{"id":107026,"date":"2024-03-06T08:01:00","date_gmt":"2024-03-06T01:01:00","guid":{"rendered":"https:\/\/www.xinwengao.com\/cn\/pr\/20240306080100107026"},"modified":"2024-03-07T00:27:40","modified_gmt":"2024-03-06T16:27:40","slug":"%e3%80%90aacr-2024%e3%80%91%e4%ba%9a%e7%9b%9b%e5%8c%bb%e8%8d%af%e5%ae%a3%e5%b8%83%e5%b0%86%e5%9c%a82024%e5%b9%b4%e7%be%8e%e5%9b%bd%e7%99%8c%e7%97%87%e7%a0%94%e7%a9%b6%e5%8d%8f%e4%bc%9a%e5%b9%b4","status":"publish","type":"post","link":"https:\/\/www.xinwengao.com\/cn\/pr\/20240306080100107026","title":{"rendered":"\u3010AACR 2024\u3011\u4e9a\u76db\u533b\u836f\u5ba3\u5e03\u5c06\u57282024\u5e74\u7f8e\u56fd\u764c\u75c7\u7814\u7a76\u534f\u4f1a\u5e74\u4f1a\u4e0a\u516c\u5e03\u4e09\u9879\u6700\u65b0\u4e34\u5e8a\u524d\u8fdb\u5c55"},"content":{"rendered":"\n\n\n
\"\"<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\u4e2d\u56fd\u82cf\u5dde\u548c\u7f8e\u56fd\u9a6c\u91cc\u5170\u5dde\u7f57\u514b\u7ef4\u5c14\u5e02<\/span>2024\u5e743\u67086\u65e5<\/span> \/\u7f8e\u901a\u793e\/ — \u81f4\u529b\u4e8e\u5728\u80bf\u7624\u3001\u4e59\u809d\u53ca\u4e0e\u8870\u8001\u76f8\u5173\u75be\u75c5\u7b49\u6cbb\u7597\u9886\u57df\u5f00\u53d1\u521b\u65b0\u836f\u7269\u7684\u9886\u5148\u7684\u751f\u7269\u533b\u836f\u4f01\u4e1a\u2014\u2014\u4e9a\u76db\u533b\u836f\uff086855.HK\uff09\u4eca\u65e5\u5ba3\u5e03\uff0c\u516c\u53f8\u5171\u6709\u4e09\u9879\u4e34\u5e8a\u524d\u7814\u7a76\u8fdb\u5c55\u5165\u90092024\u5e74\u7f8e\u56fd\u764c\u75c7\u7814\u7a76\u534f\u4f1a\u5e74\u4f1a\uff08AACR 2024\uff09\uff0c\u6d89\u53ca\u516c\u53f8\u539f\u521b1\u7c7b\u65b0\u836f\u5965\u96f7\u5df4\u66ff\u5c3c\uff08\u5546\u54c1\u540d\uff1a\u8010\u7acb\u514b®<\/sup>\uff09\u3001MDM2-p53 \u6291\u5236\u5242APG-115\u3001FAK\/ALK\/ROS1\u4e09\u8054\u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5242APG-2449\u548c\u80da\u80ce\u5916\u80da\u5c42\u53d1\u80b2\u86cb\u767d\uff08EED\uff09\u6291\u5236\u5242APG-5918\u56db\u4e2a\u91cd\u8981\u54c1\u79cd\u3002\u6458\u8981\u5185\u5bb9\u73b0\u5df2\u5728AACR\u5b98\u7f51\u516c\u5e03\u3002<\/p>\n

