{"id":107142,"date":"2024-03-08T13:19:00","date_gmt":"2024-03-08T06:19:00","guid":{"rendered":"https:\/\/www.xinwengao.com\/cn\/pr\/20240308131900107142"},"modified":"2024-03-09T00:27:24","modified_gmt":"2024-03-08T16:27:24","slug":"%e7%99%be%e6%b5%8e%e7%a5%9e%e5%b7%9e%e5%ae%a3%e5%b8%83%e7%99%be%e6%82%a6%e6%b3%bd%e8%8e%b7fda%e5%8a%a0%e9%80%9f%e6%89%b9%e5%87%86%e7%94%a8%e4%ba%8e%e6%b2%bb%e7%96%97%e5%a4%8d%e5%8f%91%e6%88%96","status":"publish","type":"post","link":"https:\/\/www.xinwengao.com\/cn\/pr\/20240308131900107142","title":{"rendered":"\u767e\u6d4e\u795e\u5dde\u5ba3\u5e03\u767e\u60a6\u6cfd\u00ae\u83b7FDA\u52a0\u901f\u6279\u51c6\u7528\u4e8e\u6cbb\u7597\u590d\u53d1\u6216\u96be\u6cbb\u6027\u6ee4\u6ce1\u6027\u6dcb\u5df4\u7624"},"content":{"rendered":"<p 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Mobasher\u533b\u5b66\u535a\u58eb\u53ca\u516c\u5171\u536b\u751f\u7855\u58eb\u8868\u793a\uff1a\u201c\u767e\u60a6\u6cfd<sup>&reg;<\/sup>\u7684\u52a0\u901f\u6279\u51c6\u5177\u6709\u91cd\u5927\u610f\u4e49\uff0c\u4e3a\u521d\u59cb\u6cbb\u7597\u65e0\u6548\u6216\u590d\u53d1\u7684\u7f8e\u56fd\u6ee4\u6ce1\u6027\u6dcb\u5df4\u7624\u60a3\u8005\u63d0\u4f9b\u4e86\u9996\u4e2a\u4e5f\u662f\u552f\u4e00\u4e00\u6b3eBTK\u6291\u5236\u5242\u7684\u6cbb\u7597\u65b9\u6848\u3002\u767e\u60a6\u6cfd<sup>&reg;<\/sup>\u662f\u8fc4\u4eca\u4e3a\u6b62\u552f\u4e00\u4e00\u6b3e\u5728\u6b64\u7c7b\u6076\u6027\u80bf\u7624\u4e2d\u5c55\u793a\u6709\u6548\u6027\u7684BTK\u6291\u5236\u5242\uff0c\u5176\u5df2\u83b7\u6279\u4e94\u9879\u80bf\u7624\u9002\u5e94\u75c7\uff0c\u5728\u5168\u7403\u540c\u7c7b\u836f\u7269\u4e2d\u9002\u5e94\u75c7\u8986\u76d6\u6700\u4e3a\u5e7f\u6cdb\u3002\u8fd9\u5145\u5206\u5c55\u73b0\u4e86\u767e\u60a6\u6cfd<sup>&reg;<\/sup>\u5dee\u5f02\u5316\u7684\u4e34\u5e8a\u7279\u5f81\uff0c\u4ee5\u53ca\u6211\u4eec\u575a\u5b9a\u4e0d\u79fb\u5c06\u8fd9\u9879\u91cd\u8981\u6cbb\u7597\u9009\u62e9\u5e26\u7ed9\u5168\u7403\u60a3\u8005\u7684\u51b3\u5fc3\u3002\u201d<\/p>\n<p>\u6b64\u6b21\u767e\u60a6\u6cfd<sup>&reg;<\/sup>\u83b7\u5f97FDA\u52a0\u901f\u6279\u51c6\u7528\u4e8e\u6cbb\u7597R\/R FL\u662f\u57fa\u4e8eROSEWOOD\u8bd5\u9a8c\uff08<a href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT03332017\" target=\"_blank\" rel=\"nofollow noopener\">NCT03332017<\/a>\uff09\u4e2d\u7ecf\u72ec\u7acb\u5ba1\u67e5\u59d4\u5458\u4f1a\uff08IRC\uff09\u8bc4\u4f30\u7684\u603b\u7f13\u89e3\u7387\uff08ORR\uff09\u7ed3\u679c\u3002\u8be5\u9002\u5e94\u75c7\u540e\u7eed\u7684\u5b8c\u5168\u6279\u51c6\u5c06\u53d6\u51b3\u4e8e\u786e\u8bc1\u6027\u8bd5\u9a8cMAHOGANY\uff08<a