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\"\"<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\u6d4e\u5357<\/span>2023\u5e7412\u67088\u65e5<\/span> \/\u7f8e\u901a\u793e\/ — 12\u67086-8\u65e5\uff0c\u6b27\u6d32\u80bf\u7624\u5185\u79d1\u5b66\u4f1a\u514d\u75ab\u80bf\u7624\u5b66\uff08ESMO Immuno-Oncology\uff09\u5927\u4f1a\u5728\u745e\u58eb\u65e5\u5185\u74e6\u53ec\u5f00\uff0c\u9f50\u9c81\u5236\u836f\u4ee5\u58c1\u62a5\u5f62\u5f0f\u62a5\u544a\u4e86QLS31905\u5728\u665a\u671f\u5b9e\u4f53\u7624\u60a3\u8005\u4e2d\u7684I\u671f\u4e34\u5e8a\u8bd5\u9a8c\u6700\u65b0\u7814\u7a76\u7ed3\u679c\uff08\u58c1\u62a5\u7f16\u53f7\uff1a132P\uff09\u3002\u4e3b\u8981\u7814\u7a76\u8005\u4e3a\u5317\u4eac\u5927\u5b66\u80bf\u7624\u533b\u9662\u7684\u6c88\u7433\u6559\u6388\u3002<\/p>\n

QLS31905\u662f\u7531\u9f50\u9c81\u5236\u836f\u81ea\u4e3b\u7814\u53d1\u7684\u9776\u5411Claudin18.2\u7684\u53cc\u7279\u5f02\u6027T\u7ec6\u80de\u8854\u63a5\u5668\uff08Bispeific T cell Engager\uff09\u3002\u672c\u7814\u7a76\u7684\u4e3b\u8981\u76ee\u7684\u662f\u63a2\u7d22QLS31905\u5728\u665a\u671f\u5b9e\u4f53\u7624\u60a3\u8005\u4e2d\u5b89\u5168\u6027\u3001\u8010\u53d7\u6027\uff0c\u4ee5\u53ca\u521d\u6b65\u7684\u6297\u80bf\u7624\u6d3b\u6027\u3002<\/p>\n

\u7814\u7a76\u80cc\u666f\u548c\u8bbe\u8ba1<\/b>\uff1a<\/p>\n

Claudin18.2\u662f\u5177\u6709\u9ad8\u5ea6\u7279\u5f02\u6027\u7684\u7ec6\u80de\u8868\u9762\u5206\u5b50\uff0c\u5176\u5f02\u5e38\u6fc0\u6d3b\u8868\u8fbe\u5e38\u89c1\u4e8e\u539f\u53d1\u6027\u80c3\u764c\u4ee5\u53ca\u80f0\u817a\u764c\u3001\u98df\u7ba1\u764c\u7b49\u5b9e\u4f53\u7624[1],[2]<\/span><\/sup>\u3002QLS31905\u4e0e\u80bf\u7624\u7ec6\u80de\u8868\u9762\u7684Claudin18.2\u548cT\u7ec6\u80de\u8868\u9762\u7684CD3\u7ed3\u5408\uff0c\u901a\u8fc7\u52df\u96c6\u548c\u6fc0\u6d3b\u80bf\u7624\u7ec6\u80de\u9644\u8fd1\u7684T\u7ec6\u80de\uff0c\u5bf9\u80bf\u7624\u7ec6\u80de\u8fdb\u884c\u6301\u7eed\u5730\u6740\u4f24\u88c2\u89e3\u3002\u672c\u7814\u7a76\u7eb3\u5165\u6807\u51c6\u6cbb\u7597\u5931\u8d25\u6216\u4e0d\u9002\u7528\u6216\u65e0\u6807\u51c6\u6cbb\u7597\u7684\u665a\u671f\u5b9e\u4f53\u7624\u60a3\u8005\u3002\u7814\u7a76\u5206\u4e3a\u5242\u91cf\u9012\u589e\u548c\u5242\u91cf\u62d3\u5c55\u4e24\u4e2a\u9636\u6bb5\u3002\u5242\u91cf\u9012\u589e\u9636\u6bb5\u91c7\u7528\u52a0\u901f\u6ef4\u5b9a\u548ci3+3\u7684\u7814\u7a76\u8bbe\u8ba1\uff0cQLS31905\u5355\u6b21\u7ed9\u836f\u5242\u91cf\u6309\u71670.5\u03bcg\/kg QW\u30011.5\u03bcg\/kg QW\u30015\u03bcg\/kg QW\u300115\u03bcg\/kg QW\u300145\u03bcg\/kg QW\u3001100\u03bcg\/kg QW\u3001200\u03bcg\/kg QW\u3001350\u03bcg\/kg QW\u3001500 \u03bcg\/kg Q2W\u9012\u589e\uff0c\u4e3b\u8981\u7ec8\u70b9\u662f\u5242\u91cf\u9650\u5236\u6bd2\u6027\uff08DLT\uff09\u548c\u6700\u5927\u8010\u53d7\u5242\u91cf\uff08MTD\uff09\uff0c\u6b21\u8981\u7ec8\u70b9\u662f\u5b89\u5168\u6027\u3001\u836f\u4ee3\u52a8\u529b\u5b66\u548c\u836f\u6548\u52a8\u529b\u5b66\u3001\u514d\u75ab\u539f\u6027\u3002\u5242\u91cf\u62d3\u5c55\u9636\u6bb5\u7684\u4e3b\u8981\u7ec8\u70b9\u662f\u5ba2\u89c2\u7f13\u89e3\u7387\uff08ORR\uff09\uff0c\u6b21\u8981\u7ec8\u70b9\u662f\u75be\u75c5\u63a7\u5236\u7387\uff08DCR\uff09\u3001\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff08PFS\uff09\u3001\u603b\u4f53\u751f\u5b58\u671f\uff08OS\uff09\u3002<\/p>\n

