{"id":108844,"date":"2024-03-22T18:00:00","date_gmt":"2024-03-22T11:00:00","guid":{"rendered":"https:\/\/www.xinwengao.com\/cn\/pr\/20240322180000108844"},"modified":"2024-03-23T00:35:04","modified_gmt":"2024-03-22T16:35:04","slug":"%e8%85%be%e7%9b%9b%e5%8d%9a%e8%8d%af%e5%8f%91%e5%b8%832023%e5%b9%b4%e5%ba%a6%e5%85%a8%e5%b9%b4%e8%b4%a2%e5%8a%a1%e4%b8%9a%e7%bb%a9%e5%8f%8a%e5%85%ac%e5%8f%b8%e6%9c%80%e6%96%b0%e8%bf%9b%e5%b1%95","status":"publish","type":"post","link":"https:\/\/www.xinwengao.com\/cn\/pr\/20240322180000108844","title":{"rendered":"\u817e\u76db\u535a\u836f\u53d1\u5e032023\u5e74\u5ea6\u5168\u5e74\u8d22\u52a1\u4e1a\u7ee9\u53ca\u516c\u53f8\u6700\u65b0\u8fdb\u5c55"},"content":{"rendered":"<table border=\"0\" cellspacing=\"10\" cellpadding=\"5\" align=\"right\">\n<tbody>\n<tr>\n<td><img decoding=\"async\" src=\"https:\/\/www.xinwengao.com\/cn\/wp-content\/uploads\/Logo-615.jpg\" border=\"0\" alt=\"\" title=\"logo\" hspace=\"0\" vspace=\"0\" width=\"118\" \/><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p class=\"prntac\"><i>\u5c06\u4e59\u809d\u6cbb\u6108\u9879\u76ee\u63a8\u8fdb\u81f3\u591a\u9879\u540e\u671f\u4e34\u5e8a\u8054\u5408\u7814\u7a76\uff0c<\/i><i>2024<\/i><i>\u5e74\u548c<\/i><i>&nbsp;2025<\/i><i>\u5e74\u53d6\u5f97\u7684\u4e2d\u671f\u7ed3\u679c\u5c06\u4e3a\u516c\u53f8\u7684\u6ce8\u518c\u6218\u7565\u63d0\u4f9b\u4f9d\u636e<\/i><\/p>\n<p class=\"prntac\"><i>\u901a\u8fc7\u6536\u8d2d<\/i><i>BRII-179<\/i><i>\u7684\u5168\u7403\u77e5\u8bc6\u4ea7\u6743\u5e76\u62d3\u5c55\u751f\u4ea7\u5e03\u5c40\uff0c\u4ee5\u6574\u5408\u7814\u53d1\u3001\u751f\u4ea7\u548c\u5546\u4e1a\u4f18\u52bf<\/i><\/p>\n<p class=\"prntac\"><i>\u4f18\u5316\u516c\u53f8\u8d44\u6e90\uff0c<\/i><i>3.76<\/i><i>\u4ebf\u7f8e\u5143\u7684\u5145\u8db3\u73b0\u91d1\u5c06\u652f\u6301\u516c\u53f8\u8fd0\u8425\u81f3<\/i><i>&nbsp;2027<\/i><i>\u5e74<\/i><\/p>\n<p class=\"prntac\"><i>\u516c\u53f8\u5c06\u4e8e<\/i><i>3 <\/i><i>\u6708<\/i><i>&nbsp;25<\/i><i>\u65e5\u4e0a\u5348<\/i><i>8:30<\/i><i>\uff08\u9999\u6e2f\u65f6\u95f4\uff09<\/i><i>\/ 3<\/i><i>\u6708<\/i><i>24<\/i><i>\u65e5\u665a\u95f4<\/i><i>8:30<\/i><i>\uff08\u7f8e\u4e1c\u65f6\u95f4\uff09\u53ec\u5f00\u7535\u8bdd\u4f1a\u8bae\uff08\u4e2d\u6587\u573a\uff09<\/i><\/p>\n<p><p><span class=\"legendSpanClass\">\u4e2d\u56fd\u5317\u4eac\u548c\u7f8e\u56fd\u5317\u5361\u7f57\u83b1\u7eb3\u5dde\u8fbe\u52d2\u59c6\u5e02<\/span><span class=\"legendSpanClass\">2024\u5e743\u670822\u65e5<\/span> \/\u7f8e\u901a\u793e\/ &#8212; <a href=\"https:\/\/www.briibio.com\/cn\/\" target=\"_blank\" rel=\"nofollow noopener\">\u817e\u76db\u535a\u836f\u751f\u7269\u79d1\u6280\u6709\u9650\u516c\u53f8<\/a>\uff08&quot;\u817e\u76db\u535a\u836f&quot;\u6216&quot;\u516c\u53f8&quot;\uff0c\u80a1\u7968\u4ee3\u7801\uff1a2137.HK\uff09\uff0c\u4e00\u5bb6\u81f4\u529b\u4e8e\u9488\u5bf9\u60a3\u8005\u672a\u88ab\u6ee1\u8db3\u7684\u9700\u6c42\u4ee5\u53ca\u91cd\u5927\u516c\u5171\u536b\u751f\u6027\u75be\u75c5\u5f00\u53d1\u521b\u65b0\u7597\u6cd5\u7684\u8de8\u56fd\u4f01\u4e1a\uff0c\u4eca\u65e5\u53d1\u5e03\u4e86\u6700\u65b0\u516c\u53f8\u8fdb\u5c55\u548c\u622a\u81f32023\u5e7412\u670831\u65e5\u7684\u5168\u5e74\u4e1a\u7ee9\u62a5\u544a\u3002<\/p>\n<p>2023\u5e74\uff0c\u516c\u53f8\u5728\u5176\u91cd\u70b9\u7684\u4e59\u578b\u809d\u708e\u75c5\u6bd2\uff08HBV\uff09\u9879\u76ee\u4e2d\