{"id":108241,"date":"2024-03-19T07:00:00","date_gmt":"2024-03-19T00:00:00","guid":{"rendered":"https:\/\/www.xinwengao.com\/cn\/pr\/20240319070000108241"},"modified":"2024-03-20T00:23:51","modified_gmt":"2024-03-19T16:23:51","slug":"%e4%bf%a1%e8%be%be%e7%94%9f%e7%89%a9%e5%ae%a3%e5%b8%83ibi302%ef%bc%88%e6%8a%97vegf-%e8%a1%a5%e4%bd%93%ef%bc%89%e6%b2%bb%e7%96%97%e6%96%b0%e7%94%9f%e8%a1%80%e7%ae%a1%e6%80%a7%e5%b9%b4%e9%be%84%e7%9b%b8","status":"publish","type":"post","link":"https:\/\/www.xinwengao.com\/cn\/pr\/20240319070000108241","title":{"rendered":"\u4fe1\u8fbe\u751f\u7269\u5ba3\u5e03IBI302\uff08\u6297VEGF\/\u8865\u4f53\uff09\u6cbb\u7597\u65b0\u751f\u8840\u7ba1\u6027\u5e74\u9f84\u76f8\u5173\u6027\u9ec4\u6591\u53d8\u6027\uff08nAMD\uff09\u7684\u7b2c\u4e8c\u9879II\u671f\u4e34\u5e8a\u7814\u7a76\u8fbe\u6210\u4e3b\u8981\u7ec8\u70b9"},"content":{"rendered":"

\u7f8e\u56fd\u7f57\u514b\u7ef4\u5c14\u548c\u4e2d\u56fd\u82cf\u5dde<\/span>2024\u5e743\u670819\u65e5<\/span> \/\u7f8e\u901a\u793e\/ — \u4fe1\u8fbe\u751f\u7269\u5236\u836f\u96c6\u56e2\uff08\u9999\u6e2f\u8054\u4ea4\u6240\u80a1\u7968\u4ee3\u7801\uff1a01801\uff09\uff0c\u4e00\u5bb6\u81f4\u529b\u4e8e\u7814\u53d1\u3001\u751f\u4ea7\u548c\u9500\u552e\u80bf\u7624\u3001\u81ea\u8eab\u514d\u75ab\u3001\u4ee3\u8c22\u53ca\u5fc3\u8840\u7ba1\u3001\u773c\u79d1\u7b49\u91cd\u5927\u75be\u75c5\u9886\u57df\u521b\u65b0\u836f\u7269\u7684\u751f\u7269\u5236\u836f\u516c\u53f8\uff0c\u4eca\u65e5\u5ba3\u5e03\u5176\u7814\u53d1\u7684\u91cd\u7ec4\u4eba\u8840\u7ba1\u5185\u76ae\u751f\u957f\u56e0\u5b50\u53d7\u4f53\uff08VEGFR\uff09-\u6297\u4f53-\u4eba\u8865\u4f53\u53d7\u4f531 (CR1) \u878d\u5408\u86cb\u767dEfdamrofusp alfa\u6ce8\u5c04\u6db2\uff08\u7814\u53d1\u4ee3\u53f7\uff1aIBI302\uff09\u5728\u4e2d\u56fd\u65b0\u751f\u8840\u7ba1\u6027\u5e74\u9f84\u76f8\u5173\u6027\u9ec4\u6591\u53d8\u6027\uff08neovascular age-related macular degeneration, nAMD\uff09\u53d7\u8bd5\u8005\u4e2d\u5f00\u5c55\u7684\u7b2c\u4e8c\u9879IBI302 (\u9ad8\u5242\u91cf)\u7684II\u671f\u4e34\u5e8a\u7814\u7a76\u8fbe\u5230\u4e3b\u8981\u7ec8\u70b9\u3002<\/p>\n

\u5df2\u5f00\u5c55\u7684\u5171\u5165\u7ec4\u8d85360\u4f8b\u53d7\u8bd5\u8005\u7684\u4e24\u9879II\u671f\u4e34\u5e8a\u7814\u7a76\u7ed3\u679c\u63d0\u793a\uff0c\u76f8\u8f83\u963f\u67cf\u897f\u666e\uff0cIBI302\u53ef\u5728\u957f\u95f4\u9694\u7ed9\u836f\uff083\u4e2a\u6708\u53ca\u4ee5\u4e0a\uff09\u4e0b\u5e26\u6765\u7a33\u5b9a\u7684\u89c6\u529b\u83b7\u76ca\u548c\u89e3\u5256\u5b66\u7597\u6548\u6539\u5584\uff0c\u5e76\u89c2\u5bdf\u5230\u5bf9\u9ec4\u6591\u840e\u7f29\u7684\u6f5c\u5728\u6539\u5584\u4f5c\u7528\u3002\u6b64\u524d\uff0c\u4fe1\u8fbe\u751f\u7269\u5df2\u4e8e2023\u5e7410\u6708\u542f\u52a8\u4e86IBI302 8mg\u7528\u4e8e\u6cbb\u7597nAMD\u7684III\u671f\u4e34\u5e8a\u7814\u7a76\uff08STAR\uff09\u3002<\/p>\n

