{"id":102466,"date":"2024-01-08T13:08:00","date_gmt":"2024-01-08T06:08:00","guid":{"rendered":"https:\/\/www.xinwengao.com\/cn\/pr\/20240108130800102466"},"modified":"2024-01-09T00:42:54","modified_gmt":"2024-01-08T16:42:54","slug":"%e5%8d%9a%e5%a5%a5%e4%bf%a1%e5%90%88%e4%bd%9c%e4%bc%99%e4%bc%b4obi-pharma%e5%ae%a3%e5%b8%83trop2-adc%e5%9c%a8%e7%be%8e%e5%9b%bd%e8%8e%b7%e6%89%b9%e4%b8%b4%e5%ba%8a","status":"publish","type":"post","link":"https:\/\/www.xinwengao.com\/cn\/pr\/20240108130800102466","title":{"rendered":"\u535a\u5965\u4fe1\u5408\u4f5c\u4f19\u4f34OBI Pharma\u5ba3\u5e03TROP2 ADC\u5728\u7f8e\u56fd\u83b7\u6279\u4e34\u5e8a"},"content":{"rendered":"

– \u8be5TROP2 ADC\u5c06\u5f00\u5c55\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u8bd5\u9a8c\uff0c\u9884\u8ba1\u4eca\u5e74\u521d\u5c06\u5b8c\u6210\u9996\u4f8b\u60a3\u8005\u7ed9\u836f<\/p>\n

\u5357\u4eac\u548c\u7f8e\u56fd\u7ebd\u74e6\u514b<\/span>2024\u5e741\u67088\u65e5<\/span> \/\u7f8e\u901a\u793e\/ — 2024\u5e741\u67088\u65e5\uff0c\u535a\u5965\u4fe1\u5408\u4f5c\u4f19\u4f34OBI Pharma\uff084174.TWO\uff09\u5ba3\u5e03\u5176\u65b0\u4e00\u4ee3TROP2 \u6297\u4f53\u5076\u8054\u836f\u7269\uff08ADC\uff09OBI-992\uff08\u535a\u5965\u4fe1\u9879\u76ee\u53f7\uff1aBSI-992\uff09\u7684\u4e34\u5e8aI\/II\u671f\u8bd5\u9a8c\u5df2\u83b7\u7f8e\u56fd\u98df\u54c1\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08FDA\uff09\u6279\u51c6\u3002\u7528\u4e8e\u8be5ADC\u5f00\u53d1\u7684\u6297\u4f53\u5206\u5b50\u7531\u535a\u5965\u4fe1\u4e13\u6709\u7684 SynTracer®<\/sup>\u9ad8\u901a\u91cf\u6297\u4f53\u5185\u541e\u7b5b\u9009\u5e73\u53f0\u53d1\u73b0\u548c\u5f00\u53d1\uff0c\u5e76\u4e8e2021\u5e7412\u6708\u6388\u6743\u7ed9OBI Pharma\u3002OBI Pharma\u62e5\u6709OBI-992\uff08BSI-992\uff09\u5728\u4e2d\u56fd\u5927\u9646\u3001\u6fb3\u95e8\u3001\u9999\u6e2f\u4ee5\u5916\u7684\u4ea7\u54c1\u5f00\u53d1\u53ca\u5546\u4e1a\u5316\u6743\u5229\uff0c\u535a\u5965\u4fe1\u4fdd\u7559\u4e2d\u56fd\u5927\u9646\u3001\u6fb3\u95e8\u3001\u9999\u6e2f\u7684\u6743\u5229\u3002<\/p>\n

