{"id":105910,"date":"2024-02-22T15:41:00","date_gmt":"2024-02-22T08:41:00","guid":{"rendered":"https:\/\/www.xinwengao.com\/cn\/pr\/20240222154100105910"},"modified":"2024-02-24T22:18:55","modified_gmt":"2024-02-24T14:18:55","slug":"%e6%b3%b0%e7%91%9e%e6%b2%99%e8%81%94%e5%90%88%e5%8c%96%e7%96%97%e5%9c%a8%e7%be%8e%e5%9b%bd%e8%8e%b7%e6%89%b9%e7%94%a8%e4%ba%8e%e6%b2%bb%e7%96%97egfr%e7%aa%81%e5%8f%98%e6%99%9a%e6%9c%9f%e8%82%ba","status":"publish","type":"post","link":"https:\/\/www.xinwengao.com\/cn\/pr\/20240222154100105910","title":{"rendered":"\u6cf0\u745e\u6c99\u8054\u5408\u5316\u7597\u5728\u7f8e\u56fd\u83b7\u6279\u7528\u4e8e\u6cbb\u7597EGFR\u7a81\u53d8\u665a\u671f\u80ba\u764c\u60a3\u8005"},"content":{"rendered":"

\u6b64\u6b21\u83b7\u6279\u57fa\u4e8e<\/i><\/b>FLAURA2<\/i><\/b>\u7814\u7a76\uff1a\u4e0e\u4e00\u7ebf\u6807\u51c6\u6cbb\u7597\u65b9\u6848\u76f8\u6bd4\uff0c\u6cf0\u745e\u6c99\u8054\u5408\u5316\u7597\u53ef\u5ef6\u957f\u4e2d\u4f4d\u751f\u5b58\u671f\u8fd1<\/i><\/b>9<\/i><\/b>\u4e2a\u6708<\/i><\/b><\/p>\n

\u4e0a\u6d77<\/span>2024\u5e742\u670822\u65e5<\/span> \/\u7f8e\u901a\u793e\/ — \u963f\u65af\u5229\u5eb7\u6cf0\u745e\u6c99\uff08\u5965\u5e0c\u66ff\u5c3c\uff09\u8054\u5408\u5316\u7597\u5728\u7f8e\u56fd\u83b7\u6279\uff0c\u7528\u4e8e\u6cbb\u7597\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u8868\u76ae\u751f\u957f\u56e0\u5b50\u53d7\u4f53\u7a81\u53d8 (EGFRm) \u975e\u5c0f\u7ec6\u80de\u80ba\u764c (NSCLC) \u60a3\u8005\u3002<\/p>\n

\u6b64\u6b21\u5728\u7f8e\u56fd\u98df\u54c1\u548c\u836f\u7269\u7ba1\u7406\u5c40\uff08FDA\uff09\u4f18\u5148\u5ba1\u8bc4\u7684\u57fa\u7840\u4e0a\u83b7\u6279\u662f\u57fa\u4e8e\u53d1\u8868\u5728\u300a\u65b0\u82f1\u683c\u5170\u533b\u5b66\u6742\u5fd7\u300b\u7684 FLAURA2 III \u671f\u7814\u7a76\u7ed3\u679c\u3002\u4e0e\u5168\u7403\u4e00\u7ebf\u6807\u51c6\u6cbb\u7597\u65b9\u6848\u5965\u5e0c\u66ff\u5c3c\u5355\u836f\u6cbb\u7597\u76f8\u6bd4\uff0c\u5965\u5e0c\u66ff\u5c3c\u8054\u5408\u5316\u7597\u5c06\u75be\u75c5\u8fdb\u5c55\u6216\u6b7b\u4ea1\u98ce\u9669\u964d\u4f4e\u4e8638%\uff08\u98ce\u9669\u6bd4[HR]\uff1a0.62; 95%\u7f6e\u4fe1\u533a\u95f4[CI] 0.49-0.79; p<0.0001\uff09\u3002\u7531\u7814\u7a76\u8005\u8bc4\u4f30\u7684\u7ed3\u679c\u663e\u793a\uff0c\u4e0e\u5965\u5e0c\u66ff\u5c3c\u5355\u836f\u6cbb\u7597\u76f8\u6bd4\uff0c\u5965\u5e0c\u66ff\u5c3c\u8054\u5408\u5316\u7597\u4f7f\u5f97\u60a3\u8005\u7684\u4e2d\u4f4d\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff08PFS\uff09\u8fbe25.5\u4e2a\u6708\uff0c\u76f8\u8f83\u4e8e\u5965\u5e0c\u66ff\u5c3c\u5355\u836f\u6cbb\u7597\uff08\u4e2d\u4f4dPFS\u4e3a16.7\u4e2a\u6708\uff09\uff0c\u5ef6\u957f\u4e868.8\u4e2a\u6708\u3002<\/p>\n

