{"id":104156,"date":"2024-01-23T11:12:00","date_gmt":"2024-01-23T04:12:00","guid":{"rendered":"https:\/\/www.xinwengao.com\/cn\/pr\/20240123111200104156"},"modified":"2024-01-24T01:25:39","modified_gmt":"2024-01-23T17:25:39","slug":"%e7%94%98%e8%8e%b1%e6%88%98%e7%95%a5%e5%90%88%e4%bd%9c%e4%bc%99%e4%bc%b4sagimet-biosciences%e5%ae%a3%e5%b8%83asc40%ef%bc%88%e5%9c%b0%e5%b0%bc%e6%b3%95%e5%8f%b8%e4%bb%96%ef%bc%89%e6%b2%bb%e7%96%97","status":"publish","type":"post","link":"https:\/\/www.xinwengao.com\/cn\/pr\/20240123111200104156","title":{"rendered":"\u7518\u83b1\u6218\u7565\u5408\u4f5c\u4f19\u4f34Sagimet Biosciences\u5ba3\u5e03ASC40\uff08\u5730\u5c3c\u6cd5\u53f8\u4ed6\uff09\u6cbb\u7597\u7ecf\u809d\u7a7f\u6d3b\u68c0\u8bc1\u5b9e\u7ea4\u7ef4\u53162\/3\u671fNASH\u60a3\u8005\u7684IIb\u671fFASCINATE-2\u4e34\u5e8a\u8bd5\u9a8c\u53d6\u5f97\u79ef\u6781\u9876\u7ebf\u7ed3\u679c"},"content":{"rendered":"<p><p><i>\u5728\u4e00\u9879\u9488\u5bf9<\/i><i>168<\/i><i>\u4f8b\u7ea4\u7ef4\u5316<\/i><i>2<\/i><i>\u671f\u6216<\/i><i>3<\/i><i>\u671f<\/i><i>NASH<\/i><i>\u60a3\u8005\u8fdb\u884c\u7684<\/i><i>52<\/i><i>\u5468\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\uff0c\u5730\u5c3c\u6cd5\u53f8\u4ed6\u5728\u4e3b\u8981\u7ec8\u70b9\u548c\u591a\u4e2a\u6b21\u8981\u7ec8\u70b9\u5747\u53d6\u5f97\u4e86\u7edf\u8ba1\u5b66\u663e\u8457\u6027\u5dee\u5f02\u7684\u7ed3\u679c<\/i><\/p>\n<p class=\"prnml40\"><span id=\"spanHghltad6b\"><i>&#8211;&nbsp; &nbsp; &nbsp; \u4e3b\u8981\u7597\u6548\u7ec8\u70b9\uff1a<\/i><\/span><\/p>\n<ul type=\"disc\">\n<li style=\"list-style-type: none\">\n<ul type=\"disc\">\n<li><i>\u5730\u5c3c\u6cd5\u53f8\u4ed6\u6cbb\u7597\u7ec4<\/i><i>36%<\/i><i>\u7684\u60a3\u8005\u8fbe\u5230<\/i><i>NASH<\/i><i>\u6539\u5584\u4e14\u7ea4\u7ef4\u5316\u65e0\u6076\u5316\u4e14<\/i><i>NAS<\/i><i>\uff08<\/i><i>NAFLD<\/i><i>\u6d3b\u52a8\u5ea6\u8bc4\u5206\uff09\u964d\u4f4e\u2265<\/i><i>2<\/i><i>\u5206\uff0c\u800c\u5b89\u6170\u5242\u7ec4\u4e3a<\/i><i>13%<\/i><i>\uff08<\/i><i>p=0.002<\/i><i>\uff09<\/i><\/li>\n<li><i>\u5730\u5c3c\u6cd5\u53f8\u4ed6\u6cbb\u7597\u7ec4<\/i><i>52%<\/i><i>\u7684\u60a3\u8005\u8fbe\u5230<\/i><i>NAS<\/i><i>\u964d\u4f4e\u2265<\/i><i>2<\/i><i>\u5206\u4e14\u7ea4\u7ef4\u5316\u65e0\u6076\u5316\uff0c\u800c\u5b89\u6170\u5242\u7ec4\u4e3a<\/i><i>20%<\/i><i>\uff08<\/i><i>p=0.0001<\/i><i>\uff09<\/i><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p><i>\u5730\u5c3c\u6cd5\u53f8\u4ed6\u603b\u4f53\u8010\u53d7\u6027\u826f\u597d<\/i><\/p>\n<p><i>\u57fa\u4e8e\u548c<\/i><i>Sagimet Biosciences Inc.<\/i><i>\u7684\u72ec\u5bb6\u8bb8\u53ef\u534f\u8bae\uff0c\u6b4c\u793c\u7684\u5168\u8d44\u5b50\u516c\u53f8\u7518\u83b1\u5236\u836f\u6709\u9650\u516c\u53f8\uff08&quot;\u7518\u83b1&quot;\uff09\u62e5\u6709<\/i><i>ASC40<\/i><i>\uff08\u5730\u5c3c\u6cd5\u53f8\u4ed6\uff09\u5728\u5927\u4e2d\u534e\u533a\u7684\u5f00\u53d1\u3001\u751f\u4ea7\u548c\u5546\u4e1a\u5316\u6743\u76ca<\/i><\/p>\n<p><span class=\"legendSpanClass\">\u4e0a\u6d77<\/span><span class=\"legendSpanClass\">2024\u5e741\u670823\u65e5<\/span> \/\u7f8e\u901a\u793e\/ &#8212; \u6b4c\u793c\u5236\u836f\u6709\u9650\u516c\u53f8\uff08\u6b4c\u793c\uff0c\u9999\u6e2f\u8054\u4ea4\u6240\u4ee3\u7801\uff1a1672\uff09\u65d7\u4e0b\u5168\u8d44\u5b50\u516c\u53f8\u7518\u83b1\u5236\u836f\u6709\u9650\u516c\u53f8\uff08&quot;\u7518\u83b1&quot;\uff09\u5ba3\u5e03\u5176\u6218\u7565\u5408\u4f5c\u4f19\u4f34Sagimet Biosciences Inc.