\u672c\u6b21\u8fbe\u5230\u7ec8\u70b9\u7684\u662f\u4e00\u9879\u5728nAMD\u53d7\u8bd5\u8005\u4e2d\u8bc4\u4f30\u957f\u95f4\u9694\u73bb\u7483\u4f53\u8154\u6ce8\u5c04IBI302\u7684\u7597\u6548\u548c\u5b89\u5168\u6027\u7684\u968f\u673a\u3001\u53cc\u76f2\u3001\u6d3b\u6027\u5bf9\u7167\u7684II\u671f\u4e34\u5e8a\u7814\u7a76\uff08NCT05403749\uff09\u3002132\u4f8b\u53d7\u8bd5\u8005\u4ee51:1:1\u968f\u673a\u5206\u914d\u81f3IBI302 6.4 mg\u7ec4\u3001IBI302 8.0mg\u7ec4\u3001\u963f\u67cf\u897f\u666e 2.0mg\u7ec4\u3002IBI302 6.4 mg\u7ec4\u548c8.0 mg\u7ec4\u5728\u8d1f\u8377\u6cbb\u7597\u9636\u6bb5\u540e\u6839\u636e\u6cbb\u7597\u53cd\u5e94\u8c03\u6574\u81f3\u6bcf8\u5468\uff08Q8W\uff09\u6216\u6bcf12\u5468\uff08Q12W\uff09\u7ed9\u836f1\u6b21\u3002\u963f\u67cf\u897f\u666e2.0mg\u7ec4\u8d1f\u8377\u6cbb\u7597\u540e\uff0c\u6309\u7167Q8W\u6cbb\u7597\u3002\u8be5\u8bd5\u9a8c\u7684\u4e3b\u8981\u7ec8\u70b9\u6307\u6807\u4e3a\u5728\u7b2c40\u5468\u65f6\uff0c\u7814\u7a76\u773c\u6700\u4f73\u77eb\u6b63\u89c6\u529b\uff08best corrected visual acuity, BCVA\uff09\u8bc4\u5206\u8f83\u57fa\u7ebf\u7684\u6539\u53d8\u3002\u7814\u7a76\u603b\u5468\u671f\u4e3a52\u5468\u3002<\/p>\n

\u7814\u7a76\u7ed3\u679c\u663e\u793a\u987a\u5229\u8fbe\u6210\u4e3b\u8981\u7ec8\u70b9\uff1a\u7b2c40\u5468\u65f6\uff0cIBI302 6.4 mg\u7ec4\u4e0e8.0 mg\u7ec4\u7814\u7a76\u773cBCVA\u8f83\u57fa\u7ebf\u6539\u5584\u503c\u975e\u52a3\u6548\u4e8e\u963f\u67cf\u897f\u666e2.0 mg\u7ec4\u3002\u7b2c40\u5468\u65f6\uff0cIBI302 6.4 mg\u7ec4\u3001IBI302 8.0 mg\u7ec4\u3001\u963f\u67cf\u897f\u666e 2.0 mg\u7ec4BCVA\u8f83\u57fa\u7ebf\u63d0\u9ad8\u7684\u5747\u503c\u5206\u522b\u4e3a10.5\u300111.0\u30019.8\u4e2aETDRS\u5b57\u6bcd\u6570\u3002<\/p>\n

\u5728\u89e3\u5256\u5b66\u7597\u6548\u7ec8\u70b9\u4e0a\uff0c\u7b2c40\u5468\u65f6\uff0cIBI302 6.4 mg\u7ec4\u4e0e8.0 mg\u7ec4\u4e2d\u592e\u89c6\u7f51\u819c\u539a\u5ea6\uff08central subfield thickness, CST\uff09\u8f83\u57fa\u7ebf\u6539\u5584\u7684\u5747\u503c\u5206\u522b\u4e3a-163.19 \u03bcm\u3001-184.46 \u03bcm\uff0c\u963f\u67cf\u897f\u666e 2.0 mg\u7ec4\u4e3a-108.23 \u03bcm\u3002<\/p>\n

\u6b64\u5916\uff0c6.4mg IBI302\u7ec4\u4e0e8.0mg IBI302\u7ec4\u7ef4\u6301Q12W\u7ed9\u836f\u95f4\u9694\u7684\u53d7\u8bd5\u8005\u6bd4\u4f8b\u5206\u522b\u4e3a81%\u300188%\u3002\u95f4\u63a5\u6bd4\u8f83\uff0c\u4e0e\u963f\u67cf\u897f\u666e 8.0 mg\uff08PULSAR\u8bd5\u9a8c\u4e3a83%\uff09[1]<\/span><\/sup>\u548c\u6cd5\u745e\u897f\u5355\u6297\uff08TENAYA\u8bd5\u9a8c&LUCERNE\u8bd5\u9a8c\u5206\u522b\u4e3a79.7%\uff0c77.8%\uff09[2]<\/span><\/sup>\u7684Q12W\u53ca\u4ee5\u4e0a\u95f4\u9694\u7684\u53d7\u8bd5\u8005\u6bd4\u4f8b\u76f8\u4f3c\u3002\u57fa\u4e8eII\u671f\u4e2d\u4f18\u5f02\u7684\u957f\u95f4\u9694\u7ed9\u836f\u6548\u679c\uff0c\u5728III\u671f\u4e34\u5e8a\u7814\u7a76\uff08STAR\uff09\u589e\u52a0\u4e86IBI302\u7ef4\u6301Q16W\u7ed9\u836f\u95f4\u9694\u7684\u6cbb\u7597\u961f\u5217\u3002<\/p>\n