\u8fd9\u4e0e\u7531\u76f2\u6001\u72ec\u7acb\u4e2d\u592e\u5ba1\u67e5\u7ec4\uff08BICR\uff09\u8bc4\u4f30\u7684PFS\u7ed3\u679c\u4e00\u81f4\uff1a\u5965\u5e0c\u66ff\u5c3c\u8054\u5408\u5316\u7597\u4f7f\u5f97\u60a3\u8005\u7684\u4e2d\u4f4d\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff08PFS\uff09\u8fbe29.4\u4e2a\u6708\uff0c\u76f8\u8f83\u4e8e\u5965\u5e0c\u66ff\u5c3c\u5355\u836f\u6cbb\u7597\uff08\u4e2d\u4f4dPFS\u4e3a19.9\u4e2a\u6708\uff09\uff0c\u5c06\u60a3\u8005\u7684\u4e2d\u4f4dPFS\u5ef6\u957f\u4e869.5\u4e2a\u6708\uff08HR\uff1a0.62; 95% CI 0.48-0.80; p=0.0002\uff09\u3002<\/p>\n

\u5728\u7f8e\u56fd\uff0c\u6bcf\u5e74\u88ab\u8bca\u65ad\u4e3a\u80ba\u764c\u7684\u4eba\u6570\u8d85\u8fc720\u4e07\uff0c\u5176\u4e2d 80%-85%\u4e3a\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff0c\u8fd9\u662f\u6700\u5e38\u89c1\u7684\u80ba\u764c\u7c7b\u578b[1-3]<\/sup>\u3002\u7ea6\u670970%\u7684\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u5728\u786e\u8bca\u65f6\u5df2\u662f\u665a\u671f[4]<\/sup>\u3002\u6b64\u5916\uff0c\u7f8e\u56fd\u7ea6\u670915%\u7684\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u60a3\u8005\u4f34\u6709EGFR\u7a81\u53d8[5]<\/sup>\u3002<\/p>\n

\u7f8e\u56fd\u4e39\u5a1c-\u6cd5\u4f2f\u764c\u75c7\u7814\u7a76\u9662\u80bf\u7624\u5185\u79d1\u4e13\u5bb6\u3001FLAURA2 \u7814\u7a76\u7684\u9996\u5e2d\u7814\u7a76\u8005Pasi A. Jänne \u533b\u5b66\u535a\u58eb\u8868\u793a\uff1a"\u6b64\u6b21\u83b7\u6279\u57fa\u4e8eFLAURA2\u53f2\u65e0\u524d\u4f8b\u7684\u7814\u7a76\u7ed3\u679c\uff0c\u8fd9\u4e3a\u665a\u671f EGFR \u7a81\u53d8\u7684\u60a3\u8005\u5e26\u6765\u4e86\u5173\u952e\u7684\u65b0\u6cbb\u7597\u9009\u62e9\u3002\u5982\u4eca\uff0c\u6709\u4e86\u8fd9\u4e24\u79cd\u57fa\u4e8e\u5965\u5e0c\u66ff\u5c3c\u7684\u9ad8\u6548\u6cbb\u7597\u65b9\u6848\uff0c\u533b\u751f\u53ef\u4ee5\u66f4\u597d\u5730\u6839\u636e\u4e2a\u4eba\u9700\u6c42\u6765\u5236\u5b9a\u6cbb\u7597\u65b9\u6848\uff0c\u786e\u4fdd\u6bcf\u4e00\u4f4d\u60a3\u8005\u83b7\u5f97\u6700\u4f73\u6cbb\u7597\u6548\u679c\u3002"<\/p>\n