\uff08Sagimet\uff0c\u7eb3\u65af\u8fbe\u514b\uff1aSGMT\uff09<span id=\"spanHghlta495\">\u4eca<\/span>\u65e5\u53d1\u5e03\u4e86ASC40\uff08\u5730\u5c3c\u6cd5\u53f8\u4ed6\uff09\u5bf9\u7167\u5b89\u6170\u5242\u6cbb\u7597\u7ecf\u809d\u7a7f\u6d3b\u68c0\u8bc1\u5b9e\u7684\u7ea4\u7ef4\u53162\u671f\u62163\u671f\uff08F2\/F3\uff09\u975e\u9152\u7cbe\u6027\u8102\u80aa\u6027\u809d\u708e\uff08NASH\uff09\u60a3\u8005\u7684FASCINATE-2 IIb\u671f\u4e34\u5e8a\u8bd5\u9a8c\u5728\u7b2c52\u5468\u53d6\u5f97\u7684\u79ef\u6781\u9876\u7ebf\u7ed3\u679c\u3002\u5728\u6b64\u9879\u8bd5\u9a8c\u4e2d\uff0c\u4e0e\u5b89\u6170\u5242\u76f8\u6bd4\uff0c\u53e3\u670d\u9009\u62e9\u6027FASN\u6291\u5236\u5242\u5730\u5c3c\u6cd5\u53f8\u4ed6\u5728\u4e24\u4e2a\u4e3b\u8981\u7ec8\u70b9\uff08NASH\u6539\u5584\u4e14\u7ea4\u7ef4\u5316\u65e0\u6076\u5316\u4e14NAS\u964d\u4f4e\u22652\u5206\uff0c\u4ee5\u53caNAS\u964d\u4f4e\u22652\u5206\u4e14\u7ea4\u7ef4\u5316\u65e0\u6076\u5316\uff09\u8fbe\u5230\u4e86\u7edf\u8ba1\u5b66\u663e\u8457\u6027\u5dee\u5f02\u7684\u6539\u5584\u3002\u4e0e\u5b89\u6170\u5242\u7ec4\u76f8\u6bd4\uff0c\u5730\u5c3c\u6cd5\u53f8\u4ed6\u7ec4\u60a3\u8005\u7684\u7ea4\u7ef4\u5316\u6539\u5584\u22651\u671f\u4e14NASH\u65e0\u6076\u5316\u8fbe\u5230\u4e86\u7edf\u8ba1\u5b66\u663e\u8457\u6027\u5dee\u5f02\uff0c\u78c1\u5171\u632f\u8d28\u5b50\u5bc6\u5ea6\u8102\u80aa\u5206\u6570\uff08MRI-PDFF\uff09\u4e0b\u964d\u226530%\u7684\u5e94\u7b54\u8005\u6bd4\u4f8b\u66f4\u9ad8\u3002<\/p>\n<p>\u57fa\u4e8e\u548c<span id=\"spanHghlt0848\">Sagimet\u7684<\/span>\u72ec\u5bb6\u8bb8\u53ef\u534f\u8bae\uff0c\u7518\u83b1\u62e5\u6709ASC40\u5728\u5927\u4e2d\u534e\u533a\u7684\u5f00\u53d1\u3001\u751f\u4ea7\u548c\u5546\u4e1a\u5316\u6743\u76ca\u3002\u6709\u5173\u5ba3\u5e03FASCINATE-2\u7684IIb\u671f\u4e34\u5e8a\u7814\u7a76\u9876\u7ebf\u7ed3\u679c\u65b0\u95fb\u53ef\u89c1<b><a href=\"https:\/\/ir.sagimet.com\/news-releases\/news-release-details\/sagimet-biosciences-announces-positive-topline-results-phase-2b\" target=\"_blank\" rel=\"nofollow noopener\">\u6b64\u5904<\/a><\/b>\u3002&nbsp;<\/p>\n<p>IIb\u671fFASCINATE-2\u9876\u7ebf\u7ed3\u679c<br \/><b>\u5730\u5c3c\u6cd5\u53f8\u4ed6\u6cbb\u7597\u7b2c<\/b><b>52<\/b><b>\u5468\u65f6\uff0c\u4e3b\u8981\u7ec8\u70b9\u548c\u5176\u4ed6\u7ec8\u70b9\u7684\u6539\u5584\u8fbe\u5230\u7edf\u8ba1\u5b66\u663e\u8457\u6027\u5dee\u5f02<\/b><\/p>\n<div>\n<table border=\"0\" cellspacing=\"0\" cellpadding=\"1\" class=\"prnbcc\">\n<tbody>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\"><\/td>\n<td class=\"prnpr2 prnpl2 prnvab prntac prncbts