{"id":100077,"date":"2023-12-04T07:49:00","date_gmt":"2023-12-04T00:49:00","guid":{"rendered":"https:\/\/www.xinwengao.com\/cn\/pr\/20231204074900100077"},"modified":"2023-12-04T22:10:38","modified_gmt":"2023-12-04T14:10:38","slug":"%e4%ba%91%e9%a1%b6%e6%96%b0%e8%80%80%e5%ae%a3%e5%b8%83%e4%b8%ad%e5%9b%bd%e5%9b%bd%e5%ae%b6%e8%8d%af%e5%93%81%e7%9b%91%e7%9d%a3%e7%ae%a1%e7%90%86%e5%b1%80%e5%8f%97%e7%90%86zetomipzomib%ef%bc%88","status":"publish","type":"post","link":"https:\/\/www.xinwengao.com\/cn\/pr\/20231204074900100077","title":{"rendered":"\u4e91\u9876\u65b0\u8000\u5ba3\u5e03\u4e2d\u56fd\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u53d7\u7406Zetomipzomib\uff08\u6cfd\u6258\u4f50\u7c73\uff09\u7684\u65b0\u836f\u4e34\u5e8a\u8bd5\u9a8c\u7533\u8bf7"},"content":{"rendered":"

— <\/i>\u4e91\u9876\u65b0\u8000\u8ba1\u5212\u4e0e\u5408\u4f5c\u4f19\u4f34<\/i>Kezar<\/i>\u5171\u540c\u63a8\u8fdb\u6b63\u5728\u5f00\u5c55\u7684<\/i>zetomipzomib<\/i>\uff08\u6cfd\u6258\u4f50\u7c73\uff09\u6cbb\u7597\u6d3b\u52a8\u6027\u72fc\u75ae\u6027\u80be\u708e\u7684\u5168\u7403<\/i>2b<\/span><\/i>\u671f<\/i>PALIZADE<\/i>\u7814\u7a76<\/i> \u2013 <\/i><\/p>\n

— Zetomipzomib<\/i>\uff08\u6cfd\u6258\u4f50\u7c73\uff09\u5728\u65e9\u524d\u7684<\/i>2<\/i>\u671f\u7814\u7a76\u4e2d\u83b7\u5f97\u79ef\u6781\u7ed3\u679c\uff0c\u7b2c<\/i>25<\/i>\u5468\uff08\u6cbb\u7597\u7ed3\u675f\uff09\u548c\u7b2c<\/i>37<\/i>\u5468\uff08\u5373\u505c\u836f\u968f\u8bbf\u7b2c<\/i>12<\/i>\u5468\uff09\u65f6\uff0c\u5177\u6709\u4e34\u5e8a\u610f\u4e49\u7684\u603b\u4f53\u80be\u810f\u7f13\u89e3\u7387\uff08<\/i>ORR<\/i>\uff09\u5206\u522b\u4e3a<\/i>64.7%<\/i>\u548c<\/i>88.2%<\/i>\uff0c\u5b8c\u5168\u80be\u810f\u7f13\u89e3\u7387\uff08<\/i>CRR<\/i>\uff09\u5206\u522b\u4e3a<\/i>35.3%<\/i>\u548c<\/i>41.2%<\/i>\uff0c\u5c3f\u86cb\u767d\u808c\u9150\u6bd4\u503c\uff08<\/i>UPCR<\/i>\uff09\u5206\u522b\u8f83\u57fa\u7ebf\u5e73\u5747\u4e0b\u964d<\/i>57.0%<\/i>\u548c<\/i>83.0%<\/i>\uff0c\u540c\u65f6\u80be\u5c0f\u7403\u6ee4\u8fc7\u7387\u4f30\u8ba1\u503c\uff08<\/i>eGFR<\/i>\uff09\u5728\u6cbb\u7597\u671f\u95f4\u4fdd\u6301\u7a33\u5b9a<\/i> \u2013<\/i> <\/p>\n

