{"id":105968,"date":"2024-02-22T15:52:00","date_gmt":"2024-02-22T08:52:00","guid":{"rendered":"https:\/\/www.xinwengao.com\/cn\/pr\/20240222155200105968"},"modified":"2024-02-24T22:22:05","modified_gmt":"2024-02-24T14:22:05","slug":"laura-iii-%e6%9c%9f%e4%b8%b4%e5%ba%8a%e7%a0%94%e7%a9%b6%e4%b8%ad%ef%bc%8c%e6%b3%b0%e7%91%9e%e6%b2%99%e5%af%b9%e4%ba%8eegfr-%e7%aa%81%e5%8f%98iii%e6%9c%9f%e4%b8%8d%e5%8f%af%e5%88%87%e9%99%a4%e8%82%ba","status":"publish","type":"post","link":"https:\/\/www.xinwengao.com\/cn\/pr\/20240222155200105968","title":{"rendered":"LAURA III \u671f\u4e34\u5e8a\u7814\u7a76\u4e2d\uff0c\u6cf0\u745e\u6c99\u5bf9\u4e8eEGFR \u7a81\u53d8III\u671f\u4e0d\u53ef\u5207\u9664\u80ba\u764c\u60a3\u8005\u5c55\u73b0\u51fa\u538b\u5012\u6027\u7684\u7597\u6548\u83b7\u76ca"},"content":{"rendered":"

\u9996\u4e2a\u5728\u4e0d\u53ef\u5207\uff08III\u671f\uff09\u80ba\u764c\u4e34\u5e8a\u7814\u7a76\u4e2d\u8bc1\u5b9e\u6709\u65e0\u8fdb\u5c55\u751f\u5b58\u83b7\u76ca\u9776\u5411\u6cbb\u7597\u7684EGFR\u6291\u5236\u5242<\/i><\/p>\n

\u4e0a\u6d77<\/span>2024\u5e742\u670822\u65e5<\/span> \/\u7f8e\u901a\u793e\/ — LAURA III \u671f\u4e34\u5e8a\u7814\u7a76\u9ad8\u7ea7\u522b\u7684\u9633\u6027\u7ed3\u679c\u8868\u660e\uff1a\u5728III\u671f\u4e0d\u53ef\u5207\u9664\u7684\u8868\u76ae\u751f\u957f\u56e0\u5b50\u53d7\u4f53\u7a81\u53d8\uff08EGFRm\uff09\u975e\u5c0f\u7ec6\u80de\u80ba\u764c (NSCLC) \u60a3\u8005\u4e2d\uff0c\u4e0e\u653e\u5316\u7597\u540e\u63a5\u53d7\u5b89\u6170\u5242\u7ec4\u76f8\u6bd4\uff0c\u653e\u5316\u7597\u540e\u63a5\u53d7\u963f\u65af\u5229\u5eb7\u6cf0\u745e\u6c99(\u5965\u5e0c\u66ff\u5c3c)\u7ec4\u7684\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff08PFS\uff09\u5c55\u73b0\u51fa\u7edf\u8ba1\u5b66\u548c\u4e34\u5e8a\u610f\u4e49\u7684\u6539\u5584\u3002<\/p>\n

\u5c3d\u7ba1\u5728\u672c\u6b21\u5206\u6790\u65f6\uff0c\u603b\u751f\u5b58\u671f (OS) \u6570\u636e\u5c1a\u672a\u6210\u719f\uff0c\u4f46\u6cf0\u745e\u6c99\u7ec4\u8868\u73b0\u51fa\u4e86\u79ef\u6781\u7684\u8d8b\u52bf\u3002\u8be5\u4e34\u5e8a\u7814\u7a76\u5c06\u7ee7\u7eed\u8bc4\u4f30\u6b21\u8981\u7ec8\u70b9OS\u3002<\/p>\n