\u7814\u7a76\u671f\u95f4IBI302\u6574\u4f53\u5b89\u5168\u6027\u826f\u597d\uff0c\u4e0e\u963f\u67cf\u897f\u666e2.0 mg\u7ec4\u76f8\u4f3c\u3002IBI302\u5b89\u5168\u6027\u7279\u5f81\u4e0e\u65e2\u5f80\u7814\u7a76\u4e00\u81f4\uff0c\u672a\u53d1\u73b0\u65b0\u7684\u5b89\u5168\u6027\u4fe1\u53f7\u3002\u8be6\u7ec6\u7814\u7a76\u6570\u636e\u5c06\u8fdb\u4e00\u6b65\u5206\u6790\u53d1\u5e03\u3002<\/p>\n

\u8be5\u4e34\u5e8a\u7814\u7a76\u7684\u4e3b\u8981\u7814\u7a76\u8005\uff0c\u4e0a\u6d77\u5e02\u7b2c\u4e00\u4eba\u6c11\u533b\u9662\u56fd\u5bb6\u773c\u90e8\u75be\u75c5\u4e34\u5e8a\u533b\u5b66\u4e2d\u5fc3\u4e3b\u4efb\u5b59\u6653\u4e1c\u6559\u6388<\/b>\u8868\u793a\uff1a"\u73bb\u7483\u4f53\u8154\u6ce8\u5c04\u6297VEGF\u7c7b\u836f\u7269\u662f\u5f53\u524d\u6cbb\u7597\u65b0\u751f\u8840\u7ba1\u6027\u5e74\u9f84\u76f8\u5173\u6027\u9ec4\u6591\u53d8\u6027\uff08nAMD\uff09\u7684\u4e00\u7ebf\u6cbb\u7597\u65b9\u6848\uff0c\u4f46\u4ecd\u5b58\u5728\u9700\u8981\u9891\u7e41\u6ce8\u5c04\u3001\u968f\u8bbf\u4e2d\u89c6\u529b\u83b7\u76ca\u9010\u6e10\u4e22\u5931\u7b49\u672a\u6ee1\u8db3\u4e34\u5e8a\u9700\u6c42\uff0c\u63a2\u7d22\u957f\u95f4\u9694\u7ed9\u836f\u548c\u6297\u9ec4\u6591\u840e\u7f29\u662f\u836f\u7269\u7814\u53d1\u7684\u65b0\u8d8b\u52bf\u3002IBI302\u662f\u5168\u7403\u9996\u521b\u6297VEGF-\u6297\u8865\u4f53\u53cc\u9776\u70b9\u5206\u5b50\uff0c\u4f5c\u4e3aIBI302\u7cfb\u5217\u7814\u7a76\u7684\u4e3b\u8981\u7814\u7a76\u8005\uff0c\u6211\u975e\u5e38\u6b23\u559c\u5730\u770b\u5230\u9ad8\u5242\u91cfIBI302\u5728II\u671f\u7814\u7a76\u4e2d\u8fbe\u5230\u4e3b\u8981\u7814\u7a76\u7ec8\u70b9\u76ee\u6807\u5e76\u5c55\u73b0\u51fa\u957f\u95f4\u9694\u7ed9\u836f\u7684\u6f5c\u529b\uff0c\u8fd9\u4e0e\u4f4e\u5242\u91cfIBI302\u7684II\u671f\u7ed3\u679c\u4e00\u81f4\uff0c\u975e\u5e38\u4ee4\u4eba\u60ca\u559c\u3002\u6211\u975e\u5e38\u671f\u5f85\u8fd9\u4e9b\u7ed3\u679c\u80fd\u8fdb\u4e00\u6b65\u5728IBI302\u7684\u5173\u952e\u6ce8\u518c\u7814\u7a76\u4e2d\u5f97\u5230\u9a8c\u8bc1\uff0c\u4e3anAMD\u7684\u6cbb\u7597\u63d0\u4f9b\u65b0\u7684\u9009\u62e9\u3002"<\/p>\n

\u4fe1\u8fbe\u751f\u7269\u5236\u836f\u96c6\u56e2\u4e34\u5e8a\u5f00\u53d1\u526f\u603b\u88c1\u94b1\u956d\u535a\u58eb<\/b>\u8868\u793a\uff1a"\u5ef6\u957f\u7ed9\u836f\u95f4\u9694\u548c\u51cf\u5c11\u9ec4\u6591\u840e\u7f29\u7684\u53d1\u751f\uff0c\u662f\u76ee\u524dnAMD\u836f\u7269\u7814\u53d1\u7684\u4e24\u5927\u65b9\u5411\u4e0e\u8d8b\u52bf\u3002\u5728\u4e24\u9879\u5171\u5165\u7ec4\u8d85360\u4f8b\u53d7\u8bd5\u8005\u7684\u4e8c\u671f\u7814\u7a76\u7ed3\u679c\u4e2d\uff0cIBI302\u5c55\u73b0\u51fa\u663e\u8457\u6539\u5584nAMD\u60a3\u8005\u7684BCVA\u548c\u9ec4\u6591\u6c34\u80bf\uff0c\u660e\u663e\u5ef6\u957f\u7ed9\u836f\u95f4\u9694\uff0c\u4e14\u5177\u6709\u9884\u9632\u9ec4\u6591\u840e\u7f29\u53d1\u751f\u7684\u6f5c\u529b\u3002\u63a5\u4e0b\u6765\u6211\u4eec\u5c06\u5728III\u671f\u4e34\u5e8a\u7814\u7a76STAR\u4e2d\u8fdb\u4e00\u6b65\u63a2\u7d22\u9ad8\u5242\u91cfIBI302\u957f\u95f4\u9694\u7ed9\u836f\u7684\u7597\u6548\u548c\u5b89\u5168\u6027\uff0c\u671f\u5f85\u7ed9nAMD\u60a3\u8005\u5e26\u6765\u65b0\u4e00\u4ee3\u6297VEGF\u836f\u7269\u3002"<\/p>\n