href=\"https:\/\/clinicaltrials.gov\/study\/NCT05100862?term=MAHOGANY&amp;intr=BGB-3111&amp;rank=1\" target=\"_blank\" rel=\"nofollow noopener\">NCT05100862<\/a>\uff09\u4e2d\u5bf9\u4e34\u5e8a\u83b7\u76ca\u7684\u9a8c\u8bc1\u548c\u63cf\u8ff0\u3002\u6b64\u524dFDA\u5df2\u6388\u4e88\u767e\u60a6\u6cfd<sup>&reg;<\/sup>\u7528\u4e8e\u6cbb\u7597R\/R FL\u7684\u5feb\u901f\u901a\u9053\u8d44\u683c\u3001\u201c\u5b64\u513f\u836f\u201d\u8d44\u683c\u8ba4\u5b9a\u3002<\/p>\n<p>ROSEWOOD\u8bd5\u9a8c\u662f\u4e00\u9879\u5168\u7403\u6027\u3001\u968f\u673a\u3001\u5f00\u653e\u60272\u671f\u7814\u7a76\uff0c\u65e8\u5728\u6bd4\u8f83\u767e\u60a6\u6cfd<sup>&reg;<\/sup>\u8054\u5408\u5965\u59a5\u73e0\u5355\u6297\u548c\u5965\u59a5\u73e0\u5355\u6297\u5355\u836f\u6cbb\u7597\uff0c\u5728217\u4f8b\u65e2\u5f80\u63a5\u53d7\u8fc7\u81f3\u5c11\u4e8c\u7ebf\u7cfb\u7edf\u6cbb\u7597\u7684R\/R FL\u60a3\u8005\u4e2d\u7684\u6cbb\u7597\u6548\u679c\u3002\u5728\u8be5\u7814\u7a76\u4e2d\uff0c\u7ecfIRC\u8bc4\u4f30\uff0c\u767e\u60a6\u6cfd<sup>&reg;<\/sup>\u8054\u5408\u5965\u59a5\u73e0\u5355\u6297\u7ec4\u7684ORR\u8fbe\u523069%\uff0c\u800c\u5965\u59a5\u73e0\u5355\u6297\u5355\u836f\u7ec4\u7684ORR\u4e3a46%\uff08<i>P<\/i>=0.0012\uff09\uff0c\u4e2d\u4f4d\u968f\u8bbf\u65f6\u95f4\u7ea6\u4e3a 20 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<\/sup>\u5728\u63a5\u53d7\u767e\u60a6\u6cfd<sup>&reg;<\/sup>\u8054\u5408\u5965\u59a5\u73e0\u5355\u6297\u6cbb\u7597\u7684\u60a3\u8005\u4e2d\u4e25\u91cd\u7684\u4e0d\u826f\u4e8b\u4ef6\u53d1\u751f\u7387\u4e3a35%\u3002\u670917%\u7684\u60a3\u8005\u7531\u4e8e\u4e0d\u826f\u4e8b\u4ef6\u800c\u7ec8\u6b62\u767e\u60a6\u6cfd<sup>&reg;<\/sup>\u6cbb\u7597\u3002<\/p>\n<p>\u5fb7\u514b\u8428\u65af\u5927\u5b66MD\u5b89\u5fb7\u68ee\u764c\u75c7\u4e2d\u5fc3\u764c\u75c7\u533b\u5b66\u90e8\u95e8\u8d1f\u8d23\u4eba\u517c\u6dcb\u5df4\u7624\/\u9aa8\u9ad3\u7624\u79d1\u4e3b\u4efbChristopher Flowers\u533b\u5b66\u535a\u58eb\u8868\u793a\uff1a\u201c\u7f79\u60a3\u6ee4\u6ce1\u6027\u6dcb\u5df4\u7624\u7684\u60a3\u8005\u65f6\u5e38\u7ecf\u5386\u75be\u75c5\u590d\u53d1\uff0c\u6216\u6cbb\u7597\u65e0\u7f13\u89e3\uff0c\u4ed6\u4eec\u5728\u75c5\u7a0b\u4e2d\u9700\u8981\u66f4\u591a\u7684\u6cbb\u7597\u9009\u62e9\u3002\u800cROSEWOOD\u8bd5\u9a8c\u7ed3\u679c\u663e\u793a\uff0c\u4f7f\u7528\u6cfd\u5e03\u66ff\u5c3c\u8054\u5408\u5965\u59a5\u73e0\u5355\u6297\u6cbb\u7597\u590d\u53d1\u6216\u96be\u6cbb\u6027\u6ee4\u