\u5168\u7403\u6bcf\u5e74\u8bca\u65ad\u80ba\u764c\u7684\u603b\u4eba\u6570\u8d85\u8fc7240\u4e07\uff0c\u5176\u4e2d 80%-85%\u4e3a\u6700\u5e38\u89c1\u7684\u975e\u5c0f\u7ec6\u80de\u80ba\u764c1-3<\/sup>\u3002\u7f8e\u56fd\u548c\u6b27\u6d32\u7ea6\u670910-15\uff05\u7684\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u60a3\u8005\u5b58\u5728EGFR\u7a81\u53d8\uff08EGFRm\uff09\uff0c\u800c\u4e9a\u6d32\u60a3\u8005\u4e2d\u8be5\u6bd4\u4f8b\u9ad8\u8fbe30-40\uff054-7<\/sup>\u3002\u8d85\u8fc7\u516d\u5206\u4e4b\u4e00\uff0815%\uff09\u7684\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u60a3\u8005\u5728\u786e\u8bca\u65f6\u5df2\u4e3aIII \u671f\u4e0d\u53ef\u5207\u9664\u80ba\u764c8<\/sup>\u3002<\/p>\n

\u7f8e\u56fd\u4e9a\u7279\u5170\u5927\u57c3\u9ed8\u91cc\u5927\u5b66 Winship \u764c\u75c7\u7814\u7a76\u6240\u6267\u884c\u603b\u76d1\u3001LAURA\u7814\u7a76\u7684\u9996\u5e2d\u7814\u7a76\u8005 Suresh Ramalingam<\/span> \u533b\u5b66\u535a\u58eb\u8868\u793a\uff1a"\u8be5\u7814\u7a76\u7ed3\u679c\u5bf9\u4e8e EGFR \u7a81\u53d8\u7684III\u671f\u80ba\u764c\u60a3\u8005\uff0c\u5c24\u5176\u662f\u53ef\u80fd\u51fa\u73b0\u65e9\u671f\u8fdb\u5c55\u5e76\u4f34\u968f\u8111\u8f6c\u79fb\u5374\u65e0\u9776\u5411\u836f\u7269\u7684\u60a3\u8005\u800c\u8a00\uff0c\u662f\u4e00\u9879\u91cd\u5927\u7a81\u7834\u3002LAURA \u7814\u7a76\u8868\u660e\u5965\u5e0c\u66ff\u5c3c\u53ef\u63d0\u4f9b\u786e\u5207\u7684\u4e34\u5e8a\u83b7\u76ca\uff0c\u5e76\u53ef\u80fd\u6210\u4e3a III \u671f\u60a3\u8005\u7684\u9996\u4e2a\u9776\u5411\u6cbb\u7597\u9009\u62e9\u3002"<\/p>\n

\u963f\u65af\u5229\u5eb7\u5168\u7403\u6267\u884c\u526f\u603b\u88c1\u3001\u80bf\u7624\u7814\u53d1\u8d1f\u8d23\u4ebaSusan Galbraith\u8868\u793a\uff1a"\u9488\u5bf9\u65e9\u671f\u53ef\u80fd\u88ab\u6cbb\u6108\u7684\u80ba\u764c\uff0cLAURA \u7814\u7a76\u7ed3\u679c\u5f71\u54cd\u6df1\u8fdc\uff0c\u4e0d\u4ec5\u8fdb\u4e00\u6b65\u5de9\u56fa\u4e86\u5965\u5e0c\u66ff\u5c3c\u4f5c\u4e3a EGFR \u7a81\u53d8\u80ba\u764c\u6cbb\u7597\u7684\u57fa\u77f3\u5730\u4f4d\uff0c\u800c\u4e14\u8fde\u540cADAURA\u7684\u7814\u7a76\u7ed3\u679c\u4e00\u8d77\uff0c\u66f4\u662f\u5f3a\u8c03\u4e86\u80ba\u764c\u60a3\u8005\u5c3d\u65e9\u8bca\u65ad\u3001\u5c3d\u65e9\u6cbb\u7597\u7684\u5fc5\u8981\u6027\u3002"<\/p>\n

\u5728LAURA\u7814\u7a76\u4e2d\uff0c\u5965\u5e0c\u66ff\u5c3c\u7684\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\u4e0e\u5df2\u77e5\u7684\u5b89\u5168\u6027\u7279\u5f81\u4e00\u81f4\uff0c\u5728CRT \u540e\u63a5\u53d7\u5965\u5e0c\u66ff\u5c3c\u7ef4\u6301\u6cbb\u7597\u672a\u62a5\u544a\u65b0\u7684\u5b89\u5168\u95ee\u9898\u3002<\/p>\n

