\u6ee1\u8db3\u79fb\u690d\u540e\u5de8\u7ec6\u80de\u75c5\u6bd2\u611f\u67d3\u6cbb\u7597\u4e34\u5e8a\u6025\u9700<\/b><\/p>\n
\u4e0a\u6d77<\/span>2023\u5e7412\u670821\u65e5<\/span> \/\u7f8e\u901a\u793e\/ — \u6b66\u7530\u4e2d\u56fd\u4eca\u65e5\u5ba3\u5e03\uff0c\u65d7\u4e0b\u6297\u75c5\u6bd2\u611f\u67d3\u9886\u57df\u521b\u65b0\u836f\u7269\u9a6c\u7acb\u5df4\u97e6\u7247\uff08\u6291\u6cf0\u4e4b®<\/sup>\uff09\u6b63\u5f0f\u83b7\u5f97\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08NMPA\uff09\u6279\u51c6\uff0c\u9002\u7528\u4e8e\u6cbb\u7597\u9020\u8840\u5e72\u7ec6\u80de\u79fb\u690d\u6216\u5b9e\u4f53\u5668\u5b98\u79fb\u690d\u540e\u5de8\u7ec6\u80de\u75c5\u6bd2(CMV)\u611f\u67d3\u548c\/\u6216\u75be\u75c5\uff0c\u4e14\u5bf9\u4e00\u79cd\u6216\u591a\u79cd\u65e2\u5f80\u6cbb\u7597\uff08\u66f4\u6614\u6d1b\u97e6\u3001\u7f2c\u66f4\u6614\u6d1b\u97e6\u3001\u897f\u591a\u798f\u97e6\u6216\u81a6\u7532\u9178\u94a0\uff09\u96be\u6cbb\uff08\u4f34\u6216\u4e0d\u4f34\u57fa\u56e0\u578b\u8010\u836f\uff09\u7684\u6210\u4eba\u60a3\u8005\u3002\u9a6c\u7acb\u5df4\u97e6\u7247\u662f\u5168\u7403\u9996\u4e2a\u4e14\u76ee\u524d\u552f\u4e00\u4e00\u4e2a\u9776\u5411\u5e76\u6291\u5236UL97\u86cb\u767d\u6fc0\u9176\u53ca\u5176\u5929\u7136\u5e95\u7269\u7684\u6297\u75c5\u6bd2\u5236\u5242[1]<\/sup>\uff0c\u5176\u83b7\u6279\u5c06\u4e3a\u4e2d\u56fd\u96be\u6cbb\u6027CMV\u611f\u67d3\u6216\u75be\u75c5\u7684\u79fb\u690d\u53d7\u8005\u63d0\u4f9b\u4e00\u79cd\u5168\u65b0\u7684\u53e3\u670d\u6cbb\u7597\u9009\u62e9\u30022021\u5e741\u6708\uff0c\u9a6c\u7acb\u5df4\u97e6\u7247\u88ab\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u836f\u54c1\u5ba1\u8bc4\u4e2d\u5fc3\u6b63\u5f0f\u8ba4\u5b9a\u4e3a"\u7a81\u7834\u6027\u6cbb\u7597\u836f\u7269\u54c1\u79cd"\u3002<\/p>\n \u6b66\u7530\u5236\u836f\u5168\u7403\u9ad8\u7ea7\u526f\u603b\u88c1\u3001\u6b66\u7530\u4e2d\u56fd\u603b\u88c1\u5355\u56fd\u6d2a\u5148\u751f<\/b>\u8868\u793a\uff1a"\u611f\u8c22\u653f\u5e9c\u76f8\u5173\u90e8\u95e8\u8fd1\u5e74\u6765\u9f13\u52b1\u521b\u65b0\u836f\u7269\u7684\u4e00\u7cfb\u5217\u5229\u597d\u653f\u7b56\uff0c\u4f7f\u9a6c\u7acb\u5df4\u97e6\u7247\u80fd\u591f\u901a\u8fc7\u4f18\u5148\u5ba1\u8bc4\u5ba1\u6279\u5728\u4e2d\u56fd\u5feb\u901f\u83b7\u6279\u3002\u8fd9\u662f\u4e00\u4e2a\u91cd\u8981\u7684\u91cc\u7a0b\u7891\uff0c\u6b64\u6b21\u83b7\u6279\u5c06\u5f7b\u5e95\u6539\u53d8\u79fb\u690d\u60a3\u8005\u53d1\u751fCMV\u611f\u67d3\u540e\u7684\u8bca\u7597\u56f0\u5883\uff0c\u4e3a\u4e2d\u56fd\u60a3\u8005\u5e26\u6765\u65b0\u7684\u751f\u5b58\u5e0c\u671b\u3002\u672a\u6765\uff0c\u6b66\u7530\u5c06\u7ee7\u7eed\u52a0\u901f\u5f15\u5165\u66f4\u591a\u5168\u7403\u521b\u65b0\u4ea7\u54c1\uff0c\u8ba9\u4e2d\u56fd\u60a3\u8005\u5c3d\u65e9\u4ece\u9ad8\u5ea6\u521b\u65b0\u7684\u836f\u7269\u548c\u53d8\u9769\u6027\u7684\u7597\u6cd5\u4e2d\u83b7\u76ca\u3002"<\/p>\n CMV\u662f\u4e00\u79cd\u5e38\u89c1\u7684\u03b2-\u75b1\u75b9\u75c5\u6bd2\uff0c\u53ef\u572840%-100%\u7684\u6210\u4eba\u4eba\u7fa4\u4e2d\u53d1\u73b0\u65e2\u5f80\u611f\u67d3\u7684\u8840\u6e05\u5b66\u8bc1\u636e[2]<\/sup>\u3002\u5728\u5168\u7403\u6bcf\u5e7420\u4e07\u4f8b\u6210\u4eba\u79fb\u690d\u75c5\u4f8b\u4e2d\uff0cCMV\u662f\u79fb\u690d\u53d7\u8005\u6700\u5e38\u89c1\u7684\u75c5\u6bd2\u611f\u67d3\u4e4b\u4e00\uff0c\u5728\u5b9e\u4f53\u5668\u5b98\u79fb\u690d\u53d7\u8005\u4e2d\u7684\u53d1\u751f\u7387\u4e3a16-56%\uff0c\u5728\u9020\u8840\u5e72\u7ec6\u80de\u79fb\u690d\u53d7\u8005\u4e2d\u7684\u53d1\u751f\u7387\u4e3a30-70%[3],[4],[5]<\/sup>\u3002\u5bf9\u4e8e\u514d\u75ab\u529f\u80fd\u4f4e\u4e0b\u7684\u60a3\u8005\uff0cCMV\u611f\u67d3\u53ef\u80fd\u4f1a\u5371\u53ca\u751f\u547d\u3002\u5728\u7ecf\u5386\u9020\u8840\u5e72\u7ec6\u80de\u79fb\u690d\u6216\u5b9e\u4f53\u5668\u5b98\u79fb\u690d\u540e\uff0c\u60a3\u8005\u4e0d\u53ef\u907f\u514d\u4f1a\u56e0\u5e94\u7528\u514d\u75ab\u6291\u5236\u5242\u800c\u5bfc\u81f4\u514d\u75ab\u7cfb\u7edf\u53d7\u635f\u3002\u6b64\u65f6, \u5982\u679c\u53d1\u751f\u4e86CMV\u611f\u67d3\u53ef\u80fd\u4f1a\u5bfc\u81f4\u79fb\u690d\u5931\u8d25\u7b49\u4e25\u91cd\u540e\u679c\uff0c\u5728\u6781\u7aef\u60c5\u51b5\u4e0b\u751a\u81f3\u4f1a\u5bfc\u81f4\u60a3\u8005\u6b7b\u4ea1\uff0c\u56e0\u6b64CMV\u4e5f\u88ab\u79f0\u4e3a\u2018\u79fb\u690d\u7684\u5de8\u9b54’\u3002<\/p>\n \u76ee\u524d\uff0c\u6cbb\u7597\u79fb\u690d\u540eCMV\u611f\u67d3\u7684\u73b0\u6709\u6cbb\u7597\u65b9\u6848\u53ef\u80fd\u4f1a\u5e26\u6765\u4e25\u91cd\u7684\u526f\u4f5c\u7528\uff0c\u4e5f\u53ef\u80fd\u65e0\u6cd5\u5145\u5206\u6291\u5236\u75c5\u6bd2\u590d\u5236\u3002\u6b64\u5916\uff0c\u7531\u4e8e\u7ed9\u836f\u65b9\u5f0f\u7684\u539f\u56e0\uff0c\u73b0\u6709\u6cbb\u7597\u65b9\u6848\u53ef\u80fd\u4f1a\u8981\u6c42\u60a3\u8005\u4f4f\u9662\u6216\u8005\u5ef6\u957f\u60a3\u8005\u7684\u4f4f\u9662\u65f6\u95f4\uff0c\u60a3\u8005\u75be\u75c5\u8d1f\u62c5\u5927\u5927\u589e\u52a0\uff0c\u56e0\u6b64\u4e34\u5e8a\u4e0a\u8feb\u5207\u9700\u8981\u521b\u65b0\u7597\u6548\u597d\u4e14\u5b89\u5168\u6027\u9ad8\u7684\u6cbb\u7597\u836f\u7269\u3002<\/p>\n \u9a6c\u7acb\u5df4\u97e6\u7247\u662f\u4e00\u79cd\u53e3\u670d\u6297CMV\u521b\u65b0\u836f\uff0c\u4ee5CMV UL97\u86cb\u767d\u6fc0\u9176\u4e3a\u9776\u70b9\uff0c\u4e09\u91cd\u6291\u5236\u75c5\u6bd2DNA\u7684\u590d\u5236\u3001\u8863\u58f3\u5316\u548c\u6838\u9003\u9038, \u4ece\u800c\u6e05\u9664CMV\u8840\u75c7\u5e76\u63a7\u5236\u76f8\u5173\u75c7\u72b6\u3002\u5728\u4e00\u9879\u591a\u4e2d\u5fc3\u3001\u968f\u673a\u3001\u5f00\u653e\u6807\u7b7e\u3001\u9633\u6027\u836f\u7269\u5bf9\u7167\u7684\u2162\u671f\u4f18\u6548\u6027\u7814\u7a76\uff08TAK-620-303\uff09\u4e2d\uff0c\u7ed3\u679c\u663e\u793a\u670955.7% (n=131\/235) \u63a5\u53d7\u9a6c\u7acb\u5df4\u97e6\u7247\u6cbb\u7597\u7684\u60a3\u8005\u5728\u7b2c8 \u5468\u8fbe\u5230\u4e86CMV\u8840\u75c7\u7684\u6e05\u9664\uff08\u5373\u6839\u636e\u4e2d\u5fc3\u5b9e\u9a8c\u5ba4\u7ed3\u679c\uff0c\u95f4\u9694\u81f3\u5c115\u5929\u76842\u4e2a\u8fde\u7eed\u57fa\u7ebf\u540e\u6837\u672c\u7684\u8840\u6d46CMV DNA\u6d53\u5ea6\u4f4e\u4e8e\u5b9a\u91cf\u4e0b\u9650\uff09\uff0c\u800c\u63a5\u53d7\u5e38\u89c4\u6cbb\u7597\u7684\u60a3\u8005\u4e3a 23.9%(n=28\/117)\uff08\u6821\u6b63\u540e\u7684\u5dee\u5f02 [95% \u7f6e\u4fe1\u533a\u95f4(CI)]\uff1a32.8% [22.80\u201342.74]\uff1bP <0.001\uff09[6]<\/sup>\u3002\u540c\u65f6\uff0c\u9a6c\u7acb\u5df4\u97e6\u7247\u4e0e\u5e38\u89c4\u6297\u75c5\u6bd2\u6cbb\u7597\u76f8\u6bd4\uff0c\u6cbb\u7597\u76f8\u5173\u6bd2\u6027\u66f4\u4f4e\u3002\u7814\u7a76\u7ed3\u679c\u663e\u793a\uff0c\u670925%(n=14\/56)\u63a5\u53d7\u7f2c\u66f4\u6614\u6d1b\u97e6\/\u66f4\u6614\u6d1b\u97e6\u6cbb\u7597\u7684\u60a3\u8005\u53d1\u751f\u6cbb\u7597\u76f8\u5173\u7684\u4e2d\u6027\u7c92\u7ec6\u80de\u51cf\u5c11\uff0c\u800c\u63a5\u53d7\u9a6c\u7acb\u5df4\u97e6\u6cbb\u7597\u7684\u60a3\u8005\u4ec5\u4e3a1.7% (n=4\/234)\u3002\u540c\u65f6\uff0c\u670919.1%(n=9\/47)\u63a5\u53d7\u81a6\u7532\u9178\u94a0\u6cbb\u7597\u7684\u60a3\u8005\u53d1\u751f\u4e86\u6025\u6027\u80be\u635f\u4f24\uff0c\u800c\u63a5\u53d7\u9a6c\u7acb\u5df4\u97e6\u6cbb\u7597\u7684\u60a3\u8005\u4ec5\u4e3a1.7% (n=4\/234)\u3002<\/p>\n \u6b66\u7530\u7814\u53d1\u5168\u7403\u526f\u603b\u88c1\uff0c\u4e9a\u592a\u7814\u53d1\u8d1f\u8d23\u4eba\u738b\u7498\u535a\u58eb<\/b>\u8868\u793a\uff1a"\u79c9\u6301\u60a3\u8005\u4e3a\u5148\u7684\u7406\u5ff5\uff0c\u6211\u4eec\u975e\u5e38\u6b23\u559c\u5730\u770b\u5230\u9a6c\u7acb\u5df4\u97e6\u7247\u5728\u4e2d\u56fd\u6210\u529f\u83b7\u6279\u3002\u9a6c\u7acb\u5df4\u97e6\u7247\u5177\u6709\u65b0\u578b\u6297\u5de8\u7ec6\u80de\u75c5\u6bd2\uff08CMV\uff09\u4f5c\u7528\u673a\u5236\uff0c\u5c06\u4ece\u6839\u672c\u4e0a\u6539\u53d8\u79fb\u690d\u540e\u96be\u6cbb\u6027\uff08\u4f34\u6216\u4e0d\u4f34\u8010\u836f\u6027\uff09\u5de8\u7ec6\u80de\u75c5\u6bd2\u611f\u67d3\u6216\u75be\u75c5\u7684\u6cbb\u7597\u65b9\u5f0f\uff0c\u4e3a\u4e2d\u56fd\u60a3\u8005\u5e26\u6765\u65b0\u7684\u7a81\u7834\u6027\u6cbb\u7597\u9009\u62e9\u3002\u672a\u6765\uff0c\u6b66\u7530\u5c06\u7ee7\u7eed\u53d1\u6325\u5176\u521b\u65b0\u7814\u53d1\u5b9e\u529b\uff0c\u4ee5\u79d1\u5b66\u4e3a\u57fa\u7840\uff0c\u901a\u8fc7\u5c06\u4e2d\u56fd\u60a3\u8005\u7684\u672a\u5c3d\u9700\u6c42\u66f4\u65e9\u7684\u7eb3\u5165\u5168\u7403\u65e9\u671f\u7814\u53d1\u7b56\u7565\u4e2d\uff0c\u8fdb\u4e00\u6b65\u52a0\u901f\u5168\u7403\u521b\u65b0\u836f\u7269\u7684\u83b7\u6279\uff0c\u60e0\u53ca\u66f4\u591a\u4e2d\u56fd\u60a3\u8005\u3002"<\/p>\n \u9a6c\u7acb\u5df4\u97e6\u7247\u76ee\u524d\u5df2\u5728\u7f8e\u56fd\u3001\u6b27\u6d32\u3001\u97e9\u56fd\u548c\u6fb3\u5927\u5229\u4e9a\u83b7\u5f97\u5b64\u513f\u836f\u8d44\u683c\u8ba4\u5b9a\uff0c\u5206\u522b\u4e8e2021\u5e7411\u6708\u83b7\u5f97\u7f8e\u56fd\u98df\u54c1\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08FDA\uff09\u6279\u51c6\u4e0a\u5e02\uff0c\u4e8e2022\u5e7411\u6708\uff0c\u83b7\u5f97\u6b27\u76df\u59d4\u5458\u4f1a\uff08EC\uff09\u6279\u51c6\u4e0a\u5e02\u3002<\/p>\n \u5ba1\u6279\u7f16\u53f7\uff1aC-ANPROM\/CN\/MARI\/0022 \u58f0\u660e<\/b><\/p>\n \u5173\u4e8e\u6b66\u7530\u5236\u836f<\/b><\/p>\n \u6b66\u7530\u5236\u836f\uff08\u4e1c\u4eac\u8bc1\u5238\u4ea4\u6613\u6240\u80a1\u7968\u4ee3\u7801\uff1a4502<\/a>\uff09\uff08\u7ebd\u7ea6\u8bc1\u5238\u4ea4\u6613\u6240\u80a1\u7968\u4ee3\u7801\uff1aTAK\uff09\u662f\u4e00\u5bb6\u603b\u90e8\u4f4d\u4e8e\u65e5\u672c\u3001\u4ee5\u4ef7\u503c\u89c2\u4e3a\u57fa\u7840\u3001\u4ee5\u7814\u53d1\u4e3a\u9a71\u52a8\u7684\u5168\u7403\u751f\u7269\u5236\u836f\u516c\u53f8\u3002\u6b66\u7530\u81f4\u529b\u4e8e\u5c06\u79d1\u5b66\u7814\u53d1\u6210\u679c\u8f6c\u5316\u4e3a\u9ad8\u5ea6\u521b\u65b0\u836f\u54c1\uff0c\u4e3a\u60a3\u8005\u7684\u5065\u5eb7\u751f\u6d3b\u548c\u7f8e\u597d\u672a\u6765\u4fdd\u9a7e\u62a4\u822a\u3002\u6b66\u7530\u4e13\u6ce8\u4e8e\u56db\u5927\u6cbb\u7597\u9886\u57df\u7684\u836f\u7269\u7814\u53d1\uff1a\u80bf\u7624\u3001\u6d88\u5316\u3001\u795e\u7ecf\u79d1\u5b66\u53ca\u7f55\u89c1\u75c5\u9886\u57df\uff0c\u5e76\u9488\u5bf9\u8840\u6db2\u5236\u54c1\u53ca\u75ab\u82d7\u9886\u57df\u8fdb\u884c\u4e13\u9879\u7814\u53d1\u6295\u5165\u3002\u6211\u4eec\u59cb\u7ec8\u4e13\u6ce8\u4e8e\u9ad8\u5ea6\u521b\u65b0\u836f\u7269\u7684\u7814\u53d1\uff0c\u901a\u8fc7\u5f00\u62d3\u5168\u65b0\u6cbb\u7597\u65b9\u6848\u3001\u589e\u5f3a\u5408\u4f5c\u7814\u53d1\u5f15\u64ce\u5b9e\u529b\uff0c\u6253\u9020\u4e00\u6761\u7a33\u5065\u4e14\u5f62\u5f0f\u591a\u6837\u7684\u4ea7\u54c1\u7ba1\u7ebf\uff0c\u52a9\u529b\u6539\u5584\u4eba\u4eec\u7684\u751f\u6d3b\u3002\u6211\u4eec\u7684\u5458\u5de5\u904d\u5e03\u4e8e\u5927\u7ea680\u4e2a\u56fd\u5bb6\u548c\u5730\u533a\uff0c\u4e0e\u5f53\u5730\u533b\u7597\u5065\u5eb7\u5408\u4f5c\u4f19\u4f34\u643a\u624b\uff0c\u4e3a\u5168\u7403\u60a3\u8005\u5e26\u6765\u5065\u5eb7\u798f\u97f3\u3002<\/p>\n \u6b66\u7530\u4e8e1994\u5e74\u8fdb\u5165\u4e2d\u56fd\uff0c\u6b66\u7530\u4e2d\u56fd\u603b\u90e8\u4f4d\u4e8e\u4e0a\u6d77\uff0c\u5728\u4e2d\u56fd\u5927\u9646\u7684\u4e3b\u8981\u4e1a\u52a1\u4e2d\u5fc3\u4f4d\u4e8e\u5317\u4eac\u3001\u4e0a\u6d77\u3001\u5929\u6d25\u3001\u5e7f\u5dde\u3001\u9999\u6e2f\u7279\u522b\u884c\u653f\u533a\u7b49\u57ce\u5e02\u548c\u5730\u533a\uff0c\u5e76\u5728\u5168\u56fd\u5404\u4e3b\u8981\u57ce\u5e02\u8bbe\u6709\u529e\u4e8b\u5904\uff0c\u76ee\u524d\u5728\u4e2d\u56fd\u62e5\u6709\u8d85\u8fc72000\u540d\u5458\u5de5\u3002\u968f\u7740\u4e2d\u56fd\u7ecf\u6d4e\u7684\u53d1\u5c55\u548c\u5bf9\u533b\u7597\u4fdd\u5065\u9700\u6c42\u7684\u4e0d\u65ad\u589e\u957f\uff0c\u4e2d\u56fd\u5df2\u7ecf\u6210\u4e3a\u6b66\u7530\u5168\u7403\u6700\u91cd\u8981\u7684\u65b0\u5174\u5e02\u573a\u4e4b\u4e00\u3002<\/p>\n \u66f4\u591a\u4fe1\u606f\uff0c\u656c\u8bf7\u8bbf\u95eehttps:\/\/www.takeda.com<\/a><\/p>\n \u524d\u77bb\u6027\u58f0\u660e<\/b><\/p>\n \u672c\u7a3f\u4ef6\u53ca\u4e0e\u4e4b\u76f8\u5173\u7684\u6240\u5206\u53d1\u7684\u4efb\u4f55\u8d44\u6599\u53ef\u80fd\u542b\u6709\u4e0e\u6b66\u7530\u672a\u6765\u4e1a\u52a1\u3001\u672a\u6765\u72b6\u51b5\u548c\u8fd0\u8425\u4e1a\u7ee9\u6709\u5173\u7684\u524d\u77bb\u6027\u9648\u8ff0\u3001\u770b\u6cd5\u6216\u610f\u89c1\uff0c\u5305\u62ec\u6b66\u7530\u7684\u9884\u4f30\u3001\u9884\u6d4b\u3001\u76ee\u6807\u548c\u8ba1\u5212\u3002\u524d\u77bb\u6027\u9648\u8ff0\u5e38\u5e38\u5305\u542b\u4f46\u4e0d\u9650\u4e8e\u4e0b\u5217\u63aa\u8f9e\uff0c\u4f8b\u5982"\u76ee\u6807"\u3001"\u8ba1\u5212"\u3001"\u8ba4\u4e3a"\u3001"\u5e0c\u671b"\u3001"\u7ee7\u7eed"\u3001"\u9884\u8ba1"\u3001"\u65e8\u5728"\u3001"\u6253\u7b97"\u3001"\u786e\u4fdd"\u3001"\u5c06"\u3001"\u53ef\u80fd"\u3001"\u5e94"\u3001"\u4f1a"\u3001"\u6216\u8bb8"\u3001"\u9884\u671f"\u3001"\u4f30\u8ba1"\u3001"\u9884\u6d4b"\u6216\u7c7b\u4f3c\u8868\u8ff0\u6216\u5176\u5426\u5b9a\u5f62\u5f0f\u3002<\/p>\n \u672c\u6587\u4e2d\u7684\u524d\u77bb\u6027\u9648\u8ff0\u4ec5\u57fa\u4e8e\u6b66\u7530\u622a\u81f3\u53d1\u5e03\u65e5\u671f\u7684\u4f30\u8ba1\u548c\u5047\u8bbe\u3002\u6b64\u7c7b\u524d\u77bb\u6027\u58f0\u660e\u5e76\u975e\u662f\u6b66\u7530\u6216\u5176\u7ba1\u7406\u5c42\u5bf9\u672a\u6765\u4e1a\u7ee9\u6240\u505a\u7684\u4efb\u4f55\u4fdd\u8bc1\uff0c\u5e76\u6d89\u53ca\u5df2\u77e5\u548c\u672a\u77e5\u7684\u98ce\u9669\u3001\u4e0d\u786e\u5b9a\u6027\u548c\u5176\u4ed6\u56e0\u7d20\uff0c\u5305\u62ec\u4f46\u4e0d\u9650\u4e8e\uff1a\u6b66\u7530\u5168\u7403\u4e1a\u52a1\u6240\u9762\u4e34\u7684\u7ecf\u6d4e\u5f62\u52bf\uff0c\u5305\u62ec\u65e5\u672c\u548c\u7f8e\u56fd\u7684\u5b8f\u89c2\u7ecf\u6d4e\u73af\u5883