{"id":101594,"date":"2023-12-27T07:00:00","date_gmt":"2023-12-27T00:00:00","guid":{"rendered":"https:\/\/www.xinwengao.com\/cn\/pr\/20231227070000101594"},"modified":"2023-12-28T00:31:18","modified_gmt":"2023-12-27T16:31:18","slug":"%e4%bf%a1%e8%be%be%e7%94%9f%e7%89%a9%e4%b8%8e%e5%9c%a3%e5%9b%a0%e7%94%9f%e7%89%a9%e8%be%be%e6%88%90%e6%88%98%e7%95%a5%e5%90%88%e4%bd%9c%ef%bc%8c%e5%85%b1%e5%90%8c%e5%bc%80%e5%8f%91%e9%92%88%e5%af%b9","status":"publish","type":"post","link":"https:\/\/www.xinwengao.com\/cn\/pr\/20231227070000101594","title":{"rendered":"\u4fe1\u8fbe\u751f\u7269\u4e0e\u5723\u56e0\u751f\u7269\u8fbe\u6210\u6218\u7565\u5408\u4f5c\uff0c\u5171\u540c\u5f00\u53d1\u9488\u5bf9\u9ad8\u8840\u538b\u7684\u5c0f\u6838\u9178\uff08siRNA\uff09\u836f\u7269"},"content":{"rendered":"

\u7f8e\u56fd\u7f57\u514b\u7ef4\u5c14\u548c\u4e2d\u56fd\u82cf\u5dde<\/span>2023\u5e7412\u670827\u65e5<\/span> \/\u7f8e\u901a\u793e\/ — \u4fe1\u8fbe\u751f\u7269\u5236\u836f\u96c6\u56e2\uff08\u9999\u6e2f\u8054\u4ea4\u6240\u80a1\u7968\u4ee3\u7801\uff1a01801\uff09\uff0c\u4e00\u5bb6\u81f4\u529b\u4e8e\u7814\u53d1\u3001\u751f\u4ea7\u548c\u9500\u552e\u80bf\u7624\u3001\u81ea\u8eab\u514d\u75ab\u3001\u4ee3\u8c22\u3001\u773c\u79d1\u7b49\u91cd\u5927\u75be\u75c5\u9886\u57df\u521b\u65b0\u836f\u7269\u7684\u751f\u7269\u5236\u836f\u516c\u53f8\uff0c\u4e0eSanegene Bio USA<\/span> Inc.\uff08\u7b80\u79f0"\u5723\u56e0\u751f\u7269"\uff09\uff0c\u5ba3\u5e03\u8fbe\u6210\u6218\u7565\u5408\u4f5c\u534f\u8bae\uff0c\u5171\u540c\u5f00\u53d1\u9776\u5411\u8840\u7ba1\u7d27\u5f20\u7d20\u539f\uff08Angiotensinogen\uff0cAGT\uff09\u7684\u5c0f\u6838\u9178\uff08siRNA\uff09\u5019\u9009\u836f\u7269SGB-3908\u7528\u4e8e\u6cbb\u7597\u9ad8\u8840\u538b\uff0c\u540c\u65f6\u4fe1\u8fbe\u751f\u7269\u83b7\u5f97\u8be5\u836f\u7269\u672a\u6765\u5f00\u53d1\u3001\u751f\u4ea7\u548c\u5546\u4e1a\u5316\u7684\u72ec\u5bb6\u9009\u62e9\u6743\u3002<\/p>\n