\n<\/p><\/div>\n

\u7f8e\u56fd\u764c\u75c7\u7814\u7a76\u534f\u4f1a\uff08AACR\uff09\u5e74\u4f1a\u662f\u5168\u7403\u5386\u53f2\u6700\u60a0\u4e45\u3001\u89c4\u6a21\u6700\u5927\u7684\u80bf\u7624\u7814\u7a76\u5b66\u672f\u4f1a\u8bae\u4e4b\u4e00\u3002\u4f1a\u8bae\u5173\u6ce8\u9ad8\u8d28\u91cf\u80bf\u7624\u7814\u7a76\u53ca\u521b\u65b0\u7684\u5404\u4e2a\u65b9\u9762\uff0c\u662f\u5168\u7403\u80bf\u7624\u7814\u7a76\u7684\u7126\u70b9\uff0c\u5c06\u6c47\u96c6\u80bf\u7624\u9886\u57df\u7684\u6700\u524d\u6cbf\u7684\u7814\u7a76\u6210\u679c\u3002\u672c\u5c4aAACR\u5e74\u4f1a\u5c06\u4e8e\u5f53\u5730\u65f6\u95f42024\u5e744\u67085\u65e5-10\u65e5\u5728\u7f8e\u56fd\u5723\u5730\u4e9a\u54e5\u4e3e\u884c\u3002<\/p>\n

\u4e9a\u76db\u533b\u836f\u4e09\u9879\u4e34\u5e8a\u524d\u7814\u7a76\u7684\u6458\u8981\u4fe1\u606f\u5982\u4e0b\uff1a<\/p>\n

Olverembatinib, a novel multikinase inhibitor, demonstrates superior antitumor activity in succinate dehydrogenase (SDH)-deficient neoplasms<\/b><\/p>\n

\u65b0\u578b\u591a\u9776\u70b9\u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5242\u5965\u96f7\u5df4\u66ff\u5c3c\u5728<\/b>SDH\u7f3a\u9677\u578b\u80bf\u7624\u4e2d\u663e\u793a\u51fa\u4f18\u5f02\u7684\u6297\u80bf\u7624\u4f5c\u7528<\/b><\/p>\n

    \n
  • \u6458\u8981\u7f16\u53f7\uff1a1971<\/li>\n
  • \u5206\u4f1a\u573a\u7c7b\u522b\uff1aExperimental and Molecular Therapeutics\uff08\u5b9e\u9a8c\u6027\u4e0e\u5206\u5b50\u7597\u6cd5\uff09<\/li>\n
  • \u5206\u4f1a\u573a\u6807\u9898\uff1aKinase and Phosphatase Inhibitors 2\uff08\u6fc0\u9176\u548c\u78f7\u9178\u9176\u6291\u5236\u52422\uff09<\/li>\n
  • \u5c55\u793a\u65f6\u95f4\uff1a
    \uff08\u5f53\u5730\u65f6\u95f4\uff092024\u5e744\u67088\u65e5\uff08\u5468\u4e00\uff099:00 AM – 12:30 PM<\/span>
    \uff08\u5317\u4eac\u65f6\u95f4\uff092024\u5e744\u67089\u65e5\uff08\u5468\u4e8c\uff0900:00 – 03:30<\/li>\n<\/ul>\n

    \u8fd9\u9879\u4e34\u5e8a\u524d\u7814\u7a76\u7684\u7ed3\u679c\u663e\u793a\uff0c\u5728SDH\u7f3a\u9677\u7684\u80bf\u7624\u7ec6\u80de\u4e2d\uff0c\u5965\u96f7\u5df4\u66ff\u5c3c\u663e\u793a\u51fa\u4f18\u4e8e\u5176\u4ed6\u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5242\u7684\u836f\u6548\u3002\u673a\u5236\u7814\u7a76\u8868\u660e\uff0c\u5965\u96f7\u5df4\u66ff\u5c3c\u901a\u8fc7\u8c03\u8282\u7f3a\u6c27\u3001\u65b0\u8840\u7ba1\u751f\u6210\u3001\u7ec6\u80de\u589e\u6b96\u548c\u51cb\u4ea1\u7b49\u4e0eSDH\u7f3a\u9677\u578b\u80bf\u7624\u53d1\u751f\u76f8\u5173\u7684\u591a\u4e2a\u4fe1\u53f7\u901a\u8def\u53d1\u6325\u6297\u80bf\u7624\u4f5c\u7528\uff0c\u4e3a\u5965\u96f7\u5df4\u66ff\u5c3c\u5728\u8be5\u79cd\u5f3a\u70c8\u672a\u6ee1\u8db3\u4e34\u5e8a\u9700\u6c42\u7684\u80bf\u7624\u6cbb\u7597\u5e94\u7528\u63d0\u4f9b\u4e86\u79d1\u5b66\u4f9d\u636e\u3002<\/p>\n