—<\/i>\u80be\u75c5\u548c\u81ea\u8eab\u514d\u75ab\u6027\u75be\u75c5\u662f\u4e91\u9876\u65b0\u8000\u7684\u91cd\u70b9\u5173\u6ce8\u9886\u57df\uff0c<\/i>zetomipzomib<\/i>\uff08\u6cfd\u6258\u4f50\u7c73\uff09\u53ef\u5f00\u53d1\u7528\u4e8e\u6cbb\u7597\u5305\u62ec\u72fc\u75ae\u6027\u80be\u708e\u3001\u7cfb\u7edf\u6027\u7ea2\u6591\u72fc\u75ae\u5728\u5185\u7684\u4e00\u7cfb\u5217\u81ea\u8eab\u514d\u75ab\u6027\u75be\u75c5\uff0c\u6709\u671b\u8fdb\u4e00\u6b65\u52a0\u5f3a\u516c\u53f8\u5728\u81ea\u514d\u75be\u75c5\u9886\u57df\u7684\u9886\u5148\u5730\u4f4d<\/i>\u2014<\/i><\/p>\n

\u4e0a\u6d77<\/span>2023\u5e7412\u67084\u65e5<\/span> \/\u7f8e\u901a\u793e\/ — \u4e91\u9876\u65b0\u8000\uff08HKEX 1952.HK\uff09\u662f\u4e00\u5bb6\u4e13\u6ce8\u4e8e\u521b\u65b0\u836f\u548c\u75ab\u82d7\u5f00\u53d1\u3001\u5236\u9020\u3001\u5546\u4e1a\u5316\u7684\u751f\u7269\u5236\u836f\u516c\u53f8\uff0c\u4eca\u65e5\u5ba3\u5e03\u4e2d\u56fd\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08NMPA\uff09\u5df2\u53d7\u7406zetomipzomib\uff08\u6cfd\u6258\u4f50\u7c73\uff09\u5728\u4e2d\u56fd\u7684\u65b0\u836f\u4e34\u5e8a\u8bd5\u9a8c\uff08IND\uff09\u7533\u8bf7\u3002Zetomipzomib\u662f\u4e00\u6b3e\u65b0\u4e00\u7c7b\u9996\u521b\u3001\u9009\u62e9\u6027\u514d\u75ab\u86cb\u767d\u9176\u4f53\u6291\u5236\u5242\uff0c\u7528\u4e8e\u6cbb\u7597\u5305\u62ec\u72fc\u75ae\u6027\u80be\u708e\u3001\u7cfb\u7edf\u6027\u7ea2\u6591\u72fc\u75ae\u5728\u5185\u7684\u4e00\u7cfb\u5217\u81ea\u8eab\u514d\u75ab\u6027\u75be\u75c5\u3002<\/p>\n

\u8bb8\u591a\u81ea\u8eab\u514d\u75ab\u6027\u75be\u75c5\uff0c\u5305\u62ec\u72fc\u75ae\u6027\u80be\u708e\u548c\u7cfb\u7edf\u6027\u7ea2\u6591\u72fc\u75ae\uff0c\u5728\u4e9a\u6d32\u7684\u53d1\u75c5\u7387\u76f8\u6bd4\u5176\u4ed6\u5730\u533a\u66f4\u9ad8\u3002\u636e\u4f30\u8ba1\uff0c\u4ec5\u5728\u4e2d\u56fd\u5c31\u6709100\u4e07\u7cfb\u7edf\u6027\u7ea2\u6591\u72fc\u75ae\u60a3\u8005\uff0c40%~60% \u7cfb\u7edf\u6027\u7ea2\u6591\u72fc\u75ae\u60a3\u8005\u7684\u75be\u75c5\u7d2f\u53ca\u80be\u810f\uff0c\u5373\u72fc\u75ae\u6027\u80be\u708e\u3002\u72fc\u75ae\u6027\u80be\u708e\u662f\u6700\u5e38\u89c1\u7684\u7ee7\u53d1\u6027\u514d\u75ab\u6027\u80be\u5c0f\u7403\u75be\u75c5\uff0c\u968f\u7740\u75be\u75c5\u53d1\u5c55\u53ef\u9010\u6e10\u5bfc\u81f4\u80be\u529f\u80fd\u8870\u7aed\uff0c\u662f\u7ec8\u672b\u671f\u80be\u75c5\u7684\u5e38\u89c1\u75c5\u56e0\u4e4b\u4e00\u3002\u533a\u522b\u4e8e\u4f20\u7edf\u7684\u76f4\u63a5\u514d\u75ab\u6291\u5236\u5242\u4f5c\u7528\uff0czetomipzomib\uff08\u6cfd\u6258\u4f50\u7c73\uff09\u53ef\u4ee5\u8c03\u8282\u5148\u5929\u514d\u75ab\u548c\u83b7\u5f97\u6027\u514d\u75ab\u53cd\u5e94\uff0c\u4ece\u800c\u964d\u4f4e\u708e\u75c7\u5bf9\u5668\u5b98\u9020\u6210\u7684\u635f\u4f24\uff0c\u8fd9\u4e00\u7279\u6027\u4f7f\u5176\u5177\u6709\u6cbb\u7597\u591a\u79cd\u81ea\u8eab\u514d\u75ab\u6027\u75be\u75c5\u7684\u6f5c\u529b\uff0c\u4e14zetomipzomib\uff08\u6cfd\u6258\u4f50\u7c73\uff09\u5bf9\u514d\u75ab\u86cb\u767d\u9176\u4f53\u7684\u9009\u62e9\u6027\u6291\u5236\u53c8\u53ef\u907f\u514d\u53cc\u91cd\u9776\u5411\u86cb\u767d\u9176\u4f53\u6291\u5236\u76f8\u5173\u7684\u5168\u8eab\u526f\u4f5c\u7528\u3002<\/p>\n

