–ASC40<\/i>\u6cbb\u7597\u4e2d\u3001\u91cd\u5ea6\u5bfb\u5e38\u6027\u75e4\u75ae\u7684\u2162\u671f\u4e34\u5e8a\u8bd5\u9a8c\u5c06\u5165\u7ec4<\/i>480<\/i>\u4f8b\u53d7\u8bd5\u8005<\/i><\/p>\n
–III<\/i>\u671f\u4e34\u5e8a\u8bd5\u9a8c\u65b9\u6848\u5df2\u83b7\u5f97\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u836f\u54c1\u5ba1\u8bc4\u4e2d\u5fc3\u540c\u610f\uff0c\u5e76\u5df2\u83b7\u5f97\u590d\u65e6\u5927\u5b66\u9644\u5c5e\u534e\u5c71\u533b\u9662\u673a\u6784\u4f26\u7406\u59d4\u5458\u4f1a\u6279\u51c6<\/i> <\/p>\n
—<\/i>\u590d\u65e6\u5927\u5b66\u9644\u5c5e\u534e\u5c71\u533b\u9662\u9879\u857e\u7ea2\u6559\u6388\u62c5\u4efb\u8fd9\u9879<\/i>III<\/i>\u671f\u4e34\u5e8a\u8bd5\u9a8c\u7684\u4e3b\u8981\u7814\u7a76\u8005<\/i><\/p>\n
\u676d\u5dde\u548c\u7ecd\u5174<\/span>2023\u5e7412\u67085\u65e5<\/span> \/\u7f8e\u901a\u793e\/ — \u6b4c\u793c\u5236\u836f\u6709\u9650\u516c\u53f8\uff08\u9999\u6e2f\u8054\u4ea4\u6240\u4ee3\u7801\uff1a1672\uff0c"\u6b4c\u793c"\uff09\u4eca\u65e5\u5ba3\u5e03\u542f\u52a8\u8102\u80aa\u9178\u5408\u6210\u9176\uff08FASN\uff09\u6291\u5236\u5242ASC40\uff08\u5730\u5c3c\u6cd5\u53f8\u4ed6\uff09\u6cbb\u7597\u4e2d\u3001\u91cd\u5ea6\u5bfb\u5e38\u6027\u75e4\u75ae\u7684III\u671f\u4e34\u5e8a\u8bd5\u9a8c\u3002 <\/p>\n \u8fd9\u9879III\u671f\u4e34\u5e8a\u8bd5\u9a8c\u662f\u4e00\u9879\u5728\u4e2d\u56fd\u5f00\u5c55\u7684\u968f\u673a\u3001\u53cc\u76f2\u3001\u5b89\u6170\u5242\u5bf9\u7167\u3001\u591a\u4e2d\u5fc3\u7684\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u65e8\u5728\u8bc4\u4f30ASC40\u6cbb\u7597\u4e2d\u3001\u91cd\u5ea6\u5bfb\u5e38\u6027\u75e4\u75ae\u7684\u5b89\u5168\u6027\u548c\u7597\u6548\u3002480\u4f8b\u4e2d\u3001\u91cd\u5ea6\u5bfb\u5e38\u6027\u75e4\u75ae\u53d7\u8bd5\u8005\u5c06\u88ab\u6309\u71671:1\u7684\u6bd4\u4f8b\u968f\u673a\u5206\u81f3\u4e00\u4e2a\u6d3b\u6027\u836f\u7269\u7ec4\u548c\u4e00\u4e2a\u5b89\u6170\u5242\u5bf9\u7167\u7ec4\uff0c\u63a5\u53d7\u6bcf\u65e5\u4e00\u6b21\u53e3\u670d50\u6beb\u514bASC40\u6216\u5339\u914d\u7684\u5b89\u6170\u5242\u6cbb\u7597\uff0c\u4e3a\u671f12\u5468\u3002<\/p>\n \u4e3b\u8981\u7597\u6548\u7ec8\u70b9\u4e3a\uff1a\u7b2c12\u5468\u65f6\uff0c\u6cbb\u7597\u6210\u529f\u7684\u53d7\u8bd5\u8005\u6bd4\u4f8b\uff0c\u53d7\u8bd5\u8005\u603b\u76ae\u635f\u8ba1\u6570\u76f8\u5bf9\u57fa\u7ebf\u7684\u767e\u5206\u6bd4\u53d8\u5316\uff0c\u4ee5\u53ca\u53d7\u8bd5\u8005\u708e\u6027\u76ae\u635f\u8ba1\u6570\u76f8\u5bf9\u57fa\u7ebf\u7684\u767e\u5206\u6bd4\u53d8\u5316\u3002\u6cbb\u7597\u6210\u529f\u7684\u5b9a\u4e49\u4e3a\uff1a\u7814\u7a76\u8005\u603b\u4f53\u8bc4\u4f30\uff08IGA\uff09\u8bc4\u5206\u8f83\u57fa\u7ebf\u4e0b\u964d\u22652\u5206\uff0c\u4e14IGA\u5206\u7ea7\u4e3a\u5149\u6d01\uff080\u5206\uff09\u6216\u51e0\u4e4e\u5149\u6d01\uff081\u5206\uff09\u3002<\/p>\n III\u671f\u4e34\u5e8a\u8bd5\u9a8c\u65b9\u6848\u5df2\u83b7\u5f97\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u836f\u54c1\u5ba1\u8bc4\u4e2d\u5fc3\u540c\u610f\uff0c\u5e76\u5df2\u83b7\u5f97\u590d\u65e6\u5927\u5b66\u9644\u5c5e\u534e\u5c71\u533b\u9662\u673a\u6784\u4f26\u7406\u59d4\u5458\u4f1a\u6279\u51c6\u3002<\/p>\n 2023\u5e745\u67082\u65e5\uff0c\u6b4c\u793c\u5ba3\u5e03ASC40\u6cbb\u7597\u5bfb\u5e38\u6027\u75e4\u75ae\u7684II\u671f\u4e34\u5e8a\u8bd5\u9a8c\u8fbe\u5230\u4e3b\u8981\u53ca\u5173\u952e\u6b21\u8981\u7ec8\u70b9\uff0c\u8868\u73b0\u51fa\u4e86\u663e\u8457\u7684\u7597\u6548\u548c\u826f\u597d\u7684\u5b89\u5168\u6027\u3002<\/p>\n ASC40\u662f\u4e00\u79cd\u53e3\u670d\u3001\u9009\u62e9\u6027\u5c0f\u5206\u5b50FASN\u6291\u5236\u5242\u3002ASC40\u6cbb\u7597\u75e4\u75ae\u7684\u673a\u5236\u662f\uff1a\uff081\uff09\u901a\u8fc7\u6291\u5236\u4eba\u76ae\u8102\u7ec6\u80de\u7684\u8102\u80aa\u9178\u4ece\u5934\u5408\u6210\uff08DNL\uff09\uff0c\u76f4\u63a5\u6291\u5236\u9762\u90e8\u76ae\u8102\u751f\u6210\uff1b\u548c\uff082\uff09\u901a\u8fc7\u51cf\u5c11\u7ec6\u80de\u56e0\u5b50\u5206\u6ccc\u548cTh17\u5206\u5316\u6765\u6291\u5236\u708e\u75c7\u3002\u6b4c\u793c\u5df2\u4eceSagimet Biosciences Inc.\u83b7\u5f97ASC40\u5728\u5927\u4e2d\u534e\u533a\u7684\u5f00\u53d1\u3001\u751f\u4ea7\u548c\u5546\u4e1a\u5316\u72ec\u5bb6\u6743\u76ca\u3002<\/p>\n \u75e4\u75ae\u662f\u5168\u7403\u7b2c\u516b\u5927\u5e38\u89c1\u75be\u75c5\uff0c\u5f71\u54cd\u5168\u7403\u8d85\u8fc76.4\u4ebf\u4eba[1]<\/sup>\u3002\u4e0e\u53e3\u670d\u836f\u7269\u76f8\u6bd4\uff0c\u5916\u7528\u7597\u6cd5\u7684\u4f9d\u4ece\u6027\u66f4\u4f4e\uff1a\u636e\u4f30\u8ba1\uff0c\u7ea6\u670930%\u81f340%\u7684\u60a3\u8005\u65e0\u6cd5\u575a\u6301\u5916\u7528\u6cbb\u7597[2]<\/sup>\u3002\u76ee\u524d\uff0c\u6709\u6548\u7684\u53e3\u670d\u75e4\u75ae\u836f\u7269\u4e3b\u8