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2b\u671f\u4e34\u5e8a\u7814\u7a76\uff0803\u8bd5\u9a8c\uff09\u662f\u4e00\u9879\u968f\u673a\u3001\u5b89\u6170\u5242\u5bf9\u7167\u8bd5\u9a8c\uff0c\u65e8\u5728\u8bc4\u4f30\u6ce8\u5c04150\u5929\u5185\u5c3c\u585e\u97e6\u5355\u6297\u5bf9\u9700\u533b\u7597\u5c31\u8bca\u7684\u4e0b\u547c\u5438\u9053\u611f\u67d3\uff08LRTI\uff09\u7684\u4fdd\u62a4\u6548\u679c\u3002\u5728\u8fd9\u9879\u7814\u7a76\u4e2d\uff0c\u80ce\u9f8429\u81f335\u5468\u4ee5\u5185\u7684\u5065\u5eb7\u65e9\u4ea7\u513f\u88ab\u968f\u673a\u5206\u914d\uff082:1\uff09\u63a5\u53d7\u5355\u524250mg\u5c3c\u585e\u97e6\u5355\u6297\u6216\u5b89\u6170\u5242\u808c\u8089\u6ce8\u5c04\uff08\u65e0\u8bba\u4f53\u91cd\u5982\u4f55\uff09\u3002[4,9]<\/span><\/sup><\/p>\n

\u6839\u636e\u5bf92b\u671f\u7814\u7a76\u6570\u636e\u7684\u8fdb\u4e00\u6b65\u63a2\u7d22\u786e\u5b9a\u4e86\u5c3c\u585e\u97e6\u5355\u6297\u7684\u7ed9\u836f\u65b9\u6848\uff0c\u5e76\u5e94\u7528\u4e8e\u968f\u540e\u7684\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u3002\u5728\u968f\u540e\u7684\u8bd5\u9a8c\u91cc\uff0c\u4f53\u91cd\u4f4e\u4e8e5kg\u7684\u53d7\u8bd5\u8005\u5355\u5242\u6b21\u6ce8\u5c04\u5242\u91cf\u4e3a50mg\uff0c\u4f53\u91cd\u8fbe5kg\u6216\u4ee5\u4e0a\u7684\u53d7\u8bd5\u8005\u5355\u5242\u6b21\u6ce8\u5c04\u5242\u91cf\u4e3a100mg\u3002[4,9]<\/span><\/sup><\/p>\n

3\u671fMELODY\u7814\u7a76\uff0804\u8bd5\u9a8c\uff09\u662f\u4e00\u9879\u572821\u4e2a\u56fd\u5bb6\u8fdb\u884c\u7684\u968f\u673a\u3001\u53cc\u76f2\u3001\u5b89\u6170\u5242\u5bf9\u7167\u8bd5\u9a8c\uff0c\u65e8\u5728\u8bc4\u4f30\u6ce8\u5c04\u5c3c\u585e\u97e6\u5355\u6297\u540e150\u5929\u5185\u5bf9\u6bd4\u5b89\u6170\u5242\uff0c\u5728\u8fdb\u5165\u7b2c\u4e00\u4e2aRSV\u611f\u67d3\u5b63\u7684\u5065\u5eb7\u8db3\u6708\u548c\u665a\u671f\u65e9\u4ea7\u513f\uff08\u80ce\u9f84\u226535\u5468\uff09\u4e2d\u9884\u9632\u9700\u8981\u533b\u7597\u5c31\u8bca\u7684\u4e0b\u547c\u5438\u9053\u611f\u67d3\uff08LRTI\uff09\u7684\u6709\u6548\u6027\u3002[2,3,9]<\/sup><\/p>\n