u53d6\u5f97\u4e86\u91cd\u8981\u91cc\u7a0b\u7891\uff0c\u63a8\u52a8\u4e86HBV\u529f\u80fd\u6027\u6cbb\u6108\u65b0\u578b\u8054\u5408\u7597\u6cd5\u7684\u5f00\u53d1\uff0c\u540c\u65f6\u62d3\u5c55\u4e86\u4ea7\u54c1\u7ec4\u5408\u3002\u968f\u7740\u6b63\u5728\u8fdb\u884c\u7684\u591a\u4e2aHBV\u5019\u9009\u836f\u7269\u4e34\u5e8a\u8bd5\u9a8c\u4ea7\u751f\u5f62\u6210\u6027\u6570\u636e\uff0c\u4ee5\u53ca\u83b7\u5f97\u4e86BRII-179\u7684\u5168\u7403\u77e5\u8bc6\u4ea7\u6743\u548c\u751f\u4ea7\u6280\u672f\uff0c\u516c\u53f8\u5c06\u57282024\u5e74\u542f\u52a8\u591a\u9879\u8054\u5408\u7597\u6cd5\u7684\u7814\u7a76\u3002<\/p>\n<p>\u817e\u76db\u535a\u836f\u8463\u4e8b\u957f\u517c\u9996\u5e2d\u6267\u884c\u5b98\u6d2a\u5fd7\u535a\u58eb\u8868\u793a\uff1a&quot;2023\u5e74\u5bf9\u817e\u76db\u535a\u836f\u6765\u8bf4\u662f\u5173\u952e\u7684\u4e00\u5e74\uff0c\u6211\u4eec\u4ece\u591a\u98792\u671f\u8054\u5408\u7814\u7a76\u4e2d\u83b7\u5f97\u4e86\u91cd\u8981\u6d1e\u89c1\u3002\u901a\u8fc7\u8fc7\u53bb5\u5e74\u7684\u79ef\u6781\u4e34\u5e8a\u7814\u7a76\uff0c\u6211\u4eec\u6df1\u5165\u4e86\u89e3\u4e86\u6700\u5927\u9650\u5ea6\u51cf\u5c11\u548c\u7ef4\u6301\u4e59\u809d\u8868\u9762\u6297\u539f\uff08HBsAg\uff09\u6e05\u9664\u6240\u9700\u7684\u6761\u4ef6\u3002\u57fa\u4e8eBRII-179\uff0c\u6211\u4eec\u5236\u5b9a\u4e86\u8bc4\u4f30\u548c\u589e\u5f3a\u4e59\u809d\u60a3\u8005\u5185\u5728\u514d\u75ab\u529b\u7684\u7b56\u7565\uff0c\u9488\u5bf9\u6700\u6709\u53ef\u80fd\u4ea7\u751f\u5e94\u7b54\u7684\u60a3\u8005\u8fdb\u884c\u6cbb\u7597\uff0c\u540c\u65f6\u907f\u514d\u5176\u4ed6\u60a3\u8005\u63a5\u53d7\u4e0d\u5fc5\u8981\u7684\u6cbb\u7597\u3002\u8fd9\u4e9b\u91cd\u8981\u7a81\u7834\u4e3a\u6211\u4eec\u7684\u540e\u671f\u4e34\u5e8a\u8054\u5408\u7814\u7a76\u63d0\u4f9b\u4e86\u4f9d\u636e\u3002&quot;<\/p>\n<p><b><u>2023<\/u><\/b><b><u>\u8d22\u5e74\u53ca\u8fd1\u671f\u516c\u53f8\u8fdb\u5c55<\/u><\/b><\/p>\n<ul type=\"disc\">\n<li>2024\u5e742\u6708\uff0c\u817e\u76db\u535a\u836f\u4e0eVBI Vaccines, Inc.\uff08&quot;VBI&quot;\uff0c\u7eb3\u65af\u8fbe\u514b\u80a1\u7968\u4ee3\u7801\uff1aVBIV\uff09\u8fbe\u6210\u534f\u8bae\uff0c\u6536\u8d2d BRII-179\u7684\u5168\u7403\u77e5\u8bc6\u4ea7\u6743\u548c\u751f\u4ea7\u6280\u672f\uff0c\u4ee5\u6269\u5927\u5176\u672a\u6765\u7684\u5168\u7403\u751f\u4ea7\u548c\u4f9b\u5e94\u80fd\u529b\u3002\u540c\u65f6\u8fd8\u53d6\u6d88\u4e86\u672a\u6765\u5411VBI\u652f\u4ed8\u7684\u4e0eBRII-179\u548cPreHevbri<sup>TM<\/sup>\u76f8\u5173\u7684\u8d39\u7528\u3002<\/li>\n<li>BRII-179\u4e8e2023\u5e7411\u6708\u83b7\u5f97\u4e2d\u56fd\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08NMPA\uff09\u836f\u54c1\u5ba1\u8bc4\u4e2d\u5fc3\uff08CDE\uff09\u9881\u53d1\u7684\u7a81\u7834\u6027\u7597\u6cd5\u8ba4\u5b9a\uff08BTD\uff09\uff0c\u52a0\u5feb\u4e3aHBV\u60a3\u8005\u63d0\u4f9b\u521b\u65b0\u7597\u6cd5\u3002<\/li>\n<li>\u817e\u76db\u535a\u836f\u4e8e2023\u5e747\u6708\u83b7\u5f97PreHevbri<sup>TM<\/sup>\u5728\u5927\u4e2d\u534e\u533a\u548c\u4e9a\u592a\u5730\u533a\uff08\u65e5\u672c\u9664\u5916\uff09\u7684\u72ec\u5bb6\u5f00\u53d1\u548c\u5546\u4e1a\u5316\u6743\u76ca\uff0c\u5e76\u5df2\u5c31PreHevbri<sup>TM<\/sup>\u5728\u4e2d\u56fd\u7684\u6ce8\u518c\u8ba1\u5212\u5411CDE<span