981\u662f\u5f02\u7ef4A\u9178\uff0c\u5176\u53ef\u80fd\u4f1a\u5bfc\u81f4\u8bb8\u591a\u4e25\u91cd\u7684\u4e0d\u826f\u4e8b\u4ef6\uff0c\u5982\u809d\u6bd2\u6027\u3001\u542c\u529b\u969c\u788d\u548c\u6291\u90c1\u75c7\u7b49\u3002ASC40\u6709\u671b\u6210\u4e3a\u540c\u7c7b\u9996\u521b\u3001\u6bcf\u65e5\u4e00\u6b21\u3001\u60a3\u8005\u4f9d\u4ece\u6027\u9ad8\u7684\u53e3\u670d\u75e4\u75ae\u836f\u7269\u3002<\/p>\n "\u75e4\u75ae\u6cbb\u7597\u7f3a\u4e4f\u65b0\u836f\u4e0a\u5e02\uff0cASC40\u662f\u5177\u6709\u5168\u65b0\u4f5c\u7528\u673a\u5236\u7684\u53e3\u670d\u75e4\u75ae\u5019\u9009\u836f\u7269\u3002"\u590d\u65e6\u5927\u5b66\u9644\u5c5e\u534e\u5c71\u533b\u9662\u76ae\u80a4\u79d1\u4e3b\u4efb\u533b\u5e08\uff0c\u590d\u65e6\u5927\u5b66\u76ae\u80a4\u75c5\u5b66\u7814\u7a76\u6240\u5e38\u52a1\u526f\u6240\u957f\uff0c\u4e2d\u56fd\u533b\u5e08\u534f\u4f1a\u76ae\u80a4\u79d1\u533b\u5e08\u5206\u4f1a\u526f\u4f1a\u957f\uff0cASC40\u4e2d\u3001\u91cd\u5ea6\u75e4\u75aeIII\u671f\u4e34\u5e8a\u8bd5\u9a8c\u4e3b\u8981\u7814\u7a76\u8005\u9879\u857e\u7ea2\u6559\u6388\u8868\u793a\u3002<\/p>\n "\u5f88\u9ad8\u5174\u6b4c\u793c\u53d6\u5f97\u4e86\u53c8\u4e00\u4e2a\u91cc\u7a0b\u7891\uff0c\u5f70\u663e\u4e86\u6211\u4eec\u628a\u7ba1\u7ebf\u9879\u76ee\u5feb\u901f\u63a8\u8fdb\u5230\u4e34\u5e8a\u540e\u671f\u7684\u5353\u8d8a\u6267\u884c\u529b\u3002\u4f5c\u4e3a\u540c\u7c7b\u9996\u521b\u3001\u62e5\u6709\u6cbb\u7597\u75e4\u75ae\u65b0\u578b\u4f5c\u7528\u673a\u5236\u7684\u5019\u9009\u836f\u7269\uff0cASC40\u5728II\u671f\u7814\u7a76\u4e2d\u8868\u73b0\u51fa\u4e86\u663e\u8457\u7684\u7597\u6548\u548c\u826f\u597d\u7684\u5b89\u5168\u6027\u3002\u6211\u4eec\u76f8\u4fe1\uff0c\u5168\u65b0\u7684\u4f5c\u7528\u673a\u5236\u5c06\u6709\u52a9\u4e8eASC40\u6210\u4e3a\u6cbb\u7597\u4e2d\u3001\u91cd\u5ea6\u75e4\u75ae\u5b89\u5168\u4e14\u6709\u6548\u7684\u65b9\u6848\u3002"\u6b4c\u793c\u521b\u59cb\u4eba\u3001\u8463\u4e8b\u4f1a\u4e3b\u5e2d\u517c\u9996\u5e2d\u6267\u884c\u5b98\u5434\u52b2\u6893\u535a\u58eb\u8868\u793a\u3002<\/p>\n[1]Tan J K, Bhate K. A global perspective on the epidemiology of acne [J]. Br J Dermatol 2015, 172 Suppl 1(3-12). DOI: 10.1111\/bjd.13462.<\/p>\n[2]Purvis CG, Balogh EA, Feldman SR. Clascoterone: How the Novel Androgen Receptor Inhibitor Fits Into the Acne Treatment Paradigm. Ann Pharmacother. 