\u8fd9\u4e9b\u7814\u7a76\u6570\u636e\u5c06\u5728\u5373\u5c06\u53ec\u5f00\u7684\u533b\u5b66\u5927\u4f1a\u4e0a\u516c\u5e03\uff0c\u5e76\u4f1a\u4e0e\u5168\u7403\u536b\u751f\u76d1\u7ba1\u90e8\u95e8\u5206\u4eab\u3002<\/p>\n

\u6b64\u5916\uff0c\u57fa\u4e8eFLAURA2 III\u671f\u4e34\u5e8a\u7814\u7a76\uff0c\u6cf0\u745e\u6c99\u8054\u5408\u5316\u7597\u7684\u9002\u5e94\u75c7\u5df2\u4e8e\u8fd1\u65e5\u5728\u7f8e\u56fd\u83b7\u6279\u3002<\/p>\n

\u963f\u65af\u5229\u5eb7\u59cb\u7ec8\u79c9\u627f\u7740"\u81f4\u529b\u4e8e\u5c3d\u65e9\u6cbb\u7597\u80ba\u764c\u60a3\u8005"\u7684\u8bfa\u8a00\uff0c\u4f5c\u4e3a\u627f\u8bfa\u4e2d\u7684\u4e00\u90e8\u5206\uff0c \u8bc4\u4f30\u5965\u5e0c\u66ff\u5c3c\u65b0\u8f85\u52a9\u6cbb\u7597\u7597\u6548\u7684NeoADAURA III\u671f\u4e34\u5e8a\u7814\u7a76\u9884\u8ba1\u4f1a\u5728\u4eca\u5e74\u665a\u4e9b\u65f6\u5019\u516c\u5e03\u7814\u7a76\u7ed3\u679c\uff1b\u8bc4\u4f30\u5965\u5e0c\u66ff\u5c3c\u5728\u65e9\u671f\u53ef\u5207\u9664\u80ba\u764c\u60a3\u8005\u8f85\u52a9\u6cbb\u7597\u7597\u6548\u7684ADAURA2 III\u671f\u4e34\u5e8a\u7814\u7a76\u4e5f\u6b63\u5728\u8fdb\u884c\u4e2d\u3002<\/p>\n

\u6ce8\u91ca<\/u><\/b><\/p>\n

\u5173\u4e8e\u80ba\u764c<\/b><\/p>\n

\u80ba\u764c\u662f\u7537\u6027\u548c\u5973\u6027\u764c\u75c7\u6b7b\u4ea1\u7684\u4e3b\u8981\u539f\u56e0\uff0c\u7ea6\u5360\u6240\u6709\u764c\u75c7\u6b7b\u4ea1\u7684\u4e94\u5206\u4e4b\u4e001<\/sup>\u3002\u80ba\u764c\u5206\u4e3a\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u548c\u5c0f\u7ec6\u80de\u80ba\u764c2<\/sup>\u3002\u5927\u90e8\u5206\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u5728\u786e\u8bca\u65f6\u5df2\u662f\u665a\u671f6<\/sup>\u3002<\/p>\n

\u4f34\u6709EGFR\u7a81\u53d8\u7684\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u60a3\u8005\u5bf9\u8868\u76ae\u751f\u957f\u56e0\u5b50\u53d7\u4f53\u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5242 (EGFR-TKI) \u7684\u6cbb\u7597\u654f\u611f\uff0cEGFR-TKI \u53ef\u963b\u65ad\u9a71\u52a8\u80bf\u7624\u7ec6\u80de\u751f\u957f\u7684\u4fe1\u53f7\u901a\u8def10<\/sup>\u3002<\/p>\n