\n

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\u7814\u7a76\u7ed3\u679c<\/b>\uff1a<\/p>\n

\u622a\u6b622023\u5e747\u670817\u65e5\uff0c\u5171\u8ba1\u7eb3\u516552\u4f8b\u53d7\u8bd5\u8005\uff0c\u5305\u62ec31\u4f8b\u80c3\u764c\u548c12\u4f8b\u80f0\u817a\u764c\u60a3\u8005\u3002\u5242\u91cf\u9012\u589e\u9636\u6bb5\uff0c\u5171\u8ba122\u4f8b\u53d7\u8bd5\u8005\u4ece0.5\u03bcg\/kg QW\u722c\u5761\u5230350 \u03bcg\/kg QW\u961f\u5217\uff0c\u76ee\u524d500 \u03bcg\/kg Q2W\u5242\u91cf\u6c34\u5e73\u6b63\u5728\u8fdb\u884c\u4e2d\u3002\u5242\u91cf\u62d3\u5c55\u9636\u6bb5\u91c7\u7528\u4e86200\u03bcg\/kg QW\u548c350\u03bcg\/kg Q2W\u4e24\u4e2a\u5242\u91cf\u6c34\u5e73\uff0c\u5171\u8ba1\u7eb3\u516530\u4f8b\u53d7\u8bd5\u8005\u3002<\/p>\n

\u5b89\u5168\u6027\u65b9\u9762\uff0cDLT\u672a\u53d1\u751f\uff0c\u5c1a\u672a\u786e\u5b9aMTD\u3002\u5171\u8ba121\u4f8b\uff0840.4%\uff09\u53d7\u8bd5\u8005\u53d1\u751f\u4e86\u22653\u7ea7\u7684\u6cbb\u7597\u76f8\u5173\u4e0d\u826f\u4e8b\u4ef6\uff08TRAE\uff09\u300210\u4f8b\uff0819.2%\uff09\u53d7\u8bd5\u8005\u53d1\u751f\u4e86\u6cbb\u7597\u76f8\u5173\u7684\u4e25\u91cd\u4e0d\u826f\u4e8b\u4ef6\u30022\u4f8b\u53d7\u8bd5\u8005\uff083.8%\uff09\u53d1\u751f\u4e86\u5bfc\u81f4\u505c\u6b62\u6cbb\u7597\u7684TRAE\u3002\u6700\u5e38\u89c1\u7684TRAE\u662f\u53d1\u70ed\uff0830\u4f8b\uff0c57.7%\uff09\u3001\u6076\u5fc3\uff0826\u4f8b\uff0c50.0%\uff09\u3001\u767d\u7ec6\u80de\u8ba1\u6570\u964d\u4f4e\uff0818\u4f8b\uff0c34.6%\uff09\u3002350 \u03bcg\/kg QW\u961f\u5217\u4e2d\u76842\u4f8b\u60a3\u8005\u53d1\u751f3\u7ea7\u53ca\u4ee5\u4e0a\u7684\u7ec6\u80de\u56e0\u5b50\u91ca\u653e\u7efc\u5408\u5f81\u3002<\/p>\n

