{"id":104962,"date":"2024-01-31T09:56:00","date_gmt":"2024-01-31T02:56:00","guid":{"rendered":"https:\/\/www.xinwengao.com\/cn\/pr\/20240131095600104962"},"modified":"2024-02-01T11:23:29","modified_gmt":"2024-02-01T03:23:29","slug":"%e8%8d%af%e6%98%8e%e5%90%88%e8%81%94%e4%b8%8e%e6%99%ae%e4%bc%97%e5%8f%91%e7%8e%b0%e5%92%8c%e6%b1%87%e8%bf%9e%e8%be%be%e6%88%90%e5%90%88%e4%bd%9c%ef%bc%8c%e6%96%b0%e5%9e%8b%e6%af%92%e7%b4%a0%e8%bf%9e","status":"publish","type":"post","link":"https:\/\/www.xinwengao.com\/cn\/pr\/20240131095600104962","title":{"rendered":"\u836f\u660e\u5408\u8054\u4e0e\u666e\u4f17\u53d1\u73b0\u548c\u6c47\u8fde\u8fbe\u6210\u5408\u4f5c\uff0c\u65b0\u578b\u6bd2\u7d20\u8fde\u63a5\u5b50\u6280\u672f\u8d4b\u80fd\u52a0\u901fADC\u836f\u7269\u53d1\u73b0\u548c\u5f00\u53d1"},"content":{"rendered":"

\u4e0a\u6d77<\/span>2024\u5e741\u670831\u65e5<\/span> \/\u7f8e\u901a\u793e\/ — \u5168\u7403\u9886\u5148\u7684\u4e13\u6ce8\u4e8e\u63d0\u4f9b\u6297\u4f53\u5076\u8054\u836f\u7269\uff08ADC\uff09\u7b49\u751f\u7269\u5076\u8054\u836f\u7269\u7aef\u5230\u7aefCRDMO\u670d\u52a1\u7684\u836f\u660e\u5408\u8054\uff08WuXi XDC, 2268.HK\uff09\uff0c\u4e0e\u4e13\u6ce8\u4e8eADC\u836f\u7269\u5f00\u53d1\u7684\u4e34\u5e8a\u9636\u6bb5\u5e73\u53f0\u516c\u53f8\u666e\u4f17\u53d1\u73b0\uff08Multitude Therapeutics\uff09\u5ba3\u5e03\u8fbe\u6210\u5408\u4f5c\uff0c\u5e76\u548cADC\u836f\u7269\u7814\u7a76\u516c\u53f8\u4e0a\u6d77\u6c47\u8fde\u751f\u7269\u533b\u836f\u6709\u9650\u516c\u53f8\uff08\u4ee5\u4e0b\u7b80\u79f0"\u6c47\u8fde"\uff09\u7b7e\u7f72\u5408\u4f5c\u5907\u5fd8\u5f55\uff08MOU\uff09\uff0c\u5c31\u65b0\u578b\u6bd2\u7d20-\u8fde\u63a5\u5b50\u6280\u672f\u4ee5\u53caADC\u7684\u7814\u7a76\u3001\u5f00\u53d1\u3001\u548c\u751f\u4ea7\uff08CRDMO\uff09\u670d\u52a1\u8fbe\u6210\u5168\u9762\u7684\u5408\u4f5c\u3002<\/p>\n

\n

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<\/span><\/p>\n<\/p><\/div>\n

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\u836f\u660e\u5408\u8054\u9996\u5e2d\u6267\u884c\u5b98\u674e\u9526\u624d\u535a\u58eb<\/b>\u8868\u793a\uff1a"\u666e\u4f17\u53d1\u73b0\u548c\u6c47\u8fde\u5171\u540c\u5f00\u53d1\u7684\u65b0\u578bT-Moiety\u8fde\u63a5\u5b50\u6280\u672f\u4e0e\u6211\u4eec\u5f00\u653e\u5f0f\u7684\u5076\u8054\u6280\u672f\u5e73\u53f0\u76f8\u878d\u5408\uff0c\u5c06\u8d4b\u80fd\u5ba2\u6237\u5b9e\u73b0T moiety – exatecan ADC\u4e34\u5e8a\u524d\u5019\u9009\u836f\u7269\u7684\u5feb\u901f\u4ea4\u4ed8\uff0c\u63d0\u5347\u7814\u53d1\u6548\u7387\u3002\u6211\u4eec\u5f88\u9ad8\u5174\u548c\u884c\u4e1a\u4f19\u4f34\u643a\u624b\uff0c\u4ece\u800c\u6839\u636e\u5ba2\u6237\u7684\u9700\u6c42\u6301\u7eed\u521b\u65b0\u548c\u63d0\u5347\u5e73\u53f0\u6280\u672f\u548c\u80fd\u529b\uff0c\u4ee5\u6211\u4eec\u7684\u4e13\u4e1a\u7ecf\u9a8c\u6253\u9020\u5168\u7403\u9886\u5148\u7684\u5076\u8054\u5de5\u827a\u5e73\u53f0\uff0c\u4ece\u9ad8\u5ea6\u3001\u5e7f\u5ea6\u3001\u548c\u6df1\u5ea6\u5145\u5206\u8d4b\u80fd\u751f\u7269\u5076\u8054\u836f\u884c\u4e1a\u3002"<\/p>\n