\u5173\u4e8e\u65b0\u751f\u8840\u7ba1\u6027\u5e74\u9f84\u76f8\u5173\u6027\u9ec4\u6591\u53d8\u6027\uff08<\/b>nAMD<\/b>\uff09<\/b><\/p>\n

\u5e74\u9f84\u76f8\u5173\u6027\u9ec4\u6591\u53d8\u6027\uff08AMD\uff09\u662f\u7d2f\u53ca\u9ec4\u6591\u533a\u89c6\u7f51\u819c\uff0c\u5bfc\u81f4\u4e2d\u592e\u89c6\u529b\u635f\u5bb3\u7684\u8fdb\u5c55\u6027\u773c\u90e8\u75be\u75c5\uff0c\u53d1\u75c5\u7387\u968f\u5e74\u9f84\u589e\u52a0\u800c\u5347\u9ad8\u3002\u65b0\u751f\u8840\u7ba1\u6027\u5e74\u9f84\u76f8\u5173\u6027\u9ec4\u6591\u53d8\u6027\uff08nAMD\uff09\u662fAMD\u7684\u4e3b\u8981\u7c7b\u578b\u4e4b\u4e00\uff0c\u5360\u6240\u6709AMD\u60a3\u8005\u768415%~20%\uff0c\u4e5f\u662f\u9020\u621065\u5c81\u4ee5\u4e0a\u7684AMD\u60a3\u8005\u4e2d\u5fc3\u89c6\u529b\u4e27\u5931\u7684\u6700\u4e3b\u8981\u539f\u56e0[3]<\/span><\/sup>\u3002AMD\u5728\u6211\u56fd\u53d1\u75c5\u7387\u5448\u9010\u5e74\u4e0a\u5347\u7684\u8d8b\u52bf\uff0c\u73b0\u5df2\u8dc3\u5c45\u6211\u56fd\u7b2c\u4e09\u5927\u81f4\u76f2\u539f\u56e0\u3002<\/p>\n

AMD\u7684\u75c5\u7406\u673a\u5236\u5e76\u6ca1\u6709\u5b8c\u5168\u9610\u660e\uff0c\u76ee\u524d\u666e\u904d\u8ba4\u53efVEGF\u8868\u8fbe\u589e\u52a0\u8bf1\u5bfc\u7684\u8840\u7ba1\u65b0\u751f\u662fnAMD\u53d1\u75c5\u7684\u4e3b\u8981\u539f\u56e0\uff0c\u8865\u4f53\u5f02\u5e38\u6d3b\u5316\u4ecb\u5bfc\u7684\u708e\u75c7\u53cd\u5e94\u4e5f\u88ab\u8ba4\u4e3a\u662fAMD\u53d1\u75c5\u7684\u91cd\u8981\u539f\u56e0\u3002\u773c\u7528\u6297VEGF\u836f\u7269\u5e26\u6765\u4e86\u663e\u8457\u7684\u89c6\u529b\u83b7\u76ca\u5e76\u6539\u53d8\u4e86nAMD\u7684\u75c5\u7a0b\uff0c\u4f46\u76ee\u524d\u9891\u7e41\u7684\u7ed9\u836f\uff08\u6bcf4\u5468\u62168\u5468\u4e00\u6b21\uff09\u7ed9\u60a3\u8005\u3001\u5bb6\u5ead\u548c\u793e\u4f1a\u5e26\u6765\u6c89\u91cd\u8d1f\u62c5\u3002\u6b64\u5916\uff0c\u6297VEGF\u836f\u7269\u6cbb\u7597\u7684\u89c6\u529b\u83b7\u76ca\u4f1a\u968f\u7740\u6cbb\u7597\u65f6\u95f4\u5ef6\u957f\u9010\u5e74\u4e22\u5931\u3002\u5728\u7ea62\/3\u7684\u968f\u8bbf7\u5e74\u4ee5\u4e0a\u7684\u60a3\u8005\u4e2d\uff0c\u6297VEGF\u6cbb\u7597\u5e26\u6765\u7684\u89c6\u529b\u83b7\u76ca\u4f1a\u5927\u5927\u4e27\u5931[4]<\/span><\/sup>\u3002\u9ec4\u6591\u840e\u7f29\u6216\u89c6\u7f51\u819c\u7ea4\u7ef4\u5316\u662f\u957f\u671f\u6297VEGF\u6cbb\u7597\u540e\u89c6\u529b\u83b7\u76ca\u4e22\u5931\u7684\u91cd\u8981\u539f\u56e0\u3002\u76ee\u524d\u9488\u5bf9nAMD\u7684\u836f\u7269\u5f00\u53d1\u4e3b\u8981\u5ef6\u957f\u7ed9\u836f\u95f4\u9694\uff0c\u9488\u5bf9\u9ec4\u6591\u840e\u7f29\u6216\u89c6\u7f51\u819c\u7ea4\u7ef4\u5316\u7684\u5728\u7814\u836f\u7269\u8f83\u5c11\u3002\u800c\u9488\u5bf9\u5e72\u6027\u5e74\u9f84\u76f8\u5173\u6027\u9ec4\u6591\u53d8\u6027\u6240\u81f4\u7684\u5730\u56fe\u6837\u840e\u7f29\uff0c\u5df2\u67092\u6b3e\u9776\u5411\u8865\u4f53\u7684\u836f\u7269\u4e8e2023\u5e74\u83b7\u7f8e\u56fdFDA\u6279\u51c6\u4e0a\u5e02[5,6]<\/span><\/sup>\u3002<\/p>\n