    Embryonic ectoderm development (EED) inhibitor APG-5918 (EEDi-5273) and MDM2 inhibitor alrizomadlin (APG-115) synergistically inhibit tumor growth in preclinical models of prostate cancer (PCa)<\/b><\/p>\n

    \u80da\u80ce\u5916\u80da\u5c42\u53d1\u80b2<\/b> (EED) \u6291\u5236\u5242APG-5918\uff08EEDi-5273\uff09\u8054\u5408MDM2\u6291\u5236\u5242alrizomadlin\uff08APG-115\uff09\u5728\u524d\u5217\u817a\u764c (PCa) \u4e34\u5e8a\u524d\u6a21\u578b\u4e2d\u534f\u540c\u6291\u5236\u80bf\u7624\u751f\u957f<\/b><\/p>\n

      \n
    • \u6458\u8981\u7f16\u53f7\uff1a3223<\/li>\n
    • \u5206\u4f1a\u573a\u7c7b\u522b\uff1aExperimental and Molecular Therapeutics\uff08\u5b9e\u9a8c\u6027\u4e0e\u5206\u5b50\u7597\u6cd5\uff09<\/li>\n
    • \u5206\u4f1a\u573a\u6807\u9898\uff1aEpigenetic Targets\uff08\u8868\u89c2\u9057\u4f20\u5b66\u9776\u70b9\uff09<\/li>\n
    • \u5c55\u793a\u65f6\u95f4\uff1a
      \uff08\u5f53\u5730\u65f6\u95f4\uff092024\u5e744\u67088\u65e5\uff08\u5468\u4e00\uff091:30 PM – 5:00 PM<\/span>
      \uff08\u5317\u4eac\u65f6\u95f4\uff092024\u5e744\u67089\u65e5\uff08\u5468\u4e8c\uff0904:30 – 08:00<\/li>\n<\/ul>\n

      \u8fd9\u9879\u7814\u7a76\u7ed3\u679c\u663e\u793a\uff0c\u9776\u5411\u8054\u5408EED\u548cMDM2\u5728\u524d\u5217\u817a\u764c\u4e34\u5e8a\u524d\u6a21\u578b\u4e2d\u901a\u8fc7\u8c03\u8282DNA\u7532\u57fa\u5316\u3001\u7ec6\u80de\u5468\u671f\u53ca\u51cb\u4ea1\u76f8\u5173\u9014\u5f84\u663e\u793a\u51fa\u534f\u540c\u589e\u5f3a\u6297\u80bf\u7624\u6d3b\u6027\uff1b\u8be5\u7814\u7a76\u6210\u679c\u4e3a\u4e34\u5e8a\u5f00\u53d1APG-5918\u548cAPG-115\u8054\u5408\u6cbb\u7597\u5728\u524d\u5217\u817a\u764c\u4e2d\u7684\u5e94\u7528\u63d0\u4f9b\u4e86\u79d1\u5b66\u4f9d\u636e\u3002<\/p>\n

      APG-2449, a novel focal adhesion kinase (FAK) inhibitor, inhibits metastasis and enhances the antitumor efficacy of PEGylated liposome doxorubicin (PLD) in epithelial ovarian cancer (EOC)<\/b><\/p>\n

      \u65b0\u578b\u9ecf\u7740\u6591\u6fc0\u9176<\/b>(FAK)\u6291\u5236\u5242APG-2449\u5728\u4e0a\u76ae\u6027\u5375\u5de2\u764c(EOC)\u4e2d\u53ef\u6291\u5236\u80bf\u7624\u7ec6\u80de\u7684\u8f6c\u79fb\u5e76\u589e\u5f3a\u805a\u4e59\u4e8c\u9187\u8102\u8d28\u4f53\u963f\u9709\u7d20(PLD)\u7684\u6297\u80bf\u7624\u4f5c\u7528<\/b><\/p>\n

