{"id":107998,"date":"2024-03-15T14:32:00","date_gmt":"2024-03-15T07:32:00","guid":{"rendered":"https:\/\/www.xinwengao.com\/cn\/pr\/20240315143200107998"},"modified":"2024-03-16T00:33:13","modified_gmt":"2024-03-15T16:33:13","slug":"%e5%8b%83%e6%9e%97%e6%a0%bc%e6%ae%b7%e6%a0%bc%e7%bf%b0%e6%90%ba%e6%89%8bsosei-heptares%e5%bc%80%e5%8f%91%e9%92%88%e5%af%b9%e7%b2%be%e7%a5%9e%e5%88%86%e8%a3%82%e7%97%87%e6%89%80%e6%9c%89%e7%97%87","status":"publish","type":"post","link":"https:\/\/www.xinwengao.com\/cn\/pr\/20240315143200107998","title":{"rendered":"\u52c3\u6797\u683c\u6bb7\u683c\u7ff0\u643a\u624bSosei Heptares\u5f00\u53d1\u9488\u5bf9\u7cbe\u795e\u5206\u88c2\u75c7\u6240\u6709\u75c7\u72b6\u7684\u540c\u7c7b\u9996\u521b\u7597\u6cd5"},"content":{"rendered":"<p><p><span class=\"legendSpanClass\">\u5fb7\u56fd\u6bb7\u683c\u7ff0\u3001\u65e5\u672c\u4e1c\u4eac\u548c\u82f1\u56fd\u5251\u6865<\/span><span class=\"legendSpanClass\">2024\u5e743\u670815\u65e5<\/span> \/\u7f8e\u901a\u793e\/ &#8212; \u8fd1\u65e5\uff0c\u52c3\u6797\u683c\u6bb7\u683c\u7ff0\u548cSosei\u96c6\u56e2\uff08&quot;Sosei Heptares&quot;\uff1bTSE\uff1a4565\uff09\u5ba3\u5e03\u53cc\u65b9\u5df2\u7ecf\u8fbe\u6210\u4e00\u9879\u5168\u7403\u5408\u4f5c\u548c\u72ec\u5bb6\u9009\u62e9\u6743\u8bb8\u53ef\u534f\u8bae\u3002\u53cc\u65b9\u5408\u4f5c\u7684\u6838\u5fc3\u662f\u5f00\u53d1\u548c\u5546\u4e1a\u5316Sosei Heptares\u7684\u540c\u7c7b\u9996\u521bGPR52\u6fc0\u52a8\u5242\uff0cGPR52\u6fc0\u52a8\u5242\u662f\u4e00\u79cd\u65b0\u578bG\u86cb\u767d\u5076\u8054\u53d7\u4f53\uff08GPCR\uff09\u9776\u70b9\uff0c\u65e8\u5728\u540c\u65f6\u89e3\u51b3\u7cbe\u795e\u5206\u88c2\u75c7\u7684\u9633\u6027\u3001\u9634\u6027\u548c\u8ba4\u77e5\u75c7\u72b6\u6765\u6539\u5584\u60a3\u8005\u7684\u9884\u540e\u3002<sup>[1]<sup>,<\/sup>[2]<sup>,<\/sup>[3]<\/sup><\/p>\n<p>\u7cbe\u795e\u5206\u88c2\u75c7\u662f\u4e00\u79cd\u4e25\u91cd\u7684\u75be\u75c5\uff0c\u5168\u7403\u5927\u7ea6\u6bcf100\u4eba\u4e2d\u5c31\u67091\u4eba\u53d7\u5230\u5f71\u54cd<sup>[4]<\/sup>\u3002\u5b83\u7684\u7279\u5f81\u662f\u4e09\u7c7b\u75c7\u72b6\u7fa4<sup>[5]<sup>,<\/sup>[6]<\/sup>\uff1a&nbsp;<\/p>\n<ul type=\"disc\">\n<li>\u9633\u6027\u75c7\u72b6\u2014\u2014\u5982\u7cbe\u795e\u75c5\u3001\u5984\u60f3\u548c\u5e7b\u89c9<\/li>\n<li>\u9634\u6027\u75c7\u72b6\u2014\u2014\u5982\u793e\u4ea4\u5c01\u95ed\u548c\u51b7\u6f20<\/li>\n<li>\u8ba4\u77e5\u75c7\u72b6\u2014\u2014\u5982\u6ce8\u610f\u529b\u3001\u8ba1\u5212\u548c\u8bb0\u5fc6\u7f3a\u9677<\/li>\n<\/ul>\n<p>\u8fd9\u4e9b\u75c7\u72b6\u5bf9\u4eba\u4eec\u65e5\u5e38\u751f\u6d3b\u7684\u80fd\u529b\u4ea7\u751f\u4e86\u91cd\u5927\u5f71\u54cd\uff0c\u800c\u4e14\u5bf9\u7167\u987e\u8005\u548c\u6574\u4e2a\u793e\u4f1a\u4ea7\u751f\u5de8\u5927\u7684\u8d1f\u62c5\uff0c\u5c24\u5176\u662f\u56e0\u4e3a\u8be5\u75be\u75c5\u7684\u53d1\u75c5\u5e74\u9f84\u901a\u5e38\u572820\u591a\u5c81<sup>[7]<\/sup>\u3002\u867d\u7136\u9633\u6027\u75c7\u72b6\u53ef\u4ee5\u7528\u6297\u7cbe\u795e\u75c5\u836f\u7269\u7a33\u5b9a\uff0c\u4f46\u662f\u5176\u4e2d\u4e00\u4e9b\u836f\u7269\u53ef\u80fd\u6709\u526f\u4f5c\u7528\uff0c\u76ee\u524d\u8fd8\u6ca1\u6709\u83b7\u6279\u7684\u836f\u7269\u53ef\u7528\u4e8e\u9634\u6027\u6216\u8ba4\u77e5\u75c7\u72b6\u3002<\/p>\n<p>\u9488\u5bf9GPR52\u5f00\u53d1\u7684\u65b0\u578b\u7cbe\u795e\u5206\u88c2\u75c7\u6cbb\u7597\u65b9\u6cd5\u6709\u6f5c\u529b\u89e3\u51b3\u7cbe\u795e\u5206\u88c2\u75c7\u7684\u8fd9\u4e09\u4e2a\u65b9\u9762<sup>[1]<\/sup><sup>,[<\/sup><sup>2]<\/sup>\uff0c\u63d0\u4f9b\u4e00\u79cd\u5168\u65b0\u7684\u7cbe\u51c6\u6cbb\u7597\u65b9\u6cd5\u3002\u8fd9\u57fa\u4e8e\u8be5\u53d7\u4f53