\u5173<\/b>\u4e8e<\/b>Efdamrofusp Alfa\uff08<\/b>IBI302<\/b>\uff09<\/b><\/p>\n

IBI302\u662f\u4fe1\u8fbe\u751f\u7269\u62e5\u6709\u5168\u7403\u77e5\u8bc6\u4ea7\u6743\u7684\u4e00\u79cd\u53cc\u7279\u5f02\u6027\u91cd\u7ec4\u5168\u4eba\u6e90\u878d\u5408\u86cb\u767d\u3002N\u7aef\u4e3aVEGF\u7ed3\u5408\u57df\uff0c\u80fd\u591f\u4e0eVEGF\u5bb6\u65cf\u7ed3\u5408\u963b\u65adVEGF\u4ecb\u5bfc\u7684\u4fe1\u53f7\u901a\u8def\uff0c\u6291\u5236\u8840\u7ba1\u5185\u76ae\u7ec6\u80de\u7684\u751f\u5b58\u3001\u589e\u6b96\uff0c\u4ece\u800c\u6291\u5236\u8840\u7ba1\u65b0\u751f\uff0c\u964d\u4f4e\u8840\u7ba1\u6e17\u900f\u6027\uff0c\u51cf\u5c11\u8840\u7ba1\u6e17\u6f0f\uff1bC\u7aef\u4e3a\u8865\u4f53\u7ed3\u5408\u57df\uff0c\u80fd\u591f\u901a\u8fc7\u7279\u5f02\u6027\u7ed3\u5408C3b\u548cC4b\uff0c\u6291\u5236\u8865\u4f53\u7ecf\u5178\u9014\u5f84\u548c\u65c1\u8def\u9014\u7ecf\u7684\u6fc0\u6d3b\uff0c\u51cf\u8f7b\u8865\u4f53\u6d3b\u5316\u4ecb\u5bfc\u7684\u708e\u75c7\u53cd\u5e94\u3002IBI302\u6f5c\u5728\u901a\u8fc7\u540c\u65f6\u6291\u5236VEGF\u4ecb\u5bfc\u7684\u65b0\u751f\u8840\u7ba1\u751f\u6210\u548c\u8865\u4f53\u6d3b\u5316\u901a\u8def\uff0c\u53d1\u6325\u6cbb\u7597\u4f5c\u7528\u3002<\/p>\n

\u5173\u4e8e\u4fe1\u8fbe\u751f\u7269<\/b><\/p>\n

"\u59cb\u4e8e\u4fe1\uff0c\u8fbe\u4e8e\u884c"\uff0c\u5f00\u53d1\u51fa\u8001\u767e\u59d3\u7528\u5f97\u8d77\u7684\u9ad8\u8d28\u91cf\u751f\u7269\u836f\uff0c\u662f\u4fe1\u8fbe\u751f\u7269\u7684\u4f7f\u547d\u548c\u76ee\u6807\u3002\u4fe1\u8fbe\u751f\u7269\u6210\u7acb\u4e8e2011\u5e74\uff0c\u81f4\u529b\u4e8e\u5f00\u53d1\u3001\u751f\u4ea7\u548c\u9500\u552e\u80bf\u7624\u3001\u4ee3\u8c22\u53ca\u5fc3\u8840\u7ba1\u3001\u81ea\u8eab\u514d\u75ab\u3001\u773c\u79d1\u7b49\u91cd\u5927\u75be\u75c5\u9886\u57df\u7684\u521b\u65b0\u836f\u7269\u3002\u516c\u53f8\u5df2\u670910\u6b3e\u4ea7\u54c1\u83b7\u5f97\u6279\u51c6\u4e0a\u5e02\uff0c\u540c\u65f6\u8fd8\u67093\u4e2a\u54c1\u79cd\u5728NMPA\u5ba1\u8bc4\u4e2d\uff0c5\u4e2a\u65b0\u836f\u5206\u5b50\u8fdb\u5165III\u671f\u6216\u5173\u952e\u6027\u4e34\u5e8a\u7814\u7a76\uff0c\u53e6\u5916\u8fd8\u670918\u4e2a\u65b0\u836f\u54c1\u79cd\u5df2\u8fdb\u5165\u4e34\u5e8a\u7814\u7a76\u3002\u516c\u53f8\u4e0e\u6d77\u5185\u5916\u836f\u4f01\u6df1\u5165\u5408\u4f5c\u52a0\u901f\u836f\u7269\u521b\u65b0\uff0c\u4e0e\u793c\u6765\u3001\u7f57\u6c0f\u3001\u8d5b\u8bfa\u83f2\u3001Adimab\u3001Incyte\u548cMD Anderson\u764c\u75c7\u4e2d\u5fc3\u7b49\u56fd\u9645\u5408\u4f5c\u65b9\u8fbe\u621030\u591a\u9879\u6218\u7565\u5408\u4f5c\u3002<\/p>\n