\u963f\u65af\u5229\u5eb7\u5168\u7403\u6267\u884c\u526f\u603b\u88c1\u3001\u80bf\u7624\u4e1a\u52a1\u8d1f\u8d23\u4ebaDave Fredrickson\u8868\u793a\uff1a"\u8fd9\u4e2a\u81f3\u5173\u91cd\u8981\u7684\u6cbb\u7597\u65b9\u6848\u53ef\u5ef6\u7f13\u75be\u75c5\u8fdb\u5c55\u8fd1\u4e5d\u4e2a\u6708\uff0c\u4e0d\u4ec5\u5728\u665a\u671f\u80ba\u764c\u7684\u4e00\u7ebf\u6cbb\u7597\u4e2d\u6811\u7acb\u4e86\u65b0\u6807\u51c6\uff0c\u4e5f\u662f\u76ee\u524d\u6700\u957f\u7684\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\u83b7\u76ca\u3002\u6b64\u6b21\u83b7\u6279\u5de9\u56fa\u4e86\u5965\u5e0c\u66ff\u5c3c\u6cbb\u7597EGFR \u7a81\u53d8\u80ba\u764c\u7684\u57fa\u77f3\u5730\u4f4d\uff0c\u65e0\u8bba\u662f\u5355\u836f\u6cbb\u7597\u8fd8\u662f\u8054\u5408\u5316\u7597\u3002\u8fd9\u5bf9\u9884\u540e\u8f83\u5dee\uff0c\u5305\u62ec\u4f34\u6709\u8111\u8f6c\u79fb\u548cL858R \u7a81\u53d8\u7684\u80ba\u764c\u60a3\u8005\u4e5f\u5c24\u4e3a\u91cd\u8981\u3002"<\/p>\n

GO2\u80ba\u764c\u57fa\u91d1\u4f1a\u7684\u603b\u88c1\u517cCEO Laurie Ambrose\u8868\u793a\uff1a"\u770b\u5230\u8fd9\u4e00\u6301\u7eed\u8fdb\u5c55\u5c06\u4e3a\u6211\u4eec\u7684\u793e\u533a\u63d0\u4f9b\u66f4\u591a\u4e2a\u6027\u5316\u7684\u6cbb\u7597\u65b9\u6848\uff0c\u6211\u975e\u5e38\u6fc0\u52a8\u3002\u6211\u4eec\u7684\u5171\u540c\u613f\u666f\u662f\uff1a\u5728\u6b63\u786e\u7684\u65f6\u95f4\u628a\u6b63\u786e\u7684\u8bca\u7597\u5e26\u7ed9\u6b63\u786e\u7684\u60a3\u8005\uff0c\u8ba9\u6211\u4eec\u7684\u793e\u533a\u6210\u5458\u5f97\u5230\u66f4\u597d\u7684\u751f\u5b58\u83b7\u76ca\u3002"<\/p>\n

FLAURA2 \u7814\u7a76\u4e2d\u5bf9\u57fa\u7ebf\u4f34\u6709\u8111\u8f6c\u79fb\u7684\u60a3\u8005\u8fdb\u884c\u9884\u5148\u8bbe\u5b9a\u63a2\u7d22\u6027\u5206\u6790\u7ed3\u679c\u663e\u793a\uff1a\u4e0e\u5965\u5e0c\u66ff\u5c3c\u5355\u836f\u6cbb\u7597\u76f8\u6bd4\uff0c\u5965\u5e0c\u66ff\u5c3c\u8054\u5408\u5316\u7597\u5c06\u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf (CNS) \u75be\u75c5\u8fdb\u5c55\u6216\u6b7b\u4ea1\u7684\u98ce\u9669\u964d\u4f4e \u4e8642%\uff08HR 0.58\uff1b95% CI 0.33 -1.01) \uff0c\u8be5\u7814\u7a76\u7ed3\u679c\u7531BICR\u8bc4\u4f30\u3002\u7ecf\u8fc7\u4e24\u5e74\u7684\u968f\u8bbf\uff0c\u63a5\u53d7\u5965\u5e0c\u66ff\u5c3c\u8054\u5408\u5316\u7597\u7684\u60a3\u8005\u4e2d\uff0c\u6709 74% \u7684\u60a3\u8005\u672a\u51fa\u73b0\u9885\u5185\u8fdb\u5c55\uff0c\u800c\u63a5\u53d7\u5965\u5e0c\u66ff\u5c3c\u5355\u836f\u7684\u60a3\u8005\u4e2d\u4e3a 54%\u3002<\/p>\n

\u867d\u7136\u603b\u751f\u5b58\u671f (OS) \u6570\u636e\u5728\u7b2c\u4e8c\u6b21\u4e2d\u671f\u5206\u6790\u65f6\uff0c\u5c1a\u672a\u6210\u719f\uff08\u6210\u719f\u5ea6\u4e3a 41%\uff09\uff0c\u4f46\u6ca1\u6709\u89c2\u5bdf\u5230\u635f\u5bb3\u8d8b\u52bf\uff08HR 0.75\uff1b95% CI 0.57-0.97\uff09\u3002\u8be5\u7814\u7a76\u5c06\u7ee7\u7eed\u628aOS\u4f5c\u4e3a\u5173\u952e\u6b21\u8981\u7ec8\u70b9\u3002<\/p>\n