\u5173\u4e8e<\/b>LAURA<\/b>\u7814\u7a76<\/b><\/p>\n

LAURA\u662f\u4e00\u9879\u968f\u673a\u3001\u53cc\u76f2\u3001\u5b89\u6170\u5242\u5bf9\u7167\u3001\u5168\u7403\u591a\u4e2d\u5fc3\u7684III \u671f\u4e34\u5e8a\u7814\u7a76\uff0c\u53d7\u8bd5\u8005\u4e3aIII\u671f\u4e0d\u53ef\u5207\u9664\u7684EGFR\u7a81\u53d8\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff0c\u8fd9\u4e9b\u60a3\u8005\u5728\u63a5\u53d7\u4ee5\u94c2\u4e3a\u57fa\u7840\u7684\u653e\u5316\u7597\u540e\u75be\u75c5\u672a\u51fa\u73b0\u8fdb\u5c55\u3002\u60a3\u8005\u63a5\u53d7\u6bcf\u65e5\u4e00\u6b21 80 \u6beb\u514b\u5965\u5e0c\u66ff\u5c3c\u53e3\u670d\u7247\u5242\u6cbb\u7597\u76f4\u81f3\u75be\u75c5\u8fdb\u5c55\uff0c\u6216\u51fa\u73b0\u4e0d\u53ef\u8010\u53d7\u7684\u6bd2\u6027\u53cd\u5e94\u6216\u8fbe\u5230\u4e86\u505c\u836f\u6807\u51c6\u3002\u75be\u75c5\u8fdb\u5c55\u540e\uff0c\u5b89\u6170\u5242\u7ec4\u7684\u60a3\u8005\u53ef\u63a5\u53d7\u5965\u5e0c\u66ff\u5c3c\u6cbb\u7597\u3002<\/p>\n

\u8be5\u8bd5\u9a8c\u5728\u7f8e\u56fd\u3001\u6b27\u6d32\u3001\u5357\u7f8e\u6d32\u548c\u4e9a\u6d32\u7b49\u8d85\u8fc7 15 \u4e2a\u56fd\u5bb6\u7684145 \u4e2a\u4e2d\u5fc3\u5171\u62db\u52df\u4e86 216 \u540d\u60a3\u8005\u3002\u672c\u6b21\u662f\u5bf9\u4e3b\u8981\u7ec8\u70b9PFS\u8fdb\u884c\u5206\u6790\u3002\u8be5\u7814\u7a76\u6301\u7eed\u8fdb\u884c\u4e2d\uff0c\u5e76\u5c06\u7ee7\u7eed\u8bc4\u4f30\u6b21\u8981\u7ec8\u70b9 OS\u3002<\/p>\n

\u5173\u4e8e<\/b>\u5965\u5e0c\u66ff\u5c3c<\/b><\/p>\n

\u5965\u5e0c\u66ff\u5c3c\u662f\u4e00\u79cd\u4e0d\u53ef\u9006\u7684\u7b2c\u4e09\u4ee3\u8868\u76ae\u751f\u957f\u56e0\u5b50\u53d7\u4f53\u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5242\uff08EGFR-TKI\uff09\uff0c\u5728\u6cbb\u7597\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff08\u5305\u62ec\u4f34\u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf\u8f6c\u79fb\uff09\u60a3\u8005\u4e2d\u6709\u786e\u8bc1\u7684\u4e34\u5e8a\u7597\u6548\u3002\u5965\u5e0c\u66ff\u5c3c\uff0840mg \u548c 80mg \u6bcf\u65e5\u4e00\u6b21\u53e3\u670d\u7247\u5242\uff09\u5df2\u5728\u5168\u7403\u7528\u4e8e\u8fd180\u4e07\u540d\u60a3\u8005\u6cbb\u7597\u5404\u79cd\u5df2\u83b7\u6279\u9002\u5e94\u75c7\u3002\u963f\u65af\u5229\u5eb7\u5c06\u7ee7\u7eed\u63a2\u7d22\u5965\u5e0c\u66ff\u5c3c\u7528\u4e8e\u6cbb\u7597\u4e0d\u540c\u75be\u75c5\u5206\u671f\u7684EGFR\u7a81\u53d8\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u3002<\/p>\n