"\u6211\u4eec\u5f88\u9ad8\u5174\u5408\u4f5c\u4f19\u4f34OBI Pharma\u5728\u7f8e\u56fd\u83b7\u5f97OBI-992\uff08BSI-992\uff09\u7684\u4e34\u5e8a\u8bd5\u9a8c\u6279\u51c6\uff0c"\u9996\u5e2d\u5546\u52a1\u548c\u5f00\u53d1\u5b98\uff0c\u535a\u5965\u4fe1\u7f8e\u56fd\u5206\u516c\u53f8\u603b\u88c1Hugh Davis\u535a\u58eb\u8868\u793a\u3002"\u4e34\u5e8a\u524d\u7814\u7a76\u6570\u636e\u663e\u793a\uff0c\u5bf9\u6bd4\u5176\u4ed6TROP2 ADC\uff0cOBI-992\u5177\u6709\u5dee\u5f02\u5316\u4f18\u52bf\u3002\u8fd9\u4e5f\u8868\u660e\u535a\u5965\u4fe1SynTracer®<\/sup>\u9ad8\u901a\u91cf\u6297\u4f53\u5185\u541e\u7b5b\u9009\u5e73\u53f0\u5728\u53d1\u73b0\u9002\u7528\u4e8e\u65b0\u578bADC\u7597\u6cd5\u7684\u6297\u4f53\u65b9\u9762\u5177\u5907\u72ec\u7279\u4f18\u52bf\u3002\u6211\u4eec\u671f\u5f85\u8be5\u836f\u7269\u5728\u672a\u6765\u80fd\u4e3a\u5168\u7403\u60a3\u8005\u5e26\u6765\u65b0\u7684\u6cbb\u7597\u65b9\u6848\u3002"<\/p>\n

OBI-992\u4e34\u5e8a\u8bd5\u9a8c\u8ba1\u5212\u4ee5\u665a\u671f\u5b9e\u4f53\u7624\u60a3\u8005\u4e3a\u6536\u6cbb\u5bf9\u8c61\uff0c\u5305\u62ec\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff08NSCLC\uff09\u3001\u5c0f\u7ec6\u80de\u80ba\u764c\uff08SCLC\uff09\u3001\u80c3\u764c\uff08GC\uff09\uff0c\u53ca\u5176\u4ed6\u6570\u79cd\u764c\u75c7\u75c5\u60a3\u4ea6\u5217\u4e3a\u6f5c\u5728\u76ee\u6807\u3002OBI Pharma\u9996\u5e2d\u533b\u5b66\u5b98Wayne Saville\u535a\u58eb\u6307\u51fa\uff0c\u8fd9\u9879\u8bd5\u9a8c\u65e8\u5728\u8bc4\u4f30OBI-992\u5b89\u5168\u6027\u3001\u836f\u4ee3\u52a8\u529b\u5b66\u548c\u521d\u6b65\u7597\u6548\uff0c\u4ed6\u76f8\u4fe1OBI-992\u5177\u6709\u76f8\u5f53\u6f5c\u529b\u53d1\u5c55\u4e3a\u540c\u7c7b\u6700\u4f73\uff08best-in-class\uff09\u7684TROP2 ADC\uff0c\u9884\u8ba1I\/II\u671f\u8bd5\u9a8c\u5c06\u4e8e2024\u5e74\u521d\u5c55\u5f00\uff0c\u5e76\u4e3a\u9996\u4f4d\u60a3\u8005\u7ed9\u836f\u3002<\/p>\n

OBI Pharma\u9996\u5e2d\u6267\u884c\u5b98\u738b\u6167\u541b\u535a\u58eb\u4e5f\u8868\u793a\uff0c"OBI-992\u662f\u7531\u6d69\u9f0e\u81ea\u884c\u8bbe\u8ba1\u3001\u5236\u9020\u7684\u65b0\u578bTROP2 ADC\uff0c\u4e0e\u5176\u4ed6TROP2 ADC\u76f8\u6bd4\uff0c\u5b83\u5728\u8bb8\u591a\u4e34\u5e8a\u524d\u8bd5\u9a8c\u4e2d\u90fd\u663e\u73b0\u51fa\u8272\u7684\u7597\u6548\u3001\u826f\u597d\u7684\u5b89\u5168\u6027\u548c\u9ad8\u7a33\u5b9a\u6027\uff1b\u6211\u4eec\u5bf9OBI-992\u9996\u5ea6\u8fdb\u5165\u4eba\u4f53\u4e34\u5e8a\u8bd5\u9a8c\u611f\u5230\u5174\u594b\uff0cOBI Pharma\u5c06\u4ee5\u300e\u6025\u75c5\u4eba\u4e4b\u6240\u6025\u300f\u539f\u5219\uff0c\u5feb\u901f\u5c06\u6709\u6f5c\u529b\u7684\u764c\u75c7\u7597\u6cd5\u63a8\u8fdb\u4e34\u5e8a\u3002"<\/p>\n