\u4f4d\u4e8e\u5927\u8111\u7684\u4e24\u4e2a\u533a\u57df\uff0c\u8fd9\u4e24\u4e2a\u533a\u57df\u5206\u522b\u9a71\u52a8\u9633\u6027\uff08\u7eb9\u72b6\u4f53\uff09\u548c\u9634\u6027\u53ca\u8ba4\u77e5\u75c7\u72b6\uff08\u524d\u989d\u53f6\u76ae\u5c42\uff09\u3002GPR52\u6fc0\u52a8\u4f5c\u7528\u53ef\u4ee5\u5e73\u9759\u7eb9\u72b6\u4f53\u540c\u65f6\u589e\u5f3a\u989d\u53f6\u76ae\u5c42\u529f\u80fd\uff0c\u4ece\u800c\u5b9e\u73b0\u8fdb\u4e00\u6b65\u7684\u7cbe\u51c6\u6cbb\u7597<sup>[8]<\/sup>\u3002<\/p>\n<p>\u52c3\u6797\u683c\u6bb7\u683c\u7ff0\u5168\u7403\u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf\u53d1\u73b0\u7814\u7a76\u8d1f\u8d23\u4ebaHugh Marston\u8868\u793a\uff1a&quot;\u6211\u4eec\u975e\u5e38\u9ad8\u5174\u80fd\u4e0eSosei Heptares\u516c\u53f8\u5c31\u8fd9\u4e00\u65b0\u578b\u7597\u6cd5\u5efa\u7acb\u5408\u4f5c\uff0c\u4ee5\u89e3\u51b3\u7cbe\u795e\u5206\u88c2\u75c7\u60a3\u8005\u5de8\u5927\u672a\u6ee1\u8db3\u7684\u9700\u6c42\u3002\u6b64\u9879\u5408\u4f5c\u4e0e\u6211\u4eec\u5176\u4ed6\u7684\u5f00\u53d1\u8ba1\u5212\u9ad8\u5ea6\u4e92\u8865\uff0c\u65e8\u5728\u4e3a\u7cbe\u795e\u5065\u5eb7\u75be\u75c5\u5e26\u6765\u65b0\u7684\u7cbe\u51c6\u533b\u5b66\u65b9\u6cd5\uff0c\u6211\u4eec\u5e0c\u671b\u901a\u8fc7\u8fd9\u4e00\u7597\u6cd5\u6539\u53d8\u7cbe\u795e\u5206\u88c2\u75c7\u60a3\u8005\u7684\u751f\u6d3b\u3002&quot;<\/p>\n<p>Heptares Therapeutics\u603b\u88c1\u3001Sosei Heptares\u82f1\u56fd\u7814\u53d1\u8d1f\u8d23\u4ebaMatt Barnes\u8868\u793a\uff1a&quot;\u6b64\u6b21\u5408\u4f5c\u7a81\u663e\u4e86GPR52\u5728\u4e34\u5e8a\u524d\u7814\u7a76\u4e2d\u4f5c\u4e3a\u4e00\u79cd\u65b0\u578b\u7684\u3001\u540c\u7c7b\u9996\u521b\u9776\u70b9\u5728\u6cbb\u7597\u7cbe\u795e\u5206\u88c2\u75c7\u548c\u76f8\u5173\u795e\u7ecf\u75be\u75c5\u7597\u6cd5\u4e0a\u6240\u5c55\u73b0\u7684\u5de8\u5927\u6f5c\u529b\u3002\u6211\u4eec\u5f88\u9ad8\u5174\u80fd\u4e0e\u52c3\u6797\u683c\u6bb7\u683c\u7ff0\u5408\u4f5c\uff0c\u5e76\u5229\u7528\u5176\u5728\u795e\u7ecf\u75be\u75c5\u7814\u7a76\u548c\u521b\u65b0\u65b9\u9762\u7684\u9886\u5148\u4e13\u957f\u3002\u6211\u4eec\u5c06\u5171\u540c\u4e13\u6ce8\u4e8e\u52a0\u901f\u8fd9\u4e2a\u9ad8\u5ea6\u521b\u65b0\u9879\u76ee\u7684\u5f00\u53d1\uff0c\u8be5\u9879\u76ee\u76ee\u524d\u6b63\u5728\u8fdb\u884cI\u671f\u4e34\u5e8a\u7814\u7a76\uff0c\u4e3b\u8981\u9762\u5411\u6709\u9700\u8981\u7684\u60a3\u8005\u3002&quot;<\/p>\n<p><b>\u5173\u4e8e\u5408\u4f5c\u534f\u8bae<\/b>&nbsp;<\/p>\n<p>\u6839\u636e\u534f\u8bae\uff0cSosei Heptares \u5c06\u4ece\u52c3\u6797\u683c\u6bb7\u683c\u7ff0\u83b7\u5f97&nbsp;2500 \u4e07\u6b27\u5143\u7684\u9884\u4ed8\u6b3e\uff0c\u5e76\u6709\u8d44\u683c\u83b7\u5f97&nbsp;6000 \u4e07\u6b27\u5143\u7684\u9009\u62e9\u6743\u884c\u4f7f\u4ed8\u6b3e\uff0c\u4ee5\u53ca\u8fdb\u4e00\u6b65\u5f00\u53d1\u3001\u76d1\u7ba1\u548c\u5546\u4e1a\u5316\u91cc\u7a0b\u7891\u4ed8\u6b3e\uff0c\u603b\u8ba1\u9ad8\u8fbe&nbsp;6.7 \u4ebf\u6b27\u5143\uff0c\u4ee5\u53ca\u4e34\u5e8a\u9636\u6bb5\u8d44\u4ea7\u5728\u52c3\u6797\u683c\u6bb7\u683c\u7ff0\u672a\u6765\u4ea7\u54c1\u9500\u552e\u4e2d\u7684\u5206\u7ea7\u9500\u552e\u5206\u6210\u3002<\/p>\n<p>\u6839\u636e\u534f\u8bae\u6761\u6b3e\uff0c\u52c3\u6797\u683c\u6bb7\u683c\u7ff0\u62e5\u6709\u72ec\u5bb6\u9009\u62e9\u6743\uff0c\u5728\u5b8c\u6210 Sosei Heptares \u516c\u53f8\u9488\u5bf9HTL0048149\uff08\u4e00\u79cd\u540c\u7c7b\u9996\u521b GPR52 \u6fc0\u52a8\u5242\uff09\u6b63\u5728\u8fdb\u884c\u7684 1 \u671f\u8bd5\u9a8c\u3001\u968f\u540e\u7684 <span class=\"xn-money\">1b<\/span> \u671f\u8bd5\u9a8c\u4ee5\u53ca\u8fdb\u4e00\u6b65 2 \u671f\u8bd5\u9a8c\u7533\u8bf7\u540e\uff0c\u6709\u6743\u83b7\u53d6 Sosei