2021;55(10):1297-1299. doi:10.1177\/1060028021992055.<\/p>\n \u5173\u4e8e\u6b4c\u793c<\/b><\/p>\n \u6b4c\u793c\u662f\u4e00\u5bb6\u5728\u9999\u6e2f\u8bc1\u5238\u4ea4\u6613\u6240\u4e0a\u5e02\uff081672.HK\uff09\u7684\u521b\u65b0\u7814\u53d1\u9a71\u52a8\u578b\u751f\u7269\u79d1\u6280\u516c\u53f8\uff0c\u6db5\u76d6\u4e86\u4ece\u65b0\u836f\u7814\u53d1\u81f3\u751f\u4ea7\u548c\u5546\u4e1a\u5316\u7684\u5b8c\u6574\u4ef7\u503c\u94fe\u3002\u6b4c\u793c\u7684\u7ba1\u7406\u56e2\u961f\u5177\u5907\u6df1\u539a\u7684\u4e13\u4e1a\u77e5\u8bc6\u53ca\u4f18\u79c0\u7684\u8fc7\u5f80\u6210\u5c31\uff0c\u5728\u56e2\u961f\u7684\u5e26\u9886\u4e0b\uff0c\u6b4c\u793c\u805a\u7126\u4e09\u5927\u4e34\u5e8a\u9700\u6c42\u5c1a\u672a\u6ee1\u8db3\u7684\u533b\u7597\u9886\u57df\uff1a\u75c5\u6bd2\u6027\u75be\u75c5\u3001\u975e\u9152\u7cbe\u6027\u8102\u80aa\u6027\u809d\u708e\u548c\u80bf\u7624\uff0c\u5e76\u4ee5\u5168\u7403\u5316\u7684\u89c6\u91ce\u8fdb\u884c\u5e03\u5c40\u3002\u51ed\u501f\u5353\u8d8a\u7684\u6267\u884c\u529b\uff0c\u6b4c\u793c\u5feb\u901f\u63a8\u8fdb\u836f\u7269\u7ba1\u7ebf\u5f00\u53d1\uff0c\u4e89\u53d6\u5728\u56fd\u9645\u7ade\u4e89\u4e2d\u5360\u636e\u9886\u5148\u5730\u4f4d\u3002\u6b4c\u793c\u76ee\u524d\u62e5\u6709\u591a\u6b3e\u5728\u7814\u836f\u7269, \u6700\u524d\u6cbf\u7684\u5019\u9009\u836f\u7269\u5305\u62ecASC22\uff08\u4e59\u809d\u529f\u80fd\u6027\u6cbb\u6108\uff09\u3001ASC40\uff08\u75e4\u75ae\uff09\u3001ASC40\uff08\u590d\u53d1\u6027\u80f6\u8d28\u6bcd\u7ec6\u80de\u7624\uff09\u3001ASC40(\u975e\u9152\u7cbe\u6027\u8102\u80aa\u6027\u809d\u708e)\u3001ASC41(\u975e\u9152\u7cbe\u6027\u8102\u80aa\u6027\u809d\u708e)\u53caASC61\uff08\u665a\u671f\u5b9e\u4f53\u7624\uff09\u3002<\/p>\n \u6b32\u4e86\u89e3\u66f4\u591a\u4fe1\u606f\uff0c\u656c\u8bf7\u767b\u5f55\u7f51\u7ad9\uff1awww.ascletis.com<\/a>\u3002<\/p>\n","protected":false},"excerpt":{"rendered":" –ASC40\u6cbb\u7597\u4e2d\u3001\u91cd\u5ea6\u5bfb\u5e38\u6027\u75e4\u75ae\u7684\u2162\u671f\u4e34\u5e8a\u8bd5\u9a8c\u5c06\u5165\u7ec4480\u4f8b\u53d7\u8bd5\u8005 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A global perspective on the epidemiology of acne [J]. Br J Dermatol 2015, 172 Suppl 1(3-12). DOI: 10.1111\/bjd.13462. [2]Purvis CG, Balogh EA, Feldman SR. 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