\u4fe1\u8fbe\u751f\u7269\u5728\u4e0d\u65ad\u5f00\u53d1\u521b\u65b0\u836f\u7269\u3001\u8c0b\u6c42\u81ea\u8eab\u53d1\u5c55\u7684\u540c\u65f6\uff0c\u59cb\u7ec8\u5fc3\u6000\u79d1\u5b66\u5584\u5ff5\uff0c\u575a\u5b88"\u4ee5\u60a3\u8005\u4e3a\u4e2d\u5fc3"\uff0c\u5fc3\u7cfb\u60a3\u8005\u5e76\u5173\u6ce8\u60a3\u8005\u5bb6\u5ead\uff0c\u79ef\u6781\u5c65\u884c\u793e\u4f1a\u8d23\u4efb\u3002\u4fe1\u8fbe\u751f\u7269\u5e0c\u671b\u548c\u5927\u5bb6\u4e00\u8d77\u52aa\u529b\uff0c\u63d0\u9ad8\u4e2d\u56fd\u751f\u7269\u5236\u836f\u4ea7\u4e1a\u7684\u53d1\u5c55\u6c34\u5e73\uff0c\u4ee5\u6ee1\u8db3\u767e\u59d3\u7528\u836f\u53ef\u53ca\u6027\u548c\u4eba\u6c11\u5bf9\u751f\u547d\u5065\u5eb7\u7f8e\u597d\u613f\u671b\u7684\u8ffd\u6c42\u3002<\/p>\n

\u8be6\u60c5\u8bf7\u8bbf\u95ee\u516c\u53f8\u7f51\u7ad9\uff1awww.innoventbio.com\u6216\u516c\u53f8\u9886\u82f1\u8d26\u53f7www.linkedin.com\/company\/innovent-biologics\/\u3002<\/p>\n

\u58f0\u660e\uff1a\u4fe1\u8fbe\u4e0d\u63a8\u8350\u4efb\u4f55\u672a\u83b7\u6279\u7684\u836f\u54c1<\/i>\/\u9002\u5e94\u75c7\u4f7f\u7528\u3002<\/i><\/p>\n

\u524d\u77bb\u6027\u58f0\u660e<\/b><\/p>\n

\u672c\u65b0\u95fb\u7a3f\u6240\u53d1\u5e03\u7684\u4fe1\u606f\u4e2d\u53ef\u80fd\u4f1a\u5305\u542b\u67d0\u4e9b\u524d\u77bb\u6027\u8868\u8ff0\u3002\u8fd9\u4e9b\u8868\u8ff0\u672c\u8d28\u4e0a\u5177\u6709\u76f8\u5f53\u98ce\u9669\u548c\u4e0d\u786e\u5b9a\u6027\u3002\u5728\u4f7f\u7528"\u9884\u671f"\u3001"\u76f8\u4fe1"\u3001"\u9884\u6d4b"\u3001"\u671f\u671b"\u3001"\u6253\u7b97"\u53ca\u5176\u4ed6\u7c7b\u4f3c\u8bcd\u8bed\u8fdb\u884c\u8868\u8ff0\u65f6\uff0c\u51e1\u4e0e\u672c\u516c\u53f8\u6709\u5173\u7684\uff0c\u76ee\u7684\u5747\u662f\u8981\u6307\u660e\u5176\u5c5e\u524d\u77bb\u6027\u8868\u8ff0\u3002\u672c\u516c\u53f8\u5e76\u65e0\u4e49\u52a1\u4e0d\u65ad\u5730\u66f4\u65b0\u8fd9\u4e9b\u9884\u6d4b\u6027\u9648\u8ff0\u3002<\/p>\n

\u8fd9\u4e9b\u524d\u77bb\u6027\u8868\u8ff0\u4e43\u57fa\u4e8e\u672c\u516c\u53f8\u7ba1\u7406\u5c42\u5728\u505a\u51fa\u8868\u8ff0\u65f6\u5bf9\u672a\u6765\u4e8b\u52a1\u7684\u73b0\u6709\u770b\u6cd5\u3001\u5047\u8bbe\u3001\u671f\u671b\u3001\u4f30\u8ba1\u3001\u9884\u6d4b\u548c\u7406\u89e3\u3002\u8fd9\u4e9b\u8868\u8ff0\u5e76\u975e\u5bf9\u672a\u6765\u53d1\u5c55\u7684\u4fdd\u8bc1\uff0c\u4f1a\u53d7\u5230\u98ce\u9669\u3001\u4e0d\u786e\u6027\u53ca\u5176\u4ed6\u56e0\u7d20\u7684\u5f71\u54cd\uff0c\u6709\u4e9b\u4e43\u8d85\u51fa\u672c\u516c\u53f8\u7684\u63a7\u5236\u8303\u56f4\uff0c\u96be\u4ee5\u9884\u8ba1\u3002\u56e0\u6b64\uff0c\u53d7\u6211\u4eec\u7684\u4e1a\u52a1\u3001\u7ade\u4e89\u73af\u5883\u3001\u653f\u6cbb\u3001\u7ecf\u6d4e\u3001\u6cd5\u5f8b\u548c\u793e\u4f1a\u60c5\u51b5\u7684\u672a\u6765\u53d8\u5316\u53ca\u53d1\u5c55\u7684\u5f71\u54cd\uff0c\u5b9e\u9645\u7ed3\u679c\u53ef\u80fd\u4f1a\u4e0e\u524d\u77bb\u6027\u8868\u8ff0\u6240\u542b\u8d44\u6599\u6709\u8f83\u5927\u5dee\u522b\u3002<\/p>\n

\u53c2\u8003\u6587\u732e\uff1a<\/p>\n

\n\n\n\n
\n

[1]   https:\/\/investor.regeneron.com\/static-files\/e3307e7d-d495-438c-b8bb-c62cdacdb375<\/a><\/span><\/p>\n