6ce1\u6027\u6dcb\u5df4\u7624\u60a3\u8005\u5177\u6709\u663e\u8457\u7684\u4e34\u5e8a\u4f18\u52bf\u3002\u201d<\/p>\n<p>\u56fd\u9645\u6ee4\u6ce1\u6027\u6dcb\u5df4\u7624\u57fa\u91d1\u4f1a\u8868\u793a\uff1a\u201c\u7f79\u60a3\u6ee4\u6ce1\u6027\u6dcb\u5df4\u7624\u901a\u5e38\u4f1a\u5bf9\u60a3\u8005\u7684\u751f\u6d3b\u5e26\u6765\u5de8\u5927\u5f71\u54cd\uff0c\u4e14\u76ee\u524d\u5728\u6cbb\u7597\u4e0a\u6781\u5177\u6311\u6218\uff0c\u5c24\u5176\u662f\u90a3\u4e9b\u65e2\u5f80\u63a5\u53d7\u8fc7\u6cbb\u7597\u4f46\u75c5\u60c5\u4ecd\u5728\u8fdb\u5c55\u6216\u7ecf\u5386\u590d\u53d1\u7684\u60a3\u8005\u3002\u7136\u800c\uff0c\u4e34\u5e8a\u8bc1\u660e\u6709\u6548\u4e14\u8010\u53d7\u6027\u826f\u597d\u7684\u65b0\u6cbb\u7597\u65b9\u6848\u7684\u51fa\u73b0\uff0c\u4f8b\u5982\u4f7f\u7528\u6cfd\u5e03\u66ff\u5c3c\u7b49\u65b0\u4e00\u4ee3BTK\u6291\u5236\u5242\u4e0e\u73b0\u6709\u7597\u6cd5\u7684\u7ed3\u5408\uff0c\u4e3a\u665a\u671f\u6ee4\u6ce1\u6027\u6dcb\u5df4\u7624\u60a3\u8005\u5e26\u6765\u4e86\u5e0c\u671b\u3002\u201d<\/p>\n<p>\u9664\u4e86R\/R 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border=\"0\" cellspacing=\"0\" cellpadding=\"1\" class=\"prnbcc\">\n<tbody>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\"><sup>i<\/sup> Zinsani PL, et al. ROSEWOOD: A Phase II Randomized Study of Zanubrutinib Plus Obinutuzumab Versus Obinutuzumab Monotherapy in Patients With Relapsed or Refractory Follicular Lymphoma. <i>J Clin Oncol<\/i>. 2023;41(33):5107-5117.<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\"><sup>ii<\/sup>Leukemia &amp; Lymphoma Society. Treatment for Indolent NHL Subtypes. Accessed February 16, 2024. Available at: <a href=\"https:\/\/www.lls.org\/lymphoma\/non-hodgkin-lymphoma\/nhl-subtypes\/treatment-indolent-nhl-subtypes\" target=\"_blank\" class=\"prnews_a\" rel=\"nofollow noopener\">https:\/\/www.lls.org\/lymphoma\/non-hodgkin-lymphoma\/nhl-subtypes\/treatment-indolent-nhl-subtypes<\/a>.<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\"><sup>iii<\/sup>&nbsp;Leukemia &amp; Lymphoma Society. Follicular Lymphoma (FL). Accessed February 16, 2024. Available at: <a href=\"https:\/\/www.lls.org\/research\/follicular-lymphoma-fl#:~:text=FL%20has%20an%20annual%20incidence,having%20a%20higher%20survival%20rate\" target=\"_blank\" class=\"prnews_a\" rel=\"nofollow noopener\">https:\/\/www.lls.org\/research\/follicular-lymphoma-fl#:~:text=FL%20has%20an%20annual%20incidence,having%20a%20higher%20survival%20rate<\/a>.