MEDLEY\u7814\u7a76\uff0805\u8bd5\u9a8c\uff09\u662f\u4e00\u9879\u968f\u673a\u3001\u53cc\u76f2\u3001\u4ee5\u5e15\u5229\u73e0\u5355\u6297\u4e3a\u5bf9\u7167\u76842\/3\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u4e3b\u8981\u76ee\u6807\u662f\u8bc4\u4f30\u5c3c\u585e\u97e6\u5355\u6297\u5728\u7b26\u5408\u63a5\u53d7\u5e15\u5229\u73e0\u5355\u6297\u6cbb\u7597\u7684\u80ce\u9f84\u5c0f\u4e8e35\u5468\u7684\u65e9\u4ea7\u513f\u548c\u5148\u5929\u6027\u5fc3\u810f\u75c5\uff08CHD\uff09\u548c\/\u6216\u6162\u6027\u80ba\u75c5\uff08CLD\uff09\u5a74\u513f\u4e2d\u7684\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\u30022019\u5e747\u6708\u81f32021\u5e745\u6708\u671f\u95f4\uff0c925\u540d\u8fdb\u5165\u7b2c\u4e00\u4e2aRSV\u611f\u67d3\u5b63\u7684\u5a74\u513f\u88ab\u968f\u673a\u5206\u914d\u63a5\u53d7\u5c3c\u585e\u97e6\u5355\u6297\u6216\u5e15\u5229\u73e0\u5355\u6297\u3002\u7528\u836f\u540e360\u5929\u5185\uff0c\u901a\u8fc7\u76d1\u6d4b\u6cbb\u7597\u671f\u95f4\u51fa\u73b0\u7684\u4e0d\u826f\u4e8b\u4ef6\u53d1\u751f\u7387\u6765\u8bc4\u4f30\u5b89\u5168\u6027\u3002\u8be5\u7814\u7a76\u4e2d\uff0c\u5c3c\u585e\u97e6\u5355\u6297\u7684\u8840\u6e05\u6c34\u5e73\uff08\u7b2c151\u5929\uff09\u4e0e3\u671fMELODY\u4e34\u5e8a\u8bd5\u9a8c\u7684\u7ed3\u679c\u76f8\u5f53\uff0c\u8868\u660e\u5c3c\u585e\u97e6\u5355\u6297\u5728\u8be5\u7c7b\u4eba\u7fa4\u4e2d\u7684\u4fdd\u62a4\u6548\u679c\u53ef\u80fd\u4e0e\u5065\u5eb7\u8db3\u6708\u513f\u548c\u665a\u671f\u65e9\u4ea7\u513f\u76f8\u4f3c\u3002\u76f8\u5173\u7814\u7a76\u7ed3\u679c\u4e8e2022\u5e743\u6708\u53d1\u8868\u5728\u65b0\u82f1\u683c\u5170\u533b\u5b66\u6742\u5fd7\uff08New England Journal of Medicine\uff0cNEJM\uff09<\/a>\u4e0a\u3002[5,9]<\/sup> <\/p>\n

\u57282\/3\u671fMEDLEY\u8bd5\u9a8c\u4e2d\uff0c\u5c3c\u585e\u97e6\u5355\u6297\u7684\u5b89\u5168\u6027\u4e0e\u5e15\u5229\u73e0\u5355\u6297\u76f8\u4f3c\uff0c\u540c\u65f6\u4e0eMELODY\u548c2b\u671f\u8bd5\u9a8c\u4e2d\u7814\u7a76\u7684\u5065\u5eb7\u8db3\u6708\u513f\u4e0e\u65e9\u4ea7\u513f\u7684\u5b89\u5168\u6027\u4fdd\u6301\u4e00\u81f4\u3002\u7814\u7a76\u4e2d\u5076\u89c1\u4e0d\u826f\u53cd\u5e94\uff0c\u62a5\u544a\u6700\u591a\u7684\u4e0d\u826f\u53cd\u5e94\u5305\u62ec\u7ed9\u836f\u540e14\u5929\u5185\u51fa\u73b0\u76ae\u75b9\uff08\u5927\u591a\u6570\u4e3a\u8f7b\u4e2d\u5ea6\uff09\uff1b\u4ee5\u53ca\u7ed9\u836f\u540e7\u5929\u5185\u51fa\u73b0\u975e\u4e25\u91cd\u7684\u6ce8\u5c04\u90e8\u4f4d\u53cd\u5e94\u3002[<\/sup>2,3,5,9]<\/sup> <\/p>\n