\u5965\u5e0c\u66ff\u5c3c\u8054\u5408\u5316\u7597\u7684\u5b89\u5168\u6027\u603b\u4f53\u53ef\u7ba1\u7406\uff0c\u5e76\u4e14\u4e0e\u6bcf\u79cd\u836f\u7269\u7684\u5df2\u77e5\u7684\u5b89\u5168\u6027\u7279\u5f81\u4e00\u81f4\u3002\u5965\u5e0c\u66ff\u5c3c\u8054\u5408\u5316\u7597\u7ec4\u7684\u4e0d\u826f\u4e8b\u4ef6 (AE) \u53d1\u751f\u7387\u8f83\u9ad8\uff0c\u8fd9\u662f\u7531\u4e8e\u5316\u7597\u5f15\u8d77\u7684AE\u3002\u4e24\u4e2a\u8bd5\u9a8c\u7ec4\u4e2d\uff0c\u7531\u4e8eAE\u5bfc\u81f4\u7684\u5965\u5e0c\u66ff\u5c3c\u505c\u836f\u7387\u90fd\u5f88\u4f4e\uff08\u5965\u5e0c\u66ff\u5c3c\u8054\u5408\u5316\u7597\u4e3a 11%\uff0c\u5965\u5e0c\u66ff\u5c3c\u5355\u836f\u6cbb\u7597\u4e3a 6%\uff09\u3002<\/p>\n

2023\u5e7412\u6708\uff0c\u57fa\u4e8eFLAURA2\u7814\u7a76\uff0c\u5965\u5e0c\u66ff\u5c3c\u8054\u5408\u5316\u7597\u4f5c\u4e3a1\u7c7b\u63a8\u8350\u4e2d"\u5176\u4ed6\u63a8\u8350\u65b9\u6848"\uff0c\u88ab\u7eb3\u5165\u300aNCCN\u4e34\u5e8a\u5b9e\u8df5\u6307\u5357\u300b\uff08NCCN Guidelines®\uff09\uff0c\u7528\u4e8e\u6cbb\u7597\u4f34\u6709EGFR Exon 19 Del\/Exon 21 L858R\u7a81\u53d8\u7684\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u60a3\u8005[6]<\/sup>\u3002<\/p>\n

\u7f8e\u56fd\u6ce8\u518c\u7533\u8bf7\u6587\u4ef6\u6b63\u5904\u4e8eOrbis\u9879\u76ee\u7684\u5ba1\u67e5\u4e2d\uff0c\u8be5\u9879\u76ee\u65e8\u5728\u4e3a\u76d1\u7ba1\u673a\u6784\u63d0\u4f9b\u4e00\u4e2a\u9488\u5bf9\u80bf\u7624\u836f\u7269\u7684\u5171\u540c\u63d0\u4ea4\u548c\u5ba1\u6279\u7684\u534f\u4f5c\u6846\u67b6\u3002\u4f5c\u4e3a\u9879\u76ee\u4e2d\u7684\u4e00\u90e8\u5206\uff0c\u5965\u5e0c\u66ff\u5c3c\u8054\u5408\u5316\u7597\u4e5f\u6b63\u5728\u63a5\u53d7\u6fb3\u5927\u5229\u4e9a\u3001\u52a0\u62ff\u5927\u548c\u745e\u58eb\u76d1\u7ba1\u673a\u6784\u7684\u5ba1\u67e5\u3002\u4e0e\u6b64\u540c\u65f6\uff0c\u57fa\u4e8eFLAURA2\u7814\u7a76\u7ed3\u679c\u7684\u6ce8\u518c\u7533\u8bf7\u4e5f\u6b63\u5728\u63a5\u53d7\u5176\u4ed6\u51e0\u4e2a\u56fd\u5bb6\u7684\u8bc4\u5ba1\u3002<\/p>\n

\u5965\u5e0c\u66ff\u5c3c\u5df2\u5728\u5305\u62ec\u7f8e\u56fd\u3001\u6b27\u76df\u3001\u4e2d\u56fd\u548c\u65e5\u672c\u5728\u5185\u7684100\u591a\u4e2a\u56fd\u5bb6\u88ab\u6279\u51c6\u7528\u4f5c\u5355\u836f\u6cbb\u7597\uff0c\u5305\u62ec\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027EGFR\u7a81\u53d8\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u60a3\u8005\u7684\u4e00\u7ebf\u6cbb\u7597\u3001\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027EGFR T790M\u7a81\u53d8\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u60a3\u8005\u7684\u6cbb\u7597\u4ee5\u53ca\u65e9\u671fEGFR\u7a81\u53d8\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u60a3\u8005\u7684\u8f85\u52a9\u6cbb\u7597\u3002<\/p>\n