[2]   Heier, Jeffrey S et al. "Efficacy, durability, and safety of intravitreal faricimab up to every 16 weeks for neovascular age-related macular degeneration (TENAYA and LUCERNE): two randomised, double-masked, phase 3, non-inferiority trials." Lancet (London, England) vol. 399,10326 (2022): 729-740.<\/span><\/p>\n

[3]   Sassa Y, Hata Y. Antiangiogenic drugs in the management of ocular diseases: Focus on antivascular endothelial growth factor. Clinical Ophthalmology (Auckland, N.Z.). 2010;4:275-283.<\/span><\/p>\n

[4]   Rofagha S, Bhisitkul RB, Boyer DS, Sadda SR, Zhang K, SEVEN-UP Study Group. Seven-year outcomes in ranibizumab-treated patients in ANCHOR, MARINA, and HORIZON: a multicenter cohort study (SEVEN-UP). Ophthalmology. 2013;120(11):2292-2299. doi:10.1016\/j.ophtha.2013.03.046.<\/span><\/p>\n

[5]   FDA. SYFOVRE(pegcetacoplan injection). 2023.<\/span><\/p>\n

[6]   FDA. IZERVAY (avacincaptad pegol intravitreal solution).2023.<\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table><\/div>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

\u7f8e\u56fd\u7f57\u514b\u7ef4\u5c14\u548c\u4e2d\u56fd\u82cf\u5dde2024\u5e743\u670819\u65e5 \/\u7f8e\u901a\u793e\/ — \u4fe1\u8fbe\u751f\u7269\u5236\u836f\u96c6\u56e2\uff08\u9999\u6e2f\u8054\u4ea4\u6240\u80a1\u7968\u4ee3\u7801\uff1a01801\uff09\uff0c\u4e00\u5bb6\u81f4\u529b\u4e8e\u7814\u53d1\u3001\u751f\u4ea7\u548c\u9500\u552e\u80bf\u7624\u3001\u81ea\u8eab\u514d\u75ab\u3001\u4ee3\u8c22\u53ca\u5fc3\u8840\u7ba1\u3001\u773c\u79d1\u7b49\u91cd\u5927\u75be\u75c5\u9886\u57df\u521b\u65b0\u836f\u7269\u7684\u751f\u7269\u5236\u836f\u516c\u53f8\uff0c\u4eca\u65e5\u5ba3\u5e03\u5176\u7814\u53d1\u7684\u91cd\u7ec4\u4eba\u8840\u7ba1\u5185\u76ae\u751f\u957f\u56e0\u5b50\u53d7\u4f53\uff08VEGFR\uff09-\u6297\u4f53-\u4eba\u8865\u4f53\u53d7\u4f531 (CR1) \u878d\u5408\u86cb\u767dEfdamrofusp alfa\u6ce8\u5c04\u6db2\uff08\u7814\u53d1\u4ee3\u53f7\uff1aIBI302\uff09\u5728\u4e2d\u56fd\u65b0\u751f\u8840\u7ba1\u6027\u5e74\u9f84\u76f8\u5173\u6027\u9ec4\u6591\u53d8\u6027\uff08neovascular age-related macular degeneration, nAMD\uff09\u53d7\u8bd5\u8005\u4e2d\u5f00\u5c55\u7684\u7b2c\u4e8c\u9879IBI302 (\u9ad8\u5242\u91cf)\u7684II\u671f\u4e34\u5e8a\u7814\u7a76\u8fbe\u5230\u4e3b\u8981\u7ec8\u70b9\u3002 \u5df2\u5f00\u5c55\u7684\u5171\u5165\u7ec4\u8d85360\u4f8b\u53d7\u8bd5\u8005\u7684\u4e24\u9879II\u671f\u4e34\u5e8a\u7814\u7a76\u7ed3\u679c\u63d0\u793a\uff0c\u76f8\u8f83\u963f\u67cf\u897f\u666e\uff0cIBI302\u53ef\u5728\u957f\u95f4\u9694\u7ed9\u836f\uff083\u4e2a\u6708\u53ca\u4ee5\u4e0a\uff09\u4e0b\u5e26\u6765\u7a33\u5b9a\u7684\u89c6\u529b\u83b7\u76ca\u548c\u89e3\u5256\u5b66\u7597\u6548\u6539\u5584\uff0c\u5e76\u89c2\u5bdf\u5230\u5bf9\u9ec4\u6591\u840e\u7f29\u7684\u6f5c\u5728\u6539\u5584\u4f5c\u7528\u3002\u6b64\u524d\uff0c\u4fe1\u8fbe\u751f\u7269\u5df2\u4e8e2023\u5e7410\u6708\u542f\u52a8\u4e86IBI302 8mg\u7528\u4e8e\u6cbb\u7597nAMD\u7684III\u671f\u4e34\u5e8a\u7814\u7a76\uff08STAR\uff09\u3002 \u672c\u6b21\u8fbe\u5230\u7ec8\u70b9\u7684\u662f\u4e00\u9879\u5728nAMD\u53d7\u8bd5\u8005\u4e2d\u8bc4\u4f30\u957f\u95f4\u9694\u73bb\u7483\u4f53\u8154\u6ce8\u5c04IBI302\u7684\u7597\u6548\u548c\u5b89\u5168\u6027\u7684\u968f\u673a\u3001\u53cc\u76f2\u3001\u6d3b\u6027\u5bf9\u7167\u7684II\u671f\u4e34\u5e8a\u7814\u7a76\uff08NCT05403749\uff09\u3002132\u4f8b\u53d7\u8bd5\u8005\u4ee51:1:1\u968f\u673a\u5206\u914d\u81f3IBI302 6.4 mg\u7ec4\u3001IBI302 8.0mg\u7ec4\u3001\u963f\u67cf\u897f\u666e 2.0mg\u7ec4\u3002IBI302 6.4 