id=\"spanHghlt3fa3\">\u63d0\u4ea4\u4e86\u4e24\u9879<\/span>\u4e34\u5e8a\u524d\u7533\u8bf7\uff08pre-IND\uff09\u3002\u9999\u6e2f\u7684\u4e0a\u5e02\u6ce8\u518c\u7533\u8bf7\u4e5f\u5df2\u63d0\u4ea4\u3002<\/li>\n<li>\u817e\u76db\u535a\u836f\u5df2\u4f18\u5316\u5176\u8d44\u6e90\uff0c\u91cd\u70b9\u6295\u5165\u5176\u9886\u5148\u7684HBV\u4ea7\u54c1\u7ec4\u5408\u7684\u4e34\u5e8a\u548c\u5546\u4e1a\u5f00\u53d1\u4e2d\u3002\u516c\u53f8\u6b63\u79ef\u6781\u5bfb\u6c42\u5408\u4f5c\u673a\u4f1a\uff0c\u4ee5\u8fdb\u4e00\u6b65\u5f00\u53d1\u5176\u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf\uff08CNS\uff09\u3001\u4eba\u7c7b\u514d\u75ab\u7f3a\u9677\u75c5\u6bd2\uff08HIV\uff09\u548c\u591a\u91cd\u8010\u836f\u548c\u5e7f\u6cdb\u8010\u836f\uff08MDR\/XDR\uff09\u9886\u57df\u62e5\u6709\u5168\u7403\u6743\u76ca\u7684\u7ba1\u7ebf\u3002<\/li>\n<li>\u817e\u76db\u535a\u836f\u4efb\u547dBrian A. Johns\u535a\u58eb\u4e3a\u9996\u5e2d\u79d1\u5b66\u5b98\uff0c\u8d1f\u8d23\u817e\u76db\u535a\u836f\u7684\u65e9\u671f\u53d1\u73b0\u9879\u76ee\uff0c\u5e76\u5236\u5b9a\u516c\u53f8\u672a\u6765\u7684\u7ba1\u7ebf\u6218\u7565\u3002\u6211\u4eec\u7684\u65b0\u7ec4\u7ec7\u6218\u7565\u7531\u5728\u611f\u67d3\u6027\u75be\u75c5\u9886\u57df\u62e5\u6709\u4e30\u5bcc\u7ecf\u9a8c\u7684\u9886\u5bfc\u8005\u6240\u5f15\u9886\uff0c\u4ee5\u786e\u4fdd\u516c\u53f8\u7ba1\u7ebf\u76ee\u6807\u7684\u8fbe\u6210\u3002<\/li>\n<\/ul>\n<p><b><u>2023<\/u><\/b><b><u>\u8d22\u5e74\u4e34\u5e8a\u7ba1\u7ebf\u4eae\u70b9\u548c\u672a\u6765\u91cc\u7a0b\u7891<\/u><\/b><\/p>\n<p><b><i><u>\u4e59\u578b\u809d\u708e\u75c5\u6bd2\uff08<\/u><\/i><\/b><b><i><u>HBV<\/u><\/i><\/b><b><i><u>\uff09\u9879\u76ee<\/u><\/i><\/b><\/p>\n<p>2023\u5e74\u83b7\u5f97\u7684\u5173\u952e\u6570\u636e\u8bc1\u660e\uff0c\u6211\u4eec\u62e5\u6709\u6240\u6709\u6743\u7684\u6cbb\u7597\u6027\u75ab\u82d7BRII-179\u53ef\u5728\u6162\u6027\u4e59\u578b\u809d\u708e\u60a3\u8005\u5f15\u53d1\u5f3a\u6548\u7684\u7279\u5f02\u6027\u514d\u75ab\u5e94\u7b54\uff0c\u5176\u4e0e\u4e34\u5e8a\u7597\u6548\u7684\u6539\u5584\u5bc6\u5207\u76f8\u5173\u3002\u817e\u76db\u535a\u836f\u4e0e\u5176\u6218\u7565\u5408\u4f5c\u4f19\u4f34\u5c06\u4e8e2024\u5e74\u5f00\u5c55\u4e00\u7cfb\u5217\u786e\u8bc1\u6027\u8054\u5408\u7814\u7a76\uff0c\u65e8\u5728\u5efa\u7acb\u4ee5BRII-179\u4e3a\u6838\u5fc3\u7684\u672a\u6765\u4e59\u809d\u6cbb\u7597\u65b9\u6848\u3002\u4e3a\u4e86\u8fdb\u4e00\u6b65\u5c65\u884c\u6211\u4eec\u5728BRII-179\u4e0a\u7684\u627f\u8bfa\uff0c\u817e\u76db\u535a\u836f\u4e0eVBI\u5c31\u5168\u7403\u77e5\u8bc6\u4ea7\u6743\u548c\u751f\u4ea7\u6743\u76ca\u8fbe\u6210\u4ea4\u6613\u3002\u6211\u4eec\u6b63\u4e0e\u5408\u4f5c\u4f19\u4f34\u5bc6\u5207\u5408\u4f5c\uff0c\u4ee5\u542f\u52a8\u540e\u671f\u4e34\u5e8a\u7814\u7a76\uff0c\u6765\u660e\u786eBRII-179\u548cBRII-835\uff08elebsiran\uff09\u5bf9\u63d0\u9ad8HBV\u529f\u80fd\u6027\u6cbb\u6108\u7387\u7684\u8d21\u732e\u3002\u6b64\u5916\uff0cBRII-179\u6709\u53ef\u80fd\u8bc6\u522b\u51fa\u80fd\u4ea7\u751f\u826f\u597d\u6297\u4f53\u5e94\u7b54\u5e76\u83b7\u5f97\u66f4\u9ad8\u529f\u80fd\u6027\u6cbb\u6108\u673a\u4f1a\u7684\u6162\u4e59\u809d\u60a3\u8005\u3002<\/p>\n<p><b>\u5173\u952e\u6570\u636e\u53ca\u5f00\u53d1\u8ba1\u5212<\/b><\/p>\n<ul type=\"disc\">\n<li><b>BRII-179 \u76f8\u5173\u7814\u7a76\u548c\u8ba1\u5212<\/b>\n<ul type=\"disc\">\n<li>\u5728 2023 \u5e74 11 \u6708\u4e3e\u884c\u7684\u7f8e\u56fd\u809d\u75c5\u7814\u7a76\u534f\u4f1a\u5e74\u4f1a\uff08AASLD\uff09\u4e0a\uff0c\u817e\u76db\u535a\u836f\u5c55\u793a\u4e86\u4e24\u4efd\u5173\u4e8eBRII-179\u7684\u7a81\u7834\u6027\u58c1\u62a5\uff0c\u63ed\u793a\u4e86HBsAg\u6e05\u9664\u7387\u4e0e\u4e59\u809d\u8868\u9762\u6297\u4f53\u53cd\u5e94\u4e4b\u95f4\u7684\u91cd\u8981\u8054\u7cfb\u3002\u8fd9\u4e9b\u6570\u636e\u4e3a\u8fdb\u4e00\u6b65\u63d0\u9ad8\u529f\u80fd\u6027\u6cbb\u6108\u7387\u548c\u8bc6\u522b\u6700\u6709\u53ef\u80fd\u5bf9\u6cbb\u6108\u6027\u7597\u6cd5\u4ea7\u751f\u5e94\u7b54\u7684\u60a3\u8005\u6307\u660e\u4e86\u65b9\u5411\u3002\n<ul type=\"disc\">\n<li>BRII-179\u53ef\u8bf1\u5bfc\u529f\u80fd\u6027\u514d\u75ab\u5e94\u7b54\uff0c\u63d0\u9ad8\u63a5\u53d7\u8054\u5408\u805a\u4e59\u4e8c\u9187\u5e72\u6270\u7d20\u03b1\uff08PEG-IFN\u03b1\uff09\u6cbb\u7597\u7684\u6162\u4e59\u809d\u60a3\u8005\u7684HBsAg\u6e05\u9664\u7387\u548c\u6e05\u9664\u6301\u7eed\u65f6\u95f4\uff0c\u8fdb\u800c\u53ef\u80fd\u63d0\u9ad8\u6162\u4e59\u809d\u60a3\u8005\u529f\u80fd\u6027\u6cbb\u6108\u7387\u3002<\/li>\n<li>\u817e\u76db\u535a\u836f\u5bf9BRII-179\u548cBRII-179\u8054\u5408BRII-835\uff08elebsiran\uff09\u5f00\u5c55\u76841b\/2a\u671f\u7814\u7a76\u7684\u8f6c\u5316\u7814\u7a76\u6570\u636e\u8868\u660e\uff0cBRII-179\u53ef\u80fd\u6709\u52a9\u4e8e\u8bc6\u522b\u51fa\u80fd\u591f\u4ea7\u751f\u5fc5\u8981HBV\u7279\u5f02\u6027\u514d\u75ab\u5e94\u7b54\u7684\u6162\u4e59\u809d\u60a3\u8005\uff0c\u4ece\u800c\u5728\u8fd9\u4e9b\u88ab\u7b5b\u9009\u51fa\u7684\u60a3\u8005\u4e2d\u5b9e\u73b0\u66f4\u9ad8\u7684\u529f\u80fd\u6027\u6cbb\u6108\u7387\uff0c\u540c\u65f6\u907f\u514d\u4e86\u5176\u4ed6\u60a3\u8005\u63a5\u53d7\u4e0d\u5fc5\u8981\u7684\u6cbb\u7597\u3002<\/li>\n<\/ul>\n<\/li>\n<li>\u817e\u76db\u535a\u836f\u8ba1\u5212\u57282024\u5e74\u4e0b\u534a\u5e74\u542f\u52a8\u591a\u9879\u8054\u5408\u7814\u7a76\uff0c\u4ee5\u9a8c\u8bc1BRII-179\u4e0e\u5176\u4ed6\u7597\u6cd5\u8054\u5408\u4f7f\u7528\u65f6\u63d0\u9ad8HBV\u529f\u80fd\u6027\u6cbb\u6108\u7387\u7684\u80fd\u529b\u3002<\/li>\n<li>\u817e\u76db\u535a\u836f\u5c06\u57282024\u5e743\u670827\u65e5\u81f331\u65e5\u4e8e\u65e5\u672c\u4eac\u90fd\u4e3e\u884c\u7684\u7b2c33\u5c4a\u4e9a\u592a\u809d\u810f\u7814\u7a76\u5b66\u4f1a\uff08APASL\uff09\u4f1a\u8bae\u4e0a\uff0c\u4ee5\u7a81\u7834\u6027\u53e3\u5934\u62a5\u544a\u7684\u5f62\u5f0f\u516c\u5e03\u5176\u6b63\u5728\u8fdb\u884c\u7684BRII-179\u8054\u5408PEG-IFN\u03b1\u6cbb\u7597\u6162\u4e59\u809d\u60a3\u8005\u7684 2 \u671f\u7814\u7a76\u4e2d\uff0c\u7b26\u5408\u6838\u82f7\u9178\u9006\u8f6c\u5f55\u9176\u6291\u5236\u5242\uff08NRTI\uff09\u505c\u836f\u6807\u51c6\u7684\u60a3\u8005\u6570\u636e\u3002<\/li>\n<\/ul>\n<\/li>\n<li><b>BRII-835\uff08E<\/b><b>lebsiran<\/b><b>\uff09<\/b><b>&amp; <\/b><b>BRII-877\uff08T<\/b><b>obevibart<\/b><b>\uff09<\/b><b>\u76f8\u5173\u7814\u7a76<\/b><b>\u548c<\/b><b>\u8ba1\u5212<\/b>\n<ul type=\"disc\">\n<li>\u5df2\u5b8c\u6210\u5728\u5305\u62ec\u4e2d\u56fd\u5927\u9646\u5728\u5185\u7684\u4e9a\u592a\u5730\u533a\u5f00\u5c55\u7684BRII-835\uff08elebsiran\uff09\u8054\u5408PEG-IFN\u03b1\u76842\u671f\u7814\u7a76\u60a3\u8005\u5165\u7ec4\u5de5\u4f5c\u3002\u8be5\u7814\u7a76\u65e8\u5728\u8fdb\u4e00\u6b65\u4e86\u89e3BRII-835\uff08elebsiran\uff09\u76f8\u8f83\u5355\u7528PEG-IFN\u03b1\u5bf9\u63d0\u9ad8HBV\u6cbb\u6108\u7387\u65b9\u9762\u7684\u6548\u679c\uff0c\u5e76\u63a2\u7d22BRII-179\u5728\u7b5b\u9009\u51fa\u5408\u9002\u7684\u60a3\u8005\u4ee5\u83b7\u5f97\u66f4\u4f73\u7597\u6548\u65b9\u9762\u7684\u6f5c\u529b\u3002\u8be5\u7814\u7a76\u7684\u521d\u6b65\u9876\u7ebf\u7ed3\u679c\u9884\u8ba1\u5c06\u4e8e2024\u5e74\u7b2c\u56db\u5b63\u5ea6\u516c\u5e03\u3002<\/li>\n<li>\u817e\u76db\u535a\u836f\u7684\u5408\u4f5c\u4f19\u4f34Vir Biotechnology, Inc.