prnbrbrs prnbbbs prnsblb1\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\"><b>\u5730\u5c3c\u6cd5\u53f8\u4ed6<\/b><br \/><b>50\u6beb\u514b(n=81)<\/b><\/span><\/p>\n<\/td>\n<td class=\"prngen4\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\"><b>\u5b89\u6170\u5242<\/b><br \/><b>(n=45)<\/b><\/span><\/p>\n<\/td>\n<td class=\"prngen4\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\"><b>P\u503c<\/b><br \/><b>\u5bf9\u6bd4\u5b89\u6170\u5242<\/b><\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen5\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\"><b>\u4e3b\u8981\u7ec8\u70b9<\/b><\/span><\/p>\n<\/td>\n<td class=\"prnpr10 prnpl2 prnvab prncbts prnbrbrs prnbbbs prnsblb1\" colspan=\"1\" rowspan=\"1\"><\/td>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\"><\/td>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\"><\/td>\n<\/tr>\n<tr>\n<td class=\"prngen5\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml40\"><span class=\"prnews_span\">NASH\u6539\u5584\u4e14\u7ea4\u7ef4\u5316\u65e0\u6076\u5316\u4e14NAS\u964d\u4f4e\u22652\u5206<\/span><\/p>\n<\/td>\n<td class=\"prngen4\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">36&nbsp;%<\/span><\/p>\n<\/td>\n<td class=\"prngen7\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">13&nbsp;%<\/span><\/p>\n<\/td>\n<td class=\"prngen8\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">0.002<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen5\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml40\"><span class=\"prnews_span\">NAS\u964d\u4f4e\u22652\u5206\u4e14\u7ea4\u7ef4\u5316\u65e0\u6076\u5316<\/span><\/p>\n<\/td>\n<td class=\"prngen4\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">52&nbsp;%<\/span><\/p>\n<\/td>\n<td class=\"prngen7\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">20&nbsp;%<\/span><\/p>\n<\/td>\n<td class=\"prngen8\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">0.0001<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen9\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\"><b>\u5176\u4ed6\u7ec8\u70b9<\/b><\/span><\/p>\n<\/td>\n<td class=\"prngen10\" colspan=\"1\" rowspan=\"1\"><\/td>\n<td class=\"prngen10\" colspan=\"1\" rowspan=\"1\"><\/td>\n<td class=\"prngen10\" colspan=\"1\" rowspan=\"1\"><\/td>\n<\/tr>\n<tr>\n<td class=\"prngen9\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml40\"><span class=\"prnews_span\">\u7ea4\u7ef4\u5316\u6539\u5584\u22651\u5206\u4e14NASH\u65e0\u6076\u5316<\/span><\/p>\n<\/td>\n<td class=\"prngen7\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">41&nbsp;%<\/span><\/p>\n<\/td>\n<td class=\"prngen7\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">18&nbsp;%<\/span><\/p>\n<\/td>\n<td class=\"prngen8\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">0.005<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen9\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml40\"><span