\u666e\u4f17\u53d1\u73b0\u548c\u6c47\u8fde<\/b>\u8868\u793a\uff0c<\/span>\u836f\u660e\u5408\u8054\u5728CRDMO\u4e1a\u52a1\u9886\u57df\u5177\u6709\u4e30\u5bcc\u7ecf\u9a8c\u548c\u5353\u8d8a\u80fd\u529b\uff0c\u53cc\u65b9<\/span>\u5f88\u9ad8\u5174\u80fd\u591f\u5728\u6280\u672f\u9886\u57df\u5f3a\u5f3a\u8054\u5408\uff0c\u5176<\/span>\u4e13\u6709\u7684\u65b0\u578bT-Moiety\u8fde\u63a5\u5b50\u80fd\u52a9\u529b\u5927\u5e45\u5ea6\u63d0\u9ad8ADC\u6cbb\u7597\u6548\u679c\uff0c\u66f4\u9ad8\u7684\u8fde\u63a5\u5b50\u7a33\u5b9a\u6027\u4e0e\u4eb2\u6c34\u5c4f\u853d\u6548\u5e94\uff0c\u53ef\u63d0\u9ad8\u6297\u4f53\u5076\u8054\u836f\u7269\u7684\u6574\u4f53\u7a33\u5b9a\u6027\uff0c\u5ef6\u957f\u836f\u7269\u4f5c\u7528\u65f6\u95f4\uff0c\u6709\u6f5c\u529b\u514b\u670d\u591a\u91cd\u80bf\u7624\u8010\u836f\u6027\uff0c\u5728\u6bd2\u526f\u4f5c\u7528\u6ca1\u6709\u589e\u52a0\u7684\u60c5\u51b5\u4e0b\uff0c\u8fdb\u4e00\u6b65\u63d0\u5347\u73b0\u6709ADC\u836f\u7269\u7684\u6cbb\u7597\u7a97\u53e3\uff08\u76f8\u5173\u7814\u7a76\u6210\u679c\u53d1\u8868\u4e8eCancer Discovery 2023;13(4):950-73\uff09\u3002\u6b64\u6b21<\/span>\u5408\u4f5c\u5c06\u52a9\u529b\u66f4\u591aADC\u5f00\u53d1\u516c\u53f8\u7a33\u5b9a\u5feb\u901f\u5730\u83b7\u5f97\u8fd9\u7c7b\u6709\u6548\u8f7d\u8377-\u8fde\u63a5\u5b50\uff0c\u9020\u798f\u66f4\u591a\u60a3\u8005\u3002<\/p>\n

\u5173\u4e8e\u836f\u660e\u5408\u8054\uff08<\/b>WuXi XDC<\/b>\uff09<\/b><\/p>\n

\u836f\u660e\u5408\u8054\u751f\u7269\u6280\u672f\u6709\u9650\u516c\u53f8\uff08\u80a1\u7968\u4ee3\u7801\uff1a2268.HK\uff0c\u4ee5\u4e0b\u7b80\u79f0"\u836f\u660e\u5408\u8054"\uff09\u662f\u5168\u7403\u9886\u5148\u7684\u751f\u7269\u5076\u8054\u836f\u5408\u540c\u7814\u7a76\u3001\u5f00\u53d1\u548c\u751f\u4ea7\uff08CRDMO\uff09\u4f01\u4e1a\uff0c\u4e13\u6ce8\u4e8e\u63d0\u4f9b\u6297\u4f53\u5076\u8054\u836f\u7269\uff08ADC\uff09\u7b49\u751f\u7269\u5076\u8054\u836f\u7aef\u5230\u7aef\u670d\u52a1\uff0c\u6db5\u76d6\u6297\u4f53\u4e2d\u95f4\u4f53\u548c\u5176\u4ed6\u5076\u8054\u751f\u7269\u836f\u3001\u8fde\u63a5\u5b50\/\u5316\u5b66\u6709\u6548\u8f7d\u8377\u3001\u5076\u8054\u539f\u6db2\u53ca\u5236\u5242\u7b49\u7814\u53d1\u548cGMP\u751f\u4ea7\u9886\u57df\u3002\u66f4\u591a\u4fe1\u606f\uff0c\u8bf7\u67e5\u8be2: wuxixdc.com<\/a>\u3002<\/p>\n

\u8054\u7cfb\u65b9\u5f0f<\/b><\/p>\n

\u6295\u8d44\u8005\u5173\u7cfb\uff1awuxixdc.ir@wuxibiologics.com<\/a>
\u5a92\u4f53\u95ee\u8be2\uff1awuxixdc_pr@wuxibiologics.com<\/a>
\u4e1a\u52a1\u53d1\u5c55\uff1awuxixdc_info@wuxibiologics.com<\/a><\/p>\n