\uff08&quot;Vir&quot;\uff0c\u7eb3\u65af\u8fbe\u514b\u80a1\u7968\u4ee3\u7801\uff1aVIR\uff09\u57282023\u5e7411\u6708\u7684AASLD\u4f1a\u8bae\u4e0a\u5c55\u793a\u4e86MARCH\u7814\u7a76B\u90e8\u5206\u7684\u65b0\u6570\u636e\u3002\u6570\u636e\u663e\u793a\uff0c\u5728\u5c06BRII-877\uff08tobevibart\uff09\u52a0\u5165\u8054\u5408\u6216\u4e0d\u8054\u5408PEG-IFN\u03b1\u7684BRII-835\uff08elebsiran\uff09\u65b9\u6848\u4e2d\u6cbb\u759724\u5468\u540e\uff0c\u5e94\u7b54\u7387\u63d0\u9ad8\u4e86\u7ea6\u4e09\u500d\uff1a BRII-877\uff08tobevibart\uff09+ BRII-835\uff08elebsiran\uff09+ PEG-IFN\u03b1\u7684\u5e94\u7b54\u7387\u4e3a15.0%\uff0cBRII-877\uff08tobevibart\uff09+ BRII-835\uff08elebsiran\uff09\u7684\u5e94\u7b54\u7387\u4e3a14.3%\u3002\u6cbb\u759748\u5468\u7684\u961f\u5217\u6570\u636e\u5c06\u4e8e2024\u5e74\u7b2c\u56db\u5b63\u5ea6\u516c\u5e03\u3002<\/li>\n<li>Vir\u57282023\u5e7411\u6708AASLD\u4f1a\u8bae\u7684\u7a81\u7834\u6027\u62a5\u544a\u4e2d\uff0c\u4ee5\u53ca\u57282024\u5e741\u6708\u7b2c42\u5c4a\u6469\u6839\u5927\u901a\u533b\u7597\u5065\u5eb7\u5e74\u4f1a\u4e0a\uff0c\u5206\u4eab\u4e86SOLSTICE\u7814\u7a76\u4e2d\u4e00\u5c0f\u90e8\u5206\u6162\u6027\u4e01\u578b\u809d\u708e\uff08CHD\uff09\u53c2\u4e0e\u8005\u7684\u521d\u6b65\u6570\u636e\u3002\u7ecf\u8fc712\u5468\u7684BRII-877\uff08tobevibart\uff09\u548cBRII-835\uff08elebsiran\uff09\u8054\u5408\u6cbb\u7597\u540e\uff0c6\u540d\u53c2\u4e0e\u8005\u4e2d\u67095\u4eba\u65e0\u6cd5\u68c0\u6d4b\u5230\u4e01\u578b\u809d\u708e\u75c5\u6bd2\u6838\u7cd6\u6838\u9178\uff08HDV RNA\uff09\uff0c6\u540d\u53c2\u4e0e\u8005\u4e2d\u67096\u4eba\u7684HDV RNA\u4f4e\u4e8e\u5b9a\u91cf\u4e0b\u9650\u3002\u5176\u4ed6\u6570\u636e\u5c06\u4e8e2024\u5e74\u7b2c\u4e8c\u5b63\u5ea6\u516c\u5e03\uff0c\u5b8c\u6574\u768424\u5468\u6cbb\u7597\u6570\u636e\u9884\u8ba1\u5c06\u4e8e2024\u5e74\u7b2c\u56db\u5b63\u5ea6\u516c\u5e03\u3002<\/li>\n<li>BRII-877\uff08tobevibart\uff09\u7684\u4e00\u98791\u671f\u7814\u7a76\u6b63\u5728\u4e2d\u56fd\u5f00\u5c55\u3002\u4e2d\u56fd\u5927\u9646\u53d7\u8bd5\u8005\u7684\u4eba\u4f53\u836f\u4ee3\u52a8\u529b\u5b66\uff08PK\uff09\u6570\u636e\u5c06\u4e0e\u4e9a\u592a\u5730\u533a\u548c\u6b27\u6d32\u7684\u53d7\u8bd5\u8005\u8fdb\u884c\u6bd4\u8f83\u3002<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p><b><u>\u5176\u4ed6\u4e34\u5e8a\u548c\u4e34\u5e8a\u524d\u5f00\u53d1\u66f4\u65b0<\/u><\/b><\/p>\n<p>\u57fa\u4e8e\u516c\u53f8\u6240\u4e13\u6ce8\u7684HBV\u9879\u76ee\u6218\u7565\uff0c\u817e\u76db\u535a\u836f\u6b63\u5bfb\u6c42\u4ee5\u4e0b\u9879\u76ee\u540e\u7eed\u5f00\u53d1\u7684\u5408\u4f5c\u673a\u4f1a\u3002<\/p>\n<p><b><i>\u591a\u91cd\u8010\u836f\u548c\u5e7f\u6cdb\u8010\u836f\uff08<\/i><\/b><b><i>MDR\/XDR\uff09\u9769\u5170\u6c0f\u9634\u6027\u83cc\u611f\u67d3\u9879\u76ee<\/i><\/b><\/p>\n<ul type=\"disc\">\n<li><b>BRII-693<\/b>\n<ul