\u4e91\u9876\u65b0\u8000\u8ba1\u5212\u4e0e\u5408\u4f5c\u4f19\u4f34Kezar Life Sciences\u5171\u540c\u63a8\u8fdbPALIZADE\u7814\u7a76\uff0c\u8fd9\u662f\u4e00\u9879\u5168\u7403\u6027\u3001\u5b89\u6170\u5242\u5bf9\u71672b\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u65e8\u5728\u8bc4\u4f30\u4e24\u79cd\u5242\u91cf\u6c34\u5e73\u7684zetomipzomib\uff08\u6cfd\u6258\u4f50\u7c73\uff09\u5728\u6d3b\u52a8\u6027\u72fc\u75ae\u6027\u80be\u708e\u60a3\u8005\u4e2d\u7684\u7597\u6548\u548c\u5b89\u5168\u6027\u3002<\/p>\n

\u4e91\u9876\u65b0\u8000\u9996\u5e2d\u6267\u884c\u5b98\u7f57\u6c38\u5e86\u8868\u793a\uff1a"Zetomipzomib\uff08\u6cfd\u6258\u4f50\u7c73\uff09\u7684IND\u7533\u8bf7\u987a\u5229\u53d7\u7406\u6807\u5fd7\u7740\u6211\u4eec\u671d\u7740\u5728\u4e2d\u56fd\u5f00\u5c55\u8be5\u5019\u9009\u836f\u7269\u7684\u4e34\u5e8a\u7814\u7a76\u8fc8\u51fa\u4e86\u91cd\u8981\u4e00\u6b65\uff0c\u6211\u4eec\u671f\u5f85\u5728\u72fc\u75ae\u6027\u80be\u708e\u9ad8\u53d1\u7684\u4e2d\u56fd\u5165\u7ec4\u60a3\u8005\uff0c\u6210\u4e3aPALIZADE\u5168\u7403\u7814\u7a76\u7684\u91cd\u8981\u7ec4\u6210\u90e8\u5206\uff0c\u5e76\u5229\u7528\u516c\u53f8\u5728\u4e34\u5e8a\u5f00\u53d1\u548c\u6ce8\u518c\u4e0a\u5e02\u7b49\u65b9\u9762\u7684\u4e30\u5bcc\u7ecf\u9a8c\uff0c\u5c3d\u5feb\u5c06\u8fd9\u4e00\u91cd\u8981\u7684\u521b\u65b0\u7597\u6cd5\u5e26\u7ed9\u4e9a\u6d32\u60a3\u8005\u3002\u80be\u75c5\u548c\u81ea\u8eab\u514d\u75ab\u6027\u75be\u75c5\u662f\u516c\u53f8\u7684\u91cd\u70b9\u6cbb\u7597\u9886\u57df\uff0c\u51ed\u501fzetomipzomib\uff08\u6cfd\u6258\u4f50\u7c73\uff09\u5728\u72fc\u75ae\u6027\u80be\u708e\u548c\u5176\u4ed6\u81ea\u514d\u6027\u75be\u75c5\u9886\u57df\u7684\u6f5c\u529b\uff0c\u5c06\u8fdb\u4e00\u6b65\u5de9\u56fa\u4e91\u9876\u65b0\u8000\u5728\u4e9a\u6d32\u7684\u9886\u5148\u5730\u4f4d\u3002"<\/p>\n