\u5173\u4e8eOBI-992<\/b>\uff08BSI-992<\/b>\uff09<\/b><\/p>\n

OBI-992\uff08BSI-992\uff09\u662f\u4ee5TROP2\u4e3a\u9776\u70b9\u6240\u8bbe\u8ba1\u7684\u6297\u4f53\u5076\u8054\u836f\u7269\uff08Antibody Drug Conjugate; ADC\uff09\u3002TROP2\u5728\u591a\u79cd\u5b9e\u4f53\u80bf\u7624\u90fd\u6709\u9ad8\u5ea6\u8868\u8fbe\uff0c\u5305\u62ec\u80ba\u764c\u3001\u4e73\u764c\u3001\u5375\u5de2\u764c\u3001\u80c3\u764c\u7b49\u4e0d\u540c\u764c\u75c7\uff0c\u56e0\u6b64\u88ab\u8ba4\u4e3a\u662f\u4f18\u79c0\u7684\u764c\u75c7\u6cbb\u7597\u9776\u70b9\u3002<\/p>\n

OBI-992\uff08BSI-992\uff09\u4ee5\u8fde\u63a5\u5b50\uff08linker\uff09\u5c06\u6297\u4f53\u548c\u5f3a\u6548\u7684TOP1\uff08topoisomerase I\uff09\u6291\u5236\u5242\u76f8\u7ed3\u5408\uff0c\u8fd9\u4e2a\u72ec\u7279\u7684\u8fde\u63a5\u5b50\u5177\u6709\u9ad8\u5ea6\u4eb2\u6c34\u6027\uff0c\u5fc5\u987b\u7531\u764c\u7ec6\u80de\u5185\u7684\u9176\u88c2\u89e3\uff0c\u4ece\u800c\u91ca\u653e\u836f\u7269\u3002OBI-992\uff08BSI-992\uff09\u5728\u8840\u6db2\u4e2d\u7ef4\u6301\u7a33\u5b9a\uff0c\u4e00\u65e6\u4e0e\u764c\u7ec6\u80de\u8868\u9762\u7684TROP2\u7ed3\u5408\u5185\u541e\uff0c\u5c31\u4f1a\u5728\u764c\u7ec6\u80de\u5185\u91ca\u653e\u5c0f\u5206\u5b50\u836f\u7269\uff0c\u6bd2\u6740\u764c\u7ec6\u80de\u3002\u591a\u79cd\u52a8\u7269\u6a21\u578b\u5df2\u7ecf\u5145\u5206\u663e\u793a\uff0cOBI-992\uff08BSI-992\uff09\u5177\u6709\u9ad8\u6548\u7684\u6297\u80bf\u7624\u6d3b\u6027\uff0c\u4f18\u5f02\u7684\u836f\u4ee3\u52a8\u529b\u5b66\u8868\u73b0\uff0c\u548c\u826f\u597d\u7684\u5b89\u5168\u6027\u3002<\/p>\n

TROP2\u6297\u4f53\u4e3a\u535a\u5965\u4fe1\u53d1\u73b0\u5e76\u5f00\u53d1\uff0c2021\u5e7412\u6708\u6388\u6743\u7ed9OBI Pharma\u3002OBI Pharma\u8d1f\u8d23ADC\u6784\u5efa\u3001\u7814\u53d1\uff0c\u5e76\u62e5\u6709\u4e2d\u56fd\u5927\u9646\u3001\u9999\u6e2f\u3001\u6fb3\u95e8\u4ee5\u5916\u7684\u5546\u4e1a\u5316\u6743\u5229\u3002<\/p>\n