Heptares \u7684 GPR52 \u6fc0\u52a8\u5242\u7684\u72ec\u5bb6\u8bb8\u53ef\u3002Sosei Heptares \u5c06\u4fdd\u7559\u5bf9\u8fd9\u4e9b\u8bd5\u9a8c\u7684\u63a7\u5236\u6743\uff0c\u5e76\u8d5e\u52a9\u8fd9\u4e9b\u8bd5\u9a8c\uff0c\u76f4\u5230\u9884\u8ba1\u4e8e 2025 \u5e74\u884c\u4f7f\u9009\u62e9\u6743\u4e3a\u6b62\u3002\u83b7\u5f97\u8bb8\u53ef\u7684\u4ea7\u54c1\u7ec4\u5408\u5c06\u5305\u62ec HTL0048149 \u4ee5\u53ca Sosei Heptares \u5229\u7528\u5176 StaR<sup>&reg;<\/sup> \u6280\u672f\u548c\u57fa\u4e8e\u7ed3\u6784\u7684\u836f\u7269\u8bbe\u8ba1 (SBDD) \u5e73\u53f0\u8bbe\u8ba1\u7684\u591a\u4e2a\u5dee\u5f02\u5316\u5907\u7528\u5316\u5408\u7269\u3002<\/p>\n<p><b>\u5173\u4e8e<\/b><b>GPR52 and HTL0048149<br \/><\/b><\/p>\n<p>GPR52\u662f\u4e00\u79cd\u5728\u5927\u8111\u4e2d\u9ad8\u5ea6\u8868\u8fbe\u7684\u5b64\u513fG\u86cb\u767d\u5076\u8054\u53d7\u4f53\uff08GPCR\uff09\uff0c\u5c24\u5176\u5728\u7eb9\u72b6\u4f53\u548c\u524d\u989d\u76ae\u8d28\u4e2d\uff0c\u5b83\u662f\u4e00\u79cd\u6f5c\u5728\u7684\u65b0\u5174\u6cbb\u7597\u9776\u70b9\uff0c\u7528\u4e8e\u6cbb\u7597\u4e00\u7cfb\u5217\u795e\u7ecf\u548c\u795e\u7ecf\u7cbe\u795e\u75be\u75c5<sup>[9]<\/sup>\u3002<\/p>\n<p>Sosei Heptares\u5df2\u7ecf\u5f00\u53d1\u4e86\u4e00\u7cfb\u5217\u9009\u62e9\u6027GPR52\u6fc0\u52a8\u5242\u548c\u8c03\u8282\u5242\uff0c\u5229\u7528\u5176StaR<sup>&reg;<\/sup>\u6280\u672fSBDD\u5e73\u53f0\u7684\u4e13\u6709\u6d1e\u5bdf\uff0c\u5176\u4e2d\u6700\u5148\u8fdb\u7684\uff08HTL0048149\uff09\u5df2\u57282023\u5e74\u8fdb\u5165\u4e86\u9996\u6b21\u4eba\u4f53\u4e34\u5e8a\u8bd5\u9a8c<sup>[10]<\/sup>\u3002<\/p>\n<p>HTL&#8217;149\u88ab\u8bbe\u8ba1\u4e3a\u4e00\u79cd\u6bcf\u65e5\u4e00\u6b21\u7684\u53e3\u670d\u836f\u7269\uff0c\u9009\u62e9\u6027\u5730\u9776\u5411GPR52\uff0c\u5177\u6709\u6297\u7cbe\u795e\u75c5\u548c\u4fc3\u8fdb\u8ba4\u77e5\u7684\u7279\u6027\u3002\u72ec\u7279\u7684\u662f\uff0cHTL&#8217;149\u65e8\u5728\u6cbb\u7597\u4e0e\u7cbe\u795e\u5206\u88c2\u75c7\u76f8\u5173\u7684\u9633\u6027\u75c7\u72b6\uff08\u4f8b\u5982\u7cbe\u795e\u75c5\uff0c\u5984\u60f3\uff0c\u5e7b\u89c9\uff09\uff0c\u9634\u6027\u75c7\u72b6\uff08\u4f8b\u5982\u793e\u4ea4\u9000\u7f29\u548c\u51b7\u6f20\uff09\u548c\u8ba4\u77e5\u969c\u788d\uff08\u4f8b\u5982\u6ce8\u610f\u529b\u3001\u8ba1\u5212\u548c\u8bb0\u5fc6\u7f3a\u9677\uff09\uff0c\u5e76\u5c3d\u91cf\u51cf\u5c11\u4e0e\u4e00\u4e9b\u73b0\u6709\u6297\u7cbe\u795e\u75c5\u836f\u7269\u76f8\u5173\u7684\u4e0d\u826f\u53cd\u5e94<sup>[9],[11]<sup>,<\/sup>[12]<sup>,<\/sup>[13]<\/sup>\u3002<\/p>\n<p>\u901a\u8fc7\u8fd9\u79cd\u65b0\u7684\u4f5c\u7528\u673a\u5236\uff0cHTL&#8217;149\u65e8\u5728\u89e3\u51b3\u5927\u91cf\u4e0d\u5bf9\u73b0\u6709\u6cbb\u7597\u65b9\u6cd5\u4ea7\u751f\u53cd\u5e94\u6216\u65e0\u6cd5\u5fcd\u53d7\u6297\u7cbe\u795e\u75c5\u836f\u7269\u526f\u4f5c\u7528\u7684\u7cbe\u795e\u5206\u88c2\u75c7\u60a3\u8005\uff0c\u8fd9\u4e9b\u56e0\u7d20\u90fd\u53ef\u80fd\u5bfc\u81f4\u7cbe\u795e\u75c5\u60a3\u8005\u7684\u6cbb\u7597\u4f9d\u4ece\u6027\u4e0d\u8db3\u3002\u6b64\u5916\uff0c\u5f53\u524d\u7684\u6297\u7cbe\u795e\u75c5\u836f\u7269\u65e0\u6cd5\u6709\u6548\u6cbb\u7597\u75be\u75c5\u7684\u9634\u6027\u6216\u8ba4\u77e5\u75c7\u72b6\u3002<\/p>\n<p>HTL&#8217;149\u6b63\u5728\u8fdb\u884c\u4e00\u98791a\/b\u671f\u968f\u673a\u3001\u53cc\u76f2\u3001\u5b89\u6170\u5242\u5bf9\u7167\uff0c\u5355\u6b21\u548c\u591a\u6b21\u9012\u589e\u5242\u91cf\u7814\u7a76\uff0c\u4ee5\u8bc4\u4f30\u5176\u572818-55\u5c81\u7684\u5065\u5eb7\u5fd7\u613f\u8005\u4e2d\u7684\u5b89\u5168\u6027\u3001\u836f\u4ee3\u52a8\u529b\u5b66\u548c\u836f\u6548\u5b66\u3002\u8be5\u8bd5\u9a8c\u6b63\u5728\u82f1\u56fd\u8fdb\u884c\uff0c\u9884\u8ba1\u5c06\u57282025\u5e74\u83b7\u5f97\u521d\u6b65\u6570\u636e<sup>[9],[14]<\/sup>\u3002<\/p>\n<p><b>\u5173\u4e8e\u52c3\u6797\u683c\u6bb7\u683c\u7ff0<\/b><\/p>\n<p>\u52c3\u6797\u683c\u6bb7\u683c\u7ff0\u81f4\u529b\u4e8e\u7814\u7a76\u7a81\u7834\u6027\u7597\u6cd5\uff0c\u65e8\u5728\u53d8\u9769\u751f\u547d\uff0c\u5b88\u62a4\u4e16\u4e16\u4ee3\u4ee3\u7684\u5065\u5eb7\u3002\u4f5c\u4e3a\u4e00\u5bb6\u7814\u53d1\u9a71\u52a8\u7684\u5168\u7403\u9886\u5148\u751f\u7269\u5236\u836f\u4f01\u4e1a\uff0c\u516c\u53f8\u5728\u533b\u7597\u9700\u6c42\u9ad8\u5ea6\u672a\u5f97\u5230\u6ee1\u8db3\u7684\u9886\u57df\u901a\u8fc7\u521b\u65b0\u5c55\u73b0\u4ef7\u503c\u3002\u52c3\u6797\u683c\u6bb7\u683c\u7ff0\u81ea1885\u5e74\u6210\u7acb\u4ee5\u6765\u4e00\u76f4\u662f\u4e00\u5bb6\u72ec\u7acb\u7684\u5bb6\u65cf\u4f01\u4e1a\uff0c\u59cb\u7ec8\u7740\u773c\u957f\u8fdc\u4e0e\u53ef\u6301\u7eed\u53d1\u5c55\u3002\u5728\u4eba\u7528\u836f\u54c1\u3001\u52a8\u7269\u4fdd\u5065\u4e24\u5927\u4e1a\u52a1\u9886\u57df\uff0c\u5168\u7403\u6709\u8d85\u8fc75.3\u4e07\u540d\u5458\u5de5\u670d\u52a1\u903e130\u4e2a\u5730\u533a\u3002\u66f4\u591a\u8be6\u60c5\uff0c\u8bf7\u8bbf\u95ee\uff1a<a href=\"http:\/\/www.boehringer-ingelheim.com\/\" target=\"_blank\" rel=\"nofollow noopener\">www.boehringer-ingelheim.com<\/a><\/p>\n<p>\u52c3\u6797\u683c\u6bb7\u683c\u7ff0\u62e5\u6709\u521b\u65b0\u7684\u7cbe\u795e\u5065\u5eb7\u4ea7\u54c1\u7ba1\u7ebf\uff0c\u4e13\u6ce8\u4e8e\u7814\u53d1\u5177\u6709\u9ad8\u5ea6\u672a\u6ee1\u8db3\u60a3\u8005\u9700\u6c42\u7684\u7cbe\u51c6\u7cbe\u795e\u75c5\u6cbb\u7597\u65b9\u5f0f\u3002\u5173\u952e\u6027\u8bd5\u9a8c\u5305\u542b\u7814\u53d1\u7518\u6c28\u9178\u8f6c\u8fd0\u86cb\u767d\u7c7b\u578b-1\uff08GlyT1\uff09\u6291\u5236\u5242iclepertin\uff0c\u7528\u4e8e\u6cbb\u7597\u4e0e\u7cbe\u795e\u5206\u88c2\u75c7\u76f8\u5173\u7684\u8ba4\u77e5\u969c\u788d\uff08CIAS\uff09\uff08NCT04846868\uff0cNCT04846881\uff09\uff0c\u4ee5\u53ca\u4e00\u4e2a\u5904\u65b9\u6570\u5b57\u6cbb\u7597\u6cd5\uff08PDT\uff09CT-155\uff0c\u7528\u4e8e\u6cbb\u7597\u7cbe\u795e\u5206\u88c2\u75c7\u7684\u9634\u6027\u75c7\u72b6\uff08NCT05838625\uff09<sup>[15]<\/sup>\u3002<\/p>\n<p><b>\u5173\u4e8e<\/b><b>Sosei Heptares<\/b><\/p>\n<p>Sosei Heptares\u662f\u4e00\u5bb6\u5168\u9762\u6574\u5408\u7684\u751f\u7269\u5236\u836f\u516c\u53f8\uff0c\u57fa\u4e8e\u5176\u4e16\u754c\u7ea7\u7684\u79d1\u5b66\u7814\u7a76\uff0c\u4e3a\u5168\u7403\u60a3\u8005\u5e26\u6765\u6539\u53d8\u751f\u547d\u7684\u836f\u7269\u3002\u6211\u4eec\u7684\u613f\u666f\u662f\u6210\u4e3a\u4e00\u5bb6\u5728\u65e5\u672c\u7684\u5168\u7403\u751f\u7269\u5236\u836f\u516c\u53f8\u3002\u6211\u4eec\u5168\u7403\u4e1a\u52a1\u7ed3\u5408\u4e86\u6211\u4eec\u5728\u82f1\u56fd\u4e16\u754c\u9886\u5148\u7684GPCR\u9776\u5411StaR<sup>&reg;<\/sup>\u6280\u672f\uff0c\u8be5\u6280\u672f\u57fa\u4e8e\u7ed3\u6784\u836f\u7269\u8bbe\u8ba1\u548c\u65e9\u671f\u5f00\u53d1\u80fd\u529b\uff0c\u4ee5\u53ca\u5728\u65e5\u672c\u6781\u5177\u7ecf\u9a8c\u7684\u4e34\u5e8a\u5f00\u53d1\u548c\u5546\u4e1a\u8fd0\u8425\u80fd\u529b\u3002\u6211\u4eec\u5229\u7528\u8fd9\u4e9b\u80fd\u529b\u6765\u5f00\u53d1\u548c\u63a8\u8fdb\u5e7f\u6cdb\u800c\u6df1\u5165\u7684\u65b0\u836f\u7ba1\u7ebf\uff0c\u7ba1\u7ebf\u6db5\u76d6\u591a\u4e2a\u6cbb\u7597\u9886\u57df\uff0c\u5305\u62ec\u795e\u7ecf\u3001\u514d\u75ab\u3001\u80c3\u80a0\u75c5\u548c\u708e\u75c7\u6027\u75be\u75c5\u9886\u57df\u3002\u6211\u4eec\u5e0c\u671b\u53cc\u7ba1\u9f50\u4e0b\uff0c\u901a\u8fc7\u5185\u90e8\u7814\u53d1\u548c\u4e0e\u5168\u7403\u751f\u7269\u5236\u836f\u516c\u53f8\u548c\u65b0\u5174\u6280\u672f\u516c\u53f8\u5408\u4f5c\uff0c\u4e3a\u65e5\u672c\u548c\u5168\u7403\u7684\u60a3\u8005\u5f00\u53d1\u8fd9\u4e9b\u7597\u6cd5\u3002<\/p>\n<p>Sosei