Zetomipzomib\uff08\u6cfd\u6258\u4f50\u7c73\uff09\u5728\u65e9\u524d\u76842\u671f\u4e34\u5e8a\u7814\u7a76\u4e2d\u83b7\u5f97\u79ef\u6781\u7ed3\u679c\uff0c\u7b2c25\u5468\uff08\u6cbb\u7597\u7ed3\u675f\uff09\u548c\u7b2c37\u5468\uff08\u5373\u505c\u836f\u968f\u8bbf\u7b2c12\u5468\uff09\u65f6\uff0c\u5177\u6709\u4e34\u5e8a\u610f\u4e49\u7684\u603b\u4f53\u80be\u810f\u7f13\u89e3\u7387\uff08ORR\uff09\u5206\u522b\u4e3a64.7%\u548c88.2%\uff0c\u5b8c\u5168\u80be\u810f\u7f13\u89e3\u7387\uff08CRR\uff09\u5206\u522b\u4e3a35.3%\u548c41.2%\uff0c\u5c3f\u86cb\u767d\u808c\u9150\u6bd4\u503c\uff08UPCR\uff09\u5206\u522b\u8f83\u57fa\u7ebf\u5e73\u5747\u4e0b\u964d57.0%\u548c83.0%\uff0c\u540c\u65f6\u80be\u5c0f\u7403\u6ee4\u8fc7\u7387\u4f30\u8ba1\u503c\uff08eGFR\uff09\u5728\u6cbb\u7597\u671f\u95f4\u4fdd\u6301\u7a33\u5b9a\u3002\u7814\u7a76\u671f\u95f4\uff0czetomipzomib\uff08\u6cfd\u6258\u4f50\u7c73\uff09\u8fd8\u8868\u73b0\u51fa\u826f\u597d\u7684\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\uff0c\u4e14\u968f\u8bbf\u671f\u5185\u672a\u53d1\u73b0\u65b0\u7684\u5b89\u5168\u6027\u4fe1\u53f7\u3002<\/p>\n

\u5173\u4e8e<\/b>Zetomipzomib <\/b>\uff08\u6cfd\u6258\u4f50\u7c73\uff09<\/b><\/p>\n

Zetomipzomib\uff08\u6cfd\u6258\u4f50\u7c73\uff0cKZR-616\uff09\u662f\u4e00\u6b3e\u65b0\u578b\u3001\u540c\u7c7b\u9996\u521b\u3001\u9009\u62e9\u6027\u514d\u75ab\u86cb\u767d\u9176\u4f53\u6291\u5236\u5242\uff0c\u5728\u591a\u79cd\u81ea\u8eab\u514d\u75ab\u6027\u75be\u75c5\u4e2d\u5177\u6709\u5e7f\u6cdb\u7684\u6cbb\u7597\u6f5c\u529b\u3002\u4e34\u5e8a\u524d\u7814\u7a76\u8868\u660e\uff0c\u9009\u62e9\u6027\u514d\u75ab\u86cb\u767d\u9176\u4f53\u6291\u5236\u5728\u591a\u79cd\u81ea\u8eab\u514d\u75ab\u6027\u75be\u75c5\u7684\u52a8\u7269\u6a21\u578b\u4e2d\u4ea7\u751f\u5e7f\u6cdb\u7684\u6297\u708e\u53cd\u5e94\uff0c\u540c\u65f6\u907f\u514d\u514d\u75ab\u6291\u5236\u4f5c\u7528\u30021\u671f\u548c2\u671f\u4e34\u5e8a\u8bd5\u9a8c\u7684\u6570\u636e\u5145\u5206\u8868\u660ezetomipzomib\uff08\u6cfd\u6258\u4f50\u7c73\uff09\u5728\u6cbb\u7597\u4e25\u91cd\u3001\u6162\u6027\u81ea\u8eab\u514d\u75ab\u6027\u75be\u75c5\u65b9\u9762\u5177\u6709\u826f\u597d\u7684\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\u7279\u5f81\u3002<\/p>\n