\u5173\u4e8eOBI Pharma<\/b><\/p>\n

\u53f0\u6e7e\u6d69\u9f0e\u751f\u6280\uff08OBI Pharma, Inc.\uff09\u6210\u7acb\u4e8e 2002\u5e74\uff0c\u662f\u4e00\u5df2\u53d1\u5c55\u5230\u4e34\u5e8a\u9636\u6bb5\u7684\u764c\u75c7\u533b\u836f\u516c\u53f8\uff0c\u4ee5\u6ee1\u8db3\u8fd8\u672a\u6709\u6548\u533b\u7597\u7684\u9700\u6c42\u4e3a\u4f7f\u547d\uff0c\u81f4\u529b\u4e8e\u5f00\u53d1\u764c\u75c7\u6cbb\u7597\u7684\u65b0\u836f\u4e0e\u591a\u5143\u5316\u6cbb\u7597\u7ec4\u5408\u3002\u53f0\u6e7e\u6d69\u9f0e\u9488\u5bf9Globo H\u6240\u5f00\u53d1\u7684\u9996\u521b\u578b\uff08first-in-class\uff09\u514d\u75ab\u7597\u6cd5\u65b0\u836f\u4ea7\u54c1\u7ec4\u5408\uff0c\u5305\u62ec\u4e24\u79cd\u4ee5Globo H\u4e3a\u6807\u7684\u4e4b\u4e3b\u52a8\u514d\u75ab\u7597\u6cd5\u75ab\u82d7Adagloxad Simolenin\uff08\u53c8\u79f0OBI-822\uff09\u548cOBI-833\u3002\u53e6\u5916\uff0c\u8be5\u516c\u53f8\u5229\u7528\u72ec\u7279\u7684ADC\u5e73\u53f0\uff0c\u5305\u62ecGlycOBI™\uff0c\u5f00\u521b\u4e86\u591a\u6837\u6027ADC\u65b0\u836f\u4ea7\u54c1\u7ebf\uff0c\u5982\u4ee5TROP2\u4e3a\u6807\u9776\u7684OBI-992\u3001OBI-902\u3001\u4ee5Nectin4\u4e3a\u6807\u9776\u7684OBI-904\u548c\u4ee5HER2\u4e3a\u6807\u9776\u5f00\u53d1\u7684OBI-905\u3002<\/p>\n

\u6b64\u5916\uff0c\u6d69\u9f0e\u4ea7\u54c1\u7ebf\u8fd8\u5305\u62ec\u9996\u521b\u5c0f\u5206\u5b50\u524d\u9a71\u836fOBI-3424\u3002\u5b83\u7cfb\u4ee5\u919b\u916e\u8fd8\u539f\u9176AKR1C3\u4e3a\u6807\u9776\u7684\u5c0f\u5206\u5b50\u524d\u9a71\u836f\uff0cAKR1C3\u53ef\u5c06\u539f\u672c\u6d3b\u6027\u6781\u4f4e\u7684\u524d\u9a71\u836f\uff0c\u6d3b\u5316\u4e3a\u5177\u6709\u7597\u6548\u7684DNA\u70f7\u5316\u5242\uff08DNA alkylating agent\uff09\u6297\u80bf\u7624\u836f\u7269\u3002\u6b32\u8fdb\u4e00\u6b65\u4e86\u89e3\u53f0\u6e7e\u6d69\u9f0e\u76f8\u5173\u4fe1\u606f\uff0c\u8bf7\u4e0a\u5b98\u7f51www.obipharma.com<\/a>\u3002<\/p>\n