\n

\"\"<\/a>
<\/span><\/p>\n<\/p><\/div>\n

SGB-3908\u76ee\u524d\u5904\u4e8eIND\u7533\u62a5\u51c6\u5907\u9636\u6bb5\uff0c\u662f\u5723\u56e0\u751f\u7269\u5177\u6709\u81ea\u4e3b\u77e5\u8bc6\u4ea7\u6743\u7684siRNA\u836f\u7269\uff0c\u57fa\u4e8e\u516c\u53f8\u4e13\u6709\u5c0f\u6838\u9178\u836f\u7269\u5f00\u53d1\u5e73\u53f0LEAD™\uff08Ligand and Enhancer Assisted Delivery\uff09\u5f00\u53d1\u3002\u6839\u636e\u5408\u4f5c\u534f\u8bae\uff0c\u53cc\u65b9\u5c06\u5171\u540c\u63a8\u8fdbSGB-3908\u7684\u5f00\u53d1\u81f3\u4e00\u5b9a\u9636\u6bb5\uff0c\u540c\u65f6\uff0c\u4fe1\u8fbe\u751f\u7269\u5c06\u83b7\u5f97\u72ec\u5bb6\u9009\u62e9\u6743\u5e76\u53ef\u5728\u672a\u6765\u652f\u4ed8\u884c\u6743\u8d39\u4ee5\u83b7\u5f97SGB-3908\u5728\u5168\u7403\u4e0d\u540c\u8303\u56f4\u5185\u7684\u72ec\u5bb6\u5f00\u53d1\u3001\u751f\u4ea7\u548c\u5546\u4e1a\u5316\u7684\u6743\u5229\u3002\u4fe1\u8fbe\u751f\u7269\u884c\u6743\u540e\uff0c\u5723\u56e0\u751f\u7269\u8fd8\u5c06\u6709\u6743\u83b7\u5f97\u540e\u7eed\u7814\u53d1\u91cc\u7a0b\u7891\u4ed8\u6b3e\u548c\u9500\u552e\u91cc\u7a0b\u7891\u4ed8\u6b3e\uff0c\u4ee5\u53ca\u5546\u4e1a\u5316\u540e\u57fa\u4e8e\u51c0\u9500\u552e\u989d\u7684\u5206\u7ea7\u63d0\u6210\u3002<\/p>\n

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\u4fe1\u8fbe\u751f\u7269\u5236\u836f\u96c6\u56e2\u603b\u88c1\u5218\u52c7\u519b\u535a\u58eb<\/b>\u8868\u793a\uff1a" \u6211\u4eec\u5f88\u9ad8\u5174\u4e0e\u5723\u56e0\u751f\u7269\u6218\u7565\u5408\u4f5c\u6cbb\u7597\u9ad8\u8840\u538b\u7684siRNA\u836f\u7269\u3002\u4fe1\u8fbe\u751f\u7269\u81ea\u51e0\u5e74\u524d\u6218\u7565\u6027\u5e03\u5c40\u4ee3\u8c22\u4e0e\u5fc3\u8840\u7ba1\uff08CVM\uff09\u9886\u57df\u65b0\u4e00\u4ee3\u521b\u65b0\u7597\u6cd5\uff0c\u9010\u6b65\u8fdb\u5165\u9ad8\u4ef7\u503c\u7ba1\u7ebf\u7684\u6536\u83b7\u671f\uff0c\u4fe1\u5fc5\u4e50®<\/sup>(PCSK9\u5355\u6297)\u5df2\u83b7\u6279\u4e0a\u5e02\u7528\u4e8e\u6cbb\u7597\u9ad8\u8102\u8840\u75c7\u3001\u739b\u4ed5\u5ea6\u80bd\uff08GLP-1R\/GCGR\uff09\u7528\u4e8e\u6cbb\u7597\u7cd6\u5c3f\u75c5\u548c\u80a5\u80d6\u5373\u5c06\u9012\u4ea4\u9996\u4e2aNDA\u3001IBI311\uff08IGF-1R\u5355\u6297\uff09\u6cbb\u7597\u7532\u72b6\u817a\u773c\u75c5\u8fdb\u5165III\u671f\u4e34\u5e8a\u3001IBI128\uff08XOI\u6291\u5236\u5242\uff09\u6cbb\u7597\u9ad8\u5c3f\u9178\u8840\u75c7\u6d77\u5916\u5df2\u5904\u4e8eIII\u671f\u4e34\u5e8a\u3002\u4e0e\u5723\u56e0\u751f\u7269\u7684\u5408\u4f5c\u5c06\u8fdb\u4e00\u6b65\u62d3\u5c55\u4fe1\u8fbe\u5728CVM\u9886\u57df\u7684\u6218\u7565\u5e03\u5c40\uff0c\u5e76\u5f62\u6210\u66f4\u5b8c\u5907\u7684\u4ea7\u54c1\u77e9\u9635\u548c\u957f\u671f\u7ade\u4e89\u4f18\u52bf\u3002SGB-3908\u5df2\u7ecf\u8fdb\u5165IND\u7533\u62a5\u51c6\u5907\u9636\u6bb5\uff0c\u6211\u4eec\u671f\u5f85\u4e0e\u5723\u56e0\u5408\u4f5c\u5f00\u5c55\u8be5\u836f\u7269\u7684\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u4e3a\u5e7f\u5927\u9ad8\u8840\u538b\u60a3\u8005\u5e26\u6765\u521b\u65b0\u6027\u7684\u6cbb\u7597\u65b9\u6848\u3002"<\/p>\n