MELODY\u30012\/3\u671fMEDLEY\u548c2b\u671f\u8bd5\u9a8c\u7ed3\u679c\u8868\u660e\uff0c\u5355\u5242\u6b21\u5c3c\u585e\u97e6\u5355\u6297\u6709\u52a9\u4e8e\u5728\u7b2c\u4e00\u4e2aRSV\u611f\u67d3\u5b63\u4fdd\u62a4\u5a74\u513f\u514d\u53d7RSV\u611f\u67d3\u7684\u4fb5\u5bb3\u3002\u8fd9\u4e9b\u8bd5\u9a8c\u6db5\u76d6\u4e86\u5e7f\u6cdb\u7684\u5a74\u513f\u7fa4\u4f53\uff0c\u5305\u62ec\uff1a\u5065\u5eb7\u8db3\u6708\u513f\u3001\u665a\u671f\u65e9\u4ea7\u513f\u548c\u65e9\u4ea7\u513f\uff0c\u4ee5\u53ca\u6709\u7279\u6b8a\u5065\u5eb7\u72b6\u51b5\u6613\u60a3\u4e25\u91cdRSV\u611f\u67d3\u7684\u5a74\u513f\u3002[<\/sup>2-5,9]<\/sup><\/p>\n

\u57fa\u4e8e\u8fd9\u4e9b\u8bd5\u9a8c\u7ed3\u679c\uff0c\u516c\u53f8\u4e8e2022\u5e74\u8d77\u5728\u5168\u7403\u5404\u5730\u9646\u7eed\u9012\u4ea4\u4ea7\u54c1\u4e0a\u5e02\u7533\u8bf7\u3002<\/p>\n

\u5173\u4e8e<\/b>3<\/b>\u671f<\/b>MELODY<\/b>\u7814\u7a76\uff08<\/b>04<\/b>\u8bd5\u9a8c\uff09\u7684\u7ed3\u679c<\/b><\/p>\n

3\u671fMELODY\u7814\u7a76\u5df2\u8fbe\u5230\u4e3b\u8981\u7ec8\u70b9\uff1a\u4e0e\u5b89\u6170\u5242\u76f8\u6bd4\uff0c\u5c3c\u585e\u97e6\u5355\u6297\u4f7fRSV\u5f15\u8d77\u7684LRTI\uff08\u5982\u6bdb\u7ec6\u652f\u6c14\u7ba1\u708e\u6216\u80ba\u708e\uff09\u5c31\u8bca\u7387\u964d\u4f4e\u4e8674.9% (95% CI 50.6, 87.3; P<0.001) [3]<\/sup>\uff0c\u6cbb\u7597\u7ec4\u89c2\u5bdf\u5230\u7684\u4e8b\u4ef6\u53d1\u751f\u7387\u4e3a1.2%\uff0c\u5b89\u6170\u5242\u7ec4\u4e3a5%\u3002\u5728\u6b21\u8981\u7ec8\u70b9\u4e0a\uff0c\u5c3c\u585e\u97e6\u5355\u6297\u9884\u9632\u4f4f\u9662\u7684\u6709\u6548\u7387\u4e3a60.2%\uff0895% CI\uff1a-14.6, 86.2\uff09\uff0c\u6cbb\u7597\u7ec4\u89c2\u5bdf\u5230\u7684\u4e8b\u4ef6\u53d1\u751f\u7387\u4e3a0.6%\uff0c\u5b89\u6170\u5242\u7ec4\u4e3a1.6%\u30022019\u5e747\u6708\u81f32020\u5e743\u6708\u671f\u95f4\uff0c1490\u540d\u5a74\u513f\u5728RSV\u611f\u67d3\u5b63\u5f00\u59cb\u65f6\u88ab\u968f\u673a\u5206\u914d\u63a5\u53d7\u5c3c\u585e\u97e6\u5355\u6297\u6216\u5b89\u6170\u5242\u3002MELODY\u7814\u7a76\u4e3b\u961f\u5217\u7684\u521d\u59cb\u6570\u636e\u4e8e2022\u5e743\u6708\u53d1\u8868\u5728\u65b0\u82f1\u683c\u5170\u533b\u5b66<\/a>\u6742\u5fd7<\/a>\u4e0a\u3002[<\/sup>3]<\/sup><\/p>\n

\u5173\u4e8e<\/b>2b<\/span><\/b>\u671f\u4e34\u5e8a\u7814\u7a76\uff08<\/b>03<\/b>\u8bd5\u9a8c\uff09\u7684\u7ed3\u679c<\/b><\/p>\n