class=\"prnews_span\">NASH\u6539\u5584\u4e14\u7ea4\u7ef4\u5316\u65e0\u6076\u5316<\/span><\/p>\n<\/td>\n<td class=\"prngen7\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">38&nbsp;%<\/span><\/p>\n<\/td>\n<td class=\"prngen7\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">16&nbsp;%<\/span><\/p>\n<\/td>\n<td class=\"prngen8\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">0.002<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen9\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml40\"><span class=\"prnews_span\">\u4eba\u5de5\u667a\u80fd\u75c5\u7406\u7ea4\u7ef4\u5316\u8bc4\u4f30(qFibrosis)*<\/span><\/p>\n<\/td>\n<td class=\"prngen8\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">-0.3<\/span><\/p>\n<\/td>\n<td class=\"prngen8\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">0.1<\/span><\/p>\n<\/td>\n<td class=\"prngen8\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">0.002<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen9\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml40\"><span class=\"prnews_span\">ALT\u8f83\u57fa\u7ebf\u53d8\u5316\u7684\u767e\u5206\u6bd4<\/span><\/p>\n<\/td>\n<td class=\"prngen7\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">-30.5&nbsp;%<\/span><\/p>\n<\/td>\n<td class=\"prngen7\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">-17.2&nbsp;%<\/span><\/p>\n<\/td>\n<td class=\"prngen8\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">0.03<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen9\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml40\"><span class=\"prnews_span\">MRI-PDFF\u5e94\u7b54\u7387**<\/span><\/p>\n<\/td>\n<td class=\"prngen7\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">65&nbsp;%<\/span><\/p>\n<\/td>\n<td class=\"prngen7\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">21&nbsp;%<\/span><\/p>\n<\/td>\n<td class=\"prngen7\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">&lt;0.0001<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen9\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml40\"><span class=\"prnews_span\">FibroScan AST (FAST)\u8bc4\u5206<\/span><\/p>\n<\/td>\n<td class=\"prngen8\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">-0.3<\/span><\/p>\n<\/td>\n<td class=\"prngen8\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">-0.1<\/span><\/p>\n<\/td>\n<td class=\"prngen7\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">&lt;0.0001<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen9\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml40\"><span class=\"prnews_span\">\u4f4e\u5bc6\u5ea6\u8102\u86cb\u767d(mg\/dL)***<\/span><\/p>\n<\/td>\n<td class=\"prngen8\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">-19.1<\/span><\/p>\n<\/td>\n<td class=\"prngen8\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">-9.1<\/span><\/p>\n<\/td>\n<td class=\"prngen8\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">&#8212;<\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table><\/div>\n<div>\n<table