\u5723\u56e0\u751f\u7269\u521b\u59cb\u4eba\u517c<\/b>CEO\u738b\u4e3a\u6c11\u535a\u58eb<\/b>\u8868\u793a\uff1a"SGB-3908\u91c7\u7528\u4e86\u516c\u53f8\u5177\u6709\u81ea\u4e3b\u77e5\u8bc6\u4ea7\u6743\u7684LEAD™\u5e73\u53f0\u6280\u672f\uff0c\u8be5\u5e73\u53f0\u901a\u8fc7\u5bf9\u9012\u9001\u914d\u4f53\u3001\u9012\u9001\u589e\u5f3a\u5242\u3001\u4f4d\u7f6e\u7279\u5f02\u4e14\u5e8f\u5217\u76f8\u5173\u7684\u5316\u5b66\u4fee\u9970\u7684\u6a21\u5757\u5316\u8bbe\u8ba1\uff0c\u53ef\u7cbe\u51c6\u9776\u5411\u6572\u4f4e\u81f4\u75c5\u57fa\u56e0\u7684mRNA\u548c\u86cb\u767d\u8868\u8fbe\u6c34\u5e73\uff0c\u5e76\u7ef4\u6301\u4f18\u5f02\u7684\u836f\u7269\u6d3b\u6027\u548c\u836f\u6548\u6301\u4e45\u6027\u3002\u5723\u56e0\u5f88\u9ad8\u5174\u6709\u673a\u4f1a\u548c\u4fe1\u8fbe\u751f\u7269\u5408\u4f5c\uff0c\u4fe1\u8fbe\u751f\u7269\u62e5\u6709\u6df1\u539a\u7684\u533b\u836f\u5f00\u53d1\u4e13\u4e1a\u77e5\u8bc6\u548c\u4e30\u5bcc\u7684\u836f\u7269\u4e34\u5e8a\u5f00\u53d1\u548c\u5546\u4e1a\u5316\u7ecf\u9a8c\uff0c\u4e0e\u5723\u56e0\u751f\u7269\u5148\u8fdb\u7684\u5c0f\u6838\u9178\u836f\u7269\u5f00\u53d1\u6280\u672f\u76f8\u7ed3\u5408\uff0c\u5c06\u52a9\u529b\u516c\u53f8\u5145\u5206\u91ca\u653eRNAi\u6280\u672f\u7684\u5e94\u7528\u6f5c\u529b\uff0c\u52a0\u901f\u63a8\u8fdb\u5728\u7814\u7ba1\u7ebf\u7684\u4e34\u5e8a\u5f00\u53d1\u548c\u5546\u4e1a\u5316\u8fdb\u7a0b\uff0c\u6ee1\u8db3\u9ad8\u8840\u538b\u5e02\u573a\u672a\u88ab\u6ee1\u8db3\u7684\u4e34\u5e8a\u9700\u6c42\u3002"<\/p>\n

AGT\u662f\u80be\u7d20-\u8840\u7ba1\u7d27\u5f20\u7d20-\u919b\u56fa\u916e\u7cfb\u7edf\uff08RAAS\uff09\u7684\u6700\u4e0a\u6e38\u524d\u4f53\uff0c\u8be5\u9776\u70b9\u5728\u8840\u538b\uff08BP\uff09\u8c03\u8282\u4e2d\u7684\u4f5c\u7528\u5df2\u5f97\u5230\u8bc1\u5b9e\uff0c\u6291\u5236AGT\u5177\u6709\u516c\u8ba4\u7684\u6297\u9ad8\u8840\u538b\u6548\u679c\u3002SGB-3908\u53ef\u6291\u5236 AGT \u5728\u809d\u810f\u4e2d\u7684\u5408\u6210\uff0c\u4ece\u800c\u53ef\u80fd\u5bfc\u81f4 AGT \u86cb\u767d\u7684\u6301\u4e45\u51cf\u5c11\uff0c\u8fdb\u4e00\u6b65\u5bfc\u81f4\u8840\u7ba1\u6536\u7f29\u7d20 (Ang) II \u7684\u51cf\u5c11\uff0c\u6700\u7ec8\u8d77\u5230\u8212\u5f20\u8840\u7ba1\u3001\u964d\u4f4e\u8840\u538b\u7684\u6548\u679c\u3002<\/p>\n

\n

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<\/span><\/p>\n<\/p><\/div>\n

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\u5173\u4e8e\u4fe1\u8fbe\u751f\u7269<\/b><\/p>\n