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\u7597\u6548\u65b9\u9762\uff0c\u5728\u7597\u6548\u53ef\u8bc4\u4ef7\u768427\u4f8b\u53d7\u8bd5\u8005\u4e2d\uff0cORR\u4e3a11.1%\uff0cDCR\u4e3a63.0%\u3002\u8fbe\u5230\u90e8\u5206\u7f13\u89e3\uff08PR\uff09\u76843\u4f8b\u60a3\u8005\u4e2d\uff0c2\u4f8b\u4e3a\u80f0\u817a\u764c\uff0c1\u4f8b\u4e3a\u80c6\u56ca\u764c\uff0cClaudin18.2\u8868\u8fbe\u6c34\u5e73\u5747\u4e3a\u4e2d\/\u9ad8\u8868\u8fbe\u3002\u572814\u4f8b\u75be\u75c5\u7a33\u5b9a\uff08SD\uff09\u7684\u60a3\u8005\u4e2d\uff0c8\u4f8b\u9776\u75c5\u7076\u7f29\u5c0f\uff0c\u5176\u4e2d7\u4f8b\u4e3aClaudin18.2\u4e2d\/\u9ad8\u8868\u8fbe\u3002<\/p>\n

\n

\"\"<\/a>
<\/span><\/p>\n<\/p><\/div>\n

\u7efc\u4e0a\uff0cQLS31905\u5728\u665a\u671f\u5b9e\u4f53\u7624\u60a3\u8005\u4e2d\u5c55\u73b0\u51fa\u826f\u597d\u7684\u5b89\u5168\u6027\u3001\u8010\u53d7\u6027\u3001\u4ee5\u53ca\u521d\u6b65\u7684\u6297\u80bf\u7624\u6d3b\u6027\u3002\u76ee\u524dQLS31905\u7684II\u671f\u4e34\u5e8a\u8bd5\u9a8c\u6b63\u5728\u8fdb\u884c\u4e2d\u3002<\/p>\n

\u3010\u53c2\u8003\u6587\u732e\u3011<\/p>\n

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1.    Sahin U, et al. Clin Cancer Res. 2008;14(23):7624-34.<\/span><\/p>\n<\/td>\n<\/tr>\n

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2.    Singh P, et al. J Hematol Oncol. 2017;10(1):105.<\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table><\/div>\n

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\n<\/p><\/div>\n","protected":false},"excerpt":{"rendered":"

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\u7597\u6548\u65b9\u9762\uff0c\u5728\u7597\u6548\u53ef\u8bc4\u4ef7\u768427\u4f8b\u53d7\u8bd5\u8005\u4e2d\uff0cORR\u4e3a11.1%\uff0cDCR\u4e3a63.0%\u3002\u8fbe\u5230\u90e8\u5206\u7f13\u89e3\uff08PR\uff09\u76843\u4f8b\u60a3\u8005\u4e2d\uff0c2\u4f8b\u4e3a\u80f0\u817a\u764c\uff0c1\u4f8b\u4e3a\u80c6\u56ca\u764c\uff0cClaudin18.2\u8868\u8fbe\u6c34\u5e73\u5747\u4e3a\u4e2d\/\u9ad8\u8868\u8fbe\u3002\u572814\u4f8b\u75be\u75c5\u7a33\u5b9a\uff08SD\uff09\u7684\u60a3\u8005\u4e2d\uff0c8\u4f8b\u9776\u75c5\u7076\u7f29\u5c0f\uff0c\u5176\u4e2d7\u4f8b\u4e3aClaudin18.2\u4e2d\/\u9ad8\u8868\u8fbe\u3002 \u7efc\u4e0a\uff0cQLS31905\u5728\u665a\u671f\u5b9e\u4f53\u7624\u60a3\u8005\u4e2d\u5c55\u73b0\u51fa\u826f\u597d\u7684\u5b89\u5168\u6027\u3001\u8010\u53d7\u6027\u3001\u4ee5\u53ca\u521d\u6b65\u7684\u6297\u80bf\u7624\u6d3b\u6027\u3002\u76ee\u524dQLS31905\u7684II\u671f\u4e34\u5e8a\u8bd5\u9a8c\u6b63\u5728\u8fdb\u884c\u4e2d\u3002 \u3010\u53c2\u8003\u6587\u732e\u3011 1.    Sahin U, et al. Clin Cancer Res. 2008;14(23):7624-34. 2.    Singh P, et al. J Hematol Oncol. 2017;10(1):105.  … Read More<\/a><\/p>\n","protected":false},"author":556,"featured_media":100849,"comment_status":"close","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1965],"tags":[],"class_list":["post-100843","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-partnerships"],"amp_enabled":true,"_links":{"self":[{"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/posts\/100843","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/users\/556"}],"replies":[{"embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/comments?post=100843"}],"version-history":[{"count":1,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/posts\/100843\/revisions"}],"predecessor-version":[{"id":100848,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/posts\/100843\/revisions\/100848"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/media\/100849"}],"wp:attachment":[{"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/media?parent=100843"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/categories?post=100843"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/tags?post=100843"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}