border=\"0\" cellspacing=\"0\" cellpadding=\"1\" class=\"prnbcc\">\n<tbody>\n<tr>\n<td class=\"prngen11\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\"><i>\u6539\u826f\u610f\u5411\u6cbb\u7597\u4eba\u7fa4\uff08mITT\uff09\u5305\u62ec\u8fdb\u884c\u4e86\u4e24\u6b21\u6d3b\u68c0\u7684\u6240\u6709\u60a3\u8005\uff1b\u5305\u62ec\u622a\u81f3\u672c\u65b0\u95fb\u7a3f\u53d1\u5e03\u4e4b\u65e5\u5df2\u5b8c\u6210\u5206\u6790\u7684\u6b21\u8981\u7ec8\u70b9<\/i><\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen11\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\"><i>*\u4eba\u5de5\u667a\u80fd\uff08AI\uff09\u6570\u5b57\u75c5\u7406\u8bc4\u4f30\u57fa\u4e8e\u4e8c\u6b21\u8c10\u6ce2\u751f\u6210\uff08SHG\uff0cHistoIndex\uff09<\/i><\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen11\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\"><i>** MRI-PDFF\u54cd\u5e94\u662f\u6307\u6cbb\u7597\u7ed3\u675f\u65f6\u809d\u810f\u8102\u80aa\u76f8\u5bf9\u51cf\u5c11\u226530%\u7684\u60a3\u8005<\/i><\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen11\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\"><i>***\u57fa\u7ebfLDL-C &gt; 100 mg\/dL; \u5206\u522b\u5bf9n=32\u548cn=27\u7684\u5730\u5c3c\u6cd5\u53f8\u4ed6\u7ec4\u548c\u5b89\u6170\u5242\u7ec4\u60a3\u8005\u8fdb\u884c\u63a2\u7d22\u6027\u5206\u6790<\/i><\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table><\/div>\n<p>&nbsp;<\/p>\n<p><b>\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027<\/b><\/p>\n<p>\u4e0e\u4e4b\u524d\u7684\u7814\u7a76\u4e00\u6837\uff0c\u672a\u89c2\u5bdf\u5230\u4e0e\u6cbb\u7597\u76f8\u5173\u7684\u4e25\u91cd\u4e0d\u826f\u4e8b\u4ef6\uff08SAE\uff09\uff0c\u5927\u591a\u6570\u4e0d\u826f\u4e8b\u4ef6\uff08AE\uff09\u6027\u8d28\u4e3a\u8f7b\u81f3\u4e2d\u5ea6\uff081\u7ea7\u548c2\u7ea7\uff09\u3002\u65e0\u22653\u7ea7\u4e0e\u6cbb\u7597\u76f8\u5173\u7684AE\u3002\u6309\u7cfb\u7edf\u5668\u5b98\u5206\u7c7b\uff08\u5728\u672c\u7814\u7a76\u4e2d\u22655%\u7684\u60a3\u8005\u4e2d\u89c2\u5bdf\u5230\uff09\u6700\u5e38\u89c1\u7684\u6cbb\u7597\u76f8\u5173\u4e0d\u826f\u4e8b\u4ef6\u5305\u62ec\u773c\u90e8\uff08\u5730\u5c3c\u6cd5\u53f8\u4ed6\u7ec415.2%\uff0c\u5b89\u6170\u5242\u7ec416.1%\uff09\u3001\u80c3\u80a0\u9053\uff08\u5730\u5c3c\u6cd5\u53f8\u4ed6\u7ec411.6%\uff0c\u5b89\u6170\u5242\u7ec48.9%\uff09\u4ee5\u53ca\u76ae\u80a4\u548c\u76ae\u4e0b\u7ec4\u7ec7\uff08\u5730\u5c3c\u6cd5\u53f8\u4ed6\u7ec422.3%\uff0c\u5b89\u6170\u5242\u7ec47.1%\uff09\u3002\u5bfc\u81f4\u6cbb\u7597\u505c\u6b62\u7684\u6cbb\u7597\u671f\u95f4\u51fa\u73b0\u7684\u4e0d\u826f\u4e8b\u4ef6\uff08TEAE\uff09\u53d1\u751f\u7387\uff1a\u5730\u5c3c\u6cd5\u53f8\u4ed6\u7ec4\u4e3a19.6%\uff0c\u5b89\u6170\u5242\u7ec4\u4e3a5.4%\u3002<\/p>\n<p><b>\u5173\u4e8e<\/b><b>IIb<\/b><b>\u671f<\/b><b>FASCINATE-2<\/b><b>\u4e34\u5e8a\u8bd5\u9a8c<\/b><\/p>\n<p>IIb\u671fFASCINATE-2\u4e34\u5e8a\u8bd5\u9a8c\u662f\u4e00\u9879\u4e3a\u671f52\u5468\u7684\u968f\u673a\u3001\u53cc\u76f2\u3001\u5b