\u5965\u5e0c\u66ff\u5c3c\u5728\u5305\u62ec\u7f8e\u56fd\u3001\u6b27\u76df\u3001\u4e2d\u56fd\u548c\u65e5\u672c\u5728\u5185\u7684 100 \u591a\u4e2a\u56fd\u5bb6\/\u5730\u533a\u88ab\u6279\u51c6\u5355\u836f\u6cbb\u7597\u3002\u5176\u4e2d\u5305\u62ec\u7528\u4e8e\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027EGFR\u654f\u611f\u7a81\u53d8\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u4e00\u7ebf\u6cbb\u7597\u3001\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u65e2\u5f80EGFR-TKI\u6cbb\u7597\u540e\u75be\u75c5\u8fdb\u5c55\u4e14\u4f34 T790M \u7a81\u53d8\u9633\u6027\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u6cbb\u7597\uff0c\u4ee5\u53ca\u65e9\u671f\uff08IB\u3001II \u548c IIIA\uff09EGFR\u654f\u611f\u7a81\u53d8\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u7684\u672f\u540e\u8f85\u52a9\u6cbb\u7597\uff0c\u8fd1\u671f\u5965\u5e0c\u66ff\u5c3c\u8f85\u52a9\u6cbb\u7597\u7814\u7a76\u4e5f\u516c\u5e03\u4e86\u5177\u6709\u7edf\u8ba1\u5b66\u548c\u4e34\u5e8a\u610f\u4e49\u7684\u603b\u751f\u5b58\u671f\u83b7\u76ca\u3002<\/p>\n

\u5927\u91cf\u8bc1\u636e\u652f\u6301\u5965\u5e0c\u66ff\u5c3c\u5728EGFR\u7a81\u53d8\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u4e2d\u7684\u4f7f\u7528\uff0c\u4e14\u5b83\u662f\u552f\u4e00\u4e00\u4e2a\u53ef\u540c\u65f6\u6539\u5584\u65e9\u671f\uff08ADAURA III\u671f\u4e34\u5e8a\u7814\u7a76\uff09\u548c\u665a\u671f\uff08FLAURA\u548c FLAURA2 III\u671f\u4e34\u5e8a\u7814\u7a76\uff09\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u60a3\u8005\u4e34\u5e8a\u7ed3\u5c40\u7684\u9776\u5411\u7597\u6cd5\u3002<\/p>\n

\u963f\u65af\u5229\u5eb7\u8fd8\u901a\u8fc7SAVANNAH\u548cORCHARD II\u671f\u7814\u7a76\u3001SAFFRON III\u671f\u7814\u7a76\uff0c\u63a2\u7d22\u5965\u5e0c\u66ff\u5c3c\u4e0e\u8d5b\u6c83\u66ff\u5c3c\uff08\u4e00\u79cd\u53e3\u670d\u3001\u5f3a\u6548\u548c\u9ad8\u9009\u62e9\u6027MET-TKI\uff09\u8054\u5408\u7597\u6cd5\uff0c\u4ee5\u53ca\u4e0e\u5176\u4ed6\u6f5c\u5728\u65b0\u836f\u7684\u8054\u5408\u6cbb\u7597\u65b9\u6848\uff0c\u63a2\u7d22\u80bf\u7624\u7684\u8010\u836f\u673a\u5236\u3002<\/p>\n

\u5173\u4e8e\u963f\u65af\u5229\u5eb7\u5728\u80ba\u764c\u9886\u57df\u7684\u4ea7\u54c1\u7ba1\u7ebf<\/b><\/p>\n

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\u963f\u65af\u5229\u5eb7\u662f\u5168\u7403Lung Ambition Alliance\u7684\u521b\u59cb\u6210\u5458\uff0c\u8be5\u5168\u7403\u6027\u8054\u76df\u81f4\u529b\u4e8e\u52a0\u5feb\u521b\u65b0\u6b65\u4f10\uff0c\u5e76\u4e3a\u80ba\u764c\u60a3\u8005\u63d0\u4f9b\u5305\u62ec\u6cbb\u7597\u548c\u6cbb\u7597\u4ee5\u5916\u5177\u6709\u610f\u4e49\u7684\u6539\u5584\u63aa\u65bd\u3002<\/p>\n

\u5173\u4e8e\u963f\u65af\u5229\u5eb7\u5728\u80bf\u7624\u9886\u57df\u7684\u613f\u666f<\/b><\/p>\n