\uff1b\u7ade\u4e89\u538b\u529b\u548c\u53d1\u5c55\u60c5\u51b5\uff1b\u9002\u7528\u6cd5\u5f8b\u6cd5\u89c4\u7684\u53d8\u52a8\uff1b\u4ea7\u54c1\u5f00\u53d1\u9879\u76ee\u7684\u6210\u529f\u6216\u5931\u8d25\uff1b\u76d1\u7ba1\u5f53\u5c40\u7684\u51b3\u7b56\u6216\u505a\u51fa\u51b3\u7b56\u7684\u65f6\u673a\uff1b\u5229\u7387\u548c\u6c47\u7387\u6ce2\u52a8\uff1b\u6709\u5173\u5df2\u552e\u4ea7\u54c1\u6216\u5019\u9009\u4ea7\u54c1\u5b89\u5168\u6216\u529f\u6548\u7684\u7d22\u8d54\u6216\u7591\u95ee\uff1b\u5df2\u6536\u8d2d\u516c\u53f8\u7684\u5408\u5e76\u540e\u6574\u5408\u52aa\u529b\u7684\u65f6\u673a\u548c\u5f71\u54cd\uff1b\u4ee5\u53ca\u80fd\u5426\u5265\u79bb\u5bf9\u6b66\u7530\u8fd0\u8425\u975e\u6838\u5fc3\u7684\u8d44\u4ea7\u548c\u4efb\u4f55\u6b64\u7c7b\u5265\u79bb\u7684\u65f6\u673a\uff0c\u6240\u6709\u8fd9\u4e9b\u90fd\u53ef\u80fd\u4f1a\u5bfc\u81f4\u6b66\u7530\u7684\u5b9e\u9645\u4e1a\u7ee9\u3001\u8868\u73b0\u3001\u6210\u5c31\u6216\u8d22\u52a1\u72b6\u51b5\u4e0e\u6b64\u7c7b\u524d\u77bb\u6027\u9648\u8ff0\u6240\u63cf\u8ff0\u6216\u6697\u6307\u7684\u4efb\u4f55\u672a\u6765\u4e1a\u7ee9\u3001\u8868\u73b0\u3001\u6210\u5c31\u6216\u8d22\u52a1\u72b6\u51b5\u53d1\u751f\u91cd\u5927\u504f\u5dee\u3002<\/p>\n \u5173\u4e8e\u4ee5\u4e0a\u53ca\u53ef\u80fd\u5f71\u54cd\u6b66\u7530\u7ed3\u679c\u3001\u4e1a\u7ee9\u3001\u6210\u5c31\u6216\u8d22\u52a1\u72b6\u51b5\u7684\u5176\u4ed6\u56e0\u7d20\u7684\u66f4\u591a\u4fe1\u606f\uff0c\u8bf7\u53c2\u9605\u6b66\u7530\u5411\u7f8e\u56fd\u8bc1\u5238\u4ea4\u6613\u59d4\u5458\u4f1a\u63d0\u4ea4\u7684Form 20-F\u6700\u65b0\u5e74\u62a5"\u7b2c3\u9879. \u5173\u952e\u4fe1\u606f\u2014D. \u98ce\u9669\u56e0\u7d20"\u548c\u5176\u4ed6\u62a5\u544a\uff0c\u5177\u4f53\u8bf7\u67e5\u9605\u6b66\u7530\u7f51\u7ad9https:\/\/www.takeda.com\/investors\/reports\/sec-filings\/\u6216www.sec.gov\u3002\u6b66\u7530\u7684\u672a\u6765\u7ed3\u679c\u3001\u4e1a\u7ee9\u6210\u5c31\u6216\u8d22\u52a1\u5730\u4f4d\u53ef\u80fd\u4e0e\u524d\u77bb\u6027\u9648\u8ff0\u6240\u8a00\u4f20\u6216\u610f\u4f1a\u7684\u5185\u5bb9\u6709\u5b9e\u8d28\u6027\u5dee\u8ddd\u3002\u6536\u5230\u8fd9\u4e00\u65b0\u95fb\u7a3f\u7684\u4e2a\u4eba\u4e0d\u5e94\u5bf9\u4efb\u4f55\u524d\u77bb\u6027\u9648\u8ff0\u5bc4\u4e88\u4e0d\u9002\u5207\u7684\u4f9d\u8d56\u3002\u6b66\u7530\u6ca1\u6709\u4e49\u52a1\u66f4\u65b0\u672c\u65b0\u95fb\u7a3f\u4e2d\u7684\u4efb\u4f55\u524d\u77bb\u6027\u9648\u8ff0\u6216\u516c\u53f8\u53ef\u80fd\u53d1\u5e03\u7684\u4efb\u4f55\u5176\u4ed6\u524d\u77bb\u6027\u9648\u8ff0\uff0c\u9664\u975e\u662f\u6cd5\u5f8b\u6216\u8bc1\u5238\u4ea4\u6613\u89c4\u5219\u6240\u8981\u6c42\u3002\u5386\u53f2\u4e1a\u7ee9\u5e76\u4e0d\u80fd\u4ee3\u8868\u672a\u6765\u4e1a\u7ee9\uff0c\u800c\u4e14\u672c\u65b0\u95fb\u7a3f\u4e2d\u7684\u6b66\u7530\u4e1a\u7ee9\u5e76\u4e0d\u80fd\u6307\u4ee3\uff0c\u4e5f\u5e76\u975e\u662f\u6b66\u7530\u672a\u6765\u4e1a\u7ee9\u7684\u9884\u4f30\u3001\u9884\u6d4b\u6216\u63a8\u6d4b\u3002<\/p>\n [1] Avram S, et al. Novel drug targets in 2021. Nat. Rev. Drug Discov. 2022;21(5):328-328.\uff08\u622a\u6b62\u81f32023\u5e7412\u670821\u65e5\uff09<\/span><\/p>\n<\/td>\n<\/tr>\n [2] Krech U. Complement-fixing antibodies against cytomegalovirus in different parts of the world. Bull WHO 1973;49:103\/6.<\/span><\/p>\n<\/td>\n<\/tr>\n [3] Azevedo L, Pierrotti L, Abdala E, et al. Cytomegalovirus infection in transplant recipients. Clinics. 2015;70(7):515-523. doi:10.6061\/clinics\/2015(07)09.<\/span><\/p>\n<\/td>\n<\/tr>\n [4] Styczynski J. Who Is the Patient at Risk of CMV Recurrence: A Review of the Current Scientific Evidence with a Focus on Hematopoietic Cell Transplantation. Infect Ther. 2017;7:1-16<\/span><\/p>\n<\/td>\n<\/tr>\n [5] Shannon-Lowe & Emery. The effects of Maribavir on the autophosphorylation of ganciclovir resistant mutants of the cytomegalovirus UL97 protein. Herpesviridae 2010, 1:4.