<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\"><sup>iV<\/sup> Cleveland Clinic. Follicular Lymphoma. March 25, 2022. Accessed February 16, 2024. Available at: <a href=\"https:\/\/my.clevelandclinic.org\/health\/diseases\/22606-follicular-lymphoma\" target=\"_blank\" class=\"prnews_a\" rel=\"nofollow noopener\">https:\/\/my.clevelandclinic.org\/health\/diseases\/22606-follicular-lymphoma<\/a>.<\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table><\/div>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u767e\u60a6\u6cfd&reg;\u662f\u9996\u4e2a\u4e14\u552f\u4e00\u4e00\u6b3e\u83b7\u6279\u4e94\u9879\u80bf\u7624\u9002\u5e94\u75c7\uff0c\u4e5f\u662f\u9996\u4e2a\u4e14\u552f\u4e00\u83b7\u6279\u7528\u4e8e\u6ee4\u6ce1\u6027\u6dcb\u5df4\u7624\u7684BTK\u6291\u5236\u5242 \u6b64\u6b21\u6279\u51c6\u57fa\u4e8eROSEWOOD\u8bd5\u9a8c\u83b7\u5f97\u7684\u79ef\u6781\u7ed3\u679c\uff0c\u8be5\u7814\u7a76\u663e\u793a\u76f8\u6bd4\u5965\u59a5\u73e0\u5355\u6297\u5355\u836f\u6cbb\u7597\uff0c\u767e\u60a6\u6cfd&reg;\u4e0e\u5965\u59a5\u73e0\u5355\u6297\u8054\u5408\u6cbb\u7597\u53d6\u5f97\u66f4\u9ad8\u7684\u603b\u7f13\u89e3\u7387 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\u53c2\u8003\u6587\u732e i Zinsani PL, et al. ROSEWOOD: A Phase II Randomized Study of&hellip; <a class=\"read-more\" href=\"https:\/\/www.xinwengao.com\/cn\/pr\/20240308131900107142\">Read More<\/a><\/p>\n","protected":false},"author":556,"featured_media":0,"comment_status":"close","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1965],"tags":[],"class_list":["post-107142","post","type-post","status-publish","format-standard","hentry","category-partnerships"],"amp_enabled":true,"_links":{"self":[{"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/posts\/107142","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/users\/556"}],"replies":[{"embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/comments?post=107142"}],"version-history":[{"count":1,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/posts\/107142\/revisions"}],"predecessor-version":[{"id":107143,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/posts\/107142\/revisions\/107143"}],"wp:attachment":[{"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/media?parent=107142"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/categories?post=107142"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/tags?post=107142"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}