\u963f\u65af\u5229\u5eb7\u59cb\u7ec8\u79c9\u627f\u7740"\u81f4\u529b\u4e8e\u5c3d\u65e9\u6cbb\u7597\u80ba\u764c\u60a3\u8005"\u7684\u627f\u8bfa\uff0c\u4f5c\u4e3a\u627f\u8bfa\u4e2d\u7684\u4e00\u90e8\u5206\uff0c \u8bc4\u4f30\u5965\u5e0c\u66ff\u5c3c\u65b0\u8f85\u52a9\u6cbb\u7597\u7597\u6548\u7684NeoADAURA III\u671f\u4e34\u5e8a\u7814\u7a76\u9884\u8ba1\u4eca\u5e74\u665a\u4e9b\u65f6\u5019\u53d6\u5f97\u7ed3\u679c\uff1b\u8bc4\u4f30\u5965\u5e0c\u66ff\u5c3c\u5728\u65e9\u671f\u53ef\u5207\u9664\u60a3\u8005\u8f85\u52a9\u6cbb\u7597\u7597\u6548\u7684ADAURA2 III\u671f\u4e34\u5e8a\u7814\u7a76\u4e5f\u6b63\u5728\u8fdb\u884c\u4e2d\u3002<\/p>\n

Notes<\/b><\/p>\n

\u5173\u4e8e\u80ba\u764c<\/b><\/p>\n

\u80ba\u764c\u662f\u7537\u6027\u548c\u5973\u6027\u764c\u75c7\u6b7b\u4ea1\u7684\u4e3b\u8981\u539f\u56e0\uff0c\u7ea6\u5360\u6240\u6709\u764c\u75c7\u6b7b\u4ea1\u7684\u4e94\u5206\u4e4b\u4e00[7]<\/sup>\u3002\u80ba\u764c\u5206\u4e3a\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u548c\u5c0f\u7ec6\u80de\u80ba\u764c[2]<\/sup>\u3002\u5927\u90e8\u5206\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u5728\u786e\u8bca\u65f6\u5df2\u662f\u665a\u671f[4]<\/sup>\u3002<\/p>\n

\u4f34\u6709EGFR\u7a81\u53d8\u7684\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u60a3\u8005\u5bf9\u8868\u76ae\u751f\u957f\u56e0\u5b50\u53d7\u4f53\u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5242 (EGFR-TKI) \u7684\u6cbb\u7597\u654f\u611f\uff0cEGFR-TKI \u53ef\u963b\u65ad\u9a71\u52a8\u80bf\u7624\u7ec6\u80de\u751f\u957f\u7684\u7ec6\u80de\u4fe1\u53f7\u901a\u8def[8]<\/sup>\u3002<\/p>\n

\u5173\u4e8e<\/b>FLAURA2<\/b>\u7814\u7a76<\/b><\/p>\n

FLAURA2\u662f\u4e00\u9879\u968f\u673a\u5bf9\u7167\u3001\u5f00\u653e\u6807\u7b7e\u3001\u5168\u7403\u591a\u4e2d\u5fc3\u7684III\u671f\u8bd5\u9a8c\uff0c\u5bf9\u5c40\u90e8\u665a\u671f\uff08IIIB-IIIC\u671f\uff09\u6216\u8f6c\u79fb\u6027\uff08IV\u671f\uff09EGFR\u7a81\u53d8\u7684\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u60a3\u8005\u8fdb\u884c\u4e00\u7ebf\u6cbb\u7597\u3002\u5b9e\u9a8c\u7ec4\u60a3\u8005\u63a5\u53d7\u5965\u5e0c\u66ff\u5c3c 80mg \u6bcf\u65e5\u4e00\u6b21\u53e3\u670d\u7247\u5242\u8054\u5408\u5316\u7597\uff08\u57f9\u7f8e\u66f2\u585e (500mg\/m2) \u52a0\u987a\u94c2 (75mg\/m2) \u6216\u5361\u94c2 (AUC5)\uff09\uff0c\u6bcf\u4e09\u5468\u4e00\u6b21\uff0c\u6301\u7eed\u56db\u4e2a\u5468\u671f\uff0c\u968f\u540e\u6bcf\u4e09\u5468\u63a5\u53d7\u4e00\u6b21\u5965\u5e0c\u66ff\u5c3c\u8054\u5408\u57f9\u7f8e\u66f2\u585e\u7ef4\u6301\u6cbb\u7597\u3002<\/p>\n