        \n
      • \u6458\u8981\u7f16\u53f7\uff1a4569<\/li>\n
      • \u5206\u4f1a\u573a\u7c7b\u522b\uff1aExperimental and Molecular Therapeutics\uff08\u5b9e\u9a8c\u6027\u4e0e\u5206\u5b50\u7597\u6cd5\uff09<\/li>\n
      • \u5206\u4f1a\u573a\u6807\u9898\uff1aDrug Combinations\uff08\u836f\u7269\u8054\u7528\uff09<\/li>\n
      • \u5c55\u793a\u65f6\u95f4\uff1a
        \uff08\u5f53\u5730\u65f6\u95f4\uff092024\u5e744\u67089\u65e5\uff08\u5468\u4e8c\uff099:00 AM – 12:30 PM<\/span>
        \uff08\u5317\u4eac\u65f6\u95f4\uff092024\u5e744\u670810\u65e5\uff08\u5468\u4e09\uff0900:00 – 03:30<\/li>\n<\/ul>\n

        \u6b64\u9879\u4e34\u5e8a\u524d\u7814\u7a76\u7ed3\u679c\u663e\u793a\uff0c\u65b0\u578b\u9ecf\u7740\u6591\u6fc0\u9176\uff08FAK\uff09\u6291\u5236\u5242APG-2449\u5728\u5375\u5de2\u764c\u7ec6\u80de\u4e2d\u53ef\u6291\u5236\u80bf\u7624\u7ec6\u80de\u7684\u8fc1\u79fb\u5e76\u4e14\u80fd\u591f\u534f\u540c\u589e\u5f3a\u805a\u4e59\u4e8c\u9187\u8102\u8d28\u4f53\u963f\u9709\u7d20\uff08PLD\uff09\u5728\u5375\u5de2\u764c\u5c0f\u9f20\u4e2d\u7684\u6297\u80bf\u7624\u4f5c\u7528\u3002\u7814\u7a76\u7ed3\u679c\u652f\u6301APG-2449\u8054\u5408PLD\u5728\u4e34\u5e8a\u4e0a\u6cbb\u7597\u5375\u5de2\u764c\u7684\u8fdb\u4e00\u6b65\u5f00\u53d1\u3002<\/p>\n

        \u5173\u4e8e\u4e9a\u76db\u533b\u836f<\/u><\/b><\/p>\n

        \u4e9a\u76db\u533b\u836f\u662f\u4e00\u5bb6\u7acb\u8db3\u4e2d\u56fd\u3001\u9762\u5411\u5168\u7403\u7684\u751f\u7269\u533b\u836f\u4f01\u4e1a\uff0c\u81f4\u529b\u4e8e\u5728\u80bf\u7624\u3001\u4e59\u809d\u53ca\u4e0e\u8870\u8001\u76f8\u5173\u7684\u75be\u75c5\u7b49\u6cbb\u7597\u9886\u57df\u5f00\u53d1\u521b\u65b0\u836f\u7269\u30022019\u5e7410\u670828\u65e5\uff0c\u4e9a\u76db\u533b\u836f\u5728\u9999\u6e2f\u8054\u4ea4\u6240\u4e3b\u677f\u6302\u724c\u4e0a\u5e02\uff0c\u80a1\u7968\u4ee3\u7801\uff1a6855.HK\u3002<\/p>\n