2b\u671f\u4e34\u5e8a\u7814\u7a76\u5df2\u8fbe\u5230\u4e3b\u8981\u7ec8\u70b9\uff1a\u4e0e\u5b89\u6170\u5242\u76f8\u6bd4\uff0c\u5c3c\u585e\u97e6\u5355\u6297\u4f7fRSV LRTI\u5c31\u8bca\u7387\u964d\u4f4e\u4e8670.1% (95% CI: 52.3, 81.2)\uff0c\u6cbb\u7597\u7ec4\u89c2\u5bdf\u5230\u7684\u4e8b\u4ef6\u53d1\u751f\u7387\u4e3a2.6%\uff0c\u5b89\u6170\u5242\u7ec4\u4e3a9.5%\u30022016\u5e7411\u6708\u81f32017\u5e7412\u6708\u671f\u95f4\uff0c1453\u540d\u5a74\u513f\u5728RSV\u611f\u67d3\u5b63\u5f00\u59cb\u65f6\u88ab\u968f\u673a\u5206\u914d\u63a5\u53d7\u5c3c\u585e\u97e6\u5355\u6297\uff08n=969\uff09\u6216\u5b89\u6170\u5242\uff08n=484\uff09\u3002\u963f\u65af\u5229\u5eb7\u5728\u5357\u5317\u534a\u7403\u517123\u4e2a\u56fd\u5bb6\u7684164\u4e2a\u7814\u7a76\u4e2d\u5fc3\u5f00\u5c55\u4e86\u8fd9\u9879\u7814\u7a76\u3002\u7814\u7a76\u6570\u636e\u4e8e2020\u5e747\u6708\u53d1\u8868\u5728\u65b0\u82f1\u683c\u5170\u533b\u5b66\u6742\u5fd7<\/a>\u4e0a\u3002[<\/sup>4]<\/sup> <\/p>\n

\u5728\u9884\u5148\u8bbe\u5b9a\u7684\u6b21\u8981\u7ec8\u70b9\u4e0a\uff0c\u4e0e\u5b89\u6170\u5242\u76f8\u6bd4\uff0c\u5c3c\u585e\u97e6\u5355\u6297\u5c06\u9700\u8981\u4f4f\u9662\u7684RSV LRTI\u5c31\u8bca\u7387\u964d\u4f4e\u4e8678.4%\uff0895% CI 51.9,90.3\uff09\u3002\u6cbb\u7597\u7ec4\u89c2\u5bdf\u5230\u7684\u4e8b\u4ef6\u53d1\u751f\u7387\u4e3a0.8%\uff0c\u5b89\u6170\u5242\u7ec4\u4e3a4.1%\u3002\u6839\u636e\u4e00\u9879\u9488\u5bf92b\u671f\u7814\u7a76\u7684\u4e8b\u540e\u5206\u6790\uff08\u5728\u4f53\u91cd\u5c0f\u4e8e5\u516c\u65a4\u7684\u5a74\u513f\u4e9a\u7ec4\u4e2d\u5e94\u7528\u63a8\u8350\u768450mg\u5242\u91cf\uff09\uff0c\u5c3c\u585e\u97e6\u5355\u6297\u9884\u9632\u9700\u8981\u5c31\u8bca\u7684RSV LRTI\u548c\u9700\u8981\u5c31\u8bca\u5408\u5e76\u4f4f\u9662\u7684RSV LRTI\u7684\u6709\u6548\u6027\u5206\u522b\u4e3a86.2%\uff0895% CI 68.0, 94.0\uff09\u548c86.5%\uff0895% CI 53.5, 96.1\uff09\u3002[<\/sup>4]<\/sup> <\/p>\n