\u8be5\u7814\u7a76\u5171\u5165\u7ec4557\u4f8b\u60a3\u8005\uff0c\u5728\u5168\u7403150\u591a\u4e2a\u4e2d\u5fc3\u5f00\u5c55\uff0c\u5305\u62ec\u7f8e\u56fd\u3001\u6b27\u6d32\u3001\u5357\u7f8e\u548c\u4e9a\u6d32\u5728\u5185\u768420\u591a\u4e2a\u56fd\u5bb6\uff0c\u6b64\u6b21\u662f\u9488\u5bf9\u4e3b\u8981\u7814\u7a76\u7ec8\u70b9PFS\u7684\u5206\u6790\u3002\u8be5\u7814\u7a76\u4ecd\u5728\u8fdb\u884c\u4e2d\uff0c\u540e\u7eed\u5c06\u7ee7\u7eed\u8bc4\u4f30\u6b21\u8981\u7ec8\u70b9OS\u3002<\/p>\n

\u5173\u4e8e\u5965\u5e0c\u66ff\u5c3c<\/b><\/p>\n

\u5965\u5e0c\u66ff\u5c3c\u662f\u4e00\u79cd\u4e0d\u53ef\u9006\u7684\u7b2c\u4e09\u4ee3\u8868\u76ae\u751f\u957f\u56e0\u5b50\u53d7\u4f53\u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5242\uff08EGFR-TKI\uff09\uff0c\u5728\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u60a3\u8005\uff08\u5305\u62ec\u4f34\u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf\u8f6c\u79fb\uff09\u4e2d\u6709\u786e\u8bc1\u7684\u4e34\u5e8a\u7597\u6548\u3002\u5965\u5e0c\u66ff\u5c3c\uff0840mg \u548c 80mg \u6bcf\u65e5\u4e00\u6b21\u53e3\u670d\u7247\u5242\uff09\u5df2\u5728\u5168\u7403\u7528\u4e8e\u8fd180\u4e07\u540d\u60a3\u8005\u6cbb\u7597\u5404\u79cd\u5df2\u83b7\u6279\u9002\u5e94\u75c7\u3002\u963f\u65af\u5229\u5eb7\u5c06\u7ee7\u7eed\u63a2\u7d22\u5965\u5e0c\u66ff\u5c3c\u7528\u4e8e\u6cbb\u7597\u4e0d\u540c\u75be\u75c5\u5206\u671f\u7684EGFR\u7a81\u53d8\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u60a3\u8005\u3002<\/p>\n

\u5927\u91cf\u8bc1\u636e\u652f\u6301\u5965\u5e0c\u66ff\u5c3c\u5728\u4f34\u6709EGFR\u7a81\u53d8\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u4e2d\u7684\u4f7f\u7528\uff0c\u4e14\u5b83\u662f\u552f\u4e00\u4e00\u4e2a\u53ef\u540c\u65f6\u6539\u5584\u65e9\u671f\uff08ADAURA III\u671f\u4e34\u5e8a\u7814\u7a76\uff09\u548c\u665a\u671f\uff08FLAURA\u548c FLAURA2 III\u671f\u4e34\u5e8a\u7814\u7a76\uff09\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u60a3\u8005\u4e34\u5e8a\u7ed3\u5c40\u7684\u9776\u5411\u7597\u6cd5\u3002<\/p>\n

\u963f\u65af\u5229\u5eb7\u8fd8\u901a\u8fc7SAVANNAH\u548cORCHARD II\u671f\u7814\u7a76\u3001SAFFRON III\u671f\u7814\u7a76\uff0c\u63a2\u7d22\u5965\u5e0c\u66ff\u5c3c\u4e0e\u8d5b\u6c83\u66ff\u5c3c\uff08\u4e00\u79cd\u53e3\u670d\u3001\u5f3a\u6548\u548c\u9ad8\u9009\u62e9\u6027MET-TKI\uff09\u8054\u5408\u7597\u6cd5\uff0c\u4ee5\u53ca\u4e0e\u5176\u4ed6\u6f5c\u5728\u65b0\u836f\u7684\u8054\u5408\u6cbb\u7597\u65b9\u6848\uff0c\u63a2\u7d22\u89e3\u51b3\u80bf\u7624\u8010\u836f\u673a\u5236\u7684\u65b9\u6cd5\u3002<\/p>\n

\u5173\u4e8e\u963f\u65af\u5229\u5eb7\u5728\u80ba\u764c\u9886\u57df\u7684\u7814\u7a76<\/b><\/p>\n