\u5173\u4e8e\u535a\u5965\u4fe1<\/b><\/p>\n

\u535a\u5965\u4fe1\u662f\u4e00\u5bb6\u5904\u4e8e\u4e34\u5e8a\u9636\u6bb5\u7684\u5168\u7403\u5316\u521b\u65b0\u751f\u7269\u6280\u672f\u516c\u53f8\uff0c\u81f4\u529b\u4e8e\u5e94\u7528\u5176\u4e13\u6709\u7684\u6297\u4f53\u6280\u672f\u5e73\u53f0\u5f00\u53d1\u521b\u65b0\u7597\u6cd5\uff0c\u4f7f\u60a3\u8005\u5728\u514d\u75ab\u53ca\u80bf\u7624\u75be\u75c5\u7684\u6cbb\u7597\u4e2d\u83b7\u76ca\u3002\u6210\u7acb\u4e8e2017\u5e74\uff0c\u535a\u5965\u4fe1\u901a\u8fc7\u5185\u90e8\u4e13\u6709\u7684H³\uff08\u9ad8\u901a\u91cf\uff0c\u9ad8\u542b\u91cf\uff0c\u9ad8\u6548\u7387\uff09\u6297\u4f53\u53d1\u73b0\u5e73\u53f0\u3001SynTracer®<\/sup> \u9ad8\u901a\u91cf\u6297\u4f53\u5185\u541e\u7b5b\u9009\u5e73\u53f0\u3001Flexibody®<\/sup> \u53cc\u529f\u80fd\u6297\u4f53\u6280\u672f\u5e73\u53f0\u53ca\u5168\u7403\u5408\u4f5c\u5efa\u7acb\u4e86\u4e00\u7cfb\u5217\u521b\u65b0\u836f\u7269\u7ba1\u7ebf\u3002\u81ea\u7814\u4ea7\u54c1Bosakitug\uff08BSI-045B\/TQC2731\uff0c\u6297TSLP\u5355\u6297\uff09\u6b63\u5728\u4e2d\u7f8e\u5f00\u5c55\u9488\u5bf9\u4e25\u91cd\u54ee\u5598\u3001\u6162\u6027\u9f3b\u7aa6\u708e\u4f34\u9f3b\u606f\u8089\u548c\u7279\u5e94\u6027\u76ae\u708e\u7684\u4e34\u5e8aII\u671f\u8bd5\u9a8c\uff0c\u53e6\u67095\u9879\u81ea\u7814\u5408\u4f5c\u4ea7\u54c1\u5728\u4e2d\u7f8e\u5f00\u5c55\u4e34\u5e8aI\u671f\u6216II\u671f\u8bd5\u9a8c\u3002\u66f4\u591a\u516c\u53f8\u53ca\u7ba1\u7ebf\u4fe1\u606f\uff0c\u8bf7\u8bbf\u95eewww.biosion.com<\/a>\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"

– \u8be5TROP2 ADC\u5c06\u5f00\u5c55\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u8bd5\u9a8c\uff0c\u9884\u8ba1\u4eca\u5e74\u521d\u5c06\u5b8c\u6210\u9996\u4f8b\u60a3\u8005\u7ed9\u836f \u5357\u4eac\u548c\u7f8e\u56fd\u7ebd\u74e6\u514b2024\u5e741\u67088\u65e5 \/\u7f8e\u901a\u793e\/ — 2024\u5e741\u67088\u65e5\uff0c\u535a\u5965\u4fe1\u5408\u4f5c\u4f19\u4f34OBI Pharma\uff084174.TWO\uff09\u5ba3\u5e03\u5176\u65b0\u4e00\u4ee3TROP2 \u6297\u4f53\u5076\u8054\u836f\u7269\uff08ADC\uff09OBI-992\uff08\u535a\u5965\u4fe1\u9879\u76ee\u53f7\uff1aBSI-992\uff09\u7684\u4e34\u5e8aI\/II\u671f\u8bd5\u9a8c\u5df2\u83b7\u7f8e\u56fd\u98df\u54c1\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08FDA\uff09\u6279\u51c6\u3002\u7528\u4e8e\u8be5ADC\u5f00\u53d1\u7684\u6297\u4f53\u5206\u5b50\u7531\u535a\u5965\u4fe1\u4e13\u6709\u7684 SynTracer®\u9ad8\u901a\u91cf\u6297\u4f53\u5185\u541e\u7b5b\u9009\u5e73\u53f0\u53d1\u73b0\u548c\u5f00\u53d1\uff0c\u5e76\u4e8e2021\u5e7412\u6708\u6388\u6743\u7ed9OBI Pharma\u3002OBI 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