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\u963f\u65af\u5229\u5eb7\u7684\u4e13\u6ce8\u4e8e\u6700\u5177\u6311\u6218\u6027\u7684\u80bf\u7624\u75be\u75c5\uff0c\u901a\u8fc7\u6301\u7eed\u4e0d\u65ad\u7684\u521b\u65b0\uff0c\u963f\u65af\u5229\u5eb7\u5df2\u7ecf\u5efa\u7acb\u4e86\u9886\u5148\u5168\u884c\u4e1a\u7684\u591a\u5143\u5316\u4ea7\u54c1\u7ec4\u5408\u548c\u4ea7\u54c1\u7ba1\u7ebf\uff0c\u6301\u7eed\u63a8\u52a8\u533b\u7597\u5b9e\u8df5\u53d8\u9769\uff0c\u6539\u5584\u60a3\u8005\u4f53\u9a8c\u3002<\/p>\n

\u963f\u65af\u5229\u5eb7\u7684\u613f\u666f\u65e8\u5728\u91cd\u65b0\u5b9a\u4e49\u764c\u75c7\u6cbb\u7597\uff0c\u4ee5\u671f\u672a\u6765\u7ec8\u7ed3\u764c\u75c7\u8fd9\u4e00\u81f4\u6b7b\u4e4b\u56e0\u3002<\/p>\n

\u58f0\u660e\uff1a\u672c\u6587\u6d89\u53ca\u672a\u5728\u4e2d\u56fd\u83b7\u6279\u7684\u4ea7\u54c1\u6216\u8005\u9002\u5e94\u75c7\uff0c\u963f\u65af\u5229\u5eb7\u4e0d\u63a8\u8350\u4efb\u4f55\u672a\u88ab\u6279\u836f\u54c1<\/i>\/<\/i>\u9002\u5e94\u75c7\u7684\u4f7f\u7528\u3002<\/i><\/p>\n

References \u53c2\u8003\u6587\u732e<\/p>\n

    \n
  1. World Health Organisation. International Agency for Research on Cancer. Lung Fact Sheet. Available at: https:\/\/gco.iarc.who.int\/media\/globocan\/factsheets\/cancers\/15-trachea-bronchus-and-lung-fact-sheet.pdf<\/a>. Accessed February 2024.  <\/li>\n
  2. LUNGevity Foundation. Types of Lung Cancer. Available at: https:\/\/lungevity.org\/for-patients-caregivers\/lung-cancer-101\/types-of-lung-cancer<\/a>. Accessed February 2024. <\/li>\n
  3. American Cancer Society. What Is Lung Cancer? Available at: https:\/\/www.cancer.org\/cancer\/lung-cancer\/about\/what-is.html#:~:text=About%2080%25%20to%2085%25%20of,(outlook)%20are%20often%20similar<\/a>. Accessed February 2024.\u202f\u202f<\/li>\n
  4. Knight SB, et al. Progress and prospects of early detection in lung cancer. Open Biol. 2017;7(9): 170070.<\/li>\n
  5. Keedy VL, et al. American Society of Clinical Oncology Provisional Clinical Opinion: Epidermal Growth Factor Receptor (EGFR) Mutation Testing for Patients with Advanced Non-Small-Cell Lung Cancer Considering First-Line EGFR Tyrosine Kinase Inhibitor Therapy. J Clin Oncol. 2011:29;2121-27.<\/li>\n
  6. Zhang Y, et al. The prevalence of EGFR mutation in patients with non-small cell lung cancer: a systematic review and meta-analysis. Oncotarget. 2016;7(48).<\/li>\n
  7. Szumera-Cie\u0107kiewicz A, et al.\u202fEGFR Mutation Testing on Cytological and Histological Samples in 11. Non-Small Cell Lung Cancer: a Polish, Single Institution Study and Systematic Review of European Incidence.\u202fInt J Clin Exp Pathol. 2013:6;2800-12.\u202f<\/li>\n
  8. Cerner CancerMPact database.Accessed October 2023<\/span>.<\/li>\n
  9. Keedy VL, et al<\/i>. American Society of Clinical Oncology Provisional Clinical Opinion: Epidermal Growth Factor Receptor (EGFR) Mutation Testing for Patients with Advanced Non-Small-Cell Lung Cancer Considering First-Line EGFR Tyrosine Kinase Inhibitor Therapy. J Clin Oncol<\/i>. 2011:29;2121-27.<\/li>\n
  10. Ellison G, et al<\/i>. EGFR Mutation Testing in Lung Cancer: a Review of Available Methods and Their Use for Analysis of Tumour Tissue and Cytology Samples. J Clin Pathol<\/i>. 2013:66;79-89.<\/li>\n
  11. Cross DA, et al<\/i>. AZD9291, an Irreversible EGFR TKI, Overcomes T790M-Mediated Resistance to EGFR Inhibitors in Lung Cancer. Cancer Discov<\/i>. 2014;4(9):1046-1061.<\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"