\u5173\u4e8e<\/b>\u5c3c\u585e\u97e6\u5355\u6297<\/b><\/p>\n

\u5c3c\u585e\u97e6\u5355\u6297\uff08Nirsevimab \u5c3c\u585e\u97e6\u5355\u6297\uff09\u662f\u4e00\u79cd\u5355\u5242\u6b21\u957f\u6548\u6297\u4f53\uff0c\u7531\u963f\u65af\u5229\u5eb7\u548c\u8d5b\u8bfa\u83f2\u5229\u7528\u963f\u65af\u5229\u5eb7\u7684YTE\u6280\u672f\u5171\u540c\u5f00\u53d1\u4e0e\u5546\u4e1a\u5316\u3002\u8be5\u836f\u54c1\u65e8\u5728\u4fdd\u62a4\u5373\u5c06\u8fdb\u5165\u6216\u51fa\u751f\u5728\u7b2c\u4e00\u4e2a\u547c\u5438\u9053\u5408\u80de\u75c5\u6bd2\uff08RSV\uff09\u611f\u67d3\u5b63\u7684\u65b0\u751f\u513f\u548c\u5a74\u513f\uff0c\u4ee5\u53ca24\u4e2a\u6708\u4ee5\u4e0b\u5728\u7b2c\u4e8c\u4e2aRSV\u611f\u67d3\u5b63\u4ecd\u6613\u60a3\u4e25\u91cdRSV\u75be\u75c5\u7684\u5a74\u513f\u3002\u5c3c\u585e\u97e6\u5355\u6297\u901a\u8fc7\u5355\u5242\u6b21\u5f62\u5f0f\u4e3a\u65b0\u751f\u513f\u548c\u5a74\u513f\u63d0\u4f9b\u5feb\u901f\u7684RSV\u4fdd\u62a4\uff0c\u4ee5\u5e2e\u52a9\u9884\u9632\u7531RSV\u5f15\u8d77\u7684\u4e0b\u547c\u5438\u9053\u75be\u75c5\uff0c\u800c\u65e0\u9700\u6fc0\u6d3b\u514d\u75ab\u7cfb\u7edf\u3002<\/p>\n

\u5c3c\u585e\u97e6\u5355\u6297\u7684\u7ed9\u836f\u65f6\u95f4\u53ef\u8bbe\u7f6e\u4e3aRSV\u611f\u67d3\u5b63\u5f00\u59cb\u65f6\u3002[10]<\/sup><\/p>\n

\u5c3c\u585e\u97e6\u5355\u6297\u5df2\u83b7\u5f97\u5168\u7403\u591a\u4e2a\u4e3b\u8981\u76d1\u7ba1\u673a\u6784\u6388\u4e88\u7684\u76f8\u5173\u8d44\u683c\u8ba4\u5b9a\uff0c\u4ee5\u52a0\u901f\u5176\u4e34\u5e8a\u5f00\u53d1\uff0c\u5176\u4e2d\u5305\u62ec\u4e2d\u56fd\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08NMPA\uff09\u4e0b\u5c5e\u836f\u54c1\u5ba1\u8bc4\u4e2d\u5fc3\u6388\u4e88\u7684\u7a81\u7834\u6027\u7597\u6cd5\u8ba4\u5b9a\u548c\u4f18\u5148\u5ba1\u8bc4\u8d44\u683c\u3001\u7f8e\u56fdFDA\u6388\u4e88\u7684\u7a81\u7834\u6027\u7597\u6cd5\u8ba4\u5b9a<\/a>\u3001\u6b27\u6d32\u836f\u54c1\u7ba1\u7406\u5c40\uff08EMA\uff09\u6388\u4e88\u7684\u4f18\u5148\u836f\u7269\u8d44\u683c<\/a>\uff08PRIME\uff09\u3001\u4ee5\u53ca\u88ab\u65e5\u672c\u533b\u5b66\u7814\u7a76\u5f00\u53d1\u7f72\uff08AMED\uff09\u9009\u4e3a"\u4fc3\u8fdb\u513f\u79d1\u65b0\u836f\u5f00\u53d1\u7684\u836f\u7269\u9074\u9009\u7814\u7a76\u8ba1\u5212"\u4e2d\u7684"\u4f18\u5148\u5f00\u53d1\u836f\u7269"\u3002<\/p>\n

\u5173\u4e8e\u4e0e\u8d5b\u8bfa\u83f2\u7684\u5408\u4f5c<\/b><\/p>\n

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*\uff1a\u622a\u6b62\u52302024\u5e741\u67082\u65e5<\/p>\n

\n\n\n\n\n\n\n\n\n\n\n\n\n
\n

[1] \u4e50\u552f\u521d®\u836f\u54c1\u8bf4\u660e\u4e66<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

[2] Muller WJ, et al. Nirsevimab for Prevention of RSV in Term and Late-Preterm Infants. N Engl J Med. April 5, 2023. DOI: 10.1056\/NEJMc2214773<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

[3] Hammitt LL, et al. Nirsevimab for Prevention of RSV in Healthy Late-Preterm and Term Infants. N Engl J Med. 2022;386 (9): 837-846. Doi: 10.1056\/NEJMoa2110275<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

[4] Griffin P, MD et al. Single-Dose Nirsevimab for Prevention of RSV in Preterm Infants. N Engl J Med. 2020;383: 415-425. DOI: 10.1056\/NEJMoa1913556<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