        \u4e9a\u76db\u533b\u836f\u62e5\u6709\u81ea\u4e3b\u6784\u5efa\u7684\u86cb\u767d-\u86cb\u767d\u76f8\u4e92\u4f5c\u7528\u9776\u5411\u836f\u7269\u8bbe\u8ba1\u5e73\u53f0\uff0c\u5904\u4e8e\u7ec6\u80de\u51cb\u4ea1\u901a\u8def\u65b0\u836f\u7814\u53d1\u7684\u5168\u7403\u524d\u6cbf\u3002\u516c\u53f8\u5df2\u5efa\u7acb\u62e5\u67099\u4e2a\u5df2\u8fdb\u5165\u4e34\u5e8a\u5f00\u53d1\u9636\u6bb5\u76841\u7c7b\u5c0f\u5206\u5b50\u65b0\u836f\u4ea7\u54c1\u7ba1\u7ebf\uff0c\u5305\u62ec\u6291\u5236Bcl-2\u3001IAP \u6216 MDM2-p53 \u7b49\u7ec6\u80de\u51cb\u4ea1\u901a\u8def\u5173\u952e\u86cb\u767d\u7684\u6291\u5236\u5242\uff1b\u65b0\u4e00\u4ee3\u9488\u5bf9\u764c\u75c7\u6cbb\u7597\u4e2d\u51fa\u73b0\u7684\u6fc0\u9176\u7a81\u53d8\u4f53\u7684\u6291\u5236\u5242\u7b49\uff0c\u4e3a\u5168\u7403\u552f\u4e00\u5728\u7ec6\u80de\u51cb\u4ea1\u901a\u8def\u5173\u952e\u86cb\u767d\u9886\u57df\u5747\u6709\u4e34\u5e8a\u5f00\u53d1\u54c1\u79cd\u7684\u521b\u65b0\u516c\u53f8\u3002\u76ee\u524d\u516c\u53f8\u6b63\u5728\u4e2d\u56fd\u3001\u7f8e\u56fd\u3001\u6fb3\u5927\u5229\u4e9a\u53ca\u6b27\u6d32\u5f00\u5c5540\u591a\u9879\u4e34\u5e8a\u8bd5\u9a8c\u3002<\/p>\n

        \u7528\u4e8e\u6cbb\u7597\u6162\u6027\u9ad3\u7ec6\u80de\u767d\u8840\u75c5\u7684\u6838\u5fc3\u54c1\u79cd\u5965\u96f7\u5df4\u66ff\u5c3c\uff08\u5546\u54c1\u540d\uff1a\u8010\u7acb\u514b®<\/sup>\uff09\u66fe\u83b7\u4e2d\u56fd\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u65b0\u836f\u5ba1\u8bc4\u4e2d\u5fc3\uff08CDE\uff09\u7eb3\u5165\u4f18\u5148\u5ba1\u8bc4\u548c\u7a81\u7834\u6027\u6cbb\u7597\u54c1\u79cd\uff0c\u5e76\u5df2\u5728\u4e2d\u56fd\u83b7\u6279\uff0c\u662f\u516c\u53f8\u7684\u9996\u4e2a\u4e0a\u5e02\u54c1\u79cd\u3002\u76ee\u524d\uff0c\u8010\u7acb\u514b®<\/sup>\u5df2\u88ab\u6210\u529f\u7eb3\u5165\u300a\u56fd\u5bb6\u57fa\u672c\u533b\u7597\u4fdd\u9669\u3001\u5de5\u4f24\u4fdd\u9669\u548c\u751f\u80b2\u4fdd\u9669\u836f\u54c1\u76ee\u5f55(2022\u5e74)\u300b\u3002\u8be5\u54c1\u79cd\u8fd8\u83b7\u5f97\u4e86\u7f8e\u56fdFDA\u5feb\u901f\u901a\u9053\u8d44\u683c\u3001\u5b64\u513f\u836f\u8d44\u683c\u8ba4\u5b9a\u3001\u4ee5\u53ca\u6b27\u76df\u5b64\u513f\u836f\u8d44\u683c\u8ba4\u5b9a\u3002<\/p>\n