mg\u7ec4\u548c8.0 mg\u7ec4\u5728\u8d1f\u8377\u6cbb\u7597\u9636\u6bb5\u540e\u6839\u636e\u6cbb\u7597\u53cd\u5e94\u8c03\u6574\u81f3\u6bcf8\u5468\uff08Q8W\uff09\u6216\u6bcf12\u5468\uff08Q12W\uff09\u7ed9\u836f1\u6b21\u3002\u963f\u67cf\u897f\u666e2.0mg\u7ec4\u8d1f\u8377\u6cbb\u7597\u540e\uff0c\u6309\u7167Q8W\u6cbb\u7597\u3002\u8be5\u8bd5\u9a8c\u7684\u4e3b\u8981\u7ec8\u70b9\u6307\u6807\u4e3a\u5728\u7b2c40\u5468\u65f6\uff0c\u7814\u7a76\u773c\u6700\u4f73\u77eb\u6b63\u89c6\u529b\uff08best corrected visual acuity, BCVA\uff09\u8bc4\u5206\u8f83\u57fa\u7ebf\u7684\u6539\u53d8\u3002\u7814\u7a76\u603b\u5468\u671f\u4e3a52\u5468\u3002 \u7814\u7a76\u7ed3\u679c\u663e\u793a\u987a\u5229\u8fbe\u6210\u4e3b\u8981\u7ec8\u70b9\uff1a\u7b2c40\u5468\u65f6\uff0cIBI302 6.4 mg\u7ec4\u4e0e8.0 mg\u7ec4\u7814\u7a76\u773cBCVA\u8f83\u57fa\u7ebf\u6539\u5584\u503c\u975e\u52a3\u6548\u4e8e\u963f\u67cf\u897f\u666e2.0 mg\u7ec4\u3002\u7b2c40\u5468\u65f6\uff0cIBI302 6.4 mg\u7ec4\u3001IBI302 8.0 mg\u7ec4\u3001\u963f\u67cf\u897f\u666e 2.0 mg\u7ec4BCVA\u8f83\u57fa\u7ebf\u63d0\u9ad8\u7684\u5747\u503c\u5206\u522b\u4e3a10.5\u300111.0\u30019.8\u4e2aETDRS\u5b57\u6bcd\u6570\u3002 \u5728\u89e3\u5256\u5b66\u7597\u6548\u7ec8\u70b9\u4e0a\uff0c\u7b2c40\u5468\u65f6\uff0cIBI302 6.4 mg\u7ec4\u4e0e8.0 mg\u7ec4\u4e2d\u592e\u89c6\u7f51\u819c\u539a\u5ea6\uff08central subfield thickness, CST\uff09\u8f83\u57fa\u7ebf\u6539\u5584\u7684\u5747\u503c\u5206\u522b\u4e3a-163.19 \u03bcm\u3001-184.46 \u03bcm\uff0c\u963f\u67cf\u897f\u666e 2.0 mg\u7ec4\u4e3a-108.23 \u03bcm\u3002 \u6b64\u5916\uff0c6.4mg IBI302\u7ec4\u4e0e8.0mg IBI302\u7ec4\u7ef4\u6301Q12W\u7ed9\u836f\u95f4\u9694\u7684\u53d7\u8bd5\u8005\u6bd4\u4f8b\u5206\u522b\u4e3a81%\u300188%\u3002\u95f4\u63a5\u6bd4\u8f83\uff0c\u4e0e\u963f\u67cf\u897f\u666e 8.0 mg\uff08PULSAR\u8bd5\u9a8c\u4e3a83%\uff09[1]\u548c\u6cd5\u745e\u897f\u5355\u6297\uff08TENAYA\u8bd5\u9a8c&LUCERNE\u8bd5\u9a8c\u5206\u522b\u4e3a79.7%\uff0c77.8%\uff09[2]\u7684Q12W\u53ca\u4ee5\u4e0a\u95f4\u9694\u7684\u53d7\u8bd5\u8005\u6bd4\u4f8b\u76f8\u4f3c\u3002\u57fa\u4e8eII\u671f\u4e2d\u4f18\u5f02\u7684\u957f\u95f4\u9694\u7ed9\u836f\u6548\u679c\uff0c\u5728III\u671f\u4e34\u5e8a\u7814\u7a76\uff08STAR\uff09\u589e\u52a0\u4e86IBI302\u7ef4\u6301Q16W\u7ed9\u836f\u95f4\u9694\u7684\u6cbb\u7597\u961f\u5217\u3002 \u7814\u7a76\u671f\u95f4IBI302\u6574\u4f53\u5b89\u5168\u6027\u826f\u597d\uff0c\u4e0e\u963f\u67cf\u897f\u666e2.0… Read More<\/a><\/p>\n","protected":false},"author":556,"featured_media":0,"comment_status":"close","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1965],"tags":[],"class_list":["post-108241","post","type-post","status-publish","format-standard","hentry","category-partnerships"],"amp_enabled":true,"_links":{"self":[{"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/posts\/108241","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/users\/556"}],"replies":[{"embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/comments?post=108241"}],"version-history":[{"count":1,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/posts\/108241\/revisions"}],"predecessor-version":[{"id":108242,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/posts\/108241\/revisions\/108242"}],"wp:attachment":[{"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/media?parent=108241"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/categories?post=108241"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/tags?post=108241"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}