\u5173\u4e8e\u666e\u4f17\u53d1\u73b0<\/b><\/p>\n

\u666e\u4f17\u53d1\u73b0\u662f\u4e00\u5bb6\u4e13\u6ce8\u4e8eADC\u836f\u7269\u5f00\u53d1\u7684\u4e34\u5e8a\u9636\u6bb5\u516c\u53f8\uff0c\u516c\u53f8\u521b\u59cb\u4eba\u5177\u6709\u8fde\u7eed\u6210\u529f\u7684\u521b\u4e1a\u7ecf\u9a8c\u3002\u666e\u4f17\u53d1\u73b0\u80fd\u591f\u5f00\u53d1\u51fa\u884c\u4e1a\u9886\u5148\u7684ADC\u4ea7\u54c1\uff0c\u5176\u7ade\u4e89\u4f18\u52bf\u5728\u4e8e\u5177\u6709\u4e24\u4e2a\u6280\u672f\u5e73\u53f0\uff1aMabArray™\uff08Sci Adv. 2020 6(11): EAAX2271\uff09\u2014\u2014 \u4e00\u79cd\u7528\u4e8e\u53d1\u73b0\u65b0\u9896\u7684\u7ec6\u80de\u8868\u9762\u6297\u80bf\u7624\u9776\u70b9\u4ee5\u6784\u5efaFirst-in-Class \u9776\u6807\u7684\u6297\u4f53\u5e73\u53f0\uff0c\u4ee5\u53caT1000 \u2014\u2014 \u4e00\u79cd\u7528\u4e8e\u5f00\u53d1ADC\u7684\u65b0\u578b\u8fde\u63a5\u5b50\/\u6709\u6548\u8f7d\u8377\u6280\u672f\uff0c\u5229\u7528\u8be5\u5e73\u53f0\u5236\u5907\u7684ADC\u5728\u65c1\u89c2\u8005\u6548\u5e94\u3001\u7597\u6548\u548c\u5b89\u5168\u6027\u65b9\u9762\u80fd\u591f\u83b7\u5f97\u66f4\u4f18\u5316\u7684\u5e73\u8861\u3002MabArray™\u4e0eT1000\u7684\u7ed3\u5408\u4ea7\u751f\u4e86\u663e\u8457\u7684\u534f\u540c\u6548\u5e94\uff0c\u4f7f\u666e\u4f17\u53d1\u73b0\u80fd\u591f\u6784\u5efa\u4e00\u5957ADC"\u56fe\u518c"\uff0c\u8be5"\u56fe\u518c"\u6709\u671b\u7528\u4e8e\u6cbb\u7597\u5177\u6709\u9ad8\u5ea6\u672a\u6ee1\u8db3\u6cbb\u7597\u9700\u6c42\u7684\u6076\u6027\u80bf\u7624\uff0c\u5e76\u5b9e\u73b0\u66f4\u9ad8\u548c\u66f4\u6301\u4e45\u7684\u54cd\u5e94\u3002<\/p>\n

\u666e\u4f17\u53d1\u73b0\u66fe\u83b7\u5f97\u4e2d\u56fd\u521b\u65b0\u521b\u4e1a\u5927\u8d5b2023\u5e74\u603b\u51b3\u8d5b"\u521b\u65b0\u521b\u4e1a50\u5f3a"\uff0c\u62e5\u6709\u9ad8\u65b0\u6280\u672f\u4f01\u4e1a\u3001\u4e0a\u6d77\u5e02"\u79d1\u6280\u5c0f\u5de8\u4eba"\u57f9\u80b2\u4f01\u4e1a\u3001\u5f90\u6c47\u533a\u4f01\u4e1a\u6280\u672f\u4e2d\u5fc3\u3001"\u521b\u5ba2\u4e2d\u56fd"2020\u4e0a\u6d77\u6700\u5177\u6295\u8d44\u6f5c\u529b50\u4f73\u521b\u4e1a\u4f01\u4e1a\u3001\u4e2d\u56fd\u751f\u7269\u533b\u836f\u4f01\u4e1a\u6700\u5177\u521b\u65b0\u529b\u4f01\u4e1a50\u5f3a\u7b49\u8363\u8a89\uff0c\u6295\u8d44\u65b9\u5305\u62ec\u5143\u751f\u8d44\u672c\u3001\u5317\u6781\u5149\u521b\u6295\u3001\u51ef\u98ce\u521b\u6295\u3001\u6b63\u5fc3\u8c37\u8d44\u672c\u548cM Ventures\uff08\u9ed8\u514b\u4f01\u4e1a\u6218\u7565\u6295\u8d44\u57fa\u91d1\uff09\u7b49\u77e5\u540d\u6295\u8d44\u673a\u6784\u3002<\/p>\n

\u8054\u7cfb\u65b9\u5f0f
\u4e1a\u52a1\u53d1\u5c55\uff1ainfo@multitudetherapeutics.com<\/a> <\/p>\n

\u5173\u4e8e\u6c47\u8fde<\/b>\uff08<\/b>Hyslink<\/b>\uff09<\/b><\/p>\n

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\u8054\u7cfb\u65b9\u5f0f
\u4e1a\u52a1\u53d1\u5c55\uff1abd@hyslink.com<\/a><\/p>\n

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