Heptares\u5728\u65e5\u672c\u4e1c\u4eac\u548c\u5927\u962a\u3001\u82f1\u56fd\u4f26\u6566\u548c\u5251\u6865\u3001\u745e\u58eb\u5df4\u585e\u5c14\u548c\u97e9\u56fd\u9996\u5c14\u7b49\u5173\u952e\u57ce\u5e02\u5747\u6709\u4e1a\u52a1\u8fd0\u8425\u6d3b\u52a8\u3002<\/p>\n<p>&quot;Sosei Heptares&quot;\u662fSosei\u96c6\u56e2\u516c\u53f8\u7684\u4f01\u4e1a\u54c1\u724c\u548c\u5546\u6807\uff0c\u8be5\u516c\u53f8\u5728\u4e1c\u4eac\u8bc1\u5238\u4ea4\u6613\u6240\u4e0a\u5e02\uff08\u80a1\u7968\u4ee3\u7801\uff1a4565\uff09\u3002Sosei\u3001Heptares\u3001\u4f01\u4e1a\u6807\u8bc6\u548cStaR<sup>&reg;<\/sup>\u5747\u4e3aSosei\u96c6\u56e2\u516c\u53f8\u7684\u5546\u6807\u3002<\/p>\n<p>\u5982\u9700\u4e86\u89e3\u66f4\u591a\u4fe1\u606f\u8bf7\u8bbf\u95ee\uff1a&nbsp;<a href=\"https:\/\/soseiheptares.com\/\" target=\"_blank\" rel=\"nofollow noopener\">https:\/\/soseiheptares.com\/<\/a><\/p>\n<p>LinkedIn: <a href=\"https:\/\/www.linkedin.com\/company\/soseiheptaresco\/\" target=\"_blank\" rel=\"nofollow noopener\">@soseiheptaresco<\/a>&nbsp;| X: <a href=\"https:\/\/twitter.com\/soseiheptaresco\" target=\"_blank\" rel=\"nofollow noopener\">@soseiheptaresco<\/a>&nbsp;| YouTube: <a href=\"https:\/\/www.youtube.com\/channel\/UCVIItbR5X7eoIwbgVrsR-dg\" target=\"_blank\" rel=\"nofollow noopener\">@soseiheptaresco<\/a>&nbsp;<\/p>\n<div>\n<table border=\"0\" cellspacing=\"0\" cellpadding=\"1\" class=\"prnbcc\">\n<tbody>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\"><sup>[1]<\/sup><\/span> Komatsu H et al., Anatomical Transcriptome of G Protein-Coupled Receptors Leads to the Identification of a Novel Therapeutic Candidate GPR52 for Psychiatric Disorders., PLoS One (2014), 9(2), e90134\/1-e90134\/16, 16 pp., <a href=\"https:\/\/doi.org\/10.1371\/journal.pone.0090134\" target=\"_blank\" class=\"prnews_a\" rel=\"nofollow noopener\">https:\/\/doi.org\/10.1371\/journal.pone.0090134<\/a><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\"><sup>[2] <\/sup><\/span>Setoh m et al., Discovery of the First Potent and Orally Available Agonist of the Orphan G-Protein-Coupled Receptor 52., J. Med. Chem. 2014, 57, 12, 5226\u20135237, June 2, 2014, <a href=\"https:\/\/doi.org\/10.1021\/jm5002919\" target=\"_blank\" class=\"prnews_a\" rel=\"nofollow noopener\">https:\/\/doi.org\/10.1021\/jm5002919<\/a><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\"><sup>[3]<\/sup><\/span> Komatsu, H. Novel Therapeutic GPCRs for Psychiatric Disorders, Int. J. Mol. Sci. 2015, 16, 14109-14121; doi: <a href=\"https:\/\/doi.org\/10.3390\/ijms160614109\" target=\"_blank\" class=\"prnews_a\" rel=\"nofollow noopener\">https:\/\/doi.org\/10.3390\/ijms160614109<\/a>.<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\"><sup>[4]<\/sup><\/span> Dixon L What It Will Take to Make Coordinated Specialty Care Available to Anyone Experiencing Early Schizophrenia: Getting Over the Hump. JAMA Psychiatry. 2017;74(1):7\u20138. doi:10.1001\/jamapsychiatry.2016.2665<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\"><sup>[5]<\/sup><\/span> Owen M et al., Schizophrenia. The Lancet. Volume 388, Issue 10039, 2\u20138 July 2016, Pages 86-97, <a href=\"https:\/\/doi.org\/10.1016\/S0140-6736(15)01121-6\" target=\"_blank\" class=\"prnews_a\" rel=\"nofollow noopener\">https:\/\/doi.org\/10.1016\/S0140-6736(15)01121-6<\/a><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\"><sup>[6]<\/sup><\/span> Roth RM et Al., Schizophrenia Research, Volume 98, Issues 1\u20133, January 2008, Pages 232-238, <a href=\"https:\/\/doi.org\/10.1016\/j.schres.2007.08.020\" target=\"_blank\" class=\"prnews_a\" rel=\"nofollow noopener\">https:\/\/doi.org\/10.1016\/j.schres.2007.08.020<\/a><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\"><sup>[7]<\/sup><\/span> Bleuler, M. Demential Praecox or the Group of Schizophrenias. (International Universities Press, New York, 1950).