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\u516c\u53f8\u5df2\u4e0e\u793c\u6765\u3001\u7f57\u6c0f\u3001\u8d5b\u8bfa\u83f2\u3001Adimab\u3001Incyte\u548cMD Anderson \u764c\u75c7\u4e2d\u5fc3\u7b49\u56fd\u9645\u5408\u4f5c\u65b9\u8fbe\u621030\u9879\u6218\u7565\u5408\u4f5c\u3002\u4fe1\u8fbe\u751f\u7269\u5728\u4e0d\u65ad\u81ea\u7814\u521b\u65b0\u836f\u7269\u3001\u8c0b\u6c42\u81ea\u8eab\u53d1\u5c55\u7684\u540c\u65f6\uff0c\u79c9\u627f\u7ecf\u6d4e\u5efa\u8bbe\u4ee5\u4eba\u6c11\u4e3a\u4e2d\u5fc3\u7684\u53d1\u5c55\u601d\u60f3\u3002\u591a\u5e74\u6765\uff0c\u59cb\u7ec8\u5fc3\u6000\u79d1\u5b66\u5584\u5ff5\uff0c\u575a\u5b88"\u4ee5\u60a3\u8005\u4e3a\u4e2d\u5fc3"\uff0c\u5fc3\u7cfb\u60a3\u8005\u5e76\u5173\u6ce8\u60a3\u8005\u5bb6\u5ead\uff0c\u79ef\u6781\u5c65\u884c\u793e\u4f1a\u8d23\u4efb\u3002\u516c\u53f8\u9646\u7eed\u53d1\u8d77\u3001\u53c2\u4e0e\u4e86\u591a\u9879\u836f\u54c1\u516c\u76ca\u63f4\u52a9\u9879\u76ee\uff0c\u8ba9\u8d8a\u6765\u8d8a\u591a\u7684\u60a3\u8005\u80fd\u591f\u5f97\u76ca\u4e8e\u751f\u547d\u79d1\u5b66\u7684\u8fdb\u6b65\uff0c\u4e70\u5f97\u5230\u3001\u7528\u5f97\u8d77\u9ad8\u8d28\u91cf\u7684\u751f\u7269\u836f\u3002\u81f32023\u5e7410\u6708\uff0c\u4fe1\u8fbe\u751f\u7269\u60a3\u8005\u63f4\u52a9\u9879\u76ee\u5df2\u60e0\u53ca17\u4f59\u4e07\u666e\u901a\u60a3\u8005\uff0c\u836f\u7269\u6350\u8d60\u603b\u4ef7\u503c34\u4ebf\u5143\u4eba\u6c11\u5e01\u3002\u4fe1\u8fbe\u751f\u7269\u5e0c\u671b\u548c\u5927\u5bb6\u4e00\u8d77\u52aa\u529b\uff0c\u63d0\u9ad8\u4e2d\u56fd\u751f\u7269\u5236\u836f\u4ea7\u4e1a\u7684\u53d1\u5c55\u6c34\u5e73\uff0c\u4ee5\u6ee1\u8db3\u767e\u59d3\u7528\u836f\u53ef\u53ca\u6027\u548c\u4eba\u6c11\u5bf9\u751f\u547d\u5065\u5eb7\u7f8e\u597d\u613f\u671b\u7684\u8ffd\u6c42\u3002<\/p>\n

\u8be6\u60c5\u8bf7\u8bbf\u95ee\u516c\u53f8\u7f51\u7ad9\uff1awww.innoventbio.com<\/a>\u6216\u516c\u53f8\u9886\u82f1\u8d26\u53f7www.linkedin.com\/company\/innovent-biologics\/<\/a>\u3002<\/p>\n

