eba\uff08Qualified Person, QP\uff09\u7b7e\u53d1\u7684\u836f\u54c1\u751f\u4ea7\u8d28\u91cf\u7ba1\u7406\u89c4\u8303\uff08GMP\uff09\u7b26\u5408\u6027\u5ba1\u8ba1\u62a5\u544a\uff0c\u5168\u7403\u4ea7\u4e1a\u57fa\u5730\u96f6\u7f3a\u9677\u901a\u8fc7\u6b27\u76dfQP\u5ba1\u8ba1\u3002\u8fd9\u6807\u5fd7\u7740\u4e9a\u76db\u533b\u836f\u5168\u7403\u4ea7\u4e1a\u57fa\u5730\u53ca\u5176\u8d28\u91cf\u7ba1\u7406\u4f53\u7cfb\u5df2\u7b26\u5408\u6b27\u76dfGMP\u6807\u51c6\uff0c\u5c06\u8fdb\u4e00\u6b65\u52a9\u529b\u516c\u53f8\u8fc8\u5411\u5168\u7403\u521b\u65b0\u751f\u7269\u5236\u836f\u4f01\u4e1a\u3002 \u4e9a\u76db\u533b\u836f\u8463\u4e8b\u957f\u3001CEO\u6768\u5927\u4fca\u535a\u58eb\u8868\u793a\uff1a”\u56de\u987e2023\u5e74\uff0c\u4e9a\u76db\u533b\u836f\u5728\u4ea7\u54c1\u5546\u4e1a\u5316\u3001\u5168\u7403\u4e34\u5e8a\u5f00\u53d1\u53ca\u4f01\u4e1a\u53d1\u5c55\u65b9\u9762\u5747\u53d6\u5f97\u4e86\u8bf8\u591a\u91cc\u7a0b\u7891\u5f0f\u8fdb\u5c55\uff0c\u5c55\u73b0\u4e86\u516c\u53f8\u5728\u5168\u7403\u521b\u65b0\u7814\u53d1\u9886\u57df\u7684\u80fd\u529b\u3002 \u968f\u7740\u8010\u7acb\u514b®\u88ab\u7eb3\u5165\u56fd\u5bb6\u533b\u4fdd\u76ee\u5f55\u5e76\u83b7\u65b0\u9002\u5e94\u75c7\u4e0a\u5e02\u6279\u51c6\uff0c\u516c\u53f8\u5546\u4e1a\u5316\u80fd\u529b\u83b7\u5f97\u8fdb\u4e00\u6b65\u63d0\u5347\u3002\u540c\u65f6\uff0c\u51ed\u501f\u7740\u4f18\u79c0\u7684\u7597\u6548\u548c\u5b89\u5168\u6027\u6570\u636e\uff0c\u8010\u7acb\u514b®\u518d\u6b21\u592f\u5b9e\u4e86‘Best-in-class’\u7684\u5730\u4f4d\uff0c\u5e76\u5728\u66f4\u591a\u65e0\u836f\u53ef\u533b\u7684\u9886\u57df\u5c55\u73b0\u51fa\u6781\u5927\u7684\u4e34\u5e8a\u4ef7\u503c\u3002 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More<\/a><\/p>\n","protected":false},"author":556,"featured_media":109410,"comment_status":"close","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1965],"tags":[],"class_list":["post-109407","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-partnerships"],"amp_enabled":true,"_links":{"self":[{"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/posts\/109407","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/users\/556"}],"replies":[{"embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/comments?post=109407"}],"version-history":[{"count":1,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/posts\/109407\/revisions"}],"predecessor-version":[{"id":109409,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/posts\/109407\/revisions\/109409"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/media\/109410"}],"wp:attachment":[{"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/media?parent=109407"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/categories?post=109407"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/tags?post=109407"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}