<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\"><sup>[8] <\/sup><\/span>Wang P et al., Discovery of Potent and Brain-Penetrant GPR52 Agonist that Suppresses Psychostimulant Behavior, J Med Chem. 2020 Nov 25; 63(22): 13951\u201313972, <a href=\"https:\/\/doi.org\/10.1021\/acs.jmedchem.0c01498\" target=\"_blank\" class=\"prnews_a\" rel=\"nofollow noopener\">https:\/\/doi.org\/10.1021\/acs.jmedchem.0c01498<\/a><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\"><sup>[9]<\/sup><\/span> Felsing et al., Structure Activity Relationships of Novel GPR52 Agonists that Suppress Psychostimulant Behavior, The FASEB Journal Volume 35, Issue S1, https:\/\/doi.org\/10.1096\/fasebj.2021.35.S1.04064<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\"><sup>[10]<\/sup><\/span> <a href=\"https:\/\/soseiheptares.com\/news\/851\/129\/Sosei-Heptares-Doses-First-Subject-in-Phase-I-Trial-with-HTL0048149-a-First-in-Class-GPR52-Agonist-for-Schizophrenia.html\" target=\"_blank\" class=\"prnews_a\" rel=\"nofollow noopener\">Press release &#8211; Sosei Heptares<\/a><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\"><sup>[11]<\/sup><\/span> Newcomer, J. W. Second-generation (atypical) antipsychotics and metabolic effects: a comprehensive literature review CNS Drugs 2005, 19 (Suppl. 1) 1\u2013 93.<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\"><sup>[12]<\/sup><\/span> Casey, D. E.&nbsp;Metabolic issues and cardiovascular disease in patients with psychiatric disorders&nbsp;Am. J. Med.&nbsp;2005,&nbsp;118&nbsp;(Suppl. 2)&nbsp;15S\u2013&nbsp;22S.<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\"><sup>[13]<\/sup><\/span> Taylor, D. M. Antipsychotics and QT prolongation Acta Psychiatr. Scand. 2003, 107, 85\u2013 957Antipsychotics and QT prolongationTaylor, D. M.Acta Psychiatrica Scandinavica (2003), 107 (2), 85-95.<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\"><sup>[14]<\/sup><\/span> <a href=\"https:\/\/doi.org\/10.1186\/ISRCTN17231793\" target=\"_blank\" class=\"prnews_a\" rel=\"nofollow noopener\">https:\/\/doi.org\/10.1186\/ISRCTN17231793<\/a><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\"><sup>[15] <\/sup><\/span><a href=\"https:\/\/www.clinicaltrials.gov\/study\/NCT05838625?term=ct-155&amp;rank=4\" target=\"_blank\" class=\"prnews_a\" rel=\"nofollow noopener\">https:\/\/www.clinicaltrials.gov\/study\/NCT05838625?term=ct-155&amp;rank=4<\/a><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table><\/div>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u5fb7\u56fd\u6bb7\u683c\u7ff0\u3001\u65e5\u672c\u4e1c\u4eac\u548c\u82f1\u56fd\u5251\u68652024\u5e743\u670815\u65e5 \/\u7f8e\u901a\u793e\/ &#8212; \u8fd1\u65e5\uff0c\u52c3\u6797\u683c\u6bb7\u683c\u7ff0\u548cSosei\u96c6\u56e2\uff08&quot;Sosei Heptares&quot;\uff1bTSE\uff1a4565\uff09\u5ba3\u5e03\u53cc\u65b9\u5df2\u7ecf\u8fbe\u6210\u4e00\u9879\u5168\u7403\u5408\u4f5c\u548c\u72ec\u5bb6\u9009\u62e9\u6743\u8bb8\u53ef\u534f\u8bae\u3002\u53cc\u65b9\u5408\u4f5c\u7684\u6838\u5fc3\u662f\u5f00\u53d1\u548c\u5546\u4e1a\u5316Sosei