type=\"disc\">\n<li>\u817e\u76db\u535a\u836f\u4e8e2023\u5e746\u6708\u83b7\u5f97\u4e86\u5f00\u53d1\u548c\u5546\u4e1a\u5316BRII-693\u7684\u5168\u7403\u72ec\u5bb6\u6743\u76ca\uff0cBRII-693\u662f\u4e00\u79cd\u65b0\u578b\u591a\u7c98\u83cc\u7d20\uff0c\u7528\u4e8e\u6cbb\u7597\u4e25\u91cd\u7684\u9769\u5170\u6c0f\u9634\u6027\u611f\u67d3\u3002\u516c\u53f8\u6b63\u5bfb\u6c42\u6218\u7565\u8d44\u91d1\u5408\u4f5c\u4f19\u4f34\uff0c\u4ee5\u52a0\u5febBRII-693\u7684\u5f00\u53d1\uff0c\u8fd9\u79cd\u65b0\u578b\u6297\u751f\u7d20\u65e8\u5728\u5e2e\u52a9\u5e94\u5bf9\u5168\u7403\u65e5\u76ca\u4e25\u5cfb\u7684\u6297\u83cc\u836f\u8010\u836f\u5a01\u80c1\u3002<\/li>\n<li>2023\u5e744\u6708\uff0c\u817e\u76db\u535a\u836f\u5411NMPA\u63d0\u4ea4\u4e86BRII-693\u7684pre-IND\u7533\u8bf7\uff0c\u8ba1\u5212\u5728\u4e2d\u56fd\u542f\u52a81\u671f\u4e34\u5e8aPK\u6865\u63a5\u7814\u7a76\u3002\u516c\u53f8\u6b63\u8ba1\u5212\u5f00\u5c55\u66f4\u591aPK\u4e34\u5e8a\u7814\u7a76\uff0c\u4ee5\u652f\u63013\u671f\u4e34\u5e8a\u8bd5\u9a8c\u7684\u542f\u52a8\u3002\u8fd9\u4e9b\u7814\u7a76\u5bf9\u652f\u6301\u5168\u7403\u5f00\u53d1\u5de5\u4f5c\u81f3\u5173\u91cd\u8981\u3002\u9488\u5bf9\u533b\u9662\u83b7\u5f97\u6027\u7ec6\u83cc\u6027\u80ba\u708e\uff08HABP\uff09\/\u547c\u5438\u673a\u76f8\u5173\u7ec6\u83cc\u6027\u80ba\u708e\uff08VABP\uff09\u7684\u5927\u578b\u5168\u74033\u671f\u6ce8\u518c\u6027\u4e34\u5e8a\u8bd5\u9a8c\u9884\u8ba1\u5c06\u4e8e2025\u5e74\u5f00\u5c55\u3002<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p><b><i>\u4eba\u7c7b\u514d\u75ab\u7f3a\u9677\u75c5\u6bd2\uff08<\/i><\/b><b><i>HIV\uff09\u9879\u76ee<\/i><\/b><\/p>\n<ul type=\"disc\">\n<li><b>BRII-753<\/b>\u662f\u516c\u53f8\u5185\u90e8\u7814\u53d1\u7684\u65b0\u5316\u5b66\u5b9e\u4f53\uff0c\u76ee\u524d\u6b63\u5904\u4e8e\u4e34\u5e8a\u524d\u5f00\u53d1\u9636\u6bb5\u3002BRII-753\u662f\u4e00\u79cd\u957f\u6548\u76ae\u4e0b\u6ce8\u5c04\u5242\uff0c\u53ef\u6bcf\u6708\u4e00\u6b21\u3001\u6bcf\u5b63\u5ea6\u4e00\u6b21\u6216\u6bcf\u5e74\u4e24\u6b21\u7ed9\u836f\uff0c\u53ef\u7528\u4e8e\u6cbb\u7597HIV\u7684\u8054\u5408\u7597\u6cd5\u548c\u66b4\u9732\u524d\u9884\u9632\u7684\u5355\u836f\u7597\u6cd5\u3002<\/li>\n<li><b>BRII-732<\/b>\u5df2\u5b8c\u62101\u671f\u7814\u7a76\uff0c\u6709\u6f5c\u529b\u5f00\u53d1\u4e3aHIV\u60a3\u8005\u6bcf\u5468\u53e3\u670d\u4e00\u6b21\u7684\u957f\u6548\u8054\u5408\u6cbb\u7597\u65b9\u6848\u7684\u4e00\u90e8\u5206\u3002<\/li>\n<\/ul>\n<p><i><b>\u975e\u7ed3\u6838\u5206\u679d\u6746\u83cc\uff08<\/b><\/i><i><b>NTM\uff09\u80ba\u75c5\u9879\u76ee<\/b><\/i><\/p>\n<ul type=\"disc\">\n<li><b>BRII-658\uff08Epetraborole\uff09\uff1a<\/b>2024\u5e742\u6708\uff0c\u817e\u76db\u535a\u836f\u7684\u5408\u4f5c\u4f19\u4f34AN2 Therapeutics, Inc.\uff08\u7eb3\u65af\u8fbe\u514b\u80a1\u7968\u4ee3\u7801\uff1aANTX\uff09\u5ba3\u5e03\u81ea\u613f\u6682\u505c\u5176epetraborole\uff08BRII-658\uff09\u6cbb\u7597\u96be\u6cbb\u6027\u590d\u5408\u5206\u679d\u6746\u83cc\uff08MAC\uff09\u80ba\u75c5\u76842\/3 \u671f\u4e34\u5e8a\u8bd5\u9a8c\u60a3\u8005\u62db\u52df\uff0c\u4ee5\u5f85\u8fdb\u4e00\u6b65\u7684\u6570\u636e\u5ba1\u67e5\u3002<\/li>\n<\/ul>\n<p><b><i>\u4ea7\u540e\u6291\u90c1\u75c7\uff08<\/i><\/b><b><i>PPD\uff09\u548c\u91cd\u5ea6\u6291\u90c1\u75c7\uff08MDD\uff09\u9879\u76ee<\/i><\/b><\/p>\n<ul type=\"disc\">\n<li><b>BRII-296\uff1a<\/b>2023\u5e749 \u6708\uff0c\u8bc4\u4f30BRII-296\u76842\u671f\u7814\u7a76\u5b8c\u6210\u9996\u4f8b\u60a3\u8005\u7ed9\u836f\u3002BRII-296\u662f\u4e00\u79cd\u957f\u6548\u6ce8\u5c04\u5242\uff0c\u6b63\u5728\u5f00\u53d1\u7528\u4e8e\u6cbb\u7597PPD\u3002\u516c\u53f8\u9884\u8ba1\u5c06\u4e8e2024\u5e74\u7b2c\u4e8c\u5b63\u5ea6\u516c\u5e032\u671f\u8bd5\u9a8c\u6570\u636e\u3002<\/li>\n<li><b>BRII-297<\/b>\u662f\u4e00\u79cd\u957f\u6548\u6ce8\u5c04\u5242\uff0c\u6b63\u5728\u5f00\u53d1\u7528\u4e8e\u6cbb\u7597\u7126\u8651\u75c7\u548c\u6291\u90c1\u75c7\uff0c\u8be5\u836f\u76841\u671f\u4e34\u5e8a\u8bd5\u9a8c\u5df2\u5b8c\u6210\u60a3\u8005\u7ed9\u836f\u3002\u8be5\u7814\u7a76\u65e8\u5728\u8bc4\u4f30BRII-297\u5728\u5065\u5eb7\u5fd7\u613f\u8005\u4e2d\u7684\u5b89\u5168\u6027\u3001\u8010\u53d7\u6027\u548c\u836f\u4ee3\u52a8\u529b\u5b66\uff0c\u9884\u8ba1\u5c06\u4e8e2024\u5e74\u4e0b\u534a\u5e74\u83b7\u5f97\u6570\u636e\u3002<\/li>\n<\/ul>\n<p><b><u>2023\u5e74\u5168\u5e74\u8d22\u52a1\u4e1a\u7ee9<\/u><\/b><\/p>\n<ul type=\"disc\">\n<li>\u622a\u81f32023\u5e7412\u670831\u65e5\uff0c\u94f6\u884c\u5b58\u6b3e\u4ee5\u53ca\u73b0\u91d1\u53ca\u73b0\u91d1\u7b49\u4ef7\u7269\u4e3a\u4eba\u6c11\u5e0126.614\u4ebf\u5143\uff0c\u4e0e\u622a\u81f32022 \u5e7412\u670831\u65e5\u7684\u4eba\u6c11\u5e0129.993\u4ebf\u5143\u76f8\u6bd4\uff0c\u51cf\u5c11\u4eba\u6c11\u5e013.379\u4ebf\u5143\u621611.3%\u3002\u8be5\u51cf\u5c11\u4e3b\u8981\u662f\u7531\u4e8e\u65e5\u5e38\u8425\u8fd0\u53ca\u7814\u53d1\u6d3b\u52a8\u652f\u51fa\u3002<\/li>\n<li>\u622a\u81f32023\u5e7412\u670831\u65e5\u6b62\u5e74\u5ea6\uff0c\u5176\u4ed6\u6536\u5165\u4e3a\u4eba\u6c11\u5e011.637\u4ebf\u5143\uff0c\u4e0e\u622a\u81f32022 \u5e7412\u670831\u65e5\u6b62\u5e74\u5ea6\u7684\u4eba\u6c11\u5e011.079\u4ebf\u5143\u76f8\u6bd4\uff0c\u589e\u52a0\u4eba\u6c11\u5e015,580\u4e07\u5143\u621651.7%\u3002\u8fd9\u4e3b\u8981\u662f\u7531\u4e8e\u7f8e\u5143\u53ca\u6e2f\u5143\u5b9a\u671f\u5b58\u6b3e\u5229\u7387\u4e0a\u5347\u5bfc\u81f4\u94f6\u884c\u5229\u606f\u6536\u5165\u589e\u52a0\u4eba\u6c11\u5e017,080\u4e07\u5143\u3002\u8be5\u589e\u52a0\u90e8\u5206\u88ab\u786e\u8ba4\u7684\u4e2d\u56fd\u653f\u5e9c\u8865\u52a9\u6536\u5165\u51cf\u5c11\u6240\u62b5\u9500\u3002<\/li>\n<li>\u622a\u81f32023\u5e7412\u670831\u65e5\u6b62\u5e74\u5ea6\uff0c\u7814\u53d1\u5f00\u652f\u4e3a\u4eba\u6c11\u5e014.027\u4ebf\u5143\uff0c\u4e0e\u622a\u81f3 2022\u5e7412\u670831\u65e5\u6b62\u5e74\u5ea6\u7684\u4eba\u6c11\u5e014.406\u4ebf\u5143\u76f8\u6bd4\uff0c\u51cf\u5c11\u4eba\u6c11\u5e013,790\u4e07\u5143\u62168.6%\u3002\u8be5\u51cf\u5c11\u4e3b\u8981\u662f\u7531\u4e8eCOVID-19\u9879\u76ee\u7ec8\u6b62\u3002<\/li>\n<li>\u622a\u81f32023\u5e7412\u670831\u65e5\u6b62\u5e74\u5ea6\uff0c\u884c\u653f\u5f00\u652f\u4e3a\u4eba\u6c11\u5e011.965\u4ebf\u5143\uff0c\u4e0e\u622a\u81f3 2022\u5e7412\u670831\u65e5\u6b62\u5e74\u5ea6\u7684\u4eba\u6c11\u5e011.686\u4ebf\u5143\u76f8\u6bd4\uff0c\u589e\u52a0\u4eba\u6c11\u5e012,790\u4e07\u5143\u621616.5%\u3002\u8be5\u589e\u52a0\u4e3b\u8981\u5f52\u56e0\u4e8e\u96c7\u5458\u6210\u672c\u589e\u52a0\u3002<\/li>\n<li>\u622a\u81f32023\u5e7412\u670831\u65e5\u6b62\u5e74\u5ea6\uff0c\u7efc\u5408\u5f00\u652f\u603b\u989d\u4e3a\u4eba\u6c11\u5e011.597\u4ebf\u5143\uff0c\u4e0e\u622a\u81f32022\u5e7412\u670831\u65e5\u6b62\u5e74\u5ea6\u7684\u4eba\u6c11\u5e012.385\u4ebf\u5143\u76f8\u6bd4\uff0c\u51cf\u5c11\u4eba\u6c11\u5e017,880\u4e07\u5143\u6216<span