\u5173\u4e8e<\/b>PALIZADE<\/b>\u7814\u7a76<\/b><\/p>\n

PALIZADE\u662f\u4e00\u9879\u5168\u7403\u6027\u3001\u5b89\u6170\u5242\u5bf9\u7167\u3001\u968f\u673a\u3001\u53cc\u76f22b\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u65e8\u5728\u8bc4\u4f30\u4e24\u79cd\u5242\u91cf\u6c34\u5e73\u7684zetomipzomib\uff08\u6cfd\u6258\u4f50\u7c73\uff09\u5728\u6d3b\u52a8\u6027\u72fc\u75ae\u6027\u80be\u708e\u60a3\u8005\u4e2d\u7684\u7597\u6548\u548c\u5b89\u5168\u6027\u3002\u76ee\u6807\u5165\u7ec4\u4eba\u6570\u4e3a279\u540d\u60a3\u8005\uff0c\u8fd9\u4e9b\u60a3\u8005\u5728\u6807\u51c6\u80cc\u666f\u6cbb\u7597\u7684\u57fa\u7840\u4e0a\u88ab\u968f\u673a\u5206\u914d\u63a5\u53d730 mg zetomipzomib\u300160 mg zetomipzomib\u6216\u5b89\u6170\u5242\uff0c\u76ae\u4e0b\u7ed9\u836f\uff0c\u6bcf\u54681\u6b21\uff0c\u6301\u7eed52\u5468\u3002\u80cc\u666f\u6cbb\u7597\u53ef\u5305\u62ec\u6807\u51c6\u8bf1\u5bfc\u6cbb\u7597\uff08\u975e\u5f3a\u5236\u8981\u6c42\uff09\u3002\u5728\u6700\u521d\u768416\u5468\u5185\uff0c\u5c06\u5f3a\u5236\u5c06\u76ae\u8d28\u7c7b\u56fa\u9187\u9010\u6e10\u51cf\u91cf\u81f35 mg\/d\u6216\u66f4\u5c11\u3002\u6cbb\u7597\u7ed3\u675f\u8bc4\u4f30\u5c06\u5728\u7b2c53\u5468\u8fdb\u884c\u3002\u4e3b\u8981\u7597\u6548\u7ec8\u70b9\u662f\u7b2c37\u5468\u65f6\u8fbe\u5230\u5b8c\u5168\u80be\u810f\u7f13\u89e3\uff08CRR\uff09\u7684\u60a3\u8005\u6bd4\u4f8b\uff0c\u5b8c\u5168\u80be\u810f\u7f13\u89e3\u5305\u62ec\u5728\u672a\u63a5\u53d7\u633d\u6551\u6216\u7981\u7528\u836f\u7269\u7684\u60c5\u51b5\u4e0b\uff0c\u5c3f\u86cb\u767d\u808c\u9150\u6bd4\u503c\uff08UPCR\uff09\u5c0f\u4e8e\u6216\u7b49\u4e8e0.5\u3002\u6709\u5173PALIZADE\u7684\u66f4\u591a\u4fe1\u606f\uff0c\u8bf7\u53c2\u89c1NCT05781750<\/a>\u3002<\/p>\n

\u5173\u4e8e\u4e91\u9876\u65b0\u8000<\/b><\/p>\n

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— \u4e91\u9876\u65b0\u8000\u8ba1\u5212\u4e0e\u5408\u4f5c\u4f19\u4f34Kezar\u5171\u540c\u63a8\u8fdb\u6b63\u5728\u5f00\u5c55\u7684zetomipzomib\uff08\u6cfd\u6258\u4f50\u7c73\uff09\u6cbb\u7597\u6d3b\u52a8\u6027\u72fc\u75ae\u6027\u80be\u708e\u7684\u5168\u74032b\u671fPALIZADE\u7814\u7a76 \u2013 — 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—\u80be\u75c5\u548c\u81ea\u8eab\u514d\u75ab\u6027\u75be\u75c5\u662f\u4e91\u9876\u65b0\u8000\u7684\u91cd\u70b9\u5173\u6ce8\u9886\u57df\uff0czetomipzomib\uff08\u6cfd\u6258\u4f50\u7c73\uff09\u53ef\u5f00\u53d1\u7528\u4e8e\u6cbb\u7597\u5305\u62ec\u72fc\u75ae\u6027\u80be\u708e\u3001\u7cfb\u7edf\u6027\u7ea2\u6591\u72fc\u75ae\u5728\u5185\u7684\u4e00\u7cfb\u5217\u81ea\u8eab\u514d\u75ab\u6027\u75be\u75c5\uff0c\u6709\u671b\u8fdb\u4e00\u6b65\u52a0\u5f3a\u516c\u53f8\u5728\u81ea\u514d\u75be\u75c5\u9886\u57df\u7684\u9886\u5148\u5730\u4f4d\u2014 \u4e0a\u6d772023\u5e7412\u67084\u65e5 \/\u7f8e\u901a\u793e\/ — \u4e91\u9876\u65b0\u8000\uff08HKEX 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