[5] Domachowske J, MD et al. Safety of Nirsevimab for RSV in Infants with Heart or Lung Disease or Prematurity. N Engl J Med. 2022; 386 (9)<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

[6] Ren SHL, et al. Influenza Other Respi Viruses. 2022; 16:789\u2013799<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

[7] Gong L, et al. Risk Manag Healthc Policy. 2021; 14:1525-1531<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

[8] Rah B, et al. Respiratory Syncytial Virus-Associated Hospitalizations Among Young Children: 2015-2016. Pediatrics. 2020;146:e20193611.<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

[9] US FDA. Beyfortus (nirsevimab-alip) Prescribing Information.<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

[10] Centers for Disease Control and Prevention. Vaccines & Immunizations. August 18, 2017. https:\/\/www.cdc.gov\/vaccines\/vac-gen\/immunity-types.htm<\/a>. Accessed December 2023.<\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table><\/div>\n

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England Journal of Medicine\uff0cNEJM\uff09\u4e0a\u3002[5,9]  \u57282\/3\u671fMEDLEY\u8bd5\u9a8c\u4e2d\uff0c\u5c3c\u585e\u97e6\u5355\u6297\u7684\u5b89\u5168\u6027\u4e0e\u5e15\u5229\u73e0\u5355\u6297\u76f8\u4f3c\uff0c\u540c\u65f6\u4e0eMELODY\u548c2b\u671f\u8bd5\u9a8c\u4e2d\u7814\u7a76\u7684\u5065\u5eb7\u8db3\u6708\u513f\u4e0e\u65e9\u4ea7\u513f\u7684\u5b89\u5168\u6027\u4fdd\u6301\u4e00\u81f4\u3002\u7814\u7a76\u4e2d\u5076\u89c1\u4e0d\u826f\u53cd\u5e94\uff0c\u62a5\u544a\u6700\u591a\u7684\u4e0d\u826f\u53cd\u5e94\u5305\u62ec\u7ed9\u836f\u540e14\u5929\u5185\u51fa\u73b0\u76ae\u75b9\uff08\u5927\u591a\u6570\u4e3a\u8f7b\u4e2d\u5ea6\uff09\uff1b\u4ee5\u53ca\u7ed9\u836f\u540e7\u5929\u5185\u51fa\u73b0\u975e\u4e25\u91cd\u7684\u6ce8\u5c04\u90e8\u4f4d\u53cd\u5e94\u3002[2,3,5,9]  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81.2)\uff0c\u6cbb\u7597\u7ec4\u89c2\u5bdf\u5230\u7684\u4e8b\u4ef6\u53d1\u751f\u7387\u4e3a2.6%\uff0c\u5b89\u6170\u5242\u7ec4\u4e3a9.5%\u30022016\u5e7411\u6708\u81f32017\u5e7412\u6708\u671f\u95f4\uff0c1453\u540d\u5a74\u513f\u5728RSV\u611f\u67d3\u5b63\u5f00\u59cb\u65f6\u88ab\u968f\u673a\u5206\u914d\u63a5\u53d7\u5c3c\u585e\u97e6\u5355\u6297\uff08n=969\uff09\u6216\u5b89\u6170\u5242\uff08n=484\uff09\u3002\u963f\u65af\u5229\u5eb7\u5728\u5357\u5317\u534a\u7403\u517123\u4e2a\u56fd\u5bb6\u7684164\u4e2a\u7814\u7a76\u4e2d\u5fc3\u5f00\u5c55\u4e86\u8fd9\u9879\u7814\u7a76\u3002\u7814\u7a76\u6570\u636e\u4e8e2020\u5e747\u6708\u53d1\u8868\u5728\u65b0\u82f1\u683c\u5170\u533b\u5b66\u6742\u5fd7\u4e0a\u3002[4]  \u5728\u9884\u5148\u8bbe\u5b9a\u7684\u6b21\u8981\u7ec8\u70b9\u4e0a\uff0c\u4e0e\u5b89\u6170\u5242\u76f8\u6bd4\uff0c\u5c3c\u585e\u97e6\u5355\u6297\u5c06\u9700\u8981\u4f4f\u9662\u7684RSV LRTI\u5c31\u8bca\u7387\u964d\u4f4e\u4e8678.4%\uff0895% CI 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