id=\"spanHghlt02a7\">33.0%<\/span>\u3002\u8be5\u51cf\u5c11\u4e3b\u8981\u5f52\u56e0\u4e8e\u5176\u4ed6\u6536\u76ca\u53ca\u4e8f\u635f\u589e\u52a0\uff0c\u90e8\u5206\u88ab\u7531\u529f\u80fd\u8d27\u5e01\u6362\u7b97\u81f3\u5448\u5217\u8d27\u5e01\u7684\u6c47\u5151\u5dee\u989d\u6240\u4ea7\u751f\u7684\u6536\u76ca\u51cf\u5c11\u6240\u62b5\u9500\u3002<\/li>\n<\/ul>\n<p><b><u>\u7535\u8bdd\u4f1a\u8bae\u4fe1\u606f<\/u><\/b><\/p>\n<p>\u516c\u53f8\u5c06\u4e8e2024\u5e743\u670825\u65e5\uff0c\u9999\u6e2f\u65f6\u95f4\u4e0a\u53488:30\uff08\u7f8e\u56fd\u4e1c\u90e8\u65f6\u95f43\u670824\u65e5\u665a\u95f48:30\uff09\u4e3e\u884c\u7535\u8bdd\u4f1a\u8bae\uff08\u4e2d\u6587\u573a\uff09\u3002\u5728\u53c2\u52a0\u7535\u8bdd\u4f1a\u8bae\u4e4b\u524d\uff0c\u53c2\u4f1a\u8005\u987b\u5b8c\u6210\u4f1a\u8bae\u6ce8\u518c\u3002\u6ce8\u518c\u94fe\u63a5\u8bf7\u70b9\u51fb<a href=\"https:\/\/s.comein.cn\/AkJjn\" target=\"_blank\" rel=\"nofollow noopener\">\u8fd9\u91cc<\/a>\u3002<\/p>\n<p>\u6240\u6709\u53c2\u4f1a\u8005\u987b\u5728\u7535\u8bdd\u4f1a\u8bae\u4e4b\u524d\u901a\u8fc7\u4e0a\u8ff0\u94fe\u63a5\u5b8c\u6210\u5728\u7ebf\u6ce8\u518c\u3002\u6b64\u5916\uff0c\u6b64\u7535\u8bdd\u4f1a\u8bae\u7684\u56de\u653e\u5c06\u5728\u4f1a\u8bae\u540e\u63d0\u4f9b\uff0c\u5e76\u53ef\u901a\u8fc7\u8bbf\u95ee\u516c\u53f8\u7f51\u7ad9<a href=\"https:\/\/www.briibio.com\/\" target=\"_blank\" rel=\"nofollow noopener\">www.briibio.com<\/a>\u7684\u6295\u8d44\u8005\u5173\u7cfb\u7248\u5757\u83b7\u53d6\u3002<\/p>\n<p class=\"prntac\">***<\/p>\n<p>\u672c\u65b0\u95fb\u7a3f\u6d89\u53ca\u7b2c\u4e09\u65b9\u4fe1\u606f\u7684\u5f15\u7528\u3002\u6b64\u7c7b\u4fe1\u606f\u4e0d\u5e94\u88ab\u89c6\u4e3a\u53c2\u8003\u4fe1\u606f\u7eb3\u5165\u672c\u65b0\u95fb\u7a3f\u4e2d\u3002\u817e\u76db\u535a\u836f\u5bf9\u6b64\u7c7b\u7b2c\u4e09\u65b9\u4fe1\u606f\u7684\u4e0d\u8d1f\u4efb\u4f55\u8d23\u4efb\u3002<\/p>\n<p><b>\u5173\u4e8e\u817e\u76db\u535a\u836f<\/b><\/p>\n<p>\u817e\u76db\u535a\u836f\uff08\u80a1\u7968\u4ee3\u7801\uff1a2137.HK\uff09\u662f\u4e00\u5bb6\u751f\u7269\u6280\u672f\u516c\u53f8\uff0c\u81f4\u529b\u4e8e\u9488\u5bf9\u5b58\u5728\u5de8\u5927\u672a\u88ab\u6ee1\u8db3\u7684\u60a3\u8005\u9700\u6c42\u3001\u6cbb\u7597\u624b\u6bb5\u6709\u9650\uff0c\u4ee5\u53ca\u7ed9\u60a3\u8005\u5e26\u6765\u4e25\u91cd\u793e\u4f1a\u6b67\u89c6\u7684\u91cd\u5927\u516c\u5171\u536b\u751f\u6311\u6218\u5f00\u53d1\u521b\u65b0\u7597\u6cd5\u3002\u516c\u53f8\u4e13\u6ce8\u4e8e\u611f\u67d3\u6027\u75be\u75c5\u548c\u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf\u75be\u75c5\uff0c\u6b63\u5728\u63a8\u8fdb\u4e00\u6761\u6db5\u76d6\u591a\u79cd\u72ec\u7279\u5019\u9009\u836f\u7269\u7684\u4ea7\u54c1\u7ba1\u7ebf\uff0c\u5e76\u901a\u8fc7\u9886\u5148\u7684\u9879\u76ee\u5f00\u53d1\u9488\u5bf9\u4e59\u578b\u809d\u708e\u75c5\u6bd2\uff08HBV\uff09\u611f\u67d3\u7684\u65b0\u578b\u529f\u80fd\u6027\u6cbb\u6108\u65b9\u6848\uff0c\u548c\u9488\u5bf9\u4ea7\u540e\u6291\u90c1\u75c7\uff08PPD\uff09\u4ee5\u53ca\u91cd\u5ea6\u6291\u90c1\u75c7\uff08MDD\uff09\u7684\u9996\u521b\u6cbb\u7597\u65b9\u6848\u3002\u5728\u5bcc\u6709\u8fdc\u89c1\u5353\u8bc6\u548c\u7ecf\u9a8c\u4e30\u5bcc\u7684\u9886\u5bfc\u56e2\u961f\u5e26\u9886\u4e0b\uff0c\u516c\u53f8\u5728\u4f4d\u4e8e\u7f57\u5229-\u8fbe\u52d2\u59c6\u3001\u65e7\u91d1\u5c71\u6e7e\u533a\u3001\u5317\u4eac\u548c\u4e0a\u6d77\u7684\u4e3b\u8981\u751f\u7269\u6280\u672f\u4e2d\u5fc3\u5f00\u5c55\u4e1a\u52a1\u3002\u6b32\u4e86\u89e3\u66f4\u591a\u4fe1\u606f\uff0c\u8bf7\u8bbf\u95ee<a href=\"http:\/\/www.briibio.com\/\" target=\"_blank\" rel=\"nofollow 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