\u963f\u65af\u5229\u5eb7\u6b63\u81f4\u529b\u4e8e\u901a\u8fc7\u65e9\u8bca\u65e9\u6cbb\u63d0\u9ad8\u80ba\u764c\u60a3\u8005\u7684\u6cbb\u6108\u7387\uff0c\u540c\u65f6\u63a8\u52a8\u76f8\u5173\u79d1\u5b66\u4e0d\u65ad\u5411\u524d\u53d1\u5c55\uff0c\u4ee5\u6539\u5584\u8010\u836f\u60a3\u8005\u548c\u665a\u671f\u60a3\u8005\u7684\u6cbb\u7597\u7ed3\u5c40\u3002\u901a\u8fc7\u5b9a\u4e49\u65b0\u7684\u6cbb\u7597\u9776\u70b9\u548c\u8bc4\u4ef7\u521b\u65b0\u7597\u6cd5\uff0c\u963f\u65af\u5229\u5eb7\u81f4\u529b\u4e8e\u5b9e\u73b0\u5c06\u6700\u5408\u9002\u7684\u836f\u7269\u7528\u4e8e\u53ef\u5f97\u5230\u6700\u5927\u5316\u83b7\u76ca\u7684\u60a3\u8005\u3002<\/p>\n

\u516c\u53f8\u4e30\u5bcc\u7684\u4ea7\u54c1\u7ec4\u5408\u5305\u62ec\u9886\u5148\u7684\u80ba\u764c\u836f\u7269\u4ee5\u53ca\u4e0b\u4e00\u9636\u6bb5\u7684\u521b\u65b0\u836f\u7269\uff0c\u5305\u62ec\u5965\u5e0c\u66ff\u5c3c\u548c\u6613\u745e\u6c99\uff08\u5409\u975e\u66ff\u5c3c\uff09\uff1b\u82f1\u98de\u51e1\uff08\u5ea6\u4f10\u5229\u5c24\u5355\u6297\uff09\u548ctremelimumab\uff1b\u4e0e\u7b2c\u4e00\u4e09\u5171\u5408\u4f5c\u5f00\u53d1\u7684\u4f18\u8d6b\u5f97\uff08\u5fb7\u66f2\u59a5\u73e0\u5355\u6297\uff09\u548cdatopotamab deruxtecan\uff1b\u4e0e\u548c\u9ec4\u533b\u836f\u5408\u4f5c\u5f00\u53d1\u7684\u6c83\u745e\u6c99\uff08\u8d5b\u6c83\u66ff\u5c3c\uff09\u4ee5\u53ca\u6a2a\u8de8\u5404\u79cd\u4f5c\u7528\u673a\u5236\u7684\u65b0\u836f\u53ca\u5176\u7ec4\u5408\u7684\u4ea7\u54c1\u7ba1\u7ebf\u3002<\/p>\n

\u963f\u65af\u5229\u5eb7\u662f\u5168\u7403Lung Ambition Alliance\u7684\u521b\u59cb\u6210\u5458\uff0c\u8be5\u5168\u7403\u6027\u8054\u76df\u81f4\u529b\u4e8e\u52a0\u5feb\u521b\u65b0\u6b65\u4f10\uff0c\u5e76\u4e3a\u80ba\u764c\u60a3\u8005\u63d0\u4f9b\u5305\u62ec\u6cbb\u7597\u548c\u6cbb\u7597\u4ee5\u5916\u7684\u5177\u6709\u610f\u4e49\u7684\u6539\u5584\u63aa\u65bd\u3002<\/p>\n

\u5173\u4e8e\u963f\u65af\u5229\u5eb7\u5728\u80bf\u7624\u9886\u57df\u7684\u7814\u7a76<\/b><\/p>\n

\u963f\u65af\u5229\u5eb7\u6b63\u5f15\u9886\u7740\u80bf\u7624\u9886\u57df\u7684\u4e00\u573a\u9769\u547d\uff0c\u81f4\u529b\u63d0\u4f9b\u591a\u5143\u5316\u7684\u80bf\u7624\u6cbb\u7597\u65b9\u6848\uff0c\u4ee5\u79d1\u5b66\u63a2\u7d22\u80bf\u7624\u9886\u57df\u7684\u590d\u6742\u6027\uff0c\u53d1\u73b0\u3001\u7814\u53d1\u5e76\u5411\u60a3\u8005\u63d0\u4f9b\u6539\u53d8\u751f\u547d\u7684\u836f\u7269\u3002<\/p>\n