89\u6170\u5242\u5bf9\u7167\u8bd5\u9a8c\uff0c\u5728168\u4f8b\u7ecf\u809d\u7a7f\u6d3b\u68c0\u8bc1\u5b9e\u7684NAS\u22654\u3001\u6709\u4e2d\u81f3\u91cd\u5ea6\u7ea4\u7ef4\u5316\uff08F2\u671f\u6216F3\u671f\uff09\u7684NASH\u60a3\u8005\u4e2d\u8bc4\u4f30\u4e86\u5730\u5c3c\u6cd5\u53f8\u4ed6\u76f8\u8f83\u4e8e\u5b89\u6170\u5242\u7684\u5b89\u5168\u6027\u548c\u7ec4\u7ec7\u5b66\u5f71\u54cd\u3002<\/p>\n<p><b>\u5173\u4e8e\u7518\u83b1<\/b><\/p>\n<p>\u7518\u83b1\u6210\u7acb\u4e8e2019\u5e74\uff0c\u662f\u6b4c\u793c\u5236\u836f\u6709\u9650\u516c\u53f8\u7684\u5168\u8d44\u5b50\u516c\u53f8\uff0c\u81f4\u529b\u4e8eNASH\u9886\u57df\u65b0\u836f\u7684\u7814\u53d1\u548c\u5546\u4e1a\u5316\u3002\u7518\u83b1\u6709\u4e09\u79cd\u9488\u5bf9\u4e09\u79cd\u4e0d\u540c\u9776\u70b9\uff08FASN\u3001THR\u03b2\u548cFXR\uff09\u7684\u4e34\u5e8a\u9636\u6bb5\u5019\u9009\u836f\u7269\uff0c\u4ee5\u53ca\u4e09\u79cd\u8054\u5408\u7597\u6cd5\u3002<\/p>\n<p>\u6b32\u4e86\u89e3\u66f4\u591a\u4fe1\u606f\uff0c\u8bf7\u8bbf\u95ee<a href=\"http:\/\/www.gannexpharma.com\/\" target=\"_blank\" rel=\"nofollow noopener\">www.gannexpharma.com<\/a>\u3002<\/p>\n<p><b>\u5173\u4e8e\u6b4c\u793c<\/b><\/p>\n<p>\u6b4c\u793c\u662f\u4e00\u5bb6\u5728\u9999\u6e2f\u8bc1\u5238\u4ea4\u6613\u6240\u4e0a\u5e02\uff081672.HK\uff09\u7684\u521b\u65b0\u7814\u53d1\u9a71\u52a8\u578b\u751f\u7269\u79d1\u6280\u516c\u53f8\uff0c\u6db5\u76d6\u4e86\u4ece\u65b0\u836f\u7814\u53d1\u81f3\u751f\u4ea7\u548c\u5546\u4e1a\u5316\u7684\u5b8c\u6574\u4ef7\u503c\u94fe\u3002\u6b4c\u793c\u7684\u7ba1\u7406\u56e2\u961f\u5177\u5907\u6df1\u539a\u7684\u4e13\u4e1a\u77e5\u8bc6\u53ca\u4f18\u79c0\u7684\u8fc7\u5f80\u6210\u5c31\uff0c\u5728\u56e2\u961f\u7684\u5e26\u9886\u4e0b\uff0c\u6b4c\u793c\u805a\u7126\u4e09\u5927\u4e34\u5e8a\u9700\u6c42\u5c1a\u672a\u6ee1\u8db3\u7684\u533b\u7597\u9886\u57df\uff1a\u75c5\u6bd2\u6027\u75be\u75c5\u3001\u975e\u9152\u7cbe\u6027\u8102\u80aa\u6027\u809d\u708e\u548c\u80bf\u7624\uff0c\u5e76\u4ee5\u5168\u7403\u5316\u7684\u89c6\u91ce\u8fdb\u884c\u5e03\u5c40\u3002\u51ed\u501f\u5353\u8d8a\u7684\u6267\u884c\u529b\uff0c\u6b4c\u793c\u5feb\u901f\u63a8\u8fdb\u836f\u7269\u7ba1\u7ebf\u5f00\u53d1\uff0c\u4e89\u53d6\u5728\u56fd\u9645\u7ade\u4e89\u4e2d\u5360\u636e\u9886\u5148\u5730\u4f4d\u3002\u6b4c\u793c\u76ee\u524d\u62e5\u6709\u591a\u6b3e\u5728\u7814\u836f\u7269, \u6700\u524d\u6cbf\u7684\u5019\u9009\u836f\u7269\u5305\u62ecASC22\uff08\u4e59\u809d\u529f\u80fd\u6027\u6cbb\u6108\uff09\u3001ASC40\uff08\u75e4\u75ae\uff09\u3001ASC40\uff08\u590d\u53d1\u6027\u80f6\u8d28\u6bcd\u7ec6\u80de\u7624\uff09\u3001ASC40(\u975e\u9152\u7cbe\u6027\u8102\u80aa\u6027\u809d\u708e)\u3001ASC41(\u975e\u9152\u7cbe\u6027\u8102\u80aa\u6027\u809d\u708e)\u53caASC61\uff08\u665a\u671f\u5b9e\u4f53\u7624\uff09\u3002<\/p>\n<p>\u6b32\u4e86\u89e3\u66f4\u591a\u4fe1\u606f\uff0c\u656c\u8bf7\u767b\u5f55\u7f51\u7ad9\uff1a<a href=\"\/\/10.86.178.52\/C$\/ConvertWordToHTML\/PrimaryContentDownloadPath\/www.ascletis.com\" target=\"_blank\" rel=\"nofollow