\u5173\u4e8e\u5723\u56e0\u751f\u7269<\/b><\/p>\n

\u5723\u56e0\u751f\u7269\u6210\u7acb\u4e8e2021\u5e74\u521d\uff0c\u662f\u4e00\u5bb6\u81f4\u529b\u4e8e\u5f00\u53d1\u57fa\u4e8eRNA\u5e72\u6270\uff08RNAi\uff09\u6280\u672f\u7684\u65b0\u578b\u5c0f\u6838\u9178\u836f\u7269\u7684\u751f\u7269\u5236\u836f\u516c\u53f8\uff0c\u5728\u4e2d\u56fd\u3001\u7f8e\u56fd\u5747\u62e5\u6709\u7814\u53d1\u4e2d\u5fc3\u3002\u521b\u59cb\u56e2\u961f\u662f\u6838\u9178\u836f\u7269\u9886\u57df\u77e5\u540d\u7684\u4e13\u5bb6\u56e2\u961f\uff0c\u62e5\u6709\u591a\u5e74\u7684\u6838\u9178\u836f\u7269\u5f00\u53d1\u7ecf\u9a8c\u548c\u4e1a\u754c\u524d\u6cbf\u7684\u6280\u672f\u5b9e\u529b\u3002\u6210\u7acb\u4e24\u5e74\u591a\u6765\uff0c\u516c\u53f8\u5df2\u5efa\u7acb\u4e86\u5177\u6709\u81ea\u4e3b\u77e5\u8bc6\u4ea7\u6743\u7684\u5168\u7403\u9886\u5148\u7684\u6838\u9178\u836f\u7269\u5316\u5b66\u4fee\u9970\u548c\u809d\u5185\u809d\u5916\u9012\u9001\u6280\u672f\u5e73\u53f0\uff0c\u66f4\u52a0\u9ad8\u6548\u5730\u6572\u9664\u81f4\u75c5\u57fa\u56e0\u3002\u516c\u53f8\u5feb\u901f\u5e03\u5c40\u4e86\u7cfb\u5217\u5c0f\u6838\u9178\u4ea7\u54c1\u7684\u7814\u7a76\u5f00\u53d1\uff0c\u6db5\u76d6\u5fc3\u8111\u8840\u7ba1\u53ca\u4ee3\u8c22\u75be\u75c5\u3001\u514d\u75ab\u7c7b\u75be\u75c5\u3001\u795e\u7ecf\u7cfb\u7edf\u75be\u75c5\u7b49\u9886\u57df\uff0c\u5723\u56e0\u751f\u7269\u81f4\u529b\u4e8e\u79d1\u5b66\u521b\u65b0\uff0c\u521b\u9020\u51fa\u65b0\u578bRNAi\u836f\u7269\uff0c\u89e3\u51b3\u5168\u7403\u672a\u6ee1\u8db3\u7684\u533b\u7597\u9700\u6c42\uff0c\u9020\u798f\u60a3\u8005\u53ca\u5176\u5bb6\u5ead\u3002\u4e86\u89e3\u66f4\u591a\uff0c\u8bf7\u8bbf\u95ee\u5723\u56e0\u5b98\u7f51 www.sanegenebio.com<\/a> <\/p>\n

\u4fe1\u8fbe\u751f\u7269\u524d\u77bb\u6027\u58f0\u660e<\/b><\/p>\n

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\u8fd9\u4e9b\u524d\u77bb\u6027\u8868\u8ff0\u662f\u57fa\u4e8e\u672c\u516c\u53f8\u7ba1\u7406\u5c42\u5728\u505a\u51fa\u8868\u8ff0\u65f6\u5bf9\u672a\u6765\u4e8b\u52a1\u7684\u73b0\u6709\u770b\u6cd5\u3001\u5047\u8bbe\u3001\u671f\u671b\u3001\u4f30\u8ba1\u3001\u9884\u6d4b\u548c\u7406\u89e3\u3002\u8fd9\u4e9b\u8868\u8ff0\u5e76\u975e\u5bf9\u672a\u6765\u53d1\u5c55\u7684\u4fdd\u8bc1\uff0c\u4f1a\u53d7\u5230\u98ce\u9669\u3001\u4e0d\u786e\u6027\u53ca\u5176\u4ed6\u56e0\u7d20\u7684\u5f71\u54cd\uff0c\u6709\u4e9b\u662f\u8d85\u51fa\u672c\u516c\u53f8\u7684\u63a7\u5236\u8303\u56f4\uff0c\u96be\u4ee5\u9884\u8ba1\u3002\u56e0\u6b64\uff0c\u53d7\u6211\u4eec\u7684\u4e1a\u52a1\u3001\u7ade\u4e89\u73af\u5883\u3001\u653f\u6cbb\u3001\u7ecf\u6d4e\u3001\u6cd5\u5f8b\u548c\u793e\u4f1a\u60c5\u51b5\u7684\u672a\u6765\u53d8\u5316\u53ca\u53d1\u5c55\u7684\u5f71\u54cd\uff0c\u5b9e\u9645\u7ed3\u679c\u53ef\u80fd\u4f1a\u4e0e\u524d\u77bb\u6027\u8868\u8ff0\u6240\u542b\u8d44\u6599\u6709\u8f83\u5927\u5dee\u522b\u3002<\/p>\n

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\n\n\n\n\n
\n

\u53c2\u8003\u6587\u732e<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

[i]<\/sup> Global report on hypertension: the race against a silent killer, WHO 2023, https:\/\/www.who.int\/publications\/i\/item\/9789240081062<\/a> <\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table><\/div>\n

<\/div>\n","protected":false},"excerpt":{"rendered":"

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