Heptares\u7684\u540c\u7c7b\u9996\u521bGPR52\u6fc0\u52a8\u5242\uff0cGPR52\u6fc0\u52a8\u5242\u662f\u4e00\u79cd\u65b0\u578bG\u86cb\u767d\u5076\u8054\u53d7\u4f53\uff08GPCR\uff09\u9776\u70b9\uff0c\u65e8\u5728\u540c\u65f6\u89e3\u51b3\u7cbe\u795e\u5206\u88c2\u75c7\u7684\u9633\u6027\u3001\u9634\u6027\u548c\u8ba4\u77e5\u75c7\u72b6\u6765\u6539\u5584\u60a3\u8005\u7684\u9884\u540e\u3002[1],[2],[3] \u7cbe\u795e\u5206\u88c2\u75c7\u662f\u4e00\u79cd\u4e25\u91cd\u7684\u75be\u75c5\uff0c\u5168\u7403\u5927\u7ea6\u6bcf100\u4eba\u4e2d\u5c31\u67091\u4eba\u53d7\u5230\u5f71\u54cd[4]\u3002\u5b83\u7684\u7279\u5f81\u662f\u4e09\u7c7b\u75c7\u72b6\u7fa4[5],[6]\uff1a&nbsp; \u9633\u6027\u75c7\u72b6\u2014\u2014\u5982\u7cbe\u795e\u75c5\u3001\u5984\u60f3\u548c\u5e7b\u89c9 \u9634\u6027\u75c7\u72b6\u2014\u2014\u5982\u793e\u4ea4\u5c01\u95ed\u548c\u51b7\u6f20 \u8ba4\u77e5\u75c7\u72b6\u2014\u2014\u5982\u6ce8\u610f\u529b\u3001\u8ba1\u5212\u548c\u8bb0\u5fc6\u7f3a\u9677 \u8fd9\u4e9b\u75c7\u72b6\u5bf9\u4eba\u4eec\u65e5\u5e38\u751f\u6d3b\u7684\u80fd\u529b\u4ea7\u751f\u4e86\u91cd\u5927\u5f71\u54cd\uff0c\u800c\u4e14\u5bf9\u7167\u987e\u8005\u548c\u6574\u4e2a\u793e\u4f1a\u4ea7\u751f\u5de8\u5927\u7684\u8d1f\u62c5\uff0c\u5c24\u5176\u662f\u56e0\u4e3a\u8be5\u75be\u75c5\u7684\u53d1\u75c5\u5e74\u9f84\u901a\u5e38\u572820\u591a\u5c81[7]\u3002\u867d\u7136\u9633\u6027\u75c7\u72b6\u53ef\u4ee5\u7528\u6297\u7cbe\u795e\u75c5\u836f\u7269\u7a33\u5b9a\uff0c\u4f46\u662f\u5176\u4e2d\u4e00\u4e9b\u836f\u7269\u53ef\u80fd\u6709\u526f\u4f5c\u7528\uff0c\u76ee\u524d\u8fd8\u6ca1\u6709\u83b7\u6279\u7684\u836f\u7269\u53ef\u7528\u4e8e\u9634\u6027\u6216\u8ba4\u77e5\u75c7\u72b6\u3002 \u9488\u5bf9GPR52\u5f00\u53d1\u7684\u65b0\u578b\u7cbe\u795e\u5206\u88c2\u75c7\u6cbb\u7597\u65b9\u6cd5\u6709\u6f5c\u529b\u89e3\u51b3\u7cbe\u795e\u5206\u88c2\u75c7\u7684\u8fd9\u4e09\u4e2a\u65b9\u9762[1],[2]\uff0c\u63d0\u4f9b\u4e00\u79cd\u5168\u65b0\u7684\u7cbe\u51c6\u6cbb\u7597\u65b9\u6cd5\u3002\u8fd9\u57fa\u4e8e\u8be5\u53d7\u4f53\u4f4d\u4e8e\u5927\u8111\u7684\u4e24\u4e2a\u533a\u57df\uff0c\u8fd9\u4e24\u4e2a\u533a\u57df\u5206\u522b\u9a71\u52a8\u9633\u6027\uff08\u7eb9\u72b6\u4f53\uff09\u548c\u9634\u6027\u53ca\u8ba4\u77e5\u75c7\u72b6\uff08\u524d\u989d\u53f6\u76ae\u5c42\uff09\u3002GPR52\u6fc0\u52a8\u4f5c\u7528\u53ef\u4ee5\u5e73\u9759\u7eb9\u72b6\u4f53\u540c\u65f6\u589e\u5f3a\u989d\u53f6\u76ae\u5c42\u529f\u80fd\uff0c\u4ece\u800c\u5b9e\u73b0\u8fdb\u4e00\u6b65\u7684\u7cbe\u51c6\u6cbb\u7597[8]\u3002 \u52c3\u6797\u683c\u6bb7\u683c\u7ff0\u5168\u7403\u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf\u53d1\u73b0\u7814\u7a76\u8d1f\u8d23\u4ebaHugh Marston\u8868\u793a\uff1a&quot;\u6211\u4eec\u975e\u5e38\u9ad8\u5174\u80fd\u4e0eSosei Heptares\u516c\u53f8\u5c31\u8fd9\u4e00\u65b0\u578b\u7597\u6cd5\u5efa\u7acb\u5408\u4f5c\uff0c\u4ee5\u89e3\u51b3\u7cbe\u795e\u5206\u88c2\u75c7\u60a3\u8005\u5de8\u5927\u672a\u6ee1\u8db3\u7684\u9700\u6c42\u3002\u6b64\u9879\u5408\u4f5c\u4e0e\u6211\u4eec\u5176\u4ed6\u7684\u5f00\u53d1\u8ba1\u5212\u9ad8\u5ea6\u4e92\u8865\uff0c\u65e8\u5728\u4e3a\u7cbe\u795e\u5065\u5eb7\u75be\u75c5\u5e26\u6765\u65b0\u7684\u7cbe\u51c6\u533b\u5b66\u65b9\u6cd5\uff0c\u6211\u4eec\u5e0c\u671b\u901a\u8fc7\u8fd9\u4e00\u7597\u6cd5\u6539\u53d8\u7cbe\u795e\u5206\u88c2\u75c7\u60a3\u8005\u7684\u751f\u6d3b\u3002&quot; Heptares Therapeutics\u603b\u88c1\u3001Sosei Heptares\u82f1\u56fd\u7814\u53d1\u8d1f\u8d23\u4ebaMatt