noopener\">www.ascletis.com<\/a>\u3002<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u5728\u4e00\u9879\u9488\u5bf9168\u4f8b\u7ea4\u7ef4\u53162\u671f\u62163\u671fNASH\u60a3\u8005\u8fdb\u884c\u768452\u5468\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\uff0c\u5730\u5c3c\u6cd5\u53f8\u4ed6\u5728\u4e3b\u8981\u7ec8\u70b9\u548c\u591a\u4e2a\u6b21\u8981\u7ec8\u70b9\u5747\u53d6\u5f97\u4e86\u7edf\u8ba1\u5b66\u663e\u8457\u6027\u5dee\u5f02\u7684\u7ed3\u679c &#8211;&nbsp; &nbsp; &nbsp; \u4e3b\u8981\u7597\u6548\u7ec8\u70b9\uff1a \u5730\u5c3c\u6cd5\u53f8\u4ed6\u6cbb\u7597\u7ec436%\u7684\u60a3\u8005\u8fbe\u5230NASH\u6539\u5584\u4e14\u7ea4\u7ef4\u5316\u65e0\u6076\u5316\u4e14NAS\uff08NAFLD\u6d3b\u52a8\u5ea6\u8bc4\u5206\uff09\u964d\u4f4e\u22652\u5206\uff0c\u800c\u5b89\u6170\u5242\u7ec4\u4e3a13%\uff08p=0.002\uff09 \u5730\u5c3c\u6cd5\u53f8\u4ed6\u6cbb\u7597\u7ec452%\u7684\u60a3\u8005\u8fbe\u5230NAS\u964d\u4f4e\u22652\u5206\u4e14\u7ea4\u7ef4\u5316\u65e0\u6076\u5316\uff0c\u800c\u5b89\u6170\u5242\u7ec4\u4e3a20%\uff08p=0.0001\uff09 \u5730\u5c3c\u6cd5\u53f8\u4ed6\u603b\u4f53\u8010\u53d7\u6027\u826f\u597d \u57fa\u4e8e\u548cSagimet Biosciences Inc.\u7684\u72ec\u5bb6\u8bb8\u53ef\u534f\u8bae\uff0c\u6b4c\u793c\u7684\u5168\u8d44\u5b50\u516c\u53f8\u7518\u83b1\u5236\u836f\u6709\u9650\u516c\u53f8\uff08&quot;\u7518\u83b1&quot;\uff09\u62e5\u6709ASC40\uff08\u5730\u5c3c\u6cd5\u53f8\u4ed6\uff09\u5728\u5927\u4e2d\u534e\u533a\u7684\u5f00\u53d1\u3001\u751f\u4ea7\u548c\u5546\u4e1a\u5316\u6743\u76ca \u4e0a\u6d772024\u5e741\u670823\u65e5 \/\u7f8e\u901a\u793e\/ &#8212; \u6b4c\u793c\u5236\u836f\u6709\u9650\u516c\u53f8\uff08\u6b4c\u793c\uff0c\u9999\u6e2f\u8054\u4ea4\u6240\u4ee3\u7801\uff1a1672\uff09\u65d7\u4e0b\u5168\u8d44\u5b50\u516c\u53f8\u7518\u83b1\u5236\u836f\u6709\u9650\u516c\u53f8\uff08&quot;\u7518\u83b1&quot;\uff09\u5ba3\u5e03\u5176\u6218\u7565\u5408\u4f5c\u4f19\u4f34Sagimet Biosciences Inc.\uff08Sagimet\uff0c\u7eb3\u65af\u8fbe\u514b\uff1aSGMT\uff09\u4eca\u65e5\u53d1\u5e03\u4e86ASC40\uff08\u5730\u5c3c\u6cd5\u53f8\u4ed6\uff09\u5bf9\u7167\u5b89\u6170\u5242\u6cbb\u7597\u7ecf\u809d\u7a7f\u6d3b\u68c0\u8bc1\u5b9e\u7684\u7ea4\u7ef4\u53162\u671f\u62163\u671f\uff08F2\/F3\uff09\u975e\u9152\u7cbe\u6027\u8102\u80aa\u6027\u809d\u708e\uff08NASH\uff09\u60a3\u8005\u7684FASCINATE-2 IIb\u671f\u4e34\u5e8a\u8bd5\u9a8c\u5728\u7b2c52\u5468\u53d6\u5f97\u7684\u79ef\u6781\u9876\u7ebf\u7ed3\u679c\u3002\u5728\u6b64\u9879\u8bd5\u9a8c\u4e2d\uff0c\u4e0e\u5b89\u6170\u5242\u76f8\u6bd4\uff0c\u53e3\u670d\u9009\u62e9\u6027FASN\u6291\u5236\u5242\u5730\u5c3c\u6cd5\u53f8\u4ed6\u5728\u4e24\u4e2a\u4e3b\u8981\u7ec8\u70b9\uff08NASH\u6539\u5584\u4e14\u7ea4\u7ef4\u5316\u65e0\u6076\u5316\u4e14NAS\u964d\u4f4e\u22652\u5206\uff0c\u4ee5\u53caNAS\u964d\u4f4e\u22652\u5206\u4e14\u7ea4\u7ef4\u5316\u65e0\u6076\u5316\uff09\u8fbe\u5230\u4e86\u7edf\u8ba1\u5b66\u663e\u8457\u6027\u5dee\u5f02\u7684\u6539\u5584\u3002\u4e0e\u5b89\u6170\u5242\u7ec4\u76f8\u6bd4\uff0c\u5730\u5c3c\u6cd5\u53f8\u4ed6\u7ec4\u60a3\u8005\u7684\u7ea4\u7ef4\u5316\u6539\u5584\u22651\u671f\u4e14NASH\u65e0\u6076\u5316\u8fbe\u5230\u4e86\u7edf\u8ba1\u5b66\u663e\u8457\u6027\u5dee\u5f02\uff0c\u78c1\u5171\u632f\u8d28\u5b50\u5bc6\u5ea6\u8102\u80aa\u5206\u6570\uff08MRI-PDFF\uff09\u4e0b\u964d\u226530%\u7684\u5e94\u7b54\u8005\u6bd4\u4f8b\u66f4\u9ad8\u3002 \u57fa\u4e8e\u548cSagimet\u7684\u72ec\u5bb6\u8bb8\u53ef\u534f\u8bae\uff0c\u7518\u83b1\u62e5\u6709ASC40\u5728\u5927\u4e2d\u534e\u533a\u7684\u5f00\u53d1\u3001\u751f\u4ea7\u548c\u5546\u4e1a\u5316\u6743\u76ca\u3002\u6709\u5173\u5ba3\u5e03FASCINATE-2\u7684IIb\u671f\u4e34\u5e8a\u7814\u7a76\u9876\u7ebf\u7ed3\u679c\u65b0\u95fb\u53ef\u89c1\u6b64\u5904\u3002&nbsp; IIb\u671fFASCINATE-2\u9876\u7ebf\u7ed3\u679c\u5730\u5c3c\u6cd5\u53f8\u4ed6\u6cbb\u7597\u7b2c52\u5468\u65f6\uff0c\u4e3b\u8981\u7ec8\u70b9\u548c\u5176\u4ed6\u7ec8\u70b9\u7684\u6539\u5584\u8fbe\u5230\u7edf\u8ba1\u5b66\u663e\u8457\u6027\u5dee\u5f02 \u5730\u5c3c\u6cd5\u53f8\u4ed650\u6beb\u514b(n=81) \u5b89\u6170\u5242(n=45) P\u503c\u5bf9\u6bd4\u5b89\u6170\u5242 \u4e3b\u8981\u7ec8\u70b9 NASH\u6539\u5584\u4e14\u7ea4\u7ef4\u5316\u65e0\u6076\u5316\u4e14NAS\u964d\u4f4e\u22652\u5206 36&nbsp;% 13&nbsp;% 0.002 NAS\u964d\u4f4e\u22652\u5206\u4e14\u7ea4\u7ef4\u5316\u65e0\u6076\u5316 52&nbsp;% 20&nbsp;% 0.0001 \u5176\u4ed6\u7ec8\u70b9 \u7ea4\u7ef4\u5316\u6539\u5584\u22651\u5206\u4e14NASH\u65e0\u6076\u5316 41&nbsp;% 18&nbsp;% 0.005 NASH\u6539\u5584\u4e14\u7ea4\u7ef4\u5316\u65e0\u6076\u5316 38&nbsp;% 16&nbsp;% 0.002 \u4eba\u5de5\u667a\u80fd\u75c5\u7406\u7ea4\u7ef4\u5316\u8bc4\u4f30(qFibrosis)* -0.3 0.1 0.002 ALT\u8f83\u57fa\u7ebf\u53d8\u5316\u7684\u767e\u5206\u6bd4 -30.5&nbsp;% -17.2&nbsp;% 0.03 MRI-PDFF\u5e94\u7b54\u7387** 65&nbsp;% 21&nbsp;% &lt;0.0001 FibroScan AST&hellip; <a class=\"read-more\" href=\"https:\/\/www.xinwengao.com\/cn\/pr\/20240123111200104156\">Read More<\/a><\/p>\n","protected":false},"author":556,"featured_media":0,"comment_status":"close","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1965],"tags":[],"class_list":["post-104156","post","type-post","status-publish","format-standard","hentry","category-partnerships"],"amp_enabled":true,"_links":{"self":[{"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/posts\/104156","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/users\/556"}],"replies":[{"embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/comments?post=104156"}],"version-history":[{"count":1,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/posts\/104156\/revisions"}],"predecessor-version":[{"id":104157,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/posts\/104156\/revisions\/104157"}],"wp:attachment":[{"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/media?parent=104156"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/categories?post=104156"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/tags?post=104156"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}