<\/span><\/p>\n<\/td>\n<\/tr>\n [6] \u9a6c\u7acb\u5df4\u97e6\u7247\u8bf4\u660e\u4e66<\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table><\/div>\n <\/p>\n","protected":false},"excerpt":{"rendered":" \u6ee1\u8db3\u79fb\u690d\u540e\u5de8\u7ec6\u80de\u75c5\u6bd2\u611f\u67d3\u6cbb\u7597\u4e34\u5e8a\u6025\u9700 \u4e0a\u6d772023\u5e7412\u670821\u65e5 \/\u7f8e\u901a\u793e\/ — \u6b66\u7530\u4e2d\u56fd\u4eca\u65e5\u5ba3\u5e03\uff0c\u65d7\u4e0b\u6297\u75c5\u6bd2\u611f\u67d3\u9886\u57df\u521b\u65b0\u836f\u7269\u9a6c\u7acb\u5df4\u97e6\u7247\uff08\u6291\u6cf0\u4e4b®\uff09\u6b63\u5f0f\u83b7\u5f97\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08NMPA\uff09\u6279\u51c6\uff0c\u9002\u7528\u4e8e\u6cbb\u7597\u9020\u8840\u5e72\u7ec6\u80de\u79fb\u690d\u6216\u5b9e\u4f53\u5668\u5b98\u79fb\u690d\u540e\u5de8\u7ec6\u80de\u75c5\u6bd2(CMV)\u611f\u67d3\u548c\/\u6216\u75be\u75c5\uff0c\u4e14\u5bf9\u4e00\u79cd\u6216\u591a\u79cd\u65e2\u5f80\u6cbb\u7597\uff08\u66f4\u6614\u6d1b\u97e6\u3001\u7f2c\u66f4\u6614\u6d1b\u97e6\u3001\u897f\u591a\u798f\u97e6\u6216\u81a6\u7532\u9178\u94a0\uff09\u96be\u6cbb\uff08\u4f34\u6216\u4e0d\u4f34\u57fa\u56e0\u578b\u8010\u836f\uff09\u7684\u6210\u4eba\u60a3\u8005\u3002\u9a6c\u7acb\u5df4\u97e6\u7247\u662f\u5168\u7403\u9996\u4e2a\u4e14\u76ee\u524d\u552f\u4e00\u4e00\u4e2a\u9776\u5411\u5e76\u6291\u5236UL97\u86cb\u767d\u6fc0\u9176\u53ca\u5176\u5929\u7136\u5e95\u7269\u7684\u6297\u75c5\u6bd2\u5236\u5242[1]\uff0c\u5176\u83b7\u6279\u5c06\u4e3a\u4e2d\u56fd\u96be\u6cbb\u6027CMV\u611f\u67d3\u6216\u75be\u75c5\u7684\u79fb\u690d\u53d7\u8005\u63d0\u4f9b\u4e00\u79cd\u5168\u65b0\u7684\u53e3\u670d\u6cbb\u7597\u9009\u62e9\u30022021\u5e741\u6708\uff0c\u9a6c\u7acb\u5df4\u97e6\u7247\u88ab\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u836f\u54c1\u5ba1\u8bc4\u4e2d\u5fc3\u6b63\u5f0f\u8ba4\u5b9a\u4e3a"\u7a81\u7834\u6027\u6cbb\u7597\u836f\u7269\u54c1\u79cd"\u3002 \u6b66\u7530\u5236\u836f\u5168\u7403\u9ad8\u7ea7\u526f\u603b\u88c1\u3001\u6b66\u7530\u4e2d\u56fd\u603b\u88c1\u5355\u56fd\u6d2a\u5148\u751f\u8868\u793a\uff1a"\u611f\u8c22\u653f\u5e9c\u76f8\u5173\u90e8\u95e8\u8fd1\u5e74\u6765\u9f13\u52b1\u521b\u65b0\u836f\u7269\u7684\u4e00\u7cfb\u5217\u5229\u597d\u653f\u7b56\uff0c\u4f7f\u9a6c\u7acb\u5df4\u97e6\u7247\u80fd\u591f\u901a\u8fc7\u4f18\u5148\u5ba1\u8bc4\u5ba1\u6279\u5728\u4e2d\u56fd\u5feb\u901f\u83b7\u6279\u3002\u8fd9\u662f\u4e00\u4e2a\u91cd\u8981\u7684\u91cc\u7a0b\u7891\uff0c\u6b64\u6b21\u83b7\u6279\u5c06\u5f7b\u5e95\u6539\u53d8\u79fb\u690d\u60a3\u8005\u53d1\u751fCMV\u611f\u67d3\u540e\u7684\u8bca\u7597\u56f0\u5883\uff0c\u4e3a\u4e2d\u56fd\u60a3\u8005\u5e26\u6765\u65b0\u7684\u751f\u5b58\u5e0c\u671b\u3002\u672a\u6765\uff0c\u6b66\u7530\u5c06\u7ee7\u7eed\u52a0\u901f\u5f15\u5165\u66f4\u591a\u5168\u7403\u521b\u65b0\u4ea7\u54c1\uff0c\u8ba9\u4e2d\u56fd\u60a3\u8005\u5c3d\u65e9\u4ece\u9ad8\u5ea6\u521b\u65b0\u7684\u836f\u7269\u548c\u53d8\u9769\u6027\u7684\u7597\u6cd5\u4e2d\u83b7\u76ca\u3002" CMV\u662f\u4e00\u79cd\u5e38\u89c1\u7684\u03b2-\u75b1\u75b9\u75c5\u6bd2\uff0c\u53ef\u572840%-100%\u7684\u6210\u4eba\u4eba\u7fa4\u4e2d\u53d1\u73b0\u65e2\u5f80\u611f\u67d3\u7684\u8840\u6e05\u5b66\u8bc1\u636e[2]\u3002\u5728\u5168\u7403\u6bcf\u5e7420\u4e07\u4f8b\u6210\u4eba\u79fb\u690d\u75c5\u4f8b\u4e2d\uff0cCMV\u662f\u79fb\u690d\u53d7\u8005\u6700\u5e38\u89c1\u7684\u75c5\u6bd2\u611f\u67d3\u4e4b\u4e00\uff0c\u5728\u5b9e\u4f53\u5668\u5b98\u79fb\u690d\u53d7\u8005\u4e2d\u7684\u53d1\u751f\u7387\u4e3a16-56%\uff0c\u5728\u9020\u8840\u5e72\u7ec6\u80de\u79fb\u690d\u53d7\u8005\u4e2d\u7684\u53d1\u751f\u7387\u4e3a30-70%[3],[4],[5]\u3002\u5bf9\u4e8e\u514d\u75ab\u529f\u80fd\u4f4e\u4e0b\u7684\u60a3\u8005\uff0cCMV\u611f\u67d3\u53ef\u80fd\u4f1a\u5371\u53ca\u751f\u547d\u3002\u5728\u7ecf\u5386\u9020\u8840\u5e72\u7ec6\u80de\u79fb\u690d\u6216\u5b9e\u4f53\u5668\u5b98\u79fb\u690d\u540e\uff0c\u60a3\u8005\u4e0d\u53ef\u907f\u514d\u4f1a\u56e0\u5e94\u7528\u514d\u75ab\u6291\u5236\u5242\u800c\u5bfc\u81f4\u514d\u75ab\u7cfb\u7edf\u53d7\u635f\u3002\u6b64\u65f6, \u5982\u679c\u53d1\u751f\u4e86CMV\u611f\u67d3\u53ef\u80fd\u4f1a\u5bfc\u81f4\u79fb\u690d\u5931\u8d25\u7b49\u4e25\u91cd\u540e\u679c\uff0c\u5728\u6781\u7aef\u60c5\u51b5\u4e0b\u751a\u81f3\u4f1a\u5bfc\u81f4\u60a3\u8005\u6b7b\u4ea1\uff0c\u56e0\u6b64CMV\u4e5f\u88ab\u79f0\u4e3a\u2018\u79fb\u690d\u7684\u5de8\u9b54’\u3002 \u76ee\u524d\uff0c\u6cbb\u7597\u79fb\u690d\u540eCMV\u611f\u67d3\u7684\u73b0\u6709\u6cbb\u7597\u65b9\u6848\u53ef\u80fd\u4f1a\u5e26\u6765\u4e25\u91cd\u7684\u526f\u4f5c\u7528\uff0c\u4e5f\u53ef\u80fd\u65e0\u6cd5\u5145\u5206\u6291\u5236\u75c5\u6bd2\u590d\u5236\u3002\u6b64\u5916\uff0c\u7531\u4e8e\u7ed9\u836f\u65b9\u5f0f\u7684\u539f\u56e0\uff0c\u73b0\u6709\u6cbb\u7597\u65b9\u6848\u53ef\u80fd\u4f1a\u8981\u6c42\u60a3\u8005\u4f4f\u9662\u6216\u8005\u5ef6\u957f\u60a3\u8005\u7684\u4f4f\u9662\u65f6\u95f4\uff0c\u60a3\u8005\u75be\u75c5\u8d1f\u62c5\u5927\u5927\u589e\u52a0\uff0c\u56e0\u6b64\u4e34\u5e8a\u4e0a\u8feb\u5207\u9700\u8981\u521b\u65b0\u7597\u6548\u597d\u4e14\u5b89\u5168\u6027\u9ad8\u7684\u6cbb\u7597\u836f\u7269\u3002 \u9a6c\u7acb\u5df4\u97e6\u7247\u662f\u4e00\u79cd\u53e3\u670d\u6297CMV\u521b\u65b0\u836f\uff0c\u4ee5CMV UL97\u86cb\u767d\u6fc0\u9176\u4e3a\u9776\u70b9\uff0c\u4e09\u91cd\u6291\u5236\u75c5\u6bd2DNA\u7684\u590d\u5236\u3001\u8863\u58f3\u5316\u548c\u6838\u9003\u9038, \u4ece\u800c\u6e05\u9664CMV\u8840\u75c7\u5e76\u63a7\u5236\u76f8\u5173\u75c7\u72b6\u3002\u5728\u4e00\u9879\u591a\u4e2d\u5fc3\u3001\u968f\u673a\u3001\u5f00\u653e\u6807\u7b7e\u3001\u9633\u6027\u836f\u7269\u5bf9\u7167\u7684\u2162\u671f\u4f18\u6548\u6027\u7814\u7a76\uff08TAK-620-303\uff09\u4e2d\uff0c\u7ed3\u679c\u663e\u793a\u670955.7% (n=131\/235) \u63a5\u53d7\u9a6c\u7acb\u5df4\u97e6\u7247\u6cbb\u7597\u7684\u60a3\u8005\u5728\u7b2c8 \u5468\u8fbe\u5230\u4e86CMV\u8840\u75c7\u7684\u6e05\u9664\uff08\u5373\u6839\u636e\u4e2d\u5fc3\u5b9e\u9a8c\u5ba4\u7ed3\u679c\uff0c\u95f4\u9694\u81f3\u5c115\u5929\u76842\u4e2a\u8fde\u7eed\u57fa\u7ebf\u540e\u6837\u672c\u7684\u8840\u6d46CMV DNA\u6d53\u5ea6\u4f4e\u4e8e\u5b9a\u91cf\u4e0b\u9650\uff09\uff0c\u800c\u63a5\u53d7\u5e38\u89c4\u6cbb\u7597\u7684\u60a3\u8005\u4e3a 23.9%(n=28\/117)\uff08\u6821\u6b63\u540e\u7684\u5dee\u5f02 [95% \u7f6e\u4fe1\u533a\u95f4(CI)]\uff1a32.8% [22.80\u201342.74]\uff1bP <0.001\uff09[6]\u3002\u540c\u65f6\uff0c\u9a6c\u7acb\u5df4\u97e6\u7247\u4e0e\u5e38\u89c4\u6297\u75c5\u6bd2\u6cbb\u7597\u76f8\u6bd4\uff0c\u6cbb\u7597\u76f8\u5173\u6bd2\u6027\u66f4\u4f4e\u3002\u7814\u7a76\u7ed3\u679c\u663e\u793a\uff0c\u670925%(n=14\/56)\u63a5\u53d7\u7f2c\u66f4\u6614\u6d1b\u97e6\/\u66f4\u6614\u6d1b\u97e6\u6cbb\u7597\u7684\u60a3\u8005\u53d1\u751f\u6cbb\u7597\u76f8\u5173\u7684\u4e2d\u6027\u7c92\u7ec6\u80de\u51cf\u5c11\uff0c\u800c\u63a5\u53d7\u9a6c\u7acb\u5df4\u97e6\u6cbb\u7597\u7684\u60a3\u8005\u4ec5\u4e3a1.7% (n=4\/234)\u3002\u540c\u65f6\uff0c\u670919.1%(n=9\/47)\u63a5\u53d7\u81a6\u7532\u9178\u94a0\u6cbb\u7597\u7684\u60a3\u8005\u53d1\u751f\u4e86\u6025\u6027\u80be\u635f\u4f24\uff0c\u800c\u63a5\u53d7\u9a6c\u7acb\u5df4\u97e6\u6cbb\u7597\u7684\u60a3\u8005\u4ec5\u4e3a1.7% (n=4\/234)\u3002 \u6b66\u7530\u7814\u53d1\u5168\u7403\u526f\u603b\u88c1\uff0c\u4e9a\u592a\u7814\u53d1\u8d1f\u8d23\u4eba\u738b\u7498\u535a\u58eb\u8868\u793a\uff1a"\u79c9\u6301\u60a3\u8005\u4e3a\u5148\u7684\u7406\u5ff5\uff0c\u6211\u4eec\u975e\u5e38\u6b23\u559c\u5730\u770b\u5230\u9a6c\u7acb\u5df4\u97e6\u7247\u5728\u4e2d\u56fd\u6210\u529f\u83b7\u6279\u3002\u9a6c\u7acb\u5df4\u97e6\u7247\u5177\u6709\u65b0\u578b\u6297\u5de8\u7ec6\u80de\u75c5\u6bd2\uff08CMV\uff09\u4f5c\u7528\u673a\u5236\uff0c\u5c06\u4ece\u6839\u672c\u4e0a\u6539\u53d8\u79fb\u690d\u540e\u96be\u6cbb\u6027\uff08\u4f34\u6216\u4e0d\u4f34\u8010\u836f\u6027\uff09\u5de8\u7ec6\u80de\u75c5\u6bd2\u611f\u67d3\u6216\u75be\u75c5\u7684\u6cbb\u7597\u65b9\u5f0f\uff0c\u4e3a\u4e2d\u56fd\u60a3\u8005\u5e26\u6765\u65b0\u7684\u7a81\u7834\u6027\u6cbb\u7597\u9009\u62e9\u3002\u672a\u6765\uff0c\u6b66\u7530\u5c06\u7ee7\u7eed\u53d1\u6325\u5176\u521b\u65b0\u7814\u53d1\u5b9e\u529b\uff0c\u4ee5\u79d1\u5b66\u4e3a\u57fa\u7840\uff0c\u901a\u8fc7\u5c06\u4e2d\u56fd\u60a3\u8005\u7684\u672a\u5c3d\u9700\u6c42\u66f4\u65e9\u7684\u7eb3\u5165\u5168\u7403\u65e9\u671f\u7814\u53d1\u7b56\u7565\u4e2d\uff0c\u8fdb\u4e00\u6b65\u52a0\u901f\u5168\u7403\u521b\u65b0\u836f\u7269\u7684\u83b7\u6279\uff0c\u60e0\u53ca\u66f4\u591a\u4e2d\u56fd\u60a3\u8005\u3002" \u9a6c\u7acb\u5df4\u97e6\u7247\u76ee\u524d\u5df2\u5728\u7f8e\u56fd\u3001\u6b27\u6d32\u3001\u97e9\u56fd\u548c\u6fb3\u5927\u5229\u4e9a\u83b7\u5f97\u5b64\u513f\u836f\u8d44\u683c\u8ba4\u5b9a\uff0c\u5206\u522b\u4e8e2021\u5e7411\u6708\u83b7\u5f97\u7f8e\u56fd\u98df\u54c1\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08FDA\uff09\u6279\u51c6\u4e0a\u5e02\uff0c\u4e8e2022\u5e7411\u6708\uff0c\u83b7\u5f97\u6b27\u76df\u59d4\u5458\u4f1a\uff08EC\uff09\u6279\u51c6\u4e0a\u5e02\u3002 \u5ba1\u6279\u7f16\u53f7\uff1aC-ANPROM\/CN\/MARI\/0022\u5ba1\u6279\u65e5\u671f\uff1a2023\u5e7412\u6708 \u58f0\u660e \u672c\u6587\u6240\u5305\u542b\u7684\u836f\u54c1\u4fe1\u606f\u53ef\u80fd\u5e76\u975e\u5728\u6240\u6709\u56fd\u5bb6\/\u5730\u533a\u9002\u7528\uff0c\u6216\u5728\u4e0d\u540c\u7684\u56fd\u5bb6\/\u5730\u533a\u53ef\u80fd\u9002\u7528\u4e0d\u540c\u7684\u5546\u6807\u3001\u9002\u5e94\u75c7\u6216\u60a3\u8005\u4f7f\u7528\u5242\u91cf\u3002 \u672c\u6587\u65e8\u5728\u4f20\u9012\u533b\u836f\u524d\u6cbf\u4fe1\u606f\uff0c\u4e0d\u6784\u6210\u5bf9\u4efb\u4f55\u836f\u7269\u6216\u8bca\u7597\u65b9\u6848\u7684\u63a8\u8350\u6216\u63a8\u5e7f\u3002 \u5982\u60a8\u60f3\u4e86\u89e3\u66f4\u591a\u75be\u75c5\u77e5\u8bc6\u6216\u836f\u54c1\u3001\u8bca\u7597\u76f8\u5173\u4fe1\u606f\uff0c\u8bf7\u54a8\u8be2\u533b\u7597\u536b\u751f\u4e13\u4e1a\u4eba\u58eb\u3002 \u5173\u4e8e\u6b66\u7530\u5236\u836f \u6b66\u7530\u5236\u836f\uff08\u4e1c\u4eac\u8bc1\u5238\u4ea4\u6613\u6240\u80a1\u7968\u4ee3\u7801\uff1a4502\uff09\uff08\u7ebd\u7ea6\u8bc1\u5238\u4ea4\u6613\u6240\u80a1\u7968\u4ee3\u7801\uff1aTAK\uff09\u662f\u4e00\u5bb6\u603b\u90e8\u4f4d\u4e8e\u65e5\u672c\u3001\u4ee5\u4ef7\u503c\u89c2\u4e3a\u57fa\u7840\u3001\u4ee5\u7814\u53d1\u4e3a\u9a71\u52a8\u7684\u5168\u7403\u751f\u7269\u5236\u836f\u516c\u53f8\u3002\u6b66\u7530\u81f4\u529b\u4e8e\u5c06\u79d1\u5b66\u7814\u53d1\u6210\u679c\u8f6c\u5316\u4e3a\u9ad8\u5ea6\u521b\u65b0\u836f\u54c1\uff0c\u4e3a\u60a3\u8005\u7684\u5065\u5eb7\u751f\u6d3b\u548c\u7f8e\u597d\u672a\u6765\u4fdd\u9a7e\u62a4\u822a\u3002\u6b66\u7530\u4e13\u6ce8\u4e8e\u56db\u5927\u6cbb\u7597\u9886\u57df\u7684\u836f\u7269\u7814\u53d1\uff1a\u80bf\u7624\u3001\u6d88\u5316\u3001\u795e\u7ecf\u79d1\u5b66\u53ca\u7f55\u89c1\u75c5\u9886\u57df\uff0c\u5e76\u9488\u5bf9\u8840\u6db2\u5236\u54c1\u53ca\u75ab\u82d7\u9886\u57df\u8fdb\u884c\u4e13\u9879\u7814\u53d1\u6295\u5165\u3002\u6211\u4eec\u59cb\u7ec8\u4e13\u6ce8\u4e8e\u9ad8\u5ea6\u521b\u65b0\u836f\u7269\u7684\u7814\u53d1\uff0c\u901a\u8fc7\u5f00\u62d3\u5168\u65b0\u6cbb\u7597\u65b9\u6848\u3001\u589e\u5f3a\u5408\u4f5c\u7814\u53d1\u5f15\u64ce\u5b9e\u529b\uff0c\u6253\u9020\u4e00\u6761\u7a33\u5065\u4e14\u5f62\u5f0f\u591a\u6837\u7684\u4ea7\u54c1\u7ba1\u7ebf\uff0c\u52a9\u529b\u6539\u5584\u4eba\u4eec\u7684\u751f\u6d3b\u3002\u6211\u4eec\u7684\u5458\u5de5\u904d\u5e03\u4e8e\u5927\u7ea680\u4e2a\u56fd\u5bb6\u548c\u5730\u533a\uff0c\u4e0e\u5f53\u5730\u533b\u7597\u5065\u5eb7\u5408\u4f5c\u4f19\u4f34\u643a\u624b\uff0c\u4e3a\u5168\u7403\u60a3\u8005\u5e26\u6765\u5065\u5eb7\u798f\u97f3\u3002 \u6b66\u7530\u4e8e1994\u5e74\u8fdb\u5165\u4e2d\u56fd\uff0c\u6b66\u7530\u4e2d\u56fd\u603b\u90e8\u4f4d\u4e8e\u4e0a\u6d77\uff0c\u5728\u4e2d\u56fd\u5927\u9646\u7684\u4e3b\u8981\u4e1a\u52a1\u4e2d\u5fc3\u4f4d\u4e8e\u5317\u4eac\u3001\u4e0a\u6d77\u3001\u5929\u6d25\u3001\u5e7f\u5dde\u3001\u9999\u6e2f\u7279\u522b\u884c\u653f\u533a\u7b49\u57ce\u5e02\u548c\u5730\u533a\uff0c\u5e76\u5728\u5168\u56fd\u5404\u4e3b\u8981\u57ce\u5e02\u8bbe\u6709\u529e\u4e8b\u5904\uff0c\u76ee\u524d\u5728\u4e2d\u56fd\u62e5\u6709\u8d85\u8fc72000\u540d\u5458\u5de5\u3002\u968f\u7740\u4e2d\u56fd\u7ecf\u6d4e\u7684\u53d1\u5c55\u548c\u5bf9\u533b\u7597\u4fdd\u5065\u9700\u6c42\u7684\u4e0d\u65ad\u589e\u957f\uff0c\u4e2d\u56fd\u5df2\u7ecf\u6210\u4e3a\u6b66\u7530\u5168\u7403\u6700\u91cd\u8981\u7684\u65b0\u5174\u5e02\u573a\u4e4b\u4e00\u3002 \u66f4\u591a\u4fe1\u606f\uff0c\u656c\u8bf7\u8bbf\u95eehttps:\/\/www.takeda.com \u524d\u77bb\u6027\u58f0\u660e \u672c\u7a3f\u4ef6\u53ca\u4e0e\u4e4b\u76f8\u5173\u7684\u6240\u5206\u53d1\u7684\u4efb\u4f55\u8d44\u6599\u53ef\u80fd\u542b\u6709\u4e0e\u6b66\u7530\u672a\u6765\u4e1a\u52a1\u3001\u672a\u6765\u72b6\u51b5\u548c\u8fd0\u8425\u4e1a\u7ee9\u6709\u5173\u7684\u524d\u77bb\u6027\u9648\u8ff0\u3001\u770b\u6cd5\u6216\u610f\u89c1\uff0c\u5305\u62ec\u6b66\u7530\u7684\u9884\u4f30\u3001\u9884\u6d4b\u3001\u76ee\u6807\u548c\u8ba1\u5212\u3002\u524d\u77bb\u6027\u9648\u8ff0\u5e38\u5e38\u5305\u542b\u4f46\u4e0d\u9650\u4e8e\u4e0b\u5217\u63aa\u8f9e\uff0c\u4f8b\u5982"\u76ee\u6807"\u3001"\u8ba1\u5212"\u3001"\u8ba4\u4e3a"\u3001"\u5e0c\u671b"\u3001"\u7ee7\u7eed"\u3001"\u9884\u8ba1"\u3001"\u65e8\u5728"\u3001"\u6253\u7b97"\u3001"\u786e\u4fdd"\u3001"\u5c06"\u3001"\u53ef\u80fd"\u3001"\u5e94"\u3001"\u4f1a"\u3001"\u6216\u8bb8"\u3001"\u9884\u671f"\u3001"\u4f30\u8ba1"\u3001"\u9884\u6d4b"\u6216\u7c7b\u4f3c\u8868\u8ff0\u6216\u5176\u5426\u5b9a\u5f62\u5f0f\u3002 \u672c\u6587\u4e2d\u7684\u524d\u77bb\u6027\u9648\u8ff0\u4ec5\u57fa\u4e8e\u6b66\u7530\u622a\u81f3\u53d1\u5e03\u65e5\u671f\u7684\u4f30\u8ba1\u548c\u5047\u8bbe\u3002\u6b64\u7c7b\u524d\u77bb\u6027\u58f0\u660e\u5e76\u975e\u662f\u6b66\u7530\u6216\u5176\u7ba1\u7406\u5c42\u5bf9\u672a\u6765\u4e1a\u7ee9\u6240\u505a\u7684\u4efb\u4f55\u4fdd\u8bc1\uff0c\u5e76\u6d89\u53ca\u5df2\u77e5\u548c\u672a\u77e5\u7684\u98ce\u9669\u3001\u4e0d\u786e\u5b9a\u6027\u548c\u5176\u4ed6\u56e0\u7d20\uff0c\u5305\u62ec\u4f46\u4e0d\u9650\u4e8e\uff1a\u6b66\u7530\u5168\u7403\u4e1a\u52a1\u6240\u9762\u4e34\u7684\u7ecf\u6d4e\u5f62\u52bf\uff0c\u5305\u62ec\u65e5\u672c\u548c\u7f8e\u56fd\u7684\u5b8f\u89c2\u7ecf\u6d4e\u73af\u5883\uff1b\u7ade\u4e89\u538b\u529b\u548c\u53d1\u5c55\u60c5\u51b5\uff1b\u9002\u7528\u6cd5\u5f8b\u6cd5\u89c4\u7684\u53d8\u52a8\uff1b\u4ea7\u54c1\u5f00\u53d1\u9879\u76ee\u7684\u6210\u529f\u6216\u5931\u8d25\uff1b\u76d1\u7ba1\u5f53\u5c40\u7684\u51b3\u7b56\u6216\u505a\u51fa\u51b3\u7b56\u7684\u65f6\u673a\uff1b\u5229\u7387\u548c\u6c47\u7387\u6ce2\u52a8\uff1b\u6709\u5173\u5df2\u552e\u4ea7\u54c1\u6216\u5019\u9009\u4ea7\u54c1\u5b89\u5168\u6216\u529f\u6548\u7684\u7d22\u8d54\u6216\u7591\u95ee\uff1b\u5df2\u6536\u8d2d\u516c\u53f8\u7684\u5408\u5e76\u540e\u6574\u5408\u52aa\u529b\u7684\u65f6\u673a\u548c\u5f71\u54cd\uff1b\u4ee5\u53ca\u80fd\u5426\u5265\u79bb\u5bf9\u6b66\u7530\u8fd0\u8425\u975e\u6838\u5fc3\u7684\u8d44\u4ea7\u548c\u4efb\u4f55\u6b64\u7c7b\u5265\u79bb\u7684\u65f6\u673a\uff0c\u6240\u6709\u8fd9\u4e9b\u90fd\u53ef\u80fd\u4f1a\u5bfc\u81f4\u6b66\u7530\u7684\u5b9e\u9645\u4e1a\u7ee9\u3001\u8868\u73b0\u3001\u6210\u5c31\u6216\u8d22\u52a1\u72b6\u51b5\u4e0e\u6b64\u7c7b\u524d\u77bb\u6027\u9648\u8ff0\u6240\u63cf\u8ff0\u6216\u6697\u6307\u7684\u4efb\u4f55\u672a\u6765\u4e1a\u7ee9\u3001\u8868\u73b0\u3001\u6210\u5c31\u6216\u8d22\u52a1\u72b6\u51b5\u53d1\u751f\u91cd\u5927\u504f\u5dee\u3002 \u5173\u4e8e\u4ee5\u4e0a\u53ca\u53ef\u80fd\u5f71\u54cd\u6b66\u7530\u7ed3\u679c\u3001\u4e1a\u7ee9\u3001\u6210\u5c31\u6216\u8d22\u52a1\u72b6\u51b5\u7684\u5176\u4ed6\u56e0\u7d20\u7684\u66f4\u591a\u4fe1\u606f\uff0c\u8bf7\u53c2\u9605\u6b66\u7530\u5411\u7f8e\u56fd\u8bc1\u5238\u4ea4\u6613\u59d4\u5458\u4f1a\u63d0\u4ea4\u7684Form 20-F\u6700\u65b0\u5e74\u62a5"\u7b2c3\u9879. \u5173\u952e\u4fe1\u606f\u2014D. \u98ce\u9669\u56e0\u7d20"\u548c\u5176\u4ed6\u62a5\u544a\uff0c\u5177\u4f53\u8bf7\u67e5\u9605\u6b66\u7530\u7f51\u7ad9https:\/\/www.takeda.com\/investors\/reports\/sec-filings\/\u6216www.sec.gov\u3002\u6b66\u7530\u7684\u672a\u6765\u7ed3\u679c\u3001\u4e1a\u7ee9\u6210\u5c31\u6216\u8d22\u52a1\u5730\u4f4d\u53ef\u80fd\u4e0e\u524d\u77bb\u6027\u9648\u8ff0\u6240\u8a00\u4f20\u6216\u610f\u4f1a\u7684\u5185\u5bb9\u6709\u5b9e\u8d28\u6027\u5dee\u8ddd\u3002\u6536\u5230\u8fd9\u4e00\u65b0\u95fb\u7a3f\u7684\u4e2a\u4eba\u4e0d\u5e94\u5bf9\u4efb\u4f55\u524d\u77bb\u6027\u9648\u8ff0\u5bc4\u4e88\u4e0d\u9002\u5207\u7684\u4f9d\u8d56\u3002\u6b66\u7530\u6ca1\u6709\u4e49\u52a1\u66f4\u65b0\u672c\u65b0\u95fb\u7a3f\u4e2d\u7684\u4efb\u4f55\u524d\u77bb\u6027\u9648\u8ff0\u6216\u516c\u53f8\u53ef\u80fd\u53d1\u5e03\u7684\u4efb\u4f55\u5176\u4ed6\u524d\u77bb\u6027\u9648\u8ff0\uff0c\u9664\u975e\u662f\u6cd5\u5f8b\u6216\u8bc1\u5238\u4ea4\u6613\u89c4\u5219\u6240\u8981\u6c42\u3002\u5386\u53f2\u4e1a\u7ee9\u5e76\u4e0d\u80fd\u4ee3\u8868\u672a\u6765\u4e1a\u7ee9\uff0c\u800c\u4e14\u672c\u65b0\u95fb\u7a3f\u4e2d\u7684\u6b66\u7530\u4e1a\u7ee9\u5e76\u4e0d\u80fd\u6307\u4ee3\uff0c\u4e5f\u5e76\u975e\u662f\u6b66\u7530\u672a\u6765\u4e1a\u7ee9\u7684\u9884\u4f30\u3001\u9884\u6d4b\u6216\u63a8\u6d4b\u3002 [1] Avram S, et al. Novel drug targets in 2021. Nat. Rev. Drug Discov.… Read More<\/a><\/p>\n","protected":false},"author":556,"featured_media":0,"comment_status":"close","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1965],"tags":[],"class_list":["post-101103","post","type-post","status-publish","format-standard","hentry","category-partnerships"],"amp_enabled":true,"_links":{"self":[{"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/posts\/101103","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/users\/556"}],"replies":[{"embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/comments?post=101103"}],"version-history":[{"count":1,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/posts\/101103\/revisions"}],"predecessor-version":[{"id":101104,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/posts\/101103\/revisions\/101104"}],"wp:attachment":[{"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/media?parent=101103"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/categories?post=101103"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/tags?post=101103"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
\u5ba1\u6279\u65e5\u671f\uff1a2023\u5e7412\u6708<\/p>\n\n
\n\n
\n \n \n \n \n \n \n \n \n \n \n \n