Barnes\u8868\u793a\uff1a&quot;\u6b64\u6b21\u5408\u4f5c\u7a81\u663e\u4e86GPR52\u5728\u4e34\u5e8a\u524d\u7814\u7a76\u4e2d\u4f5c\u4e3a\u4e00\u79cd\u65b0\u578b\u7684\u3001\u540c\u7c7b\u9996\u521b\u9776\u70b9\u5728\u6cbb\u7597\u7cbe\u795e\u5206\u88c2\u75c7\u548c\u76f8\u5173\u795e\u7ecf\u75be\u75c5\u7597\u6cd5\u4e0a\u6240\u5c55\u73b0\u7684\u5de8\u5927\u6f5c\u529b\u3002\u6211\u4eec\u5f88\u9ad8\u5174\u80fd\u4e0e\u52c3\u6797\u683c\u6bb7\u683c\u7ff0\u5408\u4f5c\uff0c\u5e76\u5229\u7528\u5176\u5728\u795e\u7ecf\u75be\u75c5\u7814\u7a76\u548c\u521b\u65b0\u65b9\u9762\u7684\u9886\u5148\u4e13\u957f\u3002\u6211\u4eec\u5c06\u5171\u540c\u4e13\u6ce8\u4e8e\u52a0\u901f\u8fd9\u4e2a\u9ad8\u5ea6\u521b\u65b0\u9879\u76ee\u7684\u5f00\u53d1\uff0c\u8be5\u9879\u76ee\u76ee\u524d\u6b63\u5728\u8fdb\u884cI\u671f\u4e34\u5e8a\u7814\u7a76\uff0c\u4e3b\u8981\u9762\u5411\u6709\u9700\u8981\u7684\u60a3\u8005\u3002&quot; \u5173\u4e8e\u5408\u4f5c\u534f\u8bae&nbsp; \u6839\u636e\u534f\u8bae\uff0cSosei Heptares \u5c06\u4ece\u52c3\u6797\u683c\u6bb7\u683c\u7ff0\u83b7\u5f97&nbsp;2500 \u4e07\u6b27\u5143\u7684\u9884\u4ed8\u6b3e\uff0c\u5e76\u6709\u8d44\u683c\u83b7\u5f97&nbsp;6000 \u4e07\u6b27\u5143\u7684\u9009\u62e9\u6743\u884c\u4f7f\u4ed8\u6b3e\uff0c\u4ee5\u53ca\u8fdb\u4e00\u6b65\u5f00\u53d1\u3001\u76d1\u7ba1\u548c\u5546\u4e1a\u5316\u91cc\u7a0b\u7891\u4ed8\u6b3e\uff0c\u603b\u8ba1\u9ad8\u8fbe&nbsp;6.7 \u4ebf\u6b27\u5143\uff0c\u4ee5\u53ca\u4e34\u5e8a\u9636\u6bb5\u8d44\u4ea7\u5728\u52c3\u6797\u683c\u6bb7\u683c\u7ff0\u672a\u6765\u4ea7\u54c1\u9500\u552e\u4e2d\u7684\u5206\u7ea7\u9500\u552e\u5206\u6210\u3002 \u6839\u636e\u534f\u8bae\u6761\u6b3e\uff0c\u52c3\u6797\u683c\u6bb7\u683c\u7ff0\u62e5\u6709\u72ec\u5bb6\u9009\u62e9\u6743\uff0c\u5728\u5b8c\u6210 Sosei Heptares \u516c\u53f8\u9488\u5bf9HTL0048149\uff08\u4e00\u79cd\u540c\u7c7b\u9996\u521b GPR52 \u6fc0\u52a8\u5242\uff09\u6b63\u5728\u8fdb\u884c\u7684 1 \u671f\u8bd5\u9a8c\u3001\u968f\u540e\u7684 1b \u671f\u8bd5\u9a8c\u4ee5\u53ca\u8fdb\u4e00\u6b65 2 \u671f\u8bd5\u9a8c\u7533\u8bf7\u540e\uff0c\u6709\u6743\u83b7\u53d6 Sosei Heptares \u7684 GPR52 \u6fc0\u52a8\u5242\u7684\u72ec\u5bb6\u8bb8\u53ef\u3002Sosei Heptares \u5c06\u4fdd\u7559\u5bf9\u8fd9\u4e9b\u8bd5\u9a8c\u7684\u63a7\u5236\u6743\uff0c\u5e76\u8d5e\u52a9\u8fd9\u4e9b\u8bd5\u9a8c\uff0c\u76f4\u5230\u9884\u8ba1\u4e8e 2025 \u5e74\u884c\u4f7f\u9009\u62e9\u6743\u4e3a\u6b62\u3002\u83b7\u5f97\u8bb8\u53ef\u7684\u4ea7\u54c1\u7ec4\u5408\u5c06\u5305\u62ec HTL0048149 \u4ee5\u53ca Sosei Heptares \u5229\u7528\u5176 StaR&reg; \u6280\u672f\u548c\u57fa\u4e8e\u7ed3\u6784\u7684\u836f\u7269\u8bbe\u8ba1 (SBDD)&hellip; <a class=\"read-more\" href=\"https:\/\/www.xinwengao.com\/cn\/pr\/20240315143200107998\">Read More<\/a><\/p>\n","protected":false},"author":556,"featured_media":0,"comment_status":"close","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1965],"tags":[],"class_list":["post-107998","post","type-post","status-publish","format-standard","hentry","category-partnerships"],"amp_enabled":true,"_links":{"self":[{"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/posts\/107998","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/users\/556"}],"replies":[{"embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/comments?post=107998"}],"version-history":[{"count":1,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/posts\/107998\/revisions"}],"predecessor-version":[{"id":107999,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/posts\/107998\/revisions\/107999"}],"wp:attachment":[{"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/media?parent=107998"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/categories?post=107998"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/tags?post=107998"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}