\u963f\u65af\u5229\u5eb7\u7684\u80bf\u7624\u4e1a\u52a1\u4e13\u6ce8\u4e8e\u6700\u5177\u6311\u6218\u6027\u7684\u80bf\u7624\u75be\u75c5\uff0c\u901a\u8fc7\u6301\u7eed\u4e0d\u65ad\u7684\u521b\u65b0\uff0c\u963f\u65af\u5229\u5eb7\u5df2\u7ecf\u5efa\u7acb\u4e86\u9886\u5148\u5168\u884c\u4e1a\u7684\u591a\u5143\u5316\u4ea7\u54c1\u7ec4\u5408\u548c\u6e20\u9053\uff0c\u6301\u7eed\u63a8\u52a8\u533b\u7597\u5b9e\u8df5\u53d8\u9769\uff0c\u6539\u53d8\u60a3\u8005\u4f53\u9a8c\u3002<\/p>\n

\u963f\u65af\u5229\u5eb7\u7684\u613f\u666f\u65e8\u5728\u91cd\u65b0\u5b9a\u4e49\u764c\u75c7\u6cbb\u7597\uff0c\u4ee5\u671f\u672a\u6765\u7ec8\u7ed3\u764c\u75c7\u8fd9\u4e00\u81f4\u6b7b\u4e4b\u56e0\u3002<\/span><\/p>\n

\u58f0\u660e\uff1a\u672c\u6587\u6d89\u53ca\u672a\u5728\u4e2d\u56fd\u83b7\u6279\u7684\u4ea7\u54c1\u6216\u8005\u9002\u5e94\u75c7\uff0c\u963f\u65af\u5229\u5eb7\u4e0d\u63a8\u8350\u4efb\u4f55\u672a\u88ab\u6279\u836f\u54c1<\/i>\/<\/i>\u9002\u5e94\u75c7\u7684\u4f7f\u7528\u3002<\/i><\/p>\n

\n\n\n\n\n\n\n\n\n\n\n\n
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References <\/b>\u53c2\u8003\u6587\u732e<\/b><\/span><\/p>\n<\/td>\n<\/tr>\n

\n

1. ASCO. Lung Cancer – Non-Small Cell: Introduction. Available at: https:\/\/www.cancer.net\/cancer-types\/lung-cancer-non-small-cell\/types-treatment. Accessed February 2024.<\/span><\/p>\n<\/td>\n<\/tr>\n

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2. LUNGevity Foundation. Types of Lung Cancer. Available at: https:\/\/lungevity.org\/for-patients-caregivers\/lung-cancer-101\/types-of-lung-cancer. Accessed February 2024.    <\/span><\/p>\n<\/td>\n<\/tr>\n

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3. American Cancer Society. What Is Lung Cancer? Available at: https:\/\/www.cancer.org\/cancer\/lung-cancer\/about\/what-is.html#:~:text=About%2080%25%20to%2085%25%20of,(outlook)%20are%20often%20similar. Accessed February 2024.    <\/span><\/p>\n<\/td>\n<\/tr>\n

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4. Cagle PT, et al. Lung Cancer Biomarkers: Present Status and Future Developments. Archives Pathology Lab Med. 2013;137:1191-1198.  <\/span><\/p>\n<\/td>\n<\/tr>\n

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5. Keedy VL, et al. American Society of Clinical Oncology Provisional Clinical Opinion: Epidermal Growth Factor Receptor (EGFR) Mutation Testing for Patients with Advanced Non-Small-Cell Lung Cancer Considering First-Line EGFR Tyrosine Kinase Inhibitor Therapy. J Clin Oncol. 2011:29;2121-27. <\/span><\/p>\n<\/td>\n<\/tr>\n

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6. NCCN, National Comprehensive Cancer Network® (NCCN®). Referenced with permission from the NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) for Non-Small Cell Lung Cancer Version 1.2024.© National Comprehensive Cancer Network, Inc. [2024]. All rights reserved. Accessed [February 14, 2024]. To view the most recent and complete version of the guideline, go online to NCCN.org. NCCN makes no warranties of any kind whatsoever regarding their content, use or application and disclaims any responsibility for their application or use in any way.<\/span><\/p>\n<\/td>\n<\/tr>\n

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7. World Health Organisation. International Agency for Research on Cancer. Lung Fact Sheet. Available at: https:\/\/gco.iarc.fr\/today\/data\/factsheets\/cancers\/15-Lung-fact-sheet.pdf. Accessed February 2024.<\/span><\/p>\n<\/td>\n<\/tr>\n

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8. Cross DA, et al. AZD9291, an Irreversible EGFR TKI, Overcomes T790M-Mediated Resistance to EGFR Inhibitors in Lung Cancer. Cancer Discov. 2014;4(9):1046-1061.<\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table><\/div>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

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