        \u622a\u81f3\u76ee\u524d\uff0c\u516c\u53f8\u5171\u67094\u4e2a\u5728\u7814\u65b0\u836f\u83b7\u5f9716\u9879FDA\u548c1\u9879\u6b27\u76df\u5b64\u513f\u836f\u8d44\u683c\u8ba4\u5b9a\uff0c2\u9879FDA\u5feb\u901f\u901a\u9053\u8d44\u683c\u4ee5\u53ca2\u9879FDA\u513f\u7ae5\u7f55\u89c1\u75c5\u8d44\u683c\u8ba4\u8bc1\u3002\u516c\u53f8\u5148\u540e\u627f\u62c5\u591a\u9879\u56fd\u5bb6\u79d1\u6280\u91cd\u5927\u4e13\u9879\uff0c\u5176\u4e2d"\u91cd\u5927\u65b0\u836f\u521b\u5236"\u4e13\u98795\u9879\uff0c\u5305\u62ec1\u9879"\u4f01\u4e1a\u521b\u65b0\u836f\u7269\u5b75\u5316\u57fa\u5730"\u53ca4\u9879"\u521b\u65b0\u836f\u7269\u7814\u53d1"\uff0c\u53e6\u5916\u627f\u62c5"\u91cd\u5927\u4f20\u67d3\u75c5\u9632\u6cbb"\u4e13\u98791\u9879\u3002<\/p>\n

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        \u4e2d\u56fd\u82cf\u5dde\u548c\u7f8e\u56fd\u9a6c\u91cc\u5170\u5dde\u7f57\u514b\u7ef4\u5c14\u5e022024\u5e743\u67086\u65e5 \/\u7f8e\u901a\u793e\/ — \u81f4\u529b\u4e8e\u5728\u80bf\u7624\u3001\u4e59\u809d\u53ca\u4e0e\u8870\u8001\u76f8\u5173\u75be\u75c5\u7b49\u6cbb\u7597\u9886\u57df\u5f00\u53d1\u521b\u65b0\u836f\u7269\u7684\u9886\u5148\u7684\u751f\u7269\u533b\u836f\u4f01\u4e1a\u2014\u2014\u4e9a\u76db\u533b\u836f\uff086855.HK\uff09\u4eca\u65e5\u5ba3\u5e03\uff0c\u516c\u53f8\u5171\u6709\u4e09\u9879\u4e34\u5e8a\u524d\u7814\u7a76\u8fdb\u5c55\u5165\u90092024\u5e74\u7f8e\u56fd\u764c\u75c7\u7814\u7a76\u534f\u4f1a\u5e74\u4f1a\uff08AACR 2024\uff09\uff0c\u6d89\u53ca\u516c\u53f8\u539f\u521b1\u7c7b\u65b0\u836f\u5965\u96f7\u5df4\u66ff\u5c3c\uff08\u5546\u54c1\u540d\uff1a\u8010\u7acb\u514b®\uff09\u3001MDM2-p53 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\u65b0\u578b\u591a\u9776\u70b9\u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5242\u5965\u96f7\u5df4\u66ff\u5c3c\u5728SDH\u7f3a\u9677\u578b\u80bf\u7624\u4e2d\u663e\u793a\u51fa\u4f18\u5f02\u7684\u6297\u80bf\u7624\u4f5c\u7528 \u6458\u8981\u7f16\u53f7\uff1a1971 \u5206\u4f1a\u573a\u7c7b\u522b\uff1aExperimental and Molecular Therapeutics\uff08\u5b9e\u9a8c\u6027\u4e0e\u5206\u5b50\u7597\u6cd5\uff09 \u5206\u4f1a\u573a\u6807\u9898\uff1aKinase and Phosphatase Inhibitors 2\uff08\u6fc0\u9176\u548c\u78f7\u9178\u9176\u6291\u5236\u52422\uff09 \u5c55\u793a\u65f6\u95f4\uff1a\uff08\u5f53\u5730\u65f6\u95f4\uff092024\u5e744\u67088\u65e5\uff08\u5468\u4e00\uff099:00 AM – 12:30 PM\uff08\u5317\u4eac\u65f6\u95f4\uff092024\u5e744\u67089\u65e5\uff08\u5468\u4e8c\uff0900:00 – 03:30 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