    \u9996\u4e2a\u5728\u4e0d\u53ef\u5207\uff08III\u671f\uff09\u80ba\u764c\u4e34\u5e8a\u7814\u7a76\u4e2d\u8bc1\u5b9e\u6709\u65e0\u8fdb\u5c55\u751f\u5b58\u83b7\u76ca\u9776\u5411\u6cbb\u7597\u7684EGFR\u6291\u5236\u5242 \u4e0a\u6d772024\u5e742\u670822\u65e5 \/\u7f8e\u901a\u793e\/ — LAURA III \u671f\u4e34\u5e8a\u7814\u7a76\u9ad8\u7ea7\u522b\u7684\u9633\u6027\u7ed3\u679c\u8868\u660e\uff1a\u5728III\u671f\u4e0d\u53ef\u5207\u9664\u7684\u8868\u76ae\u751f\u957f\u56e0\u5b50\u53d7\u4f53\u7a81\u53d8\uff08EGFRm\uff09\u975e\u5c0f\u7ec6\u80de\u80ba\u764c (NSCLC) \u60a3\u8005\u4e2d\uff0c\u4e0e\u653e\u5316\u7597\u540e\u63a5\u53d7\u5b89\u6170\u5242\u7ec4\u76f8\u6bd4\uff0c\u653e\u5316\u7597\u540e\u63a5\u53d7\u963f\u65af\u5229\u5eb7\u6cf0\u745e\u6c99(\u5965\u5e0c\u66ff\u5c3c)\u7ec4\u7684\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff08PFS\uff09\u5c55\u73b0\u51fa\u7edf\u8ba1\u5b66\u548c\u4e34\u5e8a\u610f\u4e49\u7684\u6539\u5584\u3002 \u5c3d\u7ba1\u5728\u672c\u6b21\u5206\u6790\u65f6\uff0c\u603b\u751f\u5b58\u671f (OS) \u6570\u636e\u5c1a\u672a\u6210\u719f\uff0c\u4f46\u6cf0\u745e\u6c99\u7ec4\u8868\u73b0\u51fa\u4e86\u79ef\u6781\u7684\u8d8b\u52bf\u3002\u8be5\u4e34\u5e8a\u7814\u7a76\u5c06\u7ee7\u7eed\u8bc4\u4f30\u6b21\u8981\u7ec8\u70b9OS\u3002 \u5168\u7403\u6bcf\u5e74\u8bca\u65ad\u80ba\u764c\u7684\u603b\u4eba\u6570\u8d85\u8fc7240\u4e07\uff0c\u5176\u4e2d 80%-85%\u4e3a\u6700\u5e38\u89c1\u7684\u975e\u5c0f\u7ec6\u80de\u80ba\u764c1-3\u3002\u7f8e\u56fd\u548c\u6b27\u6d32\u7ea6\u670910-15\uff05\u7684\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u60a3\u8005\u5b58\u5728EGFR\u7a81\u53d8\uff08EGFRm\uff09\uff0c\u800c\u4e9a\u6d32\u60a3\u8005\u4e2d\u8be5\u6bd4\u4f8b\u9ad8\u8fbe30-40\uff054-7\u3002\u8d85\u8fc7\u516d\u5206\u4e4b\u4e00\uff0815%\uff09\u7684\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u60a3\u8005\u5728\u786e\u8bca\u65f6\u5df2\u4e3aIII \u671f\u4e0d\u53ef\u5207\u9664\u80ba\u764c8\u3002 \u7f8e\u56fd\u4e9a\u7279\u5170\u5927\u57c3\u9ed8\u91cc\u5927\u5b66 Winship \u764c\u75c7\u7814\u7a76\u6240\u6267\u884c\u603b\u76d1\u3001LAURA\u7814\u7a76\u7684\u9996\u5e2d\u7814\u7a76\u8005 Suresh Ramalingam \u533b\u5b66\u535a\u58eb\u8868\u793a\uff1a"\u8be5\u7814\u7a76\u7ed3\u679c\u5bf9\u4e8e EGFR \u7a81\u53d8\u7684III\u671f\u80ba\u764c\u60a3\u8005\uff0c\u5c24\u5176\u662f\u53ef\u80fd\u51fa\u73b0\u65e9\u671f\u8fdb\u5c55\u5e76\u4f34\u968f\u8111\u8f6c\u79fb\u5374\u65e0\u9776\u5411\u836f\u7269\u7684\u60a3\u8005\u800c\u8a00\uff0c\u662f\u4e00\u9879\u91cd\u5927\u7a81\u7834\u3002LAURA \u7814\u7a76\u8868\u660e\u5965\u5e0c\u66ff\u5c3c\u53ef\u63d0\u4f9b\u786e\u5207\u7684\u4e34\u5e8a\u83b7\u76ca\uff0c\u5e76\u53ef\u80fd\u6210\u4e3a III \u671f\u60a3\u8005\u7684\u9996\u4e2a\u9776\u5411\u6cbb\u7597\u9009\u62e9\u3002" \u963f\u65af\u5229\u5eb7\u5168\u7403\u6267\u884c\u526f\u603b\u88c1\u3001\u80bf\u7624\u7814\u53d1\u8d1f\u8d23\u4ebaSusan Galbraith\u8868\u793a\uff1a"\u9488\u5bf9\u65e9\u671f\u53ef\u80fd\u88ab\u6cbb\u6108\u7684\u80ba\u764c\uff0cLAURA \u7814\u7a76\u7ed3\u679c\u5f71\u54cd\u6df1\u8fdc\uff0c\u4e0d\u4ec5\u8fdb\u4e00\u6b65\u5de9\u56fa\u4e86\u5965\u5e0c\u66ff\u5c3c\u4f5c\u4e3a EGFR \u7a81\u53d8\u80ba\u764c\u6cbb\u7597\u7684\u57fa\u77f3\u5730\u4f4d\uff0c\u800c\u4e14\u8fde\u540cADAURA\u7684\u7814\u7a76\u7ed3\u679c\u4e00\u8d77\uff0c\u66f4\u662f\u5f3a\u8c03\u4e86\u80ba\u764c\u60a3\u8005\u5c3d\u65e9\u8bca\u65ad\u3001\u5c3d\u65e9\u6cbb\u7597\u7684\u5fc5\u8981\u6027\u3002" \u5728LAURA\u7814\u7a76\u4e2d\uff0c\u5965\u5e0c\u66ff\u5c3c\u7684\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\u4e0e\u5df2\u77e5\u7684\u5b89\u5168\u6027\u7279\u5f81\u4e00\u81f4\uff0c\u5728CRT \u540e\u63a5\u53d7\u5965\u5e0c\u66ff\u5c3c\u7ef4\u6301\u6cbb\u7597\u672a\u62a5\u544a\u65b0\u7684\u5b89\u5168\u95ee\u9898\u3002 \u8fd9\u4e9b\u7814\u7a76\u6570\u636e\u5c06\u5728\u5373\u5c06\u53ec\u5f00\u7684\u533b\u5b66\u5927\u4f1a\u4e0a\u516c\u5e03\uff0c\u5e76\u4f1a\u4e0e\u5168\u7403\u536b\u751f\u76d1\u7ba1\u90e8\u95e8\u5206\u4eab\u3002 \u6b64\u5916\uff0c\u57fa\u4e8eFLAURA2 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